Experts and Doctors on arginine in Belgium


Locale: Belgium
Topic: arginine

Top Publications

  1. Crabeel M, De Rijcke M, Seneca S, Heimberg H, Pfeiffer I, Matisova A. Further definition of the sequence and position requirements of the arginine control element that mediates repression and induction by arginine in Saccharomyces cerevisiae. Yeast. 1995;11:1367-80 pubmed
    ..The new data suggest that the arginine repressor might inhibit transcription in an active process. ..
  2. Raes G, Noel W, Beschin A, Brys L, De Baetselier P, Hassanzadeh G. FIZZ1 and Ym as tools to discriminate between differentially activated macrophages. Dev Immunol. 2002;9:151-9 pubmed
    ..Finally, we show that these genes can be used to monitor the macrophage activation status without the need to obtain pure macrophage populations. ..
  3. Sleegers K, Brouwers N, Van Damme P, Engelborghs S, Gijselinck I, van der Zee J, et al. Serum biomarker for progranulin-associated frontotemporal lobar degeneration. Ann Neurol. 2009;65:603-9 pubmed publisher
  4. Blachier F, Mourtada A, Sener A, Malaisse W. Stimulus-secretion coupling of arginine-induced insulin release. Uptake of metabolized and nonmetabolized cationic amino acids by pancreatic islets. Endocrinology. 1989;124:134-41 pubmed
  5. Boeynaems S, Bogaert E, Michiels E, Gijselinck I, Sieben A, Jovičić A, et al. Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD. Sci Rep. 2016;6:20877 pubmed publisher
    ..These findings provide evidence for an important role for nucleocytoplasmic transport in the pathogenic mechanism of c9ALS/FTD. ..
  6. Massant J, Glansdorff N. Metabolic channelling of carbamoyl phosphate in the hyperthermophilic archaeon Pyrococcus furiosus: dynamic enzyme-enzyme interactions involved in the formation of the channelling complex. Biochem Soc Trans. 2004;32:306-9 pubmed
  7. Matagne V, Lebrethon M, Gerard A, Bourguignon J. Kainate/estrogen receptor involvement in rapid estradiol effects in vitro and intracellular signaling pathways. Endocrinology. 2005;146:2313-23 pubmed
  8. Xu J, Verstraete W. Evaluation of nitric oxide production by lactobacilli. Appl Microbiol Biotechnol. 2001;56:504-7 pubmed
    ..The metabolism of nitrate and L-arginine by the Lactobacillus cell suspensions was also studied. The possibility that NO and nitrite production by lactobacilli may be a potential probiotic trait is also discussed. ..
  9. Rimaux T, Rivière A, Hébert E, Mozzi F, Weckx S, De Vuyst L, et al. A putative transport protein is involved in citrulline excretion and re-uptake during arginine deiminase pathway activity by Lactobacillus sakei. Res Microbiol. 2013;164:216-25 pubmed publisher
    ..In conclusion, results indicated that the PTP gene may putatively encode a citrulline/ornithine antiporter. ..

More Information


  1. Stes E, Biondi S, Holsters M, Vereecke D. Bacterial and plant signal integration via D3-type cyclins enhances symptom development in the Arabidopsis-Rhodococcus fascians interaction. Plant Physiol. 2011;156:712-25 pubmed publisher
    ..Hence, the activated d-type cyclin/retinoblastoma/E2F transcription factor pathway integrates both external and internal hormonal signals, stimulating mitotic cell divisions and inducing pathological plant organogenesis. ..
  2. Bondue A, Jao S, Blanpain C, Parmentier M, LiWang P. Characterization of the role of the N-loop of MIP-1 beta in CCR5 binding. Biochemistry. 2002;41:13548-55 pubmed
  3. Crabeel M, Seneca S, Devos K, Glansdorff N. Arginine repression of the Saccharomyces cerevisiae ARG1 gene. Comparison of the ARG1 and ARG3 control regions. Curr Genet. 1988;13:113-24 pubmed
    ..Neither of these two regions are thus part of the primary repressor target site. In addition, in terms of post-transcriptional regulation, the latter result indicates that no sequence specificity is required in the RNA recognition step. ..
