Genomes and Genes
Experts and Doctors on base sequence in United States
Locale: United States
Topic: base sequence
Publications1120 found, 100 shown here
- Gu W, Williams D, Aldrich H, Xie G, Gabriel D, Jensen R. The aroQ and pheA domains of the bifunctional P-protein from Xanthomonas campestris in a context of genomic comparison. Microb Comp Genomics. 1997;2:141-58 pubmed..PheA family of proteins is presented. A serC gene located immediately upstream of X. campestris aroQp.pheA appears to reflect a conserved gene organization, and both may belong to a single transcriptional unit. ..
- Earnhardt J, Qian M, Tu C, Lakkis M, Bergenhem N, Laipis P, et al. The catalytic properties of murine carbonic anhydrase VII. Biochemistry. 1998;37:10837-45 pubmed..This suggests a role for the amino-terminal end in enhancing proton transfer in catalysis by carbonic anhydrase. ..
- Romero Arroyo C, Jordan J, Peacock S, Willby M, Farmer M, Krause D. Mycoplasma pneumoniae protein P30 is required for cytadherence and associated with proper cell development. J Bacteriol. 1999;181:1079-87 pubmed..Finally, the P30 mutants localized the adhesin protein P1 to the terminal organelle, indicating that P30 is not involved in P1 trafficking but may be required for its receptor-binding function...
- Zhang Y, Zhang P, West C. A linking function for the cellulose-binding protein SP85 in the spore coat of Dictyostelium discoideum. J Cell Sci. 1999;112 ( Pt 23):4367-77 pubmed
- Wang X, Chen X, Oh H, Repasky E, Kazim L, Subjeck J. Characterization of native interaction of hsp110 with hsp25 and hsc70. FEBS Lett. 2000;465:98-102 pubmed..Examination of two deletion mutants of hsp110 demonstrated that its peptide-binding domain is required for interaction with hsp25, but not with hsc70. The potential function of the hsp110-hsc70-hsp25 complex is discussed. ..
- Miller T, Szczesna D, Housmans P, Zhao J, de Freitas F, Gomes A, et al. Abnormal contractile function in transgenic mice expressing a familial hypertrophic cardiomyopathy-linked troponin T (I79N) mutation. J Biol Chem. 2001;276:3743-55 pubmed..These mechanisms may contribute to mortality in humans, especially in stimulated contractile states. ..
- Cort J, Mariappan S, Kim C, Park M, Peat T, Waldo G, et al. Solution structure of Pyrobaculum aerophilum DsrC, an archaeal homologue of the gamma subunit of dissimilatory sulfite reductase. Eur J Biochem. 2001;268:5842-50 pubmed
- Ingavale S, van Wamel W, Cheung A. Characterization of RAT, an autolysis regulator in Staphylococcus aureus. Mol Microbiol. 2003;48:1451-66 pubmed..As anticipated, rat appears to be a negative regulator of autolysin genes including lytM and lytN. These data suggest that the rat gene product is an important regulator of autolytic activity in S. aureus...
- Wu J, Ling X, Pan D, Apontes P, Song L, Liang P, et al. Molecular mechanism of inhibition of survivin transcription by the GC-rich sequence-selective DNA binding antitumor agent, hedamycin: evidence of survivin down-regulation associated with drug sensitivity. J Biol Chem. 2005;280:9745-51 pubmed..Drug-induced modulation of survivin gene expression may provide novel approaches for cancer therapeutics. ..
- Yang Z, Colis L, Basu A, Zou Y. Recognition and incision of gamma-radiation-induced cross-linked guanine-thymine tandem lesion G[8,5-Me]T by UvrABC nuclease. Chem Res Toxicol. 2005;18:1339-46 pubmed..Our result suggests that G[8,5-Me]T intrastrand cross-link is more resistant to excision repair in comparison with the T[6,4]T and AAF adducts and thus will likely persist longer in E. coli cells. ..
- Miao V, Coëffet Le Gal M, Nguyen K, Brian P, Penn J, Whiting A, et al. Genetic engineering in Streptomyces roseosporus to produce hybrid lipopeptide antibiotics. Chem Biol. 2006;13:269-76 pubmed..Substantial amounts of nine of these compounds were readily obtained by fermentation, and all displayed antibacterial activity against gram-positive pathogens. ..
