Experts and Doctors on amino acids in Spain


Locale: Spain
Topic: amino acids

Top Publications

  1. Mateu M, Martinez M, Rocha E, Andreu D, Parejo J, Giralt E, et al. Implications of a quasispecies genome structure: effect of frequent, naturally occurring amino acid substitutions on the antigenicity of foot-and-mouth disease virus. Proc Natl Acad Sci U S A. 1989;86:5883-7 pubmed
    ..The results implicate the extreme heterogeneity of foot-and-mouth disease virus as an important element of viral pathogenesis. ..
  2. Aranjuelo I, Cabrera Bosquet L, Morcuende R, Avice J, Nogués S, Araus J, et al. Does ear C sink strength contribute to overcoming photosynthetic acclimation of wheat plants exposed to elevated CO2?. J Exp Bot. 2011;62:3957-69 pubmed publisher
  3. Ocampo S, Albericio F, Fernandez I, Vilaseca M, Eritja R. A straightforward synthesis of 5'-peptide oligonucleotide conjugates using N(alpha)-Fmoc-protected amino acids. Org Lett. 2005;7:4349-52 pubmed
    ..The method uses commercially available reagents and is successful with most natural amino acids. The simplicity of the method may encourage researchers to prepare new oligonucleotide-peptide conjugates with novel properties. ..
  4. Li J, Ezquer I, Bahaji A, Montero M, Ovecka M, Baroja Fernandez E, et al. Microbial volatile-induced accumulation of exceptionally high levels of starch in Arabidopsis leaves is a process involving NTRC and starch synthase classes III and IV. Mol Plant Microbe Interact. 2011;24:1165-78 pubmed publisher
  5. Gracia Marco L, Bel Serrat S, Cuenca Garcia M, Gonzalez Gross M, Pedrero Chamizo R, Manios Y, et al. Amino acids intake and physical fitness among adolescents. Amino Acids. 2017;49:1041-1052 pubmed publisher
    ..In conclusion, we failed to detect any associations between any of the evaluated AAs and physical fitness after taking into account the effect of multiple testing. ..
  6. Tadeo X, López Méndez B, Trigueros T, Laín A, Castaño D, Millet O. Structural basis for the aminoacid composition of proteins from halophilic archea. PLoS Biol. 2009;7:e1000257 pubmed publisher
    ..Conversely, we quantitatively demonstrate that halophilicity is directly related to a decrease in the accessible surface area. ..
  7. Ortego L, Meireles M, Kasper C, Laguna A, Villacampa M, Gimeno M. Group 11 complexes with amino acid derivatives: Synthesis and antitumoral studies. J Inorg Biochem. 2016;156:133-44 pubmed publisher
    ..These experiments showed that the mechanism by which the complexes inhibit cell proliferation inducing cell death in NIH-3T3 cells is mainly apoptotic. ..
  8. Rodriguez Aparicio L, Luengo J, González Clemente C, Reglero A. Purification and characterization of the nuclear cytidine 5'-monophosphate N-acetylneuraminic acid synthetase from rat liver. J Biol Chem. 1992;267:9257-63 pubmed
    ..6 mM), whereas CMP-NeuAc, high CTP concentrations, and other nucleotides (CDP, CMP, ATP, UTP, GTP, and TTP) inhibited the enzyme to different extents. ..
  9. Sánchez Sampedro A, Kim H, Choi Y, Verpoorte R, Corchete P. Metabolomic alterations in elicitor treated Silybum marianum suspension cultures monitored by nuclear magnetic resonance spectroscopy. J Biotechnol. 2007;130:133-42 pubmed
    ..The results obtained in this study will permit in the future to identify candidate components of the signalling pathway involved in the stimulation of the constitutive pathway of silymarin. ..

