Genomes and Genes
Experts and Doctors on animals in United States
Locale: United States
Publications2253 found, 100 shown here
- Martin L, Glasper E, Nelson R, Devries A. Prolonged separation delays wound healing in monogamous California mice, Peromyscus californicus, but not in polygynous white-footed mice, P. leucopus. Physiol Behav. 2006;87:837-41 pubmed..In sum, our results suggest that positive social interactions may be important for promoting immune activity in some species. ..
- Jiao Z, De Jesus V, Iravanian S, Campbell D, Xu J, Vitali J, et al. A possible mechanism of halocarbon-induced cardiac sensitization arrhythmias. J Mol Cell Cardiol. 2006;41:698-705 pubmed..The slowing of conduction is most likely related to changes in the phosphorylation state of Cx43. ..
- Helwig B, Musch T, Craig R, Kenney M. Increased interleukin-6 receptor expression in the paraventricular nucleus of rats with heart failure. Am J Physiol Regul Integr Comp Physiol. 2007;292:R1165-73 pubmed..Rather the increased IL-6 levels characteristic of HF may alter PVN-mediated physiological responses via enhanced expression of the IL-6R. ..
- Macarthur C, Pillers D, Pang J, DeGagne J, Kempton J, Trune D. Gram-negative pathogen Klebsiella oxytoca is associated with spontaneous chronic otitis media in Toll-like receptor 4-deficient C3H/HeJ mice. Acta Otolaryngol. 2008;128:132-8 pubmed..Electron microscopy of the middle ears revealed abundant rod-shaped Klebsiella bacteria, both free and being engulfed by neutrophils. ..
- Aquilina Beck A, Ilagan K, Liu Q, Liang J. Nodal signaling is required for closure of the anterior neural tube in zebrafish. BMC Dev Biol. 2007;7:126 pubmed
- Turner M, Jellison E, Lingenheld E, Puddington L, Lefrancois L. Avidity maturation of memory CD8 T cells is limited by self-antigen expression. J Exp Med. 2008;205:1859-68 pubmed publisher..Thus, the self-reactive T cell repertoire is controlled by overlapping mechanisms influenced by antigen dose. ..
- Swanlund J, Kregel K, Oberley T. Autophagy following heat stress: the role of aging and protein nitration. Autophagy. 2008;4:936-9 pubmed
- Perez G, Roumillat W, Levesque E, Connors V, de Buron I. Synchronization of occurrence of the ovarian philometrid, Philometra carolinensis, with the spawning season of its fish host, the spotted seatrout, Cynoscion nebulosus. Parasitol Res. 2009;104:1079-85 pubmed publisher..The data show that development of this parasite is linked to the host's reproductive status and suggest that paratenesis plays an important role in the maintenance of the parasite's life cycle...
- Lee M, Veiseh O, Bhattarai N, Sun C, Hansen S, Ditzler S, et al. Rapid pharmacokinetic and biodistribution studies using cholorotoxin-conjugated iron oxide nanoparticles: a novel non-radioactive method. PLoS ONE. 2010;5:e9536 pubmed publisher..The nanoparticles tested demonstrate properties that are excellent for future clinical imaging strategies and potentially suitable for targeted therapy. ..
- King C, Olbrych S, Soon M, Singer M, Carter J, Colley D. Utility of repeated praziquantel dosing in the treatment of schistosomiasis in high-risk communities in Africa: a systematic review. PLoS Negl Trop Dis. 2011;5:e1321 pubmed publisher..In a systematic review of published studies, we examined evidence for incremental benefits from repeated praziquantel dosing, given 2 to 8 weeks after an initial dose, in Schistosoma-endemic areas of Africa...
- Zhou Z, Li K, Rieck D, Ouyang Y, Chandra M, Dong W. Structural dynamics of C-domain of cardiac troponin I protein in reconstituted thin filament. J Biol Chem. 2012;287:7661-74 pubmed publisher..In contrast, the IR responds to Ca(2+) signals with slow structural dynamics and transition kinetics. The collective findings suggested a fourth state of activation. ..
- Zannino D, SAGERSTROM C, Appel B. olig2-Expressing hindbrain cells are required for migrating facial motor neurons. Dev Dyn. 2012;241:315-26 pubmed publisher..Our data raise the possibility that cells expressing olig2 are intermediate targets that help guide facial motor neuron migration. ..
