Genomes and Genes
Experts and Doctors on bone and bones in United Kingdom
Locale: United Kingdom
Topic: bone and bones
- Young M, Brusatte S, De Andrade M, Desojo J, Beatty B, Steel L, et al. The cranial osteology and feeding ecology of the metriorhynchid crocodylomorph genera Dakosaurus and Plesiosuchus from the late Jurassic of Europe. PLoS ONE. 2012;7:e44985 pubmed publisher..We hypothesise that trophic specialisation enabled these two large-bodied species to coexist in the same ecosystem. ..
- Wilson E, Garton M, Fuller H. Anti-epileptic drugs and bone loss: Phenytoin reduces pro-collagen I and alters the electrophoretic mobility of osteonectin in cultured bone cells. Epilepsy Res. 2016;122:97-101 pubmed publisher..The perturbation of these important bone proteins could be one of the mechanisms to explain the bone loss that has been reported following long-term treatment with phenytoin. ..
- Bassett J, Williams G. Role of Thyroid Hormones in Skeletal Development and Bone Maintenance. Endocr Rev. 2016;37:135-87 pubmed publisher..This review provides a comprehensive analysis of the current state of the art. ..
- ..This review discusses genomic and non-genomic actions of the androgen receptor, as well as their co-regulators. We also explore several clinically relevant aspects of the molecular biology of the androgen receptor and its co-regulators. ..
- Akbar R, Gosh S, Khalil S, ul Haq S. Zoledronic acid in metastatic bone disease: an audit based discussion. J Ayub Med Coll Abbottabad. 2010;22:5-7 pubmed..Poor documentation of data pertaining to Zoledronic acid treatment is observed which can potentially lead to major errors in prescribing. We recommend using a standard form to document each episode of therapy with Zoledronic acid. ..
- White H, Ahmad A, Durham B, Patwala A, Whittingham P, Fraser W, et al. Growth hormone replacement is important for the restoration of parathyroid hormone sensitivity and improvement in bone metabolism in older adult growth hormone-deficient patients. J Clin Endocrinol Metab. 2005;90:3371-80 pubmed..Their response appears delayed and may explain why previous studies have not shown a positive effect of GHR on bone mineral density in older AGHD patients. ..
- Brown J, Ellis S, Lester J, Gutcher S, Khanna T, Purohit O, et al. Prolonged efficacy of a single dose of the bisphosphonate zoledronic acid. Clin Cancer Res. 2007;13:5406-10 pubmed..Very infrequent administration of zoledronic acid may have clinical benefits in terms of convenience, reduced toxicity, improved compliance, and cost. ..
- Weinstock J, Willerslev E, Sher A, Tong W, Ho S, Rubenstein D, et al. Evolution, systematics, and phylogeography of pleistocene horses in the new world: a molecular perspective. PLoS Biol. 2005;3:e241 pubmed..Both caballine and stilt-legged lineages may each have comprised a single, wide-ranging species. ..
- Munday K, Ginty F, Fulford A, Bates C. Relationships between biochemical bone turnover markers, season, and inflammatory status indices in prepubertal Gambian boys. Calcif Tissue Int. 2006;79:15-21 pubmed..We conclude that bone collagen synthesis and turnover are reduced during inflammation in rural Gambian boys. Biochemical indices can provide powerful, single-time point evidence of infection and growth-faltering episodes. ..
- Theveneau E, Mayor R. Collective cell migration of the cephalic neural crest: the art of integrating information. Genesis. 2011;49:164-76 pubmed publisher..Therefore, understanding how CNC cells interpret multiple inputs to achieve directional collective cell migration will shed light on pathological situations where cell migration is involved. ..
- Abu E, Horner A, Kusec V, Triffitt J, Compston J. The localization of the functional glucocorticoid receptor alpha in human bone. J Clin Endocrinol Metab. 2000;85:883-9 pubmed..The absence of receptor expression in osteoclasts also suggests that the effects of glucocorticoids on bone resorption may be mediated indirectly. ..
