Experts and Doctors on biomarkers in United States

Summary

Locale: United States
Topic: biomarkers

Top Publications

  1. Grodin J, Gallup D, Anstrom K, Felker G, Chen H, Tang W. Implications of Alternative Hepatorenal Prognostic Scoring Systems in Acute Heart Failure (from DOSE-AHF and ROSE-AHF). Am J Cardiol. 2017;119:2003-2009 pubmed publisher
    ..However, MELD-Na and MELD-XI were not predictive of 60-day clinical events. ..
  2. Haworth K, Chandler H. Oxidative Stress Measures of Lipid and DNA Damage in Human Tears. Invest Ophthalmol Vis Sci. 2017;58:BIO151-BIO157 pubmed publisher
    ..Seasonal temperature variation and other factors may influence tear lipid peroxidation. Support is demonstrated to suggest lipid damage and DNA damage occur concurrently on the human ocular surface. ..
  3. Joutsa J, Rinne J, Hermann B, Karrasch M, Anttinen A, Shinnar S, et al. Association Between Childhood-Onset Epilepsy and Amyloid Burden 5 Decades Later. JAMA Neurol. 2017;74:583-590 pubmed publisher
    ..Thus, epilepsy is linked with a biomarker that might be related to accelerated brain aging and can be considered a neurobiological predisposition to later-life cognitive disorders. ..
  4. Ferrante R, Browne S, Shinobu L, Bowling A, Baik M, MacGarvey U, et al. Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis. J Neurochem. 1997;69:2064-74 pubmed
    ..These studies therefore provide further evidence that oxidative damage may play a role in the pathogenesis of neuronal degeneration in both SALS and FALS. ..
  5. Cajaiba M, North P, Gong S, Dickman P, Mroczek Musulman E, Sauer D, et al. Congenital capillary proliferation of the kidney: a distinctive renal vascular lesion of childhood. Hum Pathol. 2017;66:59-66 pubmed publisher
  6. Gendron T, Daughrity L, Heckman M, Diehl N, Wuu J, Miller T, et al. Phosphorylated neurofilament heavy chain: A biomarker of survival for C9ORF72-associated amyotrophic lateral sclerosis. Ann Neurol. 2017;82:139-146 pubmed publisher
    ..These data support the use of CSF pNFH as a prognostic biomarker for clinical trials, which will increase the likelihood of successfully developing a treatment for c9ALS. Ann Neurol 2017;82:139-146. ..
  7. Rodriguez Gutierrez R, Shah N, Montori V. Predicting the Overuse of PCSK-9 Inhibitors. JAMA. 2015;314:1909-10 pubmed publisher
  8. DeLeon Pennell K, Meschiari C, Jung M, Lindsey M. Matrix Metalloproteinases in Myocardial Infarction and Heart Failure. Prog Mol Biol Transl Sci. 2017;147:75-100 pubmed publisher
    ..This chapter focuses on the role of MMPs post-MI, the efficiency of MMPs as biomarkers for MI or heart failure, and the future of MMPs and their cleavage products as targets for prevention of post-MI heart failure. ..
  9. Brown J, Samaha E, Rao S, Helwani M, Duma A, Brown F, et al. High-Sensitivity Cardiac Troponin T Improves the Diagnosis of Perioperative MI. Anesth Analg. 2017;125:1455-1462 pubmed publisher
    ..The use of hscTnT compared to contemporary cTnI increases the detection rate of perioperative MI by a factor of 2. Using different absolute or relative hscTnT change metrics may lead to under- or overdiagnosis of perioperative MI. ..

More Information

Publications179 found, 100 shown here

  1. Meyerholz D, Ofori Amanfo G, Leidinger M, Goeken J, Khanna R, Sieren J, et al. Immunohistochemical Markers for Prospective Studies in Neurofibromatosis-1 Porcine Models. J Histochem Cytochem. 2017;65:607-618 pubmed publisher
    ..Validation of these markers on fixed tissues will facilitate prospective immunohistochemical studies of NF1 pigs, as well as other pig models, in a more efficient, reproducible, and translationally relevant manner. ..
  2. Bagai A, Alexander K, Berger J, Senior R, Sajeev C, Pracon R, et al. Use of troponin assay 99th percentile as the decision level for myocardial infarction diagnosis. Am Heart J. 2017;190:135-139 pubmed publisher
    ..This variability across laboratories has important implications for both the diagnosis of myocardial infarction in clinical practice as well as adjudication of myocardial infarction in clinical trials. ..
  3. Cao J, Singh S, McClung J, Joseph G, Vanella L, Barbagallo I, et al. EET intervention on Wnt1, NOV, and HO-1 signaling prevents obesity-induced cardiomyopathy in obese mice. Am J Physiol Heart Circ Physiol. 2017;313:H368-H380 pubmed publisher
    ..Listen to this article's corresponding podcast at http://ajpheart.physiology.org/content/early/2017/05/31/ajpheart.00093.2017. ..
