Genomes and Genes
Experts and Doctors on animal disease models in United States
Locale: United States
Topic: animal disease models
Publications486 found, 100 shown here
- Volate S, Muga S, Issa A, Nitcheva D, Smith T, Wargovich M. Epigenetic modulation of the retinoid X receptor alpha by green tea in the azoxymethane-Apc Min/+ mouse model of intestinal cancer. Mol Carcinog. 2009;48:920-33 pubmed publisher..The results suggest that a low concentration of GT is sufficient to desilence RXR alpha and inhibit intestinal tumorigenesis in the Apc(Min/+) mouse...
- Sen U, Basu P, Abe O, Givvimani S, Tyagi N, Metreveli N, et al. Hydrogen sulfide ameliorates hyperhomocysteinemia-associated chronic renal failure. Am J Physiol Renal Physiol. 2009;297:F410-9 pubmed publisher..Additionally, here we demonstrate with evidence that H(2)S supplementation prevents HHcy-associated renal damage, in part, through its antioxidant properties. ..
- Hoeker G, Katra R, Wilson L, Plummer B, Laurita K. Spontaneous calcium release in tissue from the failing canine heart. Am J Physiol Heart Circ Physiol. 2009;297:H1235-42 pubmed publisher..e., an SCR), but importantly, it is the rate of SCR rise rather than amplitude that was associated with TA. ..
- Salerno E, Scaglione B, Coffman F, Brown B, Baccarini A, Fernandes H, et al. Correcting miR-15a/16 genetic defect in New Zealand Black mouse model of CLL enhances drug sensitivity. Mol Cancer Ther. 2009;8:2684-92 pubmed publisher..Our data support a role for the mir-15a/16-1 cluster in cell cycle regulation and suggest that these mature microRNAs in both the New Zealand Black model and human CLL may be targets for therapeutic efficacy in this disease. ..
- Khanna C, London C, Vail D, Mazcko C, Hirschfeld S. Guiding the optimal translation of new cancer treatments from canine to human cancer patients. Clin Cancer Res. 2009;15:5671-7 pubmed publisher..A summary of this meeting and subsequent discussion are provided here to afford clarity on the conduct of these studies so as to optimize the opportunities provided by this novel drug development and modeling strategy. ..
- Hoffman M, Witt R, Chapin W, McCulloch T, Jiang J. Multiparameter comparison of injection laryngoplasty, medialization laryngoplasty, and arytenoid adduction in an excised larynx model. Laryngoscope. 2010;120:769-76 pubmed publisher..To ensure optimal acoustic outcome, the arytenoid must be correctly rotated. This study provides objective support for the combined ML-AA procedure in tolerant patients. ..
- Sharma N, Moeller C, Marzo S, Jones K, Foecking E. Combinatorial treatments enhance recovery following facial nerve crush. Laryngoscope. 2010;120:1523-30 pubmed publisher..Administration of P neither augments nor hinders recovery. ..
- Chen J, Cheng Z, Miao Y, Jurisson S, Quinn T. Alpha-melanocyte-stimulating hormone peptide analogs labeled with technetium-99m and indium-111 for malignant melanoma targeting. Cancer. 2002;94:1196-201 pubmed
- Reilly C, Gilkeson G. Use of genetic knockouts to modulate disease expression in a murine model of lupus, MRL/lpr mice. Immunol Res. 2002;25:143-53 pubmed
- Garden G. Microglia in human immunodeficiency virus-associated neurodegeneration. Glia. 2002;40:240-51 pubmed..Several molecular mediators of neuronal injury in HAD that emanate from microglia have been identified, and strategies for altering the impact of these neurotoxins are discussed. ..
- Craig W. Proof of concept: performance testing in models. Clin Microbiol Infect. 2004;10 Suppl 2:12-7 pubmed..These data indicate the potential benefit of therapy with amoxicillin/clavulanate 2000/125 mg twice daily compared with conventional formulations and other marketed antimicrobials in the treatment of respiratory tract infection. ..
