Experts and Doctors on animals in Canada


Locale: Canada
Topic: animals

Top Publications

  1. Zhang Q, Wrana J, Sodek J. Characterization of the promoter region of the porcine opn (osteopontin, secreted phosphoprotein 1) gene. Identification of positive and negative regulatory elements and a 'silent' second promoter. Eur J Biochem. 1992;207:649-59 pubmed
    ..Setoguchi, M., Yoshida, S., Higuchi, Y., Akizuki, S. & Yamamoto, S. (1990) J. Biol. Chem. 265, 14432-14438).(ABSTRACT TRUNCATED AT 400 WORDS) ..
  2. Gupta K, Copeland N, Gilbert D, Jenkins N, Gray D. Unp, a mouse gene related to the tre oncogene. Oncogene. 1993;8:2307-10 pubmed
    ..We have localized the Unp gene to mouse chromosome 9 in a region of homology with human chromosome 3p. This region has been implicated in a number of human malignancies. ..
  3. Beaulieu M, Levesque E, Hum D, Belanger A. Isolation and characterization of a novel cDNA encoding a human UDP-glucuronosyltransferase active on C19 steroids. J Biol Chem. 1996;271:22855-62 pubmed
    ..UGT2B17 is the first human uridine diphosphoglucuronosyltransferase enzyme expressed in extrahepatic tissues to have a specificity for ADT as well as testosterone, dihydrotestosterone, and 3alpha-diol. ..
  4. Zhu L, Ohan N, Agazie Y, Cummings C, Farah S, Liu X. Molecular cloning and characterization of Xenopus insulin-like growth factor-1 receptor: its role in mediating insulin-induced Xenopus oocyte maturation and expression during embryogenesis. Endocrinology. 1998;139:949-54 pubmed
    ..We also report here that embryonic transcription of xIGF-1 receptor is activated during the formation of the central nervous system in early Xenopus embryos. ..
  5. Duong M, Ouellet N, Simard M, Bergeron Y, Olivier M, Bergeron M. Kinetic study of host defense and inflammatory response to Aspergillus fumigatus in steroid-induced immunosuppressed mice. J Infect Dis. 1998;178:1472-82 pubmed
    ..These insights may be useful in the development of new treatment strategies for pulmonary aspergillosis. ..
  6. Cybulsky M, Lichtman A, Hajra L, Iiyama K. Leukocyte adhesion molecules in atherogenesis. Clin Chim Acta. 1999;286:207-18 pubmed
    ..Finally, ongoing studies are summarized which utilize transgenic mice to assess the roles of individual adhesion molecules in atherosclerotic lesion formation...
  7. Gutkowska J, Jankowski M, Mukaddam Daher S, McCann S. Oxytocin is a cardiovascular hormone. Braz J Med Biol Res. 2000;33:625-33 pubmed
    ..Therefore, locally produced OT may have important regulatory functions within the heart and vascular beds. Such functions may include slowing down of the heart or the regulation of local vascular tone. ..
  8. Dong H, Dunn J, Lytton J. Stoichiometry of the Cardiac Na+/Ca2+ exchanger NCX1.1 measured in transfected HEK cells. Biophys J. 2002;82:1943-52 pubmed
    ..9-2.3 ions per net charge and for Ca2+ of 0.45 +/- 0.03 ions per net charge. These data are consistent with a stoichiometry for the NCX1.1 protein of 4 Na+ to 1 Ca2+ to 2 charges moved per transport cycle. ..
  9. Pagé E, Robitaille G, Pouyssegur J, Richard D. Induction of hypoxia-inducible factor-1alpha by transcriptional and translational mechanisms. J Biol Chem. 2002;277:48403-9 pubmed
    ..Elucidation of these signaling pathways that up-regulate the vascular endothelial growth factor (VEGF) could have a strong impact on different aspects of vascular biology. ..

More Information

Publications702 found, 100 shown here

  1. Sik A, Passer B, Koonin E, Pellegrini L. Self-regulated cleavage of the mitochondrial intramembrane-cleaving protease PARL yields Pbeta, a nuclear-targeted peptide. J Biol Chem. 2004;279:15323-9 pubmed
  2. Gupta N, Ly T, Zhang Q, Kaufman P, Weinreb R, Yucel Y. Chronic ocular hypertension induces dendrite pathology in the lateral geniculate nucleus of the brain. Exp Eye Res. 2007;84:176-84 pubmed
    ..The striking dendrite changes in the LGN following chronically elevated intraocular pressure may be relevant to early visual dysfunction in glaucoma. ..
