Genomes and Genes
Experts and Doctors on bacterial gene expression regulation in United States
Locale: United States
Topic: bacterial gene expression regulation
Publications193 found, 100 shown here
- Lawler M, Larson D, Hinz A, Klein D, Brun Y. Dissection of functional domains of the polar localization factor PodJ in Caulobacter crescentus. Mol Microbiol. 2006;59:301-16 pubmed..Finally, we identify a cytoplasmic region of PodJ involved in targeting it to the flagellar pole, and a periplasmic region required for localization of PleC. ..
- Diodati M, Ossa F, Caberoy N, Jose I, Hiraiwa W, Igo M, et al. Nla18, a key regulatory protein required for normal growth and development of Myxococcus xanthus. J Bacteriol. 2006;188:1733-43 pubmed..Our data are consistent with a model in which Nla18 controls vegetative growth and development by activating the expression of genes involved in gene regulation, translation, and membrane structure. ..
- Brown S, Thompson M, Verberkmoes N, Chourey K, Shah M, Zhou J, et al. Molecular dynamics of the Shewanella oneidensis response to chromate stress. Mol Cell Proteomics. 2006;5:1054-71 pubmed
- Yang J, Sangwan I, O Brian M. The Bradyrhizobium japonicum Fur protein is an iron-responsive regulator in vivo. Mol Genet Genomics. 2006;276:555-64 pubmed publisher..The findings show that B. japonicum Fur is involved in iron-dependent gene expression, and support the conclusion that rhizobial Fur proteins have novel functions compared with well studied model systems...
- Teplitski M, Al Agely A, Ahmer B. Contribution of the SirA regulon to biofilm formation in Salmonella enterica serovar Typhimurium. Microbiology. 2006;152:3411-24 pubmed..In turn, csrB and csrC promote the translation of the fim operon, while at the same time inhibiting the translation of flagella, which are inhibitory to biofilm formation. ..
- Sohanpal B, Friar S, Roobol J, Plumbridge J, Blomfield I. Multiple co-regulatory elements and IHF are necessary for the control of fimB expression in response to sialic acid and N-acetylglucosamine in Escherichia coli K-12. Mol Microbiol. 2007;63:1223-36 pubmed..These results support a refined model for how two potentially key indicators of host inflammation, Neu(5)Ac and GlcNAc, regulate type 1 fimbriation. ..
- Wang X, Kikuchi T, Rikihisa Y. Proteomic identification of a novel Anaplasma phagocytophilum DNA binding protein that regulates a putative transcription factor. J Bacteriol. 2007;189:4880-6 pubmed..Addition of regions I, II, and III did not enhance transactivation. These results show that ApxR is a novel transcriptional regulator that directly regulates tr1. ..
- Kyzer S, Ha K, Landick R, Palangat M. Direct versus limited-step reconstitution reveals key features of an RNA hairpin-stabilized paused transcription complex. J Biol Chem. 2007;282:19020-8 pubmed..Reconstitution of the his paused transcription complex provides a valuable tool for future studies of protein-nucleic interactions involved in transcriptional pausing. ..
- Colangeli R, Helb D, Vilcheze C, Hazbón M, Lee C, Safi H, et al. Transcriptional regulation of multi-drug tolerance and antibiotic-induced responses by the histone-like protein Lsr2 in M. tuberculosis. PLoS Pathog. 2007;3:e87 pubmed..An improved understanding of the role of lsr2 may provide important insights into the mechanisms of action of antibiotics and the way that mycobacteria adapt to stresses such as antibiotic treatment. ..
- Tang X, Shyr J, Tao L, Sedkova N, Cheng Q. Improvement of a CrtO-type of beta-carotene ketolase for canthaxanthin production in Methylomonas sp. Metab Eng. 2007;9:348-54 pubmed..Some mutations were found in many of the improved genes, suggesting that these sites, and possibly the regions around these sites, were important for improving the crtO's activity for canthaxanthin production...
- Geszvain K, Visick K. Multiple factors contribute to keeping levels of the symbiosis regulator RscS low. FEMS Microbiol Lett. 2008;285:33-9 pubmed publisher..Restriction of RscS levels may be important to prevent spurious signalling by this sensor kinase in the absence of a squid host...
