Experts and Doctors on biological transport in Japan


Locale: Japan
Topic: biological transport

Top Publications

  1. Sugimoto H, Sugahara M, FOLSCH H, Koide Y, Nakatsu F, Tanaka N, et al. Differential recognition of tyrosine-based basolateral signals by AP-1B subunit mu1B in polarized epithelial cells. Mol Biol Cell. 2002;13:2374-82 pubmed
    ..Our results suggest that mu1B interacts with different classes of basolateral targeting signals in distinct ways. ..
  2. Wada S, Tanabe K, Yamazaki A, Niimi M, Uehara Y, Niimi K, et al. Phosphorylation of candida glabrata ATP-binding cassette transporter Cdr1p regulates drug efflux activity and ATPase stability. J Biol Chem. 2005;280:94-103 pubmed
    ..Nucleotide binding domain 1 of Cdr1p is a sensor of important physiological stimuli. ..
  3. Kimura O, Endo T, Hotta Y, Sakata M. Effects of P-glycoprotein inhibitors on transepithelial transport of cadmium in cultured renal epithelial cells, LLC-PK1 and LLC-GA5-COL 150. Toxicology. 2005;208:123-32 pubmed
    ..These results suggest that Cd is extruded from the apical membrane of LLC-PK(1) and LLC-GA5-COL 150 cells, probably depending on the level of P-gp expression. ..
  4. Sugi T, Morikawa K, Jingami H. [Metabotropic glutamate receptor trafficking mechanism--autoinhibitory role of a scaffold protein tamalin]. Seikagaku. 2008;80:416-20 pubmed
  5. Morita M, Nakamura M. Dynamic behavior of plastids related to environmental response. Curr Opin Plant Biol. 2012;15:722-8 pubmed publisher
  6. Nishiyama K, Mizushima S, Tokuda H. The carboxyl-terminal region of SecE interacts with SecY and is functional in the reconstitution of protein translocation activity in Escherichia coli. J Biol Chem. 1992;267:7170-6 pubmed
    ..The N-terminal region of SecE (SecE-N) also suppressed in vivo the defect caused by the secEcs mutation. SecE-N was, however, inactive in the overproduction of SecY. A possible oligomeric structure of SecE is discussed. ..
  7. Tajima Y, Okamura N. The enhancing effects of anion channel blockers on sperm activation by bicarbonate. Biochim Biophys Acta. 1990;1034:326-32 pubmed
  8. Matsuda A, Kosugi S. A homozygous missense mutation of the sodium/iodide symporter gene causing iodide transport defect. J Clin Endocrinol Metab. 1997;82:3966-71 pubmed
    ..Northern analysis of thyroid ribonucleic acid revealed that NIS messenger ribonucleic acid level was markedly increased (> 100-fold) compared with that in the normal thyroid, suggesting possible compensation by overexpression...
  9. Nishijyo T, Park S, Lu C, Itoh Y, Abdelal A. Molecular characterization and regulation of an operon encoding a system for transport of arginine and ornithine and the ArgR regulatory protein in Pseudomonas aeruginosa. J Bacteriol. 1998;180:5559-66 pubmed
    ..aeruginosa. Sequence alignment confirms the architecture and the consensus sequence of the ArgR binding sites, as was previously reported. ..

More Information

Publications230 found, 100 shown here

  1. Morio T, Hanissian S, Bacharier L, Teraoka H, Nonoyama S, Seki M, et al. Ku in the cytoplasm associates with CD40 in human B cells and translocates into the nucleus following incubation with IL-4 and anti-CD40 mAb. Immunity. 1999;11:339-48 pubmed
    ..These findings indicate that Ku is involved in the CD40 signal transduction pathway and may play an important role in the CD40-mediated events. ..
  2. Itoh T. [Pharmacokinetic study of cancer chemotherapy]. Yakugaku Zasshi. 2006;126:723-35 pubmed
    ..Baicalin inhibited the uptake of SN-38. A specific transport system mediates the uptake of SN-38 across the apical membrane in Caco-2 cells. Inhibition of this transporter would be a useful means for reducing late-onset diarrhea. ..
  3. Kawano Y, Nishiumi S, Tanaka S, Nobutani K, Miki A, Yano Y, et al. Activation of the aryl hydrocarbon receptor induces hepatic steatosis via the upregulation of fatty acid transport. Arch Biochem Biophys. 2010;504:221-7 pubmed publisher
    ..Taking together, AHR activation induces hepatic microvesicular steatosis by increasing the expression level of FAT...
  4. Wakuda H, Nejime N, Tada Y, Kagota S, Fahmi O, Umegaki K, et al. A novel method using confocal laser scanning microscopy for sensitive measurement of P-glycoprotein-mediated transport activity in Caco-2 cells. J Pharm Pharmacol. 2011;63:1015-21 pubmed publisher
    ..It will be a valuable screening tool for studying both the inhibition and induction of P-glycoprotein activity. ..
