Genomes and Genes
Experts and Doctors on caenorhabditis elegans proteins in United States
Locale: United States
Topic: caenorhabditis elegans proteins
Publications397 found, 100 shown here
- Li X, Johnson R, Park D, Chin Sang I, Chamberlin H. Somatic gonad sheath cells and Eph receptor signaling promote germ-cell death in C. elegans. Cell Death Differ. 2012;19:1080-9 pubmed publisher..This work defines a non-autonomous, pro-apoptotic signaling for efficient physiological cell death, and highlights the dynamic nature of intercellular communication between dying cells and the phagocytes that remove them...
- Juang B, Gu C, Starnes L, Palladino F, Goga A, Kennedy S, et al. Endogenous nuclear RNAi mediates behavioral adaptation to odor. Cell. 2013;154:1010-1022 pubmed publisher..This class of siRNA may act broadly as a rheostat allowing prolonged stimulation to dampen gene expression and promote cellular memory formation. PAPERFLICK: ..
- Yuan Y, Hakimi P, Kao C, Kao A, Liu R, Janocha A, et al. Reciprocal Changes in Phosphoenolpyruvate Carboxykinase and Pyruvate Kinase with Age Are a Determinant of Aging in Caenorhabditis elegans. J Biol Chem. 2016;291:1307-19 pubmed publisher..Thus, a programmed metabolic event involving PEPCK-C and PK is a determinant of aging that can be modified to modulate aging. ..
- Davis M, Montalbano A, Wood M, Schisa J. Biphasic adaptation to osmotic stress in the C. elegans germ line. Am J Physiol Cell Physiol. 2017;312:C741-C748 pubmed publisher..We speculate that increased glycerol levels may function as a secondary osmoregulatory adaptive response in the germ line, following a primary response of RNP granule assembly. ..
- Kawasaki I, Shim Y, Kirchner J, Kaminker J, Wood W, Strome S. PGL-1, a predicted RNA-binding component of germ granules, is essential for fertility in C. elegans. Cell. 1998;94:635-45 pubmed..Elimination of PGL-1 results in defective germ granules and sterility. Interestingly, PGL-1 function is required for fertility only at elevated temperatures, suggesting that germline development is inherently sensitive to temperature. ..
- Bachorik J, Kimble J. Redundant control of the Caenorhabditis elegans sperm/oocyte switch by PUF-8 and FBF-1, two distinct PUF RNA-binding proteins. Proc Natl Acad Sci U S A. 2005;102:10893-7 pubmed..We suggest that PUF-8 and FBF-1 may control fog-2 expression, and that the sperm/oocyte decision occurs in the distal germ line. ..
- Fei Y, Romero M, Krause M, Liu J, Huang W, Ganapathy V, et al. A novel H(+)-coupled oligopeptide transporter (OPT3) from Caenorhabditis elegans with a predominant function as a H(+) channel and an exclusive expression in neurons. J Biol Chem. 2000;275:9563-71 pubmed..elegans demonstrate that opt3 gene is exclusively expressed in neurons. OPT3 may play an important physiological role as a pH balancer in the maintenance of H(+) homeostasis in C. elegans. ..
- Barr M, DeModena J, Braun D, Nguyen C, Hall D, Sternberg P. The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway. Curr Biol. 2001;11:1341-6 pubmed
- Kayser E, Sedensky M, Morgan P. The effects of complex I function and oxidative damage on lifespan and anesthetic sensitivity in Caenorhabditis elegans. Mech Ageing Dev. 2004;125:455-64 pubmed..In contrast, the effects of mitochondrial changes on anesthetic sensitivity appear to be mediated by both altered respiration and oxidative damage. ..
- Yu H, Seah A, Herman M, Ferguson E, Horvitz H, Sternberg P. Wnt and EGF pathways act together to induce C. elegans male hook development. Dev Biol. 2009;327:419-32 pubmed publisher..lin-17 and bar-1/beta-catenin are preferentially expressed in the presumptive 1 degree cell P11.p. The dynamic subcellular localization of BAR-1-GFP in P11.p is concordant with the timing of HCG fate determination. ..