- Chun C, Scheetz T, Bonaldo M, Brown B, Clemens A, Crookes Goodson W, et al. An annotated cDNA library of juvenile Euprymna scolopes with and without colonization by the symbiont Vibrio fischeri. BMC Genomics. 2006;7:154 pubmed
- Yang C, Martinez K, Lin H, Tan W. Hybrid molecular probe for nucleic acid analysis in biological samples. J Am Chem Soc. 2006;128:9986-7 pubmed..HMP is capable of selectively detecting nucleic acid targets from cellular samples. ..
- Knutson D, Clagett Dame M. atRA Regulation of NEDD9, a gene involved in neurite outgrowth and cell adhesion. Arch Biochem Biophys. 2008;477:163-74 pubmed publisher..Finally, chromatin immunoprecipitation (ChIP) assays demonstrate that RAR and RXR are bound to the RARE in cells. ..
- Minko I, Kozekov I, Harris T, Rizzo C, Lloyd R, Stone M. Chemistry and biology of DNA containing 1,N(2)-deoxyguanosine adducts of the alpha,beta-unsaturated aldehydes acrolein, crotonaldehyde, and 4-hydroxynonenal. Chem Res Toxicol. 2009;22:759-78 pubmed publisher..DNA polymerases of the DinB family, pol IV in E. coli and pol kappa in human, are implicated in error-free bypass of model acrolein-mediated N(2)-dG secondary adducts, the interstrand cross-links, and the peptide conjugates. ..
- Valarmathi M, Goodwin R, Fuseler J, Davis J, Yost M, Potts J. A 3-D cardiac muscle construct for exploring adult marrow stem cell based myocardial regeneration. Biomaterials. 2010;31:3185-200 pubmed publisher..Thus, this novel 3-D co-culture system provides a useful in vitro model to investigate the functional role and interplay of developing ECMs and BMSCs during cardiomyogenic differentiation. ..
- Jones E, Brewer M, Srinivasan R, Krueger C, Sun G, Charney K, et al. Distal enhancers upstream of the Charcot-Marie-Tooth type 1A disease gene PMP22. Hum Mol Genet. 2012;21:1581-91 pubmed publisher..These studies provide a novel means to identify critical regulatory elements in genes that are required for myelination, and elucidate the functional significance of non-coding genomic rearrangements. ..
- Carey D, Evans D, Stahl R, Asundi V, Conner K, Garbes P, et al. Molecular cloning and characterization of N-syndecan, a novel transmembrane heparan sulfate proteoglycan. J Cell Biol. 1992;117:191-201 pubmed..A ribonuclease protection assay was used to quantitate levels of the core protein mRNA. High levels were found in neonatal rat brain, heart, and Schwann cells. The mRNA was barely detectable in neonatal or adult liver, or adult brain. ..
- Anderson D, Williams D, Tushinski R, Gimpel S, Eisenman J, Cannizzaro L, et al. Alternate splicing of mRNAs encoding human mast cell growth factor and localization of the gene to chromosome 12q22-q24. Cell Growth Differ. 1991;2:373-8 pubmed..Chromosomal in situ hybridization localized the gene to 12q22-q24 in the region predicted by the comparative mapping of the murine Mgf/Sl locus. ..
- Chai K, Chao J, Chao L. Molecular cloning and sequence analysis of the mouse kallikrein-binding protein gene. Biochim Biophys Acta. 1991;1129:127-30 pubmed..The MKBP gene encodes a prepeptide of 417 amino acid residues which exhibits 71% homology with RKBP. A TATA box sequence was located in the 5' flanking region of the MKBP gene by similarity with the consensus sequence TATAAAA. ..
- Bertani L, Campbell J. The isolation and characterization of the gene (dfr1) encoding dihydrofolate reductase (DHFR) in Schizosaccharomyces pombe. Gene. 1994;147:131-5 pubmed..No similarity to other described DNA sequences or proteins could be found for the 5'-half. Southern and Northern blots indicate that the entire insert is present intact in the Sz. pombe genome and produces a 1.7-kb RNA transcript. ..