- Mulay V, Caimano M, Iyer R, Dunham Ems S, Liveris D, Petzke M, et al. Borrelia burgdorferi bba74 is expressed exclusively during tick feeding and is regulated by both arthropod- and mammalian host-specific signals. J Bacteriol. 2009;191:2783-94 pubmed publisher..burgdorferi transitions between its arthropod vector and mammalian host. ..
- Gupta R, Shah P, Swiatlo E. Differential gene expression in Streptococcus pneumoniae in response to various iron sources. Microb Pathog. 2009;47:101-9 pubmed publisher..These findings suggest that a subset of virulence genes in pneumococci is differentially regulated in response to the quantity and form of iron sources available in a host. ..
- Mouser P, N guessan A, Elifantz H, Holmes D, Williams K, Wilkins M, et al. Influence of heterogeneous ammonium availability on bacterial community structure and the expression of nitrogen fixation and ammonium transporter genes during in situ bioremediation of uranium-contaminated groundwater. Environ Sci Technol. 2009;43:4386-92 pubmed..This study also emphasizes the need for more detailed analysis of geochemical and physiological interactions at the field scale in order to adequately model subsurface microbial processes during bioremediation. ..
- Richards G, Goodrich Blair H. Examination of Xenorhabdus nematophila lipases in pathogenic and mutualistic host interactions reveals a role for xlpA in nematode progeny production. Appl Environ Microbiol. 2010;76:221-9 pubmed publisher..Future research is aimed at characterizing the biological roles of estA and xlpA in other insect hosts...
- Haddix P, Straley S. Structure and regulation of the Yersinia pestis yscBCDEF operon. J Bacteriol. 1992;174:4820-8 pubmed..YscB and YscC were expressed in Escherichia coli by using a high-level transcription system. Attempts to express YscD were only partially successful, but they revealed interesting regulation at the translational level...
- Liu Y, Chatterjee A, Chatterjee A. Nucleotide sequence and expression of a novel pectate lyase gene (pel-3) and a closely linked endopolygalacturonase gene (peh-1) of Erwinia carotovora subsp. carotovora 71. Appl Environ Microbiol. 1994;60:2545-52 pubmed..Pel-3 also is unusual in that it is predicted to contain an ATP- and GTP-binding site motif A (P-loop) not found in the other Pels. ..
- Falcone D, Tabita F. Complementation analysis and regulation of CO2 fixation gene expression in a ribulose 1,5-bisphosphate carboxylase-oxygenase deletion strain of Rhodospirillum rubrum. J Bacteriol. 1993;175:5066-77 pubmed..The placement and orientation of the cbbR transcriptional regulator gene in R. rubrum are unique...
- McCarter L, Wright M. Identification of genes encoding components of the swarmer cell flagellar motor and propeller and a sigma factor controlling differentiation of Vibrio parahaemolyticus. J Bacteriol. 1993;175:3361-71 pubmed..This work initiates identification and placement of genes in a scheme of control for swarmer cell differentiation; three levels have been identified in the transcriptional hierarchy. ..
- Bagyan I, Noback M, Bron S, Paidhungat M, Setlow P. Characterization of yhcN, a new forespore-specific gene of Bacillus subtilis. Gene. 1998;212:179-88 pubmed..A yhcN mutant sporulates normally and yhcN spores have identical resistance properties to wild-type spores. However, the outgrowth of yhcN spores is slower than that of wild-type spores. ..
- Zhang Y, Pohlmann E, Ludden P, Roberts G. Mutagenesis and functional characterization of the glnB, glnA, and nifA genes from the photosynthetic bacterium Rhodospirillum rubrum. J Bacteriol. 2000;182:983-92 pubmed
- Gralnick J, Downs D. The YggX protein of Salmonella enterica is involved in Fe(II) trafficking and minimizes the DNA damage caused by hydroxyl radicals: residue CYS-7 is essential for YggX function. J Biol Chem. 2003;278:20708-15 pubmed publisher..We propose a model, based on data presented here and reported earlier, that suggests YggX is a player in Fe(II) trafficking in bacteria...