  4. Van Coster R, Gerlo E, Giardina T, Engelke U, Smet J, De Praeter C, et al. Aminoacylase I deficiency: a novel inborn error of metabolism. Biochem Biophys Res Commun. 2005;338:1322-6 pubmed
    ..The mutation was also detected in 5/161 controls. To exclude the possibility of a genetic polymorphism, protein expression studies were performed showing that the mutant protein had lost catalytic activity. ..
  5. Malfait F, Symoens S, De Backer J, Hermanns Le T, Sakalihasan N, Lapiere C, et al. Three arginine to cysteine substitutions in the pro-alpha (I)-collagen chain cause Ehlers-Danlos syndrome with a propensity to arterial rupture in early adulthood. Hum Mutat. 2007;28:387-95 pubmed
    ..This broadens the phenotypic range of nonglycine substitutions in collagen type I and has important implications for genetic counseling and follow-up of patients carrying this type of mutation. ..
  6. Caldara M, Minh P, Bostoen S, Massant J, Charlier D. ArgR-dependent repression of arginine and histidine transport genes in Escherichia coli K-12. J Mol Biol. 2007;373:251-67 pubmed
    ..In contrast, ArgR-mediated repression of P hisJ by inhibition of RNA polymerase binding appears to occur through topological changes of the promoter region. ..
  7. Van Geldre L, Timmermans J, Lefebvre R. L-citrulline recycling by argininosuccinate synthetase and lyase in rat gastric fundus. Eur J Pharmacol. 2002;455:149-60 pubmed
    ..Recycling of L-citrulline might play a role in providing sufficient amounts of nNOS substrate during long-lasting relaxations in gastric fundus after food intake...
  8. Vaneechoutte M, de Baere T, Nemec A, Musilek M, van der Reijden T, Dijkshoorn L. Reclassification of Acinetobacter grimontii Carr et al. 2003 as a later synonym of Acinetobacter junii Bouvet and Grimont 1986. Int J Syst Evol Microbiol. 2008;58:937-40 pubmed publisher
    ..These findings were corroborated for a second representative of the A. grimontii type strain, DSM 14968T. These data confirm that Acinetobacter grimontii is a later heterotypic synonym of Acinetobacter junii. ..
  9. Metzger K, Frémont M, Roelant C, De Meirleir K. Lower frequency of IL-17F sequence variant (His161Arg) in chronic fatigue syndrome patients. Biochem Biophys Res Commun. 2008;376:231-3 pubmed publisher
    ..A significantly lower frequency of the C allele was observed in the CFS population, suggesting that the His161Arg variant may confer protection against the disease. These results suggest a role of Th17 cells in the pathogenesis of CFS. ..
  10. Boonchird C, Messenguy F, Dubois E. Characterization of the yeast ARG5,6 gene: determination of the nucleotide sequence, analysis of the control region and of ARG5,6 transcript. Mol Gen Genet. 1991;226:154-66 pubmed
    ..Specific regulation involves two regions: one located between the putative TATA element and the transcriptional initiation site and the second between this site and the first ATG. ..
  11. Nuytinck L, Freund M, Lagae L, Pierard G, Hermanns Le T, De Paepe A. Classical Ehlers-Danlos syndrome caused by a mutation in type I collagen. Am J Hum Genet. 2000;66:1398-402 pubmed
    ..Our findings show that mutations in other fibrillar collagens can be causally involved in classical EDS and point to genetic heterogeneity of this disorder. ..
  12. Aizawa N, Igawa Y, Nishizawa O, Wyndaele J. Effects of nitric oxide on the primary bladder afferent activities of the rat with and without intravesical acrolein treatment. Eur Urol. 2011;59:264-71 pubmed publisher
    ..It has been suggested that nitric oxide (NO) affects the afferent pathways innervating the bladder. In addition, acrolein, a metabolite of cyclophosphamide, causes bladder hypersensitivity in rats...
  13. Meulemans A, Seneca S, Pribyl T, Smet J, Alderweirldt V, Waeytens A, et al. Defining the pathogenesis of the human Atp12p W94R mutation using a Saccharomyces cerevisiae yeast model. J Biol Chem. 2010;285:4099-109 pubmed publisher
    ..Instead, we provide evidence that the primary effect of the substitution is on the dynamic properties of Atp12p. ..
