Genomes and Genes
Experts and Doctors on anticonvulsants in United States
Locale: United States
Publications180 found, 100 shown here
- El Mallakh R, Elmaadawi A, Loganathan M, Lohano K, Gao Y. Bipolar disorder: an update. Postgrad Med. 2010;122:24-31 pubmed publisher..The use of multiple agents appears to be superior to monotherapy in relapse prevention. Despite the many advances in the pharmacotherapy of bipolar disorder, the overall prognosis of this severe illness does not appear to have changed. ..
- Lamson M, Sitki Green D, Wannarka G, Mesa M, Andrews P, PELLOCK J. Pharmacokinetics of diazepam administered intramuscularly by autoinjector versus rectal gel in healthy subjects: a phase I, randomized, open-label, single-dose, crossover, single-centre study. Clin Drug Investig. 2011;31:585-597 pubmed publisher..Results of the present study indicated that diazepam can be safely and reliably administered IM using a diazepam autoinjector. ..
- Spiller H, Wiles D, Russell J, Casavant M. Review of toxicity and trends in the use of tiagabine as reported to US poison centers from 2000 to 2012. Hum Exp Toxicol. 2016;35:109-13 pubmed publisher..The frequency of tiagabine cases in NPDS mirrored pharmaceutical sales, with steep declines temporally related to the 2005 FDA warning. ..
- Kitzman P, Uhl T, Dwyer M. Gabapentin suppresses spasticity in the spinal cord-injured rat. Neuroscience. 2007;149:813-21 pubmed..Gabapentin diminishes both the behavioral and electrophysiological manifestation of SCI-induced spasticity, in the tail musculature, in a time dependent manner. ..
- Buckley M, Reeves B, Barletta J, Bikin D. Correlation of Free and Total Phenytoin Serum Concentrations in Critically Ill Patients. Ann Pharmacother. 2016;50:276-81 pubmed publisher..This imprecision may lead to inaccurate decision making regarding the management of phenytoin in this patient population. Thus, free phenytoin levels should be utilized. ..
- Nance P. Alpha adrenergic and serotonergic agents in the treatment of spastic hypertonia. Phys Med Rehabil Clin N Am. 2001;12:889-905 pubmed..6. Initiate therapy with a low dosage, and titrate judiciously. 7. Stop the titration when functional goal is achieved. 8. If goal is not achieved or if side effects are intolerable, consider a second medication. ..
- Rhodes M, Frye C. Progestins in the hippocampus of female rats have antiseizure effects in a pentylenetetrazole seizure model. Epilepsia. 2004;45:1531-8 pubmed..Together, these data suggest that P can have antiseizure effects, and these effects may be due in part to actions of its metabolite, 3alpha,5alpha-THP, in the hippocampus. ..
- Salinsky M, Spencer D, Oken B, Storzbach D. Effects of oxcarbazepine and phenytoin on the EEG and cognition in healthy volunteers. Epilepsy Behav. 2004;5:894-902 pubmed..The only significant difference between AEDs was for the POMS-Vigor scale, favoring OXC. The small sample size may have contributed to the lack of significant differences between AEDs. ..
- Miller A, Prost V, Bookstaver P, Gaines K. Topiramate-induced myoclonus and psychosis during migraine prophylaxis. Am J Health Syst Pharm. 2010;67:1178-80 pubmed publisher..Myoclonus has not returned. A patient with cerebral palsy experienced myoclonus and acute psychosis after receiving a standard dosage of topiramate for migraine prophylaxis. ..
- Williams E, Carlson J, Lai W, Wong Y, Yoshimura T, Critchley D, et al. Investigation of the metabolism of rufinamide and its interaction with valproate. Drug Metab Lett. 2011;5:280-9 pubmed..Carboxylesterases were not significantly inhibited by CGP 47292. Inhibition of in vitro rufinamide hydrolysis by valproate could offer an explanation for the observed in vivo drug-drug interaction between the two antiepileptic drugs. ..
- Ponnala S, Chaudhari J, Jaleel M, Bhiladvala D, Kaipa P, Das U, et al. Role of MDR1 C3435T and GABRG2 C588T gene polymorphisms in seizure occurrence and MDR1 effect on anti-epileptic drug (phenytoin) absorption. Genet Test Mol Biomarkers. 2012;16:550-7 pubmed publisher..Moreover, the MDR1 3435T allele also affects PHT absorption. We suggest MDR1 C3435T and GABRG2 C588T genotyping would be of value in order to lower the risk of concentration-dependent drug toxicity and for better patient management. ..
