Genomes and Genes
Experts and Doctors on astrocytes in France
Publications106 found, 100 shown here
- Renner G, Janouskova H, Noulet F, Koenig V, Guerin E, BÃ¤r S, et al. Integrin Î±5Î²1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade glioma. Cell Death Differ. 2016;23:640-53 pubmed publisher..Importantly, our results suggest that high-grade glioma expressing high level of Î±5Î²1 integrin may benefit from associated therapies including integrin antagonists and repressors of survivin expression. ..
- GhÃ©zali G, Calvo C, Pillet L, Llense F, Ezan P, Pannasch U, et al. Connexin 30 controls astroglial polarization during postnatal brain development. Development. 2018;145: pubmed publisher..This study thus reveals that connexin 30 controls astroglial polarity during development. ..
- Horner K, Troadec J, Blanchard M, Dallaporta M, Pio J. Receptors for leptin in the otic labyrinth and the cochlear-vestibular nerve of guinea pig are modified in hormone-induced anorexia. Hear Res. 2010;270:48-55 pubmed publisher..Leptin disturbance might contribute to metabolic syndromes involving the audiovestibular system. ..
- Béchade C, Pascual O, Triller A, Bessis A. Nitric oxide regulates astrocyte maturation in the hippocampus: involvement of NOS2. Mol Cell Neurosci. 2011;46:762-9 pubmed publisher..Our results highlight a novel developmental role of NO and NOS2 in the differentiation of radial glia and the maturation of astrocytes. ..
- Barat E, Boisseau S, BouyssiÃ¨res C, Appaix F, Savasta M, Albrieux M. Subthalamic nucleus electrical stimulation modulates calcium activity of nigral astrocytes. PLoS ONE. 2012;7:e41793 pubmed publisher..These findings have major implications given the position of SNr in the basal ganglia network. ..
- Martineau M, Shi T, Puyal J, Knolhoff A, Dulong J, Gasnier B, et al. Storage and uptake of D-serine into astrocytic synaptic-like vesicles specify gliotransmission. J Neurosci. 2013;33:3413-23 pubmed publisher..We conclude that astrocytes contain vesicles capable of storing and releasing d-serine, l-glutamate, and most likely other neuromodulators in an activity-dependent manner. ..
- Araneda S, Mermet N, Verjat T, Angulo J, Radicella J. Expression of Kin17 and 8-OxoG DNA glycosylase in cells of rodent and quail central nervous system. Brain Res Bull. 2001;56:139-46 pubmed..Our results suggest that the expression of the Kin17 protein (observed in neurons) and that of the Ogg1 protein (observed in neurons and glial cells) is conserved in brain phylogeny. ..
- Ozden S, Seilhean D, Gessain A, Hauw J, Gout O. Severe demyelinating myelopathy with low human T cell lymphotropic virus type 1 expression after transfusion in an immunosuppressed patient. Clin Infect Dis. 2002;34:855-60 pubmed
- Mothet J, Pollegioni L, Ouanounou G, Martineau M, Fossier P, Baux G. Glutamate receptor activation triggers a calcium-dependent and SNARE protein-dependent release of the gliotransmitter D-serine. Proc Natl Acad Sci U S A. 2005;102:5606-11 pubmed..In summary, our study reveals the cellular mechanisms subserving D-serine release and highlights the importance of the glial cell exocytotic pathway in influencing CNS levels of extracellular D-serine. ..
- Dufour C, Cadusseau J, Varlet P, Surena A, de Faria G, Dias Morais A, et al. Astrocytes reverted to a neural progenitor-like state with transforming growth factor alpha are sensitized to cancerous transformation. Stem Cells. 2009;27:2373-82 pubmed publisher..These results demonstrate that reversion of mature astrocytes to an embryonic state without genomic manipulation is sufficient to sensitize them to oncogenic stress. ..
- Li T, Bourgeois J, Celli S, Glacial F, Le Sourd A, Mécheri S, et al. Cell-penetrating anti-GFAP VHH and corresponding fluorescent fusion protein VHH-GFP spontaneously cross the blood-brain barrier and specifically recognize astrocytes: application to brain imaging. FASEB J. 2012;26:3969-79 pubmed publisher..3) of the fusion protein VHH-GFP was able to cross the BBB and to label astrocytes in vivo. The potential of VHHs as diagnostic or therapeutic agents in the central nervous system now deserves attention. ..
