Genomes and Genes
Experts and Doctors on animals in United Kingdom
Locale: United Kingdom
Publications1014 found, 100 shown here
- Perriton C, Powles N, Chiang C, Maconochie M, Cohn M. Sonic hedgehog signaling from the urethral epithelium controls external genital development. Dev Biol. 2002;247:26-46 pubmed
- Tsai C, Lin S, Ito M, Takagi N, Takada S, Ferguson Smith A. Genomic imprinting contributes to thyroid hormone metabolism in the mouse embryo. Curr Biol. 2002;12:1221-6 pubmed..These results demonstrate that disruption of the imprinting status of Dio3 results in abnormal thyroid hormone levels and may contribute to the phenotypic abnormalities in UPD12 mice and UPD14 humans. ..
- Rowe S, Allen L, Ridger V, Hellewell P, Whyte M. Caspase-1-deficient mice have delayed neutrophil apoptosis and a prolonged inflammatory response to lipopolysaccharide-induced acute lung injury. J Immunol. 2002;169:6401-7 pubmed..We conclude that caspase-1 modulates apoptosis of both peripheral blood and inflammatory neutrophils, but is not essential for IL-1beta production in the lung. ..
- Matthews J, Hodgkinson J, Dowdall S, Proudman C. Recent developments in research into the Cyathostominae and Anoplocephala perfoliata. Vet Res. 2004;35:371-81 pubmed..The steps involved in the development of this ELISA are described here. In addition to these recent advances in research, this review also outlines the principle areas for future research into these important equine parasites. ..
- Nakamura T, Ohbayashi M, Toda M, Hall D, Horgan C, Ono S. A specific CCR3 chemokine receptor antagonist inhibits both early and late phase allergic inflammation in the conjunctiva. Immunol Res. 2005;33:213-21 pubmed..These results constitute the first direct evidence that antagonism of CCR3 has clear potential for the treatment of allergic diseases. ..
- Kirby M, Smith A, Rooke J, Neall P, Scott A, Katsiadaki I. Ethoxyresorufin-O-deethylase (EROD) and vitellogenin (VTG) in flounder (Platichthys flesus): system interaction, crosstalk and implications for monitoring. Aquat Toxicol. 2007;81:233-44 pubmed..A greater understanding of system interaction and other factors, including genetics, that influence biomarker response to contaminants would be required to interpret biomarker monitoring data. ..
- Jennings M, Blankley R, Baron M, Golovanov A, Avis J. Specificity and autoregulation of Notch binding by tandem WW domains in suppressor of Deltex. J Biol Chem. 2007;282:29032-29042 pubmed publisher..The highly conserved tandem arrangement of WW domains in Nedd4 proteins, and similar arrangements in more diverse proteins, suggests domain-domain communication may be integral to regulation of their associated cellular activities. ..
- Zhang Y, Zhang M, Sears C, Emanuel K, Redwood C, El Armouche A, et al. Reduced phospholamban phosphorylation is associated with impaired relaxation in left ventricular myocytes from neuronal NO synthase-deficient mice. Circ Res. 2008;102:242-9 pubmed
- Prieur X, Tung Y, Griffin J, Farooqi I, O Rahilly S, Coll A. Leptin regulates peripheral lipid metabolism primarily through central effects on food intake. Endocrinology. 2008;149:5432-9 pubmed publisher..Whereas we cannot exclude direct peripheral effects of leptin on certain aspects of lipid metabolism, we were unable to detect any such effects on the parameters measured in this study. ..
- Guschina I, Harris K, Maskrey B, Goldberg B, Lloyd D, Harwood J. The microaerophilic flagellate, Trichomonas vaginalis, contains unusual acyl lipids but no detectable cardiolipin. J Eukaryot Microbiol. 2009;56:52-7 pubmed publisher..These data are discussed in relation to the organism's phylogenetic origin as a parasite showing secondary adaptation to microaerobic conditions...
- Humphries S. Filter feeders and plankton increase particle encounter rates through flow regime control. Proc Natl Acad Sci U S A. 2009;106:7882-7 pubmed publisher..Many ecological and industrial processes may be operating at substantially greater rates than currently assumed. ..