  4. Hoye M, Koval E, Wegener A, Hyman T, Yang C, O Brien D, et al. MicroRNA Profiling Reveals Marker of Motor Neuron Disease in ALS Models. J Neurosci. 2017;37:5574-5586 pubmed publisher
    ..Furthermore, rats treated with ALS therapy have restored expression of this MN RNA marker, making it an MN-specific and drug-responsive marker for ALS rodents. ..
  5. FIELDS M, Bowrey H, Gong J, Moreira E, Cai H, Del Priore L. Extracellular matrix nitration alters growth factor release and activates bioactive complement in human retinal pigment epithelial cells. PLoS ONE. 2017;12:e0177763 pubmed publisher
    ..This model demonstrates changes seen in the basement membrane can lead to alterations in the cell biology of the RPE cells that may be related to the development of age-related macular degeneration. ..
  6. Januzzi J, Butler J, Jarolim P, Sattar N, Vijapurkar U, Desai M, et al. Effects of Canagliflozin on Cardiovascular Biomarkers in Older Adults With Type 2 Diabetes. J Am Coll Cardiol. 2017;70:704-712 pubmed publisher
    ..A Safety and Efficacy Study of Canagliflozin in Older Patients [55 to 80 Years of Age] With Type 2 Diabetes Mellitus; NCT01106651). ..
  7. Omar H, Charnigo R, Guglin M. Prognostic Significance of Discharge Hyponatremia in Heart Failure Patients With Normal Admission Sodium (from the ESCAPE Trial). Am J Cardiol. 2017;120:607-615 pubmed publisher
    ..045). Because the median discharge Na level in the discharge hyponatremia group was 132 meq/L, our findings suggest a benign nature of mild discharge hyponatremia in HF patients with normal admission Na. ..
  8. Zaslavsky O, Zelber Sagi S, Hebert J, Steck S, Shivappa N, Tabung F, et al. Biomarker-calibrated nutrient intake and healthy diet index associations with mortality risks among older and frail women from the Women's Health Initiative. Am J Clin Nutr. 2017;105:1399-1407 pubmed publisher
    ..b>Conclusions: The current study highlights the importance of nutrition in older, frail women. Diet quality and quantity should be considered in managing persons with frailty. ..
  9. Al Rifai M, DeFilippis A, McEvoy J, Hall M, Acien A, Jones M, et al. The relationship between smoking intensity and subclinical cardiovascular injury: The Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2017;258:119-130 pubmed publisher
    ..In percent change analyses, relationships were strongest with hsCRP. Smoking intensity was associated with early biomarkers of CVD, particularly, markers of systemic inflammation. Of these, hsCRP may be the most sensitive. ..
  10. Dervieux T, Conklin J, Ligayon J, Wolover L, O Malley T, Alexander R, et al. Validation of a multi-analyte panel with cell-bound complement activation products for systemic lupus erythematosus. J Immunol Methods. 2017;446:54-59 pubmed publisher
    ..The incidence of 2-tiered positive test results is 13.4%. We have established the analytical validity of a multi-analyte assay panel for SLE. ..
  11. Schork N. Personalized medicine: Time for one-person trials. Nature. 2015;520:609-11 pubmed publisher
  12. Crowell K, Phillips B, Kelleher S, Soybel D, Lang C. Immune and metabolic responses in early and late sepsis during mild dietary zinc restriction. J Surg Res. 2017;210:47-58 pubmed publisher
    ..Without increasing mortality, the ZM state is associated with a more disordered acute systemic inflammatory response and persistence or enhancement of acute phase responses within the liver parenchyma. ..
  13. Cochrane A, CHEUNG C, Rangan K, Freyer D, Nahata L, Dhall G, et al. Long-term follow-up of endocrine function among young children with newly diagnosed malignant central nervous system tumors treated with irradiation-avoiding regimens. Pediatr Blood Cancer. 2017;64: pubmed publisher
    ..These findings demonstrate that the use of relatively brief, intensive chemotherapy regimens including marrow-ablative chemotherapy with AuHCR results in fewer endocrine sequelae than treatment schemes utilizing CNS irradiation. ..
  14. Aluganti Narasimhulu C, Nandave M, Bonilla D, Singaravelu J, Sai Sudhakar C, Parthasarathy S. Circulating platelet aggregates damage endothelial cells in culture. J Surg Res. 2017;213:90-99 pubmed publisher
    ..Direct mechanical disruption and shear stress caused by circulating AgPlts could be the underlying mechanism of the observed endothelium damage. ..
  15. Levis B, Binkley P, Shapiro C. Cardiotoxic effects of anthracycline-based therapy: what is the evidence and what are the potential harms?. Lancet Oncol. 2017;18:e445-e456 pubmed publisher
  16. Schechter M, Buac K, Adekambi T, Cagle S, Celli J, Ray S, et al. Neutrophil extracellular trap (NET) levels in human plasma are associated with active TB. PLoS ONE. 2017;12:e0182587 pubmed publisher
    ..We show that plasma NETs levels at baseline correlated with disease severity and decreased with antibiotic therapy. Our study demonstrates the biologic plausibility of measuring NETs in plasma samples from patients with TB. ..
