Experts and Doctors on animals in Japan


Locale: Japan
Topic: animals

Top Publications

  1. Nakayama K, Nishimaru H, Kudo N. Developmental changes in 5-hydroxytryptamine-induced rhythmic activity in the spinal cord of rat fetuses in vitro. Neurosci Lett. 2001;307:1-4 pubmed
    ..These results indicate that, at and shortly after its onset, the rhythmic activity is driven mainly by glycinergic rather than glutamatergic excitatory synaptic inputs, but that the latter become dominant later on. ..
  2. Sugi T, Morikawa K, Jingami H. [Metabotropic glutamate receptor trafficking mechanism--autoinhibitory role of a scaffold protein tamalin]. Seikagaku. 2008;80:416-20 pubmed
  3. Kamata R, Shiraishi F, Nakajima D, Takahashi S, Shimizu A. Evaluation of the impact of in-ovo exposure to dicofol on avian reproduction. Environ Toxicol Chem. 2010;29:2316-22 pubmed publisher
    ..The results indicate that transovarian exposure, especially to o,p'-dicofol, could damage avian reproduction mainly through eggshell thinning. ..
  4. Wakamatsu K, Ito S, Fujita K. Melanin-related metabolites in urine of B16 melanoma-bearing mice. Acta Derm Venereol. 1988;68:385-9 pubmed
    ..However, 5H6MI2C had a higher excretion level at the early stage of melanoma progression, while 5-S-CD had a higher excretion level at the later stage...
  5. Itoh Y, Kimura C, Onda H, Fujino M. Canine endothelin-2: cDNA sequence for the mature peptide. Nucleic Acids Res. 1989;17:5389 pubmed
  6. Tsujimura A, Yasojima K, Kuboki Y, Suzuki A, Ueno N, Shiokawa K, et al. Developmental and differential regulations in gene expression of Xenopus pleiotrophic factors-alpha and -beta. Biochem Biophys Res Commun. 1995;214:432-9 pubmed
    ..laevis. ..
  7. Mori S, Goto K, Goto F, Murakami K, Ohkawara S, Yoshinaga M. Dynamic changes in mRNA expression of neutrophils during the course of acute inflammation in rabbits. Int Immunol. 1994;6:149-56 pubmed
    ..Pattern 3 mRNAs of ferritin L and H chain were induced slowly, and increased with progression of the inflammatory process.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  8. Makino Y, Yogosawa S, Kanemaki M, Yoshida T, Yamano K, Kishimoto T, et al. Structures of the rat proteasomal ATPases: determination of highly conserved structural motifs and rules for their spacing. Biochem Biophys Res Commun. 1996;220:1049-54 pubmed
    ..The spacing between individual motifs was strictly conserved in the rat ATPases. These findings suggest a common function of the rat proteasomal ATPases in ATP-dependent RNA/DNA unwinding. ..
  9. Nonomura A, Kono N, Mizukami Y, Nakanuma Y. Histological changes of the liver in experimental graft-versus-host disease across minor histocompatibility barriers. VIII. Role of eosinophil infiltration. Liver. 1996;16:42-7 pubmed
    ..These results indicate that not only lymphocytes but also eosinophils may be involved in the production of the bile duct injury in hepatic graft-versus-host disease, especially in its early chronic stage. ..

More Information

Publications1194 found, 100 shown here

  1. Takano M, Kondo J, Yayama K, Otani M, Sano K, Okamoto H. Molecular cloning of cDNAs for mouse low-molecular-weight and high-molecular-weight prekininogens. Biochim Biophys Acta. 1997;1352:222-30 pubmed
    ..A genomic Southern blot using H-prekininogen cDNA revealed that the L- and H-prekininogen mRNAs in mouse are probably encoded by a single gene, as is the case in both human and bovine. ..
  2. Yanagihara I, Yamagata M, Sakai N, Shukunami C, Kurahashi H, Yamazaki M, et al. Genomic organization of the human chondromodulin-1 gene containing a promoter region that confers the expression of reporter gene in chondrogenic ATDC5 cells. J Bone Miner Res. 2000;15:421-9 pubmed
    ..These results suggest that the element -446/+87 confers the cartilage-specific expression of this gene by some factor(s) other than Sox9, Og12, and Cart-1. ..