  5. Serag M, Kaji N, Venturelli E, Okamoto Y, Terasaka K, Tokeshi M, et al. Functional platform for controlled subcellular distribution of carbon nanotubes. ACS Nano. 2011;5:9264-70 pubmed publisher
  6. Takagi K. [Effects of prostaglandin F2 alpha on steroidogenesis of the PMSG-hCG primed rat ovary in luteolysis]. Nihon Naibunpi Gakkai Zasshi. 1988;64:1024-37 pubmed
    ..Both plasma 20 alpha OHP4 and 20 alpha HSD in Sup increased with PGF2 alpha treatment. However, CX suppressed both of them.(ABSTRACT TRUNCATED AT 400 WORDS) ..
  7. Okada Y, Yamazaki H, Sekine Aizawa Y, Hirokawa N. The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors. Cell. 1995;81:769-80 pubmed
    ..Thus, we suggest that the membrane proteins are sorted into different classes of transport organelles in the cell body and are transported by their specific motor proteins through the axon. ..
  8. Moritani C, Ohhashi T, Satoh S, Oesterhelt D, Ikeda M. Purification and characterization of a membrane-bound ATPase from Acetabularia cliftonii that corresponds to a Cl(-)-translocating ATPase in Acetabularia acetabulum. Biosci Biotechnol Biochem. 1994;58:2087-9 pubmed
    ..Immunological characterization of both subunits showed significant similarity to the F type of ATPase. Cl(-)-transport activity was observed by reconstitution studies into liposomes...
  9. Honda K, Nakamura K, Nishiguchi M, Yamane K. Cloning and characterization of a Bacillus subtilis gene encoding a homolog of the 54-kilodalton subunit of mammalian signal recognition particle and Escherichia coli Ffh. J Bacteriol. 1993;175:4885-94 pubmed
    ..The depletion of ffh in B. subtilis led to growth arrest and drastic morphological changes. Furthermore, the translocation of beta-lactamase and alpha-amylase under the depleted condition was also defective. ..
  10. Kanai T, Takeshita S, Atomi H, Umemura K, Ueda M, Tanaka A. A regulatory factor, Fil1p, involved in derepression of the isocitrate lyase gene in Saccharomyces cerevisiae--a possible mitochondrial protein necessary for protein synthesis in mitochondria. Eur J Biochem. 1998;256:212-20 pubmed
  11. Ito K, Okamoto I, Araki N, Kawano Y, Nakao M, Fujiyama S, et al. Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of beta-catenin from cell-cell contacts. Oncogene. 1999;18:7080-90 pubmed
  12. Taguchi T, Kishikawa H, Motoshima H, Sakai K, Nishiyama T, Yoshizato K, et al. Involvement of bradykinin in acute exercise-induced increase of glucose uptake and GLUT-4 translocation in skeletal muscle: studies in normal and diabetic humans and rats. Metabolism. 2000;49:920-30 pubmed
  13. Kondo M, Okabe S, Sumino R, Okado H. A high GluR1 : GluR2 expression ratio is correlated with expression of Ca2+-binding proteins in rat forebrain neurons. Eur J Neurosci. 2000;12:2812-22 pubmed
    ..These results suggest that the expression of calbindin-D28k is related to the expression of Ca2+-permeable AMPA receptors. ..
  14. Khamdang S, Takeda M, Babu E, Noshiro R, Onozato M, Tojo A, et al. Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics. Eur J Pharmacol. 2003;465:1-7 pubmed
    ..The interaction of human-OAT2 with cephalosporins was the weakest among the basolateral human-OATs tested. In addition, it is suggested that human-OATs mediate cephaloridine-induced nephrotoxicity. ..
  15. Mizuarai S, Aozasa N, Kotani H. Single nucleotide polymorphisms result in impaired membrane localization and reduced atpase activity in multidrug transporter ABCG2. Int J Cancer. 2004;109:238-46 pubmed
  16. Ezaki B, Nakakihara E. Possible involvement of GDI1 protein, a GDP dissociation inhibitor related to vesicle transport, in an amelioration of zinc toxicity in Saccharomyces cerevisiae. Yeast. 2012;29:17-24 pubmed publisher
    ..Collectively, the results suggest that the GDI1protein is involved in Zn efflux via small vesicle trafficking and contributes to the control of cytoplasmic Zn content, allowing yeast to survive in the presence of toxic Zn. ..
  17. Tsuchiya A, Kanno T, Saito M, Miyoshi Y, Gotoh A, Nakano T, et al. Intracellularly transported adenosine induces apoptosis in [corrected] MCF-7 human breast cancer cells by accumulating AMID in the nucleus. Cancer Lett. 2012;321:65-72 pubmed publisher
    ..The results of the present study indicate that intracellularly transported adenosine induces MCF-7 cell apoptosis by accumulating AMID in the nucleus in a caspase-independent manner. ..