- Hartung D, Middleton L, Svoboda L, McGregor J. Generic substitution of lamotrigine among medicaid patients with diverse indications: a cohort-crossover study. CNS Drugs. 2012;26:707-16 pubmed publisher..87, 3.51). A statistically significant increase in ED visits, hospitalizations or condition-specific encounters was not observed following the switch from brand to generic lamotrigine, although a type II error cannot be ruled out. ..
- Bryndziar T, Sedová P, Kramer N, Mandrekar J, Mikulik R, Brown R, et al. Seizures Following Ischemic Stroke: Frequency of Occurrence and Impact on Outcome in a Long-Term Population-Based Study. J Stroke Cerebrovasc Dis. 2016;25:150-6 pubmed publisher..Seizure occurrence did not differ based on IS etiologic subtype or stroke risk factors. ..
- Quarum M, Parker J, Keana J, Weber E. (+)-[3H]MK-801 binding sites in postmortem human brain. J Neurochem. 1990;54:1163-8 pubmed..However, all compounds tested showed greater potency at the high-affinity site in cortex. The results indicate that (+)-[3H]MK-801 binding in human postmortem brain tissue shows pharmacological and regional specificity. ..
- Weinshenker D, Szot P, Miller N, Palmiter R. Alpha(1) and beta(2) adrenoreceptor agonists inhibit pentylenetetrazole-induced seizures in mice lacking norepinephrine. J Pharmacol Exp Ther. 2001;298:1042-8 pubmed..Endogenous NE probably does not activate the beta(2)AR under these conditions, but exogenous activation of the beta(2)AR produces an anticonvulsant effect. ..
- Huddleston J, Sanchez Ramos L, Huddleston K. Acute management of preterm labor. Clin Perinatol. 2003;30:803-24, vii pubmed..This article concentrates on the clinical diagnosis and acute management of this enigmatic clinical problem. ..
- Breza T, Zheng P, Porcu P, Magro C. Cutaneous marginal zone B-cell lymphoma in the setting of fluoxetine therapy: a hypothesis regarding pathogenesis based on in vitro suppression of T-cell-proliferative response. J Cutan Pathol. 2006;33:522-8 pubmed..Fluoxetine may be associated with pseudolymphomata and marginal zone lymphoma. The inhibitory effects on T-lymphocyte function and more specifically T-suppressor function may lead to excessive antigen-driven B-cell proliferation. ..
- Vossler D, Conry J, Murphy J. Zonisamide for the treatment of myoclonic seizures in progressive myoclonic epilepsy: an open-label study. Epileptic Disord. 2008;10:31-4 pubmed publisher..These results suggest that zonisamide may be useful in the treatment of patients with PME. However, due to the size and open-label character of this study, further research is required. ..
- Elliott J. Possible methods for the prevention of bone loss in persons with epilepsy. Expert Rev Neurother. 2009;9:797-812 pubmed publisher..Consensus guidelines are needed for the prevention, screening and treatment of BMD loss in epilepsy...
- Boison D, Chen J, Fredholm B. Adenosine signaling and function in glial cells. Cell Death Differ. 2010;17:1071-82 pubmed publisher..Eventually, glial adenosine-modulating drug targets might be an attractive alternative for the treatment of neurodegenerative diseases. There are, however, several major open questions that remain to be tackled. ..
- Boison D. Modulators of nucleoside metabolism in the therapy of brain diseases. Curr Top Med Chem. 2011;11:1068-86 pubmed..Finally, novel gene-based therapeutic strategies to inhibit nucleoside metabolism and focal treatment approaches will be discussed. ..
- Griss R, Schena A, Reymond L, Patiny L, Werner D, Tinberg C, et al. Bioluminescent sensor proteins for point-of-care therapeutic drug monitoring. Nat Chem Biol. 2014;10:598-603 pubmed publisher..This low-cost point-of-care method could make therapies safer, increase the convenience of doctors and patients and make therapeutic drug monitoring available in regions with poor infrastructure. ..
- Galligan J, North R. MK-801 blocks nicotinic depolarizations of guinea pig myenteric neurons. Neurosci Lett. 1990;108:105-9 pubmed..It is concluded that MK-801 can act as a non-competitive antagonist of nicotinic responses in myenteric neurons. ..
