Experts and Doctors on amino acid sequence in United States


Locale: United States
Topic: amino acid sequence

Top Publications

  1. Wirtz M, Glanville R, Steinmann B, Rao V, Hollister D. Ehlers-Danlos syndrome type VIIB. Deletion of 18 amino acids comprising the N-telopeptide region of a pro-alpha 2(I) chain. J Biol Chem. 1987;262:16376-85 pubmed
  2. Cao X, Genge B, Wu L, Buzzi W, Showman R, Wuthier R. Characterization, cloning and expression of the 67-kDA annexin from chicken growth plate cartilage matrix vesicles. Biochem Biophys Res Commun. 1993;197:556-61 pubmed
    ..coli DH5 alpha in high yield; the physicochemical properties and the amino terminal sequence of the expressed protein exactly matched those of the native protein. ..
  3. Wu J, Newton A. Isolation, identification, and transcriptional specificity of the heat shock sigma factor sigma32 from Caulobacter crescentus. J Bacteriol. 1996;178:2094-101 pubmed
    ..crescentus sigma32 appear to be very similar to those of its E. coli counterpart, the C. crescentus rpoH gene contains a novel promoter structure and may be positively autoregulated in response to environmental stress. ..
  4. Smith C, Smith T, Smolak P, Friend D, Hagen H, Gerhart M, et al. Poxvirus genomes encode a secreted, soluble protein that preferentially inhibits beta chemokine activity yet lacks sequence homology to known chemokine receptors. Virology. 1997;236:316-27 pubmed
    ..The proposed function of vCCI is inhibition of the proinflammatory (antiviral) activities of beta chemokines...
  5. Kusano K, Berres M, Engels W. Evolution of the RECQ family of helicases: A drosophila homolog, Dmblm, is similar to the human bloom syndrome gene. Genetics. 1999;151:1027-39 pubmed
    ..We propose that invertebrates such as nematodes and insects are useful as model systems of human genetic diseases. ..
  6. Chernousov M, Rothblum K, Tyler W, Stahl R, Carey D. Schwann cells synthesize type V collagen that contains a novel alpha 4 chain. Molecular cloning, biochemical characterization, and high affinity heparin binding of alpha 4(V) collagen. J Biol Chem. 2000;275:28208-15 pubmed
    ..The restricted expression and unusual properties of alpha4(V)-containing collagen type V molecules suggest a unique and important role for these molecules in peripheral nerve development. ..
  7. Wang X, Hughes A, Tsukamoto T, Ando T, Kao T. Evidence that intragenic recombination contributes to allelic diversity of the S-RNase gene at the self-incompatibility (S) locus in Petunia inflata. Plant Physiol. 2001;125:1012-22 pubmed
    ..The implications of these findings are discussed. ..
  8. Xu L, Paulsen J, Yoo Y, Goodwin E, Strome S. Caenorhabditis elegans MES-3 is a target of GLD-1 and functions epigenetically in germline development. Genetics. 2001;159:1007-17 pubmed
    ..We propose that MES-3 acts epigenetically to induce a germline state that is inherited through both meiosis and mitosis and that is essential for survival of the germline...
  9. Wenzel Seifert K, Seifert R. Functional differences between human formyl peptide receptor isoforms 26, 98, and G6. Naunyn Schmiedebergs Arch Pharmacol. 2003;367:509-15 pubmed
    ..We conclude that (i) FPR isoforms 98 and G6 exhibit a partial G(i)-protein coupling defect relative to FPR-26 and that (ii) E346 critically determines constitutive activity, G(i)-protein coupling and physical state of FPR-26. ..

More Information

Publications1063 found, 100 shown here

  1. Dakappagari N, Pyles J, Parihar R, Carson W, Young D, Kaumaya P. A chimeric multi-human epidermal growth factor receptor-2 B cell epitope peptide vaccine mediates superior antitumor responses. J Immunol. 2003;170:4242-53 pubmed
    ..Peptide Abs targeting specific sites in the extracellular domain may be used for exploring the oncoprotein's functions. The multiepitope vaccine may have potential application in the treatment of HER-2-associated cancers. ..