- Kao L, Peterson J, Ji R, Bender L, Bender A. Interactions between the ankyrin repeat-containing protein Akr1p and the pheromone response pathway in Saccharomyces cerevisiae. Mol Cell Biol. 1996;16:168-78 pubmed..During a screen for proteins that displayed two-hybrid interactions with Akr1p, we identified Ste4p, raising the possibility that an interaction between Akr1p and Ste4p contributes to proper regulation of the pheromone response pathway. ..
- Liang G, Wolfgang C, Chen B, Chen T, Hai T. ATF3 gene. Genomic organization, promoter, and regulation. J Biol Chem. 1996;271:1695-701 pubmed..A possible mechanism implicating the C-Jun NH2-terminal kinase/stress-activated protein kinase (JNK/SAPK) stress-inducible signaling pathway in the induction of the ATF3 gene is discussed. ..
- Hogan L, Klein B. Transforming DNA integrates at multiple sites in the dimorphic fungal pathogen Blastomyces dermatitidis. Gene. 1997;186:219-26 pubmed..Molecular genetic manipulation of B. dermatitidis represents a major advance in our ability to investigate the pathogenesis of blastomycosis and other similar fungal diseases. ..
- Kim V, Green W. The role of proximal and distal sequence variations in the presentation of an immunodominant CTL epitope encoded by the ecotropic AK7 MuLV. Virology. 1997;236:221-33 pubmed..Interestingly, our data indicate that the enhancer region derived from AK7 negatively influences the presentation of KSPWFTTL in the context of a recombinant AKR623 virus...
- Jones G, Sharp P. Ultraspiracle: an invertebrate nuclear receptor for juvenile hormones. Proc Natl Acad Sci U S A. 1997;94:13499-503 pubmed..We propose that regulation of morphogenetic transitions in invertebrates involves binding of JH or JH-like structures to USP. ..
- Bertani L, Huang J, Weir B, Kirschvink J. Evidence for two types of subunits in the bacterioferritin of Magnetospirillum magnetotacticum. Gene. 1997;201:31-6 pubmed..Differences in heme- and metal-binding sites and ferroxidase activities of the two types of subunits are discussed. ..
- Roberts T, Chernova O, Cowell J. NB4S, a member of the TBC1 domain family of genes, is truncated as a result of a constitutional t(1;10)(p22;q21) chromosome translocation in a patient with stage 4S neuroblastoma. Hum Mol Genet. 1998;7:1169-78 pubmed..The chromosome rearrangement creates a fusion gene product which combines the TBC1 motif of NB4S with a polyadenylation signal from TRNG10 , potentially generating a truncated protein with oncogenic properties. ..
- Du X, P ne J. Identification, cloning and expression of p25, an AT-rich DNA-binding protein from the extreme thermophile, Thermus aquaticus YT-1. Nucleic Acids Res. 1999;27:1690-7 pubmed..Overexpression study of fusion p25 suggested that the N-terminus of the protein might form the DNA-binding domain or be closely involved in DNA-binding activity...
- You S, Falgout B, Markoff L, Padmanabhan R. In vitro RNA synthesis from exogenous dengue viral RNA templates requires long range interactions between 5'- and 3'-terminal regions that influence RNA structure. J Biol Chem. 2001;276:15581-91 pubmed publisher..RNA synthesis at the 3'-UTR, however, requires long range interactions involving the 5'-UTR, CYC motifs, and the 3'-stem-loop region that includes the tertiary pseudoknot structure...
- Filippova G, Qi C, Ulmer J, Moore J, Ward M, Hu Y, et al. Tumor-associated zinc finger mutations in the CTCF transcription factor selectively alter tts DNA-binding specificity. Cancer Res. 2002;62:48-52 pubmed..These observations suggest that CTCF may represent a novel tumor suppressor gene that displays tumor-specific "change of function" rather than complete "loss of function." ..