  3. Fairn G, Macdonald K, McMaster C. A chemogenomic screen in Saccharomyces cerevisiae uncovers a primary role for the mitochondria in farnesol toxicity and its regulation by the Pkc1 pathway. J Biol Chem. 2007;282:4868-74 pubmed
    ..The Pkc1 signaling pathway regulates farnesol-mediated cell death through management of the generation of reactive oxygen species. ..
  4. Drouin J, Bilodeau S, Vallette S. Of old and new diseases: genetics of pituitary ACTH excess (Cushing) and deficiency. Clin Genet. 2007;72:175-82 pubmed
    ..These recent advances have provided improved diagnosis and opened new perspectives for patient management and therapies. ..
  5. Aizawa Y, Leipzig N, Zahir T, Shoichet M. The effect of immobilized platelet derived growth factor AA on neural stem/progenitor cell differentiation on cell-adhesive hydrogels. Biomaterials. 2008;29:4676-83 pubmed publisher
    ..immobilized PDGF-AA. These results demonstrate for the first time, that it is possible to control the differentiation of NSPCs, and specifically to oligodendrocytes, in cell-adhesive matrices with immobilized PDGF-AA. ..
  6. Martin M, Azzi A, Lin S, Boivin G. Opposite effect of two cytomegalovirus DNA polymerase mutations on replicative capacity and polymerase activity. Antivir Ther. 2010;15:579-86 pubmed publisher
    ..The HCMV DNA polymerase mutation K805Q improved the fitness of the T821I mutation associated with high levels of resistance to foscarnet. ..
  7. Lavoie E, Gulbransen B, Martín Satué M, Aliagas E, Sharkey K, Sevigny J. Ectonucleotidases in the digestive system: focus on NTPDase3 localization. Am J Physiol Gastrointest Liver Physiol. 2011;300:G608-20 pubmed publisher
  8. Pant S, Verschoor C, Skelding A, Schenkel F, You Q, Biggar G, et al. Bovine IFNGR2, IL12RB1, IL12RB2, and IL23R polymorphisms and MAP infection status. Mamm Genome. 2011;22:583-8 pubmed publisher
    ..These results underscore the importance of cytokines and their receptors in conferring protection against MAP infection and warrant further functional characterization of these associations...
  9. Shan J, Liao J, Huang J, Robert R, Palmer M, Fahrenkrug S, et al. Bicarbonate-dependent chloride transport drives fluid secretion by the human airway epithelial cell line Calu-3. J Physiol. 2012;590:5273-97 pubmed publisher
    ..The results suggest a model in which most HCO(3)(-) is recycled basolaterally by exchange with Cl(-), and the resulting HCO(3)(-)-dependent Cl(-) transport provides an osmotic driving force for fluid secretion. ..
  10. de Passillé A, Rushen J. Adjusting the weaning age of calves fed by automated feeders according to individual intakes of solid feed. J Dairy Sci. 2012;95:5292-5298 pubmed publisher
  11. Rouleau L, Berti R, Ng V, Matteau Pelletier C, Lam T, Saboural P, et al. VCAM-1-targeting gold nanoshell probe for photoacoustic imaging of atherosclerotic plaque in mice. Contrast Media Mol Imaging. 2013;8:27-39 pubmed publisher
    ..These immunonanoshells represent an adequate mean to target atherosclerotic plaques in small animals, leading to new tools to follow the effect of therapies on the progression or regression of the disease. ..
  12. Barton A, Pershing A, Litchman E, Record N, Edwards K, Finkel Z, et al. The biogeography of marine plankton traits. Ecol Lett. 2013;16:522-34 pubmed publisher
    ..Thus, in addition to recommending widespread adoption of the trait-based approach, we advocate for enhanced collection, standardisation and dissemination of plankton functional trait data...
  13. Ferreira T, Blackman A, Oyrer J, Jayabal S, Chung A, Watt A, et al. Neuronal morphometry directly from bitmap images. Nat Methods. 2014;11:982-4 pubmed publisher
  14. Lan M, Li H, Bao L, Li M, Lye S, Dong X. In Vivo Evidence of the Androgen Receptor in Association With Myometrial Cell Proliferation and Apoptosis. Reprod Sci. 2016;23:264-71 pubmed publisher
    ..These results suggest that AR is an important regulator of myometrial growth in vivo during pregnancy and in leiomyoma. ..
  15. Grassl G, Finlay B. Pathogenesis of enteric Salmonella infections. Curr Opin Gastroenterol. 2008;24:22-6 pubmed
    ..The use of various animal models has greatly advanced understanding of Salmonella pathogenesis at intestinal and systemic sites. This review will emphasize recent advances in the understanding of intestinal Salmonella infections...
