Genomes and Genes
Experts and Doctors on axons in Germany
Publications232 found, 100 shown here
- Robles E, Filosa A, Baier H. Precise lamination of retinal axons generates multiple parallel input pathways in the tectum. J Neurosci. 2013;33:5027-39 pubmed publisher..These findings suggest that lamina-specific sorting of retinal inputs provides an anatomical blueprint for the integration of visual features in the tectum. ..
- Ahuja G, Ivandić I, Saltürk M, Oka Y, Nadler W, Korsching S. Zebrafish crypt neurons project to a single, identified mediodorsal glomerulus. Sci Rep. 2013;3:2063 pubmed publisher..Our data provide strong evidence that crypt neurons converge onto a single glomerulus, and thus form a labeled line consisting of a single sensory cell type, a single olfactory receptor and a single target glomerulus. ..
- Hein I, Suzuki T, Grunwald Kadow I. Gogo receptor contributes to retinotopic map formation and prevents R1-6 photoreceptor axon bundling. PLoS ONE. 2013;8:e66868 pubmed publisher..In a later developmental step, the regular position of R1-R6 axons along the lamina plexus is crucial for target cartridge selection. During cartridge elongation, Gogo allows R1-R6 axons to extend centrally in the lamina cartridge. ..
- Alvarez Bolado G, Zhou X, Voss A, Thomas T, Gruss P. Winged helix transcription factor Foxb1 is essential for access of mammillothalamic axons to the thalamus. Development. 2000;127:1029-38 pubmed..Our results indicate that Foxb1 is essential for diencephalic histogenesis and that it exerts its effects by controlling access to the target by one particular axonal branch. ..
- Oertner T, Brotz T, Borst A. Mechanisms of dendritic calcium signaling in fly neurons. J Neurophysiol. 2001;85:439-47 pubmed..In summary, the characteristic spatiotemporal calcium signals in the dendrites of lobula plate tangential cells can be reproduced in vitro, and result from a combination of voltage- and ligand-gated calcium influx...
- Breer H. Sense of smell: recognition and transduction of olfactory signals. Biochem Soc Trans. 2003;31:113-6 pubmed..The emerging chemotopic maps are considered to be crucial for processing and encoding sensory information of olfactory stimuli. ..
- Prüss H, Wenzel M, Eulitz D, Thomzig A, Karschin A, Veh R. Kir2 potassium channels in rat striatum are strategically localized to control basal ganglia function. Brain Res Mol Brain Res. 2003;110:203-19 pubmed..The heterogeneous localization of the Kir2.3 and the Kir2.4 subunits with respect to these strategic structures pinpoints to these channel proteins as promising targets for future pharmacological efforts. ..
- Benninger F, Beck H, Wernig M, Tucker K, Brüstle O, Scheffler B. Functional integration of embryonic stem cell-derived neurons in hippocampal slice cultures. J Neurosci. 2003;23:7075-83 pubmed..Thus, ES cell-derived neural precursors generate functionally active neurons capable of integrating into the brain circuitry. ..
- Eberhorn A, Horn A, Eberhorn N, Fischer P, Boergen K, Büttner Ennever J. Palisade endings in extraocular eye muscles revealed by SNAP-25 immunoreactivity. J Anat. 2005;206:307-15 pubmed..They seem to be a general feature of all vertebrate eye muscles, unlike the other two extraocular proprioceptors, muscle spindles and Golgi tendon organs, the presence of which varies widely between species. ..
- Janssen Bienhold U, Trümpler J, Hilgen G, Schultz K, Müller L, Sonntag S, et al. Connexin57 is expressed in dendro-dendritic and axo-axonal gap junctions of mouse horizontal cells and its distribution is modulated by light. J Comp Neurol. 2009;513:363-74 pubmed publisher..This study shows for the first time the detailed location of connexin57 expression within mouse horizontal cells, and provides the first ultrastructural data on mouse horizontal cell gap junctions. ..