  17. Xing J, Spradling P, Moorman A, Holmberg S, Teshale E, Rupp L, et al. A Point System to Forecast Hepatocellular Carcinoma Risk Before and After Treatment Among Persons with Chronic Hepatitis C. Dig Dis Sci. 2017;62:3221-3234 pubmed publisher
    ..87). This scoring system, based on age, alcohol abuse history, treatment response, and APRI, can be used to forecast up to a 5-year risk of HCC among hepatitis C patients before and after SVR. ..
  18. Pauza C, Trivedi P, McKechnie T, Richman D, Graziano F. 2-LTR circular viral DNA as a marker for human immunodeficiency virus type 1 infection in vivo. Virology. 1994;205:470-8 pubmed
    ..Similar correlations were not observed in patients receiving zidovudine (AZT), didanosine (ddA), or zalcitabine (ddC). ..
  19. Jaffar J, Unger S, Corte T, Keller M, Wolters P, Richeldi L, et al. Fibulin-1 predicts disease progression in patients with idiopathic pulmonary fibrosis. Chest. 2014;146:1055-1063 pubmed publisher
    ..71; 95% CI, 0.57-0.86; P = .012). Fibulin-1 is a novel potential biomarker for disease progression in IPF and raises the possibility that it could be used as a target for the development of new treatments. ..
  20. Cho H, Kim H, Park J, Park S, Kim K, Wood T, et al. Construction and characterization of the Korean whole saliva proteome to determine ethnic differences in human saliva proteome. PLoS ONE. 2017;12:e0181765 pubmed publisher
    ..Finally, the present Korean WS protein list can serve as the first level reference for future proteomic studies including disease biomarker studies on Korean saliva. ..
  21. Quick E, Seitz S, Clarke P, Tyler K. Minocycline Has Anti-inflammatory Effects and Reduces Cytotoxicity in an Ex Vivo Spinal Cord Slice Culture Model of West Nile Virus Infection. J Virol. 2017;91: pubmed publisher
  22. Qi L, Ma W, Heianza Y, Zheng Y, Wang T, Sun D, et al. Independent and Synergistic Associations of Biomarkers of Vitamin D Status With Risk of Coronary Heart Disease. Arterioscler Thromb Vasc Biol. 2017;37:2204-2212 pubmed publisher
    ..VDBP but not bioavailable 25OHD was independently associated with lower CHD risk. ..
  23. Kim Campbell N, Gretchen C, Callaway C, Felmet K, Kochanek P, Maul T, et al. Cell-Free Plasma Hemoglobin and Male Gender Are Risk Factors for Acute Kidney Injury in Low Risk Children Undergoing Cardiopulmonary Bypass. Crit Care Med. 2017;45:e1123-e1130 pubmed publisher
    ..Further studies are needed to determine whether specific subgroups of pediatric patients undergoing cardiopulmonary bypass would benefit from potential treatments for hemolysis and plasma hemoglobin-associated renal dysfunction. ..
  24. Skikne B, Flowers C, Cook J. Serum transferrin receptor: a quantitative measure of tissue iron deficiency. Blood. 1990;75:1870-6 pubmed
  25. Nixon D, Bosch R, Chan E, Funderburg N, Hodder S, Lake J, et al. Effects of atorvastatin on biomarkers of immune activation, inflammation, and lipids in virologically suppressed, human immunodeficiency virus-1-infected individuals with low-density lipoprotein cholesterol <130 mg/dL (AIDS Clinical Trials Group S. J Clin Lipidol. 2017;11:61-69 pubmed publisher
  26. Engle Stone R, Aaron G, Huang J, Wirth J, Namaste S, Williams A, et al. Predictors of anemia in preschool children: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project. Am J Clin Nutr. 2017;106:402S-415S pubmed publisher
    ..The relative importance of factors that are associated with anemia varies by setting, and thus, country-specific data are needed to guide programs. ..
  27. Dai Y, Molazemhosseini A, Liu C. In Vitro Quantified Determination of ?-Amyloid 42 Peptides, a Biomarker of Neuro-Degenerative Disorders, in PBS and Human Serum Using a Simple, Cost-Effective Thin Gold Film Biosensor. Biosensors (Basel). 2017;7: pubmed publisher
    ..Interference study of this biosensor was carried out in the presence of Tau protein antigen. Excellent specificity of this ?-amyloid 42 biosensor was demonstrated without interference from other species, such as T-tau protein. ..
  28. Everett S, Vishwanath S, Cavero V, Shen L, Suresh L, Malyavantham K, et al. Analysis of novel Sjogren's syndrome autoantibodies in patients with dry eyes. BMC Ophthalmol. 2017;17:20 pubmed publisher
    ..This will lead to improved management of the patients and the development of new strategies to maintain normal lacrimal and salivary gland function in patients with SS. ..
  29. Arbelaiz A, Azkargorta M, Krawczyk M, Santos Laso A, Lapitz A, Perugorria M, et al. Serum extracellular vesicles contain protein biomarkers for primary sclerosing cholangitis and cholangiocarcinoma. Hepatology. 2017;66:1125-1143 pubmed publisher
    ..Proteomic signatures found in serum EV of CCA, PSC, and HCC patients show potential usefulness as diagnostic tools. (Hepatology 2017;66:1125-1143). ..
