Experts and Doctors on apolipoprotein e4 in United States
Locale: United States
Topic: apolipoprotein e4
Schraml F, Chen K, Ayutyanont N, Auttawut R, Langbaum J, Lee W, et al
. Association between an Alzheimer's Disease-Related Index and APOE ?4 Gene Dose. PLoS ONE. 2013;8:e67163 pubmed publisher
..001). The HCI is associated with three levels of genetic risk for late-onset AD. This supports the possibility of using a single FDG PET measurement to help in the preclinical detection and tracking of AD. ..
Premkumar D, Cohen D, Hedera P, Friedland R, Kalaria R. Apolipoprotein E-epsilon4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology associated with Alzheimer's disease. Am J Pathol. 1996;148:2083-95 pubmed
..Our results suggest that the APOE-epsilon4 allele is a significant factor in the development of CAA in AD and reveal the possibility that APOE is an independent factor in CAA and other vascular abnormalities associated with AD. ..
Postupna N, Latimer C, Larson E, Sherfield E, Paladin J, Shively C, et al
. Human Striatal Dopaminergic and Regional Serotonergic Synaptic Degeneration with Lewy Body Disease and Inheritance of APOE Îµ4. Am J Pathol. 2017;187:884-895 pubmed publisher
Joutsa J, Rinne J, Hermann B, Karrasch M, Anttinen A, Shinnar S, et al
. Association Between Childhood-Onset Epilepsy and Amyloid Burden 5 Decades Later. JAMA Neurol. 2017;74:583-590 pubmed publisher
..Thus, epilepsy is linked with a biomarker that might be related to accelerated brain aging and can be considered a neurobiological predisposition to later-life cognitive disorders. ..
Relkin N, Thomas R, Rissman R, Brewer J, Rafii M, van Dyck C, et al
. A phase 3 trial of IV immunoglobulin for Alzheimer disease. Neurology. 2017;88:1768-1775 pubmed publisher
..NCT00818662. This study provides Class II evidence that IVIg infusions performed every 2 weeks do not improve cognition or function at 18 months in patients with mild to moderate AD. ..
Zhao J, Davis M, Martens Y, Shinohara M, Graff Radford N, Younkin S, et al
. APOE ?4/?4 diminishes neurotrophic function of human iPSC-derived astrocytes. Hum Mol Genet. 2017;26:2690-2700 pubmed publisher
Dong J, Pinto J, Guo X, Alonso A, TRANAH G, Cauley J, et al
. The Prevalence of Anosmia and Associated Factors Among U.S. Black and White Older Adults. J Gerontol A Biol Sci Med Sci. 2017;72:1080-1086 pubmed publisher
..Anosmia is common in older adults, particularly among blacks. Further studies are needed to identify risk factors for anosmia and to investigate racial disparities in this sensory deficit. ..
Ly H, Verma N, Wu F, Liu M, Saatman K, Nelson P, et al
. Brain microvascular injury and white matter disease provoked by diabetes-associated hyperamylinemia. Ann Neurol. 2017;82:208-222 pubmed publisher
..Ann Neurol 2017;82:208-222. ..
Zhao N, Liu C, Van Ingelgom A, Martens Y, Linares C, Knight J, et al
. Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes. Neuron. 2017;96:115-129.e5 pubmed publisher
..Together, our study provides novel mechanistic insights into the pathogenic mechanisms of apoE4 and insulin resistance in AD. ..