Experts and Doctors on animal disease models in United States


Locale: United States
Topic: animal disease models

Top Publications

  1. Bhattacharjee A, Mishra R, Feldman G, Cathcart M. In vivo validation of signaling pathways regulating human monocyte chemotaxis. J Immunol Methods. 2008;330:86-95 pubmed publisher
    ..Validation of relevant regulatory molecules in vivo is critical for understanding the most relevant therapeutic targets for drug development. ..
  2. Manhiani M, Quigley J, Knight S, Tasoobshirazi S, Moore T, Brands M, et al. Soluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertension. Am J Physiol Renal Physiol. 2009;297:F740-8 pubmed publisher
    ..These data demonstrate that Ephx2 gene deletion decreases blood pressure, attenuates renal inflammation, and ameliorates glomerular injury in DOCA-salt hypertension. ..
  3. Rodriguez M, Oleszak E, Leibowitz J. Theiler's murine encephalomyelitis: a model of demyelination and persistence of virus. Crit Rev Immunol. 1987;7:325-65 pubmed
  4. Jacoby R, Hohman C, Marshall D, Frick T, Schlack S, Broda M, et al. Genetic analysis of colon cancer susceptibility in mice. Genomics. 1994;22:381-7 pubmed
    ..Multiple loci contribute to the phenotype, with significant linkage to a novel locus, Ccs1, between D12Mit5 and D12Mit6 on mouse Chr 12. Comparative maps suggest that the human homologue of Ccs1 is near FOS on human chromosome 14q. ..
  5. Swartz K, Liu F, Sewell D, Schochet T, Campbell I, Sandor M, et al. Interleukin-6 promotes post-traumatic healing in the central nervous system. Brain Res. 2001;896:86-95 pubmed
    ..Combined, this data suggests an important role of IL-6 in tissue repair processes following traumatic injury in the CNS. ..
  6. Ryomoto M, Wolff R, Tomas J, Miyamoto T, Hoch J. 17 beta-estradiol attenuates intimal hyperplasia and macrophage accumulation with a reduction in monocyte chemoattractant protein 1 expression in a vein graft model. J Vasc Surg. 2002;36:613-21 pubmed
    ..E(2) treatment reduces vein-graft intimal hyperplasia coincident with a reduction in MCP-1 expression, macrophage accumulation, and cell proliferation. ..
  7. Miller M, Haxhiu M, Georgiadis P, Gudz T, Kangas C, Macklin W. Proteolipid protein gene mutation induces altered ventilatory response to hypoxia in the myelin-deficient rat. J Neurosci. 2003;23:2265-73 pubmed
  8. Wu L, Gu J, Weng Y, Kluetzman K, Swiatek P, Behr M, et al. Conditional knockout of the mouse NADPH-cytochrome p450 reductase gene. Genesis. 2003;36:177-81 pubmed
  9. Singh D, Griffin D, Pacyniak E, Jackson M, Werle M, Wisdom B, et al. The presence of the casein kinase II phosphorylation sites of Vpu enhances the CD4(+) T cell loss caused by the simian-human immunodeficiency virus SHIV(KU-lbMC33) in pig-tailed macaques. Virology. 2003;313:435-51 pubmed

More Information

Publications438 found, 100 shown here

  1. Kanadia R, Johnstone K, Mankodi A, Lungu C, Thornton C, Esson D, et al. A muscleblind knockout model for myotonic dystrophy. Science. 2003;302:1978-80 pubmed
    ..Our results support the hypothesis that manifestations of DM can result from sequestration of specific RNA binding proteins by a repetitive element expansion in a mutant RNA. ..
  2. Korcheva V, Wong J, Corless C, Iordanov M, Magun B. Administration of ricin induces a severe inflammatory response via nonredundant stimulation of ERK, JNK, and P38 MAPK and provides a mouse model of hemolytic uremic syndrome. Am J Pathol. 2005;166:323-39 pubmed
    ..Therapeutic management of the inflammatory response may affect the outcome of intoxication by ricin. ..