- Prasad R, Giri S, Nath N, Singh I, Singh A. GSNO attenuates EAE disease by S-nitrosylation-mediated modulation of endothelial-monocyte interactions. Glia. 2007;55:65-77 pubmed..These observations suggest that GSNO exerts its protective effects in EAE by inhibition of cellular infiltration into the CNS by S-nitrosylation of p65, thereby modulating NF-kappaB-CAMs pathway in endothelial cells. ..
- Chintalacharuvu S, Yamashita M, Bagheri N, Blanchard T, Nedrud J, Lamm M, et al. T cell cytokine polarity as a determinant of immunoglobulin A (IgA) glycosylation and the severity of experimental IgA nephropathy. Clin Exp Immunol. 2008;153:456-62 pubmed publisher..We conclude that the polarity of T cell cytokines controls the pattern of IgA glycosylation and exerts direct or indirect effects on functional glomerular responses to immune complex deposition. ..
- Hanna A, Horne P, Yager D, Eckman C, Eckman E, Janus C. Amyloid beta and impairment in multiple memory systems in older transgenic APP TgCRND8 mice. Genes Brain Behav. 2009;8:676-84 pubmed publisher..The lack of association between amyloid plaques and memory decline supports clinical findings in Alzheimer's patients. ..
- Sengupta N, Afzal A, Caballero S, Chang K, Shaw L, Pang J, et al. Paracrine modulation of CXCR4 by IGF-1 and VEGF: implications for choroidal neovascularization. Invest Ophthalmol Vis Sci. 2010;51:2697-704 pubmed publisher..The potent proangiogenic factors IGF-1 and VEGF both stimulate SDF-1-induced angiogenesis. Local inhibition of CXCR4 is required for an antiangiogenic effect in CNV lesions. ..
- Rink C, Roy S, Khan M, Ananth P, Kuppusamy P, Sen C, et al. Oxygen-sensitive outcomes and gene expression in acute ischemic stroke. J Cereb Blood Flow Metab. 2010;30:1275-87 pubmed publisher..The findings provide key information relevant to understanding oxygen-dependent molecular mechanisms in the AIS-affected brain. ..
- Pachner A, Amemiya K, Bartlett M, Schaefer H, Reddy K, Zhang W. Lyme borreliosis in rhesus macaques: effects of corticosteroids on spirochetal load and isotype switching of anti-borrelia burgdorferi antibody. Clin Diagn Lab Immunol. 2001;8:225-32 pubmed..burgdorferi IgG antibody is much more effective than IgM antibody in decreasing the spirochetal load in infected animals. ..
- Wildin R, Smyk Pearson S, Filipovich A. Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome. J Med Genet. 2002;39:537-45 pubmed..Remission has been observed with bone marrow transplantation despite incomplete engraftment, but the long term outcome is uncertain. ..
- Zhou Z, Penn M, Forudi F, Zhou X, Tarakji K, Topol E, et al. Administration of recombinant P-selectin glycoprotein ligand Fc fusion protein suppresses inflammation and neointimal formation in Zucker diabetic rat model. Arterioscler Thromb Vasc Biol. 2002;22:1598-603 pubmed
- Haigis K, Dove W. A Robertsonian translocation suppresses a somatic recombination pathway to loss of heterozygosity. Nat Genet. 2003;33:33-9 pubmed..These studies provide additional evidence that neoplastic growth can initiate in the complete absence of canonical genomic instability. ..
- Somera K, Jones H. Reduced subcommissural organ glycoprotein immunoreactivity precedes aqueduct closure and ventricular dilatation in H-Tx rat hydrocephalus. Cell Tissue Res. 2004;315:361-73 pubmed..Decreased nestin immunostaining accompanied the SCO changes. It is concluded that reduced SCO glycoprotein immunoreactivity precedes both aqueduct closure and expansion of the lateral ventricles in the H-Tx rat. ..
- Tannehill Gregg S, Kusewitt D, Rosol T, Weinstein M. The roles of Smad2 and Smad3 in the development of chemically induced skin tumors in mice. Vet Pathol. 2004;41:278-82 pubmed..There was a significant difference (P < 0.05) in tumor type between Smad2(+/-) and Smad3(+/-) groups, suggesting that Smad2 and Smad3 may regulate different targets. ..