- Rak K, Lechner B, Schneider C, Drexl H, Sendtner M, Jablonka S. Valproic acid blocks excitability in SMA type I mouse motor neurons. Neurobiol Dis. 2009;36:477-87 pubmed publisher..Our data indicate effects of VPA which might aggravate disease-specific symptoms in SMA patients. ..
- Koch J, Knöferle J, Tönges L, Michel U, Bahr M, Lingor P. Imaging of rat optic nerve axons in vivo. Nat Protoc. 2011;6:1887-96 pubmed publisher..Furthermore, the effects of pharmacological manipulations on axonal stability and axonal calcium kinetics in axons of the central nervous system can be studied in vivo. ..
- Niederleitner B, Luksch H. Neuronal morphology in subdivisions of the inferior colliculus of chicken (Gallus gallus). J Chem Neuroanat. 2012;44:24-33 pubmed publisher..The auditory system in chicken is not as hypertrophied as in specialists such as the barn owl, but appears to have comparable connectivity and cellular morphology. ..
- Carroll P, Lewin G, Koltzenburg M, Toyka K, Thoenen H. A role for BDNF in mechanosensation. Nat Neurosci. 1998;1:42-6 pubmed..Postnatal treatment of BDNF +/- mice with recombinant BDNF completely rescued the mechanosensitivity deficit. Therefore BDNF is important for regulating SAM mechanosensitivity, independent of any survival-promoting function. ..
- Steffensky M, Steinbach K, Schwarz U, Schlosshauer B. Differential impact of semaphorin 3E and 3A on CNS axons. Int J Dev Neurosci. 2006;24:65-72 pubmed..Our results suggest a molecular mechanism whereby ingrowth of retinal axons into the tectum can be regulated by Sema3E/BDNF modulation without disturbing tectal axon growth out of the tectum mediated by Sema3A. ..
- Wirths O, Weis J, Kayed R, Saido T, Bayer T. Age-dependent axonal degeneration in an Alzheimer mouse model. Neurobiol Aging. 2007;28:1689-99 pubmed..We conclude that the intraneuronal accumulation of Abeta-amyloid peptides is followed by axonal degeneration, and thus might be a causative factor for the axonal changes seen in AD. ..
- Dudanova I, Gatto G, Klein R. GDNF acts as a chemoattractant to support ephrinA-induced repulsion of limb motor axons. Curr Biol. 2010;20:2150-6 pubmed publisher..GDNF also acts in a permissive manner by reducing ephrinA-induced collapse and keeping the axons in a growth-competent state. This is the first example of two opposing cues promoting the same trajectory choice at an intermediate target. ..
- Huettl R, Soellner H, Bianchi E, Novitch B, Huber A. Npn-1 contributes to axon-axon interactions that differentially control sensory and motor innervation of the limb. PLoS Biol. 2011;9:e1001020 pubmed publisher..Thus, motor and sensory axons are mutually dependent on each other for the generation of their trajectories and interact in part through Npn-1-mediated fasciculation before and within the plexus region of the limbs...
- Martin R, Door R, Breitig D. High-resolution imaging of protein phosphorylation in squid axons and synapse by electron energy loss spectroscopy. J Histochem Cytochem. 1993;41:1133-9 pubmed..Our method may be advantageous for analysis with high elemental and spatial resolution of the phosphorylation state of cytoskeletal protein molecules in situ. ..
- Schumacher S, Jung M, Nörenberg U, Dorner A, Chiquet Ehrismann R, Stuermer C, et al. CALEB binds via its acidic stretch to the fibrinogen-like domain of tenascin-C or tenascin-R and its expression is dynamically regulated after optic nerve lesion. J Biol Chem. 2001;276:7337-45 pubmed..These investigations demonstrate that CALEB mRNA is dynamically regulated after optic nerve lesion and that this mRNA is expressed in most developing and in one-third of the few regenerating (GAP-43 expressing) retinal ganglion cells. ..
- Koester H, Sakmann B. Calcium dynamics associated with action potentials in single nerve terminals of pyramidal cells in layer 2/3 of the young rat neocortex. J Physiol. 2000;529 Pt 3:625-46 pubmed..This could indicate that local interactions between boutons and different target cells modify the spatiotemporal Ca2+ dynamics in boutons and cause target cell-specific differences in their transmitter release properties. ..
