Genomes and Genes
Experts and Doctors on bacterial proteins in United States
Locale: United States
Topic: bacterial proteins
Publications927 found, 100 shown here
- Chong P, Drake L, Biswas I. Modulation of covR expression in Streptococcus mutans UA159. J Bacteriol. 2008;190:4478-88 pubmed publisher..A detailed analysis of the regulation of CovR may lead to a better understanding of the pathogenesis of S. mutans, as well as providing further insight into the prevention of dental caries. ..
- Huang Y, Xun R, Chen G, Xun L. Maintenance role of a glutathionyl-hydroquinone lyase (PcpF) in pentachlorophenol degradation by Sphingobium chlorophenolicum ATCC 39723. J Bacteriol. 2008;190:7595-600 pubmed publisher..Thus, PcpF played a maintenance role in PCP degradation and converted the GS-hydroquinone conjugates back to the intermediates of the PCP degradation pathway...
- Hernandez J, George S, Rubio L. Molybdenum trafficking for nitrogen fixation. Biochemistry. 2009;48:9711-21 pubmed publisher..Molybdenum biochemistry in A. vinelandii reveals unexpected mechanisms and a new role for iron-sulfur clusters in the sequestration and delivery of molybdenum. ..
- Chattoraj P, Banerjee A, Biswas S, Biswas I. ClpP of Streptococcus mutans differentially regulates expression of genomic islands, mutacin production, and antibiotic tolerance. J Bacteriol. 2010;192:1312-23 pubmed publisher..The results presented here indicate that ClpP-mediated proteolysis plays an important global role in the regulation of several important traits in this pathogen. ..
- Amachawadi R, Shelton N, Shi X, Vinasco J, Dritz S, Tokach M, et al. Selection of fecal enterococci exhibiting tcrB-mediated copper resistance in pigs fed diets supplemented with copper. Appl Environ Microbiol. 2011;77:5597-603 pubmed publisher..faecalis strains. The higher prevalence of tcrB-positive enterococci in piglets fed elevated copper compared to that in piglets fed normal copper suggests that supplementation of copper in swine diets selected for resistance. ..
- Daily M, Phillips G, Cui Q. Interconversion of functional motions between mesophilic and thermophilic adenylate kinases. PLoS Comput Biol. 2011;7:e1002103 pubmed publisher..This mutational framework can inform the rational design of functionally important flexibility and allostery in other proteins toward engineering novel biochemical pathways. ..
- Côté G, Skory C. Cloning, expression, and characterization of an insoluble glucan-producing glucansucrase from Leuconostoc mesenteroides NRRL B-1118. Appl Microbiol Biotechnol. 2012;93:2387-94 pubmed publisher..NMR and methylation analysis of the water-insoluble ?-D-glucan revealed that it had approximately equal amounts of ?(1 ? 3)-linked and ?(1 ? 6)-linked D-glucopyranosyl units and a low degree of branching. ..
- Lambrecht J, Flynn J, Downs D. Conserved YjgF protein family deaminates reactive enamine/imine intermediates of pyridoxal 5'-phosphate (PLP)-dependent enzyme reactions. J Biol Chem. 2012;287:3454-61 pubmed publisher..The conservation of the RidA/YjgF family suggests that reactive enamine/imine metabolites are of concern to all organisms...
- Butzin X, Troiano A, Coleman W, Griffiths K, Doona C, Feeherry F, et al. Analysis of the effects of a gerP mutation on the germination of spores of Bacillus subtilis. J Bacteriol. 2012;194:5749-58 pubmed publisher..All these results support the suggestion that GerP proteins facilitate access of nutrient germinants to their cognate GRs in spores' inner membrane. ..
- Zeng L, Burne R. Comprehensive mutational analysis of sucrose-metabolizing pathways in Streptococcus mutans reveals novel roles for the sucrose phosphotransferase system permease. J Bacteriol. 2013;195:833-43 pubmed publisher..Sucrose-dependent catabolite repression was also evident in strains containing an intact sucrose PTS. Collectively, these results reveal a novel regulatory circuitry for the control of sucrose catabolism, with a central role for ScrA...
