Experts and Doctors on antineoplastic agents in Taiwan

Summary

Locale: Taiwan
Topic: antineoplastic agents

Top Publications

  1. Shen S, Lin C, Lee H, Chien L, Chen Y. Lipopolysaccharide plus 12-o-tetradecanoylphorbol 13-acetate induction of migration and invasion of glioma cells in vitro and in vivo: Differential inhibitory effects of flavonoids. Neuroscience. 2006;140:477-89 pubmed
    ..Kaempferol and wogonin exhibit effective inhibitory effects on lipopolysaccharide/12-o-tetradecanoylphorbol 13-acetate-induced events, and thus possess the potential for further development. ..
  2. Lee W, Jin J, Tsai W, Chen Y, Chang W, Yao C, et al. Biological inhibitory effects of the Chinese herb danggui on brain astrocytoma. Pathobiology. 2006;73:141-8 pubmed
    ..Danggui may inhibit tumor growth by reducing the level of VEGF and the proapoptotic protein, cathepsin B. Thus, danggui may be useful in the treatment of high-grade astrocytomas. ..
  3. Liaw C, Shen Y, Lin Y, Hwang T, Kuo Y, Khalil A. Frajunolides E-K, briarane diterpenes from Junceella fragilis. J Nat Prod. 2008;71:1551-6 pubmed publisher
    ..The structures of 1-7 were determined by analysis of HRESIMS and 2D NMR spectroscopic data. Cytotoxicity and in vitro anti-inflammatory activities of compounds 1-7 were also evaluated. ..
  4. Lo Y, Ko T, Su W, Su T, Wang A. Terpyridine-platinum(II) complexes are effective inhibitors of mammalian topoisomerases and human thioredoxin reductase 1. J Inorg Biochem. 2009;103:1082-92 pubmed publisher
    ..Therefore, TP-Pt(II) complexes possess inhibitory activities against multiple biological targets, and they may be further studied as anticancer agents. ..
  5. Chiang C, Wang C, Chang H, More S, Li W, Hung W. A novel sialyltransferase inhibitor AL10 suppresses invasion and metastasis of lung cancer cells by inhibiting integrin-mediated signaling. J Cell Physiol. 2010;223:492-9 pubmed publisher
    ..Taken together, AL10 is the first ST inhibitor, which exhibits potent anti-metastatic activity in vivo and may be useful for clinical cancer treatment. ..
  6. Hsieh C, Liu C, Hsieh Y, Tai H, Wang L, Tsai T, et al. Matrix metalloproteinase-8 mediates the unfavorable systemic impact of local irradiation on pharmacokinetics of anti-cancer drug 5-Fluorouracil. PLoS ONE. 2011;6:e21000 pubmed publisher
    ..The pharmacokinetics of 5-FU during concurrent chemoradiaiton therapy should be rechecked and the optimal 5-FU dose should be reevaluated, and adjusted if necessary, during CCRT...
  7. Chung H, Hu L, Yen W, Su J, Lu M, Hwang T, et al. Echinohalimane A, a bioactive halimane-type diterpenoid from a Formosan gorgonian Echinomuricea sp. (Plexauridae). Mar Drugs. 2012;10:2246-53 pubmed publisher
    ..Echinohalimane A (1) is the first halimane analogue from the marine organisms belonging to phylum Cnidaria. ..
  8. Su J, Lin K, Chien C, Tseng C, Chen Y, Chang L, et al. Naphtho[1,2-b]furan-4,5-dione inactivates EGFR and PI3K/Akt signaling pathways in human lung adenocarcinoma A549 cells. Life Sci. 2010;86:207-13 pubmed publisher
    ..These findings indicate that EGFR and PI3K/Akt signaling pathways play important roles in NFD-induced apoptosis of A549 cells. ..
  9. Chen F, Liu Y, Yang C, Yang C. Anti-inflammatory effect of the proteasome inhibitor bortezomib on endotoxin-induced uveitis in rats. Invest Ophthalmol Vis Sci. 2012;53:3682-94 pubmed publisher
    ..Bortezomib inhibits EIU, probably by inhibiting the activation of NF-?B, which in turn, down-regulates the expression of the associated inflammatory genes. Proteasome inhibition may be a potential treatment strategy for uveitis. ..

More Information

Publications324 found, 100 shown here

  1. Hsieh W, Liang C, Chieh J, Wang S, Lai I, Chen J, et al. In vivo tumor targeting and imaging with anti-vascular endothelial growth factor antibody-conjugated dextran-coated iron oxide nanoparticles. Int J Nanomedicine. 2012;7:2833-42 pubmed publisher
  2. Chiang Y, Chang M, Chen P, Wu M, Hsieh C, Cheng W, et al. Epigenetic silencing of BLU through interfering apoptosis results in chemoresistance and poor prognosis of ovarian serous carcinoma patients. Endocr Relat Cancer. 2013;20:213-27 pubmed publisher
    ..Our study suggested that methylation of BLU could be a potential prognostic biomarker for advanced ovarian serous carcinoma. ..
  3. Hsieh C, Tsai P, Chu C, Chang F, Chang L, Wu Y, et al. Brazilein suppresses migration and invasion of MDA-MB-231 breast cancer cells. Chem Biol Interact. 2013;204:105-15 pubmed publisher
    ..Consequently, brazilein suppresses MMP-2 expression, and thus confers anti-migration and anti-invasion of MDA-MB-231 cells. ..