  16. Archambault V, Pinson X. Free centrosomes: where do they all come from?. Fly (Austin). 2010;4:172-7 pubmed
    ..These studies can inform on the biology of centrosomes, cell cycle regulation and cytoskeletal dynamics. Here we briefly discuss what to make of free centrosomes in the fly embryo. ..
  17. Gendron R, Laver N, Good W, Grossniklaus H, Miskiewicz E, Whelan M, et al. Loss of tubedown expression as a contributing factor in the development of age-related retinopathy. Invest Ophthalmol Vis Sci. 2010;51:5267-77 pubmed publisher
  18. Perry J, Rowe L. Rapid microsatellite development for water striders by next-generation sequencing. J Hered. 2011;102:125-9 pubmed publisher
    ..The current study demonstrates an effective method for microsatellite development and shows that light sequencing of genomic DNA can provide numerous and highly variable markers. ..
  19. Filali M, Lalonde R. Neurobehavioral Anomalies in the Pitx3/ak Murine Model of Parkinson's Disease and MPTP. Behav Genet. 2016;46:228-41 pubmed publisher
    ..Increased hindlimb clasping time and rotorod deficits seen in mutants were also exhibited by mice injected with MPTP, indicating an influence of dopamine on these behaviors. ..
  20. Corbeil D, Gaudoux F, Wainwright S, Ingram J, Kenny A, Boileau G, et al. Molecular cloning of the alpha-subunit of rat endopeptidase-24.18 (endopeptidase-2) and co-localization with endopeptidase-24.11 in rat kidney by in situ hybridization. FEBS Lett. 1992;309:203-8 pubmed
    ..18 with endopeptidase-24.11 in proximal tubules of juxtamedullary nephrons, suggesting that the two enzymes have similar or complementary physiological functions in kidney. ..
  21. Julien J, Tretjakoff I, Beaudet L, Peterson A. Expression and assembly of a human neurofilament protein in transgenic mice provide a novel neuronal marking system. Genes Dev. 1987;1:1085-95 pubmed
    ..Finally, immunohistochemical localization of the human NF-L protein results in the specific staining of neurons and their processes in transgenic mice. ..
  22. Johnston R, Kucey B. Competitive inhibition of hsp70 gene expression causes thermosensitivity. Science. 1988;242:1551-4 pubmed
    ..These results support a role for heat shock protein in the recovery of mammalian cells from acute thermal stress. ..
  23. Wen T, Zhang L, Kung S, Molina T, Miller R, Mak T. Allo-skin graft rejection, tumor rejection and natural killer activity in mice lacking p56lck. Eur J Immunol. 1995;25:3155-9 pubmed
    ..The normal NK activity in lck -/- mice suggests that p56lck is not required for the development and activation of NK cells. ..
  24. Cote J, Ruiz Carrillo A. Primers for mitochondrial DNA replication generated by endonuclease G. Science. 1993;261:765-9 pubmed
    ..The cleavage sites match those found in vivo, indicating that Endo G is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. ..
  25. Wiebe G, Fung E, Biddle F, Snyder F. A twenty strain survey and backcross localization of the erythrocytic GTP concentration determining locus Gtpc on mouse chromosome 9. Genome. 1999;42:447-52 pubmed
  26. Gabra B, Benrezzak O, Pheng L, Duta D, Daull P, Sirois P, et al. Inhibition of type 1 diabetic hyperalgesia in streptozotocin-induced Wistar versus spontaneous gene-prone BB/Worchester rats: efficacy of a selective bradykinin B1 receptor antagonist. J Neuropathol Exp Neurol. 2005;64:782-9 pubmed
    ..Thus, selective antagonism of the inducible BKB1-R subtype may constitute a novel and potential therapeutic approach for the treatment of PDN. ..
  27. Morisset J. The gastrointestinal cholecystokinin receptors in health and diseases. Rocz Akad Med Bialymst. 2005;50:21-36 pubmed
  28. Thibodeau B, Teixeira F, Yamauchi M, Caplan D, Trope M. Pulp revascularization of immature dog teeth with apical periodontitis. J Endod. 2007;33:680-9 pubmed
    ..9%, apical closure in 54.9%, and new luminal tissue in 29.3%). Revascularization of disinfected immature dog root canal systems is possible. ..
  29. Mathew J, Galarneau L, Loranger A, Gilbert S, Marceau N. Keratin-protein kinase C interaction in reactive oxygen species-induced hepatic cell death through mitochondrial signaling. Free Radic Biol Med. 2008;45:413-24 pubmed publisher
    ..Together, these results point to a key regulatory function for K8/K18 in ROS-induced mitochondria-mediated death through PKCdelta involvement in hepatic cells. ..