  18. Togawa N, Miyaji T, Izawa S, Omote H, Moriyama Y. A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter. Am J Physiol Cell Physiol. 2012;302:C1652-60 pubmed publisher
    ..Since SLC17A1 protein (NPT1) and SLC17A3 protein (NPT4) are responsible for renal urate extrusion, our results reveal the possible involvement of a NPT homologue in urate extrusion from the intestinal duct. ..
  19. Baba T, Jacq A, Brickman E, Beckwith J, Taura T, Ueguchi C, et al. Characterization of cold-sensitive secY mutants of Escherichia coli. J Bacteriol. 1990;172:7005-10 pubmed
  20. Kiyosue T, Abe H, Yamaguchi Shinozaki K, Shinozaki K. ERD6, a cDNA clone for an early dehydration-induced gene of Arabidopsis, encodes a putative sugar transporter. Biochim Biophys Acta. 1998;1370:187-91 pubmed
    ..Genomic Southern blots indicate that the ERD6 gene is a member of a multigene family in the Arabidopsis genome. The expression of the ERD6 gene was induced not only by dehydration but also by cold treatment. ..
  21. Matsuda K, Yuasa H, Watanabe J. Dose dependency in the gastrointestinal absorption of cefatrizine: correlation between in vivo and in situ. Biol Pharm Bull. 1998;21:604-9 pubmed
  22. Shiraishi E, Inouhe M, Joho M, Tohoyama H. The cadmium-resistant gene, CAD2, which is a mutated putative copper-transporter gene (PCA1), controls the intracellular cadmium-level in the yeast S. cerevisiae. Curr Genet. 2000;37:79-86 pubmed
    ..From these results, we conclude that the Cad2 protein controls the intracellular cadmium level through an enhanced cadmium efflux system. ..
  23. Tamai A, Meshi T. Cell-to-cell movement of Potato virus X: the role of p12 and p8 encoded by the second and third open reading frames of the triple gene block. Mol Plant Microbe Interact. 2001;14:1158-67 pubmed
    ..Considering the likelihood that p12 and p8 are membrane proteins, it is suggested that intercellular as well as intracellular movement of PVX involves a membrane-mediated process...
  24. Adachi Y, Suzuki H, Sugiyama Y. Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001;18:1660-8 pubmed
    ..The extent of ATP-hydrolysis in vitro may also be a useful parameter for in vivo prediction, particularly for eliminating P-gp substrates in high-throughput screening procedures. ..
  25. Yui N, Ooya T, Kawashima T, Saito Y, Tamai I, Sai Y, et al. Inhibitory effect of supramolecular polyrotaxane-dipeptide conjugates on digested peptide uptake via intestinal human peptide transporter. Bioconjug Chem. 2002;13:582-7 pubmed
    ..Therefore, our data clearly suggests that supramolecular structure in the polyrotaxane conjugates contributes considerably to the inhibitory effect via multivalent binding of Val-Lys groups with hPEPT1. ..
  26. Sato H, Nomura S, Maebara K, Sato K, Tamba M, Bannai S. Transcriptional control of cystine/glutamate transporter gene by amino acid deprivation. Biochem Biophys Res Commun. 2004;325:109-16 pubmed
    ..These results demonstrate that xCT is a new member of the proteins whose transcriptional control by the amino acid deprivation is mediated by AARE. ..
  27. Funahashi T, Tanabe T, Shiuchi K, Nakao H, Yamamoto S. Identification and characterization of genes required for utilization of desferri-ferrichrome and aerobactin in Vibrio parahaemolyticus. Biol Pharm Bull. 2009;32:359-65 pubmed
    ..Moreover, it was found that the fhuCDB genes are also required for transport of ferric aerobactin which restores growth of this species under iron-limiting conditions...
  28. Kobayashi J, Kinoshita K, Mizukawa K, Sakurai T, Imaizumi Y, Takada H, et al. Dietary uptake kinetics of polychlorinated biphenyls from sediment-contaminated sandworms in a marine benthic fish (Pseudopleuronectes yokohamae). Chemosphere. 2011;82:745-50 pubmed publisher
    ..The growth-corrected half-lives of 26 PCB congeners in the muscle of fish ranged from 20 to 107d...
  29. Sekine Y, Okada Y, Noda Y, Kondo S, Aizawa H, Takemura R, et al. A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally. J Cell Biol. 1994;127:187-201 pubmed
    ..Hence we conclude that KIF4 is a novel microtubule-associated anterograde motor protein for membranous organelles, the expression of which is regulated developmentally. ..
  30. Hara K, Yonezawa K, Sakaue H, Ando A, Kotani K, Kitamura T, et al. 1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells. Proc Natl Acad Sci U S A. 1994;91:7415-9 pubmed
    ..These results suggest that PI 3-kinase is required for glucose transport in insulin signaling in CHO cells. ..
