Experts and Doctors on amino acid sequence in Switzerland


Locale: Switzerland
Topic: amino acid sequence

Top Publications

  1. Schmid D, Jaussi R, Christen P. Precursor of mitochondrial aspartate aminotransferase synthesized in Escherichia coli is complexed with heat-shock protein DnaK. Eur J Biochem. 1992;208:699-704 pubmed
    ..No complex was formed with mAspAT. Apparently, DnaK binds to the solvent-exposed presequence of folded pmAspAT without significantly changing the structure and functional properties of its mature moiety. ..
  2. Van Slooten J, Bhuvanasvari T, Bardin S, Stanley J. Two C4-dicarboxylate transport systems in Rhizobium sp. NGR234: rhizobial dicarboxylate transport is essential for nitrogen fixation in tropical legume symbioses. Mol Plant Microbe Interact. 1992;5:179-86 pubmed
  3. Verrey F, Kairouz P, Schaerer E, Fuentes P, Geering K, Rossier B, et al. Primary sequence of Xenopus laevis Na+-K+-ATPase and its localization in A6 kidney cells. Am J Physiol. 1989;256:F1034-43 pubmed
    ..The alpha- and the beta-subunits of Na+-K+-ATPase were found associated early in the course of biosynthesis and were restricted to the basolateral plasma membrane...
  4. Hein W, Dudler L. Divergent evolution of T cell repertoires: extensive diversity and developmentally regulated expression of the sheep gamma delta T cell receptor. EMBO J. 1993;12:715-24 pubmed
  5. Munn A, Stevenson B, Geli M, Riezman H. end5, end6, and end7: mutations that cause actin delocalization and block the internalization step of endocytosis in Saccharomyces cerevisiae. Mol Biol Cell. 1995;6:1721-42 pubmed
    ..We propose that Vrp1p, Rvs161p, and Rvs167p are components of a cytoskeletal structure that contains actin and fimbrin and that is required for formation of endocytic vesicles at the plasma membrane. ..
  6. Henchoz S, De Rubertis F, Pauli D, Spierer P. The dose of a putative ubiquitin-specific protease affects position-effect variegation in Drosophila melanogaster. Mol Cell Biol. 1996;16:5717-25 pubmed
    ..Ubps can cleave the ubiquitin part from these proteins. We discuss the link established here between a deubiquitinating enzyme and epigenetic silencing processes. ..
  7. Hanin M, Jabbouri S, Quesada Vincens D, Freiberg C, Perret X, Prom J, et al. Sulphation of Rhizobium sp. NGR234 Nod factors is dependent on noeE, a new host-specificity gene. Mol Microbiol. 1997;24:1119-29 pubmed
    ..Together, these findings show that noeE is a host-specificity gene which probably encodes a fucose-specific sulphotransferase...
  8. Borggrefe T, Wabl M, Akhmedov A, Jessberger R. A B-cell-specific DNA recombination complex. J Biol Chem. 1998;273:17025-35 pubmed
    ..These findings are consistent with SWAP being the long elusive "switch recombinase" and with SWAP-70 being the specific recruiting element that assembles the switch recombinase from universal components. ..
  9. Vogel G, Aeschbacher R, Muller J, Boller T, Wiemken A. Trehalose-6-phosphate phosphatases from Arabidopsis thaliana: identification by functional complementation of the yeast tps2 mutant. Plant J. 1998;13:673-83 pubmed
    ..The finding of these novel Arabidopsis genes for trehalose-6-phosphate phosphatase strongly indicates that a pathway for trehalose biosynthesis exists in plants. ..

More Information

Publications287 found, 100 shown here

  1. Groppe J, Rumpel K, Economides A, Stahl N, Sebald W, Affolter M. Biochemical and biophysical characterization of refolded Drosophila DPP, a homolog of bone morphogenetic proteins 2 and 4. J Biol Chem. 1998;273:29052-65 pubmed
  2. Desiere F, Pridmore R, Brussow H. Comparative genomics of the late gene cluster from Lactobacillus phages. Virology. 2000;275:294-305 pubmed
    ..The tree suggested that the ClpP-like proteins from the phages were not acquired by horizontal gene transfer from their corresponding bacterial hosts. ..
  3. Mery L, Magnino F, Schmidt K, Krause K, Dufour J. Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors. FEBS Lett. 2001;487:377-83 pubmed
    ..Thus, we describe a novel interaction between Trp proteins and InsP3R and we provide evidence suggesting that the formation of hTrp4-InsP3R complexes may be regulated by alternative splicing. ..
