Experts and Doctors on base pair mismatch in Italy
Topic: base pair mismatch
Riccardi Sirtori F, Aldini G, Colombo M, Colombo N, Malyszko J, Vistoli G, et al
. Molecular recognition of T:G mismatched base pairs in DNA as studied by electrospray ionization mass spectrometry. ChemMedChem. 2012;7:1112-22 pubmed publisher
..Our results confirm that this ESI method could be a valuable tool for the identification of new molecules able to specifically recognize T:G mismatched base pairs. ..
Nadai M, Palu G, Palumbo M, Richter S. Differential targeting of unpaired bases within duplex DNA by the natural compound clerocidin: a valuable tool to dissect DNA secondary structure. PLoS ONE. 2012;7:e52994 pubmed publisher
..e. 5- and 7-bases) folded or stacked on the duplex region therefore being less accessible by the compound. Clerocidin thus represents a new valuable diagnostic tool to dissect DNA secondary structures. ..
Castrilli G, Piantelli M, Artese L, Perfetti G, Rubini C, Fioroni M, et al
. Expression of hMSH2 and hMLH1 proteins of the human DNA mismatch repair system in ameloblastoma. J Oral Pathol Med. 2001;30:305-8 pubmed
..The localization of the staining was exclusively nuclear. These data suggest that the development and progression of these tumors do not depend on a defect in the hMMR system. ..
Losi L, Di Gregorio C, Pedroni M, Ponti G, Roncucci L, Scarselli A, et al
. Molecular genetic alterations and clinical features in early-onset colorectal carcinomas and their role for the recognition of hereditary cancer syndromes. Am J Gastroenterol. 2005;100:2280-7 pubmed
..These results suggest that patients with early-onset CRC should be screened for hereditary cancer syndrome through clinical and molecular characterizations. ..
Gratton P, Konopiński M, Sbordoni V. Pleistocene evolutionary history of the Clouded Apollo (Parnassius mnemosyne): genetic signatures of climate cycles and a 'time-dependent' mitochondrial substitution rate. Mol Ecol. 2008;17:4248-62 pubmed publisher
..19 000 years before present (last glacial maximum), and parameters of demographic expansion for northern lineages are consistent with postglacial warming (5-11 000 years before present). ..
Laghi L, Ranzani G, Bianchi P, Mori A, Heinimann K, Orbetegli O, et al
. Frameshift mutations of human gastrin receptor gene (hGARE) in gastrointestinal cancers with microsatellite instability. Lab Invest. 2002;82:265-71 pubmed
..Functional studies are warranted to elucidate the mechanism by which the hGARE mutation might contribute to gastrointestinal carcinogenesis. ..
Agostini M, Pulciarelli S, Pucciarelli S, Bertorelle R, Calandra P, Villani F, et al
. Genetic heterogeneity of variable number tandem repeats in thymidylate synthase gene in colorectal cancer patients. Int J Biol Markers. 2004;19:332-6 pubmed
Ciavattini A, Piccioni M, Tranquilli A, Filosa A, Pieramici T, Goteri G. Immunohistochemical expression of DNA mismatch repair (MMR) system proteins (hMLH1, hMSH2) in cervical preinvasive and invasive lesions. Pathol Res Pract. 2005;201:21-5 pubmed
..0001). Preinvasive lesions showed increased expression of both proteins if compared with normal esocervical epithelium. Neoplastic stromal invasiveness is associated with a significant loss of hMLH1 function. ..
Pastrello C, Santarosa M, Fornasarig M, Sigon R, Perin T, Giannini G, et al
. MUC gene abnormalities in sporadic and hereditary mucinous colon cancers with microsatellite instability. Dis Markers. 2005;21:121-6 pubmed