  31. Sasaki E, Ohta Y, Shinohara R, Ishiguro I. Contribution of serum albumin to the transport of orally administered L-tryptophan into liver of rats with L-tryptophan depletion. Amino Acids. 1999;16:29-39 pubmed
    ..These results suggest that variations in serum albumin levels could affect the transport of orally administered Trp into the liver of rats with Trp depletion. ..
  32. Oka M, Miyamoto K, Okada K, Ueda J. Auxin polar transport and flower formation in Arabidopsis thaliana transformed with indoleacetamide hydrolase (iaaH) gene. Plant Cell Physiol. 1999;40:231-7 pubmed
    ..These results suggest that the construction of the system of auxin polar transport and its normal activities are essential for the differentiation and the formation of floral meristem in the early growth stage of Arabidopsis thaliana. ..
  33. Kosugi S, Bhayana S, Dean H. A novel mutation in the sodium/iodide symporter gene in the largest family with iodide transport defect. J Clin Endocrinol Metab. 1999;84:3248-53 pubmed
  34. Komatani H, Kotani H, Hara Y, Nakagawa R, Matsumoto M, Arakawa H, et al. Identification of breast cancer resistant protein/mitoxantrone resistance/placenta-specific, ATP-binding cassette transporter as a transporter of NB-506 and J-107088, topoisomerase I inhibitors with an indolocarbazole structure. Cancer Res. 2001;61:2827-32 pubmed
    ..However, the transfectants were not resistant to mitoxantrone or topotecan, the drugs previously thought to be the substrates of BCRP. Thus, our study presents a novel mechanism of drug resistance mediated by BCRP...
  35. Matsumura T, Moriyasu F, Toda Y, Kishi K, Chiba T, Tabat Y. Ultrasound exposure enhances the biological action of interferon in the liver. J Drug Target. 2002;10:205-9 pubmed
  36. Murakami S, Nakashima R, Yamashita E, Yamaguchi A. Crystal structure of bacterial multidrug efflux transporter AcrB. Nature. 2002;419:587-93 pubmed
  37. Iwakiri K, Ghazizadeh M, Jin E, Fujiwara M, Takemura T, Takezaki S, et al. Human airway trypsin-like protease induces PAR-2-mediated IL-8 release in psoriasis vulgaris. J Invest Dermatol. 2004;122:937-44 pubmed
    ..Inhibition of PAR-2 resulted in a decreased HAT-induced IL-8 release. Thus, HAT might promote PAR-2-mediated IL-8 production to accumulate inflammatory cells in the epidermal layer of psoriasis. ..
  38. Otagiri M. [Study on binding of drug to serum protein]. Yakugaku Zasshi. 2009;129:413-25 pubmed
    ..Finally, cases in which protein binding displacement can be applied to medical fields will also be introduced. ..
  39. Ogasawara K, Terada T, Katsura T, Hatano E, Ikai I, Yamaoka Y, et al. Hepatitis C virus-related cirrhosis is a major determinant of the expression levels of hepatic drug transporters. Drug Metab Pharmacokinet. 2010;25:190-9 pubmed
    ..These findings indicate that HCV-related cirrhosis is a crucial factor affecting the expression of hepatic drug transporters, especially MRP4. ..
  40. Takumida M, Kakigi A, Egami N, Nishioka R, Anniko M. Localization of aquaporins 1, 2, and 3 and vasopressin type 2 receptor in the mouse inner ear. Acta Otolaryngol. 2012;132:807-13 pubmed publisher
    ..e. stria vascularis, inner and outer hair cells, spiral ganglion cells, vestibular sensory and ganglion cells, vestibular dark and transitional cells, and the endolymphatic sac. ..
  41. Aoki Y, Manzano R, Lee Y, Dafinca R, Aoki M, Douglas A, et al. C9orf72 and RAB7L1 regulate vesicle trafficking in amyotrophic lateral sclerosis and frontotemporal dementia. Brain. 2017;140:887-897 pubmed publisher
    ..In conclusion, we have identified a novel mechanism for C9ALS/FTD pathogenesis highlighting the molecular regulation of intracellular and extracellular vesicle trafficking as an important pathway in C9ALS/FTD pathogenesis. ..
  42. Kamisako T, Ogawa H. Alteration of the expression of adenosine triphosphate-binding cassette transporters associated with bile acid and cholesterol transport in the rat liver and intestine during cholestasis. J Gastroenterol Hepatol. 2005;20:1429-34 pubmed
    ..The purpose of the present study was to evaluate intestinal and hepatic adenosine triphosphate-binding cassette transporter expressions during cholestasis...
  43. Yamasaki K, Motomura Y, Yagi Y, Nomura H, Kikuchi S, Nakai M, et al. Chloroplast envelope localization of EDS5, an essential factor for salicylic acid biosynthesis in Arabidopsis thaliana. Plant Signal Behav. 2013;8:e23603 pubmed publisher
    ..In addition, we found that EDS5 is preferentially expressed in epidermal cells. These findings suggest that EDS5 is responsible for transport of SA from chloroplasts to the cytoplasm in epidermal cells. ..