- Housset M, Samuel A, Ettaiche M, Bemelmans A, Beby F, Billon N, et al. Loss of Otx2 in the adult retina disrupts retinal pigment epithelium function, causing photoreceptor degeneration. J Neurosci. 2013;33:9890-904 pubmed publisher..These findings thus provide novel general markers for clinical detection and prevention of neuronal cell death. ..
- Palombo M, Ligneul C, Najac C, Le Douce J, Flament J, Escartin C, et al. New paradigm to assess brain cell morphology by diffusion-weighted MR spectroscopy in vivo. Proc Natl Acad Sci U S A. 2016;113:6671-6 pubmed publisher..This work suggests that the time dependence of metabolite diffusion coefficient allows distinguishing and quantitatively characterizing brain cell morphologies noninvasively. ..
- Lamirand A, Ramauge M, Pierre M, Courtin F. Bacterial lipopolysaccharide induces type 2 deiodinase in cultured rat astrocytes. J Endocrinol. 2011;208:183-92 pubmed publisher..Our observations, which demonstrate D2 induction by LPS in astrocytes and specify some characteristics of D2 induction mechanism, support the possible implication of brain D2 in adaptative responses to an infectious stress. ..
- Cassé F, Bardou I, Danglot L, Briens A, Montagne A, Parcq J, et al. Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals. J Neurosci. 2012;32:5186-99 pubmed publisher..Overall, this work provides the first demonstration that the neuromodulator, tPA, may also be considered as a gliotransmitter. ..
- De Seranno S, Estrella C, Loyens A, Cornea A, Ojeda S, Beauvillain J, et al. Vascular endothelial cells promote acute plasticity in ependymoglial cells of the neuroendocrine brain. J Neurosci. 2004;24:10353-63 pubmed
- Collombet J, Four E, Bernabé D, Masqueliez C, Burckhart M, Baille V, et al. Soman poisoning increases neural progenitor proliferation and induces long-term glial activation in mouse brain. Toxicology. 2005;208:319-34 pubmed..This increased proliferation rate was detected up to 1 month after poisoning. ..
- Collombet J, Four E, Burckhart M, Masqueliez C, Bernabé D, Baubichon D, et al. Effect of cytokine treatment on the neurogenesis process in the brain of soman-poisoned mice. Toxicology. 2005;210:9-23 pubmed..Interestingly, the administration of cytokines resulted in the differentiation of BrdU-positive cells into new neurons in the CA1 hippocampal layer, whereas astrocytic differentiation was preferentially observed in the amygdala. ..
- Laux A, Delalande F, Mouheiche J, Stuber D, Van Dorsselaer A, Bianchi E, et al. Localization of endogenous morphine-like compounds in the mouse spinal cord. J Comp Neurol. 2012;520:1547-61 pubmed publisher..Our study demonstrates the possibility that endogenous morphine-like compounds in the central nervous system have other functions beyond their analgesic functions. ..
- McGuckin C, Jurga M, Miller A, Sarnowska A, Wiedner M, Boyle N, et al. Ischemic brain injury: a consortium analysis of key factors involved in mesenchymal stem cell-mediated inflammatory reduction. Arch Biochem Biophys. 2013;534:88-97 pubmed publisher..Our study paves the way to preclinical stages of a clinical trial with hMSC, and suggests a non-canonical JAK-STAT signaling of unphosphorylated STAT3 in immunomodulatory effects of hMSCs. ..
- Alonso G, Runquist M, Hussy N, Duvoid A, Moos F. Age-related modifications of the morphological organization of pituicytes are associated with alteration of the GABAergic and dopaminergic innervation afferent to the neurohypophysial lobe. Eur J Neurosci. 2003;18:1889-903 pubmed..Taken together, these data suggest that the age-related morphological changes of pituicytes result from the alteration of the GABA/DAergic innervation of the NL. ..
- Champeil Potokar G, Denis I, Goustard Langelier B, Alessandri J, Guesnet P, Lavialle M. Astrocytes in culture require docosahexaenoic acid to restore the n-3/n-6 polyunsaturated fatty acid balance in their membrane phospholipids. J Neurosci Res. 2004;75:96-106 pubmed..This reliable method of altering membrane phospholipid composition promises to be useful for studying the influence of n-6/n-3 imbalance on astrocyte function. ..