- Lee M, Kim K, Morgan C, Morgan D, Kimble J. Phosphorylation state of a Tob/BTG protein, FOG-3, regulates initiation and maintenance of the Caenorhabditis elegans sperm fate program. Proc Natl Acad Sci U S A. 2011;108:9125-30 pubmed publisher..We discuss implications of our results for Tob/BTG proteins in vertebrates. ..
- Nehrke K. A reduction in intestinal cell pHi due to loss of the Caenorhabditis elegans Na+/H+ exchanger NHX-2 increases life span. J Biol Chem. 2003;278:44657-66 pubmed..Our data demonstrate a functional role for a Na+/H+ exchanger in nutrient absorption in vivo and lays the groundwork for examining integrated acid-base physiology in a non-mammalian model organism...
- Lee M, Hook B, Lamont L, Wickens M, Kimble J. LIP-1 phosphatase controls the extent of germline proliferation in Caenorhabditis elegans. EMBO J. 2006;25:88-96 pubmed..The control of germline proliferation by LIP-1 has intriguing parallels with the control of stem cells and progenitor cells in vertebrates. ..
- Lockwood C, Zaidel Bar R, Hardin J. The C. elegans zonula occludens ortholog cooperates with the cadherin complex to recruit actin during morphogenesis. Curr Biol. 2008;18:1333-7 pubmed publisher..These results show that ZOO-1 cooperates with the cadherin-catenin complex to dynamically regulate strong junctional anchorage to the actin cytoskeleton during morphogenesis. ..
- Luo S, Shaw W, Ashraf J, Murphy C. TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging. PLoS Genet. 2009;5:e1000789 pubmed publisher..Our results suggest that longevity and reproductive span regulation can be uncoupled, although they appear to normally be linked through regulatory pathways. ..
- Gilder A, Chen Y, Jackson R, Jiang J, Maher J. Fem1b promotes ubiquitylation and suppresses transcriptional activity of Gli1. Biochem Biophys Res Commun. 2013;440:431-6 pubmed publisher..These findings have implications for understanding the cellular functions of Fem1b, and the regulation of Gli1 oncoprotein activity. ..
- Lin R, Thompson S, Priess J. pop-1 encodes an HMG box protein required for the specification of a mesoderm precursor in early C. elegans embryos. Cell. 1995;83:599-609 pubmed..We propose that POP-1 and SKN-1 function together in the early embryo to allow MS-specific differentiation. ..
- Xu L, Strome S. Depletion of a novel SET-domain protein enhances the sterility of mes-3 and mes-4 mutants of Caenorhabditis elegans. Genetics. 2001;159:1019-29 pubmed..Our results suggest that SET-2 participates along with the MES proteins in promoting normal germline development...
- Fei Y, Inoue K, Ganapathy V. Structural and functional characteristics of two sodium-coupled dicarboxylate transporters (ceNaDC1 and ceNaDC2) from Caenorhabditis elegans and their relevance to life span. J Biol Chem. 2003;278:6136-44 pubmed..elegans may lead to decreased availability of dicarboxylates for cellular production of metabolic energy, thus creating a biological state similar to that of caloric restriction, and consequently leading to life span extension. ..
- Palmer R, Inoue T, Sherwood D, Jiang L, Sternberg P. Caenorhabditis elegans cog-1 locus encodes GTX/Nkx6.1 homeodomain proteins and regulates multiple aspects of reproductive system development. Dev Biol. 2002;252:202-13 pubmed..Two mutant alleles of cog-1 differentially affect alternative transcripts and cause different phenotypes, suggesting that the two forms of cog-1 have distinct functions in C. elegans. ..
- Yan N, Xu Y, Shi Y. 2:1 Stoichiometry of the CED-4-CED-9 complex and the tetrameric CED-4: insights into the regulation of CED-3 activation. Cell Cycle. 2006;5:31-4 pubmed..On the basis of structural and biochemical analyses, working models are proposed to explain the mechanism by which CED-4 facilitates CED-3 activation. ..