  44. Ohyama T, Imaizumi R, Igarashi K, Kobayashi H. Escherichia coli is able to grow with negligible sodium ion extrusion activity at alkaline pH. J Bacteriol. 1992;174:7743-9 pubmed
  45. Suzuki T, Hirai H, Murakami T, Yoshida M. Tax protein of HTLV-1 destabilizes the complexes of NF-kappa B and I kappa B-alpha and induces nuclear translocation of NF-kappa B for transcriptional activation. Oncogene. 1995;10:1199-207 pubmed
    ..These Tax effects counteract the negative feedback control of NF-kappa B by I kappa B-alpha and contribute to constitutive activation of NF-kappa B in Tax-transfected and HTLV-1-infected cells. ..
  46. Okuda M, Saito H, Urakami Y, Takano M, Inui K. cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2. Biochem Biophys Res Commun. 1996;224:500-7 pubmed
    ..These findings suggest that OCT2 is responsible for the transport of cationic drugs in the kidney...
  47. Fujita H, Syono K. Genetic analysis of the effects of polar auxin transport inhibitors on root growth in Arabidopsis thaliana. Plant Cell Physiol. 1996;37:1094-101 pubmed
    ..thaliana, and (4) in contrast to NPA, TIBA itself has a weak auxin-like inhibitory effect. ..
  48. Kumano M, Tamakoshi A, Yamane K. A 32 kb nucleotide sequence from the region of the lincomycin-resistance gene (22 degrees-25 degrees) of the Bacillus subtilis chromosome and identification of the site of the lin-2 mutation. Microbiology. 1997;143 ( Pt 8):2775-82 pubmed
    ..LmrB is a homologue of proteins involved in drug-export systems and seems likely to be the protein responsible for resistance to lincomycin. ..
  49. Matsuoka T, Nishizaki T, Kisby G. Na+-dependent and phlorizin-inhibitable transport of glucose and cycasin in brain endothelial cells. J Neurochem. 1998;70:772-7 pubmed
    ..These results suggest that cycasin is selectively transported across brain endothelial cells, possibly across the BBB by a Na+/energy-dependent glucose transporter...
  50. Suzuki H, Nishiyama K, Tokuda H. Coupled structure changes of SecA and SecG revealed by the synthetic lethality of the secAcsR11 and delta secG::kan double mutant. Mol Microbiol. 1998;29:331-41 pubmed
    ..We conclude that SecG and SecA undergo a coupled structure change, that is critical for efficient protein translocation. ..
  51. Nakamura N, Yamamoto A, Wada Y, Futai M. Syntaxin 7 mediates endocytic trafficking to late endosomes. J Biol Chem. 2000;275:6523-9 pubmed
    ..These results also suggest that the biosynthetic pathway utilizes a different machinery from that of the endocytic pathway in the docking/fusion to late endosomes. ..
  52. Fujihara T, Murakami T, Fujita H, Nakamura M, Nakata K. Improvement of corneal barrier function by the P2Y(2) agonist INS365 in a rat dry eye model. Invest Ophthalmol Vis Sci. 2001;42:96-100 pubmed
    ..These effects suggest that INS365 is a potential therapeutic agent for use in the treatment of dry eye syndrome. ..
  53. Hayashi M, Itoh M, Araki S, Kumada S, Shioda K, Tamagawa K, et al. Oxidative stress and disturbed glutamate transport in hereditary nucleotide repair disorders. J Neuropathol Exp Neurol. 2001;60:350-6 pubmed
    ..These data suggest that oxidative stress and disturbed glutamate transport may be involved in pallidal and/or cerebellar degeneration in hereditary nucleotide repair disorders. ..
  54. Miyauchi Y, Michigami T, Sakaguchi N, Sekimoto T, Yoneda Y, Pike J, et al. Importin 4 is responsible for ligand-independent nuclear translocation of vitamin D receptor. J Biol Chem. 2005;280:40901-8 pubmed
    ..In conclusion, importin 4, not importin beta, is responsible for the ligand-independent nuclear translocation of VDR. ..
  55. Morimoto E, Kanai Y, Kim D, Chairoungdua A, Choi H, Wempe M, et al. Establishment and characterization of mammalian cell lines stably expressing human L-type amino acid transporters. J Pharmacol Sci. 2008;108:505-16 pubmed
  56. Furuichi Y, Sugiura T, Kato Y, Shimada Y, Masuda K. OCTN2 is associated with carnitine transport capacity of rat skeletal muscles. Acta Physiol (Oxf). 2010;200:57-64 pubmed publisher
    ..OCTN2 is functionally expressed in skeletal muscles and is involved in the import of carnitine for fatty acid oxidation, especially in highly oxidative muscles. ..