- Sobieszczuk D, Poliakov A, Xu Q, Wilkinson D. A feedback loop mediated by degradation of an inhibitor is required to initiate neuronal differentiation. Genes Dev. 2010;24:206-18 pubmed publisher..These findings reveal a feedback loop mediated by degradation of an inhibitor that is essential for progenitors to undergo the transition to neuronal differentiation. ..
- Fox N, White P, McClean C, Marion G, Evans A, Hutchings M. Predicting impacts of climate change on Fasciola hepatica risk. PLoS ONE. 2011;6:e16126 pubmed publisher..It can be used as a basis for indicating where active disease surveillance should be targeted and where the development of improved mitigation or adaptation measures is likely to bring the greatest benefits...
- Hewitson J, Ivens A, Harcus Y, Filbey K, McSorley H, Murray J, et al. Secretion of protective antigens by tissue-stage nematode larvae revealed by proteomic analysis and vaccination-induced sterile immunity. PLoS Pathog. 2013;9:e1003492 pubmed publisher..We have thus defined an extensive and novel repertoire of H. polygyrus proteins closely implicated in immune modulation and protective immunity. ..
- Zuniga E, Macal M, Lewis G, Harker J. Innate and Adaptive Immune Regulation During Chronic Viral Infections. Annu Rev Virol. 2015;2:573-97 pubmed publisher..In this review we discuss the common immunological hallmarks observed across a range of different persistently replicating viruses and host species, the underlying molecular mechanisms, and the biological and clinical implications. ..
- Hume C, Sabatier N, Menzies J. High-Sugar, but Not High-Fat, Food Activates Supraoptic Nucleus Neurons in the Male Rat. Endocrinology. 2017;158:2200-2211 pubmed publisher..Our data suggest that the presence of specific foods with different macronutrient profiles in the stomach differentially regulates the activity of oxytocin neurons. ..
- Gentle M. Cutaneous sensory afferents recorded from the nervus intramandibularis of Gallus gallus var domesticus. J Comp Physiol A. 1989;164:763-74 pubmed..Both units had fibres conducting in the 50 m/s range with thresholds in the 0.1 to 10 g range. The results are discussed in relation to the receptors found in other avian species and mammalian peripheral sensory afferents. ..
- Stitt A, McKenna D, Simpson D, Gardiner T, Harriott P, Archer D, et al. The 67-kd laminin receptor is preferentially expressed by proliferating retinal vessels in a murine model of ischemic retinopathy. Am J Pathol. 1998;152:1359-65 pubmed..The differential expression of 67LR between proliferating and quiescent retinal vessels suggests that this laminin receptor is an important and novel target for future chemotherapeutic intervention during proliferative vasculopathies. ..
- Green S, McKendrick M, Mohsen A, Schmid M, Prakasam S. Two simultaneous cases of Cyclospora cayatensis enteritis returning from the Dominican Republic. J Travel Med. 2000;7:41-2 pubmed
- Baker S, Spinks R, Jackson A, Lemon R. Synchronization in monkey motor cortex during a precision grip task. I. Task-dependent modulation in single-unit synchrony. J Neurophysiol. 2001;85:869-85 pubmed
- Hussain I, Christie G, Schneider K, Moore S, Dingwall C. Prodomain processing of Asp1 (BACE2) is autocatalytic. J Biol Chem. 2001;276:23322-8 pubmed..Interestingly, a proportion of mature Asp1 was expressed on the cell surface. When full-length Asp1(D110N) was expressed in COS-7 cells, it was not processed, suggesting that no other proteinase can activate Asp1 in these cells. ..
- Blogg S, Gennser M, Loveman G, Seddon F, Thacker J, White M. The effect of breathing hyperoxic gas during simulated submarine escape on venous gas emboli and decompression illness. Undersea Hyperb Med. 2003;30:163-74 pubmed..The rate of disappearance of VGE was significantly faster (p < 0.01) in the hyperoxic group. O2 toxicity was not discernible in any of the animals. ..
- Coutinho A, Borday C, Gilthorpe J, Jungbluth S, Champagnat J, Lumsden A, et al. Induction of a parafacial rhythm generator by rhombomere 3 in the chick embryo. J Neurosci. 2004;24:9383-90 pubmed..The r4 rhythm generator appears to be homologous to a murine respiratory parafacial neuronal system developing in r4 under the control of Krox20 and Hoxa1. These results identify a late role for Krox20 at the onset of neurogenesis. ..