More Information


  1. Etxeberria E, Baroja Fernandez E, Muñoz F, Pozueta Romero J. Sucrose-inducible endocytosis as a mechanism for nutrient uptake in heterotrophic plant cells. Plant Cell Physiol. 2005;46:474-81 pubmed
    ..These results demonstrate the existence of a sucrose-inducible endocytic process as a viable mechanism for solute transport into the vacuole of storage cells. ..
  2. Garde Cerdán T, Portu J, López R, Santamaría P. Effect of methyl jasmonate application to grapevine leaves on grape amino acid content. Food Chem. 2016;203:536-539 pubmed publisher
    ..This finding suggests that methyl jasmonate treatment might be conducive to obtain wines of higher quality since must amino acid composition could affect the wine volatile composition and the fermentation kinetics. ..
  3. Orcaray L, Igal M, Marino D, Zabalza A, Royuela M. The possible role of quinate in the mode of action of glyphosate and acetolactate synthase inhibitors. Pest Manag Sci. 2010;66:262-9 pubmed publisher
    ..This ability to mimic the herbicide effects suggests a possible link between the mode of action of these herbicides and the potential role of quinate as a natural herbicide. ..
  4. Mayas M, Ramírez Expósito M, Garcia M, Ramirez M, Martínez Martos J. Ethanol modifies differently aspartyl- and glutamyl-aminopeptidase activities in mouse frontal cortex synaptosomes. Brain Res Bull. 2002;57:195-203 pubmed
    ..The changes in AspAP and GluAP activities as a consequence of EtOH administration and their role in the brain RAS are discussed. ..
  5. Reguera J, Grueso E, Carreira A, Sánchez Martinez C, Almendral J, Mateu M. Functional relevance of amino acid residues involved in interactions with ordered nucleic acid in a spherical virus. J Biol Chem. 2005;280:17969-77 pubmed
    ..Their effect appears to be mediated by the non-covalent interactions they establish with the viral DNA. In addition, at least one acidic residue at each DNA-binding region is needed for DNA packaging. ..
  6. Credali A, Díaz Quintana A, García Calderón M, De la Rosa M, Marquez A, Vega J. Structural analysis of K+ dependence in L-asparaginases from Lotus japonicus. Planta. 2011;234:109-22 pubmed publisher
    ..On the other hand, LjNSE2 but not LjNSE1 showed ?-aspartyl-hydrolase activity (K(m) = 0.54 mM for ?-Asp-His). These results are discussed in terms of the different physiological significance of these isoenzymes in plants. ..
  7. Ferrer J, Pérez Pomares F, Bonete M. NADP-glutamate dehydrogenase from the halophilic archaeon Haloferax mediterranei: enzyme purification, N-terminal sequence and stability. FEMS Microbiol Lett. 1996;141:59-63 pubmed
    ..At pH 8.5 the enzyme has Kms of 0.018, 0.34 and 4.2 mM for NADP+, 2-oxoglutarate and ammonium, respectively. Amino acid composition and sequence of the first 16 residues of the N-terminus have been determined. ..
  8. Hidalgo F, León M, Zamora R. Amino acid decarboxylations produced by lipid-derived reactive carbonyls in amino acid mixtures. Food Chem. 2016;209:256-61 pubmed publisher
    ..All these results suggest that the amine/aldehyde ratio obtained by amino acid degradation can be modified by adding free amino acids during food formulation. ..
  9. Reguera R, Balaña Fouce R, Showalter M, Hickerson S, Beverley S. Leishmania major lacking arginase (ARG) are auxotrophic for polyamines but retain infectivity to susceptible BALB/c mice. Mol Biochem Parasitol. 2009;165:48-56 pubmed publisher
  10. Marin J, Mendiola P, Hernandez M, de Costa J, Zamora S. Influence of exercise on plasma and muscle free amino acids in trained rainbow trout. J Physiol Biochem. 1999;55:293-9 pubmed
    ..This suggests a metabolic adaptation to exercise, with amino acid level retention in the muscle. ..