  3. Moriyasu Y, Ishikawa K, Kikuchi A, Imanishi S, Tomita S, Akutsu K, et al. Sequence analysis of Pns11, a nonstructural protein of rice gall dwarf virus, and its expression and detection in infected rice plants and vector insects. Virus Genes. 2000;20:237-41 pubmed
    ..However, the antiserum did not react with purified viral proteins. These results suggest that S11 encodes a nonstructural protein of RGDV. This protein was named Pns11. ..
  4. Terawaki S, Maesaki R, Okada K, Hakoshima T. Crystallographic characterization of the radixin FERM domain bound to the C-terminal region of the human Na+/H+-exchanger regulatory factor (NHERF). Acta Crystallogr D Biol Crystallogr. 2003;59:177-9 pubmed
    ..38 (2), b = 146.27 (4), c = 177.76 (7) A. The crystal contains four complexes in the asymmetric unit. An intensity data set was collected to a resolution of 2.50 A. ..
  5. Miyazaki K, Tomii R, Kurome M, Ueda H, Hirakawa K, Ueno S, et al. Evaluation of the quality of porcine somatic cell nuclear transfer embryo by gene transcription profiles. J Reprod Dev. 2005;51:123-31 pubmed
    ..Our study suggests that expression profiles of FGFr72IIIb, IL6ralpha, and Xist can be used as markers for the diagnosis of the developmental potency of porcine nuclear transfer embryos...
  6. Kyo F, Futani H, Matsui K, Terada M, Adachi K, Nagata K, et al. Endogenous interleukin-6, but not tumor necrosis factor alpha, contributes to the development of toll-like receptor 4/myeloid differentiation factor 88-mediated acute arthritis in mice. Arthritis Rheum. 2005;52:2530-40 pubmed
    ..LPS-induced IL-6, in the absence of TNFalpha, mediates LPS-induced arthritis. These results suggest that IL-6 is a rational target for therapeutic regimens for inflammatory arthritis, including ReA and rheumatoid arthritis. ..
  7. Togawa K, Moritani M, Yaguchi H, Itakura M. Multidimensional genome scans identify the combinations of genetic loci linked to diabetes-related phenotypes in mice. Hum Mol Genet. 2006;15:113-28 pubmed
  8. Higo N, Oishi T, Yamashita A, Murata Y, Matsuda K, Hayashi M. Northern blot and in situ hybridization analyses for the neurogranin mRNA in the developing monkey cerebral cortex. Brain Res. 2006;1078:35-48 pubmed
    ..The transiently increased expression of neurogranin in the postnatal neocortex may be a molecular basis for the postsynaptic modification of afferent inputs possibly from subcortical structures. ..
  9. Iemitsu M, Maeda S, Jesmin S, Otsuki T, Miyauchi T. Exercise training improves aging-induced downregulation of VEGF angiogenic signaling cascade in hearts. Am J Physiol Heart Circ Physiol. 2006;291:H1290-8 pubmed
    ..These findings suggest that exercise training improves aging-induced downregulation of cardiac VEGF angiogenic signaling cascade, thereby contributing to the exercise training-induced improvement of angiogenesis in old age. ..
  10. Somfai T, Ozawa M, Noguchi J, Kaneko H, Ohnuma K, Karja N, et al. Diploid porcine parthenotes produced by inhibition of first polar body extrusion during in vitro maturation of follicular oocytes. Reproduction. 2006;132:559-70 pubmed
    ..0%) was similar to that in diploid parthenotes. These results suggest that the proportion of homozygous and heterozygous genes does not affect in vitro embryo development to the blastocyst stage. ..
  11. Takemori H, Kanematsu M, Kajimura J, Hatano O, Katoh Y, Lin X, et al. Dephosphorylation of TORC initiates expression of the StAR gene. Mol Cell Endocrinol. 2007;265-266:196-204 pubmed
    ..Our experiments using KG501, a disruptor of the interaction between phospho-CREB and CBP/p300, also support the importance of TORC in the regulation of StAR gene expression. ..