  30. Solazzo C, FitzHugh W, Kaplan S, Potter C, Dyer J. Molecular markers in keratins from Mysticeti whales for species identification of baleen in museum and archaeological collections. PLoS ONE. 2017;12:e0183053 pubmed publisher
  31. Nielsen T, Pantapalangkoor P, Luna B, Bruhn K, Yan J, Dekitani K, et al. Monoclonal Antibody Protects Against Acinetobacter baumannii Infection by Enhancing Bacterial Clearance and Evading Sepsis. J Infect Dis. 2017;216:489-501 pubmed publisher
    ..We describe a promising and novel mAb as therapy for lethal, XDR A. baumannii infections, and demonstrate that it synergistically improves outcomes in combination with antibiotics. ..
  32. Niss O, Fleck R, Makue F, Alsaied T, Desai P, Towbin J, et al. Association between diffuse myocardial fibrosis and diastolic dysfunction in sickle cell anemia. Blood. 2017;130:205-213 pubmed publisher
    ..Diffuse myocardial fibrosis is a novel mechanism that appears to underlie diastolic dysfunction in SCA. ..
  33. Hensley K, Hall N, Subramaniam R, Cole P, Harris M, Aksenov M, et al. Brain regional correspondence between Alzheimer's disease histopathology and biomarkers of protein oxidation. J Neurochem. 1995;65:2146-56 pubmed
    ..These data indicate that senile plaque-dense regions of the AD brain may represent environments of elevated oxidative stress. ..
  34. Sato Y, Tanino Y, Wang X, Nikaido T, Sato S, Misa K, et al. Baseline serum syndecan-4 predicts prognosis after the onset of acute exacerbation of idiopathic interstitial pneumonia. PLoS ONE. 2017;12:e0176789 pubmed publisher
    ..Baseline serum syndecan-4 is a possible prognostic biomarker after the onset of acute exacerbation of idiopathic interstitial pneumonia. ..
  35. Latimer C, Keene C, Flanagan M, Hemmy L, Lim K, White L, et al. Resistance to Alzheimer Disease Neuropathologic Changes and Apparent Cognitive Resilience in the Nun and Honolulu-Asia Aging Studies. J Neuropathol Exp Neurol. 2017;76:458-466 pubmed publisher
    ..Future in vivo validation of these results awaits comprehensive biomarkers of these 4 brain diseases. ..
  36. Li M, Zeringer E, Barta T, Schageman J, Cheng A, Vlassov A. Analysis of the RNA content of the exosomes derived from blood serum and urine and its potential as biomarkers. Philos Trans R Soc Lond B Biol Sci. 2014;369: pubmed publisher
    ..The value of exosomes for clinical applications is discussed with an emphasis on their potential for diagnosing and treating neurodegenerative diseases and brain cancer. ..
  37. Svedova J, Menoret A, Mittal P, Ryan J, Buturla J, Vella A. Therapeutic blockade of CD54 attenuates pulmonary barrier damage in T cell-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2017;313:L177-L191 pubmed publisher
    ..Thus CD54-targeted therapy may be a promising candidate for further exploration into its potential utility in treating ARDS patients. ..
  38. Gidding S, Bacha F, Bjornstad P, Levitt Katz L, Levitsky L, Lynch J, et al. Cardiac Biomarkers in Youth with Type 2 Diabetes Mellitus: Results from the TODAY Study. J Pediatr. 2018;192:86-92.e5 pubmed publisher
    ..Elevated serum concentrations of cardiac biomarkers were common in youth with type 2 diabetes, but their clinical significance is unclear and will require further long-term study. ClinicalTrials.govNCT00081328. ..
  39. Kim K, Bloom M, Fujimoto V, Browne R. Number of specimens required to estimate average follicular fluid high-density lipoprotein particle components in women undergoing in vitro fertilization. Fertil Steril. 2014;101:e44 pubmed publisher
  40. Price N, Magis A, Earls J, Glusman G, Levy R, Lausted C, et al. A wellness study of 108 individuals using personal, dense, dynamic data clouds. Nat Biotechnol. 2017;35:747-756 pubmed publisher
    ..Our results show that measurement of personal data clouds over time can improve our understanding of health and disease, including early transitions to disease states. ..
  41. Rini B. Biomarkers: hypertension following anti-angiogenesis therapy. Clin Adv Hematol Oncol. 2010;8:415-6 pubmed
  42. Shen Y, Huang G, McCormick B, Song T, Xu X. Effects of high-intensity interval versus mild-intensity endurance training on metabolic phenotype and corticosterone response in rats fed a high-fat or control diet. PLoS ONE. 2017;12:e0181684 pubmed publisher
    ..Compared with ME training, HI training contributes to greater improvements in metabolic and corticosterone responses, leading to a greater reduction in susceptibility to HFD-induced disorders. ..