- Gilbert J, Nfon C, Makepeace B, Njongmeta L, Hastings I, Pfarr K, et al. Antibiotic chemotherapy of onchocerciasis: in a bovine model, killing of adult parasites requires a sustained depletion of endosymbiotic bacteria (Wolbachia species). J Infect Dis. 2005;192:1483-93 pubmed..These results unequivocally demonstrate the macrofilaricidal potential of tetracyclines against Onchocerca infection and suggest that intermittent, protracted administration will be more effective than continuous shorter term treatment...
- Bennett M, Onnebo S, Azevedo C, Saiardi A. Inositol pyrophosphates: metabolism and signaling. Cell Mol Life Sci. 2006;63:552-64 pubmed..This review aims at summarising the recent progress of our knowledge of this exciting class of molecules, from inositol pyrophosphate discovery to the description of their physiological functions...
- Mihm M, Baker P, Ireland J, Smith G, Coussens P, Evans A, et al. Molecular evidence that growth of dominant follicles involves a reduction in follicle-stimulating hormone dependence and an increase in luteinizing hormone dependence in cattle. Biol Reprod. 2006;74:1051-9 pubmed..Results provide new molecular evidence for the hypothesis that DF experience a reduction in FSH dependence but acquire increased LH dependence as they grow during the low FSH milieu of follicular waves. ..
- Brook M, Tchen C, Santalucia T, McIlrath J, Arthur J, Saklatvala J, et al. Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signal-regulated kinase pathways. Mol Cell Biol. 2006;26:2408-18 pubmed..This effect is independent of kinases that are known to be synergistically activated by ERK and p38 MAPK. We present a model for the actions of TTP and the p38 MAPK pathway during distinct phases of the inflammatory response. ..
- Dickson J, Grabowska A, El Zaatari M, Atherton J, Watson S. Helicobacter pylori can induce heparin-binding epidermal growth factor expression via gastrin and its receptor. Cancer Res. 2006;66:7524-31 pubmed..In conclusion, gastrin and the CCK-2R play significant roles in the induction of HB-EGF gene and protein expression and ectodomain shedding by H. pylori. ..
- Chen F, Archambault V, Kar A, Lio P, D Avino P, Sinka R, et al. Multiple protein phosphatases are required for mitosis in Drosophila. Curr Biol. 2007;17:293-303 pubmed..Discovery of several novel cell-cycle PPs identifies a need for further studies of protein dephosphorylation. ..
- Sadek A, Magill P, Bolam J. A single-cell analysis of intrinsic connectivity in the rat globus pallidus. J Neurosci. 2007;27:6352-62 pubmed
- Bayele H, Peyssonnaux C, Giatromanolaki A, Arrais Silva W, Mohamed H, Collins H, et al. HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA forming microsatellite. Blood. 2007;110:3039-48 pubmed..This report also suggests that microsatellites may play critical roles in the directional evolution of complex heritable traits by regulating gene expression phenotypes. ..
- Kirton J, Crofts N, George S, Brennan K, Canfield A. Wnt/beta-catenin signaling stimulates chondrogenic and inhibits adipogenic differentiation of pericytes: potential relevance to vascular disease?. Circ Res. 2007;101:581-9 pubmed..This effect was negated by transduction of pericytes with RAd/dnTCF. Together, these results demonstrate that Wnt/beta-catenin signaling inhibits adipogenic and enhances chondrogenic differentiation of pericytes. ..
- German A, Harbour D, Helps C, Gruffydd Jones T. Is feline foamy virus really apathogenic?. Vet Immunol Immunopathol. 2008;123:114-8 pubmed publisher..Further investigation of the significance of these changes is warranted before FFV is developed as a vector for gene delivery. ..
- Jones P, Chase K, Martin A, Davern P, Ostrander E, Lark K. Single-nucleotide-polymorphism-based association mapping of dog stereotypes. Genetics. 2008;179:1033-44 pubmed publisher..The strengths and limitations of the approach are discussed as well as its potential to identify loci regulating the within-breed incidence of specific polygenic diseases. ..