  12. Nisijima K, Shioda K, Iwamura T. Neuroleptic malignant syndrome and serotonin syndrome. Prog Brain Res. 2007;162:81-104 pubmed
    ..In this review we describe the historical background, clinical manifestations, diagnosis, and differential diagnosis of these two syndromes based on our observations on the experimental and clinical data. ..
  13. Kato K, Kikuchi S, Konno S, Sekiguchi M. Participation of 5-hydroxytryptamine in pain-related behavior induced by nucleus pulposus applied on the nerve root in rats. Spine (Phila Pa 1976). 2008;33:1330-6 pubmed publisher
    ..These results suggest that 5-HT plays a role in the early phase of the chemical pathogenesis of sciatica in LDH in rats. ..
  14. Yamauchi M, Kawai S, Kato T, Ooshima T, Amano A. Odd-skipped related 1 gene expression is regulated by Runx2 and Ikzf1 transcription factors. Gene. 2008;426:81-90 pubmed publisher
    ..These findings indicate that Osr1 expression is regulated by Runx2 and Ikzf1, which are known as master-gene of osteogenesis and hematopoiesis, respectively. ..
  15. Fujita T, Kishimoto A, Shiba H, Hayashida K, Kajiya M, Uchida Y, et al. Irsogladine maleate regulates neutrophil migration and E-cadherin expression in gingival epithelium stimulated by Aggregatibacter actinomycetemcomitans. Biochem Pharmacol. 2010;79:1496-505 pubmed publisher
    ..actinomycetemcomitans. In conclusion, IM may control A. actinomycetemcomitans-induced gingival inflammation by regulating neutrophil migration and E-cadherin expression in gingival epithelium...
  16. Furuta M, Fukushima A, Chiba S, Sano A, Akema T, Kimura F, et al. Progesterone receptor immunoreactivity in the brains of ovariectomized aged rats. Neuroreport. 2010;21:777-81 pubmed publisher
    ..Therefore, the ability of estrogen to induce PR immunoreactivity in the hypothalamus in ovariectomized rats is attenuated in old rats compared with young rats. ..
  17. Yamasaki C, Kataoka M, Kato Y, Kakuni M, Usuda S, Ohzone Y, et al. In vitro evaluation of cytochrome P450 and glucuronidation activities in hepatocytes isolated from liver-humanized mice. Drug Metab Pharmacokinet. 2010;25:539-50 pubmed
    ..We conclude that chimeric mice may be a useful tool for supplying fresh h-hepatocytes on demand that provide high and stable phase I enzyme and glucuronidation activities. ..
  18. Koshi K, Ushizawa K, Kizaki K, Takahashi T, Hashizume K. Expression of endogenous retrovirus-like transcripts in bovine trophoblastic cells. Placenta. 2011;32:493-9 pubmed publisher
    ..This is the first evidence that endogenous retrovirus envelope element genes are expressed in bovine binucleate cells. ..
  19. Morimoto Y, Hirohashi M, Ogami A, Oyabu T, Myojo T, Hashiba M, et al. Pulmonary toxicity following an intratracheal instillation of nickel oxide nanoparticle agglomerates. J Occup Health. 2011;53:293-5 pubmed
    ..The CINC-2αβ concentration was elevated from 3 days to 6 mo in the lung tissue. These results showed that micron-sized nickel oxide nanoparticle agglomerates also induced a persistent inflammatory response. ..
  20. Shinohara H, Behar M, Inoue K, Hiroshima M, Yasuda T, Nagashima T, et al. Positive feedback within a kinase signaling complex functions as a switch mechanism for NF-?B activation. Science. 2014;344:760-4 pubmed publisher
  21. Lee H, Fujimoto M, Ohkawara T, Honda H, Serada S, Terada Y, et al. Leucine rich α-2 glycoprotein is a potential urinary biomarker for renal tubular injury. Biochem Biophys Res Commun. 2018;498:1045-1051 pubmed publisher
    ..These results suggest that urinary LRG could be applied to a biomarker detecting renal tubular injury in various renal diseases. ..