  43. Caballero S, Kent D, Sengupta N, Li Calzi S, Shaw L, Beli E, et al. Bone Marrow-Derived Cell Recruitment to the Neurosensory Retina and Retinal Pigment Epithelial Cell Layer Following Subthreshold Retinal Phototherapy. Invest Ophthalmol Vis Sci. 2017;58:5164-5176 pubmed publisher
    ..We investigated whether subthreshold retinal phototherapy (SRPT) was associated with recruitment of bone marrow (BM)-derived cells to the neurosensory retina (NSR) and RPE layer...
  44. Kirkland J, Tchkonia T. Cellular Senescence: A Translational Perspective. EBioMedicine. 2017;21:21-28 pubmed publisher
    ..Several senolytic agents, which appear to alleviate multiple senescence-related phenotypes in pre-clinical models, are beginning the process of being translated into clinical interventions that could be transformative. ..
  45. Csongradi E, Kaplar M, Nagy B, Koch C, Juhasz A, Bajnok L, et al. Adipokines as atherothrombotic risk factors in obese subjects: Associations with haemostatic markers and common carotid wall thickness. Nutr Metab Cardiovasc Dis. 2017;27:571-580 pubmed publisher
    ..043) were independent predictors of IMT. Overall, we suggest that in obese subjects altered adipokine levels play a key role in common carotid atherosclerosis both directly and through haemostatic parameters. ..
  46. Ferrian S, Manca C, Lubbe S, Conradie F, Ismail N, Kaplan G, et al. A combination of baseline plasma immune markers can predict therapeutic response in multidrug resistant tuberculosis. PLoS ONE. 2017;12:e0176660 pubmed publisher
    ..Plasma levels of specific chemokines and inflammatory markers measured before MDR-TB treatment are candidate predictive markers of delayed SCC. These findings require validation in a larger study. ..
  47. Tefferi A, Mudireddy M, Gangat N, Hanson C, Ketterling R, Pardanani A, et al. Risk factors and a prognostic model for postsplenectomy survival in myelofibrosis. Am J Hematol. 2017;92:1187-1192 pubmed publisher
    ..Leukemia-free survival was predicted by very high risk karyotype. The observations from the current study might help identify appropriate candidates for splenectomy in MF. ..
  48. Nectow A, Moya M, Ekstrand M, Mousa A, McGuire K, Sferrazza C, et al. Rapid Molecular Profiling of Defined Cell Types Using Viral TRAP. Cell Rep. 2017;19:655-667 pubmed publisher
    ..Altogether, these results establish the broad applicability of the vTRAP strategy for the molecular dissection of any CNS or peripheral cell type that can be engineered to express Cre. ..
  49. Manhardt C, Punch P, Dougher C, Lau J. Extrinsic sialylation is dynamically regulated by systemic triggers in vivo. J Biol Chem. 2017;292:13514-13520 pubmed publisher
    ..Together, these observations form an emerging picture of glycans biosynthesized by the canonical cell-autonomous glycosylation pathway, but subjected to remodeling by extracellular glycan-modifying enzymes. ..
  50. Grill J, Apostolova L, Bullain S, Burns J, Cox C, Dick M, et al. Communicating mild cognitive impairment diagnoses with and without amyloid imaging. Alzheimers Res Ther. 2017;9:35 pubmed publisher
    ..Amyloid imaging may be a tool to aid clinicians. Careful management of patient expectations and communication of scan results will be critical to the appropriate use of amyloid imaging information. ..
  51. Schick S, Blount B, Jacob P, Saliba N, Bernert J, El Hellani A, et al. Biomarkers of exposure to new and emerging tobacco delivery products. Am J Physiol Lung Cell Mol Physiol. 2017;313:L425-L452 pubmed publisher
  52. Barlow Anacker A, Bochkov Y, Gern J, Seroogy C. Neonatal immune response to rhinovirus A16 has diminished dendritic cell function and increased B cell activation. PLoS ONE. 2017;12:e0180664 pubmed publisher
    ..In this study, we undertook a comparative analysis of neonatal and adult blood immune cell responses after in vitro incubation with infectious RV-A16 for 6 and 24 hours...
  53. Wirth J, Woodruff B, Engle Stone R, Namaste S, Temple V, Petry N, et al. Predictors of anemia in women of reproductive age: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project. Am J Clin Nutr. 2017;106:416S-427S pubmed publisher
    ..Anemia-reduction programs for WRA can be improved by considering the underlying infection burden of the population and by assessing the overlap of micronutrient deficiencies and anemia. ..
  54. Cara Fuentes G, Segarra A, Silva Sanchez C, Wang H, Lanaspa M, Johnson R, et al. Angiopoietin-like-4 and minimal change disease. PLoS ONE. 2017;12:e0176198 pubmed publisher
    ..Neither serum nor urine Angptl4 appear to be good biomarkers in MCD. Elevated urinary Angptl4 n glomerular disease appears to reflect the degree of proteinuria rather than any specific disease. ..
  55. Dente C, Bradley M, Schobel S, Gaucher B, Buchman T, Kirk A, et al. Towards precision medicine: Accurate predictive modeling of infectious complications in combat casualties. J Trauma Acute Care Surg. 2017;83:609-616 pubmed publisher
    ..This and similar tools will allow for increasing precision in the management of critically ill and injured patients. Prognostic, level III. ..