- Kalla R, Liu Z, Xu S, Koppius A, Imai Y, Kloss C, et al. Microglia and the early phase of immune surveillance in the axotomized facial motor nucleus: impaired microglial activation and lymphocyte recruitment but no effect on neuronal survival or axonal regeneration in macrophage-colony stimulating factor-d. J Comp Neurol. 2001;436:182-201 pubmed..However, it is important in the initiation of inflammatory changes in the brain and in the interaction with the immune system. ..
- Kretschmer T, England J, Happel L, Liu Z, Thouron C, Nguyen D, et al. Ankyrin G and voltage gated sodium channels colocalize in human neuroma--key proteins of membrane remodeling after axonal injury. Neurosci Lett. 2002;323:151-5 pubmed..A dysregulation in this membrane remodeling mechanism might be an initial step in a cascade that leads to a painful rather than a non-painful neuroma. ..
- Peters E, Botchkarev V, Müller Röver S, Moll I, Rice F, Paus R. Developmental timing of hair follicle and dorsal skin innervation in mice. J Comp Neurol. 2002;448:28-52 pubmed..This sequence of developing innervation consistently correlates with hair follicle development, indicating a close interdependence of neuronal and epithelial morphogenesis. ..
- Rünker A, Bartsch U, Nave K, Schachner M. The C264Y missense mutation in the extracellular domain of L1 impairs protein trafficking in vitro and in vivo. J Neurosci. 2003;23:277-86 pubmed..These observations corroborate the view that impaired cell surface expression of mutated variants of L1 is a potential explanation for the high number of severe pathogenic mutations identified within the human L1 gene. ..
- Senderek J, Bergmann C, Ramaekers V, Nelis E, Bernert G, Makowski A, et al. Mutations in the ganglioside-induced differentiation-associated protein-1 (GDAP1) gene in intermediate type autosomal recessive Charcot-Marie-Tooth neuropathy. Brain. 2003;126:642-9 pubmed..These findings fitted the definition of intermediate type CMT and further support the view that GDAP1 is vital for both, axonal integrity and Schwann cell properties. ..
- Prang P, Del Turco D, Deller T. Associational sprouting in the mouse fascia dentata after entorhinal lesion in vitro. Brain Res. 2003;978:205-12 pubmed..Using organotypic entorhino-hippocampal slices of genetically engineered mice, this sprouting model can be used to identify molecules involved in the regulation of sprouting following brain injury. ..
- Mi W, Beirowski B, Gillingwater T, Adalbert R, Wagner D, Grumme D, et al. The slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice. Brain. 2005;128:405-16 pubmed..We conclude that axon degeneration mechanisms are more closely related than previously thought and that a link exists in gad between spheroid pathology and Wallerian degeneration that could hold for other disorders...
- Marx M, Rivera Milla E, Stummeyer K, Gerardy Schahn R, Bastmeyer M. Divergent evolution of the vertebrate polysialyltransferase Stx and Pst genes revealed by fish-to-mammal comparison. Dev Biol. 2007;306:560-71 pubmed..Our findings reveal an important divergence of Stx and Pst enzymes in vertebrates, which is also characterized by a differential gene loss and rapid evolution of Pst genes within the bony-fish class. ..
- Mashaly A, Winkler M, Frambach I, Gras H, Schürmann F. Sprouting interneurons in mushroom bodies of adult cricket brains. J Comp Neurol. 2008;508:153-74 pubmed publisher..Our results are discussed in the context of Kenyon cell classification, growth dynamics, axonal fiber maturation, and function. ..
- Selvaraj B, Frank N, Bender F, Asan E, Sendtner M. Local axonal function of STAT3 rescues axon degeneration in the pmn model of motoneuron disease. J Cell Biol. 2012;199:437-51 pubmed publisher..This mechanism could also be relevant for other neurodegenerative diseases and provide a target for new therapies for axonal degeneration. ..