  22. Hori N, Murakawa K, Matoba R, Fukushima A, Okubo K, Matsubara K. A new human ribosomal protein sequence, homologue of rat L9. Nucleic Acids Res. 1993;21:4395 pubmed
  23. Sakamoto S, Hirai H, Taga H, Uchikoshi T, Sunaga T, Endo Y, et al. Inhibition by 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil of hepatocarcinogenesis induced by 3'-methyl-4-dimethylaminoazobenzene in rats. Anticancer Res. 1991;11:561-6 pubmed
    ..These results indicate that the suppression of de novo synthesis in pyrimidine metabolism prevents hepatocarcinogenesis...
  24. Tai T, Kawashima I, Furukawa K, Lloyd K. Monoclonal antibody R24 distinguishes between different N-acetyl- and N-glycolylneuraminic acid derivatives of ganglioside GD3. Arch Biochem Biophys. 1988;260:51-5 pubmed
    ..These findings suggest that the epitope detected by MAb R24 is the trisaccharide structure NeuAc alpha 2----8Sia alpha 2----3Gal-, which must be in a terminal position. ..
  25. Kadowaki K, Matsuno H, Tsuji H, Tunru I. CD4+ T cells from collagen-induced arthritic mice are essential to transfer arthritis into severe combined immunodeficient mice. Clin Exp Immunol. 1994;97:212-8 pubmed
    ..It is probable that memory CD4+ T cells stimulate production of antibodies to CII and subsequent arthritis. This study clarifies the role of T lymphocytes in the transfer of CIA to SCID mice. ..
  26. Ogata M, Sawada M, Kosugi A, Hamaoka T. Developmentally regulated expression of a murine receptor-type protein tyrosine phosphatase in the thymus. J Immunol. 1994;153:4478-87 pubmed
    ..No upregulation of mRPTP-sigma was observed in the spleen cells stimulated with Con A. Developmental regulation of mRPTP-sigma expression suggests its involvement in the control of T lymphocyte differentiation. ..
  27. Yoshida T, Yamanaka K, Atsumi S, Tsumura H, Sasaki R, Tomita K, et al. A novel hypothyroid 'growth-retarded' mouse derived from Snell's dwarf mouse. J Endocrinol. 1994;142:435-46 pubmed
  28. Kondo F, Hamada E, Tsai C, Lin S, Tateyama S, Saitanu K. A reverse-phase high-performance liquid chromatographic determination of nicarbazin residues in eggs. Cytobios. 1993;76:175-82 pubmed
    ..005 micrograms/ml. Nicarbazin was detected in 10% of eggs obtained by feeding chickens with a diet contaminated with nicarbazin within the range 0.07 to 1.39 micrograms/g, but it was not detected in eggs obtained commercially...
  29. Matsutani A, Takeuchi Y, Ishihara H, Kuwano S, Oka Y. Molecular cloning of human mitochondrial glycerophosphate dehydrogenase gene: genomic structure, chromosomal localization, and existence of a pseudogene. Biochem Biophys Res Commun. 1996;223:481-6 pubmed
    ..Genomic cloning also identified a pseudogene located on chromosome 19q13.4. These results provide information useful for analyzing the mGPDH gene in patients with non-insulin dependent diabetes mellitus. ..
  30. Imamura Y, Kaneko M, Mori Y, Otagiri M. Sex-dependent pharmacokinetics and in vitro reductive metabolism of acetohexamide in Wistar-Imamichi rats. Biol Pharm Bull. 1999;22:435-8 pubmed
    ..Based on these results, it is reasonable to assume that the sex-dependent pharmacokinetics of acetohexamide observed in Wistar-IM rats is associated with the male-specific hydroxylation catalyzed by CYP2C11. ..