  56. Oskouie S, Prenner S, Shah S, Sauer A. Differences in Repolarization Heterogeneity Among Heart Failure With Preserved Ejection Fraction Phenotypic Subgroups. Am J Cardiol. 2017;120:601-606 pubmed publisher
    ..In conclusion, repolarization heterogeneity is a marker of a specific subset of HFpEF patients identified using unsupervised machine learning analysis and therefore may be a key pathophysiologic marker in this subset of HFpEF patients. ..
  57. Groner J, Huang H, Joshi M, Eastman N, Nicholson L, Bauer J. Secondhand Smoke Exposure and Preclinical Markers of Cardiovascular Risk in Toddlers. J Pediatr. 2017;189:155-161 pubmed publisher
    ..Further studies to define mechanisms and strategies to prevent and mitigate these risks early in life are warranted. ..
  58. Madder R, VanOosterhout S, Klungle D, Mulder A, Elmore M, Decker J, et al. Multimodality Intracoronary Imaging With Near-Infrared Spectroscopy and Intravascular Ultrasound in Asymptomatic Individuals With High Calcium Scores. Circ Cardiovasc Imaging. 2017;10: pubmed publisher
    ..This observation may have implications on coronary risk among individuals with a high CACS considering that it is coronary LRP, rather than calcification, that underlies the majority of acute coronary events. ..
  59. Harjes L, Parker V, Dembek K, Young G, Giovaninni L, Kogika M, et al. Fibroblast Growth Factor-23 Concentration in Dogs with Chronic Kidney Disease. J Vet Intern Med. 2017;31:784-790 pubmed publisher
    ..Plasma FGF-23 concentrations increase in dogs with CKD as disease progresses. Plasma FGF-23 concentrations appear to be useful for further study of the pathophysiology of CKD-MBD in dogs. ..
  60. Robertson D, Watkins P, Reily M. Metabolomics in toxicology: preclinical and clinical applications. Toxicol Sci. 2011;120 Suppl 1:S146-70 pubmed publisher
  61. Nano J, Ghanbari M, Wang W, de Vries P, Dhana K, Muka T, et al. Epigenome-Wide Association Study Identifies Methylation Sites Associated With Liver Enzymes and Hepatic Steatosis. Gastroenterology. 2017;153:1096-1106.e2 pubmed publisher
    ..Our results provide new insights into epigenetic mechanisms associated with markers of liver function and hepatic steatosis, laying the groundwork for future diagnostic and therapeutic applications. ..
  62. Desai P, Helkin A, Odugbesi A, Stein J, Bruch D, Lawler J, et al. Fluvastatin inhibits intimal hyperplasia in wild-type but not Thbs1-null mice. J Surg Res. 2017;210:1-7 pubmed publisher
    ..Because fluvastatin had no effect on IH in Thbs1-/-, the data suggest that the statin effect on IH may be largely TSP-1 dependent. Both statins and the presence of TSP-1 affect TSP-1 and TSP-2 plasma levels. ..
  63. Foster M, Levey A, Inker L, Shafi T, Fan L, Gudnason V, et al. Non-GFR Determinants of Low-Molecular-Weight Serum Protein Filtration Markers in the Elderly: AGES-Kidney and MESA-Kidney. Am J Kidney Dis. 2017;70:406-414 pubmed publisher
    ..Both cystatin C and B2M levels may be affected by inflammation. These findings are important for the development and use of GFR estimating equations based on low-molecular-weight serum proteins throughout the range in GFRs. ..
  64. Stadem P, Hilgers M, Bengo D, Cusick S, Ndidde S, Slusher T, et al. Markers of oxidative stress in umbilical cord blood from G6PD deficient African newborns. PLoS ONE. 2017;12:e0172980 pubmed publisher
    ..These data suggest increased baseline oxidative stress and an elevated antioxidant response in umbilical cord blood of patients with G6PD deficiency. ..
  65. Ucar D, Márquez E, Chung C, Marches R, Rossi R, Uyar A, et al. The chromatin accessibility signature of human immune aging stems from CD8+ T cells. J Exp Med. 2017;214:3123-3144 pubmed publisher
    ..Thus, our study provides a unique and comprehensive approach to identifying candidate biomarkers and provides mechanistic insights into aging-associated immunodeficiency. ..
  66. Esplin M, Elovitz M, Iams J, Parker C, Wapner R, Grobman W, et al. Predictive Accuracy of Serial Transvaginal Cervical Lengths and Quantitative Vaginal Fetal Fibronectin Levels for Spontaneous Preterm Birth Among Nulliparous Women. JAMA. 2017;317:1047-1056 pubmed publisher
    ..These findings do not support routine use of these tests in such women. ..
  67. Naglich A, Nelson L, Iuppa C, Diefenderfer L, Elliott E, Sommi R. Plasma Insulin Level Correlation to Metabolic Parameter Shifts in Hospitalized Psychiatric Patients. Prim Care Companion CNS Disord. 2017;19: pubmed publisher
    ..The results do not support routine use of plasma insulin as a predictor for shifts in metabolic parameters in patients receiving antipsychotic medications. ..