  11. Adrover M, Vilanova B, Frau J, Munoz F, Donoso J. The pyridoxamine action on Amadori compounds: A reexamination of its scavenging capacity and chelating effect. Bioorg Med Chem. 2008;16:5557-69 pubmed publisher
    ..On the other hand results explain the lack of inhibition of aminoguanidine (a glycation inhibitor) in the post-Amadori reactions. ..
  12. Canales J, Flores Monterrosso A, Rueda López M, Avila C, Canovas F. Identification of genes regulated by ammonium availability in the roots of maritime pine trees. Amino Acids. 2010;39:991-1001 pubmed publisher
    ..Functional analyses and exploration of the natural variability in maritime pine populations for a number of relevant genes are underway. ..
  13. Sebastian E, Alcoceba M, Balanzategui A, Marin L, Montes Moreno S, Flores T, et al. Molecular characterization of immunoglobulin gene rearrangements in diffuse large B-cell lymphoma: antigen-driven origin and IGHV4-34 as a particular subgroup of the non-GCB subtype. Am J Pathol. 2012;181:1879-88 pubmed publisher
    ..IGHV gene repertoire is remarkably biased, implying an antigen-driven origin in DLBCL. The particular features in the sequence of the immunoglobulins suggest the existence of particular subgroups within the non-GCB subtype. ..
  14. Garnica M, Houdusse F, Zamarreño A, Garcia Mina J. Nitrate modifies the assimilation pattern of ammonium and urea in wheat seedlings. J Sci Food Agric. 2010;90:357-69 pubmed publisher
    ..Finally, nitrate effects on amino acid concentration indicate that, whereas ammonium assimilation takes place principally in the root, urea and nitrate assimilation occurred in the shoot, under the conditions of the experiment. ..
  15. Farrera Sinfreu J, Aviñó A, Navarro I, Aymami J, Beteta N, Varón S, et al. Design, synthesis and antiproliferative properties of oligomers with chromophore units linked by amide backbones. Bioorg Med Chem Lett. 2008;18:2440-4 pubmed publisher
    ..Specifically, chromophore units with protected-amino groups and one carboxylic group are described, together with methods to assemble these units using peptide chemistry. Some of these compounds have antiproliferative activity. ..
  16. Spengler J, Ruiz Rodríguez J, Yraola F, Royo M, Winter M, Burger K, et al. A novel protecting/activating strategy for beta-hydroxy acids and its use in convergent peptide synthesis. J Org Chem. 2008;73:2311-4 pubmed publisher
  17. Latorre Moratalla M, Bover Cid S, Talon R, Aymerich T, Garriga M, Zanardi E, et al. Distribution of aminogenic activity among potential autochthonous starter cultures for dry fermented sausages. J Food Prot. 2010;73:524-8 pubmed
    ..From the aminogenic point of view, Lactobacillus plantarum, Lactobacillus sakei, and Staphylococcus xylosus strains would be the most suitable for use as autochthonous starter cultures for traditional fermented sausages. ..
  18. Mikhailov A, Torrado M, Korochkin L, Kopantzeva M, Mendez J. Male-predominant carboxylesterase expression in the reproductive system of molluscs and insects: immunochemical and biochemical similarity between Mytilus male associated polypeptide (MAP) and Drosophila sex-specific esterase S. Comp Biochem Physiol B Biochem Mol Biol. 1997;118:197-208 pubmed
    ..Taken together, the results indicate that MAP of M. galloprovincialis is structurally and functionally related to esterase S of D. virilis ejaculatory bulbs. ..
  19. Domingo A, González Jurado J, Maroto M, Diaz C, Vinós J, Carrasco C, et al. Troponin-T is a calcium-binding protein in insect muscle: in vivo phosphorylation, muscle-specific isoforms and developmental profile in Drosophila melanogaster. J Muscle Res Cell Motil. 1998;19:393-403 pubmed
    ..Our results suggest that this property could be specific to insect TnTs and may be related to the long, extremely acidic polyglutamic carboxy-terminus present in these polypeptides, which does not occur in non-arthropod TnTs. ..