  2. Glasfeld A, Guedon E, Helmann J, Brennan R. Structure of the manganese-bound manganese transport regulator of Bacillus subtilis. Nat Struct Biol. 2003;10:652-7 pubmed
    ..D8M binds only a single Mn2+ per monomer, owing to alteration of the metal-binding site. The sole retained metal site adopts pseudo-hexacoordinate geometry rather than the pseudo-heptacoordinate geometry of the MntR metal sites. ..
  3. Henriques C, Sanchez M, Tryon R, Landfear S. Molecular and functional characterization of the first nucleobase transporter gene from African trypanosomes. Mol Biochem Parasitol. 2003;130:101-10 pubmed
    ..1 mRNA is significantly more abundant in insect stage procyclic forms than in mammalian stage bloodstream forms, and the TbNT8.1 permease thus may represent a major route for purine nucleobase uptake in procyclic trypanosomes...
  4. Morris J, Willard B, Yin X, Jeserich G, Kinter M, Trapp B. The 36K protein of zebrafish CNS myelin is a short-chain dehydrogenase. Glia. 2004;45:378-91 pubmed
    ..This study identified a major myelin protein in zebrafish, 36K, as a member of the SDR superfamily; an expression pattern similar to other myelin genes was demonstrated. ..
  5. Smith A, Iversen P, Skilling D, Stein D, Bok K, Matson D. Vesivirus viremia and seroprevalence in humans. J Med Virol. 2006;78:693-701 pubmed
    ..These results justify further investigation of an association between Vesivirus infection and illness in humans. ..
  6. Huang S, Lee L, Hanson N, Lenaerts C, Hoehn H, Poot M, et al. The spectrum of WRN mutations in Werner syndrome patients. Hum Mutat. 2006;27:558-67 pubmed
    ..These, as well as inducible and complemented hTERT (catalytic subunit of human telomerase) immortalized skin fibroblast cell lines are available to qualified investigators. ..
  7. Fang C, Deng L, Keller C, Fukata M, Fukata Y, Chen G, et al. GODZ-mediated palmitoylation of GABA(A) receptors is required for normal assembly and function of GABAergic inhibitory synapses. J Neurosci. 2006;26:12758-68 pubmed
    ..We conclude that GODZ-mediated palmitoylation of GABA(A) receptors and possibly other substrates contributes selectively to the formation and normal function of GABAergic inhibitory synapses. ..
  8. Lee K, Eckert R. S100A7 (Psoriasin)--mechanism of antibacterial action in wounds. J Invest Dermatol. 2007;127:945-57 pubmed
    ..These studies also indicate that reduced S100A7 association with bacteria is associated with reduced antibacterial activity. ..
  9. Reddy K, Smith D, Plow E. Analysis of Fyn function in hemostasis and alphaIIbbeta3-integrin signaling. J Cell Sci. 2008;121:1641-8 pubmed publisher
    ..Our results suggest that Fyn and Src have distinct requirements for interaction with alphaIIbbeta3; and, consequently, the two SFK can mediate different functional responses. ..
  10. Grigsby I, Finger F. UNC-85, a C. elegans homolog of the histone chaperone Asf1, functions in post-embryonic neuroblast replication. Dev Biol. 2008;319:100-9 pubmed publisher
    ..5 n. We conclude that UNC-85 functions in post-embryonic DNA replication in ventral cord motor neuron precursors. ..
  11. Pereira E, Chen Y, Sanchez Y. Conserved ATRMec1 phosphorylation-independent activation of Chk1 by single amino acid substitution in the GD domain. Cell Cycle. 2009;8:1788-93 pubmed
    ..Therefore, we have uncovered a conserved mechanism for Chk1 regulation separate from the role of known ATR phosphorylation sites. ..
  12. Mongeon R, Walogorsky M, Urban J, Mandel G, Ono F, Brehm P. An acetylcholine receptor lacking both ? and ? subunits mediates transmission in zebrafish slow muscle synapses. J Gen Physiol. 2011;138:353-66 pubmed publisher
    ..The unique functional features offered by the ?(2)??(2) receptor likely play a central role in mediating the persistent contractions characteristic to this muscle type. ..