  4. Wu C, Li Y, Wang Y, Li T, Chan N. On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs. Nucleic Acids Res. 2013;41:10630-40 pubmed publisher
    ..Drug design guidelines were proposed to facilitate the development of isoform-specific Top2-targeting anticancer agents. ..
  5. Hung M, Chen K. Reprogramming the oncogenic response: SET protein as a potential therapeutic target in cancer. Expert Opin Ther Targets. 2017;21:685-694 pubmed publisher
    ..However, more studies are required to clarify the best strategy to combine SET antagonists with other anti-cancer treatments and to explore possible biomarkers that predict responsiveness. ..
  6. Liu Y, Leu C, Wong F, Fong W, Chen S, Chang C, et al. Autocrine stimulation by insulin-like growth factor I is involved in the growth, tumorigenicity and chemoresistance of human esophageal carcinoma cells. J Biomed Sci. 2002;9:665-74 pubmed
    ..Thus, interruption of IGF-IR function may provide a way to retard tumor growth and increase the sensitivity of esophageal carcinoma to chemotherapy. ..
  7. Duh C, El Gamal A, Chu C, Wang S, Dai C. New cytotoxic constituents from the Formosan soft corals Clavularia viridis and Clavularia violacea. J Nat Prod. 2002;65:1535-9 pubmed
    ..The structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro. ..
  8. Lee T, Chen H, Yeh M. Effects of chan-chuang qigong on improving symptom and psychological distress in chemotherapy patients. Am J Chin Med. 2006;34:37-46 pubmed
    ..05) were significantly improved in the experimental group. In conclusion, Chan-Chuang qigong had the effect of attenuating the symptom distress and probably some part of the psychological distress of chemotherapy patients. ..
  9. Huang H, Chiu H, Tao C, Chen I. Synthesis and antitumor evaluation of symmetrical 1,5-diamidoanthraquinone derivatives as compared to their disubstituted homologues. Chem Pharm Bull (Tokyo). 2006;54:458-64 pubmed
    ..We further delineate the nature of the pharmacophore for this class of compounds, which provides a rational basis for the structure-activity relationships. ..
  10. Kau H, Tsai C. Abducens ocular neuromyotonia in a patient with nasopharyngeal carcinoma following concurrent chemoradiotherapy. J Neuroophthalmol. 2010;30:266-7 pubmed publisher
    ..While diplopic complaints in patients with NPC raise suspicion of tumor recurrence or radiation-related cranial neuropathy, ONM must also be kept in the differential diagnosis. ..
  11. Chang W, Liu T, Yang W, Lee C, Lin Y, Chen T, et al. Amiloride modulates alternative splicing in leukemic cells and resensitizes Bcr-AblT315I mutant cells to imatinib. Cancer Res. 2011;71:383-92 pubmed publisher
    ..Our findings suggest that amiloride may offer a potential treatment option for chronic myelogenous leukemia either alone or in combination with imatinib. ..
  12. Wu J, Chien C, Yang L, Huang G, Cheng M, Lin C, et al. Vitamin K3-2,3-epoxide induction of apoptosis with activation of ROS-dependent ERK and JNK protein phosphorylation in human glioma cells. Chem Biol Interact. 2011;193:3-11 pubmed publisher
    ..Our findings demonstrate that 2,3-epoxide substitution significantly potentiates the apoptotic effect of vitamin K3 via stimulating ROS production, which may be useful in the chemotherapy of glioblastoma cells. ..
  13. Chien M, Lee T, Kao C, Yang S, Lee W. Terbinafine inhibits oral squamous cell carcinoma growth through anti-cancer cell proliferation and anti-angiogenesis. Mol Carcinog. 2012;51:389-99 pubmed publisher
    ..These findings demonstrate for the first time that TB might have potential to serve as a therapeutic tool in the treatment of oral cancer. ..
  14. Pei S, Ma M, Wang M, Kuo C, Rau K, Su C, et al. Analysis of hepatitis B surface antibody titers in B cell lymphoma patients after rituximab therapy. Ann Hematol. 2012;91:1007-12 pubmed publisher
    ..001) after rituximab treatment. B cell lymphoma patients with low pre-treatment anti-HBs titers (<100 mIU/mL) were more likely to lose anti-HBs antibodies and were at risk of HBV reactivation after rituximab immunochemotherapy. ..
  15. Chang C, Hsiao C, Yeh Y, Chang G, Tsai Y, Chen Y, et al. Circulating interleukin-6 level is a prognostic marker for survival in advanced nonsmall cell lung cancer patients treated with chemotherapy. Int J Cancer. 2013;132:1977-85 pubmed publisher
    ..Patients with high circulating IL-6 also responded poorly to chemotherapy. Therefore, a high level of circulating IL-6 was associated with an inferior response and survival outcome in NSCLC patients treated with chemotherapy. ..
  16. Sung P, Jan Y, Lin S, Huang C, Lin H, Wen K, et al. Periostin in tumor microenvironment is associated with poor prognosis and platinum resistance in epithelial ovarian carcinoma. Oncotarget. 2016;7:4036-47 pubmed publisher
    ..The effect of POSTN in cancer stroma cells may activate AKT pathway in tumor and AKT inhibitor can be beneficial to augment the efficacy of existing cancer therapeutics. ..