  3. Ha T, Li Y, Gao X, McMullen J, Shioi T, Izumo S, et al. Attenuation of cardiac hypertrophy by inhibiting both mTOR and NFkappaB activation in vivo. Free Radic Biol Med. 2005;39:1570-80 pubmed
    ..Similar results were observed in aortic-banding-induced cardiac hypertrophy in mice. Our results suggest that both NFkappaB activation and the PI3K/Akt signaling pathway participate in the development of cardiac hypertrophy in vivo. ..
  4. Gosselin L, Williams J, Personius K, Farkas G. A comparison of factors associated with collagen metabolism in different skeletal muscles from dystrophic (mdx) mice: impact of pirfenidone. Muscle Nerve. 2007;35:208-16 pubmed
    ..Moreover, the pharmacological use of pirfenidone may be beneficial in preventing fibrosis in muscular dystrophy. ..
  5. Forte M, Gold B, Marracci G, Chaudhary P, Basso E, Johnsen D, et al. Cyclophilin D inactivation protects axons in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. Proc Natl Acad Sci U S A. 2007;104:7558-63 pubmed
    ..Our results directly implicate pathological activation of the mitochondrial PTP in the axonal damage occurring during MS and identify CyPD, as well as the PTP, as a potential target for MS neuroprotective therapies. ..
  6. Seo H, Kim W, Isacson O. Compensatory changes in the ubiquitin-proteasome system, brain-derived neurotrophic factor and mitochondrial complex II/III in YAC72 and R6/2 transgenic mice partially model Huntington's disease patients. Hum Mol Genet. 2008;17:3144-53 pubmed publisher
    ..Changes in HD patients for UPS function, BDNF expression and MCII/III activity are only partially modeled in R6/2 and YAC72 mice, with the latter at 16 months of age being most congruent with the human disease. ..
  7. Gilbert J, Gilbert S, Arany M, Granger J. Hypertension produced by placental ischemia in pregnant rats is associated with increased soluble endoglin expression. Hypertension. 2009;53:399-403 pubmed publisher
    ..The present study provides further evidence that placental ischemia is a strong in vivo stimulus of angiostatic factors during pregnancy. ..
  8. Kwon Y, Lipatov A, Swayne D. Bronchointerstitial pneumonia in guinea pigs following inoculation with H5N1 high pathogenicity avian influenza virus. Vet Pathol. 2009;46:138-41 pubmed publisher
    ..The localized respiratory disease in guinea pigs with H5N1 viruses was very similar to that of H3N2 and H1N1 influenza in humans and was less severe than reported for H5N1 human cases. ..
  9. Boyanovsky B, Zack M, Forrest K, Webb N. The capacity of group V sPLA2 to increase atherogenicity of ApoE-/- and LDLR-/- mouse LDL in vitro predicts its atherogenic role in vivo. Arterioscler Thromb Vasc Biol. 2009;29:532-8 pubmed publisher
    ..The ability of GV sPLA(2) to promote atherosclerotic lipid deposition in apoE(-/-) and LDLR(-/-) mice may be related to its ability to increase the atherogenic potential of LDL from these mice as assessed in vitro. ..
  10. Schaub C, Wood C. Blockade of estrogen action upregulates estrogen receptor-alpha mRNA in the fetal brain. Neonatology. 2009;96:115-9 pubmed publisher
    ..There were no changes in ER-alpha protein and no changes in ER-beta at either the mRNA or protein level. Expression of ER-alpha is influenced by endogenous estrogens in the ovine fetal brain. ..
  11. Lin S, Fan L, Rhodes P, Cai Z. Intranasal administration of IGF-1 attenuates hypoxic-ischemic brain injury in neonatal rats. Exp Neurol. 2009;217:361-70 pubmed publisher
    ..rhIGF-1 enhanced proliferation of neuronal and oligodendroglial progenitors after cerebral HI as well. These data suggest that iN administration of IGF-1 has the potential to be used for clinical treatment. ..
  12. West G, Golshani K, Doyle K, Lessov N, Hobbs T, Kohama S, et al. A new model of cortical stroke in the rhesus macaque. J Cereb Blood Flow Metab. 2009;29:1175-86 pubmed publisher
    ..This approach offers promise for evaluating therapeutic interventions in stroke. ..