  13. Page R, Pruneda J, Amick J, Klevit R, Misra S. Structural insights into the conformation and oligomerization of E2~ubiquitin conjugates. Biochemistry. 2012;51:4175-87 pubmed publisher
    ..These results provide insights into the conformational diversity of E2~Ub conjugates and conjugate oligomers, and into their compatibility and interactions with E3s, which have important consequences for the ubiquitination process. ..
  14. Yu Z, Pan Y, Wang Z, Wang J, Lin Q. Genetically encoded cyclopropene directs rapid, photoclick-chemistry-mediated protein labeling in mammalian cells. Angew Chem Int Ed Engl. 2012;51:10600-4 pubmed publisher
    ..Cyclopropene exhibited fast reaction kinetics in the photoclick reaction and allowed rapid (ca. 2?min) labeling of proteins. ..
  15. Liu J, Yu D, Aiba Y, Pendergraff H, Swayze E, Lima W, et al. ss-siRNAs allele selectively inhibit ataxin-3 expression: multiple mechanisms for an alternative gene silencing strategy. Nucleic Acids Res. 2013;41:9570-83 pubmed publisher
  16. Moxley M, Zhang L, Christgen S, Tanner J, Becker D. Identification of a Conserved Histidine As Being Critical for the Catalytic Mechanism and Functional Switching of the Multifunctional Proline Utilization A Protein. Biochemistry. 2017;56:3078-3088 pubmed publisher
    ..These results indicate that His487 is critically important for the proline/P5C chemical step, conformational change kinetics, and functional switching in EcPutA. ..
  17. Reijnders M, Ansor N, Kousi M, Yue W, Tan P, Clarkson K, et al. RAC1 Missense Mutations in Developmental Disorders with Diverse Phenotypes. Am J Hum Genet. 2017;101:466-477 pubmed publisher
    ..We show that ultra-rare disorders caused by private, non-recurrent missense mutations that result in varying phenotypes are challenging to dissect, but can be delineated through focused international collaboration. ..
  18. McClain J, Rollo D, Rushing B, Bauer C. Rhodospirillum centenum utilizes separate motor and switch components to control lateral and polar flagellum rotation. J Bacteriol. 2002;184:2429-38 pubmed
    ..However, phylogenetic analysis of the MotA and MotB motor subunits suggests that the polar flagellum may have obtained a set of motor genes through a lateral transfer event...
  19. Yoon T, Dizin E, Cowan J. N-terminal iron-mediated self-cleavage of human frataxin: regulation of iron binding and complex formation with target proteins. J Biol Inorg Chem. 2007;12:535-42 pubmed
    ..The physiological significance of iron-mediated release of the N-terminal residues from this anionic surface is discussed. ..
  20. Paulmichl M, Li Y, Wickman K, Ackerman M, Peralta E, Clapham D. New mammalian chloride channel identified by expression cloning. Nature. 1992;356:238-41 pubmed
    ..The unusual sequence of this putative channel protein suggests a new class of ion channels not related to other previously cloned chloride channels. ..
  21. Gautam N, Northup J, Tamir H, Simon M. G protein diversity is increased by associations with a variety of gamma subunits. Proc Natl Acad Sci U S A. 1990;87:7973-7 pubmed
    ..Diversity in the structure of the gamma as well as the alpha and beta subunits and preferential associations between members of subunit families increase structural and possibly functional diversity of G proteins. ..
  22. Morris H, Larsen B, Billheimer J. A mass spectrometric study of the structure of sterol carrier protein SCP2 from rat liver. Biochem Biophys Res Commun. 1988;154:476-82 pubmed
    ..Carbohydrate analysis of SCP2 samples suggest the presence of tightly bound mannose oligosaccharide of 5-10 residues, although probably not in a glycoprotein linkage. ..