  4. Naula C, Schaub R, Leech V, Melville S, Seebeck T. Spontaneous dimerization and leucine-zipper induced activation of the recombinant catalytic domain of a new adenylyl cyclase of Trypanosoma brucei, GRESAG4.4B. Mol Biochem Parasitol. 2001;112:19-28 pubmed
    ..The LZ appears to enforce a distinct conformation of the dimer, which leads to an increased enzymatic activity, and thus may mimic the effect of ligand-induced dimerization of adenylyl cyclase in vivo. ..
  5. Taylor S, Walter K, Kast P, Hilvert D. Searching sequence space for protein catalysts. Proc Natl Acad Sci U S A. 2001;98:10596-601 pubmed
  6. Daigle I, Yousefi S, Colonna M, Green D, Simon H. Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils. Nat Med. 2002;8:61-7 pubmed
    ..Thus, we provide molecular and functional evidence for negative signaling by death receptors. ..
  7. Niermann T, Schmutz S, Erne P, Resink T. Aryl hydrocarbon receptor ligands repress T-cadherin expression in vascular smooth muscle cells. Biochem Biophys Res Commun. 2003;300:943-9 pubmed
    ..Regulation of adhesion proteins through the AHR pathway may represent a novel mechanism of action by atherogenic polycyclic aromatic hydrocarbons. ..
  8. Müller T, Werlen C, Spain J, van der Meer J. Evolution of a chlorobenzene degradative pathway among bacteria in a contaminated groundwater mediated by a genomic island in Ralstonia. Environ Microbiol. 2003;5:163-73 pubmed
  9. Bättig P, Saudan P, Gunde T, Bachmann M. Enhanced apoptotic activity of a structurally optimized form of galectin-1. Mol Immunol. 2004;41:9-18 pubmed
    ..This structurally optimized form of galectin-1 may therefore be a potentially powerful tool to treat chronic inflammatory diseases. ..
  10. Petkovic V, Moghini C, Paoletti S, Uguccioni M, Gerber B. I-TAC/CXCL11 is a natural antagonist for CCR5. J Leukoc Biol. 2004;76:701-8 pubmed
  11. Regeard C, Maillard J, Dufraigne C, Deschavanne P, Holliger C. Indications for acquisition of reductive dehalogenase genes through horizontal gene transfer by Dehalococcoides ethenogenes strain 195. Appl Environ Microbiol. 2005;71:2955-61 pubmed
    ..A hierarchical classification of the atypical regions containing the reductive dehalogenase genes indicated that these regions were probably acquired by several gene transfer events...
  12. Leger B, Vergani L, Sorarù G, Hespel P, Derave W, Gobelet C, et al. Human skeletal muscle atrophy in amyotrophic lateral sclerosis reveals a reduction in Akt and an increase in atrogin-1. FASEB J. 2006;20:583-5 pubmed
    ..The transcriptional regulation of human atrogin-1 may be controlled by an Akt-mediated transcription factor other than FKHR or via another signaling pathway. ..
  13. Hergovich A, Lisztwan J, Thoma C, Wirbelauer C, Barry R, Krek W. Priming-dependent phosphorylation and regulation of the tumor suppressor pVHL by glycogen synthase kinase 3. Mol Cell Biol. 2006;26:5784-96 pubmed
  14. Seeger M, von Ballmoos C, Verrey F, Pos K. Crucial role of Asp408 in the proton translocation pathway of multidrug transporter AcrB: evidence from site-directed mutagenesis and carbodiimide labeling. Biochemistry. 2009;48:5801-12 pubmed publisher
    ..This study provides evidence for a substantial role of membrane-located carboxylates as a central element of the proton translocation pathway in AcrB and other members of the RND superfamily. ..
  15. Nuber N, Curioni Fontecedro A, Matter C, Soldini D, Tiercy J, von Boehmer L, et al. Fine analysis of spontaneous MAGE-C1/CT7-specific immunity in melanoma patients. Proc Natl Acad Sci U S A. 2010;107:15187-92 pubmed publisher
    ..This study shows that CT7 can induce specific cellular immunity in melanoma patients. Based on these findings, CT7 will be further explored as a potential vaccine for melanoma immunotherapy. ..