- Tseng C, Zhang S, Stewart G. Accessory gene regulator control of staphyloccoccal enterotoxin d gene expression. J Bacteriol. 2004;186:1793-801 pubmed..Therefore, the postexponential increase in sed transcription results from the Agr-mediated reduction in Rot activity rather than as a direct effect of the Agr system...
- You L, Cox R, Weiss R, Arnold F. Programmed population control by cell-cell communication and regulated killing. Nature. 2004;428:868-71 pubmed..This circuit incorporates a mechanism for programmed death in response to changes in the environment, and allows us to probe the design principles of its more complex natural counterparts. ..
- Cao S, Progulske Fox A, Hillman J, Handfield M. In vivo induced antigenic determinants of Actinobacillus actinomycetemcomitans. FEMS Microbiol Lett. 2004;237:97-103 pubmed..IVIAT is applicable to most pathogens and will undoubtedly lead to the discovery of novel therapies, antibiotics and diagnostic tools. ..
- Harris D, Tanaka M, Saveliev S, Jolivet E, Earl A, Cox M, et al. Preserving genome integrity: the DdrA protein of Deinococcus radiodurans R1. PLoS Biol. 2004;2:e304 pubmed..We propose that DR0423 is part of a DNA end-protection system that helps to preserve genome integrity following exposure to ionizing radiation. We designate the DR0423 protein as DNA damage response A protein. ..
- Lin Q, Rikihisa Y, Massung R, Woldehiwet Z, Falco R. Polymorphism and transcription at the p44-1/p44-18 genomic locus in Anaplasma phagocytophilum strains from diverse geographic regions. Infect Immun. 2004;72:5574-81 pubmed..These p44 loci provide insight into the molecular evolution and functional divergence of p44 paralogs and may serve as markers for typing strains from different geographic regions. ..
- Layton J, Foster P. Error-prone DNA polymerase IV is regulated by the heat shock chaperone GroE in Escherichia coli. J Bacteriol. 2005;187:449-57 pubmed..We were unable to show that GroE interacts directly with Pol IV, suggesting that GroE may act indirectly. Together with previous results, these findings indicate that Pol IV is a component of several cellular stress responses. ..
- Luo H, Wan K, Wang H. High-frequency conjugation system facilitates biofilm formation and pAMbeta1 transmission by Lactococcus lactis. Appl Environ Microbiol. 2005;71:2970-8 pubmed..lactis, at frequencies more than 10,000 times higher than those for the non-clumping parental donor strain. The implications of this finding for antibiotic resistance gene dissemination are discussed. ..
- Yang J, Sangwan I, Lindemann A, Hauser F, Hennecke H, Fischer H, et al. Bradyrhizobium japonicum senses iron through the status of haem to regulate iron homeostasis and metabolism. Mol Microbiol. 2006;60:427-37 pubmed..In addition, the haem mutant had an abnormally high cellular iron content. The findings indicate that B. japonicum senses iron via the status of haem biosynthesis in an Irr-dependent manner to regulate iron homeostasis and metabolism. ..
- Kappell A, Bhaya D, van Waasbergen L. Negative control of the high light-inducible hliA gene and implications for the activities of the NblS sensor kinase in the cyanobacterium Synechococcus elongatus strain PCC 7942. Arch Microbiol. 2006;186:403-13 pubmed..These results point to the evolutionary conservation of the HLR1 element and its importance in NblS-mediated signaling and yield new insight into NblS-mediated control of gene expression. ..
- Sharma A, Payne S. Induction of expression of hfq by DksA is essential for Shigella flexneri virulence. Mol Microbiol. 2006;62:469-79 pubmed
- Palmer K, Brown S, Whiteley M. Membrane-bound nitrate reductase is required for anaerobic growth in cystic fibrosis sputum. J Bacteriol. 2007;189:4449-55 pubmed..These findings suggest that the membrane-bound nitrate reductase is critical for P. aeruginosa anaerobic growth with nitrate in the CF lung. ..