  23. Chai K, Ward D, Chao J, Chao L. Molecular cloning, sequence analysis, and chromosomal localization of the human protease inhibitor 4 (kallistatin) gene (PI4). Genomics. 1994;23:370-8 pubmed
    ..In a genomic DNA Southern blot, kallistatin-related genes were identified in monkey, mouse, rat, bovine, dog, cat, and a ground mole. The patterns of hybridization revealed clues of human serpin evolution. ..
  24. Clark D. Molecular and genetic analyses of Drosophila Prat, which encodes the first enzyme of de novo purine biosynthesis. Genetics. 1994;136:547-57 pubmed
  25. Schilke B, Forster J, Davis J, James P, Walter W, Laloraya S, et al. The cold sensitivity of a mutant of Saccharomyces cerevisiae lacking a mitochondrial heat shock protein 70 is suppressed by loss of mitochondrial DNA. J Cell Biol. 1996;134:603-13 pubmed
    ..We suggest that Ssh1 is required for normal mitochondrial DNA replication, and that disruption of this process in ssh1 cells results in a defect in mitochondrial function at low temperatures. ..
  26. Hurt J, Tu C, Laipis P, Silverman D. Catalytic properties of murine carbonic anhydrase IV. J Biol Chem. 1997;272:13512-8 pubmed
    ..The maximal turnover number kcat for hydration of CO2 catalyzed by mCA IV was 1.1 x 10(6) s-1 at pH > 9. A pKa of 6.6 was estimated for the zinc-bound water molecule in mCA IV. ..
  27. Harrison J, Jiang Y, Chen S, Xia Y, Maciejewski D, McNamara R, et al. Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia. Proc Natl Acad Sci U S A. 1998;95:10896-901 pubmed
    ..These data describe mechanisms of cellular communication between neurons and microglia, involving fractalkine and CX3CR1, which occur in both normal and pathological states of the central nervous system. ..
  28. Smith R, Szegedy M, Kucharski L, Walker C, Wiet R, Redpath A, et al. The CorA Mg2+ transport protein of Salmonella typhimurium. Mutagenesis of conserved residues in the third membrane domain identifies a Mg2+ pore. J Biol Chem. 1998;273:28663-9 pubmed
    ..We interpret the transport data to suggest that a hydroxyl group is important at Tyr307, and that these three residues interact with Mg2+ during transport, forming part of the cation pore or channel within CorA. ..
  29. Antao A, Chinchar V, McConnell T, Miller N, Clem L, Wilson M. MHC class I genes of the channel catfish: sequence analysis and expression. Immunogenetics. 1999;49:303-11 pubmed
    ..This latter finding is the first direct evidence for the cell surface association of beta2m with the MHC class I alpha chain on teleost cells and supports the notion that functional MHC class I proteins exist in teleosts...
  30. Christian J, Nakayama T. Can't get no SMADisfaction: Smad proteins as positive and negative regulators of TGF-beta family signals. Bioessays. 1999;21:382-90 pubmed
    ..Negative feedback circuits such as these play important roles in fine-tuning the activity of multifunctional signaling molecules during embryonic patterning and in response to pathologic stimuli in adults. ..
  31. Reddy G, Streck C. Variability in the 28-kDa surface antigen protein multigene locus of isolates of the emerging disease agent Ehrlichia chaffeensis suggests that it plays a role in immune evasion. Mol Cell Biol Res Commun. 1999;1:167-75 pubmed
    ..Antigenic variation could contribute to the mechanism of immune evasion and the emergence of new diseases. ..
  32. Wu J, Zhou L, Tonissen K, Tee R, Artzt K. The quaking I-5 protein (QKI-5) has a novel nuclear localization signal and shuttles between the nucleus and the cytoplasm. J Biol Chem. 1999;274:29202-10 pubmed
    ..Furthermore, using an interspecies heterokaryon assay, we found that QKI-5, but not another STAR protein ETLE, shuttles between the nucleus and the cytoplasm, which suggests that QKI-5 functions in both cell compartments...