- Weydt P, Yuen E, Ransom B, Moller T. Increased cytotoxic potential of microglia from ALS-transgenic mice. Glia. 2004;48:179-82 pubmed..Neonatal microglia, however, showed no differences. Our findings suggest an increased cytotoxic potential of adult mtSOD1 microglia, which only becomes apparent after microglial activation. ..
- Prince L, Okoh V, Moninger T, Matalon S. Lipopolysaccharide increases alveolar type II cell number in fetal mouse lungs through Toll-like receptor 4 and NF-kappaB. Am J Physiol Lung Cell Mol Physiol. 2004;287:L999-1006 pubmed..These data implicate an important signaling mechanism in chorioamnionitis and suggest the TLR4/NF-kappaB pathway can influence lung development. ..
- Stahl J. Using eye movements to assess brain function in mice. Vision Res. 2004;44:3401-10 pubmed..Here we introduce analytical tools used in ocular motor research and demonstrate their ability to reveal disorders of the visual pathways, inner ear, and cerebellum. ..
- Hoffman G. Determinants of vessel targeting in vasculitis. Clin Dev Immunol. 2004;11:275-9 pubmed..Studies of vascular diseases must assess how such variables may affect regional differences in endothelial cells, subendothelial matrix, vascular smooth muscle and the response of each to a variety of stimuli. ..
- Sun Z, Zhang Z. Historic perspectives and recent advances in major animal models of hypertension. Acta Pharmacol Sin. 2005;26:295-301 pubmed..In addition, the clinical implications of the above experimental models of hypertension are addressed. ..
- Zhou L, Askew D, Wu C, Gilliam A. Cutaneous gene expression by DNA microarray in murine sclerodermatous graft-versus-host disease, a model for human scleroderma. J Invest Dermatol. 2007;127:281-92 pubmed..They are useful to understand the pathogenesis of Scl GVHD, to identify markers for early diagnosis of disease, and to devise more effective strategies for intervention in early scleroderma and Scl GVHD. ..
- Kim H, Jin J, Maxwell J, Fukuchi K. Enhancing Th2 immune responses against amyloid protein by a DNA prime-adenovirus boost regimen for Alzheimer's disease. Immunol Lett. 2007;112:30-8 pubmed
- Xia M, Yang S, Simpkins J, Liu H. Noninvasive monitoring of estrogen effects against ischemic stroke in rats by near-infrared spectroscopy. Appl Opt. 2007;46:8315-21 pubmed..e., to detect focal cerebral ischemia and to monitor cerebral responses to therapy against vascular dysfunction in animal models. ..
- Jiang Q, Lee C, Mandrekar S, Wilkinson B, Cramer P, Zelcer N, et al. ApoE promotes the proteolytic degradation of Abeta. Neuron. 2008;58:681-93 pubmed publisher..GW3965 treatment also reversed contextual memory deficits. These data demonstrate a mechanism through which ApoE facilitates the clearance of Abeta from the brain and suggest that LXR agonists may represent a novel therapy for AD...
- Mu W, Long D, Ouyang X, Agarwal A, Cruz P, Roncal C, et al. Angiostatin overexpression is associated with an improvement in chronic kidney injury by an anti-inflammatory mechanism. Am J Physiol Renal Physiol. 2009;296:F145-52 pubmed publisher..However, its anti-angiogenic actions suggest countering effects that could partially offset its benefit in chronic kidney diseases. ..
- Meeran S, Akhtar S, Katiyar S. Inhibition of UVB-induced skin tumor development by drinking green tea polyphenols is mediated through DNA repair and subsequent inhibition of inflammation. J Invest Dermatol. 2009;129:1258-70 pubmed publisher..To our knowledge, it is previously unreported that prevention of photocarcinogenesis by GTPs is mediated through IL-12-dependent DNA repair and a subsequent reduction in skin inflammation. ..
- Rosenberg D, Giardina C, Tanaka T. Mouse models for the study of colon carcinogenesis. Carcinogenesis. 2009;30:183-96 pubmed publisher..We will also describe the general features of lesions formed in response to carcinogen treatment, including the underlying molecular aberrations and how these changes may relate to the pathogenesis of human colorectal cancer. ..
