Experts and Doctors on binding sites in France


Locale: France
Topic: binding sites

Top Publications

  1. Leveillard T, Andera L, Bissonnette N, Schaeffer L, Bracco L, Egly J, et al. Functional interactions between p53 and the TFIIH complex are affected by tumour-associated mutations. EMBO J. 1996;15:1615-24 pubmed
    ..We hypothesize that the interactions provide an immediate and direct link for p53 to the multiple functions of TFIIH in transcription, DNA repair and possibly the cell cycle. ..
  2. Dauplais M, Lecoq A, Song J, Cotton J, Jamin N, Gilquin B, et al. On the convergent evolution of animal toxins. Conservation of a diad of functional residues in potassium channel-blocking toxins with unrelated structures. J Biol Chem. 1997;272:4302-9 pubmed
    ..Therefore, toxins that have unrelated structures but similar functions possess conserved key functional residues, organized in an identical topology, suggesting a convergent functional evolution for these small proteins. ..
  3. Serrano N, Brock H, Maschat F. beta3-tubulin is directly repressed by the engrailed protein in Drosophila. Development. 1997;124:2527-36 pubmed
    ..Finally, two different sets of Engrailed binding sites are shown to be involved in the early and late regulation of beta3-tubulin by Engrailed during embryogenesis. ..
  4. Thenot S, Bonnet S, Boulahtouf A, Margeat E, Royer C, Borgna J, et al. Effect of ligand and DNA binding on the interaction between human transcription intermediary factor 1alpha and estrogen receptors. Mol Endocrinol. 1999;13:2137-50 pubmed
    ..Finally, we show that, mainly in the absence of hormone, hTIF1alpha interacts better with ERbeta than with ERalpha independently of the presence of ERE. ..
  5. Prevot D, Voeltzel T, Birot A, Morel A, Rostan M, Magaud J, et al. The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation. J Biol Chem. 2000;275:147-53 pubmed
    ..Our data indicate that Btg1 and Btg2 act as transcriptional cofactors of the Hoxb9 protein, and suggest that this interaction may mediate their antiproliferative function. ..
  6. Burmeister W, Cottaz S, Rollin P, Vasella A, Henrissat B. High resolution X-ray crystallography shows that ascorbate is a cofactor for myrosinase and substitutes for the function of the catalytic base. J Biol Chem. 2000;275:39385-93 pubmed
  7. Alvarez J, Hamplova J, Hohaus A, Morano I, Haase H, Vassort G. Calcium current in rat cardiomyocytes is modulated by the carboxyl-terminal ahnak domain. J Biol Chem. 2004;279:12456-61 pubmed
  8. Molle V, Soulat D, Jault J, Grangeasse C, Cozzone A, Prost J. Two FHA domains on an ABC transporter, Rv1747, mediate its phosphorylation by PknF, a Ser/Thr protein kinase from Mycobacterium tuberculosis. FEMS Microbiol Lett. 2004;234:215-23 pubmed
    ..This reaction appears to involve two FHA domains of Rv1747. It is suggested that recruitment and phosphorylation of Rv1747 depend on the interaction between its two non-redundant FHA domains and the autophosphorylated form of PknF...
  9. Perret D, Guillet C, Elson G, Froger J, Plun Favreau H, Rousseau F, et al. Two different contact sites are recruited by cardiotrophin-like cytokine (CLC) to generate the CLC/CLF and CLC/sCNTFRalpha composite cytokines. J Biol Chem. 2004;279:43961-70 pubmed
    ..This study establishes the molecular details of the interaction of CLC with CLF, CNTFRalpha, and LIFRbeta and helps to define the precise role of each protein in this functional receptor complex. ..