- Sanderson D, Sprengel R, Seeburg P, Bannerman D. Deletion of the GluA1 AMPA receptor subunit alters the expression of short-term memory. Learn Mem. 2011;18:128-31 pubmed publisher..GluA1 knockout mice, however, showed greater suppression to a recent stimulus than to a nonrecent stimulus. Thus, GluA1 is not necessary for encoding, but affects the way that short-term memory is expressed. ..
- Hodson C, Cole A, Lewis L, Miles J, Purkiss A, Walden H. Structural analysis of human FANCL, the E3 ligase in the Fanconi anemia pathway. J Biol Chem. 2011;286:32628-37 pubmed publisher..In addition, we characterize the binding of human FANCL with its partners, Ube2t, FANCD2, and FANCI. Mutational analysis reveals which residues are required for substrate binding, and we also show the domain required for E2 binding. ..
- Weatherall K, Seutin V, Liégeois J, Marrion N. Crucial role of a shared extracellular loop in apamin sensitivity and maintenance of pore shape of small-conductance calcium-activated potassium (SK) channels. Proc Natl Acad Sci U S A. 2011;108:18494-9 pubmed publisher..This arrangement provides a unique binding site for each combination of SK subunits within a coassembled channel that may be targeted to produce blockers specific for heteromeric SK channels. ..
- Rutz C, St Clair J. The evolutionary origins and ecological context of tool use in New Caledonian crows. Behav Processes. 2012;89:153-65 pubmed publisher..However, it is clear from our analysis of existing work, and the development of some original ideas, that the unusual evolutionary trajectory of NC crows is probably the consequence of an intricate constellation of interplaying factors...
- Morelli M, Thébaud G, Chadœuf J, King D, Haydon D, Soubeyrand S. A Bayesian inference framework to reconstruct transmission trees using epidemiological and genetic data. PLoS Comput Biol. 2012;8:e1002768 pubmed publisher..Our method, while applied here in the context of FMDV, is general and with slight modification can be used in any situation where both spatiotemporal and genetic data are available. ..
- Jameson L, Taori S, Atkinson B, Levick P, Featherstone C, van der Burgt G, et al. Pet rats as a source of hantavirus in England and Wales, 2013. Euro Surveill. 2013;18: pubmed
- Skrzypiec A, Shah R, Schiavon E, Baker E, Skene N, Pawlak R, et al. Stress-induced lipocalin-2 controls dendritic spine formation and neuronal activity in the amygdala. PLoS ONE. 2013;8:e61046 pubmed publisher..Thus, amygdala-specific neuronal responses to Lcn-2 may represent a mechanism for behavioural adaptation to psychological stress. ..
- Cervellini I, Annenkov A, Brenton T, Chernajovsky Y, Ghezzi P, Mengozzi M. Erythropoietin (EPO) increases myelin gene expression in CG4 oligodendrocyte cells through the classical EPO receptor. Mol Med. 2013;19:223-9 pubmed publisher..In conclusion, EPO induces the expression of myelin genes in oligodendrocytes and this effect requires the presence of EPOR. This study demonstrates that EPOR can mediate neuroreparative effects. ..
- Lindström N, Hohenstein P, Davies J. Nephrons require Rho-kinase for proximal-distal polarity development. Sci Rep. 2013;3:2692 pubmed publisher..Our data demonstrate the importance of Rho-kinase in normal nephron tubulogenesis and patterning. ..
- Wastling J, Knight P, Ure J, Wright S, Thornton E, Scudamore C, et al. Histochemical and ultrastructural modification of mucosal mast cell granules in parasitized mice lacking the beta-chymase, mouse mast cell protease-1. Am J Pathol. 1998;153:491-504 pubmed..These data show that disruption of the mMCP-1 gene leads to profound histochemical and ultrastructural changes in IMMC granules. ..
- Hayward B, Moran V, Strain L, Bonthron D. Bidirectional imprinting of a single gene: GNAS1 encodes maternally, paternally, and biallelically derived proteins. Proc Natl Acad Sci U S A. 1998;95:15475-80 pubmed
- van der Merwe P. A subtle role for CD2 in T cell antigen recognition. J Exp Med. 1999;190:1371-4 pubmed
- Rellos P, Sygusch J, Cox T. Expression, purification, and characterization of natural mutants of human aldolase B. Role of quaternary structure in catalysis. J Biol Chem. 2000;275:1145-51 pubmed..Investigation of these two classes of mutant enzyme suggests that the integrity of the quaternary structure of aldolase B is critical for maintaining its full catalytic function. ..