- Zioupos P, Currey J, Casinos A. Exploring the effects of hypermineralisation in bone tissue by using an extreme biological example. Connect Tissue Res. 2000;41:229-48 pubmed
- Ralis Z, Watkins G. Modified tetrachrome method for osteoid and defectively mineralized bone in paraffin sections. Biotech Histochem. 1992;67:339-45 pubmed
- Draper E, Morris M, Camacho N, Matousek P, Towrie M, Parker A, et al. Novel assessment of bone using time-resolved transcutaneous Raman spectroscopy. J Bone Miner Res. 2005;20:1968-72 pubmed..After further optimization, this technology may help improve fracture risk assessments and open opportunities for screening in anticipation of the predicted increase in fragility fractures. ..
- Rees S, Shellis R, Embery G. Inhibition of hydroxyapatite crystal growth by bone proteoglycans and proteoglycan components. Biochem Biophys Res Commun. 2002;292:727-33 pubmed..This work provides new information regarding the role of bone SLRPs and their components in the regulation of the mineralisation process. ..
- Eaton S, Williamson C, Ball S, Beechey C, Moir L, Edwards J, et al. New mutations at the imprinted Gnas cluster show gene dosage effects of Gs? in postnatal growth and implicate XL?s in bone and fat metabolism but not in suckling. Mol Cell Biol. 2012;32:1017-29 pubmed publisher..This is, to our knowledge, the first report describing a role for XL?s in bone metabolism. We propose that XL?s is involved in the regulation of bone and adipocyte metabolism. ..
- Boulter C, Mulroy S, Webb S, Fleming S, Brindle K, Sandford R. Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene. Proc Natl Acad Sci U S A. 2001;98:12174-9 pubmed
- Wadia F, Shah N, Porter M. Bilateral charnley low-friction arthroplasty with cement in a patient with pyknodysostosis. A case report. J Bone Joint Surg Am. 2006;88:1846-8 pubmed
- Marom A, McCullagh J, Higham T, Sinitsyn A, Hedges R. Single amino acid radiocarbon dating of Upper Paleolithic modern humans. Proc Natl Acad Sci U S A. 2012;109:6878-81 pubmed publisher..These dates contribute considerably to our understanding of the emergence of the Mid-Upper Paleolithic and the complex suite of burial behaviors that begin to appear during this period. ..
- Bassett J, Nordstrom K, Boyde A, Howell P, Kelly S, Vennstrom B, et al. Thyroid status during skeletal development determines adult bone structure and mineralization. Mol Endocrinol. 2007;21:1893-904 pubmed..Thus, TRalpha1 regulates both skeletal development and adult bone maintenance, with euthyroid status during development being essential to establish normal adult bone structure and mineralization. ..
- Grewal T, Genever P, Brabbs A, Birch M, Skerry T. Best5: a novel interferon-inducible gene expressed during bone formation. FASEB J. 2000;14:523-31 pubmed..These findings highlight the close interactions between the immune system and bone cells and may open new therapeutic avenues in modulating bone mass. ..
- Pimanda J, Silberstein L, Dominici M, Dekel B, Bowen M, Oldham S, et al. Transcriptional link between blood and bone: the stem cell leukemia gene and its +19 stem cell enhancer are active in bone cells. Mol Cell Biol. 2006;26:2615-25 pubmed
- Bassett J, Boyde A, Howell P, Bassett R, Galliford T, Archanco M, et al. Optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts. Proc Natl Acad Sci U S A. 2010;107:7604-9 pubmed publisher..These data reveal an essential role for D2 in osteoblasts in the optimization of bone strength and mineralization. ..
- Currey J. Mechanical properties and adaptations of some less familiar bony tissues. J Mech Behav Biomed Mater. 2010;3:357-72 pubmed publisher..There is a pressing need for an examination of some material properties of a whole variety of bones, always using exactly the same testing method, for instance nanoindentation of wet material, so that firm comparisons can be made. ..