- Kim M, Shu Y, Carsillo T, Zhang J, Yu L, Peterson C, et al. hsp70 and a novel axis of type I interferon-dependent antiviral immunity in the measles virus-infected brain. J Virol. 2013;87:998-1009 pubmed publisher..Collectively, our results support a novel axis of type I IFN-dependent antiviral immunity in the virus-infected brain that is driven by hsp70. ..
- Slater B, Willis A, Llano D. Evidence for layer-specific differences in auditory corticocollicular neurons. Neuroscience. 2013;229:144-54 pubmed publisher..The marked differences in physiological properties and dendritic arborization between neurons in layers 5 and 6 make it likely that each type plays a distinct role in controlling auditory information processing in the midbrain. ..
- Maimaitiyiming H, Li Y, Cui W, Tong X, Norman H, Qi X, et al. Increasing cGMP-dependent protein kinase I activity attenuates cisplatin-induced kidney injury through protection of mitochondria function. Am J Physiol Renal Physiol. 2013;305:F881-90 pubmed publisher..Taken together, these results suggest that increasing PKG activity may be a novel option for renoprotection during cisplatin-based chemotherapy. ..
- Nutter T, Johnson R, Cooper B. A delayed chronic pain like condition with decreased Kv channel activity in a rat model of Gulf War Illness pain syndrome. Neurotoxicology. 2015;51:67-79 pubmed publisher..The decline in activity of muscle nociceptor KDR and Kv7 channel proteins was consistent with increased nociceptor excitability and a delayed myalgia in rats exposed to GW chemicals. ..
- Kasl E, McAllister C, Robison H, Connior M, Font W, Criscione C. Evolutionary consequence of a change in life cycle complexity: A link between precocious development and evolution toward female-biased sex allocation in a hermaphroditic parasite. Evolution. 2015;69:3156-70 pubmed publisher..These results emphasize how changes in life cycle patterns that alter mating systems can impact the evolution of reproductive traits in parasites. ..
- Leduc R, Molloy S, Thorne B, Thomas G. Activation of human furin precursor processing endoprotease occurs by an intramolecular autoproteolytic cleavage. J Biol Chem. 1992;267:14304-8 pubmed..Finally, the production of 90-kDa furin from either site-directed furin mutant could not be potentiated by overexpressing active furin, suggesting that the autoproteolytic activation was an intramolecular event. ..
- Fini M, Karmilowicz M, Ruby P, Beeman A, Borges K, Brinckerhoff C. Cloning of a complementary DNA for rabbit proactivator. A metalloproteinase that activates synovial cell collagenase, shares homology with stromelysin and transin, and is coordinately regulated with collagenase. Arthritis Rheum. 1987;30:1254-64 pubmed..Our data suggest the existence of coordinately regulated metalloproteinases that are important in the modulation of connective tissue metabolism. ..
- Spieker Polet H, Yam P, Knight K. Differential expression of 13 IgA-heavy chain genes in rabbit lymphoid tissues. J Immunol. 1993;150:5457-65 pubmed
- Huang D, Wang J, Kivisakk P, Rollins B, Ransohoff R. Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis. J Exp Med. 2001;193:713-26 pubmed
- Weaver Osterholtz D, Reams G, De Vergel C, Bauer J. The bladder angiotensin system in female rats: response to infusions of angiotensin I and the angiotensin converting enzyme inhibitor enalaprilat. J Urol. 2001;165:1735-8 pubmed..Enalapril appears to have more effect at the tissue level in nonpregnant females than in pregnant females and male rats. ..
- McLaughlin J, Marton Popovici M, Chavkin C. Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses. J Neurosci. 2003;23:5674-83 pubmed..The findings suggest that chronic swim stress may activate the kappa opioid system to produce analgesia, immobility, and potentiation of the acute rewarding properties of cocaine in C57Bl/6 mice. ..
- Yang A, Sonin D, Jones L, Barry W, Liang B. A beneficial role of cardiac P2X4 receptors in heart failure: rescue of the calsequestrin overexpression model of cardiomyopathy. Am J Physiol Heart Circ Physiol. 2004;287:H1096-103 pubmed..The increased contractility likely underlies the survival benefit from P2X4 receptor overexpression. An increased expression or activation of this receptor may represent a new approach in the therapy of heart failure. ..