  17. Hour T, Chen J, Huang C, Guan J, Lu S, Pu Y. Curcumin enhances cytotoxicity of chemotherapeutic agents in prostate cancer cells by inducing p21(WAF1/CIP1) and C/EBPbeta expressions and suppressing NF-kappaB activation. Prostate. 2002;51:211-8 pubmed
    ..Moreover, CCM was able to inhibit both the constitutional and TNF-alpha-induced NF-kappaB activation in a time-dependent manner. The incorporation of CCM into cytotoxic therapies may be a promising strategy for the treatment of AIPC. ..
  18. Yang L, Chang C, Chen L, Wang C. Antitumor principle constituents of Myrica rubra Var. acuminata. J Agric Food Chem. 2003;51:2974-9 pubmed
    ..Therefore, we suggest that the 20% MeOH eluate fraction extract is good for health and that M. rubra var. acuminata is an economically valuable plant. ..
  19. Duh C, Li C, Wang S, Dai C. Diterpenoids, norditerpenoids, and secosteroids from the Formosan soft coral Cespitularia hypotentaculata. J Nat Prod. 2006;69:1188-92 pubmed
    ..The structures were elucidated by extensive spectroscopic analysis, and their cytotoxicity against selected cancer cells was measured in vitro. ..
  20. Wang S, Duh C. Nardosinane sesquiterpenoids from the formosan soft coral Nephthea elongata. Chem Pharm Bull (Tokyo). 2007;55:762-5 pubmed
    ..Their structures were elucidated by extensive spectroscopic analysis and their cytotoxicity against selected cancer cells was measured in vitro. ..
  21. Su R, Chao Y, Chen T, Huang D, Lin W. 5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling. Mol Cancer Ther. 2007;6:1562-71 pubmed
    ..The sensitization effect of AICAR in cell apoptosis was mediated through AMPK pathway, requires p53 activity, and involves mitochondria-dependent apoptotic cascades, p38 and c-Jun NH(2)-terminal kinase. ..
  22. Wang S, Pan S, Huang Y, Guh J, Chiang P, Huang D, et al. CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo. Mol Cancer Ther. 2008;7:350-60 pubmed publisher
    ..CHM-1 is a promising chemotherapeutic agent worthy of further development into a clinical trial candidate for treating cancer, especially hepatocellular carcinoma. ..
  23. Hsu C, Shen Y, Cheng C, Cheng A, Hu F, Yeh K. Geographic difference in safety and efficacy of systemicchemotherapy for advanced gastric or gastroesophagealcarcinoma: a meta-analysis and meta-regression. Gastric Cancer. 2012;15:265-80 pubmed publisher
    ..Geographic region (Asian vs. non-Asian) is an independent predictor of safety in systemic therapy for gastric cancer. ..
  24. Shen K, Hung J, Chang C, Weng Y, Wu M, Chen P. Solasodine inhibits invasion of human lung cancer cell through downregulation of miR-21 and MMPs expression. Chem Biol Interact. 2017;268:129-135 pubmed publisher
    ..Solasodine also reduces PI3K/Akt signaling pathways and downregulates expression of miR-21. These findings demonstrate an attractive therapeutic potential for solasodine in lung cancer anti-metastatic therapy. ..
  25. Liu J, Huang T, Hsu M, Chen C, Lin W, Lu F, et al. Antitumor effects of the partially purified polysaccharides from Antrodia camphorata and the mechanism of its action. Toxicol Appl Pharmacol. 2004;201:186-93 pubmed
    ..Besides, the mice serum interleukin-12 levels increased significantly by AC-PS treatment. Considering all these results, it is suggested that AC-PS elicit its anti-tumor effect by promoting a Th1-dominant state and killer activities...
  26. Lu Y, Yeh P, Chuang S, Gao M, Kuo M, Cheng A. Glucocorticoids enhance cytotoxicity of cisplatin via suppression of NF-{kappa}B activation in the glucocorticoid receptor-rich human cervical carcinoma cell line SiHa. J Endocrinol. 2006;188:311-9 pubmed
    ..Our data suggest that the specific action of DEX on GR may enhance the cytotoxicity of cisplatin in selected GR-rich cancer cells by suppressing NF-kappaB activation. ..
  27. Yang Y, Hsu Y, Wu C, Chen H, Chang M. Silencing of astrin induces the p53-dependent apoptosis by suppression of HPV18 E6 expression and sensitizes cells to paclitaxel treatment in HeLa cells. Biochem Biophys Res Commun. 2006;343:428-34 pubmed
    ..These findings suggest that the silencing of astrin induce a p53-dependent apoptosis and has an additive effect on paclitaxel treatment. ..
  28. Lin C, Hsu C, Huang C, Tsai Y, Huang K, Cheng A, et al. Prognostic factors for metastatic urothelial carcinoma treated with cisplatin and 5-fluorouracil-based regimens. Urology. 2007;69:479-84 pubmed
  29. Chang H, Wu Y, Su J, Yeh Y, Yuan S. Protoapigenone, a novel flavonoid, induces apoptosis in human prostate cancer cells through activation of p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase 1/2. J Pharmacol Exp Ther. 2008;325:841-9 pubmed publisher
    ..In conclusion, our results demonstrated protoapigenone suppressed prostate cancer cell growth through the activation of p38 MAPK and JNK1/2, with the potential to be developed as a chemotherapeutic agent for prostate cancer. ..