- Hebert G, Mingam R, Arsaut J, Dantzer R, Demotes Mainard J. Cellular distribution of interleukin-1alpha-immunoreactivity after MPTP intoxication in mice. Brain Res Mol Brain Res. 2005;138:156-63 pubmed..In the striatum, IL-1alpha-ir was also detected in a non-astrocytic perivascular component, with a distribution similar to GAP-43-ir. IL-1alpha could thus directly or indirectly influence striatal reorganization after MPTP. ..
- Espallergues J, Solovieva O, Técher V, Bauer K, Alonso G, Vincent A, et al. Synergistic activation of astrocytes by ATP and norepinephrine in the rat supraoptic nucleus. Neuroscience. 2007;148:712-23 pubmed
- Blanchin S, Coffin C, Viader F, Ruf J, Carayon P, Potier F, et al. Anti-thyroperoxidase antibodies from patients with Hashimoto's encephalopathy bind to cerebellar astrocytes. J Neuroimmunol. 2007;192:13-20 pubmed..Normal human astrocytes from primary cultures also reacted with anti-TPO mAb. Specific astrocyte binding of anti-TPO aAb suggests a role of these aAb in the HE pathogenesis. ..
- Pernot F, Carpentier P, Baille V, Testylier G, Beaup C, Foquin A, et al. Intrahippocampal cholinesterase inhibition induces epileptogenesis in mice without evidence of neurodegenerative events. Neuroscience. 2009;162:1351-65 pubmed publisher..Our data show that focal hypercholinergy may be a sufficient initial event to promote epilepsy and that major brain tissue changes (cellular damage, edema, neuroinflammation) are not necessary conditions. ..
- Cronier S, Carimalo J, Schaeffer B, Jaumain E, Beringue V, Miquel M, et al. Endogenous prion protein conversion is required for prion-induced neuritic alterations and neuronal death. FASEB J. 2012;26:3854-61 pubmed publisher..We suggest that active prion replication in neurons sensitizes them to environmental stress regulated by neighboring cells, including astrocytes. ..
- Tchoghandjian A, Fernandez C, Colin C, El Ayachi I, Voutsinos Porche B, Fina F, et al. Pilocytic astrocytoma of the optic pathway: a tumour deriving from radial glia cells with a specific gene signature. Brain. 2009;132:1523-35 pubmed publisher..Therefore, pilocytic astrocytomas of the hypothalamo-chiasmatic region should be considered as a distinct entity which probably originates from a unique population of cells with radial glia phenotype. ..
- Razafimanjato H, Garmy N, Guo X, Varini K, Di Scala C, Di Pasquale E, et al. The food-associated fungal neurotoxin ochratoxin A inhibits the absorption of glutamate by astrocytes through a decrease in cell surface expression of the excitatory amino-acid transporters GLAST and GLT-1. Neurotoxicology. 2010;31:475-84 pubmed publisher
- Chounlamountry K, Kessler J. The ultrastructure of perisynaptic glia in the nucleus tractus solitarii of the adult rat: Comparison between single synapses and multisynaptic arrangements. Glia. 2011;59:655-63 pubmed publisher..Especially, in multisynaptic arrangements, the lack of intervening glia may favor functional coupling between individual contacts. ..
- Camand E, Peglion F, Osmani N, Sanson M, Etienne Manneville S. N-cadherin expression level modulates integrin-mediated polarity and strongly impacts on the speed and directionality of glial cell migration. J Cell Sci. 2012;125:844-57 pubmed publisher..Re-expression of N-cadherin in gliomas restores cell polarity and strongly reduces cell velocity, suggesting that loss of N-cadherin could contribute to the invasive capacity of tumour astrocytes. ..
- Victoria G, Arkhipenko A, Zhu S, Syan S, Zurzolo C. Astrocyte-to-neuron intercellular prion transfer is mediated by cell-cell contact. Sci Rep. 2016;6:20762 pubmed publisher..Because of their role in intercellular transfer of prions astrocytes may influence progression of the disease. ..