  13. Takeda A, Baffi J, Kleinman M, Cho W, Nozaki M, Yamada K, et al. CCR3 is a target for age-related macular degeneration diagnosis and therapy. Nature. 2009;460:225-30 pubmed publisher
    ..CCR3 targeting might reduce vision loss due to AMD through early detection and therapeutic angioinhibition. ..
  14. De Lisle R, Sewell R, Meldi L. Enteric circular muscle dysfunction in the cystic fibrosis mouse small intestine. Neurogastroenterol Motil. 2010;22:341-e87 pubmed publisher
    ..CONCLUSIONS & INFERENCES These results suggest that the enteric microbiota modulates PGE(2) levels in a complex manner, which affects enteric smooth muscle activity and contributes to slower small intestinal transit in CF...
  15. Chance M, Chang J, Liu S, Gokulrangan G, Chen D, Lindsay A, et al. Proteomics, bioinformatics and targeted gene expression analysis reveals up-regulation of cochlin and identifies other potential biomarkers in the mouse model for deafness in Usher syndrome type 1F. Hum Mol Genet. 2010;19:1515-27 pubmed publisher
    ..Our report strongly suggests that increased level of cochlin is an important etiologic factor leading to the degeneration of cochlear neuroepithelia in the USH1F model. ..
  16. Li F, Cheng Q, Ling X, Stablewski A, Tang L, Foster B, et al. Generation of a novel transgenic mouse model for bioluminescent monitoring of survivin gene activity in vivo at various pathophysiological processes: survivin expression overlaps with stem cell markers. Am J Pathol. 2010;176:1629-38 pubmed publisher
    ..Thus, we have generated a unique animal model for analysis of diverse pathophysiological processes and possible stem cell distribution/activity in vivo. ..
  17. Adamus G, Karren L, Mooney J, Burrows G. A promising therapeutic approach for treatment of posterior uveitis: recombinant T cell receptor ligand protects Lewis rats from acute and recurrent experimental autoimmune uveitis. Ophthalmic Res. 2010;44:24-33 pubmed publisher
  18. Morel L. Genetics of SLE: evidence from mouse models. Nat Rev Rheumatol. 2010;6:348-57 pubmed publisher
    ..Consequently, mouse models will continue to serve a pre-eminent role in lupus genetics research, with an increased emphasis on mechanistic and molecular studies of human susceptibility alleles. ..
  19. Venegas Pont M, Manigrasso M, Grifoni S, LaMarca B, Maric C, Racusen L, et al. Tumor necrosis factor-alpha antagonist etanercept decreases blood pressure and protects the kidney in a mouse model of systemic lupus erythematosus. Hypertension. 2010;56:643-9 pubmed publisher
    ..These data suggest that TNF-? mechanistically contributes to the development of hypertension in a chronic inflammatory disease through increased renal nuclear factor ?B, oxidative stress, and inflammation. ..
  20. Holdener B, Magnuson T. A mouse model for human hereditary tyrosinemia I. Bioessays. 1994;16:85-7 pubmed
  21. Li B, Murphy K, Laucirica R, Kittrell F, Medina D, Rosen J. A transgenic mouse model for mammary carcinogenesis. Oncogene. 1998;16:997-1007 pubmed
    ..It may also be used as a preclinical model to test newly developed chemotherapeutic strategies. ..
  22. Hutton M, Lewis J, Dickson D, Yen S, McGowan E. Analysis of tauopathies with transgenic mice. Trends Mol Med. 2001;7:467-70 pubmed
    ..Recent progress in the development of transgenic mouse models of human tauopathy is allowing these questions to be addressed. ..
  23. Johnson D, Klaassen C. Role of rat multidrug resistance protein 2 in plasma and biliary disposition of dibromosulfophthalein after microsomal enzyme induction. Toxicol Appl Pharmacol. 2002;180:56-63 pubmed
    ..This study also demonstrates the importance of compensatory hepatic transporters in eliminating DBSP by alternative pathways other than Mrp2. ..