- Young J, Locke J, Elowitz M. Rate of environmental change determines stress response specificity. Proc Natl Acad Sci U S A. 2013;110:4140-5 pubmed publisher..Such dynamic control of specificity could be a critical function of other general stress response pathways. ..
- Palmer G, Jorth P, Whiteley M. The role of two Pseudomonas aeruginosa anthranilate synthases in tryptophan and quorum signal production. Microbiology. 2013;159:959-69 pubmed publisher..aeruginosa trpEG mutant. Based on these data, we propose a model for anthranilate sequestration by differential transcriptional regulation of the two P. aeruginosa anthranilate synthase enzymes. ..
- Westerhold L, Bridges L, Shaikh S, Zeczycki T. Kinetic and Thermodynamic Analysis of Acetyl-CoA Activation of Staphylococcus aureus Pyruvate Carboxylase. Biochemistry. 2017;56:3492-3506 pubmed publisher..Taken together, our kinetic and thermodynamic results provide a possible allosteric mechanism by which acetyl-CoA coordinates catalysis within the PC tetramer. ..
- Liang F, Nowling J, Philipp M. Cryptic and exposed invariable regions of VlsE, the variable surface antigen of Borrelia burgdorferi sl. J Bacteriol. 2000;182:3597-601 pubmed..However, negative surface immunofluorescence and in vitro antibody-mediated killing results indicated that none of the IRs were accessible to antibody at the spirochetal surface in vitro. ..
- Vesey P, Kuramitsu H. Genetic analysis of Treponema denticola ATCC 35405 biofilm formation. Microbiology. 2004;150:2401-7 pubmed..In contrast, T. denticola lacking the PrtP protein for prolyl-phenylalanine-specific protease, showed an increased ability to form mixed biofilms and a prolonged viability in the biofilm...
- Mason K, Munson R, Bakaletz L. A mutation in the sap operon attenuates survival of nontypeable Haemophilus influenzae in a chinchilla model of otitis media. Infect Immun. 2005;73:599-608 pubmed..Our results indicate that the products of the sap operon are important for resisting the activity of APs and may regulate, in part, the balance between normal carriage and disease caused by NTHI...
- Suprenant K, Bloom N, Fang J, Lushington G. The major vault protein is related to the toxic anion resistance protein (TelA) family. J Exp Biol. 2007;210:946-55 pubmed publisher..In addition, vaultosomes form independently from other stress-induced ribonucleoprotein complexes, stress granules and aggresomes. Vaultosome formation is therefore a unique cellular response to an environmental toxin...
- Al Khodor S, Price C, Kalia A, Abu Kwaik Y. Functional diversity of ankyrin repeats in microbial proteins. Trends Microbiol. 2010;18:132-9 pubmed publisher..Studying the molecular and biochemical functions of this family of proteins will enhance our understanding of important host-microbe interactions. ..
- Lee P, Stopford C, Svenson A, Rietsch A. Control of effector export by the Pseudomonas aeruginosa type III secretion proteins PcrG and PcrV. Mol Microbiol. 2010;75:924-41 pubmed publisher..Taken together, these data allow us to propose a working model for control of effector secretion by PcrG and PcrV...
- Shen B, Lutkenhaus J. Differences in MinC/MinD sensitivity between polar and internal Z rings in Escherichia coli. J Bacteriol. 2011;193:367-76 pubmed publisher..Taken together, these data indicate that polar Z rings are more susceptible to MinC/MinD than internal Z rings, even when MinE is absent. ..
- Wilson R, Kumar P, Parashar V, VilchÃ¨ze C, Veyron Churlet R, Freundlich J, et al. Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis. Nat Chem Biol. 2013;9:499-506 pubmed publisher..tuberculosis Pks13 is required for mycolic acid biosynthesis, validates it as a druggable target and demonstrates the therapeutic potential of simultaneously inhibiting multiple targets in the same biosynthetic pathway. ..
- Dombroski A, Walter W, Record M, Siegele D, Gross C. Polypeptides containing highly conserved regions of transcription initiation factor sigma 70 exhibit specificity of binding to promoter DNA. Cell. 1992;70:501-12 pubmed..Thus, we propose that sigma 70 is a sequence-specific DNA-binding protein that normally functions through an allosteric interaction with the core subunits of RNA polymerase. ..