  30. Yang C, Wang C, Hung J, Huang H, Chia Y, Wang P, et al. Pyrogallol induces G2-M arrest in human lung cancer cells and inhibits tumor growth in an animal model. Lung Cancer. 2009;66:162-8 pubmed publisher
    ..Taken in vitro and in vivo studies together, these results suggest that pyrogallol can be developed as a promising anti-lung cancer drug particular for the non-small cell lung cancer (NSCLC). ..
  31. Chi C, Wang Y, Yang C, Chi K. Neoadjuvant immunotherapy enhances radiosensitivity through natural killer cell activation. Cancer Biother Radiopharm. 2010;25:39-45 pubmed publisher
    ..Neoadjuvant immunotherapy with CpG/Herceptin may improve response to radiotherapy of HER2/neu-expressing tumors. ..
  32. Chen Y, Kay N, Yang J, Lin C, Chang H, Wu Y, et al. Total synthetic protoapigenone WYC02 inhibits cervical cancer cell proliferation and tumour growth through PIK3 signalling pathway. Basic Clin Pharmacol Toxicol. 2013;113:8-18 pubmed publisher
    ..WYC02 inhibits cervical cancer cell proliferation and tumourigenesis via PIK3 signalling pathway and has the potential to be developed as a chemotherapeutic agent in cervical cancer. ..
  33. Lin J, Fang S, Su C, Hsiao C, Chang C, Lin Y, et al. Silencing glucose-regulated protein 78 induced renal cell carcinoma cell line G1 cell-cycle arrest and resistance to conventional chemotherapy. Urol Oncol. 2014;32:29.e1-11 pubmed publisher
    ..Overall, our findings indicate the regulatory function of Grp78 in RCC cell proliferation, and provide a molecular-based mechanism of Grp78 positivity in the progression of RCC. ..
  34. Kao H, Lin Y, Chen C, Chi K, Tien D, Hsia C, et al. Evaluation of EGFR-targeted radioimmuno-gold-nanoparticles as a theranostic agent in a tumor animal model. Bioorg Med Chem Lett. 2013;23:3180-5 pubmed publisher
  35. Chen I, Lin C, Jan I, Cheng A, Lu Y. Bevacizumab might potentiate the chemotherapeutic effect in breast cancer patients with leptomeningeal carcinomatosis. J Formos Med Assoc. 2016;115:243-8 pubmed publisher
    ..Their overall survival after development of LC was 8 months and 7.5 months respectively. Bevacizumab plus etoposide and cisplatin might be a new option for breast cancer patients with LC. Further prospective study is warranted. ..
  36. Chen Y, Hung M, Chu P, Chao T, Tsai M, Chen L, et al. Protein phosphatase 5 promotes hepatocarcinogenesis through interaction with AMP-activated protein kinase. Biochem Pharmacol. 2017;138:49-60 pubmed publisher
    ..Overall, our results establish a pathological function of PP5 in hepatocarcinogenesis via affecting AMPK signaling and suggest that PP5 inhibition is an attractive therapeutic approach for HCC. ..
  37. Chiang C, Chao T, Su Y, Hsu C, Chien C, Chiu K, et al. Metformin-treated cancer cells modulate macrophage polarization through AMPK-NF-?B signaling. Oncotarget. 2017;8:20706-20718 pubmed publisher
    ..These findings suggest that metformin activates cancer AMPK-NF-?B signaling, a pathway involved in regulating M1/M2 expression and inducing genes for macrophage polarization to anti-tumor phenotype. ..
  38. Wu C, Chan M, Chen W, Tsai C, Chang F, Wu Y. Pristimerin induces caspase-dependent apoptosis in MDA-MB-231 cells via direct effects on mitochondria. Mol Cancer Ther. 2005;4:1277-85 pubmed
    ..Taken together, these results suggested that pristimerin is a novel mitochondria-targeted compound and may be further evaluated as a chemotherapeutic agent for human cancer. ..
  39. Su H, Lai H, Lin Y, Liu C, Chen C, Chou Y, et al. Epigenetic silencing of SFRP5 is related to malignant phenotype and chemoresistance of ovarian cancer through Wnt signaling pathway. Int J Cancer. 2010;127:555-67 pubmed publisher
    ..Our data suggested that epigenetic silencing of SFRP5 leads to oncogenic activation of the Wnt pathway and contributes to ovarian cancer progression and chemoresistance through the TWIST-mediated EMT and AKT2 signaling. ..
  40. Lai C, Li S, Miyauchi Y, Suzawa M, Ho C, Pan M. Potent anti-cancer effects of citrus peel flavonoids in human prostate xenograft tumors. Food Funct. 2013;4:944-9 pubmed publisher
    ..Our findings suggest that GL is an effective anti-cancer agent that may potentially serve as a novel therapeutic option for prostate cancer treatment...
  41. Kuo C, Liu T, Chan T, Tsai S, Hardiansyah A, Huang L, et al. Magnetically triggered nanovehicles for controlled drug release as a colorectal cancer therapy. Colloids Surf B Biointerfaces. 2016;140:567-573 pubmed publisher
    ..The combination of remote control, targeted dosing, drug-loading flexibility, and thermotherapy and chemotherapy suggests that magnetic nanovehicles such as MPVA-AP1 have great potential for application in cancer therapy. ..