More Information

Publications471 found, 100 shown here

  1. Stamboulian S, Moutin M, Treves S, Pochon N, Grunwald D, Zorzato F, et al. Junctate, an inositol 1,4,5-triphosphate receptor associated protein, is present in rodent sperm and binds TRPC2 and TRPC5 but not TRPC1 channels. Dev Biol. 2005;286:326-37 pubmed
    ..Altogether, these results provide a new hypothesis concerning sperm TRPC2 gating: TRPC2 activation may be due to modifications of its interaction with both junctate and IP3R, induced by depletion of calcium from the acrosomal vesicle. ..
  2. Brier S, Lemaire D, DeBonis S, Forest E, Kozielski F. Molecular dissection of the inhibitor binding pocket of mitotic kinesin Eg5 reveals mutants that confer resistance to antimitotic agents. J Mol Biol. 2006;360:360-76 pubmed
    ..These results suggest that tumour cells might develop resistance to Eg5 inhibitors, by expressing Eg5 point mutants that retain the enzyme activity, but prevent inhibition, a feature that is observed for certain tubulin inhibitors. ..
  3. Garcia Saez I, Tcherniuk S, Kozielski F. The structure of human neuronal Rab6B in the active and inactive form. Acta Crystallogr D Biol Crystallogr. 2006;62:725-33 pubmed
    ..Compared with other Rab proteins, additional changes are observed in the Rab6 subfamily-specific RabSF3 region that might contribute to the specificity of Rab6 for its different effector proteins. ..
  4. Mokrani H, Sharaf el Dein O, Mansuroglu Z, Bonnefoy E. Binding of YY1 to the proximal region of the murine beta interferon promoter is essential to allow CBP recruitment and K8H4/K14H3 acetylation on the promoter region after virus infection. Mol Cell Biol. 2006;26:8551-61 pubmed
  5. Fermas S, Gonnet F, Varenne A, Gareil P, Daniel R. Frontal analysis capillary electrophoresis hyphenated to electrospray ionization mass spectrometry for the characterization of the antithrombin/heparin pentasaccharide complex. Anal Chem. 2007;79:4987-93 pubmed
    ..This FACE-ESIMS strategy opens the way to ligand fishing experiments performed on heterogeneous carbohydrate mixtures and subsequent characterization of specifically bound carbohydrates. ..
  6. Smet Nocca C, Wieruszeski J, Chaar V, Leroy A, Benecke A. The thymine-DNA glycosylase regulatory domain: residual structure and DNA binding. Biochemistry. 2008;47:6519-30 pubmed publisher
    ..T mismatch processing activity of TDG. ..
  7. Hock M, Kraus I, Schoehn G, Jamin M, Andrei Selmer C, Garten W, et al. RNA induced polymerization of the Borna disease virus nucleoprotein. Virology. 2010;397:64-72 pubmed publisher
    ..Our data indicate that BDV N utilizes similar structural principles for N-RNA and N-P-RNA complex formation as observed for related negative strand RNA viruses. ..
  8. Gaffé J, Lemercier C, Alcaraz J, Kuntz M. Identification of three tomato flower and fruit MADS-box proteins with a putative histone deacetylase binding domain. Gene. 2011;471:19-26 pubmed publisher
    ..Our data suggest that, like mammalian MEF2A, plant MADS-box transcriptional activity might be regulated by enzymes controlling chromatin acetylation. ..
  9. Ruault M, De Meyer A, Loiodice I, Taddei A. Clustering heterochromatin: Sir3 promotes telomere clustering independently of silencing in yeast. J Cell Biol. 2011;192:417-31 pubmed publisher
    ..We propose that similar mechanisms involving proteins able to oligomerize account for long-range interactions that impact genomic functions in many organisms. ..
  10. Bushmarina N, Tourne S, Giacometti G, Signorino Gelo F, Garcia Alles L, Cazenave J, et al. Increased flexibility and liposome-binding capacity of CD1e at endosomal pH. FEBS J. 2011;278:2022-33 pubmed publisher
    ..Altogether, these data indicate that, in the late endosomes/lysosomes of DCs, the acid pH promotes the binding of lipid antigens to CD1e through increased hydrophobic and ionic interactions. ..