- Plano G, Barve S, Straley S. LcrD, a membrane-bound regulator of the Yersinia pestis low-calcium response. J Bacteriol. 1991;173:7293-303 pubmed..The alkaline phosphatase activities of the resultant hybrid proteins were consistent with a model predicting eight amino-terminal transmembrane segments that anchor a large cytoplasmic carboxyl-terminal domain to the inner membrane...
- Palenchar P, Buck C, Cheng H, Larson T, Mueller E. Evidence that ThiI, an enzyme shared between thiamin and 4-thiouridine biosynthesis, may be a sulfurtransferase that proceeds through a persulfide intermediate. J Biol Chem. 2000;275:8283-6 pubmed..To accommodate this hypothesis, we propose a general mechanism for sulfur transfer in which the terminal sulfur of the persulfide first acts as a nucleophile and is then transferred as an equivalent of S(2-) rather than S(0). ..
- Kielian T, Cheung A, Hickey W. Diminished virulence of an alpha-toxin mutant of Staphylococcus aureus in experimental brain abscesses. Infect Immun. 2001;69:6902-11 pubmed..aureus intracellularly, providing a means by which the organism may establish chronic infections in the brain. Together, these data identify alpha-toxin as a key virulence determinant for the survival of S. aureus in the brain. ..
- Mehta S, Yang X, Chan C, Dobson M, Jayaram M, Velmurugan S. The 2 micron plasmid purloins the yeast cohesin complex: a mechanism for coupling plasmid partitioning and chromosome segregation?. J Cell Biol. 2002;158:625-37 pubmed..Cohesin-mediated pairing and unpairing likely provides a counting mechanism for evenly partitioning plasmids either in association with or independently of the chromosomes. ..
- Ingavale S, van Wamel W, Cheung A. Characterization of RAT, an autolysis regulator in Staphylococcus aureus. Mol Microbiol. 2003;48:1451-66 pubmed..As anticipated, rat appears to be a negative regulator of autolysin genes including lytM and lytN. These data suggest that the rat gene product is an important regulator of autolytic activity in S. aureus...
- Matthews M, Periyannan G, Hajdin C, Sidgel T, Bennett B, Crowder M. Probing the reaction mechanism of the D-ala-D-ala dipeptidase, VanX, by using stopped-flow kinetic and rapid-freeze quench EPR studies on the Co(II)-substituted enzyme. J Am Chem Soc. 2006;128:13050-1 pubmed..The EPR studies also identified a distinct enzyme product complex. The results were used to offer a detailed reaction mechanism for VanX that can be used to guide future inhibitor design efforts. ..
- Edwards J. Neisseria gonorrhoeae survival during primary human cervical epithelial cell infection requires nitric oxide and is augmented by progesterone. Infect Immun. 2010;78:1202-13 pubmed publisher..In addition, these data demonstrate that host-derived nitric oxide likely is not protective against gonococci, in vivo; rather, nitric oxide may be required to sustain cervical bacterial disease. ..
- Perez F, Pultz M, Endimiani A, Bonomo R, Donskey C. Effect of antibiotic treatment on establishment and elimination of intestinal colonization by KPC-producing Klebsiella pneumoniae in mice. Antimicrob Agents Chemother. 2011;55:2585-9 pubmed publisher..The administration of nonabsorbed oral antibiotics may be an effective strategy to suppress colonization with KPC-Kp. ..
- Callahan B, Topilina N, Stanger M, Van Roey P, Belfort M. Structure of catalytically competent intein caught in a redox trap with functional and evolutionary implications. Nat Struct Mol Biol. 2011;18:630-3 pubmed publisher..A natural analog of the designed system was identified in Pyrococcus abyssi, suggesting an unprecedented form of adaptive, post-translational regulation. ..
- El Gazzar M, Wetzel A, Raviv Z. The genotyping potential of the Mycoplasma synoviae vlhA gene. Avian Dis. 2012;56:711-9 pubmed..In addition, this study allows interesting insight into the gene conversion mechanism of MS and offers the opportunity for further investigation this mechanism in mycoplasmas...