- Wu M, Herman M. A novel noncanonical Wnt pathway is involved in the regulation of the asymmetric B cell division in C. elegans. Dev Biol. 2006;293:316-29 pubmed..We conclude that a noncanonical Wnt pathway, which is different from other Wnt pathways in C. elegans, regulates B cell polarity. ..
- Schroeder L, Kremer S, Kramer M, Currie E, Kwan E, Watts J, et al. Function of the Caenorhabditis elegans ABC transporter PGP-2 in the biogenesis of a lysosome-related fat storage organelle. Mol Biol Cell. 2007;18:995-1008 pubmed..Our results provide an explanation for the loss of Nile Red-stained fat in pgp-2(-) animals as well as insight into the specialized function of this lysosome-related organelle...
- Tong X, Buechner M. CRIP homologues maintain apical cytoskeleton to regulate tubule size in C. elegans. Dev Biol. 2008;317:225-33 pubmed publisher..EXC-9 and its nematode homologue act in polarized epithelial cells that must maintain great flexibility at their apical surface; our results suggest that CRIPs function to maintain cytoskeletal flexibility at the apical surface. ..
- Ezak M, Ferkey D. A functional nuclear localization sequence in the C. elegans TRPV channel OCR-2. PLoS ONE. 2011;6:e25047 pubmed publisher..These results suggest that the OCR-2 TRPV cation channel may have a direct nuclear function in neuronal cells that was not previously appreciated. ..
- Mcreynolds M, Wang W, Holleran L, Hanna Rose W. Uridine monophosphate synthetase enables eukaryotic de novo NAD+ biosynthesis from quinolinic acid. J Biol Chem. 2017;292:11147-11153 pubmed publisher..This mechanism for NAD+ biosynthesis creates novel possibilities for manipulating NAD+ biosynthetic pathways, which is key for the future of therapeutics. ..
- Choy R, Kemner J, Thomas J. Fluoxetine-resistance genes in Caenorhabditis elegans function in the intestine and may act in drug transport. Genetics. 2006;172:885-92 pubmed..One model that explains these findings is that NRF-5 binds fluoxetine and influences its presentation or availability to in vivo targets. ..
- Buckley B, Burkhart K, Gu S, Spracklin G, Kershner A, Fritz H, et al. A nuclear Argonaute promotes multigenerational epigenetic inheritance and germline immortality. Nature. 2012;489:447-51 pubmed publisher..We propose that C. elegans use the RNAi inheritance machinery to transmit epigenetic information, accrued by past generations, into future generations to regulate important biological processes. ..
- Hwang B, Sternberg P. A cell-specific enhancer that specifies lin-3 expression in the C. elegans anchor cell for vulval development. Development. 2004;131:143-51 pubmed
- Powers J, Rose D, Saunders A, Dunkelbarger S, Strome S, Saxton W. Loss of KLP-19 polar ejection force causes misorientation and missegregation of holocentric chromosomes. J Cell Biol. 2004;166:991-1001 pubmed
- Baldauf Z, Chomsung R, Carden W, May P, Bickford M. Ultrastructural analysis of projections to the pulvinar nucleus of the cat. I: Middle suprasylvian gyrus (areas 5 and 7). J Comp Neurol. 2005;485:87-107 pubmed..Interpretation of these results using Sherman and Guillery's recent theories of thalamic organization (Sherman and Guillery  Proc Natl Acad Sci U S A 95:7121-7126) suggests that area 7 may both drive and modulate PUL activity. ..
- Kim K, Wilson T, Kimble J. GLD-2/RNP-8 cytoplasmic poly(A) polymerase is a broad-spectrum regulator of the oogenesis program. Proc Natl Acad Sci U S A. 2010;107:17445-50 pubmed publisher..We propose that the GLD-2/RNP-8 enzyme is a broad-spectrum regulator of the oogenesis program that acts within an RNA regulatory network to specify and produce fully functional oocytes. ..