  14. Ulrix W, van Steen G, Aert R, Robben J, Volckaert G. Two Streptomyces lividans 66 transfer RNA genes with anticodons corresponding to serine (AGC) and arginine (CGU) codons. FEMS Microbiol Lett. 1993;109:213-7 pubmed
    ..The gene for tRNA(Arg) (CGU) is the first Streptomyces tRNA gene described so far which encodes the translation of a codon with uridine at the third (wobble) position. ..
  15. Damas J. Kallikrein, nitric oxide and the vascular responses of the submaxillary glands in rats exposed to heat. Arch Int Physiol Biochim Biophys. 1994;102:139-46 pubmed
    ..No increase in glandular weight and no swelling of the of the soft tissues were observed. After atropine, the weight of the glands increased and a swelling of the soft tissues appeared.(ABSTRACT TRUNCATED AT 250 WORDS)..
  16. Bercy J, Dubois E, Messenguy F. Regulation of arginine metabolism in Saccharomyces cerevisiae: expression of the three ARGR regulatory genes and cellular localization of their products. Gene. 1987;55:277-85 pubmed
    ..However, some data suggest that the ARGRIII protein could control ARGRI activity. ..
  17. Qiu H, Dubois E, Broen P, Messenguy F. Functional analysis of ARGRI and ARGRIII regulatory proteins involved in the regulation of arginine metabolism in Saccharomyces cerevisiae. Mol Gen Genet. 1990;222:192-200 pubmed
    ..Gene disruption of the ARGRIII gene impairs the growth of the mutant on rich medium, showing that ARGRIII has a pleiotropic role in the cell. ..
  18. Gielis J, Lin J, Wingler K, Van Schil P, Schmidt H, Moens A. Pathogenetic role of eNOS uncoupling in cardiopulmonary disorders. Free Radic Biol Med. 2011;50:765-76 pubmed publisher
  19. Van der Zee J, Pirici D, Van Langenhove T, Engelborghs S, Vandenberghe R, Hoffmann M, et al. Clinical heterogeneity in 3 unrelated families linked to VCP p.Arg159His. Neurology. 2009;73:626-32 pubmed publisher
    ..In contrast, the neuropathologic phenotype was consistent with FTLD-TDP type 4. ..
  20. De Leeuw F, Zhang T, Wauquier C, Huez G, Kruys V, Gueydan C. The cold-inducible RNA-binding protein migrates from the nucleus to cytoplasmic stress granules by a methylation-dependent mechanism and acts as a translational repressor. Exp Cell Res. 2007;313:4130-44 pubmed
    ..Altogether, our findings further reveal the diversity of mechanisms by which CIRP is regulated by environmental stresses and provide new insights into CIRP cytoplasmic function. ..
  21. Peeters E, Nguyen Le Minh P, Foulquié Moreno M, Charlier D. Competitive activation of the Escherichia coli argO gene coding for an arginine exporter by the transcriptional regulators Lrp and ArgP. Mol Microbiol. 2009;74:1513-26 pubmed publisher
    ..The repertoire of bacterial transcription regulation mechanisms is vast, but the competitive activation of a single promoter by two activator proteins as described here appears to be rare. ..
  22. Massant J, Peeters E, Charlier D, Maes D. Crystallization and preliminary X-ray diffraction analysis of the arginine repressor of the hyperthermophile Thermotoga neapolitana. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006;62:26-8 pubmed
    ..73, b = 134.15, c = 139.31 A. Crystals of the repressor in the presence of its corepressor arginine diffracted to a resolution of 2.4 A and belong to the same space group, with similar unit-cell parameters...
  23. De Keersmaeker S, Van Mellaert L, Schaerlaekens K, Van Dessel W, Vrancken K, Lammertyn E, et al. Structural organization of the twin-arginine translocation system in Streptomyces lividans. FEBS Lett. 2005;579:797-802 pubmed
    ..In the cytoplasm, TatA and TatB were detected as monomer or as homo-oligomeric complexes...