  16. Seebeck T, Sterk G, Ke H. Phosphodiesterase inhibitors as a new generation of antiprotozoan drugs: exploiting the benefit of enzymes that are highly conserved between host and parasite. Future Med Chem. 2011;3:1289-306 pubmed publisher
    ..Given the high degree of structural similarity between the human and the protozoan PDEs, the vast expertise available in the human field can now be applied to developing disease-specific PDE inhibitors as new antiprotozoan drugs. ..
  17. Wu X, Gehring W. Cellular uptake of the Antennapedia homeodomain polypeptide by macropinocytosis. Biochem Biophys Res Commun. 2014;443:1136-40 pubmed publisher
    ..Our results identify macropinocytosis as a major mechanism by which Antennapedia homeodomain obtains the access to the interior of cells, providing a novel perspective in the field of protein translocation and transduction. ..
  18. Silva S, Homolka D, Pillai R. Characterization of the mammalian RNA exonuclease 5/NEF-sp as a testis-specific nuclear 3' ? 5' exoribonuclease. RNA. 2017;23:1385-1392 pubmed publisher
    ..Taken together, our study provides the first biochemical and genetic exploration of the role of the NEF-sp exoribonuclease in the mammalian genome. ..
  19. Wahle E, Martin G, Schiltz E, Keller W. Isolation and expression of cDNA clones encoding mammalian poly(A) polymerase. EMBO J. 1991;10:4251-7 pubmed
    ..3 kb. The sequence of the N-terminal half of bovine poly(A) polymerase is 47% identical with the amino acid sequence of the corresponding part of yeast poly(A) polymerase. Homologies to other proteins are of uncertain significance. ..
  20. Favre D, Cryz S, Viret J. Cloning of the recA gene of Bordetella pertussis and characterization of its product. Biochimie. 1991;73:235-44 pubmed
    ..Amino acid sequence comparisons revealed a high degree of structural conservation between prokaryotic RecA proteins. ..
  21. Aebi M, Fah J, Hurt N, Samuel C, Thomis D, Bazzigher L, et al. cDNA structures and regulation of two interferon-induced human Mx proteins. Mol Cell Biol. 1989;9:5062-72 pubmed
    ..In contrast to mouse Mx1 protein, which accumulates in the nuclei of IFN-treated mouse cells, the two human Mx proteins both accumulate in the cytoplasm of IFN-treated cells. ..
  22. Berchtold M. Parvalbumin genes from human and rat are identical in intron/exon organization and contain highly homologous regulatory elements and coding sequences. J Mol Biol. 1989;210:417-27 pubmed
    ..A 700-nucleotide long parvalbumin mRNA is synthesized at low levels in the human cerebellum as well as in the neuroblastoma cell line SK-N-BE. ..
  23. Corbett M, Schmitt I, Riess O, Walz A. Characterization of the gene for human neutrophil-activating peptide 78 (ENA-78). Biochem Biophys Res Commun. 1994;205:612-7 pubmed
    ..The 5' flanking region contains potential binding sites for several nuclear factors such as AP-2, NF-kappa B, and interferon regulatory factor-1. ..
  24. Buhr A, Flükiger K, Erni B. The glucose transporter of Escherichia coli. Overexpression, purification, and characterization of functional domains. J Biol Chem. 1994;269:23437-43 pubmed
    ..Eberstadt, M., Gemmecker, G., Kessler, H., Buhr, A., and Erni, B. (1994) Eur. J. Biochem. 219, 945-952). ..
  25. Bridgen A, Duarte M, Tobler K, Laude H, Ackermann M. Sequence determination of the nucleocapsid protein gene of the porcine epidemic diarrhoea virus confirms that this virus is a coronavirus related to human coronavirus 229E and porcine transmissible gastroenteritis virus. J Gen Virol. 1993;74 ( Pt 9):1795-804 pubmed publisher
    ..Several RNA motifs typical of coronaviruses were also observed. These results confirm the earlier provisional classification of PEDV as a coronavirus...
  26. Hasler T, Rader C, Stoeckli E, Zuellig R, Sonderegger P. cDNA cloning, structural features, and eucaryotic expression of human TAG-1/axonin-1. Eur J Biochem. 1993;211:329-39 pubmed
    ..An additional shared feature of human TAG-1/axonin-1, rat TAG-1 and chick axonin-1 is their attachment to the cell membrane with a glycosyl-PtdIns anchor. ..