- Groh J, Kühl T, Ip C, Nelvagal H, Sri S, Duckett S, et al. Immune cells perturb axons and impair neuronal survival in a mouse model of infantile neuronal ceroid lipofuscinosis. Brain. 2013;136:1083-101 pubmed publisher..Finally, reconstitution experiments revealed a crucial role of CD8+ T-lymphocytes in pathogenesis. Our study provides novel pathomechanistic insights that may be crucial for developing treatment strategies. ..
- Becker C, Schweitzer J, Feldner J, Becker T, Schachner M. Tenascin-R as a repellent guidance molecule for developing optic axons in zebrafish. J Neurosci. 2003;23:6232-7 pubmed..Branches were almost exclusively caudal, where tenascin-R immunoreactivity normally borders the optic tract, suggesting a role for tenascin-R in guiding optic axons in the ventral diencephalon by a contact-repellent mechanism. ..
- Stang F, Fansa H, Wolf G, Keilhoff G. Collagen nerve conduits--assessment of biocompatibility and axonal regeneration. Biomed Mater Eng. 2005;15:3-12 pubmed..From these results, we conclude that a sufficient biocompatibility of bioartificial nerve conduits is a necessary prerequisite, however, it remains only one of several parameters important for peripheral nerve regeneration. ..
- Morrissey S, Le Page E, Edan G. Mitoxantrone in the treatment of multiple sclerosis. Int MS J. 2005;12:74-87 pubmed..This review examines the properties of mitoxantrone, its tolerability, and discusses its suitability for treating various forms of MS, referring to several important studies. ..
- Ahlborn P, Schachner M, Irintchev A. One hour electrical stimulation accelerates functional recovery after femoral nerve repair. Exp Neurol. 2007;208:137-44 pubmed
- Schneider T, Reiter C, Eule E, Bader B, Lichte B, Nie Z, et al. Restricted expression of the irreC-rst protein is required for normal axonal projections of columnar visual neurons. Neuron. 1995;15:259-71 pubmed..Epigenesis of the phenotypes can be explained partially on the bases of homophilic irreC-rst interactions. ..
- Lappe Siefke C, Goebbels S, Gravel M, Nicksch E, Lee J, Braun P, et al. Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination. Nat Genet. 2003;33:366-74 pubmed..Oligodendrocyte dysfunction, such as that in multiple sclerosis lesions, may suffice to cause secondary axonal loss. ..
- Heiduschka P, Thanos S. Cortisol promotes survival and regeneration of axotomised retinal ganglion cells and enhances effects of aurintricarboxylic acid. Graefes Arch Clin Exp Ophthalmol. 2006;244:1512-21 pubmed..The results show that both neuroprotection and regeneration can be enhanced by the combination of two simple compounds acting on different sites. ..
- Guseva D, Zerwas M, Xiao M, Jakovcevski I, Irintchev A, Schachner M. Adhesion molecule L1 overexpressed under the control of the neuronal Thy-1 promoter improves myelination after peripheral nerve injury in adult mice. Exp Neurol. 2011;229:339-52 pubmed publisher..Our results indicate that L1 is a regulator of myelination in the injured PNS and warrant studies aiming to improve function in demyelinating PNS and CNS disorders using exogenous L1. ..
- Brandt R, Leger J, Lee G. Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain. J Cell Biol. 1995;131:1327-40 pubmed..Our data suggest that tau's amino-terminal projection domain has an important role in neuritic development and establishes tau as a mediator of microtubule-plasma membrane interactions. ..
- Marg A, Sirim P, Spaltmann F, Plagge A, Kauselmann G, Buck F, et al. Neurotractin, a novel neurite outgrowth-promoting Ig-like protein that interacts with CEPU-1 and LAMP. J Cell Biol. 1999;145:865-76 pubmed..Our data suggest that neurotractin participates in the regulation of neurite outgrowth in the developing brain. ..
- Werner A, Willem M, Jones L, Kreutzberg G, Mayer U, Raivich G. Impaired axonal regeneration in alpha7 integrin-deficient mice. J Neurosci. 2000;20:1822-30 pubmed..The associated delay in the reinnervation of the whiskerpad, a peripheral target of the facial motor neurons, points to an important role for this integrin in the successful execution of axonal regeneration. ..