- Park S, Wankhede M, Lee Y, Choi E, Fliess N, Choe S, et al. Real-time imaging of de novo arteriovenous malformation in a mouse model of hereditary hemorrhagic telangiectasia. J Clin Invest. 2009;119:3487-96 pubmed publisher..We believe our data provide novel insights into the pathogenetic mechanisms of HHT and potential therapeutic approaches. ..
- Hanson K, Kim S, Wassarman D, Tibbetts R. Ubiquilin modifies TDP-43 toxicity in a Drosophila model of amyotrophic lateral sclerosis (ALS). J Biol Chem. 2010;285:11068-72 pubmed publisher..Our findings demonstrate that TDP-43 exerts cell-autonomous neurotoxicity in Drosophila and further imply that dose-dependent alterations of TDP-43 nuclear function may underlie motor neuron death in ALS. ..
- Yang Y, Liu Y, Wei P, Peng H, Winger R, Hussain R, et al. Silencing Nogo-A promotes functional recovery in demyelinating disease. Ann Neurol. 2010;67:498-507 pubmed publisher..Silencing Nogo-A may be a therapeutic option for MS patients to prevent permanent functional deficits caused by immune-mediated axonal damage. ..
- Bhattacharjee A, Mishra R, Feldman G, Cathcart M. In vivo validation of signaling pathways regulating human monocyte chemotaxis. J Immunol Methods. 2008;330:86-95 pubmed publisher..Validation of relevant regulatory molecules in vivo is critical for understanding the most relevant therapeutic targets for drug development. ..
- Manhiani M, Quigley J, Knight S, Tasoobshirazi S, Moore T, Brands M, et al. Soluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertension. Am J Physiol Renal Physiol. 2009;297:F740-8 pubmed publisher..These data demonstrate that Ephx2 gene deletion decreases blood pressure, attenuates renal inflammation, and ameliorates glomerular injury in DOCA-salt hypertension. ..
- Rodriguez M, Oleszak E, Leibowitz J. Theiler's murine encephalomyelitis: a model of demyelination and persistence of virus. Crit Rev Immunol. 1987;7:325-65 pubmed
- Jacoby R, Hohman C, Marshall D, Frick T, Schlack S, Broda M, et al. Genetic analysis of colon cancer susceptibility in mice. Genomics. 1994;22:381-7 pubmed..Multiple loci contribute to the phenotype, with significant linkage to a novel locus, Ccs1, between D12Mit5 and D12Mit6 on mouse Chr 12. Comparative maps suggest that the human homologue of Ccs1 is near FOS on human chromosome 14q. ..
- Swartz K, Liu F, Sewell D, Schochet T, Campbell I, Sandor M, et al. Interleukin-6 promotes post-traumatic healing in the central nervous system. Brain Res. 2001;896:86-95 pubmed..Combined, this data suggests an important role of IL-6 in tissue repair processes following traumatic injury in the CNS. ..
- Ryomoto M, Wolff R, Tomas J, Miyamoto T, Hoch J. 17 beta-estradiol attenuates intimal hyperplasia and macrophage accumulation with a reduction in monocyte chemoattractant protein 1 expression in a vein graft model. J Vasc Surg. 2002;36:613-21 pubmed..E(2) treatment reduces vein-graft intimal hyperplasia coincident with a reduction in MCP-1 expression, macrophage accumulation, and cell proliferation. ..