  30. Drolet M, Couet J, Arsenault M. Development of aortic valve sclerosis or stenosis in rabbits: role of cholesterol and calcium. J Heart Valve Dis. 2008;17:381-7 pubmed
    ..These findings support the hypothesis that a combination of atherosclerotic and calcifying factors is necessary to induce aortic valve stenosis in this model. ..
  31. Wu D, Barrett D, Rawlings N, Giffin J, Bartlewski P. Relationships of changes in ultrasonographic image attributes to ovulatory and steroidogenic capacity of large antral follicles in sheep. Anim Reprod Sci. 2009;116:73-84 pubmed publisher
    ..The differences in follicular echotexture appear to be related mainly to seasonal variations in ovarian follicular morphology and oestradiol production. ..
  32. Ghavami S, Eshraghi M, Kadkhoda K, Mutawe M, Maddika S, Bay G, et al. Role of BNIP3 in TNF-induced cell death--TNF upregulates BNIP3 expression. Biochim Biophys Acta. 2009;1793:546-60 pubmed publisher
    ..Together, these data indicate that TNF-induced cell death involves BNIP3, ROS production, and activation of the lysosomal death pathway. ..
  33. Wu Q, Henry J. Delayed onset of changes in soma action potential genesis in nociceptive A-beta DRG neurons in vivo in a rat model of osteoarthritis. Mol Pain. 2009;5:57 pubmed publisher
    ..Thus, if changes in Abeta-fiber nociceptive neurons in this model reflect a role in OA pain, they may relate to mechanisms underlying pain associated with advanced OA. ..
  34. Sharma M, Seidlitz E, Singh G. Cancer cells release glutamate via the cystine/glutamate antiporter. Biochem Biophys Res Commun. 2010;391:91-5 pubmed publisher
    ..Pharmacological interference with cancer cell glutamate release may be a viable option for limiting host bone response to invading tumor cells in bone metastasis. ..
  35. Zulak K, Bohlmann J. Terpenoid biosynthesis and specialized vascular cells of conifer defense. J Integr Plant Biol. 2010;52:86-97 pubmed publisher
    ..Formation of these resin ducts de novo in the cambium zone and developing xylem, following insect attack or treatment of trees with methyl jasmonate, is a unique feature of the induced defense of long-lived conifer trees. ..
  36. Fichna J, Gach K, Perlikowska R, Cravezic A, Bonnet J, do Rego J, et al. Novel endomorphin analogues with antagonist activity at the mu-opioid receptor in the gastrointestinal tract. Regul Pept. 2010;162:109-14 pubmed publisher
    ..Antanal-1, antanal-2, and antanal-2A are promising MOR antagonists with limited BBB permeability, which may be developed into future therapeutics of opioid-related GI dysfunction. ..
  37. Sheppard S, Long J, Sanipelli B. Measured elemental transfer factors for boreal hunter/gatherer scenarios: fish, game and berries. J Environ Radioact. 2010;101:902-9 pubmed publisher
  38. Ward R. An update on disordered iron metabolism and iron overload. Hematology. 2010;15:311-7 pubmed publisher
  39. Oubaha M, Lin M, Margaron Y, Filion D, Price E, Zon L, et al. Formation of a PKC?/?-catenin complex in endothelial cells promotes angiopoietin-1-induced collective directional migration and angiogenic sprouting. Blood. 2012;120:3371-81 pubmed publisher
    ..These results reveal that PKC? and ?-catenin function in a complex at adherens junctions and at the leading edge of migrating endothelial cells to modulate collective and directional migration during angiogenesis. ..
  40. Lekas M, Lekas P, Mei S, Deng Y, Dumont D, Stewart D. Tie2-dependent neovascularization of the ischemic hindlimb is mediated by angiopoietin-2. PLoS ONE. 2012;7:e43568 pubmed publisher
  41. Bernier G, Brown A, Dalpé G, Mathieu M, De Repentigny Y, Kothary R. Dystonin transcripts are altered and their levels are reduced in the mouse neurological mutant dt24J. Biochem Cell Biol. 1995;73:605-9 pubmed
    ..Here we show that abnormal dystonin transcripts are present in neural tissues of a spontaneous dystonia musculorum mutant, dt24J. We further show that dystonin transcript levels are reduced 2- to 3-fold in dt24J mice. ..