  27. Burnens A, Stucki U, Nicolet J, Frey J. Identification and characterization of an immunogenic outer membrane protein of Campylobacter jejuni. J Clin Microbiol. 1995;33:2826-32 pubmed
    ..jejuni and is highly immunogenic. It is therefore a good candidate as an antigen for the serological diagnosis of past C. jejuni infections...
  28. Spaniol P, Bornmann C, Hauptmann G, Gerster T. Class III POU genes of zebrafish are predominantly expressed in the central nervous system. Nucleic Acids Res. 1996;24:4874-81 pubmed
    ..Analysis of the expression of the class III genes shows that they are predominantly expressed in the central nervous system and that they may play important roles in patterning the embryonic brain. ..
  29. Polgar J, Clemetson J, Kehrel B, Wiedemann M, Magnenat E, Wells T, et al. Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor. J Biol Chem. 1997;272:13576-83 pubmed
  30. Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, et al. Inhibition of death receptor signals by cellular FLIP. Nature. 1997;388:190-5 pubmed
    ..High levels of FLIP(L) protein are also detectable in melanoma cell lines and malignant melanoma tumours. Thus FLIP may be implicated in tissue homeostasis as an important regulator of apoptosis. ..
  31. Marazzi S, Blum S, Hartmann R, Gundersen D, Schreyer M, Argraves S, et al. Characterization of human fibroleukin, a fibrinogen-like protein secreted by T lymphocytes. J Immunol. 1998;161:138-47 pubmed
    ..While the exact function of fibroleukin remains to be defined, these data suggest that fibroleukin may play a role in physiologic lymphocyte functions at mucosal sites. ..
  32. Storici P, Capitani G, De Biase D, Moser M, John R, Jansonius J, et al. Crystal structure of GABA-aminotransferase, a target for antiepileptic drug therapy. Biochemistry. 1999;38:8628-34 pubmed
    ..The aldimines of GABA and the antiepileptic drug vinyl-GABA have been modeled into the active site. ..
  33. Zhang H, Cowan Jacob S, Simonen M, Greenhalf W, Heim J, Meyhack B. Structural basis of BFL-1 for its interaction with BAX and its anti-apoptotic action in mammalian and yeast cells. J Biol Chem. 2000;275:11092-9 pubmed
    ..e. a hydrophobic pocket for the binding of proapoptotic proteins, rather than extended sequence homologies. ..
  34. Schulz H, Pellicioli E, Thony Meyer L. New insights into the role of CcmC, CcmD and CcmE in the haem delivery pathway during cytochrome c maturation by a complete mutational analysis of the conserved tryptophan-rich motif of CcmC. Mol Microbiol. 2000;37:1379-88 pubmed
    ..We propose that the three membrane proteins CcmC, CcmD and CcmE interact directly with each other, establishing a cytoplasm to periplasm haem delivery pathway for cytochrome c maturation. ..
  35. Stetefeld J, Jenny M, Schulthess T, Landwehr R, Schumacher B, Frank S, et al. The laminin-binding domain of agrin is structurally related to N-TIMP-1. Nat Struct Biol. 2001;8:705-9 pubmed
    ..A high structural similarity of NtA with the protease inhibition domain in tissue inhibitor of metalloproteinases-1 (TIMP-1) supports the idea of additional functions of agrin besides synaptogenic activity. ..
  36. Johner A, Lanzrein B. Characterization of two genes of the polydnavirus of Chelonus inanitus and their stage-specific expression in the host Spodoptera littoralis. J Gen Virol. 2002;83:1075-85 pubmed
    ..These are the first data to show strong upregulation of polydnavirus genes towards the end of parasitization. These two genes might be involved in the reduction of host ecdysteroids observed at this stage. ..
  37. Ostermann N, Eder J, Eidhoff U, Zink F, Hassiepen U, Worpenberg S, et al. Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor. J Mol Biol. 2006;355:249-61 pubmed
  38. Kundig T, Senti G, Schnetzler G, Wolf C, Prinz Vavricka B, Fulurija A, et al. Der p 1 peptide on virus-like particles is safe and highly immunogenic in healthy adults. J Allergy Clin Immunol. 2006;117:1470-6 pubmed
    ..In this study we covalently coupled a synthetic 16-amino-acid sequence of the allergen Der p 1 to a virus-like particle derived from the bacteriophage Qbeta (Qbeta-Der p 1)...