- Whyte L, Ryberg E, Sims N, Ridge S, Mackie K, Greasley P, et al. The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo. Proc Natl Acad Sci U S A. 2009;106:16511-6 pubmed publisher..In addition, this study also brings to light an effect of both the endogenous ligand, LPI, on osteoclasts and of the cannabis constituent, CBD, on osteoclasts and bone turnover in vivo. ..
- Hutchinson J, Bates K, Molnar J, Allen V, Makovicky P. A computational analysis of limb and body dimensions in Tyrannosaurus rex with implications for locomotion, ontogeny, and growth. PLoS ONE. 2011;6:e26037 pubmed publisher..Overall, the limb "antigravity" muscles may have been as large as or even larger than those of ratite birds, which themselves have the most muscular limbs of any living animal...
- Lindsay S, Johnstone S, Mountford J, Sheikh S, Allan D, Clark L, et al. Human mesenchymal stem cells isolated from olfactory biopsies but not bone enhance CNS myelination in vitro. Glia. 2013;61:368-82 pubmed publisher..Thus LP-MSCs harvested from human OM biopsies may be an important candidate for cell transplantation by contributing to the repair of SCI. ..
- Singhatanadgit W, Salih V, Olsen I. Shedding of a soluble form of BMP receptor-IB controls bone cell responses to BMP. Bone. 2006;39:1008-1017 pubmed publisher..In conclusion, our study has provided evidence, for the first time, that BMPR can be modulated at the cell surface by the shedding of a soluble form of the antigen, resulting in a markedly diminished response to BMP-2 in vitro. ..
- Wong J, Marsh D, Abu Sitta G, Lau S, Mann H, Nawabi D, et al. Biological foreign body implantation in victims of the London July 7th suicide bombings. J Trauma. 2006;60:402-4 pubmed
- Leitch V, Di Cosmo C, Liao X, O Boy S, Galliford T, Evans H, et al. An Essential Physiological Role for MCT8 in Bone in Male Mice. Endocrinology. 2017;158:3055-3066 pubmed publisher..These studies identify an essential physiological requirement for MCT8 in chondrocytes, and demonstrate a role for additional transporters in other skeletal cells during adult bone maintenance. ..
- Gonzalez Rodriguez J, Fowler G. A study on the discrimination of human skeletons using X-ray fluorescence and chemometric tools in chemical anthropology. Forensic Sci Int. 2013;231:407.e1-6 pubmed publisher..Also, two new elemental ratios, Zn/Fe related to metabolic activities and K/Fe related to blood flow into the bone, have been defined for their use in forensic anthropology for the first time to aid in the separation. ..
- van t Hof R, Macphee J, Libouban H, Helfrich M, Ralston S. Regulation of bone mass and bone turnover by neuronal nitric oxide synthase. Endocrinology. 2004;145:5068-74 pubmed..The low level of nNOS expression in bone and the in vitro behavior of nNOS KO bone cells indicate that these actions are indirect and possibly mediated by a neurogenic relay. ..
- Owen R, Sherborne C, Paterson T, Green N, Reilly G, Claeyssens F. Emulsion templated scaffolds with tunable mechanical properties for bone tissue engineering. J Mech Behav Biomed Mater. 2016;54:159-72 pubmed publisher..The scaffolds supported osteogenic differentiation of mesenchymal cells and interestingly, the stiffest IBOA-based scaffolds that were plasma treated with acrylic acid promoted osteogenesis more strongly than the other scaffolds. ..
- Yarram S, Perry M, Christopher T, Westby K, Brown N, Lamminen T, et al. Luteinizing hormone receptor knockout (LuRKO) mice and transgenic human chorionic gonadotropin (hCG)-overexpressing mice (hCG alphabeta+) have bone phenotypes. Endocrinology. 2003;144:3555-64 pubmed..Although gonadotropin levels are tightly linked to sex steroid titers, it appears that their effects on the skeleton are indirect. ..