- De La Fuente J, Van Den Bussche R, Garcia Garcia J, Rodríguez S, Garcia M, Guglielmone A, et al. Phylogeography of New World isolates of Anaplasma marginale based on major surface protein sequences. Vet Microbiol. 2002;88:275-85 pubmed..marginale isolates. In contrast MSP1a sequences appeared to be rapidly evolving and these sequences may provide phylogeographic information only when numerous isolate MSP1a sequences are analyzed from a geographic area...
- Toribio R, Kohn C, Leone G, Capen C, Rosol T. Molecular cloning and expression of equine calcitonin, calcitonin gene-related peptide-I, and calcitonin gene-related peptide-II. Mol Cell Endocrinol. 2003;199:119-28 pubmed..CGRPs are widely expressed in tissues of the central and peripheral nervous system. Information from this study will be valuable to study the role of CT, CGRP-I, and CGRP-II in equine health and disease. ..
- Nichols N, Dien B, Bothast R. Engineering lactic acid bacteria with pyruvate decarboxylase and alcohol dehydrogenase genes for ethanol production from Zymomonas mobilis. J Ind Microbiol Biotechnol. 2003;30:315-21 pubmed..However, lactic acid was the primary fermentation product formed by all of the transformants, indicating that ADH and PDC activities were insufficient to divert significant carbon flow towards ethanol...
- Langat D, Morales P, Fazleabas A, Hunt J. Potential regulatory sequences in the untranslated regions of the baboon MHC class Ib gene, Paan-AG, more closely resemble those in the human MHC class Ia genes than those in the class Ib gene, HLA-G. Immunogenetics. 2004;56:657-66 pubmed
- Huang J, Petersen A, Whiteley M, Leadbetter J. Identification of QuiP, the product of gene PA1032, as the second acyl-homoserine lactone acylase of Pseudomonas aeruginosa PAO1. Appl Environ Microbiol. 2006;72:1190-7 pubmed publisher..It is not yet known under which "natural" conditions quiP is expressed or how P. aeruginosa balances the expression of its quorum-sensing systems with the expression of its acyl-HSL acylase activities...
- Mao G, Pan X, Zhu B, Zhang Y, Yuan F, Huang J, et al. Identification and characterization of OGG1 mutations in patients with Alzheimer's disease. Nucleic Acids Res. 2007;35:2759-66 pubmed..Our findings suggest that defects in OGG1 may be important in the pathogenesis of AD in a significant fraction of AD patients and provide new insight into the molecular basis for the disease. ..
- Ling J, Roy H, Qin D, Rubio M, Alfonzo J, Fredrick K, et al. Pathogenic mechanism of a human mitochondrial tRNAPhe mutation associated with myoclonic epilepsy with ragged red fibers syndrome. Proc Natl Acad Sci U S A. 2007;104:15299-304 pubmed..This variant enzyme displayed significantly improved aminoacylation efficiency for the G34A mutant, suggesting a general strategy to treat certain classes of mitochondrial diseases by modification of the corresponding nuclear gene...
- Bhaskaran H, Russell R. Kinetic redistribution of native and misfolded RNAs by a DEAD-box chaperone. Nature. 2007;449:1014-8 pubmed..Conversely, RNAs whose functions depend on forming multiple conformations may rely on DExD/H-box proteins to increase the populations of less stable conformations, thereby increasing their overall efficiencies. ..
- Zhang W, Lee H, Koo D, Jiang J. Epigenetic modification of centromeric chromatin: hypomethylation of DNA sequences in the CENH3-associated chromatin in Arabidopsis thaliana and maize. Plant Cell. 2008;20:25-34 pubmed publisher..Our results suggest that DNA methylation plays an important role in epigenetic demarcation of the CEN chromatin. ..
- Cao Y, Wang L, Nandy D, Zhang Y, Basu A, Radisky D, et al. Neuropilin-1 upholds dedifferentiation and propagation phenotypes of renal cell carcinoma cells by activating Akt and sonic hedgehog axes. Cancer Res. 2008;68:8667-72 pubmed publisher..Inhibition of sonic hedgehog expression can be reversed by DeltaNp63alpha overexpression. Our study reveals that NRP-1 helps maintain an undifferentiated phenotype in cancer cells. ..