  39. Merz T, Wetzel S, Firbank S, Plückthun A, Grutter M, Mittl P. Stabilizing ionic interactions in a full-consensus ankyrin repeat protein. J Mol Biol. 2008;376:232-40 pubmed
    ..Ankyrins can therefore use design principles from proteins of thermophilic organisms and reach at least similar stabilities. ..
  40. Haeuptle M, Pujol F, Neupert C, Winchester B, Kastaniotis A, Aebi M, et al. Human RFT1 deficiency leads to a disorder of N-linked glycosylation. Am J Hum Genet. 2008;82:600-6 pubmed publisher
    ..RFT1 deficiency in both yeast and human cells leads to the accumulation of incomplete DolPP-GlcNAc(2)Man(5) and to a profound glycosylation disorder in humans. ..
  41. Campagne S, Marsh M, Capitani G, Vorholt J, Allain F. Structural basis for -10 promoter element melting by environmentally induced sigma factors. Nat Struct Mol Biol. 2014;21:269-76 pubmed publisher
    ..This mechanism of promoter melting explains the increased promoter-selection stringency of environmentally induced sigma factors. ..
  42. Pepper M, Belin D, Montesano R, Orci L, Vassalli J. Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro. J Cell Biol. 1990;111:743-55 pubmed
  43. Kueng V, Schlaeppi K, Schneider A, Seebeck T. A glycosomal protein (p60) which is predominantly expressed in procyclic Trypanosoma brucei. Characterization and DNA sequence. J Biol Chem. 1989;264:5203-9 pubmed
    ..The biological role of the microtubule-binding capability of p60 remains unclear, whereas its membrane binding may be of physiological significance inside the glycosome. ..
  44. Flor P, Lindauer K, Püttner I, Ruegg D, Lukic S, Knopfel T, et al. Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2. Eur J Neurosci. 1995;7:622-9 pubmed
    ..R,S)-alpha-methyl-4-carboxyphenylglycine, a reported antagonist at some mGluR subtypes, reduced the depression of forskolin-induced cAMP accumulation by (1S,3R)-ACPD in both human and rat mGluR2. ..
  45. Jenny A, Hauri H, Keller W. Characterization of cleavage and polyadenylation specificity factor and cloning of its 100-kilodalton subunit. Mol Cell Biol. 1994;14:8183-90 pubmed
    ..Immunofluorescent detection of CPSF in HeLa cells localized it in the nucleoplasm, excluding cytoplasm and nucleolar structures. ..
  46. Bolliger L, Deloche O, Glick B, Georgopoulos C, Jeno P, Kronidou N, et al. A mitochondrial homolog of bacterial GrpE interacts with mitochondrial hsp70 and is essential for viability. EMBO J. 1994;13:1998-2006 pubmed
    ..Yeast GrpEp is made as a precursor that is cleaved upon import into isolated mitochondria. GrpEp is essential for viability. We suggest that this protein interacts with mhsp70 in a manner analogous to that of GrpE with DnaK of E.coli. ..
  47. Seum C, Spierer A, Pauli D, Szidonya J, Reuter G, Spierer P. Position-effect variegation in Drosophila depends on dose of the gene encoding the E2F transcriptional activator and cell cycle regulator. Development. 1996;122:1949-56 pubmed
    ..A link is established here, and discussed, between the dose of a transcriptional activator, which controls the cell cycle, and epigenetic silencing of chromosomal domains in Drosophila. ..
  48. Solioz M, Vulpe C. CPx-type ATPases: a class of P-type ATPases that pump heavy metals. Trends Biochem Sci. 1996;21:237-41 pubmed
    ..We propose to call these enzymes CPx-type ATPases, based on the common novel feature of a conserved intramembranous cysteine-proline-cysteine or cysteine-proline-histidine motif. ..
  49. Fischer R, Wei Y, Anagli J, Berchtold M. Calmodulin binds to and inhibits GTP binding of the ras-like GTPase Kir/Gem. J Biol Chem. 1996;271:25067-70 pubmed
    ..These results suggest the existence of a direct link between Ca2+/CaM and growth factor signal transduction pathways at the level of small Ras-like GTPases. ..
  50. Campbell K, Giorda R. The cytoplasmic domain of rat NKR-P1 receptor interacts with the N-terminal domain of p56(lck) via cysteine residues. Eur J Immunol. 1997;27:72-7 pubmed
    ..This could reflect a higher activation threshold for the NKR-P1 and CD8 receptors, which are involved in cytolytic responses, compared to CD4 which is involved in T cell helper function. ..