  33. Kasof G, Prosser J, Liu D, Lorenzi M, Gomes B. The RIP-like kinase, RIP3, induces apoptosis and NF-kappaB nuclear translocation and localizes to mitochondria. FEBS Lett. 2000;473:285-91 pubmed
    ..RIP3 was localized by immunofluorescence to the mitochondrion and may play a key role in the mitochondrial disruptions often associated with apoptosis. ..
  34. Romero D, Zhou M, Gomez Sanchez C. Cloning and expression of the bovine 11beta-hydroxysteroid dehydrogenase type-2. J Steroid Biochem Mol Biol. 2000;72:231-7 pubmed
    ..In conclusion, the 11beta-HSD-2 enzyme of cattle is very similar to that of other species in its structure and enzymatic characteristics. ..
  35. Chadwick L, McCandless S, Silverman G, Schwartz S, Westaway D, Nadeau J. Betaine-homocysteine methyltransferase-2: cDNA cloning, gene sequence, physical mapping, and expression of the human and mouse genes. Genomics. 2000;70:66-73 pubmed
  36. Liu S, Lane W, Lienhard G. Cloning and preliminary characterization of a 105 kDa protein with an N-terminal kinase-like domain. Biochim Biophys Acta. 2000;1517:148-52 pubmed
    ..By immunoblotting, it was found that the protein was widely expressed in mouse tissues, and concentrated in the cytosol and low density microsome fractions of 3T3-L1 adipocytes. ..
  37. Andrews G. Cellular zinc sensors: MTF-1 regulation of gene expression. Biometals. 2001;14:223-37 pubmed
    ..Furthermore, the mouse MTF-1 gene is essential for development of the embryo, thus underscoring the importance of this transcription factor. ..
  38. Kowalski A, Graddy L, Vale Cruz D, Choi I, Katzenellenbogen B, Simmen F, et al. Molecular cloning of porcine estrogen receptor-beta complementary DNAs and developmental expression in periimplantation embryos. Biol Reprod. 2002;66:760-9 pubmed
    ..These studies taken together suggest that embryonic ER-beta likely mediates the autocrine functions of estrogens in the dynamic regulation of embryonic growth and development at periimplantation. ..
  39. Gerken T, Zhang J, Levine J, Elhammer A. Mucin core O-glycosylation is modulated by neighboring residue glycosylation status. Kinetic modeling of the site-specific glycosylation of the apo-porcine submaxillary mucin tandem repeat by UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases . J Biol Chem. 2002;277:49850-62 pubmed
  40. Blumenthal S, Clark G, Roux S. Biochemical and immunological characterization of pea nuclear intermediate filament proteins. Planta. 2004;218:965-75 pubmed
    ..This report describes the biochemical and immunological properties of these pea NIF proteins. ..
  41. Otim O, Amore G, Minokawa T, McClay D, Davidson E. SpHnf6, a transcription factor that executes multiple functions in sea urchin embryogenesis. Dev Biol. 2004;273:226-43 pubmed publisher
    ..Neither oral ectoderm regulatory functions nor ciliated band formation occur normally in the absence of hnf6 expression...
  42. Nobuta K, Okrent R, Stoutemyer M, Rodibaugh N, Kempema L, Wildermuth M, et al. The GH3 acyl adenylase family member PBS3 regulates salicylic acid-dependent defense responses in Arabidopsis. Plant Physiol. 2007;144:1144-56 pubmed
    ..Thus, our results suggest that amino acid conjugation plays a critical role in SA metabolism and induced defense responses, with PBS3 acting upstream of SA, directly on SA, or on a competitive inhibitor of SA. ..
  43. Balamurugan K, Ashokkumar B, Moussaif M, Sze J, Said H. Cloning and functional characterization of a folate transporter from the nematode Caenorhabditis elegans. Am J Physiol Cell Physiol. 2007;293:C670-81 pubmed
    ..Thus C. elegans provides a genetically tractable model that can be used to study integrative aspects of the folate uptake process in the context of the whole animal level. ..
  44. Challa M, Malladi S, Pellock B, Dresnek D, Varadarajan S, Yin Y, et al. Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease. EMBO J. 2007;26:3144-56 pubmed
    ..In summary, we demonstrate for the first time in flies that mitochondrial permeabilization not only occurs during apoptosis but also results in the release of a bona fide proapoptotic protein. ..