- Reoux J, Saxon A, Malte C, Baer J, Sloan K. Divalproex sodium in alcohol withdrawal: a randomized double-blind placebo-controlled clinical trial. Alcohol Clin Exp Res. 2001;25:1324-9 pubmed..A more aggressive loading dose strategy may demonstrate a more robust or earlier response. ..
- Bartha A, Shen J, Katz K, Mischel R, Yap K, Ivacko J, et al. Neonatal seizures: multicenter variability in current treatment practices. Pediatr Neurol. 2007;37:85-90 pubmed..Trials of anticonvulsants with long-term neurodevelopmental follow-up are needed to develop evidence-based treatment guidelines. ..
- Sheth R, Binkley N, Hermann B. Gender differences in bone mineral density in epilepsy. Epilepsia. 2008;49:125-31 pubmed..Age at onset of epilepsy, growth trends, and hormonal differences may underlie these gender differences. Lower bone accrual in adolescence may contribute to increased fracture risk for both men and women with epilepsy. ..
- Liu C, Xanthopoulos P, Chaovalitwongse W, Pardalos P, Uthman B. Antiepileptic drug intervention decouples electroencephalogram (EEG) signals: a case study in Unverricht-Lundborg Disease. Conf Proc IEEE Eng Med Biol Soc. 2008;2008:2108-11 pubmed publisher..This finding could lead to a new insight for developing a new outcome measure for patient with ULD, when UMRS could potentially fail to detect a significant difference. ..
- Devinsky O, Dilley C, Ozery Flato M, Aharonov R, Goldschmidt Y, Rosen Zvi M, et al. Changing the approach to treatment choice in epilepsy using big data. Epilepsy Behav. 2016;56:32-7 pubmed publisher..Our goal will be to strengthen the predictive power of the model by integrating diverse data sets and potentially moving to prospective data collection. ..
- Becker H, Veatch L. Effects of lorazepam treatment for multiple ethanol withdrawals in mice. Alcohol Clin Exp Res. 2002;26:371-80 pubmed
- Costa L, Aschner M, Vitalone A, Syversen T, Soldin O. Developmental neuropathology of environmental agents. Annu Rev Pharmacol Toxicol. 2004;44:87-110 pubmed..Additionally, the issue of silent neurotoxicity, i.e., persistent morphological and/or biochemical injury that remains clinically unapparent until later in life, is discussed. ..
- Sheth R. Bone health in pediatric epilepsy. Epilepsy Behav. 2004;5 Suppl 2:S30-5 pubmed..The literature related to bone health in pediatric epilepsy is reviewed, although it should be noted that these data are limited. ..
- Lyons K, Pahwa R. Pharmacotherapy of essential tremor : an overview of existing and upcoming agents. CNS Drugs. 2008;22:1037-45 pubmed publisher..Several new drugs, including 1-octanol, sodium oxybate, dimethoxymethyl-diphenyl-barbituric acid (T-2000) and carisbamate, are currently under investigation for the treatment of essential tremor. ..
- Elble R, Deuschl G. An update on essential tremor. Curr Neurol Neurosci Rep. 2009;9:273-7 pubmed..The evidence is discussed in this update. Recent advances in the treatment of this condition are also reviewed. ..
- Gidal B, Ferry J, Majid O, Hussein Z. Concentration-effect relationships with perampanel in patients with pharmacoresistant partial-onset seizures. Epilepsia. 2013;54:1490-7 pubmed publisher..Understanding these relationships between perampanel plasma concentration and clinical response will be valuable in utilizing this novel AED. ..
- Ghosh C, Hossain M, Puvenna V, Martinez Gonzalez J, Alexopolous A, Janigro D, et al. Expression and functional relevance of UGT1A4 in a cohort of human drug-resistant epileptic brains. Epilepsia. 2013;54:1562-70 pubmed publisher..These initial results suggest the presence of a phase II enzyme in the epileptic brain. Further studies are required to fully describe the pattern of brain UGT1A4 expression in relation to clinical variables and drug resistance. ..
- Naritoku D, Warnock C, Messenheimer J, Borgohain R, Evers S, Guekht A, et al. Lamotrigine extended-release as adjunctive therapy for partial seizures. Neurology. 2007;69:1610-8 pubmed..Results support the clinical utility of this new once-daily formulation. ..