  57. Sadakata T, Sekine Y, Oka M, Itakura M, Takahashi M, Furuichi T. Calcium-dependent activator protein for secretion 2 interacts with the class II ARF small GTPases and regulates dense-core vesicle trafficking. FEBS J. 2012;279:384-94 pubmed publisher
    ..These results for CAPS2 strongly support our idea that the CAPS family proteins exert dual roles in DCV trafficking, mediating trafficking at both the secretion site for exocytosis and at the Golgi complex for biogenesis...
  58. Shiga H, Taki J, Washiyama K, Yamamoto J, Kinase S, Okuda K, et al. Assessment of olfactory nerve by SPECT-MRI image with nasal thallium-201 administration in patients with olfactory impairments in comparison to healthy volunteers. PLoS ONE. 2013;8:e57671 pubmed publisher
    ..Assessment of the (201)Tl migration to the olfactory bulb was the new method for the evaluation of the olfactory nerve connectivity in patients with impaired olfaction. ..
  59. Viens P, Dubeau M, Kimura A, Desaki Y, Shinya T, Shibuya N, et al. Uptake of chitosan-derived D-glucosamine oligosaccharides in Streptomyces coelicolor A3(2). FEMS Microbiol Lett. 2015;362: pubmed publisher
    ..coelicolor A3(2). The ATP-binding component MsiK was essential for CsnEFG transport function. Also, deletion of msiK abolished the induction of csnA transcription by GlcN oligosaccharides. ..
  60. Hasegawa H, Kiyokawa E, Tanaka S, Nagashima K, Gotoh N, Shibuya M, et al. DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane. Mol Cell Biol. 1996;16:1770-6 pubmed
    ..These results suggest that DOCK180 is a new effector molecule which transduces signals from tyrosine kinases through the CRK adaptor protein. ..
  61. Ishiwata K, Noguchi J, Ishii S, Hatano K, Ito K, Nabeshima T, et al. Synthesis and preliminary evaluation of [11C]NE-100 labeled in two different positions as a PET sigma receptor ligand. Nucl Med Biol. 1998;25:195-202 pubmed
    ..These results show that [O-methyl-11C]NE-100 has limited potential as a PET ligand for mapping sigma 1 receptors in the peripheral organs and the CNS because of high nonspecific binding. ..
  62. Hirokawa N, Noda Y, Tanaka Y, Niwa S. Kinesin superfamily motor proteins and intracellular transport. Nat Rev Mol Cell Biol. 2009;10:682-96 pubmed publisher
    ..These findings open exciting new areas of kinesin research. ..
  63. Kita A, Li C, Yu Y, Umeda N, Doi A, Yasuda M, et al. Role of the Small GTPase Rho3 in Golgi/Endosome trafficking through functional interaction with adaptin in Fission Yeast. PLoS ONE. 2011;6:e16842 pubmed publisher
    ..To the best of our knowledge, this study provides the first evidence of a direct link between the small GTPase Rho and the clathrin-associated adaptor protein-1 in membrane trafficking. ..
  64. Sugiura A, Nakashima K, Tanaka K, Mizuno T. Clarification of the structural and functional features of the osmoregulated kdp operon of Escherichia coli. Mol Microbiol. 1992;6:1769-76 pubmed
    ..e. in addition to them, a cis-acting sequence located upstream of the -35 region was essential for full activation of the promoter. This upstream sequence was demonstrated to be the target site for the trans-acting activator, KdpE. ..
  65. Sugawara T, Kinoshita M, Ohnishi M, Tsuzuki T, Miyazawa T, Nagata J, et al. Efflux of sphingoid bases by P-glycoprotein in human intestinal Caco-2 cells. Biosci Biotechnol Biochem. 2004;68:2541-6 pubmed
    ..Thus P-glycoprotein probably contributes to the selective absorption of sphingosine from dietary sphingolipids in the digestive tract. ..
  66. Terada T, Saito H, Mukai M, Inui K. Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells. Am J Physiol. 1997;273:F706-11 pubmed
  67. Kamisako T, Ogawa H. Effects of pravastatin and bezafibrate on biliary lipid excretion and hepatic expression of Abcg5 and Abcg8 in the rat. J Gastroenterol Hepatol. 2004;19:879-83 pubmed
    ..To explore the mechanism, the hepatic expression of genes that are responsible for the metabolism of the lipids was studied...
  68. Mizuarai S, Miki S, Araki H, Takahashi K, Kotani H. Identification of dicarboxylate carrier Slc25a10 as malate transporter in de novo fatty acid synthesis. J Biol Chem. 2005;280:32434-41 pubmed
  69. Tamaki H, Satoh H, Hori S, Ohtani H, Sawada Y. Inhibitory effects of herbal extracts on breast cancer resistance protein (BCRP) and structure-inhibitory potency relationship of isoflavonoids. Drug Metab Pharmacokinet. 2010;25:170-9 pubmed
    ..Thus, some herbal and dietary supplements and isoflavonoids may increase the systemic availability of BCRP substrates when concomitantly given orally. ..