  11. Laguri C, Sapay N, Simorre J, Brutscher B, Imberty A, Gans P, et al. 13C-labeled heparan sulfate analogue as a tool to study protein/heparan sulfate interactions by NMR spectroscopy: application to the CXCL12? chemokine. J Am Chem Soc. 2011;133:9642-5 pubmed publisher
    ..This new approach provides a foundation for further investigations of protein/HS interactions and should find wide application. ..
  12. Bourhis J, Vadon Le Goff S, Afrache H, Mariano N, Kronenberg D, Thielens N, et al. Procollagen C-proteinase enhancer grasps the stalk of the C-propeptide trimer to boost collagen precursor maturation. Proc Natl Acad Sci U S A. 2013;110:6394-9 pubmed publisher
    ..Together with detailed kinetics and interaction analysis, these results provide insights into the mechanism of action of PCPEs and suggest clear strategies for the development of novel antifibrotic therapies. ..
  13. Klaholz B, Renaud J, Mitschler A, Zusi C, Chambon P, Gronemeyer H, et al. Conformational adaptation of agonists to the human nuclear receptor RAR gamma. Nat Struct Biol. 1998;5:199-202 pubmed
  14. Sallmann F, Baveye Descamps S, Pattus F, Salmon V, Branza N, Spik G, et al. Porins OmpC and PhoE of Escherichia coli as specific cell-surface targets of human lactoferrin. Binding characteristics and biological effects. J Biol Chem. 1999;274:16107-14 pubmed
    ..These data support the proposal that the antibacterial activity of lactoferrin may depend, at least in part, on its ability to bind to porins, thus modifying the stability and/or the permeability of the bacterial outer membrane. ..
  15. Grizot S, Faure J, Fieschi F, Vignais P, Dagher M, Pebay Peyroula E. Crystal structure of the Rac1-RhoGDI complex involved in nadph oxidase activation. Biochemistry. 2001;40:10007-13 pubmed
    ..In the Rac1-RhoGDI complex, the accessibility of the effector loops of Rac1 probably accounts for the ability of the Rac1-RhoGDI complex to activate the NADPH oxidase. ..
  16. Bouzidi M, Tricaud N, Giraud P, Kordeli E, Caillol G, Deleuze C, et al. Interaction of the Nav1.2a subunit of the voltage-dependent sodium channel with nodal ankyrinG. In vitro mapping of the interacting domains and association in synaptosomes. J Biol Chem. 2002;277:28996-9004 pubmed
    ..However, we could not find conditions that allowed for co-immunoprecipitation of ankyrin with the sodium channel beta(1) subunit. ..
  17. Charron C, Roy H, Blaise M, Gieg R, Kern D. Non-discriminating and discriminating aspartyl-tRNA synthetases differ in the anticodon-binding domain. EMBO J. 2003;22:1632-43 pubmed publisher
    ..Its particular status is demonstrated by a loop-exchange experiment that renders the Pyrococcus AspRS non-discriminating...
  18. Saint Dizier M, Chopineau M, Dupont J, Daels P, Combarnous Y. Expression and binding activity of luteinizing hormone/chorionic gonadotropin receptors in the primary corpus luteum during early pregnancy in the mare. Biol Reprod. 2003;69:1743-9 pubmed
  19. Howard E, Sanishvili R, Cachau R, Mitschler A, Chevrier B, Barth P, et al. Ultrahigh resolution drug design I: details of interactions in human aldose reductase-inhibitor complex at 0.66 A. Proteins. 2004;55:792-804 pubmed
    ..This work demonstrates the capabilities of subatomic resolution experiments and stimulates further developments of methods allowing the use of the full potential of these experiments. ..
  20. Ciais D, Cherradi N, Bailly S, Grenier E, Berra E, Pouyssegur J, et al. Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b. Oncogene. 2004;23:8673-80 pubmed
    ..TIS11b is the first VEGF mRNA-destabilizing protein identified so far and therefore appears as a new potential target in antiangiogenic therapies. ..