  45. Ni Z, Bikadi Z, Cai X, Rosenberg M, Mao Q. Transmembrane helices 1 and 6 of the human breast cancer resistance protein (BCRP/ABCG2): identification of polar residues important for drug transport. Am J Physiol Cell Physiol. 2010;299:C1100-9 pubmed publisher
    ..In conclusion, we have demonstrated the functional importance of some of these polar residues in BCRP activity...
  46. Sahin E, Jordan J, Spatara M, Naranjo A, Costanzo J, Weiss W, et al. Computational design and biophysical characterization of aggregation-resistant point mutations for ?D crystallin illustrate a balance of conformational stability and intrinsic aggregation propensity. Biochemistry. 2011;50:628-39 pubmed publisher
    ..Surprisingly, despite being the least conformationally stable, S130P was the most resistant to aggregation, indicating a significant decrease of its IAP compared to WT and M69Q. ..
  47. Hilario E, Martin F, Bertolini M, Fan L. Crystal structures of Xanthomonas small heat shock protein provide a structural basis for an active molecular chaperone oligomer. J Mol Biol. 2011;408:74-86 pubmed publisher
    ..Together, our results unravel the structural basis of an active sHsp oligomer. ..
  48. Grobosky C, Lopez J, Rennie S, Skopelitis D, Wiest A, Bingman C, et al. Structural basis of substrate specificity and selectivity of murine cytosolic 5'-nucleotidase III. J Mol Biol. 2012;423:540-54 pubmed publisher
    ..The presented substrate complex structure elucidates how cN-III achieves specificity for pyrimidine 5'-nucleotides and how it selects against purine 5'-nucleotides. ..
  49. Rosey E, Stewart G. Nucleotide and deduced amino acid sequences of the lacR, lacABCD, and lacFE genes encoding the repressor, tagatose 6-phosphate gene cluster, and sugar-specific phosphotransferase system components of the lactose operon of Streptococcus mutans. J Bacteriol. 1992;174:6159-70 pubmed
    ..mutans lac promoter appears to contain repeat elements analogous to those of S. aureus, suggesting that repression and catabolite repression of the lactose operons may be similar in these organisms...
  50. Ma J, Wang D, Chao L, Chao J. Cloning, sequence analysis and expression of the gene encoding the mouse bradykinin B2 receptor. Gene. 1994;149:283-8 pubmed
  51. Shibuya H, Nonneman D, Huang T, Ganjam V, Mann F, Johnson G. Two polymorphic microsatellites in a coding segment of the canine androgen receptor gene. Anim Genet. 1993;24:345-8 pubmed
    ..A total of seven distinct haplotypes contributed to the 13 genotypes. The 'polymorphism information content' or 'PIC' for this seven-allele X chromosome marker was 0.67. ..
  52. Chuang P, Young B, Thiagarajan R, Cornejo C, Winn R, Harlan J. Cytoplasmic domain of E-selectin contains a non-tyrosine endocytosis signal. J Biol Chem. 1997;272:24813-8 pubmed
    ..Thus, we conclude that there exists a novel non-tyrosine-containing endocytosis signal in the cytoplasmic tail which involves Ser581 and residues membrane-proximal to it. ..
  53. Pearce D, Sherman F. Differential ubiquitin-dependent degradation of the yeast apo-cytochrome c isozymes. J Biol Chem. 1997;272:31829-36 pubmed
    ..We suggest that ubiquitin-dependent degradation of apo-iso-1-cytochrome c is part of the regulatory process controlling the preferential expression of the iso-cytochromes c. ..
  54. Kayser E, Morgan P, Sedensky M. GAS-1: a mitochondrial protein controls sensitivity to volatile anesthetics in the nematode Caenorhabditis elegans. Anesthesiology. 1999;90:545-54 pubmed
    ..The hypersensitivity of animals with a mutation in the gas-1 gene may be caused by a direct anesthetic effect on a mitochondrial protein or secondary effects at other sites caused by mitochondrial dysfunction. ..