- Haigis K, Hoff P, White A, Shoemaker A, Halberg R, Dove W. Tumor regionality in the mouse intestine reflects the mechanism of loss of Apc function. Proc Natl Acad Sci U S A. 2004;101:9769-73 pubmed..Perhaps, the power of mouse genetics and biology can be harnessed to identify genetic and other factors that contribute to tumor regionality. ..
- Lohr H, Kuntchithapautham K, Sharma A, Rohrer B. Multiple, parallel cellular suicide mechanisms participate in photoreceptor cell death. Exp Eye Res. 2006;83:380-9 pubmed..Thus, unless the common upstream initiator for a given photoreceptor dystrophy is found, multiple rescue paradigms need to be used to target all active pathways. ..
- Hu X, Eszterhas S, Pallazzi N, Bouhassira E, Fields J, Tanabe O, et al. Transcriptional interference among the murine beta-like globin genes. Blood. 2007;109:2210-6 pubmed
- Xia X, Zhang Y, Zieth C, Zhang S. Transgenes delivered by lentiviral vector are suppressed in human embryonic stem cells in a promoter-dependent manner. Stem Cells Dev. 2007;16:167-76 pubmed..Cautions should be taken to choose the optimal promoter when lentiviruses are used for genetic modification of human ES cells. ..
- Seyb K, Ansar S, Li G, Bean J, Michaelis M, Dobrowsky R. p35/Cyclin-dependent kinase 5 is required for protection against beta-amyloid-induced cell death but not tau phosphorylation by ceramide. J Mol Neurosci. 2007;31:23-35 pubmed..However, ceramide blocked tau hyperphosphorylation potentially via inhibition of glycogen synthase kinase-3beta. These data suggest that ceramide can regulate A beta cell toxicity in a p35/cdk5-dependent manner. ..
- Smith C, Fan G. The saga of JAK2 mutations and translocations in hematologic disorders: pathogenesis, diagnostic and therapeutic prospects, and revised World Health Organization diagnostic criteria for myeloproliferative neoplasms. Hum Pathol. 2008;39:795-810 pubmed publisher..Also discussed are the JAK2 inhibitors for clinical trials. Finally, the advantages of the newly proposed World Health Organization classification for myeloproliferative neoplasms are reviewed. ..
- Balijepalli R, Kamp T. Caveolae, ion channels and cardiac arrhythmias. Prog Biophys Mol Biol. 2008;98:149-60 pubmed publisher..This review highlights the existing evidence identifying and characterizing ion channels localized to caveolae in cardiomyocytes and their role in arrhythmogenesis. ..
- Gleason E, Fuxjager M, Oyegbile T, Marler C. Testosterone release and social context: when it occurs and why. Front Neuroendocrinol. 2009;30:460-9 pubmed publisher..We discuss how the functions of testosterone may overlap in some contexts...
- Bao X, Pal R, Hascup K, Wang Y, Wang W, Xu W, et al. Transgenic expression of Glud1 (glutamate dehydrogenase 1) in neurons: in vivo model of enhanced glutamate release, altered synaptic plasticity, and selective neuronal vulnerability. J Neurosci. 2009;29:13929-44 pubmed publisher..The Glud1 mouse might be a useful model for the effects of lifelong excess synaptic Glu release on CNS neurons and for age-associated neurodegenerative processes. ..
- Akada H, Yan D, Zou H, Fiering S, Hutchison R, Mohi M. Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease. Blood. 2010;115:3589-97 pubmed publisher..Our conditional Jak2V617F knock-in mice provide an excellent model that can be used to further understand the molecular pathogenesis of MPNs and to identify additional genetic events that cooperate with Jak2V617F in different MPNs. ..
- Tarsa L, Bałkowiec Iskra E, Kratochvil F, Jenkins V, McLean A, Brown A, et al. Tooth pulp inflammation increases brain-derived neurotrophic factor expression in rodent trigeminal ganglion neurons. Neuroscience. 2010;167:1205-15 pubmed publisher..Overall, the inflammation-induced upregulation of BDNF is stronger in mice compared to rats. Thus, mouse TG provides a suitable model to study molecular mechanisms of inflammation-dependent regulation of BDNF expression in vivo. ..
- Ariyoshi W, Knudson C, Luo N, Fosang A, Knudson W. Internalization of aggrecan G1 domain neoepitope ITEGE in chondrocytes requires CD44. J Biol Chem. 2010;285:36216-24 pubmed publisher..Bovine or wild type mouse fibroblasts were able to bind and internalize bovine-derived G1-ITEGE. Although several pathways are available for the clearance of these domains, CD44-mediated cellular internalization is the most prominent. ..