- Stafstrom C, Roopra A, Sutula T. Seizure suppression via glycolysis inhibition with 2-deoxy-D-glucose (2DG). Epilepsia. 2008;49 Suppl 8:97-100 pubmed publisher..Finally, 2DG has a favorable preliminary toxicity profile. These factors support the possibility that 2DG or other modifiers of glycolysis can be used as novel treatments for epilepsy. ..
- Hall S, Yang M, Gates M, Steers W, Tennstedt S, McKinlay J. Associations of commonly used medications with urinary incontinence in a community based sample. J Urol. 2012;188:183-9 pubmed publisher..96, 5.10). Although a cross-sectional analysis cannot determine causality, our analysis suggests certain medications should be further examined in longitudinal analyses of risk to determine their influence on urological symptoms. ..
- Reuben A, Koch D, Lee W. Drug-induced acute liver failure: results of a U.S. multicenter, prospective study. Hepatology. 2010;52:2065-76 pubmed publisher..DILI is an uncommon cause of ALF that evolves slowly, affects a disproportionate number of women and minorities, and shows infrequent spontaneous recovery, but transplantation affords excellent survival. ..
- Empey P, Velez de Mendizabal N, Bell M, Bies R, Anderson K, Kochanek P, et al. Therapeutic hypothermia decreases phenytoin elimination in children with traumatic brain injury. Crit Care Med. 2013;41:2379-87 pubmed publisher..Pharmacokinetic interactions between hypothermia and medications should be considered when caring for children receiving this therapy. ..
- Varon D, Pritchard P, Wagner M, Topping K. Transient Kluver-Bucy syndrome following complex partial status epilepticus. Epilepsy Behav. 2003;4:348-51 pubmed..We present the case of a patient with no evidence of a structural lesion in the temporal lobes and behavioral changes consistent with Kluver-Bucy syndrome following complex partial status epilepticus. ..
- Hemenway J, Nti Addae K, Guarino V, Stella V. Preparation, characterization and in vivo conversion of new water-soluble sulfenamide prodrugs of carbamazepine. Bioorg Med Chem Lett. 2007;17:6629-32 pubmed..Physicochemical characterization and in vivo conversion of a new prodrug of CBZ was evaluated to further establish the proof of concept of the sulfenamide prodrug approach. ..
- Marchi N, Betto G, Fazio V, Fan Q, Ghosh C, Machado A, et al. Blood-brain barrier damage and brain penetration of antiepileptic drugs: role of serum proteins and brain edema. Epilepsia. 2009;50:664-77 pubmed publisher..If confirmed in drug-resistant models, these mechanisms could contribute to drug brain distribution in refractory epilepsies. ..
- Kim H, Thurman D, Durgin T, Faught E, Helmers S. Estimating Epilepsy Incidence and Prevalence in the US Pediatric Population Using Nationwide Health Insurance Claims Data. J Child Neurol. 2016;31:743-9 pubmed publisher..The findings appear reasonably representative of the US-insured pediatric population. ..
- Deshmukh U, Adams J, Macklin E, Dhillon R, McCarthy K, Dworetzky B, et al. Behavioral outcomes in children exposed prenatally to lamotrigine, valproate, or carbamazepine. Neurotoxicol Teratol. 2016;54:5-14 pubmed publisher..Faced with difficult choices, clinicians should be supportive as these patients consider their options. ..
- ..Interventional techniques play a limited role in the management of PHN although some data indicate that Intrathecal methylprednisolone and spinal cord stimulation may be effective. ..
- Radhakrishnan K, St Louis E, Johnson J, McClelland R, Westmoreland B, Klass D. Pattern-sensitive epilepsy: electroclinical characteristics, natural history, and delineation of the epileptic syndrome. Epilepsia. 2005;46:48-58 pubmed
- Sajatovic M, Jenkins J, Cassidy K, Muzina D. Medication treatment perceptions, concerns and expectations among depressed individuals with Type I Bipolar Disorder. J Affect Disord. 2009;115:360-6 pubmed publisher..Subjective experience with medications using qualitative and quantitative methods should be explored in order to optimize treatment collaboration and outcomes. ..
- Kotagal S, Broomall E. Sleep in children with autism spectrum disorder. Pediatr Neurol. 2012;47:242-51 pubmed publisher..The clinical assessment of sleep problems in this population and a management algorithm are presented. ..