  55. Kuhn A, Li Z, Brow D. Splicing factor Prp8 governs U4/U6 RNA unwinding during activation of the spliceosome. Mol Cell. 1999;3:65-75 pubmed
    ..We propose that wild-type Prp8 triggers unwinding of U4 and U6 RNAs only after structurally correct recognition of the 5' splice site by the U6 ACAGA box and that the mutation (prp8-201) relaxes control of unwinding. ..
  56. El Bawab S, Roddy P, Qian T, Bielawska A, Lemasters J, Hannun Y. Molecular cloning and characterization of a human mitochondrial ceramidase. J Biol Chem. 2000;275:21508-13 pubmed
    ..These results demonstrate that this novel ceramidase is a mitochondrial enzyme, and they suggest the existence of a topologically restricted pathways of sphingolipid metabolism. ..
  57. Lee K, Loros J, Dunlap J. Interconnected feedback loops in the Neurospora circadian system. Science. 2000;289:107-10 pubmed
    ..The existence also of interlocked loops in Drosophila melanogaster and mouse clocks suggests that such interlocked loops may be a conserved aspect of circadian timing systems. ..
  58. Desai R, Vyas B, Earles C, Littleton J, Kowalchyck J, Martin T, et al. The C2B domain of synaptotagmin is a Ca(2+)-sensing module essential for exocytosis. J Cell Biol. 2000;150:1125-36 pubmed
    ..We propose that clustering may regulate the opening or dilation of the exocytotic fusion pore. ..
  59. Kathmann E, Naylor S, Lipsky J. Rat liver constitutive and phenobarbital-inducible cytosolic aldehyde dehydrogenases are highly homologous proteins that function as distinct isozymes. Biochemistry. 2000;39:11170-6 pubmed
    ..Furthermore, despite a high level of sequence identity and classification as a class 1 ALDH, ALDH-PB does not function like ALDH1. ALDH-PB is not merely an inducible ALDH1 isozyme; it is a distinct ALDH isozyme. ..
  60. Cavadini P, Adamec J, Taroni F, Gakh O, Isaya G. Two-step processing of human frataxin by mitochondrial processing peptidase. Precursor and intermediate forms are cleaved at different rates. J Biol Chem. 2000;275:41469-75 pubmed
    ..Thus, the second of the two processing steps catalyzed by MPP limits the levels of mature frataxin within mitochondria. ..
  61. Deng K, Shenoy S, Tso S, Yu L, Yu C. Reconstitution of mitochondrial processing peptidase from the core proteins (subunits I and II) of bovine heart mitochondrial cytochrome bc(1) complex. J Biol Chem. 2001;276:6499-505 pubmed
    ..The aromatic group, rather than the hydroxyl group, at Tyr(57) of core I is essential for reconstitutive activity. ..
  62. Sung D, Vierling E, Guy C. Comprehensive expression profile analysis of the Arabidopsis Hsp70 gene family. Plant Physiol. 2001;126:789-800 pubmed
  63. Fei Y, Inoue K, Ganapathy V. Structural and functional characteristics of two sodium-coupled dicarboxylate transporters (ceNaDC1 and ceNaDC2) from Caenorhabditis elegans and their relevance to life span. J Biol Chem. 2003;278:6136-44 pubmed
    ..elegans may lead to decreased availability of dicarboxylates for cellular production of metabolic energy, thus creating a biological state similar to that of caloric restriction, and consequently leading to life span extension. ..
  64. Amanna I, Dingwall J, Hayes C. Enforced bcl-xL gene expression restored splenic B lymphocyte development in BAFF-R mutant mice. J Immunol. 2003;170:4593-600 pubmed
    ..We conclude that the mutant A/WySnJ allele of Tnfrsf13c can be complemented through the survival signal provided by Bcl-x(L). ..
  65. Johnson K, Johnson K, Becker K, Bielawski J, Mao C, Obeid L. Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability. J Biol Chem. 2003;278:34541-7 pubmed
    ..Collectively, these data suggest that regulation of hSPPase1 with the resultant changes in cellular and secreted S1P could have important implications to cell proliferation, angiogenesis, and apoptosis. ..