- Blommel P, Becker K, Duvnjak P, Fox B. Enhanced bacterial protein expression during auto-induction obtained by alteration of lac repressor dosage and medium composition. Biotechnol Prog. 2007;23:585-98 pubmed..Upon the basis of the analysis of over 500 independent expression results, combinations of optimized expression media and expression plasmids that gave protein yields of greater than 1000 mug/mL of expression culture were identified. ..
- Ossa F, Diodati M, Caberoy N, Giglio K, Edmonds M, Singer M, et al. The Myxococcus xanthus Nla4 protein is important for expression of stringent response-associated genes, ppGpp accumulation, and fruiting body development. J Bacteriol. 2007;189:8474-83 pubmed..xanthus ppGpp synthetase gene relA, are altered in nla4 mutant cells. These findings indicate that Nla4 is part of regulatory pathway that is important for mounting a stringent response and for initiating fruiting body development. ..
- Malasarn D, Keeffe J, Newman D. Characterization of the arsenate respiratory reductase from Shewanella sp. strain ANA-3. J Bacteriol. 2008;190:135-42 pubmed..The development of a heterologous overexpression system for ARR will facilitate future structural and/or functional studies of this protein family. ..
- Donegan N, Cheung A. Regulation of the mazEF toxin-antitoxin module in Staphylococcus aureus and its impact on sigB expression. J Bacteriol. 2009;191:2795-805 pubmed publisher..The antibiotic response also appears to occur in two other TA systems in S. aureus, indicating a shared mechanism of regulation...
- Nguyen H, Wolff K, Cartabuke R, Ogwang S, Nguyen L. A lipoprotein modulates activity of the MtrAB two-component system to provide intrinsic multidrug resistance, cytokinetic control and cell wall homeostasis in Mycobacterium. Mol Microbiol. 2010;76:348-64 pubmed publisher..These results support a model in which LpqB, MtrB and MtrA form a three-component system that co-ordinates cytokinetic and cell wall homeostatic processes...
- Lombardo M, Bagga D, Miller C. Mutations in rpoA affect expression of anaerobically regulated genes in Salmonella typhimurium. J Bacteriol. 1991;173:7511-8 pubmed..They also suggest that the C-terminal region of alpha is important for these interactions. ..
- Jude B, Martinez R, Skorupski K, Taylor R. Levels of the secreted Vibrio cholerae attachment factor GbpA are modulated by quorum-sensing-induced proteolysis. J Bacteriol. 2009;191:6911-7 pubmed publisher..This could provide a mechanism for GbpA-mediated attachment to, and detachment from, surfaces in response to environmental cues. ..
- Palyada K, Sun Y, Flint A, Butcher J, Naikare H, Stintzi A. Characterization of the oxidative stress stimulon and PerR regulon of Campylobacter jejuni. BMC Genomics. 2009;10:481 pubmed publisher..This study reveals an interplay between PerR, Fur, iron metabolism and oxidative stress defense, and highlights the role of these elements in C. jejuni colonization of the chick cecum and/or subsequent survival. ..
- Price S, Leung K, Barve S, Straley S. Molecular analysis of lcrGVH, the V antigen operon of Yersinia pestis. J Bacteriol. 1989;171:5646-53 pubmed..However, two-dimensional gel analysis showed that net LcrH expression was regulated by Ca2+. We propose that lcrH lies within two differentially regulated operons, its own and lcrGVH. ..
- Cabrera Hernandez A, Sanchez Salas J, Paidhungat M, Setlow P. Regulation of four genes encoding small, acid-soluble spore proteins in Bacillus subtilis. Gene. 1999;232:1-10 pubmed..Mutations disrupting the sspH, sspL, sspN-tlp, or tlp loci cause a loss of the appropriate SASP from spores, but have no discernible effect on sporulation, spore properties, or spore germination. ..
- Scott J, Rasche M. Purification, overproduction, and partial characterization of beta-RFAP synthase, a key enzyme in the methanopterin biosynthesis pathway. J Bacteriol. 2002;184:4442-8 pubmed..extorquens is the first report of a putative methanopterin biosynthetic gene found in the Bacteria and provides evidence that the pathways of methanopterin biosynthesis in Bacteria and Archaea are similar...