- Macfarlane S, Seatter M, Kanke T, Hunter G, Plevin R. Proteinase-activated receptors. Pharmacol Rev. 2001;53:245-82 pubmed..The future identification of other PARs and their modes of activation are an important future direction for this expanding field of study. ..
- Tare R, Oreffo R, Clarke N, Roach H. Pleiotrophin/Osteoblast-stimulating factor 1: dissecting its diverse functions in bone formation. J Bone Miner Res. 2002;17:2009-20 pubmed..PTN enhances or inhibits primary responses depending on the prevailing concentrations, the primary stimulus, and the availability of appropriate receptors. ..
- Schmidt K, Hughes C, Chudek J, Goodyear S, Aspden R, Talbot R, et al. Cholesterol metabolism: the main pathway acting downstream of cytochrome P450 oxidoreductase in skeletal development of the limb. Mol Cell Biol. 2009;29:2716-29 pubmed publisher..Thus, cellular POR-dependent cholesterol synthesis is essential during limb and skeletal development. Modulation of P450 activity could contribute to susceptibility of the embryo and developing organs to teratogenesis. ..
- Chong D, Hansen U, van der Venne R, Verdonschot N, Amis A. The influence of tibial component fixation techniques on resorption of supporting bone stock after total knee replacement. J Biomech. 2011;44:948-54 pubmed publisher..Specifically, the hybrid cementing fixation induced the least amount of bone resorption. ..
- Collins E, Appert A, Ariza McNaughton L, Pannell R, Yamada Y, Rabbitts T. Mouse Af9 is a controller of embryo patterning, like Mll, whose human homologue fuses with Af9 after chromosomal translocation in leukemia. Mol Cell Biol. 2002;22:7313-24 pubmed..This is analogous to the role of Mll, the murine homolog of human MLL, to which the Af9 gene fuses in acute myeloid leukemias. ..
- O Shea P, Harvey C, Suzuki H, Kaneshige M, Kaneshige K, Cheng S, et al. A thyrotoxic skeletal phenotype of advanced bone formation in mice with resistance to thyroid hormone. Mol Endocrinol. 2003;17:1410-24 pubmed..Thus, the skeleton in TRbetaPV/PV mice is thyrotoxic and displays phenotypic features typical of juvenile hyperthyroidism. ..
- Cooper M, Blumsohn A, Goddard P, Bartlett W, Shackleton C, Eastell R, et al. 11beta-hydroxysteroid dehydrogenase type 1 activity predicts the effects of glucocorticoids on bone. J Clin Endocrinol Metab. 2003;88:3874-7 pubmed..Measures of 11beta-HSD1 activity may predict individual susceptibility to glucocorticoid-induced osteoporosis, and these data should facilitate the development of bone-sparing glucocorticoids. ..
- Bassett J, Logan J, Boyde A, Cheung M, Evans H, Croucher P, et al. Mice lacking the calcineurin inhibitor Rcan2 have an isolated defect of osteoblast function. Endocrinology. 2012;153:3537-48 pubmed publisher..Overall, these studies establish that Rcan2 regulates osteoblast function and its expression in bone is regulated by thyroid status in vivo. ..
- Sutherland H, Newton K, Brownstein D, Holmes M, Kress C, Semple C, et al. Disruption of Ledgf/Psip1 results in perinatal mortality and homeotic skeletal transformations. Mol Cell Biol. 2006;26:7201-10 pubmed..The latter phenotypes suggest a role for Psip1 in the control of Hox expression and may also explain why PSIP1 (LEDGF) is found as a fusion partner with NUP98 in myeloid leukemias. ..
- Stewart A, Roberts S, Seawright E, Davey M, Fleming R, Farquharson C. The presence of PHOSPHO1 in matrix vesicles and its developmental expression prior to skeletal mineralization. Bone. 2006;39:1000-1007 pubmed publisher..These studies provide for the first time direct evidence that PHOSPHO1 is present in MVs, and its developmental expression pattern is consistent with a role in the early stages of matrix mineralization. ..