  42. Cheng T, Wu P, Wu M, Chern J, Roffler S. Accelerated clearance of polyethylene glycol-modified proteins by anti-polyethylene glycol IgM. Bioconjug Chem. 1999;10:520-8 pubmed
    ..AGP3 should be generally useful for accelerating the clearance of PEG-modified proteins as well as for improving the tumor/blood ratios of antibody-betaG-PEG conjugates for glucuronide prodrug therapy of cancer. ..
  43. Chen K, Peng C, Peng R, Su C, Chiang H, Yan J, et al. Unique formosan mushroom Antrodia camphorata differentially inhibits androgen-responsive LNCaP and -independent PC-3 prostate cancer cells. Nutr Cancer. 2007;57:111-21 pubmed
  44. Tan S, Juan Y, Fu P, Yu M, Lai H. Chemotherapy with low-dose bevacizumab and carboplatin in the treatment of a patient with recurrent cervical cancer. Eur J Gynaecol Oncol. 2010;31:350-3 pubmed
    ..We present the case of a patient with platinum-resistant recurrent cervical cancer treated with low-dose bevacizumab and carboplatin, with resultant improved disease progression and tolerable toxicity profiles. ..
  45. Wu S, Gow C, Yu C, Chang Y, Yang C, Hsu Y, et al. Frequent epidermal growth factor receptor gene mutations in malignant pleural effusion of lung adenocarcinoma. Eur Respir J. 2008;32:924-30 pubmed publisher
    ..Epidermal growth factor receptor tyrosine kinase inhibitors may be the treatment of choice for lung adenocarcinoma with malignant pleural effusions in east Asia. ..
  46. Chung L, Tsui K, Feng T, Lee S, Chang P, Juang H. Curcumin provides potential protection against the activation of hypoxia and prolyl 4-hydroxylase inhibitors on prostate-specific antigen expression in human prostate carcinoma cells. Mol Nutr Food Res. 2011;55:1666-76 pubmed publisher
    ..These results indicate that curcumin blocked the enhanced effect of PSA expression by L-mimosine and DMOG that induce hypoxia condition. ..
  47. Huang M, Lim K, Tzen C, Hsu H, Yen Y, Huang B. EGFR mutations in malignant pleural effusion of non-small cell lung cancer: a case report. Lung Cancer. 2005;49:413-5 pubmed
    ..This case demonstrated the importance of molecular cytology in the era of targeted therapy. ..
  48. Paz Ares L, Hirsh V, Zhang L, De Marinis F, Yang J, Wakelee H, et al. Monotherapy Administration of Sorafenib in Patients With Non-Small Cell Lung Cancer (MISSION) Trial: A Phase III, Multicenter, Placebo-Controlled Trial of Sorafenib in Patients with Relapsed or Refractory Predominantly Nonsquamous Non-Small-Cell Lung. J Thorac Oncol. 2015;10:1745-53 pubmed publisher
    ..Third-/fourth-line sorafenib therapy did not significantly increase OS in patients with relapsed/refractory NSCLC, despite significantly increasing PFS. ..
  49. El Gamal A, Chiu E, Li C, Cheng S, Dai C, Duh C. Sesquiterpenoids and norsesquiterpenoids from the Formosan soft coral Lemnalia laevis. J Nat Prod. 2005;68:1749-53 pubmed
    ..Their structures were elucidated by extensive spectroscopic analysis, and their cytotoxicity against selected cancer cells was measured in vitro. ..
  50. Wang S, Duh C. New cytotoxic cembranolides from the soft coral Lobophytum michaelae. Mar Drugs. 2012;10:306-18 pubmed publisher
    ..Their structures were established by extensive spectral analysis. The anti-HCMV (human cytomegalovirus) activity of 1-7 and their cytotoxicity against selected cell lines were evaluated. ..
  51. Tsai M, Kuo C, Wang M, Wu H, Chien C, Liu J. Clinical features and risk factors for mortality in Aeromonas bacteremic adults with hematologic malignancies. J Microbiol Immunol Infect. 2006;39:150-4 pubmed
    ..In febrile patients with hematologic malignancies and suspected Aeromonas infections, particular attention to the development of alteration of consciousness is needed as it is an independent risk factor for mortality. ..
  52. Yang C. EGFR tyrosine kinase inhibitors for the treatment of NSCLC in East Asia: present and future. Lung Cancer. 2008;60 Suppl 2:S23-30 pubmed publisher
    ..In addition, the presence of EGFR mutations is a useful tool to determine NSCLC patients' prognosis; some studies suggested that this may apply if patients are receiving first-line chemotherapy, not only if they are receiving EGFR-TKIs. ..
  53. Hsu H, Chen M, Day C, Lin Y, Li S, Tu C, et al. Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation. World J Gastroenterol. 2017;23:1171-1179 pubmed publisher
    ..TQ inhibits LoVo cancer cell growth and migration, and this result highlights the therapeutic advantage of using TQ in combination therapy against colorectal cancer. ..
  54. Chen W, Chen C, Chen H, Hung Y, Chu J. Mucinous cystadenocarcinoma of the breast coexisting with infiltrating ductal carcinoma. Pathol Int. 2004;54:781-6 pubmed
    ..According to the previously reported and present cases, MCA of the breast more commonly affects elderly women and has a relatively favorable prognosis...