- Klingenberg C. Morphometrics and the role of the phenotype in studies of the evolution of developmental mechanisms. Gene. 2002;287:3-10 pubmed..These methods complement the experimental approaches of developmental biology and genetics, and can be expected to be especially fruitful in combination with them. ..
- Mogensen M, Tucker J, Mackie J, Prescott A, Nathke I. The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly polarized epithelial cells. J Cell Biol. 2002;157:1041-8 pubmed
- McMahon L, Muriel J, Roberts B, Quinn M, Johnstone I. Two sets of interacting collagens form functionally distinct substructures within a Caenorhabditis elegans extracellular matrix. Mol Biol Cell. 2003;14:1366-78 pubmed..Consistent with this hypothesis, we find for the two identified interacting sets that the individual members of each set are temporally coexpressed, whereas the two sets are expressed approximately 2 h apart during matrix synthesis. ..
- Beaumont M. Estimation of population growth or decline in genetically monitored populations. Genetics. 2003;164:1139-60 pubmed..The method is used on three example data sets and problems in interpreting the posterior densities are highlighted and discussed...
- Reynolds L, de Bettignies C, Norton T, Beeser A, Chernoff J, Tybulewicz V. Vav1 transduces T cell receptor signals to the activation of the Ras/ERK pathway via LAT, Sos, and RasGRP1. J Biol Chem. 2004;279:18239-46 pubmed..We propose that reduced LAT phosphorylation is the key reason for defective TCR-induced calcium flux and ERK activation in Vav1-deficient cells. ..
- Kiss Toth E, Bagstaff S, Sung H, Jozsa V, Dempsey C, Caunt J, et al. Human tribbles, a protein family controlling mitogen-activated protein kinase cascades. J Biol Chem. 2004;279:42703-8 pubmed..These results suggest that Trbs control both the extent and the specificity of MAPK kinase activation of MAPK. ..
- Barran P, Roeske R, Pawson A, Sellar R, Bowers M, Morgan K, et al. Evolution of constrained gonadotropin-releasing hormone ligand conformation and receptor selectivity. J Biol Chem. 2005;280:38569-75 pubmed
- Harvey D. Analysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: An update covering the period 1999-2000. Mass Spectrom Rev. 2006;25:595-662 pubmed..Applications of MALDI mass spectrometry to the study of enzymes acting on carbohydrates (glycosyltransferases and glycosidases) and to the synthesis of carbohydrates, are also covered. ..
- Barcaroli D, Bongiorno Borbone L, Terrinoni A, Hofmann T, Rossi M, Knight R, et al. FLASH is required for histone transcription and S-phase progression. Proc Natl Acad Sci U S A. 2006;103:14808-12 pubmed..These results identify FLASH as an important component of the machinery required for histone precursor mRNA expression and cell-cycle progression. ..
- Mitchell A, Gaffan D. The magnocellular mediodorsal thalamus is necessary for memory acquisition, but not retrieval. J Neurosci. 2008;28:258-63 pubmed publisher..Thus, MDmc is required for new learning of scene discriminations but not for their retention and retrieval. This finding is the first evidence that MDmc plays a specific role in memory acquisition. ..
- Fernandes M, Brosens J, Gellersen B. Honey, we need to talk about the membrane progestin receptors. Steroids. 2008;73:942-52 pubmed publisher..While the reason for these startling opposing results remains unclear, a critical review of existing data may help to shed some light onto the controversial mPRs. Time has come to talk. ..
- Trickey M, Grimaldi M, Yamano H. The anaphase-promoting complex/cyclosome controls repair and recombination by ubiquitylating Rhp54 in fission yeast. Mol Cell Biol. 2008;28:3905-16 pubmed publisher..We thus propose that it is critical to control levels of Rhp54 in G1 to suppress HR repair of double-strand breaks and during meiosis to coordinate interhomolog recombination. ..