- Liu B, Liang X, Piekna Przybylska D, Liu Q, Fournier M. Mis-targeted methylation in rRNA can severely impair ribosome synthesis and activity. RNA Biol. 2008;5:249-54 pubmed..These findings imply that nucleotide modifications can serve as evolutionary constraints and that snoRNP mutations expected to occur in nature can cause human disease. ..
- Fang P, Schwartz I, Johnson B, Derr M, Roberts C, Hwa V, et al. Familial short stature caused by haploinsufficiency of the insulin-like growth factor i receptor due to nonsense-mediated messenger ribonucleic acid decay. J Clin Endocrinol Metab. 2009;94:1740-7 pubmed publisher..The mutation results in haploinsufficiency of IGF1R protein due to nonsense-mediated mRNA decay and is associated with familial short stature. ..
- Waidner L, Morgan R, Anderson A, Bernberg E, Kamboj S, Garcia M, et al. MicroRNAs of Gallid and Meleagrid herpesviruses show generally conserved genomic locations and are virus-specific. Virology. 2009;388:128-36 pubmed publisher..The prevalence of microRNAs in the genomic repeat regions as well as in local repeats suggests the importance of genetic plasticity in herpesviruses for microRNA evolution and preservation of function. ..
- Kim S, McKay R, Miller K, Shortridge R. Multiple subtypes of phospholipase C are encoded by the norpA gene of Drosophila melanogaster. J Biol Chem. 1995;270:14376-82 pubmed..The amino acid differences between the two subtypes of norpA protein may reflect the need for each subtype to interact with signaling components of different signal-generating pathways. ..
- de Vetten N, Lu G, Feri R. A maize protein associated with the G-box binding complex has homology to brain regulatory proteins. Plant Cell. 1992;4:1295-307 pubmed..This suggests a deep evolutionary conservation of a potential regulatory protein associated with a core sequence found in the promoter region of many genes. ..
- Fathi Z, Condit R. Genetic and molecular biological characterization of a vaccinia virus temperature-sensitive complementation group affecting a virion component. Virology. 1991;181:258-72 pubmed..Primer extension analysis also identifies additional late 5' ends which map between nucleotides -500 and -1000 relative to the ORF 18R AUG. ..
- Krishnan A, Nair P, Jones D. Isolation, cloning, and characterization of new chitinase stored in active form in chitin-lined venom reservoir. J Biol Chem. 1994;269:20971-6 pubmed..The kinetic properties of the 52-kDa wasp chitinase were quite distinct from Serratia marcescens chitinase for both catalytic rate and substrate inhibition. ..
- Heinrich J, Ryseck R, Macdonald Bravo H, Bravo R. The product of a novel growth factor-activated gene, fic, is a biologically active "C-C"-type cytokine. Mol Cell Biol. 1993;13:2020-30 pubmed..FIC, muMCP-1, and huMCP-1 competed to the same extent for the binding of [125I]FIC to human monocytes, contrary to huMCP-2, which competed very ineffectively, if at all. ..
- Hall R, Moyer R. Identification of an Amsacta spheroidin-like protein within the occlusion bodies of Choristoneura entomopoxviruses. Virology. 1993;192:179-87 pubmed
- Ohno K, Wang H, Milone M, Bren N, Brengman J, Nakano S, et al. Congenital myasthenic syndrome caused by decreased agonist binding affinity due to a mutation in the acetylcholine receptor epsilon subunit. Neuron. 1996;17:157-70 pubmed..Studies of the engineered epsilon P121L AChR revealed a markedly decreased rate of channel opening, little change in affinity of the resting state for ACh, but reduced affinity of the open channel and desensitized states. ..
- Mehtani S, Gong Q, Panella J, Subbiah S, Peffley D, Frankfater A. In vivo expression of an alternatively spliced human tumor message that encodes a truncated form of cathepsin B. Subcellular distribution of the truncated enzyme in COS cells. J Biol Chem. 1998;273:13236-44 pubmed
- Schmidt P, Dransfield D, Claudio J, Hawley R, Trotter K, Milgram S, et al. AKAP350, a multiply spliced protein kinase A-anchoring protein associated with centrosomes. J Biol Chem. 1999;274:3055-66 pubmed..The localization of AKAP350 suggests that it may regulate centrosomal and noncentrosomal cytoskeletal systems in many different cell types. ..