- Anderson G. Pharmacokinetic, pharmacodynamic, and pharmacogenetic targeted therapy of antiepileptic drugs. Ther Drug Monit. 2008;30:173-80 pubmed publisher..Identification of experimental and clinical evidence linking functional changes associated with gene mutations to epilepsy syndromes will help provide new molecular targets for future AEDs. ..
- Meador K, Baker G, Finnell R, Kalayjian L, Liporace J, Loring D, et al. In utero antiepileptic drug exposure: fetal death and malformations. Neurology. 2006;67:407-12 pubmed..These results combined with several recent studies provide strong evidence that valproate poses the highest risk to the fetus. For women who fail other AEDs and require valproate, the dose should be limited if possible. ..
- Sahaya K, Goyal M, Sarwal A, Singh N. Levetiracetam-induced thrombocytopenia among inpatients: a retrospective study. Epilepsia. 2010;51:2492-5 pubmed publisher..A single patient had clear temporal co-relation and association of thrombocytopenia with LEV therapy. LEV-induced thrombocytopenia is a rare but reversible complication of LEV therapy. The mechanism remains unknown. ..
- Buckmaster P, Haney M. Factors affecting outcomes of pilocarpine treatment in a mouse model of temporal lobe epilepsy. Epilepsy Res. 2012;102:153-9 pubmed publisher..Those results are substantially better than that of the total sample in which 31% failed to develop status epilepticus and only 34% developed status epilepticus and survived. ..
- Alexopoulos A, Lachhwani D, Gupta A, Kotagal P, Harrison A, Bingaman W, et al. Resective surgery to treat refractory status epilepticus in children with focal epileptogenesis. Neurology. 2005;64:567-70 pubmed..At follow-up (median 7 months), 7 (70%) of 10 patients were seizure free, and 3 (30%) of 10 had significant improvement in their epilepsy. ..
- Scher M, Alvin J, Gaus L, Minnigh B, Painter M. Uncoupling of EEG-clinical neonatal seizures after antiepileptic drug use. Pediatr Neurol. 2003;28:277-80 pubmed..Serial electroencephalographic monitoring helps document continued electrographic seizure expression after antiepileptic drug use, following complete or partial suppression of clinical seizure behaviors. ..
- Compton R, Spiller H, Bosse G. Fatal fluoxetine ingestion with postmortem blood concentrations. Clin Toxicol (Phila). 2005;43:277-9 pubmed..No other drugs were detected. We report an unusual case of massive fluoxetine ingestion resulting in neurological and cardiovascular toxicity resulting in death. ..
- Findling R. Pharmacologic treatment of behavioral symptoms in autism and pervasive developmental disorders. J Clin Psychiatry. 2005;66 Suppl 10:26-31 pubmed..This article discusses the efficacy and tolerability of various medications and alternative interventions in addressing the symptoms of autism and other PDDs. ..
- Suarez J. [Treatment of acute brain edema]. Rev Neurol. 2001;32:275-81 pubmed..Recently new, effective therapy has been evaluated which may substantially change current concepts of the treatment of patients with acute cerebral edema. ..
- Gao K, Kemp D, Ganocy S, Muzina D, Xia G, Findling R, et al. Treatment-emergent mania/hypomania during antidepressant monotherapy in patients with rapid cycling bipolar disorder. Bipolar Disord. 2008;10:907-15 pubmed publisher..Use of second-generation antidepressants as monotherapy in RCBD is accompanied by clinically relevant rates of TEM. Even in patients with RCBD, differential vulnerabilities to antidepressant TEM may exist. ..
- Cook A, Zafar M, Mathias S, Stewart A, Albuja A, Bensalem Owen M, et al. Pharmacokinetics and Clinical Utility of Valproic Acid Administered via Continuous Infusion. CNS Drugs. 2016;30:71-7 pubmed publisher..Continuous infusion valproic acid appears to be a safe, effective, and predictable manner by which to administer valproic acid to pediatric and adult patients admitted to the hospital. ..
- Fadul C, Meyer L, Jobst B, Cornell C, Lewis L. Agranulocytosis associated with lamotrigine in a patient with low-grade glioma. Epilepsia. 2002;43:199-200 pubmed..In this case, the use of LTG was associated with the development of agranulocytosis, and it is likely that this association was causative. ..