  21. Nomin Y, Charbonnier S, Miguet L, Potier N, Van Dorsselaer A, Atkinson R, et al. 1H and 15N resonance assignment, secondary structure and dynamic behaviour of the C-terminal domain of human papillomavirus oncoprotein E6. J Biomol NMR. 2005;31:129-41 pubmed publisher
    ..Investigation of these effects by 15N relaxation experiments showed that they are due to heterogeneous dynamic behaviour with mus-ms time scale motions occurring in localised regions of the monomeric domain...
  22. Perret S, Sabin C, Dumon C, Pokorná M, Gautier C, Galanina O, et al. Structural basis for the interaction between human milk oligosaccharides and the bacterial lectin PA-IIL of Pseudomonas aeruginosa. Biochem J. 2005;389:325-32 pubmed
    ..This study provides important structural information about compounds that could be of general application in new therapeutic strategies against bacterial infections. ..
  23. Auriol E, Billard L, Magdinier F, Dante R. Specific binding of the methyl binding domain protein 2 at the BRCA1-NBR2 locus. Nucleic Acids Res. 2005;33:4243-54 pubmed
    ..Collectively, our data indicate that MBD2 has specific targets and its presence at these targets is indispensable for gene repression. ..
  24. Traor D, El Ghazouani A, Ilango S, Dupuy J, Jacquamet L, Ferrer J, et al. Crystal structure of the apo-PerR-Zn protein from Bacillus subtilis. Mol Microbiol. 2006;61:1211-9 pubmed publisher
    ..The Zn(Cys)4 site locks the dimerization domain and stabilizes the dimer. Sequence alignment of PerR-like proteins supports that this structural site may constitute a distinctive feature of this class of peroxide stress regulators...
  25. Iwema T, Billas I, Beck Y, Bonneton F, Nierengarten H, Chaumot A, et al. Structural and functional characterization of a novel type of ligand-independent RXR-USP receptor. EMBO J. 2007;26:3770-82 pubmed publisher
    ..These findings together with a phylogenetic analysis suggest that RXR-USPs have undergone remarkable functional shifts during evolution and give insight into receptor-ligand binding evolution and dynamics...
  26. Nouet C, Truan G, Mathieu L, Dujardin G. Functional analysis of yeast bcs1 mutants highlights the role of Bcs1p-specific amino acids in the AAA domain. J Mol Biol. 2009;388:252-61 pubmed publisher
  27. Nolivos S, Pages C, Rousseau P, Le Bourgeois P, Cornet F. Are two better than one? Analysis of an FtsK/Xer recombination system that uses a single recombinase. Nucleic Acids Res. 2010;38:6477-89 pubmed publisher
    ..In contrast, both FtsK? and the translocation motor are required to activate XerS/dif(SL) recombination. These findings have implications for the mechanisms by which FtsK activates recombination. ..
  28. Astier C, Chaleix V, Faugeron C, Ropartz D, Gloaguen V, Krausz P. Grafting of aminated oligogalacturonans onto Douglas fir barks. A new route for the enhancement of their lead (II) binding capacities. J Hazard Mater. 2010;182:279-85 pubmed publisher
    ..Derivatization resulted in significant enhancements of the q(max) values (up to x8), along with little change of the affinity parameter. ..
  29. Bastet L, Boileau C, Bédu S, Janicki A, Latifi A, Zhang C. NtcA regulates patA expression in Anabaena sp. strain PCC 7120. J Bacteriol. 2010;192:5257-9 pubmed publisher
    ..The patA promoter region shows two conserved NtcA-binding boxes. These NtcA-binding sites and their interaction with NtcA are key elements for patA expression in heterocysts. ..