- Roy S, Clayton J, Holmen J, Beltz E, Saito R. Control of Cdc14 activity coordinates cell cycle and development in Caenorhabditis elegans. Mech Dev. 2011;128:317-26 pubmed publisher..We propose that these mechanisms collaborate to restrict the activity of cdc-14 as central components of an evolutionarily conserved regulatory network to coordinate cell-cycle progression with development. ..
- Tamayo J, Gujar M, Macdonald S, Lundquist E. Functional transcriptomic analysis of the role of MAB-5/Hox in Q neuroblast migration in Caenorhabditis elegans. BMC Genomics. 2013;14:304 pubmed publisher..The identities of the genes regulated by MAB-5 indicate that MAB-5 acts by modifying interactions with the basement membrane, resulting in posterior versus anterior migration. ..
- Gissendanner C, Kelley T. The C. elegans gene pan-1 encodes novel transmembrane and cytoplasmic leucine-rich repeat proteins and promotes molting and the larva to adult transition. BMC Dev Biol. 2013;13:21 pubmed publisher..We further demonstrate that the activity of PAN-1 is complex with diverse roles in the regulation of animal development. ..
- Rowley M, Nichols M, Lyu X, Ando Kuri M, Rivera I, Hermetz K, et al. Evolutionarily Conserved Principles Predict 3D Chromatin Organization. Mol Cell. 2017;67:837-852.e7 pubmed publisher..The results suggest that compartmental domains are responsible for domain structure in all eukaryotes, with CTCF playing an important role in domain formation in mammals. ..
- Haag E, Wang S, Kimble J. Rapid coevolution of the nematode sex-determining genes fem-3 and tra-2. Curr Biol. 2002;12:2035-41 pubmed..Extrapolation of this result to larger phylogenetic scales helps explain the dissimilarity of the sex determination systems across phyla. ..
- Anders K, Grimson A, Anderson P. SMG-5, required for C.elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A. EMBO J. 2003;22:641-50 pubmed..Our results suggest that PP2A is the SMG-2 phosphatase, and the role of SMG-5 is to direct PP2A to its SMG-2 substrate. We discuss cycles of SMG-2 phosphorylation and their roles in NMD. ..
- Kirouac M, Sternberg P. cis-Regulatory control of three cell fate-specific genes in vulval organogenesis of Caenorhabditis elegans and C. briggsae. Dev Biol. 2003;257:85-103 pubmed..By using the cis-regulatory analysis and phylogenetic footprinting, we have identified overrepresented sequences involved in conferring vulval and AC expression. ..
- Zinn K. Dendritic tiling; new insights from genetics. Neuron. 2004;44:211-3 pubmed..elegans. The tiling and ectopic branching phenotypes of trc mutants appear to be independently generated. Thus, this kinase is the first signaling protein to be associated specifically with tiling. ..
- Walston T, Tuskey C, Edgar L, Hawkins N, Ellis G, Bowerman B, et al. Multiple Wnt signaling pathways converge to orient the mitotic spindle in early C. elegans embryos. Dev Cell. 2004;7:831-41 pubmed
- Jauregui A, Barr M. Functional characterization of the C. elegans nephrocystins NPHP-1 and NPHP-4 and their role in cilia and male sensory behaviors. Exp Cell Res. 2005;305:333-42 pubmed..nphp-1; nphp-4 double, but not single, mutant males are response defective. We propose that NPHP-1 and NPHP-4 proteins play important and redundant roles in facilitating ciliary sensory signal transduction. ..
- Squirrell J, Eggers Z, Luedke N, Saari B, Grimson A, Lyons G, et al. CAR-1, a protein that localizes with the mRNA decapping component DCAP-1, is required for cytokinesis and ER organization in Caenorhabditis elegans embryos. Mol Biol Cell. 2006;17:336-44 pubmed..Thus, CAR-1, a protein likely to be associated with RNA metabolism, plays an essential role in the late stage of cytokinesis, suggesting a novel link between RNA, membrane trafficking and cytokinesis in the C. elegans embryo. ..