- Ogura K, Choudhuri S, Klaassen C. Full-length cDNA cloning and genomic organization of the mouse liver-specific organic anion transporter-1 (lst-1). Biochem Biophys Res Commun. 2000;272:563-70 pubmed
- Bai Y, Fox D, Lacy J, Van Lanen S, Iwata Reuyl D. Hypermodification of tRNA in Thermophilic archaea. Cloning, overexpression, and characterization of tRNA-guanine transglycosylase from Methanococcus jannaschii. J Biol Chem. 2000;275:28731-8 pubmed..jannaschii. The nature of the temperature dependence is consistent with a requirement for some degree of tRNA tertiary structure in order for recognition by the enzyme to occur. ..
- Hannah L, Shaw J, Giroux M, Reyss A, Prioul J, Bae J, et al. Maize genes encoding the small subunit of ADP-glucose pyrophosphorylase. Plant Physiol. 2001;127:173-83 pubmed..Finally, whereas barley (Hordeum vulgare) reportedly employs only one gene to encode the small subunit of the seed and leaf, maize utilizes the two genes described here. ..
- Cunningham M, Scarlett J, Steiner R. Cloning and distribution of galanin-like peptide mRNA in the hypothalamus and pituitary of the macaque. Endocrinology. 2002;143:755-63 pubmed publisher..These findings suggest that a leptin-GALP signaling pathway exists in a primate species...
- Takahara K, Schwarze U, Imamura Y, Hoffman G, Toriello H, Smith L, et al. Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-alpha1(V) N-propeptides and Ehlers-Danlos syndrome type I. Am J Hum Genet. 2002;71:451-65 pubmed..These findings suggest that the order of intron removal plays an important role in the outcome of splice-site mutations and provide a model that explains why multiple products derive from a mutation at a single splice site. ..
- Edwards S, Li C, Levy D, Brown J, Snow P, Campbell J. Saccharomyces cerevisiae DNA polymerase epsilon and polymerase sigma interact physically and functionally, suggesting a role for polymerase epsilon in sister chromatid cohesion. Mol Cell Biol. 2003;23:2733-48 pubmed..We also show that trf5 Delta mutants, like trf4 Delta mutants, are defective in DNA repair and sister chromatid cohesion. ..
- Doughman R, Firestone A, Wojtasiak M, Bunce M, Anderson R. Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling. J Biol Chem. 2003;278:23036-45 pubmed..Combined, these data support a model where the localized production of PIP2 by PIPKIalpha is necessary for actin remodeling, whereas formation of membrane ruffles required Rac signaling. ..
- Huang J, Valluzzi R, Bini E, Vernaglia B, Kaplan D. Cloning, expression, and assembly of sericin-like protein. J Biol Chem. 2003;278:46117-23 pubmed..The glue-like property of sericin is attributed to the hydrogen bonding between serine residues of sericin with serine residues in the fibroin structural components of silk fiber. ..
- Gibbs P, McDonald J, Woodgate R, Lawrence C. The relative roles in vivo of Saccharomyces cerevisiae Pol eta, Pol zeta, Rev1 protein and Pol32 in the bypass and mutation induction of an abasic site, T-T (6-4) photoadduct and T-T cis-syn cyclobutane dimer. Genetics. 2005;169:575-82 pubmed..In contrast, bypass of the T-T dimer in the pol32delta strain occurs at the wild-type frequency. ..
- Srinivasan R, Mager G, Ward R, Mayer J, Svaren J. NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex. J Biol Chem. 2006;281:15129-37 pubmed..Finally, we show that interaction with CHD4 is regulated by alternative splicing of the NAB2 mRNA. ..
- Gu R, Zhang Z, Carmichael G. How a small DNA virus uses dsRNA but not RNAi to regulate its life cycle. Cold Spring Harb Symp Quant Biol. 2006;71:293-9 pubmed..Our recent work leads to a model where the production of the multigenomic late RNAs is also controlled by the editing of poly(A) signals, directed by overlapping primary transcripts. ..