- Barrie E, Smith R, Sanford J, Sadee W. mRNA transcript diversity creates new opportunities for pharmacological intervention. Mol Pharmacol. 2012;81:620-30 pubmed publisher..Consideration of a gene's transcript diversity should become an integral part of drug design, development, and therapy. ..
- Son Y, Wang L, Poyil P, Budhraja A, Hitron J, Zhang Z, et al. Cadmium induces carcinogenesis in BEAS-2B cells through ROS-dependent activation of PI3K/AKT/GSK-3?/?-catenin signaling. Toxicol Appl Pharmacol. 2012;264:153-60 pubmed publisher..Collectively, our findings suggest a direct involvement of ROS in cadmium-induced carcinogenesis and implicate a role of AKT/GSK-3?/?-catenin signaling in this process...
- Rotschafer S, RAZAK K. Altered auditory processing in a mouse model of fragile X syndrome. Brain Res. 2013;1506:12-24 pubmed publisher..Auditory neural responses can serve as outcome measures in preclinical trials of therapeutics for FXS as well as serve as physiological probes to study their mechanisms of action. ..
- Katzenberger R, Chtarbanova S, Rimkus S, Fischer J, Kaur G, Seppala J, et al. Death following traumatic brain injury in Drosophila is associated with intestinal barrier dysfunction. elife. 2015;4: pubmed publisher..Our results indicate that natural variation in the probability of death following TBI is due in part to genetic differences that affect intestinal barrier dysfunction. ..
- Xie Y, Jin Y, Merenick B, Ding M, Fetalvero K, Wagner R, et al. Phosphorylation of GATA-6 is required for vascular smooth muscle cell differentiation after mTORC1 inhibition. Sci Signal. 2015;8:ra44 pubmed publisher..Identifying the downstream transcriptional targets of mTORC1 may provide cell type-specific drug targets to combat cardiovascular diseases associated with excessive proliferation of VSMCs. ..
- Patel J, Sekharam K, Block E. Oxidant injury increases cell surface receptor binding of angiotensin II to pulmonary artery endothelial cells. J Biochem Toxicol. 1990;5:253-8 pubmed..In cells exposed to phospholipase A2, acetic acid treatment did not release cell-bound Ang II, and the remaining Ang II was recovered in the NaOH solubilized fraction.(ABSTRACT TRUNCATED AT 250 WORDS) ..
- Luke N, Russo T, Luther N, Campagnari A. Use of an isogenic mutant constructed in Moraxella catarrhalis To identify a protective epitope of outer membrane protein B1 defined by monoclonal antibody 11C6. Infect Immun. 1999;67:681-7 pubmed..Further analysis with MAb 11C6 revealed the presence of this OMP B1 epitope on 31% of the clinical isolates tested. These data suggest that OMP B1 is a potential vaccine antigen against M. catarrhalis infections. ..
- Montini E, Held P, Noll M, Morcinek N, Al Dhalimy M, Finegold M, et al. In vivo correction of murine tyrosinemia type I by DNA-mediated transposition. Mol Ther. 2002;6:759-69 pubmed..Molecular analysis indicated that high-efficiency DNA-mediated transposition into the mouse genome was strictly dependent on the expression of wild-type transposase...
- Giguere S, Gaskin J, Miller C, Bowman J. Evaluation of a commercially available hyperimmune plasma product for prevention of naturally acquired pneumonia caused by Rhodococcus equi in foals. J Am Vet Med Assoc. 2002;220:59-63 pubmed..However, within this limited foal population, the difference in incidence of pneumonia caused by R equi observed between foals that received plasma and control foals was not significant. ..
- Gonzalez M, Erga K, Rivera J, Contreras L, Mladinich C, Schultz J, et al. Rate-dependent block in the sinus venosa of the swine heart during transverse right atrial activation: correlation between electrophysiologic and anatomic findings. J Cardiovasc Electrophysiol. 2005;16:193-200 pubmed..The sinus venosa and not the crista terminalis results in a rate-dependent line of block during transverse right atrial activation. The morphologic characteristics of the sinus venosa appear to facilitate block in this region. ..