- Locke C, Kautu B, Berry K, Lee S, Caldwell K, Caldwell G. Pharmacogenetic analysis reveals a post-developmental role for Rac GTPases in Caenorhabditis elegans GABAergic neurotransmission. Genetics. 2009;183:1357-72 pubmed publisher..elegans. ..
- Zhao Z, Boyle T, Liu Z, Murray J, Wood W, Waterston R. A negative regulatory loop between microRNA and Hox gene controls posterior identities in Caenorhabditis elegans. PLoS Genet. 2010;6:e1001089 pubmed publisher..Given the conservation of the miRNA and Hox gene, the regulatory mechanism might be broadly used across species. The strategy used here to explore mir-57 function provides a path to dissect the regulatory relationship between genes. ..
- Chen B, Ge Q, Xia X, Liu P, Wang S, Zhan H, et al. A novel auxiliary subunit critical to BK channel function in Caenorhabditis elegans. J Neurosci. 2010;30:16651-61 pubmed publisher..Thus, BKIP-1 is a novel auxiliary subunit critical to SLO-1 function in vivo. ..
- Jastrzebska B, Salom D, Jin H, Cao P, Sun W, Palczewski K, et al. Expression of mammalian G protein-coupled receptors in Caenorhabditis elegans. Methods Enzymol. 2013;520:239-56 pubmed publisher..Here, we present a novel expression system for human GPCRs in Caenorhabditis elegans that produces sufficient amounts of recombinant proteins to allow their biochemical and structural characterization. ..
- Hajdu Cronin Y, Chen W, Patikoglou G, Koelle M, Sternberg P. Antagonism between G(o)alpha and G(q)alpha in Caenorhabditis elegans: the RGS protein EAT-16 is necessary for G(o)alpha signaling and regulates G(q)alpha activity. Genes Dev. 1999;13:1780-93 pubmed..elegans, and that G(o)alpha negatively regulates the G(q) pathway, possibly via EAT-16 or SAG-1. We propose that a major cellular role of G(o) is to antagonize signaling by G(q). ..
- Olsen P, Ambros V. The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation. Dev Biol. 1999;216:671-80 pubmed
- Severson A, Baillie D, Bowerman B. A Formin Homology protein and a profilin are required for cytokinesis and Arp2/3-independent assembly of cortical microfilaments in C. elegans. Curr Biol. 2002;12:2066-75 pubmed..These data suggest that CYK-1 and PFN-1 may nucleate MFs, as has recently been shown for an FH protein and a profilin in yeast. ..
- Yan N, Chai J, Lee E, Gu L, Liu Q, He J, et al. Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans. Nature. 2005;437:831-7 pubmed..The released CED-4 dimer further dimerizes to form a tetramer, which facilitates the autoactivation of CED-3. Together, our studies provide important insights into the regulation of cell death activation in C. elegans. ..
- Liu Y, Maine E. The Bro1-domain protein, EGO-2, promotes Notch signaling in Caenorhabditis elegans. Genetics. 2007;176:2265-77 pubmed..We document a complex phenotypic interaction between ego-2 and alx-1, consistent with their relationship being antagonistic with respect to some developmental processes and agonistic with respect to others. ..
- Lin K, Broitman Maduro G, Hung W, Cervantes S, Maduro M. Knockdown of SKN-1 and the Wnt effector TCF/POP-1 reveals differences in endomesoderm specification in C. briggsae as compared with C. elegans. Dev Biol. 2009;325:296-306 pubmed publisher..Our results suggest that integration of Wnt-dependent and Wnt-independent cell fate specification pathways within the Caenorhabditis genus can occur in different ways. ..
- Koh Y, Opperman L, Stumpf C, Mandan A, Keles S, Wickens M. A single C. elegans PUF protein binds RNA in multiple modes. RNA. 2009;15:1090-9 pubmed publisher..We propose a structural model in which flexibility in the central region of the protein enables the protein to adopt at least two distinct structures, one of which results in base flipping. ..
- Serang O, MacCoss M, Noble W. Efficient marginalization to compute protein posterior probabilities from shotgun mass spectrometry data. J Proteome Res. 2010;9:5346-57 pubmed publisher..We evaluate our identification procedure on five different well-characterized data sets and demonstrate our ability to efficiently compute high-quality protein posteriors. ..