  20. Pérez Delgado C, García Calderón M, Sanchez D, Udvardi M, Kopka J, Marquez A, et al. Transcriptomic and metabolic changes associated with photorespiratory ammonium accumulation in the model legume Lotus japonicus. Plant Physiol. 2013;162:1834-48 pubmed publisher
  21. Suarez M, Martin M, Ferrer E, Garrido Pertierra A. Purification and characterization of 4-hydroxybenzoate 3-hydroxylase from a Klebsiella pneumoniae mutant strain. Arch Microbiol. 1995;164:70-7 pubmed
    ..6. Steady-state kinetics were analyzed; the initial velocity patterns were consistent with a concerted substitution mechanism. The purified enzyme had 362 amino acid residues, and a tyrosine seemed to be involved in substrate activation. ..
  22. Beato V, Teresa Navarro Gochicoa M, Rexach J, Begoña Herrera Rodríguez M, Camacho Cristóbal J, Kempa S, et al. Expression of root glutamate dehydrogenase genes in tobacco plants subjected to boron deprivation. Plant Physiol Biochem. 2011;49:1350-4 pubmed publisher
    ..Our results suggest that GDH enzyme plays an important role in metabolic acclimation of tobacco roots to B deprivation. A putative model to explain these results is proposed and discussed...
  23. Diaz M, Medina V, Gomez T, Lorenzo A. Membrane mechanisms for electrogenic Na(+)-independent L-alanine transport in the lizard duodenal mucosa. Am J Physiol Regul Integr Comp Physiol. 2000;279:R925-35 pubmed
    ..Potassium exit through a basolateral barium-sensitive conductance provides the key step for the electrogenicity of L-alanine absorption...
  24. De Sousa Coelho A, Marrero P, Haro D. Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation. Biochem J. 2012;443:165-71 pubmed publisher
    ..These results add FGF21 gene induction to the transcriptional programme initiated by increased levels of ATF4 and offer a new mechanism for the induction of the FGF21 gene expression under nutrient deprivation. ..
  25. Baldoma L, Aguilar J. Involvement of lactaldehyde dehydrogenase in several metabolic pathways of Escherichia coli K12. J Biol Chem. 1987;262:13991-6 pubmed
    ..The enzyme, previously described as specific for lactaldehyde, is thus identified as a dehydrogenase with a fairly general role in aldehyde oxidation, and it is probably involved in several metabolic pathways. ..
  26. Valbuena N, Guan K, Moreno S. The Vam6 and Gtr1-Gtr2 pathway activates TORC1 in response to amino acids in fission yeast. J Cell Sci. 2012;125:1920-8 pubmed publisher
    ..Our data demonstrate the existence of an evolutionarily conserved pathway with the Vam6 and Gtr1-Gtr2 pathway activating TORC1, which in turns stimulates cell growth and inhibits sexual differentiation. ..
  27. Spengler J, Bottcher C, Albericio F, Burger K. Hexafluoroacetone as protecting and activating reagent: new routes to amino, hydroxy, and mercapto acids and their application for peptide and glyco- and depsipeptide modification. Chem Rev. 2006;106:4728-46 pubmed
  28. Martí I, Rubio J, Bolte M, Burguete M, Vicent C, Quesada R, et al. Tuning chloride binding, encapsulation, and transport by peripheral substitution of pseudopeptidic tripodal small cages. Chemistry. 2012;18:16728-41 pubmed publisher
    ..Therefore, the pseudopeptidic cages sharing the same binding motif for chloride rendered very different interaction and transport properties depending on the peripheral substitution...
  29. Ferrer Martínez A, Felipe A, Mata J, Casado F, Pastor Anglada M. Molecular cloning of a bovine renal G-protein coupled receptor gene (bRGR): regulation of bRGR mRNA levels by amino acid availability. Biochem Biophys Res Commun. 1997;238:107-12 pubmed
    ..These data suggest that bRGR1 may be an amino acid-regulated gene. ..