  31. Yoshioka M, Tanaka K, Miyazaki I, Fujita N, Higashi Y, Asanuma M, et al. The dopamine agonist cabergoline provides neuroprotection by activation of the glutathione system and scavenging free radicals. Neurosci Res. 2002;43:259-67 pubmed
  32. Shoji H, Nishi N, Hirashima M, Nakamura T. Characterization of the Xenopus galectin family. Three structurally different types as in mammals and regulated expression during embryogenesis. J Biol Chem. 2003;278:12285-93 pubmed
    ..These results show that the expression of each member is spatiotemporally regulated from eggs to adulthood, suggesting that galectins play multiple roles not only in adults, but also in development. ..
  33. Goto K, Honda M, Kobayashi T, Uehara K, Kojima A, Akema T, et al. Heat stress facilitates the recovery of atrophied soleus muscle in rat. Jpn J Physiol. 2004;54:285-93 pubmed
    ..The data also indicated that the combination of heat and mechanical stress evoked larger and long lasting HSP72 response than does heat or mechanical stress alone. ..
  34. Uemura T, Kawasaki T, Taniguchi M, Moritani Y, Hayashi K, Saito T, et al. Biological properties of a specific Galpha q/11 inhibitor, YM-254890, on platelet functions and thrombus formation under high-shear stress. Br J Pharmacol. 2006;148:61-9 pubmed
    ..9 YM-254890 is a useful tool for investigating Galpha(q/11)-coupled receptor signaling and the physiological roles of Galpha(q/11). ..
  35. Katsura M, Shibasaki M, Hayashida S, Torigoe F, Tsujimura A, Ohkuma S. Increase in expression of alpha1 and alpha2/delta1 subunits of L-type high voltage-gated calcium channels after sustained ethanol exposure in cerebral cortical neurons. J Pharmacol Sci. 2006;102:221-30 pubmed
  36. Fujii H, Honoki K, Tsujiuchi T, Kido A, Yoshitani K, Mori T, et al. Reduced expression of INK4a/ARF genes in stem-like sphere cells from rat sarcomas. Biochem Biophys Res Commun. 2007;362:773-8 pubmed
  37. Kawabata A, Matsunami M, Sekiguchi F. Gastrointestinal roles for proteinase-activated receptors in health and disease. Br J Pharmacol. 2008;153 Suppl 1:S230-40 pubmed
    ..There is also fundamental and clinical evidence for involvement of PAR2 in colonic pain. PARs are thus considered key molecules in regulation of GI functions and targets for development of drugs for treatment of various GI diseases. ..
  38. Mutsuzaki H, Ito A, Sakane M, Sogo Y, Oyane A, Ochiai N. Fibroblast growth factor-2-apatite composite layers on titanium screw to reduce pin tract infection rate. J Biomed Mater Res B Appl Biomater. 2008;86:365-74 pubmed publisher
    ..056 Nm and 93.8% for those without the composite layer. Therefore, titanium screws with the FGF-2-apatite composite layer are useful for improving bone-screw interface strength and infection resistance in external skeletal fixation. ..
  39. Okabayashi S, Kimura N. Leucine-rich glioma inactivated 3 is involved in amyloid beta peptide uptake by astrocytes and endocytosis itself. Neuroreport. 2008;19:1175-9 pubmed publisher
    ..Together with our earlier findings, our results suggest that LGI3 is involved in Abeta uptake by astrocytes and even endocytosis itself. ..
  40. Furukawa A, Uchida K, Ishige Y, Ishige I, Kobayashi I, Takemura T, et al. Characterization of Propionibacterium acnes isolates from sarcoid and non-sarcoid tissues with special reference to cell invasiveness, serotype, and trigger factor gene polymorphism. Microb Pathog. 2009;46:80-7 pubmed publisher
    ..acnes to sarcoidosis, the present study clarified the cell invasiveness of P. acnes and the close correlation of cell invasiveness to the serotype and genotype of the two invasion-associated P. acnes genes. ..
  41. Shiomi K. Novel peptide toxins recently isolated from sea anemones. Toxicon. 2009;54:1112-8 pubmed publisher
    ..This review deals with the structural and functional features of these recently isolated sea anemone peptide toxins that are promising tools in studying the physiology of diverse ion channels...