  24. Pavelko K, Howe C, Drescher K, Gamez J, Johnson A, Wei T, et al. Interleukin-6 protects anterior horn neurons from lethal virus-induced injury. J Neurosci. 2003;23:481-92 pubmed
    ..These data support the hypothesis that IL-6 plays a critical role in protecting specific populations of neurons from irreversible injury. ..
  25. Marks D, Butler A, Turner R, Brookhart G, Cone R. Differential role of melanocortin receptor subtypes in cachexia. Endocrinology. 2003;144:1513-23 pubmed
    ..These data underscore the importance of central melanocortin signaling in weight homeostasis and demonstrate differential effects of MC3-R and MC4-R blockade on the development of cachexia. ..
  26. Plautz E, Barbay S, Frost S, Friel K, Dancause N, Zoubina E, et al. Post-infarct cortical plasticity and behavioral recovery using concurrent cortical stimulation and rehabilitative training: a feasibility study in primates. Neurol Res. 2003;25:801-10 pubmed
    ..Results support the feasibility of using a therapy approach combining peri-infarct electrical stimulation with rehabilitative training to alleviate chronic motor deficits and promote recovery from cortical ischemic injury. ..
  27. Hsu H, Tawfik O, Sun F. Mechanism of dystrophic calcification in rabbit aortas: temporal and spatial distributions of calcifying vesicles and calcification-related structural proteins. Cardiovasc Pathol. 2004;13:3-10 pubmed
    ..The coordinated changes in the accumulation of collagen, disintegration of internal elastic fibers, and the appearance of calcifying vesicles in the lesions before calcification may set the stage for aortic calcification. ..
  28. Li W, Rusiniak M, Chintala S, Gautam R, Novak E, Swank R. Murine Hermansky-Pudlak syndrome genes: regulators of lysosome-related organelles. Bioessays. 2004;26:616-28 pubmed
    ..Studies of the molecular functions of HPS proteins will reveal important details of vesicle trafficking and may lead to therapies for HPS...
  29. Olds M, Jacques D, Kopyov O. Behavioral and anatomical effects of quinolinic acid in the striatum of the hemiparkinsonian rat. Synapse. 2005;55:26-36 pubmed
  30. Sarkar A, Hall M, Exline M, Hart J, Knatz N, Gatson N, et al. Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1beta and interleukin-18. Am J Respir Crit Care Med. 2006;174:1003-10 pubmed
    ..Taken together, these findings suggest that caspase-1 is important in the host response to sepsis at least in part via its ability to regulate sepsis-induced splenic cell apoptosis. ..
  31. Aikman J, O Steen B, Silver X, Torres R, Boslaugh S, Blackband S, et al. Alpha-II-spectrin after controlled cortical impact in the immature rat brain. Dev Neurosci. 2006;28:457-65 pubmed
    ..Distinct proteolytic products resulting from the degradation of the cytoskeletal protein alpha-II-spectrin by calpain and caspase 3 were readily detectable in cortical brain parenchyma and cerebrospinal fluid after TBI in immature rats. ..
  32. Schwendt M, Hearing M, See R, McGinty J. Chronic cocaine reduces RGS4 mRNA in rat prefrontal cortex and dorsal striatum. Neuroreport. 2007;18:1261-5 pubmed
    ..Changes in RGS4 mRNA levels might signal abnormal receptor G-protein coupling that impacts cocaine seeking. ..
  33. Pantano C, Ather J, Alcorn J, Poynter M, Brown A, Guala A, et al. Nuclear factor-kappaB activation in airway epithelium induces inflammation and hyperresponsiveness. Am J Respir Crit Care Med. 2008;177:959-69 pubmed publisher
    ..These findings demonstrate that selective activation NF-kappaB in airway epithelium is sufficient to induce airway hyperresponsiveness and smooth muscle thickening, which are both critical features of allergic airway disease. ..
  34. Kostyk S, Popovich P, Stokes B, Wei P, Jakeman L. Robust axonal growth and a blunted macrophage response are associated with impaired functional recovery after spinal cord injury in the MRL/MpJ mouse. Neuroscience. 2008;156:498-514 pubmed publisher
    ..However, this response occurs at the expense of meaningful functional recovery. ..