  42. Bodoor K, Shaikh S, Enarson P, Chowdhury S, Salina D, Raharjo W, et al. Function and assembly of nuclear pore complex proteins. Biochem Cell Biol. 1999;77:321-9 pubmed
    ..These findings support a model in which it is POM121 rather than gp210 that defines initial membrane-associated NPC assembly intermediates and which may therefore represent an essential component of the central framework of the NPC. ..
  43. Tsoporis J, Marks A, Van Eldik L, O Hanlon D, Parker T. Regulation of the S100B gene by alpha 1-adrenergic stimulation in cardiac myocytes. Am J Physiol Heart Circ Physiol. 2003;284:H193-203 pubmed
    ..Our results suggest that alpha(1)-adrenergic stimulation induces the S100B gene after myocardial infarction through the PKC signaling pathway and that this induction is modulated by TEF-1 and RTEF-1. ..
  44. Chabowski A, Coort S, Calles Escandon J, Tandon N, Glatz J, Luiken J, et al. The subcellular compartmentation of fatty acid transporters is regulated differently by insulin and by AICAR. FEBS Lett. 2005;579:2428-32 pubmed
  45. Barnabe Heider F, Wasylnka J, Fernandes K, Porsche C, Sendtner M, Kaplan D, et al. Evidence that embryonic neurons regulate the onset of cortical gliogenesis via cardiotrophin-1. Neuron. 2005;48:253-65 pubmed
  46. Avon S, Wood R. Porcine skin as an in-vivo model for ageing of human bite marks. J Forensic Odontostomatol. 2005;23:30-9 pubmed
    ..Under these experimental conditions, the results suggest that an in-vivo porcine skin model should be considered as a representative model for the study of human bite marks...
  47. Chan A, Owens S, Tung C, Stanley E. Resistance of presynaptic CaV2.2 channels to voltage-dependent inactivation: dynamic palmitoylation and voltage sensitivity. Cell Calcium. 2007;42:419-25 pubmed
    ..2. However, some other factor must also contribute since its inhibition does is not restore the inactivation profile to that of channels in the cell soma. ..
  48. McDonald B, McAvoy E, Lam F, Gill V, de la Motte C, Savani R, et al. Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids. J Exp Med. 2008;205:915-27 pubmed publisher
  49. Gamage L, Ellis J, Hayes S. Immunogenicity of bacteriophage lambda particles displaying porcine Circovirus 2 (PCV2) capsid protein epitopes. Vaccine. 2009;27:6595-604 pubmed publisher
    ..Neither LDP-D-CAP nor the lambda control elicited any untoward local or systemic reactions following immunization. These studies produced the first potential phage vaccine to porcine Circovirus 2. ..
  50. Aubin E, Lemieux R, Bazin R. Indirect inhibition of in vivo and in vitro T-cell responses by intravenous immunoglobulins due to impaired antigen presentation. Blood. 2010;115:1727-34 pubmed publisher
    ..Such inhibition of T-cell responses by reducing antigen presentation may therefore contribute to the well-known anti-inflammatory effects of IVIg in autoimmune diseases. ..
  51. Smirle M, Zurowski C, Lowery D, Foottit R. Relationship of insecticide tolerance to esterase enzyme activity in Aphis pomi and Aphis spiraecola (Hemiptera: Aphididae). J Econ Entomol. 2010;103:374-8 pubmed
    ..pomi and A. spiraecola to insecticides indicated that the choice of control chemicals for A. spiraecola should not involve chemistries that are metabolized predominantly by esterases. ..
  52. Parvizi P, Abdul Careem M, Haq K, Thanthrige Don N, Schat K, Sharif S. Immune responses against Marek's disease virus. Anim Health Res Rev. 2010;11:123-34 pubmed publisher
    ..This review discusses our current understanding of immune responses elicited against MDV and genetic factors that contribute to the nature of the response. ..
  53. Sebé Pedrós A, de Mendoza A, Lang B, Degnan B, Ruiz Trillo I. Unexpected repertoire of metazoan transcription factors in the unicellular holozoan Capsaspora owczarzaki. Mol Biol Evol. 2011;28:1241-1254 pubmed publisher
    ..Nonetheless, TF families whose beginnings antedate the origin of the animal kingdom, such as homeodomain or basic helix-loop-helix, underwent significant expansion and diversification along metazoan and eumetazoan stems. ..
  54. Bucking C, Wood C. Digestion of a single meal affects gene expression of ion and ammonia transporters and glutamine synthetase activity in the gastrointestinal tract of freshwater rainbow trout. J Comp Physiol B. 2012;182:341-50 pubmed publisher
    ..These post-prandial changes occur over the relative short-term duration of digesting a single meal. ..