  30. El Hammi E, Warkentin E, Demmer U, Limam F, Marzouki N, Ermler U, et al. Structure of Ralstonia eutropha flavohemoglobin in complex with three antibiotic azole compounds. Biochemistry. 2011;50:1255-64 pubmed publisher
    ..Implications of the observed open-to-closed process on the catalytic cycle are discussed. ..
  31. Quintin J, Le Péron C, Palierne G, Bizot M, Cunha S, Sérandour A, et al. Dynamic estrogen receptor interactomes control estrogen-responsive trefoil Factor (TFF) locus cell-specific activities. Mol Cell Biol. 2014;34:2418-36 pubmed publisher
    ..Hence, our data provide evidence of a formerly suggested cooperation of enhancers toward gene regulation and also show that redundancy between ERBSs can occur. ..
  32. Bodeus M, Marie Cardine A, Bougeret C, Ramos Morales F, Benarous R. In vitro binding and phosphorylation of human immunodeficiency virus type 1 Nef protein by serine/threonine protein kinase. J Gen Virol. 1995;76 ( Pt 6):1337-44 pubmed
    ..The interaction of Nef with cellular kinases and its phosphorylation may be important in mediating the effects of Nef in HIV-1 pathogenesis. ..
  33. Le Provost F, Nocart M, Guerin G, Martin P. Characterization of the goat lactoferrin cDNA: assignment of the relevant locus to bovine U12 synteny group. Biochem Biophys Res Commun. 1994;203:1324-32 pubmed
    ..Since serum transferrin (STF) had been previously mapped on BTA 1, in cattle LTF and STF loci are not localized on the same chromosome, conversely to the situation observed in humans (HSA 3) and mice (MMU 9). ..
  34. Ragusa S, Mouchet P, Lazennec C, Dive V, Meinnel T. Substrate recognition and selectivity of peptide deformylase. Similarities and differences with metzincins and thermolysin. J Mol Biol. 1999;289:1445-57 pubmed
    ..Specific features of PDF with respect to other members of the enzymes with motif HEXXH are discussed. ..
  35. Brodu V, Mugat B, Roignant J, Lepesant J, Antoniewski C. Dual requirement for the EcR/USP nuclear receptor and the dGATAb factor in an ecdysone response in Drosophila melanogaster. Mol Cell Biol. 1999;19:5732-42 pubmed
    ..In addition, we provide further evidence that EcR/USP plays an essential role as a hormonal timer. Our study provides a striking example of the integration of molecular pathways at the level of a tissue-specific hormone response unit. ..
  36. Lemercier C, Brown A, Mamani M, Ripoche J, Reiffers J. The rat Mist1 gene: structure and promoter characterization. Gene. 2000;242:209-18 pubmed
    ..These data suggest that the basal expression of this TATA-less gene might be driven by general transcription factors, such as Sp1. ..
  37. Lascombe M, Gregoire C, Poncet P, Tavares G, Rosinski Chupin I, Rabillon J, et al. Crystal structure of the allergen Equ c 1. A dimeric lipocalin with restricted IgE-reactive epitopes. J Biol Chem. 2000;275:21572-7 pubmed
    ..In addition, total inhibition of IgE serum recognition by a single specific monoclonal antibody revealed the restricted nature of the IgE binding target on the molecular surface of Equ c 1. ..
  38. Peyroche G, Milkereit P, Bischler N, Tschochner H, Schultz P, Sentenac A, et al. The recruitment of RNA polymerase I on rDNA is mediated by the interaction of the A43 subunit with Rrn3. EMBO J. 2000;19:5473-82 pubmed
    ..The existence of mammalian orthologues of A43 and Rrn3 suggests evolutionary conservation of the molecular mechanisms underlying rDNA transcription in eukaryotes. ..
  39. Janody F, Sturny R, Schaeffer V, Azou Y, Dostatni N. Two distinct domains of Bicoid mediate its transcriptional downregulation by the Torso pathway. Development. 2001;128:2281-90 pubmed
    ..The alanine-rich domain contributes to this process indirectly by reducing the global activity of the protein and in particular the activity of the glutamine-rich domain that might otherwise prevent downregulation by Torso. ..