- Fairbairn D. Allometry for sexual size dimorphism: testing two hypotheses for Rensch's rule in the water strider Aquarius remigis. Am Nat. 2005;166 Suppl 4:S69-84 pubmed..quot; While this hypothesis is unlikely to explain Rensch's rule among species or higher clades, it may explain widespread patterns of intraspecific variation in SSD recently documented for many insect species. ..
- Sengupta S, Kim K, Berk M, Oates R, Escobar P, Belinson J, et al. Lysophosphatidic acid downregulates tissue inhibitor of metalloproteinases, which are negatively involved in lysophosphatidic acid-induced cell invasion. Oncogene. 2007;26:2894-901 pubmed..LPA downregulates TIMP3, which may have targets other than metalloproteinases. Our in vivo metastasis mouse model is useful for studying the efficacy of therapeutic regimes of ovarian cancer. ..
- Zhao Y, Marotta M, Eichler E, Eng C, Tanaka H. Linkage disequilibrium between two high-frequency deletion polymorphisms: implications for association studies involving the glutathione-S transferase (GST) genes. PLoS Genet. 2009;5:e1000472 pubmed publisher..These results show a complex genomic organization and unexpected biological functions of CNVs within segmental duplications and emphasize the importance of detailed structural characterization for disease association studies. ..
- Hickey R, Lillegard J, Fisher J, McKenzie T, Hofherr S, Finegold M, et al. Efficient production of Fah-null heterozygote pigs by chimeric adeno-associated virus-mediated gene knockout and somatic cell nuclear transfer. Hepatology. 2011;54:1351-9 pubmed publisher..We expect that the subsequent generation of FAH-null homozygote pigs will serve as a significant advancement for translational research in the areas of metabolic liver disease, cirrhosis, and HCC. ..
- Robbins L, Nadeau J, Johnson K, Kelly M, Roselli Rehfuss L, Baack E, et al. Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. Cell. 1993;72:827-34 pubmed..The Eso-3J receptor is constitutively activated, while the Etob receptor remains hormone responsive and produces a greater activation of its effector, adenylyl cyclase, than does the wild-type allele. ..
- Croniger C, Trus M, Lysek Stupp K, Cohen H, Liu Y, Darlington G, et al. Role of the isoforms of CCAAT/enhancer-binding protein in the initiation of phosphoenolpyruvate carboxykinase (GTP) gene transcription at birth. J Biol Chem. 1997;272:26306-12 pubmed..We conclude that C/EBPalpha is required for the cAMP induction of PEPCK gene expression in the liver and that C/EBPbeta can compensate for the loss of C/EBPalpha if its concentration is induced to appropriate levels. ..
- Spring D, Krebs E. Deletion of 11 amino acids in p90(rsk-mo-1) abolishes kinase activity. Mol Cell Biol. 1999;19:317-20 pubmed..The findings provide additional support for the conclusion that the first catalytic domain of p90(rsk) is responsible for its enzymatic activity toward ribosomal protein S6. ..
- Roe A, Howard G, Blouin R, Snawder J. Characterization of cytochrome P450 and glutathione S-transferase activity and expression in male and female ob/ob mice. Int J Obes Relat Metab Disord. 1999;23:48-53 pubmed
- Evans G. Peripheral nerve injury: a review and approach to tissue engineered constructs. Anat Rec. 2001;263:396-404 pubmed..This impotency rate decreased to 24% when the nerves were left intact (Quinlan et al., J. Urol. 1991;145:380-383; J. Urol. 1991;145:998-1002). ..
- Meyer M, Shirley J, Titgemeyer E, Park A, Vanbaale M. Effect of mechanical processing and fat removal on the nutritive value of cottonseed for lactating dairy cows. J Dairy Sci. 2001;84:2503-14 pubmed..In situ ruminal degradation and in vitro ammonia N release indicate that processing of EEC was inadequate to protect the protein from ruminal degradation and EEC would not be a source of RUP. ..
- Turner C, Yang M, Lewis M. Environmental enrichment: effects on stereotyped behavior and regional neuronal metabolic activity. Brain Res. 2002;938:15-21 pubmed..These results suggest that, in a developmental model of spontaneous stereotypy, the enrichment-related prevention of stereotyped behavior is associated with increased CO activity. ..
- Gavrilin M, Mathes L, Podell M. Methamphetamine enhances cell-associated feline immunodeficiency virus replication in astrocytes. J Neurovirol. 2002;8:240-9 pubmed..Thus, lentiviral infection of the brain in the presence of the psychostimulant METH may result in enhanced astrocyte viral replication, producing a more rapid and increased brain viral load. ..