- Miller M, Haxhiu M, Georgiadis P, Gudz T, Kangas C, Macklin W. Proteolipid protein gene mutation induces altered ventilatory response to hypoxia in the myelin-deficient rat. J Neurosci. 2003;23:2265-73 pubmed
- Wu L, Gu J, Weng Y, Kluetzman K, Swiatek P, Behr M, et al. Conditional knockout of the mouse NADPH-cytochrome p450 reductase gene. Genesis. 2003;36:177-81 pubmed
- Singh D, Griffin D, Pacyniak E, Jackson M, Werle M, Wisdom B, et al. The presence of the casein kinase II phosphorylation sites of Vpu enhances the CD4(+) T cell loss caused by the simian-human immunodeficiency virus SHIV(KU-lbMC33) in pig-tailed macaques. Virology. 2003;313:435-51 pubmed
- Kanadia R, Johnstone K, Mankodi A, Lungu C, Thornton C, Esson D, et al. A muscleblind knockout model for myotonic dystrophy. Science. 2003;302:1978-80 pubmed..Our results support the hypothesis that manifestations of DM can result from sequestration of specific RNA binding proteins by a repetitive element expansion in a mutant RNA. ..
- Korcheva V, Wong J, Corless C, Iordanov M, Magun B. Administration of ricin induces a severe inflammatory response via nonredundant stimulation of ERK, JNK, and P38 MAPK and provides a mouse model of hemolytic uremic syndrome. Am J Pathol. 2005;166:323-39 pubmed..Therapeutic management of the inflammatory response may affect the outcome of intoxication by ricin. ..
- Ha T, Li Y, Gao X, McMullen J, Shioi T, Izumo S, et al. Attenuation of cardiac hypertrophy by inhibiting both mTOR and NFkappaB activation in vivo. Free Radic Biol Med. 2005;39:1570-80 pubmed..Similar results were observed in aortic-banding-induced cardiac hypertrophy in mice. Our results suggest that both NFkappaB activation and the PI3K/Akt signaling pathway participate in the development of cardiac hypertrophy in vivo. ..
- Gosselin L, Williams J, Personius K, Farkas G. A comparison of factors associated with collagen metabolism in different skeletal muscles from dystrophic (mdx) mice: impact of pirfenidone. Muscle Nerve. 2007;35:208-16 pubmed..Moreover, the pharmacological use of pirfenidone may be beneficial in preventing fibrosis in muscular dystrophy. ..
- Forte M, Gold B, Marracci G, Chaudhary P, Basso E, Johnsen D, et al. Cyclophilin D inactivation protects axons in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. Proc Natl Acad Sci U S A. 2007;104:7558-63 pubmed..Our results directly implicate pathological activation of the mitochondrial PTP in the axonal damage occurring during MS and identify CyPD, as well as the PTP, as a potential target for MS neuroprotective therapies. ..
- Seo H, Kim W, Isacson O. Compensatory changes in the ubiquitin-proteasome system, brain-derived neurotrophic factor and mitochondrial complex II/III in YAC72 and R6/2 transgenic mice partially model Huntington's disease patients. Hum Mol Genet. 2008;17:3144-53 pubmed publisher..Changes in HD patients for UPS function, BDNF expression and MCII/III activity are only partially modeled in R6/2 and YAC72 mice, with the latter at 16 months of age being most congruent with the human disease. ..
- Gilbert J, Gilbert S, Arany M, Granger J. Hypertension produced by placental ischemia in pregnant rats is associated with increased soluble endoglin expression. Hypertension. 2009;53:399-403 pubmed publisher..The present study provides further evidence that placental ischemia is a strong in vivo stimulus of angiostatic factors during pregnancy. ..
- Kwon Y, Lipatov A, Swayne D. Bronchointerstitial pneumonia in guinea pigs following inoculation with H5N1 high pathogenicity avian influenza virus. Vet Pathol. 2009;46:138-41 pubmed publisher..The localized respiratory disease in guinea pigs with H5N1 viruses was very similar to that of H3N2 and H1N1 influenza in humans and was less severe than reported for H5N1 human cases. ..
- Boyanovsky B, Zack M, Forrest K, Webb N. The capacity of group V sPLA2 to increase atherogenicity of ApoE-/- and LDLR-/- mouse LDL in vitro predicts its atherogenic role in vivo. Arterioscler Thromb Vasc Biol. 2009;29:532-8 pubmed publisher..The ability of GV sPLA(2) to promote atherosclerotic lipid deposition in apoE(-/-) and LDLR(-/-) mice may be related to its ability to increase the atherogenic potential of LDL from these mice as assessed in vitro. ..