- Bannantine J, Lingle C, Adam P, Ramyar K, McWhorter W, Stabel J, et al. NlpC/P60 domain-containing proteins of Mycobacterium avium subspecies paratuberculosis that differentially bind and hydrolyze peptidoglycan. Protein Sci. 2016;25:840-51 pubmed publisher..Collectively, these findings suggest a broader functional repertoire for NlpC/P60 domain-containing proteins than simply hydrolases. ..
- Rosey E, Stewart G. Nucleotide and deduced amino acid sequences of the lacR, lacABCD, and lacFE genes encoding the repressor, tagatose 6-phosphate gene cluster, and sugar-specific phosphotransferase system components of the lactose operon of Streptococcus mutans. J Bacteriol. 1992;174:6159-70 pubmed..mutans lac promoter appears to contain repeat elements analogous to those of S. aureus, suggesting that repression and catabolite repression of the lactose operons may be similar in these organisms...
- Tabassum R, Sandman K, Reeve J. HMt, a histone-related protein from Methanobacterium thermoautotrophicum delta H. J Bacteriol. 1992;174:7890-5 pubmed..Histone-related proteins with these properties are therefore not limited to reverse gyrase-containing hyperthermophilic species. ..
- Wu J, Newton A. Isolation, identification, and transcriptional specificity of the heat shock sigma factor sigma32 from Caulobacter crescentus. J Bacteriol. 1996;178:2094-101 pubmed..crescentus sigma32 appear to be very similar to those of its E. coli counterpart, the C. crescentus rpoH gene contains a novel promoter structure and may be positively autoregulated in response to environmental stress. ..
- Nakano M. Induction of ResDE-dependent gene expression in Bacillus subtilis in response to nitric oxide and nitrosative stress. J Bacteriol. 2002;184:1783-7 pubmed..Among members of the ResDE regulon, only the flavohemoglobin gene was induced by nitrosative stress via both a ResDE-dependent mechanism and an unidentified ResDE-independent mechanism. ..
- Dong Y, Chen Y, Snyder J, Burne R. Isolation and molecular analysis of the gene cluster for the arginine deiminase system from Streptococcus gordonii DL1. Appl Environ Microbiol. 2002;68:5549-53 pubmed..Thus, ArcR is a transcriptional activator that is required for induction and optimal expression of the S. gordonii ADS gene cluster...
- González E, Allen C. Characterization of a Ralstonia solanacearum operon required for polygalacturonate degradation and uptake of galacturonic acid. Mol Plant Microbe Interact. 2003;16:536-44 pubmed..This exuT mutant had wild-type virulence on tomato, demonstrating that metabolism of galacturonic acid does not contribute significantly to bacterial success inside the plant...
- Newberry K, Brennan R. The structural mechanism for transcription activation by MerR family member multidrug transporter activation, N terminus. J Biol Chem. 2004;279:20356-62 pubmed..Analysis of the structures of BmrR, CueR, and ZntR indicates that this hinge may be common to all MerR family members. ..
- Tans Kersten J, Brown D, Allen C. Swimming motility, a virulence trait of Ralstonia solanacearum, is regulated by FlhDC and the plant host environment. Mol Plant Microbe Interact. 2004;17:686-95 pubmed..Thus, expression of flhDC and flagellin itself are uncoupled from bacterial motility in the host environment, indicating that additional signals and regulatory circuits repress motility during plant pathogenesis...
- Jilaveanu L, Zito C, Oliver D. Dimeric SecA is essential for protein translocation. Proc Natl Acad Sci U S A. 2005;102:7511-6 pubmed..Our findings have important implications regarding SecA motor function and translocon assembly and activation. ..
- Zhang P, Martin M, Michalek S, Katz J. Role of mitogen-activated protein kinases and NF-kappaB in the regulation of proinflammatory and anti-inflammatory cytokines by Porphyromonas gingivalis hemagglutinin B. Infect Immun. 2005;73:3990-8 pubmed..Taken together, our results demonstrate a role for the p38 and ERK pathways and the transcription factor NF-kappaB in modulating key immunoregulatory cytokines involved in the development of immune responses to P. gingivalis HagB. ..