  30. Tubert P, Laurents D, Ribo M, Bruix M, Vilanova M, Benito A. Interactions crucial for three-dimensional domain swapping in the HP-RNase variant PM8. Biophys J. 2011;101:459-67 pubmed publisher
  31. Lama J, Sanz M, Rodr guez P. A role for 3AB protein in poliovirus genome replication. J Biol Chem. 1995;270:14430-8 pubmed
    ..Our results suggest that 3AB protein functions in vivo as a co-factor of the viral polymerase and that the activity of 3AB may be regulated by proteolytic processing...
  32. Zabalza A, Orcaray L, Igal M, Schauer N, Fernie A, Geigenberger P, et al. Unraveling the role of fermentation in the mode of action of acetolactate synthase inhibitors by metabolic profiling. J Plant Physiol. 2011;168:1568-75 pubmed publisher
    ..As growth is arrested, carbohydrates and glycolytic intermediates accumulate and energy becomes more available...
  33. Valbuena N, Rozalén A, Moreno S. Fission yeast TORC1 prevents eIF2? phosphorylation in response to nitrogen and amino acids via Gcn2 kinase. J Cell Sci. 2012;125:5955-9 pubmed publisher
    ..Inhibition of TORC1, either by rapamycin treatment, mutation of Tor2 or nitrogen deprivation, induces Gcn2-dependent phosphorylation of eIF2?. ..
  34. Neef A, Latorre A, Peretó J, Silva F, Pignatelli M, Moya A. Genome economization in the endosymbiont of the wood roach Cryptocercus punctulatus due to drastic loss of amino acid synthesis capabilities. Genome Biol Evol. 2011;3:1437-48 pubmed publisher
  35. Carnicer M, ten Pierick A, van Dam J, Heijnen J, Albiol J, van Gulik W, et al. Quantitative metabolomics analysis of amino acid metabolism in recombinant Pichia pastoris under different oxygen availability conditions. Microb Cell Fact. 2012;11:83 pubmed publisher
    ..Overall, the results obtained, combined with previous transcriptomic and proteomic analyses provide a systematic metabolic fingerprint of the oxygen availability impact on recombinant protein production in P. pastoris. ..
  36. Onrubia M, Moyano E, Bonfill M, Cusido R, Goossens A, Palazon J. Coronatine, a more powerful elicitor for inducing taxane biosynthesis in Taxus media cell cultures than methyl jasmonate. J Plant Physiol. 2013;170:211-9 pubmed publisher
  37. Ramos A, Macias J, Gil J. Cloning, sequencing and expression of the gene encoding elongation factor P in the amino-acid producer Brevibacterium lactofermentum (Corynebacterium glutamicum ATCC 13869). Gene. 1997;198:217-22 pubmed
    ..Disruption experiments using an internal fragment of the EF-P gene or a disrupted EF-P gene in suicide plasmids always failed, suggesting that the gene is needed for cell viability. ..
  38. Scalschi L, Vicedo B, Camañes G, Fernández Crespo E, Lapeña L, González Bosch C, et al. Hexanoic acid is a resistance inducer that protects tomato plants against Pseudomonas syringae by priming the jasmonic acid and salicylic acid pathways. Mol Plant Pathol. 2013;14:342-55 pubmed publisher
    ..In this work, we observed that Hx seems to inhibit stomatal opening in?planta in the presence of COR, which suggests that, on infection in tomato, this treatment suppresses effector action to prevent bacterial entry into the mesophyll. ..
  39. Vila R, Benito A, Ribo M, Vilanova M. Mapping the stability clusters in bovine pancreatic ribonuclease A. Biopolymers. 2009;91:1038-47 pubmed publisher
  40. Molina M, Barrera F, Encinar J, Renart M, Fern ndez A, Poveda J, et al. N-type inactivation of the potassium channel KcsA by the Shaker B "ball" peptide: mapping the inactivating peptide-binding epitope. J Biol Chem. 2008;283:18076-85 pubmed publisher
    ..Indeed, docking such a beta-hairpin structure into an open pore model for K(+) channels to simulate the inactivating peptide/channel complex predicts interactions well in agreement with the experimental observations...