- Schaub C, Wood C. Blockade of estrogen action upregulates estrogen receptor-alpha mRNA in the fetal brain. Neonatology. 2009;96:115-9 pubmed publisher..There were no changes in ER-alpha protein and no changes in ER-beta at either the mRNA or protein level. Expression of ER-alpha is influenced by endogenous estrogens in the ovine fetal brain. ..
- Lin S, Fan L, Rhodes P, Cai Z. Intranasal administration of IGF-1 attenuates hypoxic-ischemic brain injury in neonatal rats. Exp Neurol. 2009;217:361-70 pubmed publisher..rhIGF-1 enhanced proliferation of neuronal and oligodendroglial progenitors after cerebral HI as well. These data suggest that iN administration of IGF-1 has the potential to be used for clinical treatment. ..
- West G, Golshani K, Doyle K, Lessov N, Hobbs T, Kohama S, et al. A new model of cortical stroke in the rhesus macaque. J Cereb Blood Flow Metab. 2009;29:1175-86 pubmed publisher..This approach offers promise for evaluating therapeutic interventions in stroke. ..
- Takeda A, Baffi J, Kleinman M, Cho W, Nozaki M, Yamada K, et al. CCR3 is a target for age-related macular degeneration diagnosis and therapy. Nature. 2009;460:225-30 pubmed publisher..CCR3 targeting might reduce vision loss due to AMD through early detection and therapeutic angioinhibition. ..
- De Lisle R, Sewell R, Meldi L. Enteric circular muscle dysfunction in the cystic fibrosis mouse small intestine. Neurogastroenterol Motil. 2010;22:341-e87 pubmed publisher..CONCLUSIONS & INFERENCES These results suggest that the enteric microbiota modulates PGE(2) levels in a complex manner, which affects enteric smooth muscle activity and contributes to slower small intestinal transit in CF...
- Chance M, Chang J, Liu S, Gokulrangan G, Chen D, Lindsay A, et al. Proteomics, bioinformatics and targeted gene expression analysis reveals up-regulation of cochlin and identifies other potential biomarkers in the mouse model for deafness in Usher syndrome type 1F. Hum Mol Genet. 2010;19:1515-27 pubmed publisher..Our report strongly suggests that increased level of cochlin is an important etiologic factor leading to the degeneration of cochlear neuroepithelia in the USH1F model. ..
- Li F, Cheng Q, Ling X, Stablewski A, Tang L, Foster B, et al. Generation of a novel transgenic mouse model for bioluminescent monitoring of survivin gene activity in vivo at various pathophysiological processes: survivin expression overlaps with stem cell markers. Am J Pathol. 2010;176:1629-38 pubmed publisher..Thus, we have generated a unique animal model for analysis of diverse pathophysiological processes and possible stem cell distribution/activity in vivo. ..
- Morel L. Genetics of SLE: evidence from mouse models. Nat Rev Rheumatol. 2010;6:348-57 pubmed publisher..Consequently, mouse models will continue to serve a pre-eminent role in lupus genetics research, with an increased emphasis on mechanistic and molecular studies of human susceptibility alleles. ..
- Venegas Pont M, Manigrasso M, Grifoni S, LaMarca B, Maric C, Racusen L, et al. Tumor necrosis factor-alpha antagonist etanercept decreases blood pressure and protects the kidney in a mouse model of systemic lupus erythematosus. Hypertension. 2010;56:643-9 pubmed publisher..These data suggest that TNF-? mechanistically contributes to the development of hypertension in a chronic inflammatory disease through increased renal nuclear factor ?B, oxidative stress, and inflammation. ..
- Holdener B, Magnuson T. A mouse model for human hereditary tyrosinemia I. Bioessays. 1994;16:85-7 pubmed
- Li B, Murphy K, Laucirica R, Kittrell F, Medina D, Rosen J. A transgenic mouse model for mammary carcinogenesis. Oncogene. 1998;16:997-1007 pubmed..It may also be used as a preclinical model to test newly developed chemotherapeutic strategies. ..