  35. Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn M, et al. apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J Clin Invest. 2008;118:4002-13 pubmed publisher
    ..Thus, apoE isoforms differentially regulate Abeta clearance from the brain, and this might contribute to the effects of APOE genotype on the disease process in both individuals with AD and animal models of AD. ..
  36. Hong J, Lebofsky M, Farhood A, Jaeschke H. Oxidant stress-induced liver injury in vivo: role of apoptosis, oncotic necrosis, and c-Jun NH2-terminal kinase activation. Am J Physiol Gastrointest Liver Physiol. 2009;296:G572-81 pubmed publisher
    ..The data indicate that liver cell death initiated by diquat-induced superoxide formation in vivo is mediated predominantly by oncotic necrosis and is independent of JNK activation. ..
  37. Rohrer B, Long Q, Coughlin B, Wilson R, Huang Y, Qiao F, et al. A targeted inhibitor of the alternative complement pathway reduces angiogenesis in a mouse model of age-related macular degeneration. Invest Ophthalmol Vis Sci. 2009;50:3056-64 pubmed publisher
    ..The most common AMD-associated variant of fH resides within a native cell-binding region of fH (Tyr402His). These data may open new avenues for AMD treatment strategies. ..
  38. Vera T, Granger J, Stec D. Inhibition of bilirubin metabolism induces moderate hyperbilirubinemia and attenuates ANG II-dependent hypertension in mice. Am J Physiol Regul Integr Comp Physiol. 2009;297:R738-43 pubmed publisher
    ..These results indicate that moderate hyperbilirubinemia prevents ANG II-dependent hypertension by a mechanism that may involve decreases in vascular oxidative stress. ..
  39. Ritchlin C, Proulx S, Schwarz E. Translational perspectives on psoriatic arthritis. J Rheumatol Suppl. 2009;83:30-4 pubmed publisher
    ..These translational studies point to potential biomarkers of arthritis in psoriasis patients and generate alternative hypotheses to explain the events that lead to arthritic flare...
  40. LaMarca B, Parrish M, Ray L, Murphy S, Roberts L, Glover P, et al. Hypertension in response to autoantibodies to the angiotensin II type I receptor (AT1-AA) in pregnant rats: role of endothelin-1. Hypertension. 2009;54:905-9 pubmed publisher
    ..Collectively, these data support the hypothesis that one potential pathway whereby AT1-AAs increase blood pressure during pregnancy is by an ET-1-dependent mechanism. ..
  41. DeRuisseau L, Recca D, Mogle J, Zoccolillo M, DeRuisseau K. Metallothionein deficiency leads to soleus muscle contractile dysfunction following acute spinal cord injury in mice. Am J Physiol Regul Integr Comp Physiol. 2009;297:R1795-802 pubmed publisher
    ..These findings suggest a role of MT in mediating protective adaptations in skeletal muscle following disuse mediated by spinal cord injury. ..
  42. Van Kampen J, Eckman C. Agonist-induced restoration of hippocampal neurogenesis and cognitive improvement in a model of cholinergic denervation. Neuropharmacology. 2010;58:921-9 pubmed publisher
  43. Paquette M, Anderson A, Lewis J, Meshul C, Johnson S, Paul Berger S. MK-801 inhibits L-DOPA-induced abnormal involuntary movements only at doses that worsen parkinsonism. Neuropharmacology. 2010;58:1002-8 pubmed publisher
    ..We conclude that noncompetitive NMDA antagonists are unlikely to suppress dyskinesia clinically without worsening parkinsonism. ..
  44. PAULK N, Wursthorn K, Wang Z, Finegold M, Kay M, Grompe M. Adeno-associated virus gene repair corrects a mouse model of hereditary tyrosinemia in vivo. Hepatology. 2010;51:1200-8 pubmed publisher
    ..In this model, repaired hepatocytes have a selective growth advantage and are thus able to proliferate to efficiently repopulate mutant livers and cure the underlying metabolic disease...
  45. Overturf K, Al Dhalimy M, Tanguay R, Brantly M, Ou C, Finegold M, et al. Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinaemia type I. Nat Genet. 1996;12:266-73 pubmed
    ..Our results demonstrate that in vivo selection is a useful strategy for hepatic gene therapy and may lead to effective treatment of human HT1 by retroviral gene transfer. ..