  42. Abouelenien F, Nakashimada Y, Nishio N. Dry mesophilic fermentation of chicken manure for production of methane by repeated batch culture. J Biosci Bioeng. 2009;107:293-5 pubmed publisher
    ..This clearly demonstrates that spontaneous acclimation of the methanogenic consortia to high levels of ammonia could occur and result in production of methane even under a high percentage of total solid (25%) and a high level of ammonia...
  43. Senzaki K, Ozaki S, Yoshikawa M, Ito Y, Shiga T. Runx3 is required for the specification of TrkC-expressing mechanoreceptive trigeminal ganglion neurons. Mol Cell Neurosci. 2010;43:296-307 pubmed publisher
    ..These findings suggest that Runx3 is required for the specification of TrkC-expressing TG neurons, conveying mechanoreceptive signals from the Merkel cells in the ORS of the whisker vibrissae to the Sp5I. ..
  44. Konno K. Plant latex and other exudates as plant defense systems: roles of various defense chemicals and proteins contained therein. Phytochemistry. 2011;72:1510-30 pubmed publisher
  45. Katsu K, Tokumori D, Tatsumi N, Suzuki A, Yokouchi Y. BMP inhibition by DAN in Hensen's node is a critical step for the establishment of left-right asymmetry in the chick embryo. Dev Biol. 2012;363:15-26 pubmed publisher
    ..Our data indicate that Dan plays an essential role in the establishment of the L-R axis by inhibiting BMP signaling around the node...
  46. Aoki H, Sugihara I. Morphology of single olivocerebellar axons in the denervation-reinnervation model produced by subtotal lesion of the rat inferior olive. Brain Res. 2012;1449:24-37 pubmed publisher
    ..The results suggest that the capacity of surviving axons to reinnervate is dependent on targets and possibly limited by neuronal metabolism and axonal flow. ..
  47. Ushida H, Chano T, Minami K, Kita H, Kawakami T, Okabe H, et al. Therapeutic potential of SOX2 inhibition for embryonal carcinoma. J Urol. 2012;187:1876-81 pubmed publisher
    ..This study shows the therapeutic potential of SOX2 silencing for embryonal carcinoma. However, further improvements are needed in SOX2-siRNA delivery to the tumor. ..
  48. Matsuzawa Y, Oshima S, Takahara M, Maeyashiki C, Nemoto Y, Kobayashi M, et al. TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy. Autophagy. 2015;11:1052-62 pubmed publisher
    ..Taken together, our findings illustrate that TNFAIP3 restricts MTOR signaling and promotes autophagy, providing new insight into the manner in which MTOR and autophagy regulate survival in CD4 T cells. ..
  49. Lyu Z, Zhao B, Koiwai K, Hirono I, Kondo H. Identification of endonuclease domain-containing 1 gene in Japanese flounder Paralichthys olivaceus. Fish Shellfish Immunol. 2016;50:43-9 pubmed publisher
    ..The DNase activity of extracted protein was higher in treated fish than in untreated fish. Since the mRNA levels were significantly up-regulated after the FKC treatment, Jf_ENDOD1 might be responsible for the activities. ..
  50. Suzuki N, Hanmoto T, Yano S, Furusawa Y, Ikegame M, Tabuchi Y, et al. Low-intensity pulsed ultrasound induces apoptosis in osteoclasts: Fish scales are a suitable model for the analysis of bone metabolism by ultrasound. Comp Biochem Physiol A Mol Integr Physiol. 2016;195:26-31 pubmed publisher
    ..Thus, we are the first to demonstrate that LIPUS directly functions to osteoclasts and to conclude that LIPUS directly causes apoptosis in osteoclasts shortly after exposure. ..
  51. Takai S, Sakonjo H, Jin D. Comparison of the relative importance of vascular and plasma drug concentrations to the hypotensive effect of telmisartan in rats. J Renin Angiotensin Aldosterone Syst. 2016;17:1470320316633895 pubmed publisher
    ..2% at 24 h. The vascular drug concentration, not the plasma drug concentration, may be related to the hypotensive effect after administration of telmisartan. ..