- Thomson N, Clayton D, Windhorst D, Vernikos G, Davidson S, Churcher C, et al. Comparative genome analysis of Salmonella Enteritidis PT4 and Salmonella Gallinarum 287/91 provides insights into evolutionary and host adaptation pathways. Genome Res. 2008;18:1624-37 pubmed publisher..Enteritidis-harboring mutations in functional homologs of the pseudogenes present in S. Gallinarum could provide an experimentally tractable route toward unraveling the genetic basis of host adaptation in S. enterica...
- Rodgers J. Human African trypanosomiasis, chemotherapy and CNS disease. J Neuroimmunol. 2009;211:16-22 pubmed publisher..This review summarises the clinical manifestations of the infection and chemotherapeutic regimens as well as the current research findings and hypotheses regarding the neuropathogenesis of the disease. ..
- Patterson M, Murphy K, Patel S, Patel N, Greenwood H, Cooke J, et al. Hypothalamic injection of oxyntomodulin suppresses circulating ghrelin-like immunoreactivity. Endocrinology. 2009;150:3513-20 pubmed publisher..Postprandial release of anorexic gut hormones may thus act centrally to contribute to the postprandial reduction in circulating ghrelin. ..
- Meng J, Adkin C, Arechavala Gomeza V, Boldrin L, Muntoni F, Morgan J. The contribution of human synovial stem cells to skeletal muscle regeneration. Neuromuscul Disord. 2010;20:6-15 pubmed publisher..Therefore, despite their limited capacity to regenerate skeletal muscle, hSSCs could play a role in treating muscular dystrophies secondary to defects in extracellular matrix proteins. ..
- Faux C, Rakic S, Andrews W, Yanagawa Y, Obata K, Parnavelas J. Differential gene expression in migrating cortical interneurons during mouse forebrain development. J Comp Neurol. 2010;518:1232-48 pubmed publisher..These data therefore provide a framework for future studies aimed at elucidating the complexities of interneuron migration and, in turn, may reveal important genes that are related to the development of specific neurological disorders. ..
- Chevin L, Lande R, Mace G. Adaptation, plasticity, and extinction in a changing environment: towards a predictive theory. PLoS Biol. 2010;8:e1000357 pubmed publisher..We use environmental tolerance curves and other examples of ecological and evolutionary responses to climate change to illustrate how these mechanistic approaches can be developed for predictive purposes. ..
- Schornack S, Van Damme M, Bozkurt T, Cano L, Smoker M, Thines M, et al. Ancient class of translocated oomycete effectors targets the host nucleus. Proc Natl Acad Sci U S A. 2010;107:17421-6 pubmed publisher..Finally, this work further implicates the host nucleus as an important cellular compartment where the fate of plant-microbe interactions is determined...
- Lawson C, Donald S, Anderson K, Patton D, Welch H. P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses. J Immunol. 2011;186:1467-76 pubmed publisher..We conclude that P-Rex1 and Vav1 together are the major fMLFR-dependent Dbl family Rac-GEFs in neutrophils and cooperate in the control of fMLF-stimulated neutrophil responses. ..
- Feng J, Mantesso A, De Bari C, Nishiyama A, Sharpe P. Dual origin of mesenchymal stem cells contributing to organ growth and repair. Proc Natl Acad Sci U S A. 2011;108:6503-8 pubmed publisher..This study identifies a dual origin of MSCs in a single tissue and suggests that the pericyte contribution to MSC-derived mesenchymal cells in any given tissue is variable and possibly dependent on the extent of the vascularity...
- Holland J, Bandelow S, Hogervorst E. Testosterone levels and cognition in elderly men: a review. Maturitas. 2011;69:322-37 pubmed publisher..Larger randomised, controlled trials are needed to further investigate testosterone treatment in protecting against cognitive decline and/or dementia. ..
- Scott H, Howarth J, Lee Y, Wong L, Bantounas I, Phylactou L, et al. MiR-3120 is a mirror microRNA that targets heat shock cognate protein 70 and auxilin messenger RNAs and regulates clathrin vesicle uncoating. J Biol Chem. 2012;287:14726-33 pubmed publisher..Finally, mirror miRNAs are likely to represent a new group of miRNAs with complex roles in coordinating gene expression. ..