  55. Chiang C, Way T, Tsai S, Lin J. Diosgenin, a naturally occurring steroid, suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt, mTOR and JNK phosphorylation. FEBS Lett. 2007;581:5735-42 pubmed
    ..These results suggested that diosgenin has the potential to advance as chemopreventive or chemotherapeutic agent for cancers that overexpress HER2. ..
  56. Cheng S, Wang S, Chiou S, Hsu C, Dai C, Chiang M, et al. Cembranoids from the octocoral Sarcophyton ehrenbergi. J Nat Prod. 2010;73:197-203 pubmed publisher
    ..Moreover, metabolites 1-6 were evaluated in vitro for their cytotoxicity against selected cancer and normal cells lines, antiviral activity against human cytomegalovirus, and antibacterial activity against Salmonella enteritidis...
  57. Huang H, Hu S, Hung S, Chiang C, Liu H, Chiu T, et al. SPIO nanoparticle-stabilized PAA-F127 thermosensitive nanobubbles with MR/US dual-modality imaging and HIFU-triggered drug release for magnetically guided in vivo tumor therapy. J Control Release. 2013;172:118-127 pubmed publisher
    ..The integration of functionalities makes this nanobubble system a powerful and viable new tool to achieve simultaneous in vivo tumor imaging and efficacious cancer therapy. ..
  58. Ahmed A, Wu M, Wang G, Wu Y, Sheu J. Eunicellin-based diterpenoids, australins A-D, isolated from the soft coral Cladiella australis. J Nat Prod. 2005;68:1051-5 pubmed
    ..Metabolite 2 was found to possess a moderate cytotoxic activity against selected breast and liver cancer cell lines. ..
  59. Lencioni R, Llovet J, Han G, Tak W, Yang J, Guglielmi A, et al. Sorafenib or placebo plus TACE with doxorubicin-eluting beads for intermediate stage HCC: The SPACE trial. J Hepatol. 2016;64:1090-1098 pubmed publisher
    ..224 days). No unexpected adverse events related to sorafenib were observed. Sorafenib plus DEB-TACE was technically feasible, but the combination did not improve TTP in a clinically meaningful manner compared with DEB-TACE alone. ..
  60. Shao Y, Lin C, Yang C. Gefitinib or erlotinib in the treatment of advanced non-small cell lung cancer. Discov Med. 2010;9:538-45 pubmed
    ..The adequate-powered, direct comparisons of gefitinib against erlotinib under the same clinical scenarios are lacking. There is no evidence at present that the efficacy of these two agents in NSCLC is different. ..
  61. Liu Y, Wang W. Human mu-opioid receptor gene A118G polymorphism predicts the efficacy of tramadol/acetaminophen combination tablets (ultracet) in oxaliplatin-induced painful neuropathy. Cancer. 2012;118:1718-25 pubmed publisher
    ..A118G polymorphism of OPRM1, by altered function of the mu-opioid receptor and consequential analgesic effect on opioid agents, could be a key determinant for decreased response to Ultracet. ..
  62. Shen C, Chang C, Chen Y, Lai C, Hsu Y. Melatonin Suppresses the Growth of Ovarian Cancer Cell Lines (OVCAR-429 and PA-1) and Potentiates the Effect of G1 Arrest by Targeting CDKs. Int J Mol Sci. 2016;17: pubmed publisher
    ..Our results suggest that in addition to the known effects on prevention, melatonin may also provide anti-tumor activity in established ovarian cancer. ..
  63. Ho C, Jie Pinge O, Liu Y, Hung C, Tsai M, Liao P, et al. Compositions and in vitro anticancer activities of the leaf and fruit oils of Litsea cubeba from Taiwan. Nat Prod Commun. 2010;5:617-20 pubmed
    ..The main compound in the leaf oil was 1,8-cineol, and in the fruit oil, citral. The fruit oil, but not that of the leaf, exhibited cytotoxic activity against human lung, liver and oral cancer cells...
  64. Lin Y, Huang L, Lin C, Huang P, Chen Y, Wong F, et al. In vitro and in vivo anticancer activity of a synthetic glycolipid as Toll-like receptor 4 (TLR4) activator. J Biol Chem. 2011;286:43782-92 pubmed publisher
    ..Altogether, this study reveals the anticancer activity of a new synthetic TLR4 agonist and broadens the molecular basis of TLR4-activating glycolipids. ..
  65. Hsu L, Hsu Y, Liang Y, Liaw C, Kuo Y, Pan T. Induction of apoptosis in human breast adenocarcinoma cells MCF-7 by monapurpyridine A, a new azaphilone derivative from Monascus purpureus NTU 568. Molecules. 2012;17:664-73 pubmed publisher
    ..All evidence supported that MPA was suitable for developing into a chemotherapeutic or chemopreventive agent against breast cancer. ..
  66. Tseng L, Liu C, Chang K, Chu P, Shiau C, Chen K. CIP2A is a target of bortezomib in human triple negative breast cancer cells. Breast Cancer Res. 2012;14:R68 pubmed
    ..Importantly, CIP2A expression is readily detectable in tumor samples from TNBC patients. CIP2A is a major determinant mediating bortezomib-induced apoptosis in TNBC cells. CIP2A may thus be a potential therapeutic target in TNBC. ..