  46. Katz J, Black K, Michalek S. Host responses to recombinant hemagglutinin B of Porphyromonas gingivalis in an experimental rat model. Infect Immun. 1999;67:4352-9 pubmed
    ..These results demonstrate the effectiveness of purified rHag B in inducing a protective immune response and support the potential usefulness of this component of P. gingivalis in the development of a vaccine against adult periodontitis. ..
  47. Scolapio J. Treatment of short-bowel syndrome. Curr Opin Clin Nutr Metab Care. 2001;4:557-60 pubmed
    ..Although experimental animal data would suggest that various growth factors are of benefit in the treatment of short-bowel syndrome, only a few clinical studies have made the same claim. ..
  48. Sweitzer S, White K, Dutta C, DeLeo J. The differential role of spinal MHC class II and cellular adhesion molecules in peripheral inflammatory versus neuropathic pain in rodents. J Neuroimmunol. 2002;125:82-93 pubmed
    ..These findings suggest that central neuroimmune activation may contribute to the maintenance of neuropathic pain following peripheral L5 spinal nerve transection but not following a peripheral inflammatory insult. ..
  49. Ge Y, Ohta T, Driscoll D, Nicholls R, Kalra S. Anorexigenic melanocortin signaling in the hypothalamus is augmented in association with failure-to-thrive in a transgenic mouse model for Prader-Willi syndrome. Brain Res. 2002;957:42-5 pubmed
  50. Lam M, Nadeau J. Genetic control of susceptibility to spontaneous testicular germ cell tumors in mice. APMIS. 2003;111:184-90; discussion 191 pubmed
    ..Bilateral TGCTs result from the coincidental occurrence of unilateral tumors. These results highlight the important contributions that this mouse model can make to studies of TGCT susceptibility in humans. ..
  51. Spolarics Z, Condon M, Siddiqi M, Machiedo G, Deitch E. Red blood cell dysfunction in septic glucose-6-phosphate dehydrogenase-deficient mice. Am J Physiol Heart Circ Physiol. 2004;286:H2118-26 pubmed
  52. Krakowka S, Felsburg P. Gnotobiotics and immunopathology: the use of the gnotobiotic environment to study acquired and inherited immunodeficiency diseases. Vet Immunol Immunopathol. 2005;108:165-75 pubmed
    ..While many issues are unresolved, these data suggest that, through the use of the gnotobiotic environment, xenotransplantation (human-to-dog) may yield a stable and immunologically functional human-dog chimera. ..
  53. Ting A, Kimler B, Fabian C, Petroff B. Characterization of a preclinical model of simultaneous breast and ovarian cancer progression. Carcinogenesis. 2007;28:130-5 pubmed
    ..This combined breast and ovarian cancer rat model (systemic E2 treatment and local ovarian DMBA) may be useful for future dual target breast and ovarian cancer prevention studies. ..
  54. Gnerer J, Kreber R, Ganetzky B. wasted away, a Drosophila mutation in triosephosphate isomerase, causes paralysis, neurodegeneration, and early death. Proc Natl Acad Sci U S A. 2006;103:14987-93 pubmed
    ..Our results highlight an essential protective role of Tpi and support the idea that advanced glycation end products may also contribute to pathogenesis of other neurological disorders...
  55. Morey S, Smiraglia D, James S, Yu J, Moser M, Foster B, et al. DNA methylation pathway alterations in an autochthonous murine model of prostate cancer. Cancer Res. 2006;66:11659-67 pubmed
  56. Alvarez C, Wiederhold N, McConville J, Peters J, Najvar L, Graybill J, et al. Aerosolized nanostructured itraconazole as prophylaxis against invasive pulmonary aspergillosis. J Infect. 2007;55:68-74 pubmed
    ..Prophylactic aerosolization of nanostructured SFL significantly improved survival and limited invasive disease of small airways due to A. fumigatus. ..
  57. Mahamed S, Mitchell G. Simulated apnoeas induce serotonin-dependent respiratory long-term facilitation in rats. J Physiol. 2008;586:2171-81 pubmed publisher
    ..Apnoea-induced LTF may have implications for the maintenance of breathing stability, particularly during sleep. ..