- Tucker K, Meyer M, Barde Y. Neurotrophins are required for nerve growth during development. Nat Neurosci. 2001;4:29-37 pubmed
- Becker T, Becker C. Regenerating descending axons preferentially reroute to the gray matter in the presence of a general macrophage/microglial reaction caudal to a spinal transection in adult zebrafish. J Comp Neurol. 2001;433:131-47 pubmed..We suggest that the spontaneous regeneration of axons of supraspinal origin after spinal cord transection in adult zebrafish may be due in part to the axons' ability to negotiate novel pathways in the spinal cord gray matter. ..
- Mack T, Reiner M, Beirowski B, Mi W, Emanuelli M, Wagner D, et al. Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene. Nat Neurosci. 2001;4:1199-206 pubmed..Nmnat enzyme activity, but not NAD+ content, was increased fourfold in WldS tissues. Thus, axon protection is likely to be mediated by altered ubiquitination or pyridine nucleotide metabolism. ..
- Schimmelpfeng K, Strunk M, Stork T, Klämbt C. Mummy encodes an UDP-N-acetylglucosamine-dipohosphorylase and is required during Drosophila dorsal closure and nervous system development. Mech Dev. 2006;123:487-99 pubmed..These phenotypes correlate well with specific glycosylation and GPI-anchorage defects in mummy mutants. ..
- Kukley M, Capetillo Zarate E, Dietrich D. Vesicular glutamate release from axons in white matter. Nat Neurosci. 2007;10:311-20 pubmed..This axonal transmitter release represents a widespread mechanism for high-fidelity, activity-dependent signaling at the axon-glia interface in white matter. ..
- Grosheva M, Guntinas Lichius O, Angelova S, Kuerten S, Alvanou A, Streppel M, et al. Local stabilization of microtubule assembly improves recovery of facial nerve function after repair. Exp Neurol. 2008;209:131-44 pubmed..We found that only stabilization of microtubules with 10 microg/ml taxol reduced intramuscular axonal sprouting and polyinnervation of the motor end-plates, which was accompanied by improved restoration of function. ..
- Siebert M, Banovic D, Goellner B, Aberle H. Drosophila motor axons recognize and follow a Sidestep-labeled substrate pathway to reach their target fields. Genes Dev. 2009;23:1052-62 pubmed publisher..Furthermore, Beat interacts with Side both genetically and biochemically. These results suggest that the tracing of Side-labeled cell surfaces by Beat-expressing growth cones is a major principle of motor axon guidance in Drosophila. ..
- Hellal F, Hurtado A, Ruschel J, FLYNN K, Laskowski C, Umlauf M, et al. Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury. Science. 2011;331:928-31 pubmed publisher..Thus, microtubule stabilization reduces fibrotic scarring and enhances the capacity of axons to grow...
- Stern M, Scheiblich H, Eickhoff R, Didwischus N, Bicker G. Regeneration of olfactory afferent axons in the locust brain. J Comp Neurol. 2012;520:679-93 pubmed publisher..In conclusion, axonal regeneration in the locust olfactory system appears to be possible, precise, and fast, opening the possibility of future functional and mechanistic studies. ..
- Schmidt A, Minnerup J. Promoting recovery from ischemic stroke. Expert Rev Neurother. 2016;16:173-86 pubmed publisher..We explain molecular and structural processes that promote neural plasticity, discuss potential limitations of neurorestorative treatments, and offer a speculative viewpoint on how neurorestorative treatments will evolve. ..
- Weber M, Birklein F, Neundorfer B, Schmelz M. Facilitated neurogenic inflammation in complex regional pain syndrome. Pain. 2001;91:251-7 pubmed..We conclude that neurogenic inflammation is facilitated in CRPS. Our results suggest an increased releasability of neuropeptides in CRPS...
- Loesel R, Homberg U. Anatomy and physiology of neurons with processes in the accessory medulla of the cockroach Leucophaea maderae. J Comp Neurol. 2001;439:193-207 pubmed..Finally, neurons responding to movement stimuli did not arborize in the AMe. The results show that the AMe receives photic input and support a role of this neuropil in circadian timekeeping functions. ..