- Browning D, Beatty C, Sanstad E, Gunn K, Busby S, Wolfe A. Modulation of CRP-dependent transcription at the Escherichia coli acsP2 promoter by nucleoprotein complexes: anti-activation by the nucleoid proteins FIS and IHF. Mol Microbiol. 2004;51:241-54 pubmed..We propose that FIS and IHF each function directly as anti-activators of CRP, each working independently at different times during growth to set the levels of CRP-dependent acs transcription. ..
- Malakooti J, Wang S, Ely B. A consensus promoter sequence for Caulobacter crescentus genes involved in biosynthetic and housekeeping functions. J Bacteriol. 1995;177:4372-6 pubmed
- Cabrera Hernandez A, Setlow P. Analysis of the regulation and function of five genes encoding small, acid-soluble spore proteins of Bacillus subtilis. Gene. 2000;248:169-81 pubmed..Loss of sspI also had no effect on sporulation, spore properties or spore germination, but DeltasspI spores had a significant defect in spore outgrowth. ..
- Sfakianakis A, Barr C, Kreutzer D. Mechanisms of Actinobacillus actinomycetemcomitans-induced expression of interleukin-8 in gingival epithelial cells. J Periodontol. 2001;72:1413-9 pubmed..Understanding mechanisms of proinflammatory cytokine induction is important in periodontal pathology as it may lead to novel therapeutic approaches for periodontitis, thus controlling host inflammatory responses. ..
- Wang B, Kuramitsu H. Control of enzyme IIscr and sucrose-6-phosphate hydrolase activities in Streptococcus mutans by transcriptional repressor ScrR binding to the cis-active determinants of the scr regulon. J Bacteriol. 2003;185:5791-9 pubmed..Our results indicated that S. mutans coordinates the activities of enzyme II(scr) and sucrose-6-phosphate hydrolase by transcriptional repressor ScrR binding to the promoter regions of the scr regulon. ..
- Lan L, Deng X, Zhou J, Tang X. Genome-wide gene expression analysis of Pseudomonas syringae pv. tomato DC3000 reveals overlapping and distinct pathways regulated by hrpL and hrpRS. Mol Plant Microbe Interact. 2006;19:976-87 pubmed publisher..The novel genes and pathways identified by the microarray provide new insight into the bacterial functions coordinating with the TTSS...
- Chatterjee A, Cui Y, Chatterjee A. RsmA and the quorum-sensing signal, N-[3-oxohexanoyl]-L-homoserine lactone, control the levels of rsmB RNA in Erwinia carotovora subsp. carotovora by affecting its stability. J Bacteriol. 2002;184:4089-95 pubmed..The findings reported here firmly establish that the quorum-sensing signal is channeled in E. carotovora subsp. carotovora via the rsmA-rsmB posttranscriptional regulatory system...
- Huang T, Wong A. A cyclic AMP receptor protein-regulated cell-cell communication system mediates expression of a FecA homologue in Stenotrophomonas maltophilia. Appl Environ Microbiol. 2007;73:5034-40 pubmed..We propose that CRP may serve as a checkpoint for iron uptake, protease activity, and hemolysis in response to environmental changes such as changes in concentrations of glucose, cAMP, iron, or DSF. ..
- Abranches J, Nascimento M, Zeng L, Browngardt C, Wen Z, Rivera M, et al. CcpA regulates central metabolism and virulence gene expression in Streptococcus mutans. J Bacteriol. 2008;190:2340-9 pubmed publisher..5, and could acidify the environment more rapidly and to a greater extent than the parental strain. Thus, CcpA directly modulates the pathogenic potential of S. mutans through global control of gene expression. ..
- Ferrell E, Carty N, Colmer Hamood J, Hamood A, West S. Regulation of Pseudomonas aeruginosa ptxR by Vfr. Microbiology. 2008;154:431-9 pubmed publisher..Our results suggest that Vfr modulates toxA and lasB expression in PAO1 through PtxR. A model defining the relationships between these different genes is presented. ..