- Robert Seilaniantz A, Shan L, Zhou J, Tang X. The Pseudomonas syringae pv. tomato DC3000 type III effector HopF2 has a putative myristoylation site required for its avirulence and virulence functions. Mol Plant Microbe Interact. 2006;19:130-8 pubmed..HopF2 contains a putative myristoylation site. Mutational analysis indicated that this site is required for plasma membrane localization and virulence and avirulence activities of HopF2. ..
- Dajkovic A, Mukherjee A, Lutkenhaus J. Investigation of regulation of FtsZ assembly by SulA and development of a model for FtsZ polymerization. J Bacteriol. 2008;190:2513-26 pubmed publisher..In vivo stoichiometry of the disruption of Z rings by SulA suggests that FtsZ may undergo two cooperative transitions in forming the Z ring. ..
- Hayden J, Ades S. The extracytoplasmic stress factor, sigmaE, is required to maintain cell envelope integrity in Escherichia coli. PLoS ONE. 2008;3:e1573 pubmed publisher..Our results are consistent with a model in which overexpression of ptsN reduces stress in the cell envelope, thereby promoting survival in the absence of sigma(E). ..
- Rentmeister A, Arnold F, Fasan R. Chemo-enzymatic fluorination of unactivated organic compounds. Nat Chem Biol. 2009;5:26-8 pubmed publisher..This procedure was applied for the rapid identification of fluorinated drug derivatives with enhanced membrane permeability. ..
- Konkel M, Larson C, Flanagan R. Campylobacter jejuni FlpA binds fibronectin and is required for maximal host cell adherence. J Bacteriol. 2010;192:68-76 pubmed publisher..Based on these data, we conclude that FlpA mediates C. jejuni attachment to host epithelial cells via Fn binding. ..
- Greenwell R, Nam T, Donohue T. Features of Rhodobacter sphaeroides ChrR required for stimuli to promote the dissociation of ?(E)/ChrR complexes. J Mol Biol. 2011;407:477-91 pubmed publisher..Finally, we found that the same aspects of R. sphaeroides ChrR needed for a response to (1)O(2) are required for the dissociation of ?(E)/ChrR complexes in the presence of the organic hydroperoxide t-butyl hydroperoxide...
- Jahn C, Selimi D, Barak J, Charkowski A. The Dickeya dadantii biofilm matrix consists of cellulose nanofibres, and is an emergent property dependent upon the type III secretion system and the cellulose synthesis operon. Microbiology. 2011;157:2733-44 pubmed publisher..Mutation of the cellulose synthase bcsA or of bcsC resulted in decreased accumulation of the T3SS-secreted protein HrpN. ..
- Lee Y, Mick J, Furdui C, Beamer L. A coevolutionary residue network at the site of a functionally important conformational change in a phosphohexomutase enzyme family. PLoS ONE. 2012;7:e38114 pubmed publisher..This work adds to our understanding of the functional roles of coevolving residue networks, and has implications for the definition of catalytically important residues. ..
- Hemarajata P, Yang S, Soge O, Humphries R, Klausner J. Performance and Verification of a Real-Time PCR Assay Targeting the gyrA Gene for Prediction of Ciprofloxacin Resistance in Neisseria gonorrhoeae. J Clin Microbiol. 2016;54:805-8 pubmed publisher..Among 76 clinical urine and swab specimens positive for N. gonorrhoeae by the Cobas assay, 71% could be genotyped. The test took 1.5 h to perform, allowing the physician to receive results in time to make informed clinical decisions. ..
- Ford N, Hecht K, Hu D, Orr G, Xiong Y, Squier T, et al. Antigen Binding and Site-Directed Labeling of Biosilica-Immobilized Fusion Proteins Expressed in Diatoms. ACS Synth Biol. 2016;5:193-9 pubmed publisher..In conclusion, our results demonstrate an ability to engineer diatoms to create antibody-functionalized mesoporous silica able to selectively bind chemical and biological agents for the development of sensing platforms. ..