- Gruhn M, Rathmayer W. An implantable electrode design for both chronic in vivo nerve recording and axon stimulation in freely behaving crayfish. J Neurosci Methods. 2002;118:33-40 pubmed..In vivo stimulation could be performed for at least 3 1/2 weeks. The implantable double hook is suitable for widespread use in invertebrate neurobiology. ..
- Fischer M, Reeh P, Sauer S. Proton-induced calcitonin gene-related peptide release from rat sciatic nerve axons, in vitro, involving TRPV1. Eur J Neurosci. 2003;18:803-10 pubmed..Axonal sensitivity to and sensitization by protons may be a pathophysiological mechanism involved in certain peripheral neuropathies. ..
- Onel S, Bolke L, Klämbt C. The Drosophila ARF6-GEF Schizo controls commissure formation by regulating Slit. Development. 2004;131:2587-94 pubmed..We thus propose that the balance of the two signaling cues Netrin and Slit can be regulated, controlling membrane dynamics. ..
- Kerr J, Greenberg D, Helmchen F. Imaging input and output of neocortical networks in vivo. Proc Natl Acad Sci U S A. 2005;102:14063-8 pubmed..The dissection of the various signal components in bulk-loaded tissue as demonstrated here will enable further studies of signal flow through cortical networks. ..
- Mühleisen T, Agoston Z, Schulte D. Retroviral misexpression of cVax disturbs retinal ganglion cell axon fasciculation and intraretinal pathfinding in vivo and guidance of nasal ganglion cell axons in vivo. Dev Biol. 2006;297:59-73 pubmed
- Erturk A, Hellal F, Enes J, Bradke F. Disorganized microtubules underlie the formation of retraction bulbs and the failure of axonal regeneration. J Neurosci. 2007;27:9169-80 pubmed..Our data pinpoint microtubules as a key regulatory target for axonal regeneration. ..
- Nave K, Trapp B. Axon-glial signaling and the glial support of axon function. Annu Rev Neurosci. 2008;31:535-61 pubmed publisher..Loss of glial support causes progressive axon degeneration and possibly local inflammation, both of which are likely to contribute to a variety of neuronal diseases in the central and peripheral nervous systems. ..
- Rose K, Schröer U, Volk G, Schlatt S, König S, Feigenspan A, et al. Axonal regeneration in the organotypically cultured monkey retina: biological aspects, dependence on substrates and age-related proteomic profiling. Restor Neurol Neurosci. 2008;26:249-66 pubmed..To our knowledge these data are the first from subhuman animals to suggest that axonal regeneration of injured RGCs is correlated to expression of identifiable proteins within the retina. ..
- Ohler S, Hakeda Suzuki S, Suzuki T. Hts, the Drosophila homologue of Adducin, physically interacts with the transmembrane receptor Golden goal to guide photoreceptor axons. Dev Dyn. 2011;240:135-48 pubmed publisher..Our results fit with a model where Gogo both positively and negatively regulates Hts that affects the Actin-Spectrin cytoskeleton in growth cone filopodia, thereby guiding R axons. ..
- Mann K, Wang M, Luu S, Ohler S, Hakeda Suzuki S, Suzuki T. A putative tyrosine phosphorylation site of the cell surface receptor Golden goal is involved in synaptic layer selection in the visual system. Development. 2012;139:760-71 pubmed publisher..We propose the model that a constant phosphorylation signal is antagonized by a presumably temporal dephosphorylation signal, which creates a permissive signal that controls developmental timing in axon targeting. ..
- Rossoll W, Jablonka S, Andreassi C, Kröning A, Karle K, Monani U, et al. Smn, the spinal muscular atrophy-determining gene product, modulates axon growth and localization of beta-actin mRNA in growth cones of motoneurons. J Cell Biol. 2003;163:801-12 pubmed..Together, these data suggest that a complex of Smn with its binding partner hnRNP R interacts with beta-actin mRNA and translocates to axons and growth cones of motoneurons. ..