- Chen S, Bleam W, Hickey W. Molecular analysis of two bacterioferritin genes, bfralpha and bfrbeta, in the model rhizobacterium Pseudomonas putida KT2440. Appl Environ Microbiol. 2010;76:5335-43 pubmed publisher..Furthermore, regardless of the mechanism, a primary benefit of the bacterioferritins to P. putida KT2440 appears to be the enhancement of its survival in the environment by strengthening its tolerance to iron starvation. ..
- Thompson D, Beliaev A, Giometti C, Tollaksen S, Khare T, Lies D, et al. Transcriptional and proteomic analysis of a ferric uptake regulator (fur) mutant of Shewanella oneidensis: possible involvement of fur in energy metabolism, transcriptional regulation, and oxidative stress. Appl Environ Microbiol. 2002;68:881-92 pubmed..These results suggest a possible regulatory role of S. oneidensis MR-1 Fur in energy metabolism that extends the traditional model of Fur as a negative regulator of iron acquisition systems. ..
- Purkayastha A, McCue L, McDonough K. Identification of a Mycobacterium tuberculosis putative classical nitroreductase gene whose expression is coregulated with that of the acr aene within macrophages, in standing versus shaking cultures, and under low oxygen conditions. Infect Immun. 2002;70:1518-29 pubmed..We propose that these differences might be exploited for dissection of the regulatory factors that affect mycobacterial gene expression within the host. ..
- Palacios S, Escalante Semerena J. 2-Methylcitrate-dependent activation of the propionate catabolic operon (prpBCDE) of Salmonella enterica by the PrpR protein. Microbiology. 2004;150:3877-87 pubmed publisher..Analysis of the binding-site sequence revealed two sites with dyad symmetry. Results from DNase I footprinting assays suggested that the PrpR protein may have higher affinity for the site proximal to the P(prpBCDE) promoter...
- Albano M, Smits W, Ho L, Kraigher B, Mandic Mulec I, Kuipers O, et al. The Rok protein of Bacillus subtilis represses genes for cell surface and extracellular functions. J Bacteriol. 2005;187:2010-9 pubmed..We present evidence for the recent introduction of rok into the B. subtilis-Bacillus licheniformis-Bacilllus amyloliquefaciens group by horizontal transmission. ..
- Anthony J, Warczak K, Donohue T. A transcriptional response to singlet oxygen, a toxic byproduct of photosynthesis. Proc Natl Acad Sci U S A. 2005;102:6502-7 pubmed..Gene products encoded by four newly identified sigma(E)-dependent operons are predicted to be involved in stress response, protecting cells from 1O2 damage, or the conservation of energy. ..
- Kumari S, Beatty C, Browning D, Busby S, Simel E, Hovel Miner G, et al. Regulation of acetyl coenzyme A synthetase in Escherichia coli. J Bacteriol. 2000;182:4173-9 pubmed
- Griswold A, Chen Y, Snyder J, Burne R. Characterization of the arginine deiminase operon of Streptococcus rattus FA-1. Appl Environ Microbiol. 2004;70:1321-7 pubmed..Reporter gene fusions and AD assays demonstrated that the operon is regulated by substrate induction and catabolite repression, the latter apparently through a CcpA-dependent pathway...
- Staggs T, Perry R. Fur regulation in Yersinia species. Mol Microbiol. 1992;6:2507-16 pubmed..pestis fur gene. These data indicate that Y. pestis and Y. enterocolitica possess homologous Fur systems which regulate expression of proteins in response to iron availability...
- Nichols T, Whitehouse C, Austin F. Transcriptional analysis of a superoxide dismutase gene of Borrelia burgdorferi. FEMS Microbiol Lett. 2000;183:37-42 pubmed..burgdorferi. A transcriptional start site of this operon, containing -10 and -35 regions of a sigma(70)-type promoter, was mapped to 100 bp upstream of the ATG start codon of secA. ..