- Chilton S, Falbel T, Hromada S, Burton B. A Conserved Metal Binding Motif in the Bacillus subtilis Competence Protein ComFA Enhances Transformation. J Bacteriol. 2017;199: pubmed publisher..We demonstrate that several amino acid motifs conserved among ComFA proteins are important for efficient transformation. This report is the first to demonstrate the functional requirement of an amino-terminal cysteine motif in ComFA. ..
- Ebel W, Trempy J. Escherichia coli RcsA, a positive activator of colanic acid capsular polysaccharide synthesis, functions To activate its own expression. J Bacteriol. 1999;181:577-84 pubmed..coli cps promoter and the Erwinia amylovora ams promoter and previously shown to be the RcsA-RcsB binding site, was identified in the rcsA promoter region and shown to be required for high-level expression of rcsA. ..
- Carlos J, Paetzel M, Brubaker G, Karla A, Ashwell C, Lively M, et al. The role of the membrane-spanning domain of type I signal peptidases in substrate cleavage site selection. J Biol Chem. 2000;275:38813-22 pubmed..In contrast, certain mutants in the c-region of the signal peptide result in alternate site cleavage by both Lep and SipS enzymes...
- Swem L, Elsen S, Bird T, Swem D, Koch H, Myllykallio H, et al. The RegB/RegA two-component regulatory system controls synthesis of photosynthesis and respiratory electron transfer components in Rhodobacter capsulatus. J Mol Biol. 2001;309:121-38 pubmed..These data provide evidence that the RegB/RegA two-component system has a major role in controlling the synthesis of numerous processes that affect reducing equivalents in Rhodobacter capsulatus...
- Rajagopalan P, Lutz S, Benkovic S. Coupling interactions of distal residues enhance dihydrofolate reductase catalysis: mutational effects on hydride transfer rates. Biochemistry. 2002;41:12618-28 pubmed..Natl. Acad. Sci. U.S.A. 99, 2794-2799], the data suggest that a coupled dynamic motion of these distal residues enhances crossing of the chemical reaction barrier and imply an expanded nonstatic role for the protein fold in catalysis. ..
- Geller B, Deere J, Stein D, Kroeker A, Moulton H, Iversen P. Inhibition of gene expression in Escherichia coli by antisense phosphorodiamidate morpholino oligomers. Antimicrob Agents Chemother. 2003;47:3233-9 pubmed..We conclude that the outer membrane of E. coli inhibits entry of PMOs and that (KFF)(3)KC-PMO conjugates are transported across both membranes and specifically inhibit expression of their genetic targets. ..
- Gong X, Yu L, Xia D, Yu C. Evidence for electron equilibrium between the two hemes bL in the dimeric cytochrome bc1 complex. J Biol Chem. 2005;280:9251-7 pubmed..This supports the idea that the interruption of electron transfer between the two bL hemes enhances electron leakage to oxygen and thus decreases the ubiquinol-cytochrome c reductase activity. ..
- Tsenova L, Harbacheuski R, Moreira A, Ellison E, Dalemans W, Alderson M, et al. Evaluation of the Mtb72F polyprotein vaccine in a rabbit model of tuberculous meningitis. Infect Immun. 2006;74:2392-401 pubmed..Interestingly, Mtb72F+AS01B induced better protection against leukocytosis and weight loss, suggesting that the polyprotein in this adjuvant may boost immunity without exacerbating inflammation in previously BCG-vaccinated individuals. ..
- He X, Thornton J, Carmicle Davis S, McDaniel L. Tex, a putative transcriptional accessory factor, is involved in pathogen fitness in Streptococcus pneumoniae. Microb Pathog. 2006;41:199-206 pubmed..The interaction between recombinant Tex and nucleic acids was confirmed by southwestern and northwestern analysis, supporting its role as a transcriptional accessory factor. ..
- Running W, Ravipaty S, Karty J, Reilly J. A top-down/bottom-up study of the ribosomal proteins of Caulobacter crescentus. J Proteome Res. 2007;6:337-47 pubmed
- Purdy G, Fisher C, Payne S. IcsA surface presentation in Shigella flexneri requires the periplasmic chaperones DegP, Skp, and SurA. J Bacteriol. 2007;189:5566-73 pubmed..Therefore, the three periplasmic folding factors DegP, Skp, and SurA were all required for IcsA localization and plaque formation by S. flexneri. ..