- Celesia G. Are the epilepsies disorders of ion channels?. Lancet. 2003;361:1238-9 pubmed
- Pinto E, Dolzan M, Cabral L, Armstrong D, de Sousa V. Topiramate: A Review of Analytical Approaches for the Drug Substance, Its Impurities and Pharmaceutical Formulations. J Chromatogr Sci. 2016;54:280-90 pubmed publisher..Each of these methods is briefly discussed, especially considering the detector used with HPLC. In addition, this article presents a review of the data available regarding topiramate stability, degradation products and impurities. ..
- Sheth K, Martini S, Moomaw C, Koch S, Elkind M, Sung G, et al. Prophylactic Antiepileptic Drug Use and Outcome in the Ethnic/Racial Variations of Intracerebral Hemorrhage Study. Stroke. 2015;46:3532-5 pubmed publisher..74-1.65; P=0.62). We found no evidence that AED use (predominantly levetiracetam) is independently associated with poor outcome. A prospective study is required to assess for a more modest effect of AED use on outcome after ICH. ..
- Lyons K, Pahwa R, Comella C, Eisa M, Elble R, Fahn S, et al. Benefits and risks of pharmacological treatments for essential tremor. Drug Saf. 2003;26:461-81 pubmed..The use of medication and/or surgery can provide adequate tremor control in the majority of the patients. ..
- Baldessarini R, Vieta E, Calabrese J, Tohen M, Bowden C. Bipolar depression: overview and commentary. Harv Rev Psychiatry. 2010;18:143-57 pubmed publisher..Interest in recognizing bipolar depression and seeking more effective, specific, and safer treatments for it are growing. ..
- Zafar R, King M, Carney P. Adeno associated viral vector-mediated expression of somatostatin in rat hippocampus suppresses seizure development. Neurosci Lett. 2012;509:87-91 pubmed publisher..These preclinical results suggest a putative role for SST as an anticonvulsant therapeutic modality for epilepsy. ..
- Appleby B, Nacopoulos D, Milano N, Zhong K, Cummings J. A review: treatment of Alzheimer's disease discovered in repurposed agents. Dement Geriatr Cogn Disord. 2013;35:1-22 pubmed publisher..Known MOA, toxicology, and pharmacodynamic profiles would accelerate the process and increase the odds of finding a more timely disease-modifying treatment for AD. ..
- Shiner B, Westgate C, Bernardy N, Schnurr P, Watts B. Anticonvulsant Medication Use in Veterans With Posttraumatic Stress Disorder. J Clin Psychiatry. 2017;78:e545-e552 pubmed publisher..However, this may be appropriate use driven by increased prevalence of comorbid conditions that may be an indication for anticonvulsant use, including pain and headache disorders. ..
- Osorio I, Reed R, Peltzer J. Refractory idiopathic absence status epilepticus: A probable paradoxical effect of phenytoin and carbamazepine. Epilepsia. 2000;41:887-94 pubmed..These findings underscore the value of accurate classification of seizures and particularly the syndromic approach to diagnosis and point to the potential for iatrogenic complications with indiscriminate use of antiseizure drugs. ..
- Malcolm R, Myrick H, Roberts J, Wang W, Anton R, Ballenger J. The effects of carbamazepine and lorazepam on single versus multiple previous alcohol withdrawals in an outpatient randomized trial. J Gen Intern Med. 2002;17:349-55 pubmed..Carbamazepine, however, was superior to lorazepam in preventing rebound withdrawal symptoms and reducing post-treatment drinking, especially for those with a history of multiple treated withdrawals. ..
- Shinoda S, Araki T, Lan J, Schindler C, Simon R, Taki W, et al. Development of a model of seizure-induced hippocampal injury with features of programmed cell death in the BALB/c mouse. J Neurosci Res. 2004;76:121-8 pubmed..These data refine our C57BL/6 model and establish a companion model of focally evoked limbic seizures in the BALB/c mouse that provides further evidence for activation of programmed cell death after seizures. ..
- Danhauer S, Miller C, Rhodus N, Carlson C. Impact of criteria-based diagnosis of burning mouth syndrome on treatment outcome. J Orofac Pain. 2002;16:305-11 pubmed..These data indicate that while BMS and OB groups may initially present with similar clinical and psychosocial features, they are distinguishable with careful diagnosis that often enables successful management of symptoms for each group. ..