- Hutton M, Lewis J, Dickson D, Yen S, McGowan E. Analysis of tauopathies with transgenic mice. Trends Mol Med. 2001;7:467-70 pubmed..Recent progress in the development of transgenic mouse models of human tauopathy is allowing these questions to be addressed. ..
- Johnson D, Klaassen C. Role of rat multidrug resistance protein 2 in plasma and biliary disposition of dibromosulfophthalein after microsomal enzyme induction. Toxicol Appl Pharmacol. 2002;180:56-63 pubmed..This study also demonstrates the importance of compensatory hepatic transporters in eliminating DBSP by alternative pathways other than Mrp2. ..
- Pavelko K, Howe C, Drescher K, Gamez J, Johnson A, Wei T, et al. Interleukin-6 protects anterior horn neurons from lethal virus-induced injury. J Neurosci. 2003;23:481-92 pubmed..These data support the hypothesis that IL-6 plays a critical role in protecting specific populations of neurons from irreversible injury. ..
- Marks D, Butler A, Turner R, Brookhart G, Cone R. Differential role of melanocortin receptor subtypes in cachexia. Endocrinology. 2003;144:1513-23 pubmed..These data underscore the importance of central melanocortin signaling in weight homeostasis and demonstrate differential effects of MC3-R and MC4-R blockade on the development of cachexia. ..
- Plautz E, Barbay S, Frost S, Friel K, Dancause N, Zoubina E, et al. Post-infarct cortical plasticity and behavioral recovery using concurrent cortical stimulation and rehabilitative training: a feasibility study in primates. Neurol Res. 2003;25:801-10 pubmed..Results support the feasibility of using a therapy approach combining peri-infarct electrical stimulation with rehabilitative training to alleviate chronic motor deficits and promote recovery from cortical ischemic injury. ..
- Hsu H, Tawfik O, Sun F. Mechanism of dystrophic calcification in rabbit aortas: temporal and spatial distributions of calcifying vesicles and calcification-related structural proteins. Cardiovasc Pathol. 2004;13:3-10 pubmed..The coordinated changes in the accumulation of collagen, disintegration of internal elastic fibers, and the appearance of calcifying vesicles in the lesions before calcification may set the stage for aortic calcification. ..
- Li W, Rusiniak M, Chintala S, Gautam R, Novak E, Swank R. Murine Hermansky-Pudlak syndrome genes: regulators of lysosome-related organelles. Bioessays. 2004;26:616-28 pubmed..Studies of the molecular functions of HPS proteins will reveal important details of vesicle trafficking and may lead to therapies for HPS...
- Olds M, Jacques D, Kopyov O. Behavioral and anatomical effects of quinolinic acid in the striatum of the hemiparkinsonian rat. Synapse. 2005;55:26-36 pubmed
- Sarkar A, Hall M, Exline M, Hart J, Knatz N, Gatson N, et al. Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1beta and interleukin-18. Am J Respir Crit Care Med. 2006;174:1003-10 pubmed..Taken together, these findings suggest that caspase-1 is important in the host response to sepsis at least in part via its ability to regulate sepsis-induced splenic cell apoptosis. ..
- Aikman J, O Steen B, Silver X, Torres R, Boslaugh S, Blackband S, et al. Alpha-II-spectrin after controlled cortical impact in the immature rat brain. Dev Neurosci. 2006;28:457-65 pubmed..Distinct proteolytic products resulting from the degradation of the cytoskeletal protein alpha-II-spectrin by calpain and caspase 3 were readily detectable in cortical brain parenchyma and cerebrospinal fluid after TBI in immature rats. ..
- Schwendt M, Hearing M, See R, McGinty J. Chronic cocaine reduces RGS4 mRNA in rat prefrontal cortex and dorsal striatum. Neuroreport. 2007;18:1261-5 pubmed..Changes in RGS4 mRNA levels might signal abnormal receptor G-protein coupling that impacts cocaine seeking. ..
- Pantano C, Ather J, Alcorn J, Poynter M, Brown A, Guala A, et al. Nuclear factor-kappaB activation in airway epithelium induces inflammation and hyperresponsiveness. Am J Respir Crit Care Med. 2008;177:959-69 pubmed publisher..These findings demonstrate that selective activation NF-kappaB in airway epithelium is sufficient to induce airway hyperresponsiveness and smooth muscle thickening, which are both critical features of allergic airway disease. ..