  40. Rabilloud T, Heller M, Gasnier F, Luche S, Rey C, Aebersold R, et al. Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site. J Biol Chem. 2002;277:19396-401 pubmed
  41. Stura E, Graille M, Housden N, Gore M. Protein L mutants for the crystallization of antibody fragments. Acta Crystallogr D Biol Crystallogr. 2002;58:1744-8 pubmed
    ..In this study, we have selected PpL mutants with different behavior and that are most useful for crystallization and we present the various packing modes obtained so far. ..
  42. Sifaoui F, Lamour V, Varon E, Moras D, Gutmann L. ATP-bound conformation of topoisomerase IV: a possible target for quinolones in Streptococcus pneumoniae. J Bacteriol. 2003;185:6137-46 pubmed
    ..Our models of the closed and open conformations of the active site indicate that quinolones preferentially target topoisomerase IV of S. pneumoniae in its ATP-bound closed conformation. ..
  43. Martin D, Daulny A, Decoville M, Locker D. Mutagenesis analysis of the interaction between the dorsal rel homology domain and HMG boxes of DSP1 protein. J Biochem. 2003;134:583-9 pubmed
  44. Stroebel D, Choquet Y, Popot J, Picot D. An atypical haem in the cytochrome b(6)f complex. Nature. 2003;426:413-8 pubmed
    ..This haem is atypical as it is covalently bound by one thioether linkage and has no axial amino acid ligand. This haem may be the missing link in oxygenic photosynthesis. ..
  45. van der Kemp P, Charbonnier J, Audebert M, Boiteux S. Catalytic and DNA-binding properties of the human Ogg1 DNA N-glycosylase/AP lyase: biochemical exploration of H270, Q315 and F319, three amino acids of the 8-oxoguanine-binding pocket. Nucleic Acids Res. 2004;32:570-8 pubmed
    ..C and cleavage of AP sites. Finally, hOgg1 mutant proteins with a substitution of H270A or F319A are members of a new type of hOgg1 that is deficient in DNA glycosylase but proficient in AP lyase. ..
  46. Labialle S, Dayan G, Gayet L, Rigal D, Gambrelle J, Baggetto L. New invMED1 element cis-activates human multidrug-related MDR1 and MVP genes, involving the LRP130 protein. Nucleic Acids Res. 2004;32:3864-76 pubmed
    ..In addition, since the invMED1 sequence is primarily located in the -160/-100 bp region of mammalian MDR-related genes, our results present the invMED1/LRP130 couple as a potential central regulator of the transcription of these genes. ..
  47. Gissot L, Polge C, Bouly J, Lemaitre T, Kreis M, Thomas M. AKINbeta3, a plant specific SnRK1 protein, is lacking domains present in yeast and mammals non-catalytic beta-subunits. Plant Mol Biol. 2004;56:747-59 pubmed
    ..These data suggest the existence of novel SnRK1 complexes including AKINbeta3-type subunits, involved in several functions among which some could be plant specific. ..
  48. Sabin C, Mitchell E, Pokorná M, Gautier C, Utille J, Wimmerova M, et al. Binding of different monosaccharides by lectin PA-IIL from Pseudomonas aeruginosa: thermodynamics data correlated with X-ray structures. FEBS Lett. 2006;580:982-7 pubmed
    ..A combination of the structures and thermodynamics provided clues for the role of the hydrophobic group in affinity. ..
  49. Chomette D, Frain M, Cereghini S, Charnay P, Ghislain J. Krox20 hindbrain cis-regulatory landscape: interplay between multiple long-range initiation and autoregulatory elements. Development. 2006;133:1253-62 pubmed
    ..Together, our studies provide a basis for a model of the molecular mechanisms controlling Krox20 expression in the developing hindbrain and neural crest. ..