  52. Miyamoto Y, Yamada K, Yoneda Y. Importin ?: a key molecule in nuclear transport and non-transport functions. J Biochem. 2016;160:69-75 pubmed publisher
    ..These findings enrich our knowledge of how importin ?s actively contribute to various cellular events. ..
  53. Fukamiya N, Okano M, Miyamoto M, Tagahara K, Lee K. Antitumor agents, 127. Bruceoside C, a new cytotoxic quassinoid glucoside, and related compounds from Brucea javanica. J Nat Prod. 1992;55:468-75 pubmed
    ..Bruceoside C showed potent cytotoxicities against KB, A-549, RPMI, and TE-671 tumor cells. ..
  54. Saito H, Kaba H, Sato T, Kondo M, Takeshima Y, Edashige N, et al. Influence of electrical stimulation of the hypothalamus on ovarian steroidogenesis in hypophysectomized and adrenalectomized rats. Exp Clin Endocrinol. 1990;95:259-61 pubmed
    ..From these results, it might be suggested that these hypothalamic structures were involved in the regulation of ovarian steroidogenesis without participation of the pituitary and adrenal. ..
  55. Kai C, Yoshikawa Y, Yamanouchi K. Activation of complement in quails bearing Rous sarcoma virus-induced tumors. J Vet Med Sci. 1995;57:1077-80 pubmed
    ..C3 deposition was also observed in almost all tumor cells at the tumor developing stage. These findings obtained in vivo suggest that the cells transformed by RSV activated the C3 on their surfaces...
  56. Takemura T, Sakagami M, Takebayashi K, Umemoto M, Nakase T, Takaoka K, et al. Localization of bone morphogenetic protein-4 messenger RNA in developing mouse cochlea. Hear Res. 1996;95:26-32 pubmed
    ..BMP-4 may be involved in the condensation and differentiation of the mesenchymal cells as well as basilar membrane formation. BMP-4 might be an essential factor for the normal development of the basilar membrane. ..
  57. Yamada J, Sugimoto Y, Yoshikawa T, Horisaka K. Hyperglycemia induced by the 5-HT receptor agonist, 5-methoxytryptamine, in rats: involvement of the peripheral 5-HT2A receptor. Eur J Pharmacol. 1997;323:235-40 pubmed
    ..Therefore, it is suggested that the 5-HT2A receptor may be partly involved in the pharmacological effects induced by the 5-HT4 receptor agonist, 5-methoxytryptamine. ..
  58. Matsuno H, Kozawa O, Niwa M, Ueshima S, Matsuo O, Collen D, et al. Differential role of components of the fibrinolytic system in the formation and removal of thrombus induced by endothelial injury. Thromb Haemost. 1999;81:601-4 pubmed
    ..In conclusion, t-PA increases the rate of clot lysis after endothelial injury, PAI-1 reduces the time to occlusion and delays clot lysis, whereas u-PA has little effect on thrombus formation and spontaneous lysis. ..
  59. Zinchuk V, Okada T, Seguchi H. Lipopolysaccharide alters ecto-ATP-diphosphohydrolase and causes relocation of its reaction product in experimental intrahepatic cholestasis. Cell Tissue Res. 2001;304:103-9 pubmed
    ..It is suggested that relocation of the reaction product may be a protective mechanism to enable the hepatocytes to withstand the cytokine-induced metabolic perturbations. ..
  60. Iemitsu M, Miyauchi T, Maeda S, Tanabe T, Takanashi M, Irukayama Tomobe Y, et al. Aging-induced decrease in the PPAR-alpha level in hearts is improved by exercise training. Am J Physiol Heart Circ Physiol. 2002;283:H1750-60 pubmed
  61. Maesawa S, Kaneoke Y, Kajita Y, Usui N, Misawa N, Nakayama A, et al. Long-term stimulation of the subthalamic nucleus in hemiparkinsonian rats: neuroprotection of dopaminergic neurons. J Neurosurg. 2004;100:679-87 pubmed
    ..Subthalamic nucleus stimulation thus appears to protect dopaminergic neurons in this hemiparkinsonian model, in addition to improving motor function in these animals. ..