  70. Ezaki B, Mori H, Ogura T, Hiraga S. Possible involvement of the ugpA gene product in the stable maintenance of mini-F plasmid in Escherichia coli. Mol Gen Genet. 1990;223:361-8 pubmed
    ..We generated a disrupted ugpA null mutant and found that the mini-F plasmid was unstable in this ugpA null mutant even at 30 degrees C. This suggests that the ugpA gene product is required for the stable maintenance of mini-F plasmid. ..
  71. Yamaguchi H, Takeuchi T, Okada M, Kobayashi M, Unno M, Abe T, et al. Screening of antibiotics that interact with organic anion-transporting polypeptides 1B1 and 1B3 using fluorescent probes. Biol Pharm Bull. 2011;34:389-95 pubmed
    ..Our results indicate that OATP1B1 and/or OATP1B3 contribute to the transport process of some antibiotics, and that drug-drug interactions associated with these transporters could occur after the administration of antibiotics. ..
  72. Nakashima K, Sugiura A, Momoi H, Mizuno T. Phosphotransfer signal transduction between two regulatory factors involved in the osmoregulated kdp operon in Escherichia coli. Mol Microbiol. 1992;6:1777-84 pubmed
    ..We also developed a procedure for preparing cytoplasmic membrane enriched with the KdpD protein that exhibits in vitro ability with regard to phosphorylation of KdpE protein. ..
  73. Hashimoto K, Goromaru T. High-affinity [3H]6-nitroquipazine binding to the 5-hydroxytryptamine transport system in rat lung. Biochem Pharmacol. 1991;41:1679-82 pubmed
    ..The present results suggest that [3H]6-nitroquipazine binding sites in the rat lung are associated with the uptake system of 5-HT. ..
  74. Toyohara H, Yamamoto S, Hosoi M, Takagi M, Hayashi I, Nakao K, et al. Scallop DMT functions as a Ca2+ transporter. FEBS Lett. 2005;579:2727-30 pubmed
    ..Scallop DMT distinctly functions as a Ca(2+) transporter unlike other DMTs, however, it also transports Fe(2+) and Cd(2+) similar to them. ..
  75. Semenova I, Gupta D, Usui T, Hayakawa I, Cowan A, Rodionov V. Stimulation of microtubule-based transport by nucleation of microtubules on pigment granules. Mol Biol Cell. 2017;28:1418-1425 pubmed publisher
    ..We conclude that generation of new MT transport tracks by concentration of the leading pigment granules provides a positive feedback loop that enhances delivery of trailing granules to the cell center. ..
  76. Yanatori I, Richardson D, Toyokuni S, Kishi F. The iron chaperone poly(rC)-binding protein 2 forms a metabolon with the heme oxygenase 1/cytochrome P450 reductase complex for heme catabolism and iron transfer. J Biol Chem. 2017;292:13205-13229 pubmed publisher
    ..These results indicate that ferrous iron released from heme can be bound by PCBP2 and suggest a model for an integrated heme catabolism and iron transport metabolon. ..
  77. Kabuto M, Kubota T, Kobayashi H, Nakagawa T, Arai Y, Kitai R. Subcellular localization and cellular pharmacokinetics of MX2, a new morpholino anthracycline in glioma cells using confocal laser scanning microscopy. Neurol Res. 1994;16:257-64 pubmed
    ..It is considered that the CLSM technique is useful for the study of the cellular pharmacokinetics of antitumour agents such as anthracycline derivatives. ..
  78. Tero A, Kobayashi R, Nakagaki T. A mathematical model for adaptive transport network in path finding by true slime mold. J Theor Biol. 2007;244:553-64 pubmed
    ..Our model contains a key parameter corresponding to the extent of the feedback regulation between the thickness of a tube and the flux through it. We demonstrate the dependence of the behavior of the model on this parameter...
  79. Ishimi Y, Sugiyama T, Nakaya R, Kanamori M, Kohno T, Enomoto T, et al. Effect of heliquinomycin on the activity of human minichromosome maintenance 4/6/7 helicase. FEBS J. 2009;276:3382-91 pubmed publisher
    ..2 microM inhibited the ATPase activity of the MCM4/6/7 complex in the presence of single-stranded DNA. This suggests that heliquinomycin interferes with the interaction of the MCM4/6/7 complex with single-stranded DNA. ..
  80. Sakudoh T, Kuwazaki S, Iizuka T, Narukawa J, Yamamoto K, Uchino K, et al. CD36 homolog divergence is responsible for the selectivity of carotenoid species migration to the silk gland of the silkworm Bombyx mori. J Lipid Res. 2013;54:482-95 pubmed publisher
    ..Our findings indicate that divergence of genes in the CD36 family determines the selectivity of carotenoid species uptake by silk gland tissue and that CD36-homologous proteins can discriminate among carotenoid species...