  68. Wysocki J, Goodling A, Burgaya M, Whitlock K, Ruzinski J, Batlle D, et al. Urine RAS components in mice and people with type 1 diabetes and chronic kidney disease. Am J Physiol Renal Physiol. 2017;313:F487-F494 pubmed publisher
    ..ACEI use was associated with a specific reduction in urine ACE activity, not ACE protein concentration, suggesting that it may be a marker of exposure to this widely-used therapy. ..
  69. Kurihara C, Tanaka T, Yamanouchi D. Hyperglycemia attenuates receptor activator of NF-κB ligand-induced macrophage activation by suppressing insulin signaling. J Surg Res. 2017;214:168-175 pubmed publisher
    ..These data suggest that HG suppressed macrophage activation, through attenuation of glucose uptake via the suppression of the membrane translocation of Glut1 and insulin signaling. ..
  70. Adhami N, Chen Y, Martins Green M. Biomarkers of disease can be detected in mice as early as 4 weeks after initiation of exposure to third-hand smoke levels equivalent to those found in homes of smokers. Clin Sci (Lond). 2017;131:2409-2426 pubmed publisher
  71. Sethi S, Zand L, De Vriese A, Specks U, Vrana J, Kanwar S, et al. Complement activation in pauci-immune necrotizing and crescentic glomerulonephritis: results of a proteomic analysis. Nephrol Dial Transplant. 2017;32:i139-i145 pubmed publisher
  72. Ren J, Zhao Y, Wang J, Ren X, Xu Y, Tang W, et al. PepsinA as a Marker of Laryngopharyngeal Reflux Detected in Chronic Rhinosinusitis Patients. Otolaryngol Head Neck Surg. 2017;156:893-900 pubmed publisher
    ..Conclusion The results of this study provided evidence of an association between LPR and CRS, although no correlation was found to exist between LPR and mucin genes in CRS patients. ..
  73. Walter B, Mageswaran P, Mo X, Boulter D, Mashaly H, Nguyen X, et al. MR Elastography-derived Stiffness: A Biomarker for Intervertebral Disc Degeneration. Radiology. 2017;285:167-175 pubmed publisher
    ..These results suggest that MR elastography-derived shear stiffness may provide an objective biomarker of the IVD degeneration process. © RSNA, 2017 Online supplemental material is available for this article. ..
  74. Chung S, Weber F, Zhong P, Tan C, Nguyen T, BEIER K, et al. Identification of preoptic sleep neurons using retrograde labelling and gene profiling. Nature. 2017;545:477-481 pubmed publisher
    ..Together, these findings provide easy genetic access to sleep-promoting preoptic area neurons and a valuable entry point for dissecting the sleep control circuit. ..
  75. Weintraub W, Luscher T, Pocock S. The perils of surrogate endpoints. Eur Heart J. 2015;36:2212-8 pubmed publisher
  76. Stolper D, Love G, Bates S, Lyons T, Young E, Sessions A, et al. Paleoecology and paleoceanography of the Athel silicilyte, Ediacaran-Cambrian boundary, Sultanate of Oman. Geobiology. 2017;15:401-426 pubmed publisher
    ..We propose that the silicilyte may represent a type of environment that existed elsewhere during the Neoproterozoic. These environments may have represented an important locus for silica removal from the oceans. ..
  77. McCarthy C, van Kimmenade R, Gaggin H, Simon M, Ibrahim N, Gandhi P, et al. Usefulness of Multiple Biomarkers for Predicting Incident Major Adverse Cardiac Events in Patients Who Underwent Diagnostic Coronary Angiography (from the Catheter Sampled Blood Archive in Cardiovascular Diseases [CASABLANCA] Study). Am J Cardiol. 2017;120:25-32 pubmed publisher
    ..001); such risk extended to at least to 4 years. In conclusion, in a cohort of patients who underwent coronary angiography, we describe a novel multiple biomarker score for incident MACE within 1 year (NCT00842868). ..
  78. Mei Z, Namaste S, Serdula M, Suchdev P, Rohner F, Flores Ayala R, et al. Adjusting total body iron for inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project. Am J Clin Nutr. 2017;106:383S-389S pubmed publisher
    ..b>Conclusion: The prevalence of low TBI is underestimated if it is not adjusted by inflammation, particularly in children living in areas with a high prevalence of inflammation. ..
  79. Saber H, Yakoob M, Shi P, Longstreth W, Lemaitre R, Siscovick D, et al. Omega-3 Fatty Acids and Incident Ischemic Stroke and Its Atherothrombotic and Cardioembolic Subtypes in 3 US Cohorts. Stroke. 2017;48:2678-2685 pubmed publisher
    ..These novel findings suggest differential pathways of benefit for DHA, DPA, and eicosapentaenoic acid. ..