- Byth K, Conroy L, Howlett S, Smith A, May J, Alexander D, et al. CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation. J Exp Med. 1996;183:1707-18 pubmed..We conclude that CD45 is not required at any stage during the generation of mature peripheral B cells, however its loss reveals a previously unrecognized role for CD45 in the regulation of certain subpopulations of B cells. ..
- Bogdanov Y, Dale L, King B, Whittock N, Burnstock G. Early expression of a novel nucleotide receptor in the neural plate of Xenopus embryos. J Biol Chem. 1997;272:12583-90 pubmed..This restricted pattern of expression and novel pharmacological features confer unique properties to XlP2Y, which may play a key role in the early development of neural tissue. ..
- O Connor R, Jenson J, Devaney E. NO contributes to proliferative suppression in a murine model of filariasis. Infect Immun. 2000;68:6101-7 pubmed
- Esposti M, Erler J, Hickman J, Dive C. Bid, a widely expressed proapoptotic protein of the Bcl-2 family, displays lipid transfer activity. Mol Cell Biol. 2001;21:7268-76 pubmed..Thus, Bid is likely to be involved in the transport and recycling of mitochondrial phospholipids. We discuss how this new role of Bid may relate to its proapoptotic action. ..
- Waterfield N, Dowling A, Sharma S, Daborn P, Potter U, ffrench Constant R. Oral toxicity of Photorhabdus luminescens W14 toxin complexes in Escherichia coli. Appl Environ Microbiol. 2001;67:5017-24 pubmed..The implications for the potential mode of action of the toxin complex genes are discussed. ..
- Roberts R. Clinical practice. Head lice. N Engl J Med. 2002;346:1645-50 pubmed
- Morgan K, Conklin D, Pawson A, Sellar R, Ott T, Millar R. A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12. Endocrinology. 2003;144:423-36 pubmed..A stem-loop motif resembling a selenocysteine insertion sequence and a potential alternative translation initiation site might enable expression of further proteins involved in interactions within the GnRH system. ..
- Young M, Tanner M. Distinct regions of human glycophorin A enhance human red cell anion exchanger (band 3; AE1) transport function and surface trafficking. J Biol Chem. 2003;278:32954-61 pubmed
- Springbett A, MacKenzie K, Woolliams J, Bishop S. The contribution of genetic diversity to the spread of infectious diseases in livestock populations. Genetics. 2003;165:1465-74 pubmed..In summary, more heterogeneous populations are not expected to suffer fewer epidemics on average, but are less likely to suffer catastrophic epidemics. ..
- Anderson L, Rossi D, Linehan J, Brandner S, Weissmann C. Transgene-driven expression of the Doppel protein in Purkinje cells causes Purkinje cell degeneration and motor impairment. Proc Natl Acad Sci U S A. 2004;101:3644-9 pubmed..A similar situation was reported for the corresponding TgL7-DeltaPrP mice supporting the concept that Dpl and DeltaPrP cause cell death, possibly by interfering with a common signaling cascade essential for cell survival. ..
- Allen N, Rossi D, Attwell D. Sequential release of GABA by exocytosis and reversed uptake leads to neuronal swelling in simulated ischemia of hippocampal slices. J Neurosci. 2004;24:3837-49 pubmed..These data show that ischemia releases GABA initially by exocytosis and then by reversal of GAT-1 transporters and that the resulting Cl- influx through GABA(A) receptor channels causes potentially neurotoxic cell swelling. ..
- Bond M, Sala Newby G, Newby A. Focal adhesion kinase (FAK)-dependent regulation of S-phase kinase-associated protein-2 (Skp-2) stability. A novel mechanism regulating smooth muscle cell proliferation. J Biol Chem. 2004;279:37304-10 pubmed..Taken together, these data demonstrate that the vascular ECM controls SMC proliferation via FAK-dependent regulation of Skp-2 protein stability. ..
- Garnett M, Marais R. Guilty as charged: B-RAF is a human oncogene. Cancer Cell. 2004;6:313-9 pubmed..Here we review the rapid progress made in our understanding of B-RAF as an oncogene and of its role in cancer. ..
- MacAulay K, Blair A, Hajduch E, Terashima T, Baba O, Sutherland C, et al. Constitutive activation of GSK3 down-regulates glycogen synthase abundance and glycogen deposition in rat skeletal muscle cells. J Biol Chem. 2005;280:9509-18 pubmed