  55. Elkoreh G, Blais V, Béliveau E, Guillemette G, Denault J. Type 1 inositol-1,4,5-trisphosphate receptor is a late substrate of caspases during apoptosis. J Cell Biochem. 2012;113:2775-84 pubmed publisher
    ..Finally, using recombinant caspase-3 and microsomal fractions enriched in IP(3) R-1, we show that the receptor is a poor caspase-3 substrate. Consequently, we conclude that IP(3) R-1 is not a key death substrate. ..
  56. Somerville M, McLachlan D, Percy M. Localization of the 68,000-Da human neurofilament gene (NF68) using a murine cDNA probe. Genome. 1988;30:499-500 pubmed
    ..0001). In addition, we have found secondary hybridization sites at the centromeric region of chromosome 2 and the long arm of chromosome 7, which are putative loci for other intermediate filaments. ..
  57. Steriade M. Impact of network activities on neuronal properties in corticothalamic systems. J Neurophysiol. 2001;86:1-39 pubmed
    ..The results indicate that intact-brain preparations are necessary to investigate global brain functions such as behavioral states of vigilance and paroxysmal activities...
  58. Sugita M, Ferraro P, Dagenais A, Clermont M, Barbry P, Michel R, et al. Alveolar liquid clearance and sodium channel expression are decreased in transplanted canine lungs. Am J Respir Crit Care Med. 2003;167:1440-50 pubmed
    ..Therefore, we conclude that the current investigation indicates that the lung injury caused by lung preservation and transplantation significantly reduces the edema clearance ability of transplanted lungs. ..
  59. Matthews B, Mazumder A. Habitat specialization and the exploitation of allochthonous carbon by zooplankton. Ecology. 2006;87:2800-12 pubmed
    ..Therefore, the fate of allochthonous carbon subsidies to lakes depends on spatially explicit consumer-resource interactions. ..
  60. Facci M, Auray G, Meurens F, Buchanan R, Van Kessel J, Gerdts V. Stability of expression of reference genes in porcine peripheral blood mononuclear and dendritic cells. Vet Immunol Immunopathol. 2011;141:11-5 pubmed publisher
    ..Recommendations for the use of reference genes include using GAPDH and B-actin in PBMCs: RPL19 and SDHA in T cells; RPL19 and B-actin in monocytes; RPL-19 and SDHA in BDCs: and RPL-19 and ATP5GA in MoDCs. ..
  61. Mena J, Kamen A. Insect cell technology is a versatile and robust vaccine manufacturing platform. Expert Rev Vaccines. 2011;10:1063-81 pubmed publisher
    ..We will probably observe increasingly more baculovirus-derived products and market licensing of safe and efficacious vaccines...
  62. De Giorgio M, Yoshioka M, Riedl I, Moreault O, Cherizol R, Shah A, et al. Trefoil factor family member 2 (Tff2) KO mice are protected from high-fat diet-induced obesity. Obesity (Silver Spring). 2013;21:1389-95 pubmed publisher
    ..The present work demonstrates previously unsuspected roles for Tff2 and suggests it to be a mastermind in the control of energy balance and a promising therapeutic target for obesity. ..
  63. Aoidi R, Maltais A, Charron J. Functional redundancy of the kinases MEK1 and MEK2: Rescue of the Mek1 mutant phenotype by Mek2 knock-in reveals a protein threshold effect. Sci Signal. 2016;9:ra9 pubmed publisher
    ..Thus, although MEK1 and MEK2 can substitute for each other, a minimum amount of MEK is critical for placenta development and embryo survival. ..
  64. Ponton D, Caron A, Hare L, Campbell P. Hepatic oxidative stress and metal subcellular partitioning are affected by selenium exposure in wild yellow perch (Perca flavescens). Environ Pollut. 2016;214:608-617 pubmed publisher
    ..High Cd concentrations in metal-sensitive subcellular fractions likely further exacerbate the negative effects of lower Se exposure. ..
  65. Van der Gaag H, Axelrad A. Friend virus replication in normal and immunosuppressed C57BL/6 mice. Virology. 1990;177:837-9 pubmed
    ..2 monoclonal antibody iv before FV infection permitted continued replication of SFFV in these animals. This finding strongly supports the hypothesis that SFFV replication in C57BL/6 mice is restricted by a T cell-mediated immune response...
  66. Aloyz R, DesGroseillers L. Processing of the L5-67 precursor peptide and characterization of LUQIN in the LUQ neurons of Aplysia californica. Peptides. 1995;16:331-8 pubmed
    ..The amidation of LUQIN was further demonstrated by its resistance to carboxypeptidase A digestion. ..