  66. Pattee P, Ilie A, Benyhe S, Toth G, Borsodi A, Nagalla S. Cloning and characterization of Xen-dorphin prohormone from Xenopus laevis: a new opioid-like prohormone distinct from proenkephalin and prodynorphin. J Biol Chem. 2003;278:53098-104 pubmed
    ..Cloning of the Xen-dorphin prohormone provides new evidence for the potential presence of other members in the opioid peptide superfamily. ..
  67. Mamidipudi V, Lin C, Seibenhener M, Wooten M. Regulation of interleukin receptor-associated kinase (IRAK) phosphorylation and signaling by iota protein kinase C. J Biol Chem. 2004;279:4161-5 pubmed
    ..These findings provide insight into the underlying mechanism whereby IRAK regulates the kappaB pathway and reveal that IRAK is a substrate of iota PKC. ..
  68. Nekrutenko A, Wadhawan S, Goetting Minesky P, Makova K. Oscillating evolution of a mammalian locus with overlapping reading frames: an XLalphas/ALEX relay. PLoS Genet. 2005;1:e18 pubmed
    ..This is the first example of a rapidly evolving locus encoding interacting proteins via overlapping reading frames, with a possible link to the origin of species-specific neurological differences. ..
  69. Polevoda B, Span L, Sherman F. The yeast translation release factors Mrf1p and Sup45p (eRF1) are methylated, respectively, by the methyltransferases Mtq1p and Mtq2p. J Biol Chem. 2006;281:2562-71 pubmed
    ..Most interestingly, the mtq2-Delta was significantly more resistant to the anti-microtubule drugs thiabendazole and benomyl, suggesting that Mtq2p may also methylate certain microtubule-related proteins. ..
  70. Sang Y, Patil A, Zhang G, Ross C, Blecha F. Bioinformatic and expression analysis of novel porcine beta-defensins. Mamm Genome. 2006;17:332-9 pubmed
    ..These findings establish the existence of multiple porcine beta-defensins and suggest that the pig may be an ideal model for the characterization of beta-defensin diversity and function. ..
  71. Dabbeekeh J, Faitar S, Dufresne C, Cowell J. The EVI5 TBC domain provides the GTPase-activating protein motif for RAB11. Oncogene. 2007;26:2804-8 pubmed
  72. Park P, Sapra K, Koliński M, Filipek S, Palczewski K, Muller D. Stabilizing effect of Zn2+ in native bovine rhodopsin. J Biol Chem. 2007;282:11377-85 pubmed
    ..The inclusion of ZnCl2 in SMFS assay buffer increased the stability of most structural segments. This effect was not mimicked by CaCl2, CdCl2, or CoCl2. Thus, Zn2+ stabilizes the structure of rhodopsin in a specific manner. ..
  73. Hurst K, Koetzner C, Masters P. Identification of in vivo-interacting domains of the murine coronavirus nucleocapsid protein. J Virol. 2009;83:7221-34 pubmed publisher
    ..The other is domain N1b, which corresponds to the N-terminal domain that has been structurally characterized in detail for two other coronaviruses, infectious bronchitis virus and the severe acute respiratory syndrome coronavirus...
  74. Terzulli A, Kosman D. Analysis of the high-affinity iron uptake system at the Chlamydomonas reinhardtii plasma membrane. Eukaryot Cell. 2010;9:815-26 pubmed publisher
    ..Last, recombinant FOX1 (rFOX1) has been isolated in a partially holo form that exhibits the UV-visible absorbance spectrum of a multicopper oxidase and the catalytic activity of a ferroxidase. ..
  75. Olucha J, Lamb A. Mechanistic and structural studies of the N-hydroxylating flavoprotein monooxygenases. Bioorg Chem. 2011;39:171-7 pubmed publisher
    ..This includes summaries of steady and transient state kinetic data for all three enzymes and the X-ray crystallographic structure of PvdA. ..
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