Experts and Doctors on aromatase in Sweden
Eriksson A, Lorentzon M, Vandenput L, Labrie F, Lindersson M, Syvanen A, et al
. Genetic variations in sex steroid-related genes as predictors of serum estrogen levels in men. J Clin Endocrinol Metab. 2009;94:1033-41 pubmed publisher
..In addition, this polymorphism was modestly associated with lumbar spine BMD (P < 0.01) and prevalent self-reported fractures (P < 0.05). rs2470152 of the CYP19 gene is clearly associated with serum E2 and E1 levels in men. ..
Mattsson A, Olsson J, Brunström B. Selective estrogen receptor alpha activation disrupts sex organ differentiation and induces expression of vitellogenin II and very low-density apolipoprotein II in Japanese quail embryos. Reproduction. 2008;136:175-86 pubmed publisher
SÃ¤fholm M, Jansson E, Fick J, Berg C. Molecular and histological endpoints for developmental reproductive toxicity in Xenopus tropicalis: Levonorgestrel perturbs anti-MÃ¼llerian hormone and progesterone receptor expression. Comp Biochem Physiol C Toxicol Pharmacol. 2016;181-182:9-18 pubmed publisher
..This new knowledge on sexual development in X. tropicalis is useful in the development of early life-stage endpoints for developmental reproductive toxicity. ..
Vehmas A, Adam M, Laajala T, KastenmÃ¼ller G, Prehn C, Rozman J, et al
. Liver lipid metabolism is altered by increased circulating estrogen to androgen ratio in male mouse. J Proteomics. 2016;133:66-75 pubmed publisher
..Furthermore, the plasma phospholipid profile reflects the changes in the liver lipid metabolism. ..
Baghaei F, Rosmond R, Landen M, Westberg L, Hellstrand M, Holm G, et al
. Phenotypic and genotypic characteristics of women in relation to personality traits. Int J Behav Med. 2003;10:365-78 pubmed
..It was concluded that a majority of women showed M type of personality traits, associated with normal hormones, somatic health, and a long microsatellite in the transactivating domain of the AR gene. ..
Shim G, Warner M, Kim H, Andersson S, Liu L, Ekman J, et al
. Aromatase-deficient mice spontaneously develop a lymphoproliferative autoimmune disease resembling Sjogren's syndrome. Proc Natl Acad Sci U S A. 2004;101:12628-33 pubmed
..These results reveal that estrogen deficiency results in a lymphoproliferative autoimmune disease resembling SS and suggest that estrogen might have clinical value in the prevention or treatment of this disease. ..
Lorentzon M, Swanson C, Eriksson A, Mellstrom D, Ohlsson C. Polymorphisms in the aromatase gene predict areal BMD as a result of affected cortical bone size: the GOOD study. J Bone Miner Res. 2006;21:332-9 pubmed
..One may speculate that affected CYP19 activity, resulting in altered testosterone levels during pubertal development, might contribute to the association between CYP19 polymorphisms and cortical bone size. ..
Barros R, Machado U, Warner M, Gustafsson J. Muscle GLUT4 regulation by estrogen receptors ERbeta and ERalpha. Proc Natl Acad Sci U S A. 2006;103:1605-8 pubmed
Ohlsson C, Hammarstedt A, Vandenput L, Saarinen N, Ryberg H, Windahl S, et al
. Increased adipose tissue aromatase activity improves insulin sensitivity and reduces adipose tissue inflammation in male mice. Am J Physiol Endocrinol Metab. 2017;313:E450-E462 pubmed publisher
..We propose that estrogen increases insulin sensitivity via a local effect in WAT on adiponectin expression, adipose tissue inflammation, and adipogenesis. ..