- Franceschini I, Feigenbaum Lacombe V, Casanova P, Lopez Lastra M, Darlix J, Dalcq M. Efficient gene transfer in mouse neural precursors with a bicistronic retroviral vector. J Neurosci Res. 2001;65:208-19 pubmed
- Banisadr G, Skrzydelski D, Kitabgi P, Rostene W, Parsadaniantz S. Highly regionalized distribution of stromal cell-derived factor-1/CXCL12 in adult rat brain: constitutive expression in cholinergic, dopaminergic and vasopressinergic neurons. Eur J Neurosci. 2003;18:1593-606 pubmed..In addition, a key role for SDF-1/CXCL12 in neuroendocrine regulation of vasopressin-expressing neurons represents an exciting new field of research. ..
- DelÃ©pine C, Meziane H, Nectoux J, Opitz M, Smith A, Ballatore C, et al. Altered microtubule dynamics and vesicular transport in mouse and human MeCP2-deficient astrocytes. Hum Mol Genet. 2016;25:146-57 pubmed publisher..These findings represent a first step toward the validation of an innovative treatment for RTT. ..
- Bouchard P, Ravet V, Meiniel R, Creveaux I, Meiniel A, Vellet A, et al. Use of a heterologous monoclonal antibody for cloning and detection of glial fibrillary acidic protein in the bovine ventricular ependyma. Cell Tissue Res. 1999;298:207-16 pubmed..Using MAb E501 as a heterologous probe, we cloned bovine GFAP cDNA. In situ hybridization experiments failed to detect GFAP transcripts in SCO ependymocytes, confirming the abscence of immunoreactivity in these cells. ..
- Lesne S, Blanchet S, Docagne F, Liot G, Plawinski L, Mackenzie E, et al. Transforming growth factor-beta1-modulated cerebral gene expression. J Cereb Blood Flow Metab. 2002;22:1114-23 pubmed..The authors' observations enlarge the repertoire of known TGF-beta1-modulated genes and their possible involvement in neurodegenerative processes. ..
- Bienvenu G, Seurin D, Grellier P, Froment P, Baudrimont M, Monget P, et al. Insulin-like growth factor binding protein-6 transgenic mice: postnatal growth, brain development, and reproduction abnormalities. Endocrinology. 2004;145:2412-20 pubmed..Our results indicate that this new model of transgenic mouse may prove to be a useful tool in elucidating the in vivo role of IGFBP-6 in the brain, especially in regard to hypothalamic control, and in reproductive physiology. ..
- Grenier J, Trousson A, Chauchereau A, Cartaud J, Schumacher M, Massaad C. Differential recruitment of p160 coactivators by glucocorticoid receptor between Schwann cells and astrocytes. Mol Endocrinol. 2006;20:254-67 pubmed..Altogether, these results highlight the cell specificity and the time dependence of p160s recruitment by the activated GR in glial cells, revealing the complexity of GR-p160 assembly in the nervous system. ..
- Deiva K, Khiati A, Hery C, Salim H, Leclerc P, Horellou P, et al. CCR5-, DC-SIGN-dependent endocytosis and delayed reverse transcription after human immunodeficiency virus type 1 infection in human astrocytes. AIDS Res Hum Retroviruses. 2006;22:1152-61 pubmed..Astrocytes express DC-SIGN and HIV-1 penetrates into these cells through CCR5- and/or DCSIGN- mediated endocytosis, via a pH-dependent pathway, with a delayed reverse transcription after infection without productive infection. ..
- Lortet S, Canolle B, Masmejean F, Nieoullon A. Plasma membrane expression of the neuronal glutamate transporter EAAC1 is regulated by glial factors: evidence for different regulatory pathways associated with neuronal maturation. Neurochem Int. 2008;52:1373-82 pubmed publisher..These different regulatory pathways of EAAC1 are associated with different neuronal maturation stages. ..
- Clasadonte J, Poulain P, Hanchate N, Corfas G, Ojeda S, Prevot V. Prostaglandin E2 release from astrocytes triggers gonadotropin-releasing hormone (GnRH) neuron firing via EP2 receptor activation. Proc Natl Acad Sci U S A. 2011;108:16104-9 pubmed publisher..These results indicate that astrocyte-to-neuron communication in the hypothalamus is essential for the activity of GnRH neurons and suggest that PGE(2) acts as a gliotransmitter within the GnRH neurosecretory system. ..