  80. Gallentine W, Shinnar S, Hesdorffer D, Epstein L, Nordli D, Lewis D, et al. Plasma cytokines associated with febrile status epilepticus in children: A potential biomarker for acute hippocampal injury. Epilepsia. 2017;58:1102-1111 pubmed publisher
    ..If replicated in another study, the IL-1RA/IL-6 ratio could represent a serologic biomarker that offers rapid identification of patients at risk for ultimately developing mesial temporal lobe epilepsy (MTLE). ..
  81. van Capelleveen J, Bernelot Moens S, Yang X, Kastelein J, Wareham N, Zwinderman A, et al. Apolipoprotein C-III Levels and Incident Coronary Artery Disease Risk: The EPIC-Norfolk Prospective Population Study. Arterioscler Thromb Vasc Biol. 2017;37:1206-1212 pubmed publisher
    ..ApoC-III levels are significantly associated with incident CAD risk. Elevated levels of remnant lipoproteins, small dense low-density lipoprotein, and low-grade inflammation may explain this association. ..
  82. Maillard P, Mitchell G, Himali J, Beiser A, Fletcher E, Tsao C, et al. Aortic Stiffness, Increased White Matter Free Water, and Altered Microstructural Integrity: A Continuum of Injury. Stroke. 2017;48:1567-1573 pubmed publisher
  83. Cárdenas González M, Srivastava A, Pavkovic M, Bijol V, Rennke H, Stillman I, et al. Identification, Confirmation, and Replication of Novel Urinary MicroRNA Biomarkers in Lupus Nephritis and Diabetic Nephropathy. Clin Chem. 2017;63:1515-1526 pubmed publisher
    ..We have identified novel miRNAs that correlate with histopathological lesions and functional markers of kidney damage to facilitate sensitive, specific, and noninvasive detection of diabetic nephropathy and lupus nephritis. ..
  84. Nixon R, Cataldo A, Paskevich P, Hamilton D, Wheelock T, Kanaley Andrews L. The lysosomal system in neurons. Involvement at multiple stages of Alzheimer's disease pathogenesis. Ann N Y Acad Sci. 1992;674:65-88 pubmed
  85. Relkin N, Thomas R, Rissman R, Brewer J, Rafii M, van Dyck C, et al. A phase 3 trial of IV immunoglobulin for Alzheimer disease. Neurology. 2017;88:1768-1775 pubmed publisher
    ..NCT00818662. This study provides Class II evidence that IVIg infusions performed every 2 weeks do not improve cognition or function at 18 months in patients with mild to moderate AD. ..
  86. Zipursky R, Press M, Srikanthan P, Gornbein J, McClelland R, Watson K, et al. Relation of Stress Hormones (Urinary Catecholamines/Cortisol) to Coronary Artery Calcium in Men Versus Women (from the Multi-Ethnic Study of Atherosclerosis [MESA]). Am J Cardiol. 2017;119:1963-1971 pubmed publisher
    ..These simple urinary biomarkers contribute to our understanding of the role of stress in the pathogenesis of CAD and may be incorporated into future strategies to prevent and treat CAD. ..
  87. Shaikh I, Rishi M, Youssef M, Selvaraju V, Thirunavukkarasu M, Ukani G, et al. Overexpression of Thioredoxin1 enhances functional recovery in a mouse model of hind limb ischemia. J Surg Res. 2017;216:158-168 pubmed publisher
    ..These results suggest that Trx1 is a potential target for clinical trials and drug therapy for the treatment of PVD. ..
  88. Todorov I, Werness B, Wang H, Buddharaju L, Todorova P, Slocum H, et al. HsMCM2/BM28: a novel proliferation marker for human tumors and normal tissues. Lab Invest. 1998;78:73-8 pubmed
  89. Crosby J, Kaminski W, Schatteman G, Martin P, Raines E, Seifert R, et al. Endothelial cells of hematopoietic origin make a significant contribution to adult blood vessel formation. Circ Res. 2000;87:728-30 pubmed
  90. Unalp Arida A, Ruhl C, Choung R, Brantner T, Murray J. Lower Prevalence of Celiac Disease and Gluten-Related Disorders in Persons Living in Southern vs Northern Latitudes of the United States. Gastroenterology. 2017;152:1922-1932.e2 pubmed publisher
    ..Mean levels of vitamin B-12 and folate are lower in individuals with undiagnosed celiac disease, and levels of hemoglobin are lower in participants with a diagnosis of celiac disease, compared with individuals without celiac disease. ..
  91. Kenney M, Waters R, Rieder E, Pega J, Perez Filguera M, Golde W. Enhanced sensitivity in detection of antiviral antibody responses using biotinylation of foot-and-mouth disease virus (FMDV) capsids. J Immunol Methods. 2017;450:1-9 pubmed publisher
  92. Mikacenic C, Price B, Harju Baker S, O Mahony D, Robinson Cohen C, Radella F, et al. A Two-Biomarker Model Predicts Mortality in the Critically Ill with Sepsis. Am J Respir Crit Care Med. 2017;196:1004-1011 pubmed publisher
    ..Improving the prospective identification of patients with systemic inflammatory response syndrome (SIRS) and sepsis at low risk for organ dysfunction and death is a major clinical challenge...