- Colangeli R, Helb D, Vilcheze C, Hazbón M, Lee C, Safi H, et al. Transcriptional regulation of multi-drug tolerance and antibiotic-induced responses by the histone-like protein Lsr2 in M. tuberculosis. PLoS Pathog. 2007;3:e87 pubmed..An improved understanding of the role of lsr2 may provide important insights into the mechanisms of action of antibiotics and the way that mycobacteria adapt to stresses such as antibiotic treatment. ..
- Ayala Castro C, Saini A, Outten F. Fe-S cluster assembly pathways in bacteria. Microbiol Mol Biol Rev. 2008;72:110-25, table of contents pubmed publisher..Here we attempt to summarize recent advances and to highlight new avenues of research in the field of Fe-S cluster assembly. ..
- Rice L, Lakticova V, Carias L, Rudin S, Hutton R, Marshall S. Transferable capacity for gastrointestinal colonization in Enterococcus faecium in a mouse model. J Infect Dis. 2009;199:342-9 pubmed publisher..These results indicate that E. faecium clinical isolates express transmissible factors other than antimicrobial resistance that promote colonization of the mouse gastrointestinal tract. ..
- Smith T, Hoover T. Deciphering bacterial flagellar gene regulatory networks in the genomic era. Adv Appl Microbiol. 2009;67:257-95 pubmed publisher..Finally, we review the prominent systems that utilize sigma(28) and its antagonist, the anti-sigma(28) factor FlgM, along with some systems that utilize alternative mechanisms for regulating flagellar gene expression. ..
- Zhang Y, Pohlmann E, Serate J, Conrad M, Roberts G. Mutagenesis and functional characterization of the four domains of GlnD, a bifunctional nitrogen sensor protein. J Bacteriol. 2010;192:2711-21 pubmed publisher..The deletion of C-terminal ACT domains also dramatically decreased UTase activity under all conditions tested, but some of these effects are due to the competition of UTase activity with unregulated UR activity in these variants...
- Drage M, Tsai H, Pecora N, Cheng T, Arida A, Shukla S, et al. Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2. Nat Struct Mol Biol. 2010;17:1088-95 pubmed publisher..In conclusion, we demonstrate a glycolipid binding function of LprG that enhances recognition of triacylated MTB glycolipids by TLR2 and may affect glycolipid assembly or transport for bacterial cell wall biogenesis. ..
- Zou W, Al Khaldi S, Branham W, Han T, Fuscoe J, Han J, et al. Microarray analysis of virulence gene profiles in Salmonella serovars from food/food animal environment. J Infect Dev Ctries. 2011;5:94-105 pubmed..This hybridization array presents an accurate and cost-effective method for evaluating the disease-causing potential of Salmonella in outbreak investigations by targeting a selective set of Salmonella-associated virulence genes. ..
- Rathod R, Kang Z, Hartson S, Kumauchi M, Xie A, Hoff W. Side-chain specific isotopic labeling of proteins for infrared structural biology: the case of ring-D4-tyrosine isotope labeling of photoactive yellow protein. Protein Expr Purif. 2012;85:125-32 pubmed publisher..The results described here open the way to the analysis of PYP using isotope-edited FTIR spectroscopy with side-chain specific labeling. ..
- Tattersall J, Rao G, Runac J, Hackstadt T, Grieshaber S, Grieshaber N. Translation inhibition of the developmental cycle protein HctA by the small RNA IhtA is conserved across Chlamydia. PLoS ONE. 2012;7:e47439 pubmed publisher..As biolayer interferometry studies indicate that IhtA interacts directly with hctA message for all species tested, we predict that conserved sequences of IhtA are necessary for function and/or binding...
- Lyell N, Colton D, Bose J, Tumen Velasquez M, Kimbrough J, Stabb E. Cyclic AMP receptor protein regulates pheromone-mediated bioluminescence at multiple levels in Vibrio fischeri ES114. J Bacteriol. 2013;195:5051-63 pubmed publisher..Second, the effect of CRP on the ainS promoter depended on whether the V. fischeri regulatory gene litR was also introduced. These results suggest an integral role for CRP in pheromone signaling that goes beyond sensing cell density. ..