- Kinugawa K, Monnet Y, Lu L, Bekaert A, Thery C, Mallat Z, et al. MFGE8 does not orchestrate clearance of apoptotic neurons in a mouse model of Parkinson's disease. Neurobiol Dis. 2013;51:192-201 pubmed publisher..In summary, our data argue that MFGE8 is not likely involved in the phagocytic clearance of neuronal debris associated with nigrostriatal pathway injury. ..
- Laux Biehlmann A, Mouheiche J, Vérièpe J, Goumon Y. Endogenous morphine and its metabolites in mammals: history, synthesis, localization and perspectives. Neuroscience. 2013;233:95-117 pubmed publisher..The present review describes endogenous morphine and morphine derivative discovery, synthesis, localization and potential implications in physiological and pathological processes...
- Verge V, Hevor T. Regulation of fructose-1,6-bisphosphatase activity in primary cultured astrocytes. Neurochem Res. 1995;20:1049-56 pubmed..Potassium ions also stimulated fructose-1,6-bisphosphatase activity.(ABSTRACT TRUNCATED AT 250 WORDS) ..
- Estelles A, Yokoyama M, Nothias F, Vincent J, Glowinski J, Vernier P, et al. The major astrocytic phosphoprotein PEA-15 is encoded by two mRNAs conserved on their full length in mouse and human. J Biol Chem. 1996;271:14800-6 pubmed
- Agassandian C, Plantier M, Fattoum A, Represa A, Der Terrossian E. Subcellular distribution of calponin and caldesmon in rat hippocampus. Brain Res. 2000;887:444-9 pubmed..Finally, while caldesmon seems strictly distributed to neurones, acidic calponin is present in both neurones and astrocytes. ..
- Rivera S, Ogier C, Jourquin J, Timsit S, Szklarczyk A, Miller K, et al. Gelatinase B and TIMP-1 are regulated in a cell- and time-dependent manner in association with neuronal death and glial reactivity after global forebrain ischemia. Eur J Neurosci. 2002;15:19-32 pubmed
- Konig N, Raynaud F, Feane H, Durand M, Mestre Frances N, Rossel M, et al. Calpain 3 is expressed in astrocytes of rat and Microcebus brain. J Chem Neuroanat. 2003;25:129-36 pubmed..Other immunoreactive cells were found close to the pial surface of the forebrain, in the corpus callosum and in the dentate gyrus. Calpain 3 may be involved in astrocyte plasticity and/or motility. ..
- Friocourt G, Koulakoff A, Chafey P, Boucher D, Fauchereau F, Chelly J, et al. Doublecortin functions at the extremities of growing neuronal processes. Cereb Cortex. 2003;13:620-6 pubmed..The observations summarized here favor the suggestion that whereas LIS1 may play a role in nuclear migration, Doublecortin is instead restricted to functions at the leading edge of the cell. ..
- Menet V, Prieto M, Privat A, Gimenez y Ribotta M. Axonal plasticity and functional recovery after spinal cord injury in mice deficient in both glial fibrillary acidic protein and vimentin genes. Proc Natl Acad Sci U S A. 2003;100:8999-9004 pubmed
- Hachem S, Aguirre A, Vives V, Marks A, Gallo V, Legraverend C. Spatial and temporal expression of S100B in cells of oligodendrocyte lineage. Glia. 2005;51:81-97 pubmed
- Gautron L, De Smedt Peyrusse V, Layé S. Characterization of STAT3-expressing cells in the postnatal rat brain. Brain Res. 2006;1098:26-32 pubmed..In summary, our study reveals a complex regulation of STAT3 phosphorylation in the postnatal brain and provides in vivo evidence of the specific expression of STAT3 in maturating astrocytes and brainstem motoneurons. ..
- Brillaud E, Piotrowski A, de Seze R. Effect of an acute 900MHz GSM exposure on glia in the rat brain: a time-dependent study. Toxicology. 2007;238:23-33 pubmed..We conclude to a temporary effect, probably due to a hypertrophy of glial cells, with a temporal and a spatial modulation of the effect. Whether this effect could be harmful remains to be studied. ..