  67. Petric R, Nicholson D, Ford Hutchinson A. Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis. Biochim Biophys Acta. 1995;1254:207-15 pubmed
    ..05). These results suggest a potential mechanism for enhanced cysteinyl LT formation in the development of experimental GN and further support their causal role in the etiology of this disease. ..
  68. Ren W, Ng G, Wang R, Wu P, O Dowd B, Osmond D, et al. The identification of NP25: a novel protein that is differentially expressed by neuronal subpopulations. Brain Res Mol Brain Res. 1994;22:173-85 pubmed
    ..The wide and differential distribution of NP25 in the brain suggests that it may play a particular important role in the function of specific neuronal systems. ..
  69. Zhang L, Han D, Carlen P. Temporal specificity of muscarinic synaptic modulation of the Ca(2+)-dependent K+ current (ISAHP) in rat hippocampal neurones. J Physiol. 1996;496 ( Pt 2):395-405 pubmed
  70. Brandes L, Queen G, LaBella F. Displacement of histamine from liver cells and cell components by ligands for cytochromes P450. J Cell Biochem. 2002;85:820-4 pubmed
  71. Burgess J, Kiss R, Zheng H, Zachariah S, Marcel Y. Trypsin-sensitive and lipid-containing sites of the macrophage extracellular matrix bind apolipoprotein A-I and participate in ABCA1-dependent cholesterol efflux. J Biol Chem. 2002;277:31318-26 pubmed
    ..These studies establish a novel binding site for apoA-I on the macrophage ECM that may function together with ABCA1 in promoting cholesterol efflux...
  72. Vieira O, Bucci C, Harrison R, Trimble W, Lanzetti L, Gruenberg J, et al. Modulation of Rab5 and Rab7 recruitment to phagosomes by phosphatidylinositol 3-kinase. Mol Cell Biol. 2003;23:2501-14 pubmed
    ..We propose that Rab5 activates both PI3K-dependent and PI3K-independent effectors that act in parallel to promote phagosome maturation. ..
  73. Chen F, Tandon A, Sanjo N, Gu Y, Hasegawa H, Arawaka S, et al. Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain. J Biol Chem. 2003;278:19974-9 pubmed
    ..Our data therefore suggest that the differential interactions of PS1 and PS2 with nicastrin reflect different functions for the PS1 and PS2 complexes. ..
  74. Onishi I, Lin P, Diering G, Williams W, Numata M. RACK1 associates with NHE5 in focal adhesions and positively regulates the transporter activity. Cell Signal. 2007;19:194-203 pubmed
    ..We propose that RACK1 activates NHE5 both by integrin-dependent and independent pathways, which may coordinate cellular ion homeostasis during cell-matrix adhesion. ..
  75. Pata M, Héraud C, Vacher J. OSTM1 bone defect reveals an intercellular hematopoietic crosstalk. J Biol Chem. 2008;283:30522-30 pubmed publisher
    ..Together these experiments are the first to demonstrate the existence of hematopoietic crosstalk for the production of functional and active osteoclasts. ..
  76. Sangwan V, Paliouras G, Abella J, Dubé N, Monast A, Tremblay M, et al. Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase. J Biol Chem. 2008;283:34374-83 pubmed publisher
    ..Our data demonstrate that PTP1B and TCPTP play distinct and non-redundant roles in the regulation of the Met receptor-tyrosine kinase. ..
  77. Michaud J, Nolin T, Naud J, Dani M, Lafrance J, Leblond F, et al. Effect of hemodialysis on hepatic cytochrome P450 functional expression. J Pharmacol Sci. 2008;108:157-63 pubmed
    ..This is the first study to demonstrate that conventional hemodialysis acutely improves altered CYP functional expression observed in rat hepatocytes incubated with uremic human serum. ..
  78. Or Rashid M, Wright T, McBride B. Microbial fatty acid conversion within the rumen and the subsequent utilization of these fatty acids to improve the healthfulness of ruminant food products. Appl Microbiol Biotechnol. 2009;84:1033-43 pubmed publisher
    ..We conclude that most current functional food products from ruminants have potential for their health-supporting properties, and for this market to succeed, an evidence-based approach should be developed in humans. ..
  79. Hermawan H, Dube D, Mantovani D. Developments in metallic biodegradable stents. Acta Biomater. 2010;6:1693-7 pubmed publisher
    ..By referring to patents and journal publications, this paper reviews the developments in biodegradable stents, with emphasis on those made of metals, starting from the first design ideas to validation testing. ..
  80. Mandeville J, Tajmir Riahi H. Complexes of dendrimers with bovine serum albumin. Biomacromolecules. 2010;11:465-72 pubmed publisher
    ..3) x 10(4) M(-1), and K(PAMAM-G4) = 1.1 (+/-0.4) x 10(4) M(-1). Dendrimer binding altered BSA conformation with a major reduction of alpha-helix and an increase in random coil and turn structures, indicating a partial protein unfolding. ..