  24. Lefebvre R, Baert E, Barbier A. Influence of NG-nitro-L-arginine on non-adrenergic non-cholinergic relaxation in the guinea-pig gastric fundus. Br J Pharmacol. 1992;106:173-9 pubmed
    ..6. These results suggest that NO is involved in NANC neurotransmission of the guinea-pig gastric fundus; its contribution to sustained NANC relaxation in the guinea-pig gastric fundus is much more important than in the rat...
  25. D Hooge R, Marescau B, Qureshi I, De Deyn P. Impaired cognitive performance in ornithine transcarbamylase-deficient mice on arginine-free diet. Brain Res. 2000;876:1-9 pubmed
    ..We conclude that cognitive performance is impaired in spf mice as a consequence of Arg(-) diet-induced neurochemical alterations. ..
  26. Van Huffel C, Dubois E, Messenguy F. Cloning and sequencing of arg3 and arg11 genes of Schizosaccharomyces pombe on a 10-kb DNA fragment. Heterologous expression and mitochondrial targeting of their translation products. Eur J Biochem. 1992;205:33-43 pubmed
    ..cerevisiae did not allow its localization. The promoters of S. pombe arg3 and arg11 genes do not present striking similarities among themselves nor with the promoters of the equivalent genes of S. cerevisiae. ..
  27. Vanhoof G, De Meester I, Goossens F, Hendriks D, Scharpe S, Yaron A. Kininase activity in human platelets: cleavage of the Arg1-Pro2 bond of bradykinin by aminopeptidase P. Biochem Pharmacol. 1992;44:479-87 pubmed
    ..Cu2+, Zn2+ and Hg2+ are strongly inhibitory. Inhibition by cysteine protease inhibitors suggests the presence of a thiol group essential for enzymatic activity. Serine protease inhibitors do not affect the enzyme activity. ..
  28. Marescau B, De Deyn P, Lowenthal A, Qureshi I, Antonozzi I, Bachmann C, et al. Guanidino compound analysis as a complementary diagnostic parameter for hyperargininemia: follow-up of guanidino compound levels during therapy. Pediatr Res. 1990;27:297-303 pubmed
    ..Thus, guanidino compound analyses can be used as a complementary biochemical diagnostic parameter for hyperargininemia. Although the argininemia can be normalized by therapy, the levels of the catabolites of arginine are still elevated...
  29. Vercammen D, van de Cotte B, De Jaeger G, Eeckhout D, Casteels P, Vandepoele K, et al. Type II metacaspases Atmc4 and Atmc9 of Arabidopsis thaliana cleave substrates after arginine and lysine. J Biol Chem. 2004;279:45329-36 pubmed
    ..These findings suggest that type II metacaspases are not directly responsible for earlier reported caspase-like activities in plants. ..
  30. Abadjieva A, Pauwels K, Hilven P, Crabeel M. A new yeast metabolon involving at least the two first enzymes of arginine biosynthesis: acetylglutamate synthase activity requires complex formation with acetylglutamate kinase. J Biol Chem. 2001;276:42869-80 pubmed
    ..Hypotheses regarding the biological significance of this interaction are discussed. ..
  31. Missiaen L, Vanoevelen J, Parys J, Raeymaekers L, De Smedt H, Callewaert G, et al. Ca2+ uptake and release properties of a thapsigargin-insensitive nonmitochondrial Ca2+ store in A7r5 and 16HBE14o- cells. J Biol Chem. 2002;277:6898-902 pubmed
    ..In conclusion, A7r5 and 16HBE14o- cells express a Pmr1-containing Ca(2+) store with properties that differ substantially from the SERCA-containing Ca(2+) store...
  32. Dhaese P, De Greve H, Gielen J, Seurinck L, Van Montagu M, Schell J. Identification of sequences involved in the polyadenylation of higher plant nuclear transcripts using Agrobacterium T-DNA genes as models. EMBO J. 1983;2:419-26 pubmed
    ..Three other sites are located within the adjacent plant DNA, giving rise to hybrid T-DNA/plant DNA transcripts. The two most distal sites are probably dependent on a motif AATAAATAAA, found 29 bp away from the T-DNA/plant DNA junction...