- Jiang G, Krishnan A, Kim Y, Wacek T, Krishnan H. A functional myo-inositol dehydrogenase gene is required for efficient nitrogen fixation and competitiveness of Sinorhizobium fredii USDA191 to nodulate soybean (Glycine max [L.] Merr.). J Bacteriol. 2001;183:2595-604 pubmed publisher..Thus, we conclude that a functional idhA gene is required for efficient nitrogen fixation and for competitive nodulation of soybeans by S. fredii USDA191...
- Palacios S, Starai V, Escalante Semerena J. Propionyl coenzyme A is a common intermediate in the 1,2-propanediol and propionate catabolic pathways needed for expression of the prpBCDE operon during growth of Salmonella enterica on 1,2-propanediol. J Bacteriol. 2003;185:2802-10 pubmed
- Redford P, Welch R. Role of sigma E-regulated genes in Escherichia coli uropathogenesis. Infect Immun. 2006;74:4030-8 pubmed..A mutant of degQ, a close homolog of degP, was not attenuated in mice. This is the first report that the DegP degradase is an E. coli virulence factor in an animal infection model. ..
- Winkelman J, Blair K, Kearns D. RemA (YlzA) and RemB (YaaB) regulate extracellular matrix operon expression and biofilm formation in Bacillus subtilis. J Bacteriol. 2009;191:3981-91 pubmed publisher..Both proteins are required for the activation of the matrix biosynthesis operons and appear to act in parallel to SinR and two other known biofilm regulators, AbrB and DegU. ..
- Downs D, Petersen L. apbA, a new genetic locus involved in thiamine biosynthesis in Salmonella typhimurium. J Bacteriol. 1994;176:4858-64 pubmed..typhimurium, and furthermore, the pur genetic background of the strain influences whether this pathway can function under aerobic and/or anaerobic growth conditions. ..
- Ahmer B, van Reeuwijk J, Timmers C, Valentine P, Heffron F. Salmonella typhimurium encodes an SdiA homolog, a putative quorum sensor of the LuxR family, that regulates genes on the virulence plasmid. J Bacteriol. 1998;180:1185-93 pubmed..The three ORFs have now been named srgA, srgB, and srgC (for sdiA-regulated gene), respectively. The DNA sequence adjacent to the remaining three fusions shared no similarity with previously described genes. ..
- Drees J, Lusetti S, Cox M. Inhibition of RecA protein by the Escherichia coli RecX protein: modulation by the RecA C terminus and filament functional state. J Biol Chem. 2004;279:52991-7 pubmed..We further identified a C-terminal point mutation in RecA protein (E343K) that significantly alters the interaction between RecA and RecX proteins. ..
- Viollier P, Shapiro L. Spatial complexity of mechanisms controlling a bacterial cell cycle. Curr Opin Microbiol. 2004;7:572-8 pubmed
- Rutherford S, Lemke J, Vrentas C, Gaal T, Ross W, Gourse R. Effects of DksA, GreA, and GreB on transcription initiation: insights into the mechanisms of factors that bind in the secondary channel of RNA polymerase. J Mol Biol. 2007;366:1243-57 pubmed..Our results provide important clues to the mechanisms of both negative and positive control of transcription initiation by DksA. ..
- Darnell C, Hussa E, Visick K. The putative hybrid sensor kinase SypF coordinates biofilm formation in Vibrio fischeri by acting upstream of two response regulators, SypG and VpsR. J Bacteriol. 2008;190:4941-50 pubmed publisher..These data support a model in which a network of regulators and at least two polysaccharide loci contribute to biofilm formation in V. fischeri...
- Sohaskey C, Modesti L. Differences in nitrate reduction between Mycobacterium tuberculosis and Mycobacterium bovis are due to differential expression of both narGHJI and narK2. FEMS Microbiol Lett. 2009;290:129-34 pubmed publisher..bovis or BCG. Insertion of the M. tuberculosis narGHJI operon into M. bovis resulted in increased activity only during AG. Regulation of both the nitrate reductase enzyme and transporter are regulated differently in the two species...
- Curtis P, Brun Y. Getting in the loop: regulation of development in Caulobacter crescentus. Microbiol Mol Biol Rev. 2010;74:13-41 pubmed publisher..While much has been discovered about Caulobacter crescentus development, areas of potential future research are also highlighted. ..