- Docherty D, Meteyer C, Wang J, Mao J, Case S, Chinchar V. Diagnostic and molecular evaluation of three iridovirus-associated salamander mortality events. J Wildl Dis. 2003;39:556-66 pubmed..Challenge assays are required to determine the fish and amphibian host range of these isolates and to assess the susceptibility of tiger and spotted salamanders to heterologous virus isolates...
- Michael McClain R, Wolz E, Davidovich A, Bausch J. Genetic toxicity studies with genistein. Food Chem Toxicol. 2006;44:42-55 pubmed..This observation is in agreement with published data on the inhibitory action of genistein on topoisomerase II, which is known to lead to chromosomal damage with a threshold dose response. ..
- Kreahling J, Graveley B. The iStem, a long-range RNA secondary structure element required for efficient exon inclusion in the Drosophila Dscam pre-mRNA. Mol Cell Biol. 2005;25:10251-60 pubmed..Thus, the iStem is a novel type of regulatory element that simultaneously controls the splicing of multiple alternative exons. ..
- D Orazio S, Shaw C, Starnbach M. H2-M3-restricted CD8+ T cells are not required for MHC class Ib-restricted immunity against Listeria monocytogenes. J Exp Med. 2006;203:383-91 pubmed..These data suggest that M3-restricted T cells are not required for protection against L. monocytogenes and underscore the importance of searching for new antigen-presenting molecules among the large MHC-Ib family of proteins. ..
- Aevermann B, Waters E. A comparative genomic analysis of the small heat shock proteins in Caenorhabditis elegans and briggsae. Genetica. 2008;133:307-19 pubmed..elegans and C. briggsae sHSPs. However, the evolutionary patterns do suggest that functional divergence has occurred between the sHSPs in C. elegans and C. briggsae and the sHSPs in more distantly related invertebrates. ..
- Liu C, Sarkaria J, Petell C, Paraskevakou G, Zollman P, Schroeder M, et al. Combination of measles virus virotherapy and radiation therapy has synergistic activity in the treatment of glioblastoma multiforme. Clin Cancer Res. 2007;13:7155-65 pubmed..This latter effect is mostly mediated via the extrinsic caspase-8 pathway, activated via increased signaling through the Fas death receptor pathway. These results could have translational implications in glioma therapy. ..
- Penton R, Quick M, Lester R. Short- and long-lasting consequences of in vivo nicotine treatment on hippocampal excitability. J Neurosci. 2011;31:2584-94 pubmed publisher..These mechanisms may contribute to hippocampal localized cue-motivated reinstatement of drug-seeking and/or cognitive deficits observed during withdrawal. ..
- Guidotti A, Grayson D. A neurochemical basis for an epigenetic vision of psychiatric disorders (1994-2009). Pharmacol Res. 2011;64:344-9 pubmed publisher..As you know, Dr. Costa was an eclectic scientist and in his 15 years of studies at UIC, he touched many other aspects of neuroscience research that are not discussed in this overview. ..
- Motiwala T, Zanesi N, Datta J, Roy S, Kutay H, Checovich A, et al. AP-1 elements and TCL1 protein regulate expression of the gene encoding protein tyrosine phosphatase PTPROt in leukemia. Blood. 2011;118:6132-40 pubmed publisher..Finally, using primary CLL cells we have shown an inverse relationship between TCL1 and PTPROt expression. These findings further substantiate the role of TCL1 in PTPROt suppression and its importance in the pathogenesis of CLL. ..
- Hengen K, Nelson N, Stang K, Johnson S, Crader S, Watters J, et al. Increased GABA(A) receptor ?-subunit expression on ventral respiratory column neurons protects breathing during pregnancy. PLoS ONE. 2012;7:e30608 pubmed publisher..Increased ? subunit expression may be critical to preserve respiratory function (and life) despite increased neurosteroid levels during pregnancy. ..
- Ni H, Boggess N, McGill M, Lebofsky M, Borude P, Apte U, et al. Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury. Toxicol Sci. 2012;127:438-50 pubmed publisher..Taken together, our data suggest that persistent activation of Nrf2 and increased hepatocyte proliferation protect against APAP-induced liver injury in Atg5 liver-specific knockout mice. ..