- Wickstrum J, Skredenske J, Kolin A, Jin D, Fang J, Egan S. Transcription activation by the DNA-binding domain of the AraC family protein RhaS in the absence of its effector-binding domain. J Bacteriol. 2007;189:4984-93 pubmed..We conclude that RhaS-CTD contains all of the determinants necessary for transcription activation by RhaS. ..
- Ahuja Y, Kohl S, Traboulsi E. CNGA3 mutations in two United Arab Emirates families with achromatopsia. Mol Vis. 2008;14:1293-7 pubmed..We report the responsible mutations in two United Arab Emirates families who have this autosomal recessive disease...
- Kapinas K, Kessler C, Delany A. miR-29 suppression of osteonectin in osteoblasts: regulation during differentiation and by canonical Wnt signaling. J Cell Biochem. 2009;108:216-24 pubmed publisher..Osteonectin and miR-29 are co-expressed in extra-skeletal tissues, and the post-transcriptional mechanisms regulating osteonectin in osteoblasts are likely to be active in other cell systems. ..
- Vyazunova I, Lan Q. Yellow fever mosquito sterol carrier protein-2 gene structure and transcriptional regulation. Insect Mol Biol. 2010;19:205-15 pubmed publisher..This observation leads us to the conclusion that the partnership of transcription factors is crucial in regulating the transcriptional activity of the AeSCP-2 gene. ..
- Rouchka E. Database of exact tandem repeats in the Zebrafish genome. BMC Genomics. 2010;11:347 pubmed publisher..louisville.edu/zebrafish/. This portal allows for users to search for a repeats of a selected base size from any valid specified region within the 25 linkage groups. ..
- Starrett J, Garb J, Kuelbs A, Azubuike U, Hayashi C. Early events in the evolution of spider silk genes. PLoS ONE. 2012;7:e38084 pubmed publisher..We use the spidroin gene tree to reconstruct the evolution of amino acid compositions of spidroins that perform different ecological functions...
- Luo Y, North J, Rose S, Poirier M. Nucleosomes accelerate transcription factor dissociation. Nucleic Acids Res. 2014;42:3017-27 pubmed publisher..Furthermore, these studies demonstrate that nucleosomes regulate DNA-protein interactions not only by preventing DNA-protein binding but by dramatically increasing the dissociation rate of protein complexes from their DNA-binding sites. ..
- Grandy D, Hanneman E, Bunzow J, Shih M, Machida C, Bidlack J, et al. Purification, cloning, and tissue distribution of a 23-kDa rat protein isolated by morphine affinity chromatography. Mol Endocrinol. 1990;4:1370-6 pubmed..Although not an opioid receptor itself, this protein may be associated with such a receptor or be related to a protein that has been shown to be cross-linked to the opioid peptide beta-endorphin. ..
- Shibuya H, Mrad D, Collins B, Stoy S, Nonneman D, Johnson G. Two polymorphisms in the canine beta-A3/A1-crystallin gene, detectable by PCR-RFLP analysis. Anim Genet. 1995;26:284-5 pubmed
- Case S, Cox C, Bell W, Hoffman R, Martin J, Hamilton R. Extraordinary conservation of cysteines among homologous Chironomus silk proteins sp185 and sp220. J Mol Evol. 1997;44:452-62 pubmed..Blockwise sequence comparisons suggest intragenic variation in that some regions evolved slower or faster than the mean and may have been subjected to different selective pressures. ..
- Lee H, Neumann P, Macas J, Jiang J. Transcription and evolutionary dynamics of the centromeric satellite repeat CentO in rice. Mol Biol Evol. 2006;23:2505-20 pubmed..We detected transcripts derived from both strands of the CentO repeats. The CentO transcripts are processed into siRNA, suggesting a potential role of this satellite repeat family in epigenetic chromatin modification. ..
- Maguire K, Kmiec E. Multiple roles for MSH2 in the repair of a deletion mutation directed by modified single-stranded oligonucleotides. Gene. 2007;386:107-14 pubmed..These results reveal that the mechanism of TNE between yeast and mammalian cells is not conserved, and demonstrate that the suppression of the TNE reaction can be bypassed using RNAi against MSH2 designed to knockdown its expression. ..