  62. Tanaka S, Mannen K, Sato H. Use of herpesvirus papio 2 as an alternative antigen in immunoblotting assay for B virus diagnosis. J Vet Med Sci. 2004;66:529-32 pubmed
    ..No specific bands could be detected with BV-negative sera. These results show the usefulness of HVP2 antigen as an alternative and safer antigen than authentic BV antigen in detecting BV antibody in immunoblotting. ..
  63. Takimoto Ohnishi E, Saito T, Ishida J, Ohnishi J, Sugiyama F, Yagami K, et al. Differential roles of renin and angiotensinogen in the feto-maternal interface in the development of complications of pregnancy. Mol Endocrinol. 2005;19:1361-72 pubmed
    ..This study provides in vivo evidence that the cell-specific expression of RN and ANG in the feto-maternal interface impacts their differential roles in pregnancy. ..
  64. Uematsu S, Sato S, Yamamoto M, Hirotani T, Kato H, Takeshita F, et al. Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction. J Exp Med. 2005;201:915-23 pubmed
    ..These results indicated that IRAK-1 is a specific regulator for TLR7- and TLR9-mediated IFN-alpha induction in pDCs. ..
  65. Misawa R, Ise H, Takahashi M, Morimoto H, Kobayashi E, Miyagawa S, et al. Development of liver regenerative therapy using glycoside-modified bone marrow cells. Biochem Biophys Res Commun. 2006;342:434-40 pubmed
    ..These findings suggest that the functional BMC-derived hepatocytes can be generated by the direct accumulation of BMCs and that this strategy is new BMC therapy for liver regeneration. ..
  66. Yamamoto Y, Taniguchi K. Expression of ENaC subunits in sensory nerve endings in the rat larynx. Neurosci Lett. 2006;402:227-32 pubmed
    ..In the larynx, ENaC channels may play important roles in mechanotransduction in the laminar endings and in the mechano- and chemotransductions in the taste bud-associated nerve fibers. ..
  67. Sato K, Suematsu A, Nakashima T, Takemoto Kimura S, Aoki K, Morishita Y, et al. Regulation of osteoclast differentiation and function by the CaMK-CREB pathway. Nat Med. 2006;12:1410-6 pubmed
    ..This provides a molecular basis for a new therapeutic strategy for bone diseases. ..
  68. Niikura K, Nakajima S, Takano M, Yamazaki H. FR177995, a novel vacuolar ATPase inhibitor, exerts not only an inhibitory effect on bone destruction but also anti-immunoinflammatory effects in adjuvant-induced arthritic rats. Bone. 2007;40:888-94 pubmed
    ..These results strongly suggest that V-ATPase may be an interesting drug target in the treatment of rheumatoid arthritis. ..
  69. Nishida H, Kushida M, Nakajima Y, Ogawa Y, Tatewaki N, Sato S, et al. Amyloid-beta-induced cytotoxicity of PC-12 cell was attenuated by Shengmai-san through redox regulation and outgrowth induction. J Pharmacol Sci. 2007;104:73-81 pubmed
    ..It may also be beneficial not only for the treatment of brain disorders but also for other diseases caused by oxidative stress. ..
  70. Horiguchi T, Nishikawa T, Ohta Y, Shiraishi H, Morita M. Retinoid X receptor gene expression and protein content in tissues of the rock shell Thais clavigera. Aquat Toxicol. 2007;84:379-88 pubmed
    ..RXR could be involved in the mechanism of induction of male-type genitalia (penis and vas deferens) by organotin compounds in female rock shells. ..
  71. Tsunematsu T, Fu L, Yamanaka A, Ichiki K, Tanoue A, Sakurai T, et al. Vasopressin increases locomotion through a V1a receptor in orexin/hypocretin neurons: implications for water homeostasis. J Neurosci. 2008;28:228-38 pubmed publisher
    ..This system appears to play a key role in water deprivation-induced hyperlocomotor activity, a response to dehydration that increases the chance of locating water in nature. ..
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