  67. Hsieh C, Kuo Y, Liao L, Hu K, Lin S, Wu L, et al. Image-guided intensity modulated radiotherapy with helical tomotherapy for postoperative treatment of high-risk oral cavity cancer. BMC Cancer. 2011;11:37 pubmed publisher
    ..HT achieved encouraging clinical outcomes for postoperative high-risk oral cavity cancer patients with high compliance. A long-term follow-up study is needed to confirm these preliminary findings. ..
  68. Tu L, Chen C, Hsiao I, Chern J, Lin C, Shen Y, et al. The beta-carboline analog Mana-Hox causes mitotic aberration by interacting with DNA. Chem Biol. 2005;12:1317-24 pubmed
    ..Overall, Mana-Hox binding to DNA plays a critical role in the induction of aberrant mitosis and contributes to its anticancer activity. ..
  69. Yang L, Wang M, Chen L, Wang C. Cytotoxic activity of coumarins from the fruits of Cnidium monnieri on leukemia cell lines. Planta Med. 2003;69:1091-5 pubmed
    ..These results indicate that osthol and imperatorin can induce apoptosis in HL-60 cells. Therefore, osthol and imperatorin are cytotoxic marker substances in the fruits of Cnidium monnieri. ..
  70. Lee C, Hsieh M, Hsin L, Chen H, Lo S, Fan J, et al. Anthracenedione-methionine conjugates are novel topoisomerase II-targeting anticancer agents with favorable drug resistance profiles. Biochem Pharmacol. 2012;83:1208-16 pubmed publisher
    ..Furthermore, Met-MACs are poor substrates for the MDR1 transporter. Therefore, L/LMet-MAC represents a promising class of TOP2-targeting drugs with favorable drug resistance profiles. ..
  71. Lin S, Chueh S, Hsiao C, Li T, Chen T, Liao C, et al. Prazosin displays anticancer activity against human prostate cancers: targeting DNA and cell cycle. Neoplasia. 2007;9:830-9 pubmed
    ..Subsequently, mitochondria-mediated caspase cascades are triggered to induce apoptosis in PC-3 cells. ..
  72. Pan M, Chang H, Hung W. Non-steroidal anti-inflammatory drugs suppress the ERK signaling pathway via block of Ras/c-Raf interaction and activation of MAP kinase phosphatases. Cell Signal. 2008;20:1134-41 pubmed publisher
    ..Taken together, we conclude that NS398 and other NSAIDs act via inhibition of Ras/c-Raf interaction and up-regulation of MKPs to suppress the ERK-mediated signaling. ..
  73. Yeh C, Rao Y, Ye M, Wu W, Chang T, Wang L, et al. Preclinical evaluation of destruxin B as a novel Wnt signaling target suppressing proliferation and metastasis of colorectal cancer using non-invasive bioluminescence imaging. Toxicol Appl Pharmacol. 2012;261:31-41 pubmed publisher
    ..Collectively, our data supports DB as an inhibitor of Wnt/?-catenin/Tcf signaling pathway that may be beneficial in the CRC management. ..
  74. Huang C, Tsai M, Chang T, Tang W, Chen S, Lai H, et al. ALDH-positive lung cancer stem cells confer resistance to epidermal growth factor receptor tyrosine kinase inhibitors. Cancer Lett. 2013;328:144-51 pubmed publisher
    ..These findings collectively suggest that ALDH1A1 positivity in cancer stem cells confers resistance to EGFR TKI in lung cancer. ..
  75. Brose M, Smit J, Lin C, Pitoia F, Fellous M, Desanctis Y, et al. Timing of multikinase inhibitor initiation in differentiated thyroid cancer. Endocr Relat Cancer. 2017;24:237-242 pubmed publisher
    ..In total, 700 patients are estimated to be enrolled from >20 countries. Final analysis will be performed once the last enrolled patient has been followed up with for 24 months (ClinicalTrials.gov identifier: Nbib2303444). ..
  76. Shen Y, Cheng S, Kuo Y, Hwang T, Chiang M, Khalil A. Chemical transformation and biological activities of ambrein, a major product of ambergris from Physeter macrocephalus (sperm whale). J Nat Prod. 2007;70:147-53 pubmed
    ..The anti-inflammatory activities of 1-11, in terms of the inhibition of human neutrophil function, were also evaluated. ..
  77. Chiu C, Shih Y, Tsai C, Liou J, Chen Y, Perng R. Serum tumor markers as predictors for survival in advanced non-small cell lung cancer patients treated with gefitinib. Lung Cancer. 2007;57:213-21 pubmed
    ..In gefitinib-treated NSCLC patients, correlation was good between 4-week TMR and IBR. Four-week TMR was predictive for survival. TMR may serve as a tool for assessing the gefitinib response in patients without measurable lesions. ..
  78. Liu W, Chen Y, Chang L. CIL-102 induces matrix metalloproteinase-2 (MMP-2)/MMP-9 down-regulation via simultaneous suppression of genetic transcription and mRNA stability. Int J Biochem Cell Biol. 2012;44:2212-22 pubmed publisher
  79. Chiang L, Ng L, Lin I, Kuo P, Lin C. Anti-proliferative effect of apigenin and its apoptotic induction in human Hep G2 cells. Cancer Lett. 2006;237:207-14 pubmed
    ..The present study concludes that the anti-hepatoma activity of apigenin is as effective as 5-FU and its apoptotic mechanism might be mediated through the p53-dependent pathway and the induction of p21 expression. ..