- Li Y, Zhang Z, Robinson G, Palli S. Identification and characterization of a juvenile hormone response element and its binding proteins. J Biol Chem. 2007;282:37605-17 pubmed
- Chadalavada D, Cerrone Szakal A, Bevilacqua P. Wild-type is the optimal sequence of the HDV ribozyme under cotranscriptional conditions. RNA. 2007;13:2189-201 pubmed..Wild type being the optimal ribozyme sequence under in vivo-like conditions parallels the behavior of most protein enzymes...
- Hou C, Chan N, Gu L, Li G. Incision-dependent and error-free repair of (CAG)(n)/(CTG)(n) hairpins in human cell extracts. Nat Struct Mol Biol. 2009;16:869-75 pubmed publisher..We discuss the implications of these data for understanding the etiology of neurological diseases and trinucleotide repeat instability. ..
- Liu F, Kim Y, Cruickshank C, Theimer C. Thermodynamic characterization of the Saccharomyces cerevisiae telomerase RNA pseudoknot domain in vitro. RNA. 2012;18:973-91 pubmed publisher..Thus, this work provides a detailed in vitro characterization of the thermodynamic features of the S. cerevisiae TLC1 pseudoknot region for comparison with other telomerase RNA pseudoknots. ..
- Paulmichl M, Li Y, Wickman K, Ackerman M, Peralta E, Clapham D. New mammalian chloride channel identified by expression cloning. Nature. 1992;356:238-41 pubmed..The unusual sequence of this putative channel protein suggests a new class of ion channels not related to other previously cloned chloride channels. ..
- Walsh K, Gualberto A. MyoD binds to the guanine tetrad nucleic acid structure. J Biol Chem. 1992;267:13714-8 pubmed..These data are the first report of a direct interaction between a protein and this nucleic acid conformation. The potential biological significance of this finding is discussed. ..
- Lamballe F, Klein R, Barbacid M. trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell. 1991;66:967-79 pubmed..These results indicate that gp145trkC may play an important role in mediating the neurotrophic effects of NT-3. ..
- Sussman M, Setlow P. Cloning, nucleotide sequence, and regulation of the Bacillus subtilis gpr gene, which codes for the protease that initiates degradation of small, acid-soluble proteins during spore germination. J Bacteriol. 1991;173:291-300 pubmed..Induction of sigma G synthesis in vivo turned on gpr-lacZ expression in parallel with synthesis of glucose dehydrogenase. These data are consistent with gpr transcription during sporulation first by E sigma F and then by E sigma G. ..
- Blinkowa A, Walker J. Programmed ribosomal frameshifting generates the Escherichia coli DNA polymerase III gamma subunit from within the tau subunit reading frame. Nucleic Acids Res. 1990;18:1725-9 pubmed
- Green C, Liu W, Kwok S. Cloning and nucleotide sequence analysis of the human beta-microseminoprotein gene. Biochem Biophys Res Commun. 1990;167:1184-90 pubmed..Restriction endonuclease mapping and sequence analysis of this clone revealed the human MSP gene of approximately 15 Kb in length. The gene contains four exons and three large introns of approximately 6, 1, and 7 Kb. ..
- Carrasco D, Bravo R. Tissue-specific expression of the fos-related transcription factor fra-2 during mouse development. Oncogene. 1995;10:1069-79 pubmed..The pattern of fra-2 expression is distinct from that observed for other fos related genes, suggesting that fra-2 has a unique role in cellular differentiation during fetal development. ..
- Brandt U, Yu L, Yu C, Trumpower B. The mitochondrial targeting presequence of the Rieske iron-sulfur protein is processed in a single step after insertion into the cytochrome bc1 complex in mammals and retained as a subunit in the complex. J Biol Chem. 1993;268:8387-90 pubmed..This is apparently the first instance in which a cleaved targeting presequence has been shown to be retained in the cell, possibly exhibiting a second function in addition to its function in protein trafficking. ..
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