- Pascual O, Ben Achour S, Rostaing P, Triller A, Bessis A. Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission. Proc Natl Acad Sci U S A. 2012;109:E197-205 pubmed publisher..Because pathological activation of microglia and alteration of neurotransmission are two early symptoms of most brain diseases, our work also provides a basis for understanding synaptic dysfunction in neuronal diseases. ..
- Cazaubon S, Ramos Morales F, Fischer S, Schweighoffer F, Strosberg A, Couraud P. Endothelin induces tyrosine phosphorylation and GRB2 association of Shc in astrocytes. J Biol Chem. 1994;269:24805-9 pubmed..In conclusion, the Shc-Grb2 complex may be involved in the activation of the MAPK pathway, not only by several receptor tyrosine kinases but also by heterotrimeric G protein-coupled receptors, such as ET-1 receptors. ..
- Lannuzel A, Barnier J, Hery C, Huynh V, Guibert B, Gray F, et al. Human immunodeficiency virus type 1 and its coat protein gp120 induce apoptosis and activate JNK and ERK mitogen-activated protein kinases in human neurons. Ann Neurol. 1997;42:847-56 pubmed..This demonstrates that gp120 could be an effector of HIV-1-induced apoptosis in the CNS and act directly on neuronal and glial cells. ..
- Peneff C, Ferrari P, Charrier V, Taburet Y, Monnier C, Zamboni V, et al. Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture. EMBO J. 2001;20:6191-202 pubmed
- Jauneau A, Ischenko A, Chan P, Fontaine M. Complement component anaphylatoxins upregulate chemokine expression by human astrocytes. FEBS Lett. 2003;537:17-22 pubmed..Thus, anaphylatoxins could initiate a chemokine cascade and, at least in part, be involved in pathogenesis of the brain. ..
- Didier N, Romero I, Creminon C, Wijkhuisen A, Grassi J, Mabondzo A. Secretion of interleukin-1beta by astrocytes mediates endothelin-1 and tumour necrosis factor-alpha effects on human brain microvascular endothelial cell permeability. J Neurochem. 2003;86:246-54 pubmed..Taken together, these results provide evidence for paracrine actions involving ET-1, TNF-alpha and IL-1beta between human astrocytes and BMVECs, which may play a central role in BBB breakdown during CNS inflammation. ..
- Plachez C, Martin A, Guiramand J, Recasens M. Astrocytes repress the neuronal expression of GLAST and GLT glutamate transporters in cultured hippocampal neurons from embryonic rats. Neurochem Int. 2004;45:1113-23 pubmed..The repression of neuronal GLT expression probably results from glia-neuron interactions. This further reinforces the fundamental role of direct or indirect neuron-glia interactions in the development of the central nervous system. ..
- Sergent Tanguy S, Veziers J, Bonnamain V, Boudin H, Neveu I, Naveilhan P. Cell surface antigens on rat neural progenitors and characterization of the CD3 (+)/CD3 (-) cell populations. Differentiation. 2006;74:530-41 pubmed..The results reveal particular surface antigen profiles, giving new perspectives on the properties of rat brain-derived cells. ..
- Alfonsi F, Filippi P, Salaün D, Delapeyrière O, Durbec P. LIFR beta plays a major role in neuronal identity determination and glial differentiation in the mouse facial nucleus. Dev Biol. 2008;313:267-78 pubmed..We also show that LIFR beta is implicated in astrocyte and oligodendrocyte differentiation, specifically within the facial nucleus. ..
- Tixier E, Leconte C, Touzani O, Roussel S, Petit E, Bernaudin M. Adrenomedullin protects neurons against oxygen glucose deprivation stress in an autocrine and paracrine manner. J Neurochem. 2008;106:1388-403 pubmed publisher..Altogether, our results suggest that adrenomedullin is an effector of the hypoxic pre-conditioning-induced neuronal tolerance and a potent autocrine and paracrine neuroprotective factor during cerebral ischaemia. ..
- Pfrieger F, Ungerer N. Cholesterol metabolism in neurons and astrocytes. Prog Lipid Res. 2011;50:357-71 pubmed publisher..We conclude that an understanding of cholesterol metabolism in the brain and its role in disease requires a close look at individual cell types...