  81. Savard C, Guerin A, Drouin K, Bolduc M, Laliberté Gagné M, Dumas M, et al. Improvement of the trivalent inactivated flu vaccine using PapMV nanoparticles. PLoS ONE. 2011;6:e21522 pubmed publisher
    ..Thus, seasonal flu vaccine adjuvanted with PapMV nanoparticles can induce universal protection to influenza, which is a major advancement when facing a pandemic...
  82. Hillier N, Vickers N. Hairpencil volatiles influence interspecific courtship and mating between two related moth species. J Chem Ecol. 2011;37:1127-36 pubmed publisher
    ..subflexa HP extract. This suggests that HP volatiles produced by males of each species may inhibit mating between species through effects on males (H. virescens) and females (H. subflexa). ..
  83. Nemati F, Kolb B. Recovery from medial prefrontal cortex injury during adolescence: implications for age-dependent plasticity. Behav Brain Res. 2012;229:168-75 pubmed publisher
    ..Almost opposite pattern of recovery following motor cortex and medial prefrontal injuries in early and late adolescence will be discussed as an age-area dependent model for prognosis of brain injury during adolescence. ..
  84. Irimia M, Blencowe B. Alternative splicing: decoding an expansive regulatory layer. Curr Opin Cell Biol. 2012;24:323-32 pubmed publisher
    ..Particularly intriguing is the discovery of new AS 'switches' that control transcriptional networks required for animal development and behavior. ..
  85. Viré E, Curtis C, Davalos V, Git A, Robson S, Villanueva A, et al. The breast cancer oncogene EMSY represses transcription of antimetastatic microRNA miR-31. Mol Cell. 2014;53:806-18 pubmed publisher
    ..Altogether, these results suggest a pathway underlying the role of EMSY in breast cancer and uncover potential diagnostic and therapeutic targets in sporadic breast cancer. ..
  86. Green D, Duffy M, Janz D, McCullum K, Carrière G, Jardine T. Historical and Contemporary Patterns of Mercury in a Hydroelectric Reservoir and Downstream Fishery: Concentration Decline in Water and Fishes. Arch Environ Contam Toxicol. 2016;71:157-70 pubmed publisher
    ..Together, these results suggest connected contamination between the two sites and delineate the timeline during which [Hg] in a variety of fish species decreased to nontoxic levels in both locations. ..
  87. Bellavance M, Takatoh J, Lu J, Demers M, Kleinfeld D, Wang F, et al. Parallel Inhibitory and Excitatory Trigemino-Facial Feedback Circuitry for Reflexive Vibrissa Movement. Neuron. 2017;95:673-682.e4 pubmed publisher
    ..Silencing this feedback alters retraction. The observed pull-push circuit at the lowest-level sensorimotor loop provides a mechanism for the rapid modulation of vibrissa touch during exploration of peri-personal space. ..
  88. Denis M. Recombinant interleukin-1 infusion increases resistance of BALB/c mice to murine leprosy. Int J Immunopharmacol. 1991;13:897-902 pubmed
    ..It is concluded that IL-1 alpha has immunotherapeutic potential in leprosy with the mechanism(s) of action still unclear...
  89. Ridsdale R, Semotok J, Larson D, Rothblum L, Harauz G. Topology of recombinant rat upstream binding factor. Biochem Cell Biol. 1998;76:649-55 pubmed
    ..Distinct nodes were observable, of size and spacing consistent with being HMG boxes 3 and 4. The dimerisation domain seemed most probably to be located in the internal region of the structure. ..
  90. Ingrey K, Ren J, Prescott J. A fluoroquinolone induces a novel mitogen-encoding bacteriophage in Streptococcus canis. Infect Immun. 2003;71:3028-33 pubmed
    ..The presence of this gene on a fluoroquinolone-induced bacteriophage may explain the association observed between fluoroquinolone use in dogs and the development of canine STTS and NF...
  91. Ujiie M, Dickstein D, Carlow D, Jefferies W. Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model. Microcirculation. 2003;10:463-70 pubmed
  92. Plane F, Johnson R, Kerr P, Wiehler W, Thorneloe K, Ishii K, et al. Heteromultimeric Kv1 channels contribute to myogenic control of arterial diameter. Circ Res. 2005;96:216-24 pubmed
    ..It is concluded that K(DR) channels composed of heteromultimers of Kv1 subunits play a critical role in myogenic control of arterial diameter. ..