  41. Pernil R, Picossi S, Mariscal V, Herrero A, Flores E. ABC-type amino acid uptake transporters Bgt and N-II of Anabaena sp. strain PCC 7120 share an ATPase subunit and are expressed in vegetative cells and heterocysts. Mol Microbiol. 2008;67:1067-80 pubmed publisher
    ..Whereas Bgt is dispensable for diazotrophic growth, N-II appears to contribute together with N-I to the diazotrophic physiology of this cyanobacterium. ..
  42. Cabiscol E, Tamarit J, Ros J. Oxidative stress in bacteria and protein damage by reactive oxygen species. Int Microbiol. 2000;3:3-8 pubmed
    ..This paper reviews major key points in the generation of reactive oxygen species in bacteria, defense mechanisms and genetic responses to oxidative stress. Special attention is paid to the oxidative damage to proteins. ..
  43. Perez A, Olias R, Luaces P, Sanz C. Biosynthesis of strawberry aroma compounds through amino acid metabolism. J Agric Food Chem. 2002;50:4037-42 pubmed
    ..The role of enzymatic activities within the amino acid metabolic pathway in strawberry fruits is discussed. ..
  44. Turner K, Hawkins T, Yáñez J, Anadón R, Wilson S, Folgueira M. Afferent Connectivity of the Zebrafish Habenulae. Front Neural Circuits. 2016;10:30 pubmed publisher
    ..2014). ..
  45. Morillas M, Gomez Puertas P, Bentebibel A, Sellés E, Casals N, Valencia A, et al. Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition. Mutation of methionine 593 abolishes malonyl-CoA inhibition. J Biol Chem. 2003;278:9058-63 pubmed
    ..Ariño, J., Valencia, A., Hegardt, F. G., Serra, D., and Asins, G. (2002) J. Biol. Chem. 277, 11473-11480). Met(593) may participate in the interaction of malonyl-CoA in the second affinity site, whose location has not been reported. ..
  46. Pineda M, Font M, Bassi M, Manzoni M, Borsani G, Marigo V, et al. The amino acid transporter asc-1 is not involved in cystinuria. Kidney Int. 2004;66:1453-64 pubmed
    ..We have cloned human asc-1, assessed its transport characteristics, localized its expression in kidney, searched for mutations in cystinuria patients, and tested the transport function of variant E112D...
  47. Fern ndez Herrero L, Badet Denisot M, Badet B, Berenguer J. glmS of Thermus thermophilus HB8: an essential gene for cell-wall synthesis identified immediately upstream of the S-layer gene. Mol Microbiol. 1995;17:1-12 pubmed
    ..thermophilus, their unusual clustering in the chromosome could be related to the existence of specific mechanisms for their coordinate expression...
  48. Bodoy S, Fotiadis D, Stoeger C, Kanai Y, Palacin M. The small SLC43 family: facilitator system l amino acid transporters and the orphan EEG1. Mol Aspects Med. 2013;34:638-45 pubmed publisher
    ..In addition, LAT4 might contribute to the transfer of BCAAs from mother to fetus. Unfortunately, the EEG1 mouse model (EEG1(Y221?)) described here has not yet offered a clue to the physiological role of this orphan protein. ..
  49. Vilches C, Mendez C, Hardisson C, Salas J. Biosynthesis of oleandomycin by Streptomyces antibioticus: influence of nutritional conditions and development of resistance. J Gen Microbiol. 1990;136:1447-54 pubmed
    ..S. antibioticus develops oleandomycin resistance shortly before the antibiotic begins to be synthesized, showing a triphasic pattern of resistance: spores and producing mycelium are resistant, while non-producing mycelium is sensitive. ..