- Zimmerman S, Dyke J, Jelesijevic T, Michel F, Lafontaine E, Hogan R. Antibodies against In Vivo-Expressed Antigens Are Sufficient To Protect against Lethal Aerosol Infection with Burkholderia mallei and Burkholderia pseudomallei. Infect Immun. 2017;85: pubmed publisher..mallei and B. pseudomallei, including antigen discovery. ..
- Hasona A, Self W, Ray R, Shanmugam K. Molybdate-dependent transcription of hyc and nar operons of Escherichia coli requires MoeA protein and ModE-molybdate. FEMS Microbiol Lett. 1998;169:111-6 pubmed..It is proposed that the MoeA-catalyzed product, an activated form of molybdate, interacts with a transcriptional activator/regulator other than ModE and regulates hyc and nar operons. ..
- Hale C, de Boer P. Recruitment of ZipA to the septal ring of Escherichia coli is dependent on FtsZ and independent of FtsA. J Bacteriol. 1999;181:167-76 pubmed..It is suggested that septal ring formation starts by assembly of the FtsZ ring, after which ZipA and FtsA join this structure in a mutually independent fashion through direct interactions with the FtsZ protein. ..
- Bozue J, Tullius M, Wang J, Gibson B, Munson R. Haemophilus ducreyi produces a novel sialyltransferase. Identification of the sialyltransferase gene and construction of mutants deficient in the production of the sialic acid-containing glycoform of the lipooligosaccharide. J Biol Chem. 1999;274:4106-14 pubmed..We conclude that the lst gene encodes the H. ducreyi sialyltransferase. Since the lst gene product has little, if any, structural relationship to other sialyltransferases, this protein represents a new class of sialyltransferase...
- Xun L, Bohuslavek J, Cai M. Characterization of 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA) of Sphingomonas chlorophenolica ATCC 39723. Biochem Biophys Res Commun. 1999;266:322-5 pubmed publisher..On the basis of the reaction stoichiometry, the enzyme is proposed to be 2,6-DiCH 1,2-dioxygenase...
- Preston K, Radomski C, Venezia R. Nucleotide sequence of a 7-kb fragment of pACM1 encoding an IncM DNA primase and other putative proteins associated with conjugation. Plasmid. 2000;44:12-23 pubmed..Therefore, primase function can be assigned to PriL. Fragment 90/91 represents a portion of the IncM tra region, which has not previously been examined in detail. ..
- Rocha E, Owens G, Smith C. The redox-sensitive transcriptional activator OxyR regulates the peroxide response regulon in the obligate anaerobe Bacteroides fragilis. J Bacteriol. 2000;182:5059-69 pubmed..Analysis of oxyR expression in the parents and in DeltaoxyR and overexpressing oxyR strains by Northern blotting and oxyR'::xylB fusions revealed that B. fragilis OxyR does not control its own expression...
- Brown S, Parrish J, Denell R, Beeman R. Genetic control of early embryogenesis in the red flour beetle, Tribolium castaneum. Am Zool. 1994;34:343-52 pubmed..Nevertheless, differences between Tribolium and Drosophila in the dynamics of even-skipped expression and the fushi tarazu mutant phenotype indicate divergence in the regulation and roles of these genes. ..
- Freeman J, Rappl C, Kuhle V, Hensel M, Miller S. SpiC is required for translocation of Salmonella pathogenicity island 2 effectors and secretion of translocon proteins SseB and SseC. J Bacteriol. 2002;184:4971-80 pubmed..SpiC was also required to secrete translocon proteins SseB and SseC but not translocated effector SseJ, indicating that lack of assembly of the translocon explains the spiC mutant phenotype. ..
- Ashfield T, Ong L, Nobuta K, Schneider C, Innes R. Convergent evolution of disease resistance gene specificity in two flowering plant families. Plant Cell. 2004;16:309-18 pubmed..We conclude that convergent evolution, rather than the conservation of an ancient specificity, is responsible for the generation of these AvrB-specific genes. ..
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