  33. Pauwels K, Abadjieva A, Hilven P, Stankiewicz A, Crabeel M. The N-acetylglutamate synthase/N-acetylglutamate kinase metabolon of Saccharomyces cerevisiae allows co-ordinated feedback regulation of the first two steps in arginine biosynthesis. Eur J Biochem. 2003;270:1014-24 pubmed
    ..We conclude that the NAGS/NAGK metabolon promotes the co-ordination of the catalytic activities and feedback regulation of the first two, flux controlling, enzymes of the arginine pathway. ..
  34. Ammar N, Nelis E, Merlini L, Barisic N, Amouri R, Ceuterick C, et al. Identification of novel GDAP1 mutations causing autosomal recessive Charcot-Marie-Tooth disease. Neuromuscul Disord. 2003;13:720-8 pubmed
  35. Charlier D. Arginine regulation in Thermotoga neapolitana and Thermotoga maritima. Biochem Soc Trans. 2004;32:310-3 pubmed
    ..Thus, its DNA-binding activity is nearly arginine-independent and exhibits poor sequence specificity. ArgR(Tn) has a remarkable capacity to bind heterologous arginine operators and half-site targets. ..
  36. Henquin J, Nenquin M, Szollosi A, Kubosaki A, Notkins A. Insulin secretion in islets from mice with a double knockout for the dense core vesicle proteins islet antigen-2 (IA-2) and IA-2beta. J Endocrinol. 2008;196:573-81 pubmed publisher
    ..In conclusion, IA-2 and IA-2beta are dispensable for exocytosis of insulin granules, but are probably more important for cargo loading and/or stability of dense core vesicles. ..
  37. Xu Y, Sun Y, Huysveld N, Gigot D, Glansdorff N, Charlier D. Regulation of arginine biosynthesis in the psychropiezophilic bacterium Moritella profunda: in vivo repressibility and in vitro repressor-operator contact probing. J Mol Biol. 2003;326:353-69 pubmed
    ..A close inspection of sequence conservation and of single base-pair O(c)-type mutations indicate that the same conclusion can be generalized to E.coli operators...
  38. Amar N, Messenguy F, El Bakkoury M, Dubois E. ArgRII, a component of the ArgR-Mcm1 complex involved in the control of arginine metabolism in Saccharomyces cerevisiae, is the sensor of arginine. Mol Cell Biol. 2000;20:2087-97 pubmed
  39. Crabeel M, Soetens O, De Rijcke M, Pratiwi R, Pankiewicz R. The ARG11 gene of Saccharomyces cerevisiae encodes a mitochondrial integral membrane protein required for arginine biosynthesis. J Biol Chem. 1996;271:25011-8 pubmed
    ..Arg11p thus appears to fulfill a partially redundant function requiring its 27 carboxyl-terminal amino acids. As a working hypothesis, we propose that Arg11p participates in the export of matrix-made ornithine into the cytosol. ..
  40. Van Huffel C, Dubois E, Messenguy F. Cloning and sequencing of Schizosaccharomyces pombe car1 gene encoding arginase. Expression of the arginine anabolic and catabolic genes in response to arginine and related metabolites. Yeast. 1994;10:923-33 pubmed
    ..cerevisiae, and also indicates that in S. pombe enzyme compartmentation is not always sufficient to control the arginine metabolic flux. ..
  41. Heimberg H, Boyen A, Crabeel M, Glansdorff N. Escherichia coli and Saccharomyces cerevisiae acetylornithine aminotransferase: evolutionary relationship with ornithine aminotransferase. Gene. 1990;90:69-78 pubmed
    ..e., ornithine)-specific, S. cerevisiae ACOAT transaminates ornithine about as efficiently as E. coli does. The evolutionary relationship between ACOATs and OATs is discussed in terms of substrate ambiguity. ..
  42. Boyen A, Charlier D, Charlier J, Sakanyan V, Mett I, Glansdorff N. Acetylornithine deacetylase, succinyldiaminopimelate desuccinylase and carboxypeptidase G2 are evolutionarily related. Gene. 1992;116:1-6 pubmed
    ..G2 carboxypeptidase (G2CP); this or a functionally related enzyme may be responsible for the minor AO activity found in organisms relying on ornithine acetyltransferase for ornithine biosynthesis. ..