  50. Mahul Mellier A, Strappazzon F, Petiot A, Chatellard Causse C, Torch S, Blot B, et al. Alix and ALG-2 are involved in tumor necrosis factor receptor 1-induced cell death. J Biol Chem. 2008;283:34954-65 pubmed publisher
    ..Taken together, these results highlight Alix and ALG-2 as new actors of the TNF-R1 pathway. ..
  51. Lasseur B, Schroeven L, Lammens W, Le Roy K, Spangenberg G, Manduzio H, et al. Transforming a fructan:fructan 6G-fructosyltransferase from perennial ryegrass into a sucrose:sucrose 1-fructosyltransferase. Plant Physiol. 2009;149:327-39 pubmed publisher
    ..Taken together, these insights contribute to our knowledge of structure/function relationships within plant family 32 glycosyl hydrolases and open the way to the production of tailor-made fructans on a larger scale. ..
  52. Clarhaut J, Gemmill R, Potiron V, Ait Si Ali S, Imbert J, Drabkin H, et al. ZEB-1, a repressor of the semaphorin 3F tumor suppressor gene in lung cancer cells. Neoplasia. 2009;11:157-66 pubmed
    ..Moreover, exogenous addition of SEMA3F could modulate ZEB-1-induced angiogenesis in a chorioallantoic membrane assay. Together, these data provide further support for the importance of SEMA3F and ZEB-1 in lung cancer progression. ..
  53. Belin P, Le Du M, Fielding A, Lequin O, Jacquet M, Charbonnier J, et al. Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2009;106:7426-31 pubmed publisher
    ..This study provides insight into the catalytic activity, mechanism, and biological function of CYP121. Also, it provides clues for rational design of putative CYP121 substrate-based antimycobacterial agents...
  54. Meziane Cherif D, Saul F, Moubareck C, Weber P, Haouz A, Courvalin P, et al. Molecular basis of vancomycin dependence in VanA-type Staphylococcus aureus VRSA-9. J Bacteriol. 2010;192:5465-71 pubmed publisher
    ..Ddl drug targeting could therefore be an effective strategy against vancomycin-resistant S. aureus. ..
  55. Dittami S, Michel G, Collén J, Boyen C, Tonon T. Chlorophyll-binding proteins revisited--a multigenic family of light-harvesting and stress proteins from a brown algal perspective. BMC Evol Biol. 2010;10:365 pubmed publisher
  56. Gilot D, Migault M, Bachelot L, Journe F, Rogiers A, Donnou Fournet E, et al. A non-coding function of TYRP1 mRNA promotes melanoma growth. Nat Cell Biol. 2017;19:1348-1357 pubmed publisher
    ..Together, our findings assign a pathogenic non-coding function to TYRP1 mRNA and highlight miRNA displacement as a promising targeted therapeutic approach for melanoma. ..
  57. Moutoussamy S, Renaudie F, Lago F, Kelly P, Finidori J. Grb10 identified as a potential regulator of growth hormone (GH) signaling by cloning of GH receptor target proteins. J Biol Chem. 1998;273:15906-12 pubmed
    ..Our results suggest that Grb10 is a new target for a member of the cytokine receptor family that down-regulates some GH signaling pathways downstream of Jak2 and independently of Stat5. ..
  58. Froment M, Lockridge O, Masson P. Resistance of butyrylcholinesterase to inactivation by ultrasound: effects of ultrasound on catalytic activity and subunit association. Biochim Biophys Acta. 1998;1387:53-64 pubmed
    ..Aromatic/aromatic interactions between the four helical segments are thought to be enhanced by ultrasound-generated pressure...
  59. Sankaranarayanan R, Dock Bregeon A, Rees B, Bovee M, Caillet J, Romby P, et al. Zinc ion mediated amino acid discrimination by threonyl-tRNA synthetase. Nat Struct Biol. 2000;7:461-5 pubmed publisher
    ..This study demonstrates that the zinc ion is neither strictly catalytic nor structural and suggests how the zinc ion ensures that only amino acids that possess a hydroxyl group attached to the beta-position are activated...