- Jorth P, Whiteley M. Characterization of a novel riboswitch-regulated lysine transporter in Aggregatibacter actinomycetemcomitans. J Bacteriol. 2010;192:6240-50 pubmed publisher..Finally, we demonstrated that lysT and the lysT lysine riboswitch are conserved in over 40 bacterial species, including the phylogenetically related pathogen Haemophilus influenzae. ..
- Tsolis R, Bäumler A, Stojiljkovic I, Heffron F. Fur regulon of Salmonella typhimurium: identification of new iron-regulated genes. J Bacteriol. 1995;177:4628-37 pubmed..In addition, we identified three genes with homologs in other bacteria which have not previously been shown to be Fur regulated. ..
- Oliver D, Norman J, Sarker S. Regulation of Escherichia coli secA by cellular protein secretion proficiency requires an intact gene X signal sequence and an active translocon. J Bacteriol. 1998;180:5240-2 pubmed..Furthermore, gene X signal sequence mutations disrupted secA regulation only in the cis configuration. We propose that nascent pre-gene X protein interacts with the translocon during its secretion to constitute the secretion sensor. ..
- Murray H, Schneider D, Gourse R. Control of rRNA expression by small molecules is dynamic and nonredundant. Mol Cell. 2003;12:125-34 pubmed..The results suggest a molecular logic for the use of two homeostatic regulatory mechanisms to monitor different aspects of ribosome activity and provide general insights into the nature of overlapping regulatory circuits. ..
- Li L, Alvey R, Bezy R, Kehoe D. Inverse transcriptional activities during complementary chromatic adaptation are controlled by the response regulator RcaC binding to red and green light-responsive promoters. Mol Microbiol. 2008;68:286-97 pubmed publisher..These results provide important insights into the long-standing enigma of CCA regulation and complete the first description of an entire two-component system controlled by a phytochrome-class photoreceptor. ..
- Chang Y, Wesenberg G, Bingman C, Fox B. In vivo inactivation of the mycobacterial integral membrane stearoyl coenzyme A desaturase DesA3 by a C-terminus-specific degradation process. J Bacteriol. 2008;190:6686-96 pubmed publisher..Among these, an annotation is known for less than half, underscoring a general lack of understanding of proteins that have only temporal existence in a cell. ..
- Beltramini A, Mukhopadhyay C, Pancholi V. Modulation of cell wall structure and antimicrobial susceptibility by a Staphylococcus aureus eukaryote-like serine/threonine kinase and phosphatase. Infect Immun. 2009;77:1406-16 pubmed publisher..Together, these results indicate that S. aureus STK- and STP-mediated reversible phosphorylation reactions play a critical role in proper cell wall architecture, and thus the modulation of antimicrobial resistance, in S. aureus. ..
- Stefanova M, Tomberg J, Olesky M, Höltje J, Gutheil W, Nicholas R. Neisseria gonorrhoeae penicillin-binding protein 3 exhibits exceptionally high carboxypeptidase and beta-lactam binding activities. Biochemistry. 2003;42:14614-25 pubmed..gonorrhoeae, although deletion of both PBP 3 and PBP 4, the other low-molecular-mass PBP in N. gonorrhoeae, resulted in a decreased growth rate and marked morphological abnormalities. ..
- Artsimovitch I, Patlan V, Sekine S, Vassylyeva M, Hosaka T, Ochi K, et al. Structural basis for transcription regulation by alarmone ppGpp. Cell. 2004;117:299-310 pubmed..We present experimental evidence highlighting the importance of base-specific contacts between ppGpp and specific cytosine residues during both transcription initiation and elongation...
- Friedrich A, ARVIDSON C, Shafer W, Lee E, So M. Two ABC transporter operons and the antimicrobial resistance gene mtrF are pilT responsive in Neisseria gonorrhoeae. J Bacteriol. 2007;189:5399-402 pubmed..This effect occurs indirectly through the transcriptional regulator FarR, which until now has been shown to regulate only farAB. L-Glutamine can reverse pilT downregulation of the ABC transporter operons and mtrF...
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