- O Shea P, Bassett J, Sriskantharajah S, Ying H, Cheng S, Williams G. Contrasting skeletal phenotypes in mice with an identical mutation targeted to thyroid hormone receptor alpha1 or beta. Mol Endocrinol. 2005;19:3045-59 pubmed..These studies provide a new understanding of the complex relationship between central and peripheral thyroid status. ..
- Hill P, Tumber A, Papaioannou S, Meikle M. The cellular actions of interleukin-11 on bone resorption in vitro. Endocrinology. 1998;139:1564-72 pubmed..Our data also suggest that the stimulatory effects of IL-11 involve both MMPs and products of arachidonic acid metabolism. ..
- Paschou S, Dede A, Anagnostis P, Vryonidou A, Morganstein D, Goulis D. Type 2 Diabetes and Osteoporosis: A Guide to Optimal Management. J Clin Endocrinol Metab. 2017;102:3621-3634 pubmed publisher..Patients with coexisting T2D and osteoporosis should be managed in an optimal way according to scientific evidence. ..
- Mushtaq T, Bijman P, Ahmed S, Farquharson C. Insulin-like growth factor-I augments chondrocyte hypertrophy and reverses glucocorticoid-mediated growth retardation in fetal mice metatarsal cultures. Endocrinology. 2004;145:2478-86 pubmed..However, the IGF-I-mediated improvement in growth was at the expense of altering the balance between proliferating and hypertrophic chondrocytes within the metatarsal...
- Minguillon C, Del Buono J, Logan M. Tbx5 and Tbx4 are not sufficient to determine limb-specific morphologies but have common roles in initiating limb outgrowth. Dev Cell. 2005;8:75-84 pubmed..We propose a model in which positional codes, such as Pitx1 and Hox genes in the lateral plate mesoderm, dictate limb-specific morphologies. ..
- Bassett J, O Shea P, Sriskantharajah S, Rabier B, Boyde A, Howell P, et al. Thyroid hormone excess rather than thyrotropin deficiency induces osteoporosis in hyperthyroidism. Mol Endocrinol. 2007;21:1095-107 pubmed..These studies demonstrate that bone loss in thyrotoxicosis is independent of circulating TSH levels and mediated predominantly by TRalpha, thus identifying TRalpha as a novel drug target in the prevention and treatment of osteoporosis. ..
- Evans S, Jones M, Krause D. A giant frog with South American affinities from the Late Cretaceous of Madagascar. Proc Natl Acad Sci U S A. 2008;105:2951-6 pubmed publisher..It also suggests that the initial radiation of hyloid anurans began earlier than proposed by some recent estimates. ..
- Mills C, Pain M, Yeadon M. Reducing ground reaction forces in gymnastics' landings may increase internal loading. J Biomech. 2009;42:671-8 pubmed publisher..However, using a reduction in GRF, due to a change in landing strategy, as a basis for a reduction in injury potential in vaulting movements may not be appropriate since internal loading can increase. ..
- Sunters A, Armstrong V, Zaman G, Kypta R, Kawano Y, Lanyon L, et al. Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 r. J Biol Chem. 2010;285:8743-58 pubmed publisher..This cascade requires prostanoid/nitric oxide production and is independent of Wnt/LRP5. ..
- Orriss I, Wang N, Burnstock G, Arnett T, Gartland A, Robaye B, et al. The P2Y(6) receptor stimulates bone resorption by osteoclasts. Endocrinology. 2011;152:3706-16 pubmed publisher..Taken together these results show the P2Y(6) receptor may play an important role in the regulation of bone cell function in vivo...
- Anderson R, Cameron D. Pretreatment serum anti-müllerian hormone predicts long-term ovarian function and bone mass after chemotherapy for early breast cancer. J Clin Endocrinol Metab. 2011;96:1336-43 pubmed publisher..However, age is the only patient characteristic currently recognized to be predictive of long-term ovarian function after chemotherapy...