- Clarion L, Jacquard C, Sainte Catherine O, Loiseau S, Filippini D, Hirlemann M, et al. Oxaphosphinanes: new therapeutic perspectives for glioblastoma. J Med Chem. 2012;55:2196-211 pubmed publisher..1a is devoid of astrocyte toxicity. The original activity spectrum of 3.1a on the NCI cancer cell line panel allows the development of this family for use in association with existing drugs, opening new therapeutic perspectives...
- Saha B, Peron S, Murray K, Jaber M, Gaillard A. Cortical lesion stimulates adult subventricular zone neural progenitor cell proliferation and migration to the site of injury. Stem Cell Res. 2013;11:965-77 pubmed publisher..These data provide a detailed account of the changes occurring in the SVZ and the cortex following lesion, and indicate the potential of the endogenous neural progenitors in cortical repair. ..
- Leprince J, Gandolfo P, Thoumas J, Patte C, Fauchere J, Vaudry H, et al. Structure-activity relationships of a series of analogues of the octadecaneuropeptide ODN on calcium mobilization in rat astrocytes. J Med Chem. 1998;41:4433-8 pubmed
- Mercier C, Masseguin C, Roux F, Gabrion J, Scherrmann J. Expression of P-glycoprotein (ABCB1) and Mrp1 (ABCC1) in adult rat brain: focus on astrocytes. Brain Res. 2004;1021:32-40 pubmed..These findings provide new insights into the cerebral distribution of two ABC transporters linked to multidrug resistance (MDR). ..
- Osmani N, Vitale N, Borg J, Etienne Manneville S. Scrib controls Cdc42 localization and activity to promote cell polarization during astrocyte migration. Curr Biol. 2006;16:2395-405 pubmed..By interacting with betaPIX, Scrib controls localization and activation of the small GTPase Cdc42 and regulates Cdc42-dependent polarization pathways. ..
- Fonte C, Trousson A, Grenier J, Schumacher M, Massaad C. Opposite effects of CBP and p300 in glucocorticoid signaling in astrocytes. J Steroid Biochem Mol Biol. 2007;104:220-7 pubmed..Moreover, in astrocytes the opposite effects of CBP and p300 could lead to a balance in the transactivation potency of the GR, in order to fine tune the action of glucocorticoids. ..
- Candela P, Gosselet F, Miller F, Buee Scherrer V, Torpier G, Cecchelli R, et al. Physiological pathway for low-density lipoproteins across the blood-brain barrier: transcytosis through brain capillary endothelial cells in vitro. Endothelium. 2008;15:254-64 pubmed publisher..These results could provide clues to physiological functions of caveolae-caveosome transcellular pathway in brain capillary ECs and may help in the rational design of more effective therapeutic drugs to the brain. ..
- Dupin I, Sakamoto Y, Etienne Manneville S. Cytoplasmic intermediate filaments mediate actin-driven positioning of the nucleus. J Cell Sci. 2011;124:865-72 pubmed publisher..This function of intermediate filaments might be crucial for regulating cell motility, in particular in tumor cells expressing high levels of cytoplasmic intermediate filaments...
- Razafimanjato H, Benzaria A, Taïeb N, Guo X, Vidal N, Di Scala C, et al. The ribotoxin deoxynivalenol affects the viability and functions of glial cells. Glia. 2011;59:1672-83 pubmed publisher..Our results suggest that environmental ribotoxins such as DON could, at low doses, cause modifications of brain homeostasis and possibly participate in the etiology of neurological diseases in which alterations of the glia are involved. ..
- Pannasch U, Sibille J, Rouach N. Dual electrophysiological recordings of synaptically-evoked astroglial and neuronal responses in acute hippocampal slices. J Vis Exp. 2012;:e4418 pubmed publisher..Furthermore, we describe how to isolate pharmacologically the synaptically-evoked astroglial currents. ..
- Gasque P, Ischenko A, Legoedec J, Mauger C, Schouft M, Fontaine M. Expression of the complement classical pathway by human glioma in culture. A model for complement expression by nerve cells. J Biol Chem. 1993;268:25068-74 pubmed..Glioma cell lines appear to be an efficient and convenient model for the analysis of complement expression in human astrocytic cells. ..