- Tedeschi A, Nguyen T, Puttagunta R, Gaub P, Di Giovanni S. A p53-CBP/p300 transcription module is required for GAP-43 expression, axon outgrowth, and regeneration. Cell Death Differ. 2009;16:543-54 pubmed publisher..These data contribute to the understanding of gene regulation in axon outgrowth and may suggest new molecular targets for axon regeneration. ..
- Distel M, Hocking J, Volkmann K, Köster R. The centrosome neither persistently leads migration nor determines the site of axonogenesis in migrating neurons in vivo. J Cell Biol. 2010;191:875-90 pubmed publisher..These in vivo data reveal a new temporal orchestration of organelle dynamics and provide important insights into the variation in intracellular processes during vertebrate brain differentiation. ..
- Williams S, Fairless R, Weise J, Kalinke U, Schulz Schaeffer W, Diem R. Neuroprotective effects of the cellular prion protein in autoimmune optic neuritis. Am J Pathol. 2011;178:2823-31 pubmed publisher..Conversely, mice lacking PrP(C) demonstrated significantly more neurodegeneration. This suggests that PrP(C) may have a neuroprotective function independent of its role in regulating the immune response. ..
- Adams R, Betz H, Puschel A. A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis. Mech Dev. 1996;57:33-45 pubmed..The identification of semF and G increases the number of vertebrate semaphorins to at least 20 and suggests that some semaphorins might act as positive axonal guidance cues. ..
- Rozov A, Jerecic J, Sakmann B, Burnashev N. AMPA receptor channels with long-lasting desensitization in bipolar interneurons contribute to synaptic depression in a novel feedback circuit in layer 2/3 of rat neocortex. J Neurosci. 2001;21:8062-71 pubmed..It is concluded that in the local circuits between pyramidal and bipolar cells the desensitization of AMPARs in bipolar cells contributes to low-pass feedback inhibition of layer 2/3 pyramidal neurons by bipolar cells. ..
- Angelov D, Guntinas Lichius O, Wewetzer K, Neiss W, Streppel M. Axonal branching and recovery of coordinated muscle activity after transection of the facial nerve in adult rats. Adv Anat Embryol Cell Biol. 2005;180:1-130 pubmed..Although most of these manipulations do influence peripheral nerve regeneration to some extent, only the application of autologous olfactory mucosa yielded a major improvement, i.e., better function. ..
- Liedtke T, Schwamborn J, Schröer U, Thanos S. Elongation of axons during regeneration involves retinal crystallin beta b2 (crybb2). Mol Cell Proteomics. 2007;6:895-907 pubmed..The results suggest that neuronal crystallins constitute a novel class of neurite-promoting factors that likely operate through an autocrine mechanism and that they could be used in neurodegenerative diseases. ..
- Haupt C, Huber A. How axons see their way--axonal guidance in the visual system. Front Biosci. 2008;13:3136-49 pubmed
- Abdesselem H, Shypitsyna A, Solis G, Bodrikov V, Stuermer C. No Nogo66- and NgR-mediated inhibition of regenerating axons in the zebrafish optic nerve. J Neurosci. 2009;29:15489-98 pubmed publisher..Thus, not only was the NogoA-specific domain lost in fish, but Nogo66, the second inhibitory domain in mammals, and its signaling upon binding to NgR, was modified so that ZF-Nogo/RTN-4 does not impair axon regeneration. ..
- Kohl B, Fischer S, Groh J, Wessig C, Martini R. MCP-1/CCL2 modifies axon properties in a PMP22-overexpressing mouse model for Charcot-Marie-tooth 1A neuropathy. Am J Pathol. 2010;176:1390-9 pubmed publisher..Our data show that, in a CMT1A model, MCP-1/CCL2 activates nerve macrophages, mediates both axon damage and demyelination, and may thus be a promising target for therapeutic approaches. ..
- Reick C, Ellrichmann G, Thone J, Scannevin R, Saft C, Linker R, et al. Neuroprotective dimethyl fumarate synergizes with immunomodulatory interferon beta to provide enhanced axon protection in autoimmune neuroinflammation. Exp Neurol. 2014;257:50-6 pubmed publisher..Combination of IFN-? and DMF resulted in greater beneficial effects with improved tissue protection as compared to the respective monotherapies. Further combination studies of these safe therapies in human disease are warranted. ..