- Kistler W, Stallknecht D, DeLiberto T, Swafford S, Pedersen K, Van Why K, et al. Antibodies to avian influenza viruses in Canada geese (Branta canadensis): a potential surveillance tool?. J Wildl Dis. 2012;48:1097-101 pubmed publisher..Results indicate that Canada geese are frequently exposed to AIVs and, with resident populations, may potentially be useful as sentinels to confirm regional AIV transmission within wild bird populations. ..
- Glabinski A, Tuohy V, Ransohoff R. Expression of chemokines RANTES, MIP-1alpha and GRO-alpha correlates with inflammation in acute experimental autoimmune encephalomyelitis. Neuroimmunomodulation. 1998;5:166-71 pubmed..This consistent relationship supports the hypothesis that chemokines are relevant to leukocyte accumulation in CNS parenchyma. ..
- Regal J, Mohrman M, Sailstad D. Trimellitic anhydride-induced eosinophilia in a mouse model of occupational asthma. Toxicol Appl Pharmacol. 2001;175:234-42 pubmed..These studies are the first to demonstrate TMA-induced eosinophilia in mouse lung and to provide a model for comparing mechanisms and mediators responsible for the substantial eosinophilia induced by TMA and OA. ..
- Ralph Williams R, Lehmann Masten V, Otero Corchon V, Low M, Geyer M. Differential effects of direct and indirect dopamine agonists on prepulse inhibition: a study in D1 and D2 receptor knock-out mice. J Neurosci. 2002;22:9604-11 pubmed..These findings emphasize that further cross-species comparisons of the pharmacology of PPI are essential to understand the relevance of rodent PPI studies to the deficits in PPI observed in patients with schizophrenia. ..
- Miwa J, Freedman R, Lester H. Neural systems governed by nicotinic acetylcholine receptors: emerging hypotheses. Neuron. 2011;70:20-33 pubmed publisher..We also discuss how these contemporary advances can motivate attempts to exploit nicotinic systems therapeutically in Parkinson's disease, cognitive decline, epilepsy, and schizophrenia. ..
- Raffa K, Powell E, Townsend P. Temperature-driven range expansion of an irruptive insect heightened by weakly coevolved plant defenses. Proc Natl Acad Sci U S A. 2013;110:2193-8 pubmed publisher..Consequences extend from reduced food supplies for endangered grizzly bears to altered landscape and hydrological processes. ..
- Parr B, Parks A, Raff R. Promoter structure and protein sequence of msp130, a lipid-anchored sea urchin glycoprotein. J Biol Chem. 1990;265:1408-13 pubmed..The implications of the msp130 sequence for its possible functions are discussed...
- Grandy D, Marchionni M, Makam H, Stofko R, Alfano M, Frothingham L, et al. Cloning of the cDNA and gene for a human D2 dopamine receptor. Proc Natl Acad Sci U S A. 1989;86:9762-6 pubmed..The involvement of this sequence in alternative splicing and its biological significance are discussed. ..
- Jin P, Griffith L, Murphey R. Presynaptic calcium/calmodulin-dependent protein kinase II regulates habituation of a simple reflex in adult Drosophila. J Neurosci. 1998;18:8955-64 pubmed..These results suggest that basal CaMKII levels in the presynaptic neurons set the response level and dynamics of the entire neural circuit. ..
- Bruce S, Kaetzel C, Peterson M. Cryptic intron activation within the large exon of the mouse polymeric immunoglobulin receptor gene: cryptic splice sites correspond to protein domain boundaries. Nucleic Acids Res. 1999;27:3446-54 pubmed..The cryptic 5' splice site is located between protein subdomains where an intron is found in another gene of the immunoglobulin superfamily. ..
- Zhang Y, Denoya C, Skinner D, Fedechko R, McArthur H, Morgenstern M, et al. Genes encoding acyl-CoA dehydrogenase (AcdH) homologues from Streptomyces coelicolor and Streptomyces avermitilis provide insights into the metabolism of small branched-chain fatty acids and macrolide antibiotic production. Microbiology. 1999;145 ( Pt 9):2323-34 pubmed publisher..These results are consistent with the acdH gene encoding an acyl-CoA dehydrogenase with a broad substrate specificity that has a role in the catabolism of branched-chain amino acids in S. coelicolor and S. avermitilis...
- Chen N, Nomura M, She Q, Ma W, Bode A, Wang L, et al. Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice. Cancer Res. 2001;61:3908-12 pubmed..These data suggest that JNK2 is critical in the tumor promotion process. ..