- Pahwa R, Lyons K. Essential tremor: differential diagnosis and current therapy. Am J Med. 2003;115:134-42 pubmed..Patients with medication-resistant tremor may benefit from thalamotomy or deep brain stimulation of the thalamus. The use of medical and surgical therapies can provide benefit in up to 80% of patients with essential tremor. ..
- Foldvary Schaefer N, Falcone T. Catamenial epilepsy: pathophysiology, diagnosis, and management. Neurology. 2003;61:S2-15 pubmed..Larger multicenter trials, as well as further investigation of the pathophysiology of the disorder, are needed to identify the most effective treatment for women with catamenial epilepsy. ..
- Kluger B, Meador K. Teratogenicity of antiepileptic medications. Semin Neurol. 2008;28:328-35 pubmed publisher..Management of women with epilepsy should include a discussion of these risks, prophylactic treatment with folic acid, and the minimal use of polypharmacy and valproate needed to maintain optimum seizure control. ..
- Li X, Ricci R, Large C, Anderson B, Nahas Z, Bohning D, et al. Interleaved transcranial magnetic stimulation and fMRI suggests that lamotrigine and valproic acid have different effects on corticolimbic activity. Psychopharmacology (Berl). 2010;209:233-44 pubmed publisher..The study demonstrates that a combination of TMS and fMRI techniques may be useful in the study of the effects of neuroactive drugs on specific brain circuits. ..
- Iuorno J, Kolostyak K, Mejico L. Therapies with potential toxicity of neuro-ophthalmic interest. Curr Opin Ophthalmol. 2003;14:339-43 pubmed..Appropriate management requires prompt recognition of these associations. Practitioners should be familiar with these neuro-ophthalmic manifestations because they may present in the course of daily practice. ..
- Koubeissi M, Maciunas R, Tanner A, Lüders H. Medically intractable seizures originating from the primary somatosensory hand area. Epileptic Disord. 2008;10:339-48 pubmed publisher..Multiple subpial transections of that area are sometimes performed to minimize functional deficits, but seizure control may be less optimal than with cortical resection. ..
- Marchi N, Granata T, Ghosh C, Janigro D. Blood-brain barrier dysfunction and epilepsy: pathophysiologic role and therapeutic approaches. Epilepsia. 2012;53:1877-86 pubmed publisher..We also present BBB neuroimaging as a tool to correlate BBB restoration to seizure mitigation. Add-on cerebrovascular drug could be of efficacy in reducing seizure burden when used in association with neuronal antiepileptic drugs. ..
- Meyer J, Fardo D, Fleming S, Hopenhayn C, Gokun Y, Ryan M. Generic antiepileptic drug prescribing: a cross-sectional study. Epilepsy Behav. 2013;26:1-6 pubmed publisher..6% decreased odds of receiving a generic AED (OR = 0.874; C I= 0.821-0.931). These patient characteristics could signify certain health care disparities and may represent potential confounders to future observational studies. ..
- Schuurs Hoeijmakers J, Landsverk M, Foulds N, Kukolich M, Gavrilova R, Greville Heygate S, et al. Clinical delineation of the PACS1-related syndrome--Report on 19 patients. Am J Med Genet A. 2016;170:670-5 pubmed publisher..There is persistence of oral motor dysfunction. We provide suggestions for clinical work-up and management and hope that the present study will facilitate clinical recognition of further cases. ..
- Hant F, Bolster M. Drugs that may harm bone: Mitigating the risk. Cleve Clin J Med. 2016;83:281-8 pubmed publisher..Healthcare providers should monitor the bone health of patients on these agents, supplement their intake of calcium and vitamin D, encourage weight-bearing exercise, and initiate osteoporosis-prevention treatment as indicated. ..
- Dubiel A, Kulesza R. Prenatal valproic acid exposure disrupts tonotopic c-Fos expression in the rat brainstem. Neuroscience. 2016;324:511-23 pubmed publisher..Based on these findings, we suggest that such abnormal patterns of activation may play a role in auditory processing deficits in ASD. ..
- Lim L, Foldvary N, Mascha E, Lee J. Acetazolamide in women with catamenial epilepsy. Epilepsia. 2001;42:746-9 pubmed..A loss of efficacy over 6-24 months was reported by 15% of women. Despite our small sample and retrospective design, AZ appears to demonstrate efficacy for catamenial epilepsy. ..