- Sutor B, Schmolke C, Teubner B, Schirmer C, Willecke K. Myelination defects and neuronal hyperexcitability in the neocortex of connexin 32-deficient mice. Cereb Cortex. 2000;10:684-97 pubmed..Thus, in the neocortex, lack of Cx32 correlates with myelination defects, alterations in intrinsic membrane properties and dysfunction of inhibitory synaptic transmission. ..
- Klinge P, Vafa M, Brinker T, Brandis A, Walter G, Stieglitz T, et al. Immunohistochemical characterization of axonal sprouting and reactive tissue changes after long-term implantation of a polyimide sieve electrode to the transected adult rat sciatic nerve. Biomaterials. 2001;22:2333-43 pubmed..It is concluded that the introduced flexible polyimide electrode is suitable for contacting peripheral nerves since it permits substantial neurite growth and offers excellent long-term stability. ..
- Schmidt H, Werner M, Heppenstall P, Henning M, Moré M, Kühbandner S, et al. cGMP-mediated signaling via cGKIalpha is required for the guidance and connectivity of sensory axons. J Cell Biol. 2002;159:489-98 pubmed..Our studies therefore reveal that cGMP signaling is important for axonal growth in vivo and in vitro. ..
- Henrich M, Haberberger R, Hempelmann G, Kummer W. Quantitative immunohistochemical investigation of the intrinsic vasodilator innervation of the guinea pig lingual artery. Auton Neurosci. 2003;103:72-82 pubmed..g. lung and pelvic organs. ..
- Rami A, Jansen S, Giesser I, Winckler J. Post-ischemic activation of caspase-3 in the rat hippocampus: evidence of an axonal and dendritic localisation. Neurochem Int. 2003;43:211-23 pubmed
- Tumani H, Hartung H, Hemmer B, Teunissen C, Deisenhammer F, Giovannoni G, et al. Cerebrospinal fluid biomarkers in multiple sclerosis. Neurobiol Dis. 2009;35:117-27 pubmed publisher..A brief update on possible CSF biomarkers that might reflect key pathological processes of MS such as inflammation, demyelination, neuroaxonal loss, gliosis and regeneration is provided. ..
- Franzdóttir S, Engelen D, Yuva Aydemir Y, Schmidt I, Aho A, Klämbt C. Switch in FGF signalling initiates glial differentiation in the Drosophila eye. Nature. 2009;460:758-61 pubmed publisher..These results disclose an evolutionarily conserved control mechanism of axonal wrapping, indicating that Drosophila might serve as a model to understand glial disorders in humans. ..
- Kohl B, Groh J, Wessig C, Wiendl H, Kroner A, Martini R. Lack of evidence for a pathogenic role of T-lymphocytes in an animal model for Charcot-Marie-Tooth disease 1A. Neurobiol Dis. 2010;38:78-84 pubmed publisher..We suggest that - in contrast to myelin phagocytosing macrophages - T-lymphocytes are not a promising target for treatment of CMT1A. ..
- Subramanian N, Wetzel A, Dombert B, Yadav P, Havlicek S, Jablonka S, et al. Role of Na(v)1.9 in activity-dependent axon growth in motoneurons. Hum Mol Genet. 2012;21:3655-67 pubmed publisher..Na(V)1.9 activation could therefore serve as a target for modulating axonal regeneration in motoneuron diseases such as SMA in which presynaptic activity of VGCCs is reduced. ..
- Angelov D, Neiss W, Gunkel A, Guntinas Lichius O, Stennert E. Axotomy induces intranuclear immunolocalization of neuron-specific enolase in facial and hypoglossal neurons of the rat. J Neurocytol. 1994;23:218-33 pubmed..It is first detected at 2 days post axotomy, reaches its maximum at 10-18 days post axotomy and is no longer evident 56 days following surgery.(ABSTRACT TRUNCATED AT 250 WORDS) ..