- Myers E. G?o and G?q regulate the expression of daf-7, a TGF?-like gene, in Caenorhabditis elegans. PLoS ONE. 2012;7:e40368 pubmed publisher..This paper provides evidence that while goa-1 and egl-30 are important for normal daf-7 expression, mutations in these genes are not sufficient to disrupt dauer formation. ..
- Lynch A, Grana T, Cox Paulson E, Couthier A, Cameron M, Chin Sang I, et al. A genome-wide functional screen shows MAGI-1 is an L1CAM-dependent stabilizer of apical junctions in C. elegans. Curr Biol. 2012;22:1891-9 pubmed publisher..Our results further suggest that MAGI-1 helps to partition and maintain a stable, spatially ordered apical junction during morphogenesis...
- Huang L, Tzou P, Sternberg P. The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development. Mol Biol Cell. 1994;5:395-411 pubmed..We have identified a molecular null allele of lin-15 and have used it to analyze the role of lin-15 in the signaling pathway. We find that lin-15 acts upstream of let-23 and in parallel to the inductive signal. ..
- Garcia L, Mehta P, Sternberg P. Regulation of distinct muscle behaviors controls the C. elegans male's copulatory spicules during mating. Cell. 2001;107:777-88 pubmed..The male gonad then lengthens the duration of EGL-19-mediated prolonged muscle contraction. This regulation of muscle contraction provides a paradigm to explain how animals initiate, monitor, and maintain a behavioral motor program...
- Lyssenko N, Miteva Y, Gilroy S, Hanna Rose W, Schlegel R. An unexpectedly high degree of specialization and a widespread involvement in sterol metabolism among the C. elegans putative aminophospholipid translocases. BMC Dev Biol. 2008;8:96 pubmed publisher..These findings uncover an unexpectedly high degree of specialization and a widespread involvement in sterol metabolism among the genes encoding the putative aminophospholipid translocases. ..
- Sedensky M, Siefker J, Koh J, Miller D, Morgan P. A stomatin and a degenerin interact in lipid rafts of the nervous system of Caenorhabditis elegans. Am J Physiol Cell Physiol. 2004;287:C468-74 pubmed..Each of these mutations alters anesthetic sensitivity in C. elegans. Because lipid rafts contain many of the putative targets of volatile anesthetics, they may represent a novel class of targets for volatile anesthetics. ..
- Wang X, Greenberg J, Chamberlin H. Evolution of regulatory elements producing a conserved gene expression pattern in Caenorhabditis. Evol Dev. 2004;6:237-45 pubmed..elegans, with only one copy retaining the ability to regulate lin-48 in vivo. These results illustrate molecular changes that can occur despite maintenance of conserved gene function in different species. ..
- Hajdu Cronin Y, Chen W, Sternberg P. The L-type cyclin CYL-1 and the heat-shock-factor HSF-1 are required for heat-shock-induced protein expression in Caenorhabditis elegans. Genetics. 2004;168:1937-49 pubmed..hsf-1 encodes the C. elegans homolog of the human heat-shock factor HSF1, and cyl-1 encodes a cyclin most similar to cyclin L. We believe HSF-1 acts in heat-shock-inducible transcription and CYL-1 acts more generally in gene expression. ..
- Opperman L, Hook B, DeFino M, Bernstein D, Wickens M. A single spacer nucleotide determines the specificities of two mRNA regulatory proteins. Nat Struct Mol Biol. 2005;12:945-51 pubmed..We suggest that new specificities can be designed and selected using the PUF scaffold. ..
- Hu J, Bae Y, Knobel K, Barr M. Casein kinase II and calcineurin modulate TRPP function and ciliary localization. Mol Biol Cell. 2006;17:2200-11 pubmed..A dynamic phosphorylation-dephosphorylation cycle may represent a mechanism for modulating TRPP activity, cellular sensation, and ciliary protein localization. ..