  81. Tabuchi M, Tanaka N, Iwahara S, Takegawa K. The Schizosaccharomyces pombe gms1+ gene encodes an UDP-galactose transporter homologue required for protein galactosylation. Biochem Biophys Res Commun. 1997;232:121-5 pubmed
    ..These results showed that the gms1+ encodes an UDP-galactose transporter, and this protein appears to be an essential role for the incorporation of UDP-galactose into the lumen of Golgi in s. pombe. ..
  82. Iseki K, Sugawara M, Saitoh H, Miyazaki K, Arita T. Comparison of transport characteristics of amino beta-lactam antibiotics and dipeptides across rat intestinal brush border membrane. J Pharm Pharmacol. 1989;41:628-32 pubmed
    ..These results suggest that the contribution of the inward H+ gradient to the permeation of ampicillin, cephradine and glycylglycine across the rat small intestinal brush border membranes is different for each of the substances examined. ..
  83. Yamashita A, Watanabe Y, Nukina N, Yamamoto M. RNA-assisted nuclear transport of the meiotic regulator Mei2p in fission yeast. Cell. 1998;95:115-23 pubmed
    ..These results indicate that meiRNA contributes to the promotion of meiosis I exclusively as a cofactor that assists nuclear transport of Mei2p. ..
  84. Fujita T, Maturana A, Ikuta J, Hamada J, Walchli S, Suzuki T, et al. Axonal guidance protein FEZ1 associates with tubulin and kinesin motor protein to transport mitochondria in neurites of NGF-stimulated PC12 cells. Biochem Biophys Res Commun. 2007;361:605-10 pubmed
    ..Thus, our results suggest that the FEZ1/kinesin complex functions for the transport of mitochondria along microtubules toward the extending neurites in differentiating PC12 cells. ..
  85. Uwai Y, Honjo H, Iwamoto K. Interaction and transport of kynurenic acid via human organic anion transporters hOAT1 and hOAT3. Pharmacol Res. 2012;65:254-60 pubmed publisher
    ..These findings show the interaction of kynurenic acid with hOAT1 and hOAT3, and that kynurenic acid is their substrate. It is suggested that these transporters are involved in the disposition of kynurenic acid. ..
  86. Takahashi N, Fujibayashi Y, Yonekura Y, Welch M, Waki A, Tsuchida T, et al. Copper-62 ATSM as a hypoxic tissue tracer in myocardial ischemia. Ann Nucl Med. 2001;15:293-6 pubmed
    ..This preliminary study suggests that 62Cu-ATSM is a promising PET tracer for hypoxic imaging in acute ischemia. ..
  87. Nakagawa R, Hara Y, Arakawa H, Nishimura S, Komatani H. ABCG2 confers resistance to indolocarbazole compounds by ATP-dependent transport. Biochem Biophys Res Commun. 2002;299:669-75 pubmed
    ..These results showed that ABCG2 confers resistance to indolocarbazoles by transporting them in an energy-dependent manner...
  88. Igarashi K. [Physiological functions of polyamines and regulation of polyamine content in cells]. Yakugaku Zasshi. 2006;126:455-71 pubmed
    ..Increased levels of polyamine oxidase and acrolein are good markers of chronic renal failure and brain stroke. ..
  89. Shirasaka Y, Suzuki K, Shichiri M, Nakanishi T, Tamai I. Intestinal absorption of HMG-CoA reductase inhibitor pitavastatin mediated by organic anion transporting polypeptide and P-glycoprotein/multidrug resistance 1. Drug Metab Pharmacokinet. 2011;26:171-9 pubmed
    ..Our present results indicate that OATP/Oatp and MDR1/Mdr1 play roles in the intestinal absorption of pitavastatin as influx and efflux transporters, respectively. ..
  90. Ueki T, Furuno N, Michibata H. A novel vanadium transporter of the Nramp family expressed at the vacuole of vanadium-accumulating cells of the ascidian Ascidia sydneiensis samea. Biochim Biophys Acta. 2011;1810:457-64 pubmed publisher
    ..Vanadium is an essential transition metal in biological systems. Several key proteins related to vanadium accumulation and its physiological function have been isolated, but no vanadium ion transporter has yet been identified...
  91. Oka T, Nakano A. Inhibition of GTP hydrolysis by Sar1p causes accumulation of vesicles that are a functional intermediate of the ER-to-Golgi transport in yeast. J Cell Biol. 1994;124:425-34 pubmed
  92. Nonaka M, Ma B, Ohtani M, Yamamoto A, Murata M, Totani K, et al. Subcellular localization and physiological significance of intracellular mannan-binding protein. J Biol Chem. 2007;282:17908-20 pubmed
    ..These results strongly indicate that I-MBP may function as a cargo transport lectin facilitating ER-to-Golgi traffic in glycoprotein quality control. ..