  58. Ikehata K, Duzhak T, Galeva N, Ji T, Koen Y, Hanzlik R. Protein targets of reactive metabolites of thiobenzamide in rat liver in vivo. Chem Res Toxicol. 2008;21:1432-42 pubmed publisher
  59. Suzuki M, McHugh J, Tork C, Shelley B, Hayes A, Bellantuono I, et al. Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALS. Mol Ther. 2008;16:2002-10 pubmed publisher
    ..This preclinical data provides a novel and practical approach toward ex vivo gene therapy for ALS. ..
  60. Mukherjea D, Jajoo S, Whitworth C, Bunch J, Turner J, Rybak L, et al. Short interfering RNA against transient receptor potential vanilloid 1 attenuates cisplatin-induced hearing loss in the rat. J Neurosci. 2008;28:13056-65 pubmed publisher
    ..These data provide a link between NOX3 and TRPV1 in cisplatin-induced hearing loss and suggest that targeting these proteins for knockdown by siRNA could serve as a novel approach in treating cisplatin ototoxicity. ..
  61. Li Y, Ogle M, Wallace G, Lu Z, Yu S, Wei L. Erythropoietin attenuates intracerebral hemorrhage by diminishing matrix metalloproteinases and maintaining blood-brain barrier integrity in mice. Acta Neurochir Suppl. 2008;105:105-12 pubmed
    ..Our study provides additional evidence for the mechanism of rhEPO's neurovascular protective effects and a potential clinical application in the treatment of ICH. ..
  62. Offner H, Firestein G, Boyle D, Pieters R, Frincke J, Garsd A, et al. An orally bioavailable synthetic analog of an active dehydroepiandrosterone metabolite reduces established disease in rodent models of rheumatoid arthritis. J Pharmacol Exp Ther. 2009;329:1100-9 pubmed publisher
  63. Xu R, DeVries S, Camboni M, Martin P. Overexpression of Galgt2 reduces dystrophic pathology in the skeletal muscles of alpha sarcoglycan-deficient mice. Am J Pathol. 2009;175:235-47 pubmed publisher
  64. Pan J, Oh S, Lee W, Petersen B. Bone marrow-derived progenitor cells could modulate pancreatic cancer tumorigenesis via peritumoral microenvironment in a rat model. Oncol Res. 2009;17:339-45 pubmed
    ..However, no CD26 signal was detected in the tumors. Within this model, there appeared to be no evidence supporting that BMPC turned into tumor cells directly. BMPC could modulate pancreatic cancer growth through tumor microenvironment. ..
  65. Loveless S, Api A, Crevel R, Debruyne E, Gamer A, Jowsey I, et al. Potency values from the local lymph node assay: application to classification, labelling and risk assessment. Regul Toxicol Pharmacol. 2010;56:54-66 pubmed publisher
  66. Sanchez C. Growth-plate cartilage in chronic renal failure. Pediatr Nephrol. 2010;25:643-9 pubmed publisher
    ..Recent findings have also shown the tight connection between chondro/osteogenesis, hematopoiesis, and immunogenesis. ..
  67. Biezonski D, Meyer J. Effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin transporter and vesicular monoamine transporter 2 protein and gene expression in rats: implications for MDMA neurotoxicity. J Neurochem. 2010;112:951-62 pubmed publisher
    ..These results demonstrate that MDMA causes substantial regulatory changes in the expression of serotonergic markers, thus questioning the need to invoke distal axotomy as an explanation of MDMA-related serotonergic deficits. ..
  68. Kelly Scumpia K, Scumpia P, Delano M, Weinstein J, Cuenca A, Wynn J, et al. Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10. J Exp Med. 2010;207:319-26 pubmed publisher
    ..Using a low lethality sepsis model, we identify a critical role of type I IFN-dependent CXCL10 in host defense during polymicrobial sepsis by increasing neutrophil recruitment and function. ..
  69. Wortham B, Oliveira M, Fetherston J, Perry R. Polyamines are required for the expression of key Hms proteins important for Yersinia pestis biofilm formation. Environ Microbiol. 2010;12:2034-47 pubmed publisher
    ..Finally, we have shown that polyamines play a role in bubonic plague. ..