- Sternberg P. Pathway to RAS. Genetics. 2006;172:727-31 pubmed
- Sedensky M, Morgan P. Mitochondrial respiration and reactive oxygen species in C. elegans. Exp Gerontol. 2006;41:957-67 pubmed..Taken as a group, these mutant strains indicate that metabolic rate, per se, only affects longevity indirectly. Mutations causing lowered metabolic rate potential are capable of decreasing or increasing longevity. ..
- Chen Y, Qiu S, Luan C, Luo M. Domain selection combined with improved cloning strategy for high throughput expression of higher eukaryotic proteins. BMC Biotechnol. 2007;7:45 pubmed..This platform will increase the success rate of purification and crystallization dramatically and promote the further advancement of structure genomics/proteomics. ..
- Johnson R, Chamberlin H. Positive and negative regulatory inputs restrict pax-6/vab-3 transcription to sensory organ precursors in Caenorhabditis elegans. Mech Dev. 2008;125:486-97 pubmed publisher..Thus we have identified multiple genetic pathways that act to restrict pax-6/vab-3 gene expression to the sensory organ precursor cells. ..
- Cheng H, Govindan J, Greenstein D. Regulated trafficking of the MSP/Eph receptor during oocyte meiotic maturation in C. elegans. Curr Biol. 2008;18:705-714 pubmed publisher..elegans. Eph receptor trafficking in other systems may be influenced by the conserved proteins DAB-1/Disabled and RAN-1 and by crosstalk with G protein signaling in neighboring cells. ..
- Shakir M, Jiang K, Struckhoff E, Demarco R, Patel F, Soto M, et al. The Arp2/3 activators WAVE and WASP have distinct genetic interactions with Rac GTPases in Caenorhabditis elegans axon guidance. Genetics. 2008;179:1957-71 pubmed publisher..These results indicate that at least three actin-modulating pathways act in parallel to control actin dynamics and lamellipodia and filopodia formation during axon guidance (WASP-WAVE, UNC-115/abLIM, and UNC-34/Enabled). ..
- Armstrong K, Chamberlin H. Coordinate regulation of gene expression in the C. elegans excretory cell by the POU domain protein CEH-6. Mol Genet Genomics. 2010;283:73-87 pubmed publisher..This work suggests that a role for POU-III factors in renal organs is to coordinate the expression of a set of functionally related genes. ..
- Nehme R, Grote P, Tomasi T, Loser S, Holzkamp H, Schnabel R, et al. Transcriptional upregulation of both egl-1 BH3-only and ced-3 caspase is required for the death of the male-specific CEM neurons. Cell Death Differ. 2010;17:1266-76 pubmed publisher..Finally, we present evidence that the timing of the death of the CEMs is controlled by TRA-1 Gli, the terminal global regulator of somatic sexual fate in C. elegans. ..
- Hale V, Guiney E, Goldberg L, Haduong J, Kwartler C, Scangos K, et al. Notch signaling is antagonized by SAO-1, a novel GYF-domain protein that interacts with the E3 ubiquitin ligase SEL-10 in Caenorhabditis elegans. Genetics. 2012;190:1043-57 pubmed publisher..This work provides the first mutant analysis of a GYF-domain protein in either C. elegans or Drosophila and introduces a new type of Fbw7-interacting protein that acts in a subset of Fbw7 functions. ..
- Seidel H, Kimble J. Cell-cycle quiescence maintains Caenorhabditis elegans germline stem cells independent of GLP-1/Notch. elife. 2015;4: pubmed publisher..Thus, cell-cycle quiescence can itself maintain stem cells, independent of the signaling pathway otherwise essential for such maintenance. ..
- Moss E, Lee R, Ambros V. The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA. Cell. 1997;88:637-46 pubmed..Deleting the LCE produces a dominant gain-of-function allele that causes a retarded phenotype, indicating that lin-28 activity is a switch that controls choices of stage-specific fates. ..