- Kostyk S, Popovich P, Stokes B, Wei P, Jakeman L. Robust axonal growth and a blunted macrophage response are associated with impaired functional recovery after spinal cord injury in the MRL/MpJ mouse. Neuroscience. 2008;156:498-514 pubmed publisher..However, this response occurs at the expense of meaningful functional recovery. ..
- Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn M, et al. apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J Clin Invest. 2008;118:4002-13 pubmed publisher..Thus, apoE isoforms differentially regulate Abeta clearance from the brain, and this might contribute to the effects of APOE genotype on the disease process in both individuals with AD and animal models of AD. ..
- Hong J, Lebofsky M, Farhood A, Jaeschke H. Oxidant stress-induced liver injury in vivo: role of apoptosis, oncotic necrosis, and c-Jun NH2-terminal kinase activation. Am J Physiol Gastrointest Liver Physiol. 2009;296:G572-81 pubmed publisher..The data indicate that liver cell death initiated by diquat-induced superoxide formation in vivo is mediated predominantly by oncotic necrosis and is independent of JNK activation. ..
- Rohrer B, Long Q, Coughlin B, Wilson R, Huang Y, Qiao F, et al. A targeted inhibitor of the alternative complement pathway reduces angiogenesis in a mouse model of age-related macular degeneration. Invest Ophthalmol Vis Sci. 2009;50:3056-64 pubmed publisher..The most common AMD-associated variant of fH resides within a native cell-binding region of fH (Tyr402His). These data may open new avenues for AMD treatment strategies. ..
- Vera T, Granger J, Stec D. Inhibition of bilirubin metabolism induces moderate hyperbilirubinemia and attenuates ANG II-dependent hypertension in mice. Am J Physiol Regul Integr Comp Physiol. 2009;297:R738-43 pubmed publisher..These results indicate that moderate hyperbilirubinemia prevents ANG II-dependent hypertension by a mechanism that may involve decreases in vascular oxidative stress. ..
- Ritchlin C, Proulx S, Schwarz E. Translational perspectives on psoriatic arthritis. J Rheumatol Suppl. 2009;83:30-4 pubmed publisher..These translational studies point to potential biomarkers of arthritis in psoriasis patients and generate alternative hypotheses to explain the events that lead to arthritic flare...
- LaMarca B, Parrish M, Ray L, Murphy S, Roberts L, Glover P, et al. Hypertension in response to autoantibodies to the angiotensin II type I receptor (AT1-AA) in pregnant rats: role of endothelin-1. Hypertension. 2009;54:905-9 pubmed publisher..Collectively, these data support the hypothesis that one potential pathway whereby AT1-AAs increase blood pressure during pregnancy is by an ET-1-dependent mechanism. ..
- DeRuisseau L, Recca D, Mogle J, Zoccolillo M, DeRuisseau K. Metallothionein deficiency leads to soleus muscle contractile dysfunction following acute spinal cord injury in mice. Am J Physiol Regul Integr Comp Physiol. 2009;297:R1795-802 pubmed publisher..These findings suggest a role of MT in mediating protective adaptations in skeletal muscle following disuse mediated by spinal cord injury. ..
- Paquette M, Anderson A, Lewis J, Meshul C, Johnson S, Paul Berger S. MK-801 inhibits L-DOPA-induced abnormal involuntary movements only at doses that worsen parkinsonism. Neuropharmacology. 2010;58:1002-8 pubmed publisher..We conclude that noncompetitive NMDA antagonists are unlikely to suppress dyskinesia clinically without worsening parkinsonism. ..
- PAULK N, Wursthorn K, Wang Z, Finegold M, Kay M, Grompe M. Adeno-associated virus gene repair corrects a mouse model of hereditary tyrosinemia in vivo. Hepatology. 2010;51:1200-8 pubmed publisher..In this model, repaired hepatocytes have a selective growth advantage and are thus able to proliferate to efficiently repopulate mutant livers and cure the underlying metabolic disease...