  50. Sarabia F, Vivar García C, García Castro M, García Ruiz C, Martín Gálvez F, Sánchez Ruiz A, et al. A highly stereoselective synthesis of glycidic amides based on a new class of chiral sulfonium salts: applications in asymmetric synthesis. Chemistry. 2012;18:15190-201 pubmed publisher
    ..The obtained epoxy amides were found to be useful as synthetic building blocks. Thus, they were reduced into their corresponding epoxy alcohols and subjected to oxirane-ring-opening reactions with different types of nucleophiles...
  51. Reboiro Jato D, Reboiro Jato M, Fdez Riverola F, Vieira C, Fonseca N, Vieira J. ADOPS--Automatic Detection Of Positively Selected Sites. J Integr Bioinform. 2012;9:200 pubmed publisher
    ..ADOPS software is freely available and can be downloaded from ..
  52. Amador C, Canosa I, Govantes F, Santero E. Lack of CbrB in Pseudomonas putida affects not only amino acids metabolism but also different stress responses and biofilm development. Environ Microbiol. 2010;12:1748-61 pubmed publisher
    ..putida that directly or indirectly controls a variety of metabolic and behavioural traits required for adaptation to changing environmental conditions. ..
  53. Soriano A, Ventura R, Molero A, Hoen R, Casado V, Cortés A, et al. Adenosine A2A receptor-antagonist/dopamine D2 receptor-agonist bivalent ligands as pharmacological tools to detect A2A-D2 receptor heteromers. J Med Chem. 2009;52:5590-602 pubmed publisher
    ..The dopamine/adenosine bivalent action could constitute a novel concept in Parkinson's disease pharmacotherapy. ..
  54. Ibarra Molero B, Loladze V, Makhatadze G, Sanchez Ruiz J. Thermal versus guanidine-induced unfolding of ubiquitin. An analysis in terms of the contributions from charge-charge interactions to protein stability. Biochemistry. 1999;38:8138-49 pubmed
    ..In general, our analysis suggests the possibility of enhancing protein thermal stability by adequately redesigning the distribution of solvent-exposed, charged residues on the native protein surface. ..
  55. Zanuy D, Rodríguez Ropero F, Nussinov R, Aleman C. Testing beta-helix terminal coils stability by targeted substitutions with non-proteogenic amino acids: a molecular dynamics study. J Struct Biol. 2007;160:177-89 pubmed
    ..We conclude that if the replacement does not alter the energy balance between attractive non-covalent interactions and steric hindrance, synthetic residues are suitable candidates to nucleate beta-helix formation. ..
  56. Tintos A, Gesto M, Míguez J, Soengas J. beta-Naphthoflavone and benzo(a)pyrene treatment affect liver intermediary metabolism and plasma cortisol levels in rainbow trout Oncorhynchus mykiss. Ecotoxicol Environ Saf. 2008;69:180-6 pubmed
    ..Furthermore, beta-NF treatment stimulated amino acid catabolism in liver. These metabolic changes can be associated with increased levels of plasma cortisol, and suggest a different metabolic behavior depending on PAHs. ..
  57. Fernandez E, Torrents D, Zorzano A, Palacin M, Chillarón J. Identification and functional characterization of a novel low affinity aromatic-preferring amino acid transporter (arpAT). One of the few proteins silenced during primate evolution. J Biol Chem. 2005;280:19364-72 pubmed
    ..The evolutionary implications of the silencing process and the roles of arpAT in transport of L-DOPA in the brain and in aromatic amino acid absorption are discussed. ..
  58. Morillas M, López Viñas E, Valencia A, Serra D, Gomez Puertas P, Hegardt F, et al. Structural model of carnitine palmitoyltransferase I based on the carnitine acetyltransferase crystal. Biochem J. 2004;379:777-84 pubmed
    ..e. Lys455, Lys505, Lys560 and Lys561, were also mutated. Only mutants K455A and K560A showed decreases in activity of 50%. The model rationalizes the finding of nine natural mutations in patients with hereditary L-CPT I deficiencies. ..