  80. Wang S, Dai C, Duh C. Cytotoxic pregnane steroids from the formosan soft coral Stereonephthya crystalliana. J Nat Prod. 2006;69:103-6 pubmed
    ..The structures were elucidated by extensive spectroscopic analysis, and their cytotoxicity against selected cancer cells was measured in vitro. ..
  81. Chen H, Chang F, Hsieh Y, Cheng Y, Hsieh K, Tsai L, et al. A novel synthetic protoapigenone analogue, WYC02-9, induces DNA damage and apoptosis in DU145 prostate cancer cells through generation of reactive oxygen species. Free Radic Biol Med. 2011;50:1151-62 pubmed publisher
    ..These findings therefore suggest that WYC02-9-induced DNA damage and mitochondria-dependent cell apoptosis in DU145 cells are mediated via ROS generation. ..
  82. Chen C, Hsiao C, Lee S, Guh J, Chiang P, Huang C, et al. Chemical modification and anticancer effect of prenylated flavanones from Taiwanese propolis. Nat Prod Res. 2012;26:116-24 pubmed publisher
    ..This suggests that prenylated flavanones 10c, 11 and 12 may have anticancer potential for further development. ..
  83. Yang C, Hsieh C, Lin C, Lin C, Peng B, Lin G, et al. Danshen extract circumvents drug resistance and represses cell growth in human oral cancer cells. BMC Complement Altern Med. 2017;17:555 pubmed publisher
    ..Furthermore, the Danshen extract circumvented drug resistance in KB drug-resistant oral cancer cells. The study results suggest that the Danshen extract could be a potential anticancer agent in oral cancer treatment. ..
  84. Lee S, Chu P. Toxic epidermal necrolysis caused by cetuximab plus minocycline in head and neck cancer. Am J Otolaryngol. 2010;31:288-90 pubmed publisher
    ..We review the literature on cetuximab, minocycline, and TEN and discuss the impact of TEN on cancer therapy. ..
  85. Nien C, Chen Y, Kuo C, Hsieh H, Chang C, Wu J, et al. 5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors. J Med Chem. 2010;53:2309-13 pubmed publisher
    ..Compound 15 (IC(50) = 1.6 microM) exhibited more potent inhibition of tubulin polymerization than 1a (IC(50) = 2.1 microM) and showed strong binding property to the colchicine binding site of microtubules. ..
  86. Lin Y, Chen S, Liu C, Nieh S. The chemoadjuvant potential of grape seed procyanidins on p53-related cell death in oral cancer cells. J Oral Pathol Med. 2012;41:322-31 pubmed publisher
    ..GSP displays chemoadjuvant potential via cell cycle blockage and apoptotic induction. Our findings clearly suggest that GSP may play a role as a novel chemopreventive or therapeutic agent for OSCC. ..
  87. Liu C, Shiau C, Kuo H, Huang H, Chen M, Tzeng C, et al. Cancerous inhibitor of protein phosphatase 2A determines bortezomib-induced apoptosis in leukemia cells. Haematologica. 2013;98:729-38 pubmed publisher
    ..Cancerous inhibitor of protein phosphatase 2A was expressed in leukemic blasts from bone marrow samples. Cancerous inhibitor of protein phosphatase 2A plays a major role in mediating bortezomib-induced apoptosis in leukemia cells. ..
  88. Tzeng C, Tzeng W, Lin L, Lee C, Yen F, Lin C. Enhanced autophagic activity of artocarpin in human hepatocellular carcinoma cells through improving its solubility by a nanoparticle system. Phytomedicine. 2016;23:528-40 pubmed publisher
    ..The research provided a basis of ArtN could be explored as a low-dose alternative of artocarpin in anticancer treatment and research applications. ..
  89. Lee H, Tsan Y, Ho W, Lin M, Lee C, Tseng C, et al. Angiotensin-converting enzyme inhibitors enhance the effect of cyclooxygenase inhibitors on breast cancer: a nationwide case-control study. J Hypertens. 2012;30:2432-9 pubmed publisher
    ..70), and 0.60 (0.52-0.70) as the ACE inhibitor dose increased, respectively. The findings of this nationwide analysis support the hypothesis that ACE inhibitors enhance the antitumor effect of cyclooxygenase inhibitors on breast cancer. ..
  90. Han Y, Cui Z, Li Y, Hsu W, Lee B. In Vitro and in Vivo Anticancer Activity of Pardaxin against Proliferation and Growth of Oral Squamous Cell Carcinoma. Mar Drugs. 2015;14:2 pubmed publisher
    ..These results suggest that pardaxin is a potential marine drug for adjuvant chemotherapy for human OSCC and oral cancer. ..
  91. Hsieh H, Chuang H, Shen F, Detroja K, Hsin L, Chen C. Targeting breast cancer stem cells by novel HDAC3-selective inhibitors. Eur J Med Chem. 2017;140:42-51 pubmed publisher
    ..Equally important, they showed in vitro and/or in vivo efficacy in suppressing the CSC subpopulation of TNBC cells via the downregulation of ?-catenin. ..
  92. Kuo P, Hsu Y, Ng L, Lin C. Rhein inhibits the growth and induces the apoptosis of Hep G2 cells. Planta Med. 2004;70:12-6 pubmed
    ..Taken together, p53 and the CD95/CD95L apoptotic system possibly participated in the antiproliferative activity of rhein in Hep G2 cells...