  60. Barbier P, Gregoire C, Devred F, Sarrazin M, Peyrot V. In vitro effect of cryptophycin 52 on microtubule assembly and tubulin: molecular modeling of the mechanism of action of a new antimitotic drug. Biochemistry. 2001;40:13510-9 pubmed
  61. Vachette P, Dainese E, Vasyliev V, Di Muro P, Beltramini M, Svergun D, et al. A key structural role for active site type 3 copper ions in human ceruloplasmin. J Biol Chem. 2002;277:40823-31 pubmed
    ..Our results demonstrate that, beyond catalytic activity, the three-copper cluster at the N-terminal-C-terminal interface plays a crucial role in the structural stability of human ceruloplasmin. ..
  62. Baron A, Deval E, Salinas M, Lingueglia E, Voilley N, Lazdunski M. Protein kinase C stimulates the acid-sensing ion channel ASIC2a via the PDZ domain-containing protein PICK1. J Biol Chem. 2002;277:50463-8 pubmed
    ..These data provide the first demonstration of a regulation of ASICs by protein kinase phosphorylation and its potentiation by the partner protein PICK1. ..
  63. Abergel C, Coutard B, Byrne D, Chenivesse S, Claude J, Deregnaucourt C, et al. Structural genomics of highly conserved microbial genes of unknown function in search of new antibacterial targets. J Struct Funct Genomics. 2003;4:141-57 pubmed
  64. Li de la Sierra Gallay I, Pellegrini O, Condon C. Structural basis for substrate binding, cleavage and allostery in the tRNA maturase RNase Z. Nature. 2005;433:657-61 pubmed
    ..Finally, it highlights the extraordinary adaptability of the metallo-hydrolase domain of the beta-lactamase family for the hydrolysis of covalent bonds. ..
  65. Mesplede T, Island M, Christeff N, Petek F, Doly J, Navarro S. The POU transcription factor Oct-1 represses virus-induced interferon A gene expression. Mol Cell Biol. 2005;25:8717-31 pubmed
    ..Finally, the IFN-A expression pattern is modified in Oct-1-deficient MEFs. The broad representation of effective and potent octamer-like sequences within IFN-A promoters suggests an important role for Oct-1 in IFN-A regulation. ..
  66. Mailliet F, Ferry G, Vella F, Berger S, Coge F, Chomarat P, et al. Characterization of the melatoninergic MT3 binding site on the NRH:quinone oxidoreductase 2 enzyme. Biochem Pharmacol. 2005;71:74-88 pubmed
    ..The compounds described in the present paper are new tools for such a task. ..
  67. Vivares D, Arnoux P, Pignol D. A papain-like enzyme at work: native and acyl-enzyme intermediate structures in phytochelatin synthesis. Proc Natl Acad Sci U S A. 2005;102:18848-53 pubmed
    ..GSH hydrolase and PCS activities of the enzyme are discussed in the light of both structures. ..
  68. Manival X, Charron C, Fourmann J, Godard F, Charpentier B, Branlant C. Crystal structure determination and site-directed mutagenesis of the Pyrococcus abyssi aCBF5-aNOP10 complex reveal crucial roles of the C-terminal domains of both proteins in H/ACA sRNP activity. Nucleic Acids Res. 2006;34:826-39 pubmed publisher
    ..By gel filtration assay, we showed that aNOP10 can dimerize in solution. As both residues Y41 and L48 were needed for dimerization, the dimerization likely takes place by interaction of parallel alpha-helices...
  69. Satre M, Mattei S, Aubry L, Gaudet P, Pelosi L, Brandolin G, et al. Mitochondrial carrier family: repertoire and peculiarities of the cellular slime mould Dictyostelium discoideum. Biochimie. 2007;89:1058-69 pubmed publisher
    ..This study provides a focus for mitochondrial carrier analysis in Dictyostelium discoideum...
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