  70. Zimmerman B, Niewiesk S, Lairmore M. Mouse models of human T lymphotropic virus type-1-associated adult T-cell leukemia/lymphoma. Vet Pathol. 2010;47:677-89 pubmed publisher
  71. Britt J, Kane J, Spaeth C, Zuzek A, Robinson G, Gbanaglo M, et al. Polyethylene glycol rapidly restores axonal integrity and improves the rate of motor behavior recovery after sciatic nerve crush injury. J Neurophysiol. 2010;104:695-703 pubmed publisher
    ..These and other data show that PEG-fusion not only rapidly restores physiological and morphological axonal continuity, but also more quickly improves behavioral recovery. ..
  72. Jung S, Bullis J, Lau I, Jones T, Warner L, Poolos N. Downregulation of dendritic HCN channel gating in epilepsy is mediated by altered phosphorylation signaling. J Neurosci. 2010;30:6678-88 pubmed publisher
  73. Shen A, O Leary K, Dubielzig R, Drinkwater N, Murphy C, Kasper C, et al. The PPCD1 mouse: characterization of a mouse model for posterior polymorphous corneal dystrophy and identification of a candidate gene. PLoS ONE. 2010;5:e12213 pubmed publisher
    ..Similarly, CSRP2BP haploinsufficiency may lead to human PPCD. ..
  74. Back S, Han B, Luo N, Chricton C, Xanthoudakis S, Tam J, et al. Selective vulnerability of late oligodendrocyte progenitors to hypoxia-ischemia. J Neurosci. 2002;22:455-63 pubmed
    ..2001), maturation-dependent vulnerability of OL progenitors to hypoxia-ischemia may underlie the selective vulnerability to PVL of the white matter in the premature infant. ..
  75. Toth L, Verhulst S. Strain differences in sleep patterns of healthy and influenza-infected inbred mice. Behav Genet. 2003;33:325-36 pubmed
    ..These data support and expand the existing literature that indicates genetic modulation of sleep both in healthy mice and in mice undergoing viral infection. ..
  76. Beach T, Potter P, Kuo Y, Emmerling M, Durham R, Webster S, et al. Cholinergic deafferentation of the rabbit cortex: a new animal model of Abeta deposition. Neurosci Lett. 2000;283:9-12 pubmed
    ..Biochemical measurements confirmed that lesioned animals had 2.5- and 8-fold elevations of cortical Abeta40 and Abeta42, respectively. Cholinergic deafferentation may be one factor that can contribute to Abeta deposition. ..
  77. Stoner G, Casto B, Ralston S, Roebuck B, Pereira C, Bailey G. Development of a multi-organ rat model for evaluating chemopreventive agents: efficacy of indole-3-carbinol. Carcinogenesis. 2002;23:265-72 pubmed
    ..The results of this study clearly demonstrate that I-3-C is not an appropriate chemoprotective agent for human use, in spite of its effects in the breast and colon in this rat animal model. ..
  78. Brake T, Connor J, Petereit D, Lambert P. Comparative analysis of cervical cancer in women and in a human papillomavirus-transgenic mouse model: identification of minichromosome maintenance protein 7 as an informative biomarker for human cervical cancer. Cancer Res. 2003;63:8173-80 pubmed
    ..The uniform staining pattern and strong signal for MCM7 suggest that MCM7 may be a highly informative biomarker for cervical cancer. ..
  79. Boos L, Szalai A, Barnum S. Murine complement C4 is not required for experimental autoimmune encephalomyelitis. Glia. 2005;49:158-60 pubmed
    ..These results support the conclusion that the contribution of murine complement to the pathogenesis of demyelinating disease is realized via the alternative pathway. ..
  80. Demehri S, Corbin A, Loriaux M, Druker B, Deininger M. Establishment of a murine model of aggressive systemic mastocytosis/mast cell leukemia. Exp Hematol. 2006;34:284-8 pubmed
    ..This easy and inexpensive tumor model should be useful for testing potential drugs with activity against KIT(D816V)...
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