- Menet V, Gimenez y Ribotta M, Chauvet N, Drian M, Lannoy J, Colucci Guyon E, et al. Inactivation of the glial fibrillary acidic protein gene, but not that of vimentin, improves neuronal survival and neurite growth by modifying adhesion molecule expression. J Neurosci. 2001;21:6147-58 pubmed..To conclude, our results suggest that GFAP expression is able to modulate key biochemical properties of astrocytes that are implicated in their permissivity. ..
- Lesne S, Docagne F, Gabriel C, Liot G, Lahiri D, Buee L, et al. Transforming growth factor-beta 1 potentiates amyloid-beta generation in astrocytes and in transgenic mice. J Biol Chem. 2003;278:18408-18 pubmed..These results demonstrate that TGF-beta1 potentiates Abeta production in human astrocytes and may enhance the formation of plaques burden in the brain of Alzheimer's disease patients. ..
- Husson I, Rangon C, Lelievre V, Bemelmans A, Sachs P, Mallet J, et al. BDNF-induced white matter neuroprotection and stage-dependent neuronal survival following a neonatal excitotoxic challenge. Cereb Cortex. 2005;15:250-61 pubmed..Altogether, these data showed that BDNF neuroprotection against neonatal excitotoxicity is dependent upon the type of activated glutamate receptors, the lesion localization and the developmental stage. ..
- Khaddage A, Chambonniere M, Morrison A, Allard D, Dumollard J, Pasquier B, et al. Desmoplastic infantile ganglioglioma: a rare tumor with an unusual presentation. Ann Diagn Pathol. 2004;8:280-3 pubmed..One year after surgery follow-up magnetic resonance imaging did not show tumor progression...
- Ogier C, Bernard A, Chollet A, Le Diguardher T, Hanessian S, Charton G, et al. Matrix metalloproteinase-2 (MMP-2) regulates astrocyte motility in connection with the actin cytoskeleton and integrins. Glia. 2006;54:272-84 pubmed
- Balenci L, Saoudi Y, Grunwald D, Deloulme J, Bouron A, Bernards A, et al. IQGAP1 regulates adult neural progenitors in vivo and vascular endothelial growth factor-triggered neural progenitor migration in vitro. J Neurosci. 2007;27:4716-24 pubmed..We propose that VEGF synthesized by astrocytes could be involved in the guidance of neural progenitors to neurogenic niches and that IQGAP1 is an effector of the VEGF-dependent migratory signal. ..
- Alonso M, Ortega Perez I, Grubb M, Bourgeois J, Charneau P, Lledo P. Turning astrocytes from the rostral migratory stream into neurons: a role for the olfactory sensory organ. J Neurosci. 2008;28:11089-102 pubmed publisher..New neurons in the adult OB can therefore arise from different neurogenic areas that can be separately regulated. ..
- Marino P, Norreel J, Schachner M, Rougon G, Amoureux M. A polysialic acid mimetic peptide promotes functional recovery in a mouse model of spinal cord injury. Exp Neurol. 2009;219:163-74 pubmed publisher..Our data point to the unique features of a carbohydrate mimicking peptide, and support the notion that PSA can be considered as an important factor in recovery from spinal cord injury. ..
- Sbai O, Ould Yahoui A, Ferhat L, Gueye Y, Bernard A, Charrat E, et al. Differential vesicular distribution and trafficking of MMP-2, MMP-9, and their inhibitors in astrocytes. Glia. 2010;58:344-66 pubmed publisher..Our results suggest that these proteinases and their inhibitors use different pathways for trafficking and secretion for distinct astrocytic functions. ..
- Labombarda F, Meffre D, Delespierre B, Krivokapic Blondiaux S, Chastre A, Thomas P, et al. Membrane progesterone receptors localization in the mouse spinal cord. Neuroscience. 2010;166:94-106 pubmed publisher..It thus represents a first important step towards a new understanding of progesterone actions in the nervous system within a precise neuroanatomical context. ..
- Faideau M, Kim J, Cormier K, Gilmore R, Welch M, Auregan G, et al. In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects. Hum Mol Genet. 2010;19:3053-67 pubmed publisher..These findings suggest that the presence of mHtt in astrocytes alters glial glutamate transport capacity early in the disease process and may contribute to HD pathogenesis. ..