- Kamikura D, Cooper J. Lipoprotein receptors and a disabled family cytoplasmic adaptor protein regulate EGL-17/FGF export in C. elegans. Genes Dev. 2003;17:2798-811 pubmed..These results suggest a model in which Ce-DAB-1 coordinates selection of receptors and cargo, including EGL-17, for transport through the secretory pathway. ..
- Schindelman G, Whittaker A, Thum J, Gharib S, Sternberg P. Initiation of male sperm-transfer behavior in Caenorhabditis elegans requires input from the ventral nerve cord. BMC Biol. 2006;4:26 pubmed..The definition of circuit components is a crucial first step toward understanding how genes specify the neural circuit and hence the behavior. ..
- Vadakkadath Meethal S, Gallego M, Haasl R, Petras S, Sgro J, Atwood C. Identification of a gonadotropin-releasing hormone receptor orthologue in Caenorhabditis elegans. BMC Evol Biol. 2006;6:103 pubmed..elegans suggests the potential use of C. elegans as a model system to study reproductive endocrinology. ..
- Chesney M, Lam N, Morgan D, Phillips B, Kimble J. C. elegans HLH-2/E/Daughterless controls key regulatory cells during gonadogenesis. Dev Biol. 2009;331:14-25 pubmed publisher..We conclude that HLH-2 functions in both sexes to promote leader cell specification and DTC niche function. ..
- Nakayama Y, Shivas J, Poole D, Squirrell J, Kulkoski J, Schleede J, et al. Dynamin participates in the maintenance of anterior polarity in the Caenorhabditis elegans embryo. Dev Cell. 2009;16:889-900 pubmed publisher..Our results demonstrate a mechanism for the spatial and temporal regulation of endocytosis in the anterior of the embryo, contributing to the precise localization and maintenance of polarity factors within a dynamic plasma membrane. ..
- Wood J, Wang J, Benovic J, Ferkey D. Structural domains required for Caenorhabditis elegans G protein-coupled receptor kinase 2 (GRK-2) function in vivo. J Biol Chem. 2012;287:12634-44 pubmed publisher..Combined, we have demonstrated functional roles for broadly conserved GRK2/3 structural domains in the in vivo regulation of organismal behavior. ..
- Valley C, Porter D, Qiu C, Campbell Z, Hall T, Wickens M. Patterns and plasticity in RNA-protein interactions enable recruitment of multiple proteins through a single site. Proc Natl Acad Sci U S A. 2012;109:6054-9 pubmed publisher..This embedded information adds a new layer of biological meaning to the connections between RNA targets and PUF proteins. ..
- Bonner M, Han B, SKOP A. Profiling of the mammalian mitotic spindle proteome reveals an ER protein, OSTD-1, as being necessary for cell division and ER morphology. PLoS ONE. 2013;8:e77051 pubmed publisher..In addition, 65% of all ostd-1 RNAi-treated embryos failed to correctly position cleavage furrows, suggesting that proper ER morphology plays a necessary function during animal cell division. ..
- Feng H, Zhong W, Punkosdy G, Gu S, Zhou L, Seabolt E, et al. CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans. Nat Cell Biol. 1999;1:486-92 pubmed..In cul-2 mutant embryos, mitotic chromosomes are unable to condense, leading to unequal DNA segregation, chromosome bridging and the formation of multiple nuclei. ..
- Lin F, Fukuoka Y, Spicer A, Ohta R, Okada N, Harris C, et al. Tissue distribution of products of the mouse decay-accelerating factor (DAF) genes. Exploitation of a Daf1 knock-out mouse and site-specific monoclonal antibodies. Immunology. 2001;104:215-25 pubmed..The results have relevance for studies of in vivo murine DAF function and of murine DAF structure. ..
- Somerville R, Longpre J, Jungers K, Engle J, Ross M, Evanko S, et al. Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1. J Biol Chem. 2003;278:9503-13 pubmed
- Wang X, Chamberlin H. Evolutionary innovation of the excretory system in Caenorhabditis elegans. Nat Genet. 2004;36:231-2 pubmed..elegans result from the gain of expression of a single gene. Our results show that innovation can be achieved by altered expression of a transcription factor without coevolution of all target genes. ..
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