  51. Warth R, Briand P, Picard D. Functional analysis of the yeast 40 kDa cyclophilin Cyp40 and its role for viability and steroid receptor regulation. Biol Chem. 1997;378:381-91 pubmed
    ..While other immunophilins could conceivably compensate a Cyp40 defect, our results are compatible with the notion that immunophilins may be fortuitous partners in the biochemically established steroid receptor-Hsp90 complex. ..
  52. Baumeister A, Arber S, Caroni P. Accumulation of muscle ankyrin repeat protein transcript reveals local activation of primary myotube endcompartments during muscle morphogenesis. J Cell Biol. 1997;139:1231-42 pubmed
  53. Doucey M, Hess D, Blommers M, Hofsteenge J. Recombinant human interleukin-12 is the second example of a C-mannosylated protein. Glycobiology. 1999;9:435-41 pubmed
    ..However, the occurrence of the C-mannosyltransferase activity in a variety of cells and tissues, and the presence of the recognition motif in many proteins indicate that more C-mannosylated proteins may be found. ..
  54. Scherer Oppliger T, Leimbacher W, Blau N, Thony B. Serine 19 of human 6-pyruvoyltetrahydropterin synthase is phosphorylated by cGMP protein kinase II. J Biol Chem. 1999;274:31341-8 pubmed
    ..These results suggest that Ser(19) of human PTPS may be a substrate for cGKII phosphorylation also in vivo, a modification that is essential for normal activity. ..
  55. Kües U. Life history and developmental processes in the basidiomycete Coprinus cinereus. Microbiol Mol Biol Rev. 2000;64:316-53 pubmed
    ..The isolation of genes for potential non-DNA methyltransferases, needed for tissue formation within the fruiting body, promises the discovery of new signaling pathways, possibly involving secondary fungal metabolites...
  56. Sciotti M, Nakajin S, Wermuth B, Baker M. Mutation of threonine-241 to proline eliminates autocatalytic modification of human carbonyl reductase. Biochem J. 2000;350 Pt 1:89-92 pubmed
    ..We propose that integrity of this local environment is essential for chemical modification of lysine-239, but not absolutely required for carbonyl reductase activity. ..
  57. Bost S, Silva F, Rudaz C, Belin D. Both transmembrane domains of SecG contribute to signal sequence recognition by the Escherichia coli protein export machinery. Mol Microbiol. 2000;38:575-87 pubmed
    ..Thus, SecG participates in signal sequence recognition, and both transmembrane domains of SecG contribute to ensure normal signal sequence recognition by the translocase. ..
  58. Pooggin M, Futterer J, Skryabin K, Hohn T. Ribosome shunt is essential for infectivity of cauliflower mosaic virus. Proc Natl Acad Sci U S A. 2001;98:886-91 pubmed
    ..Finally, by using an artificial stem structure that blocks scanning, we obtained direct evidence that ribosome shunt operates during CaMV infection...
  59. Romero Isart N, Jensen L, Zerbe O, Winge D, Vasak M. Engineering of metallothionein-3 neuroinhibitory activity into the inactive isoform metallothionein-1. J Biol Chem. 2002;277:37023-8 pubmed
    ..The functional significance of such heterogeneous cluster ensemble is discussed. ..
  60. Micheau O, Thome M, Schneider P, Holler N, Tschopp J, Nicholson D, et al. The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex. J Biol Chem. 2002;277:45162-71 pubmed
  61. Lacazette E, Le Calvez S, Gajendran N, Brenner H. A novel pathway for MuSK to induce key genes in neuromuscular synapse formation. J Cell Biol. 2003;161:727-36 pubmed
    ..The same pathways are used to regulate synaptic expression of AChR epsilon. We propose that the novel pathway stabilizes the synapse early in development, whereas the NRG/ErbB pathway supports maintenance of the mature synapse. ..
  62. Paganetti P, Calanca V, Galli C, Stefani M, Molinari M. beta-site specific intrabodies to decrease and prevent generation of Alzheimer's Abeta peptide. J Cell Biol. 2005;168:863-8 pubmed
  63. Sperisen P, Schmid C, Bucher P, Zilian O. Stealth proteins: in silico identification of a novel protein family rendering bacterial pathogens invisible to host immune defense. PLoS Comput Biol. 2005;1:e63 pubmed publisher
    ..At a more basic level, the characterization of the molecular and cellular function of Stealth proteins may shed light on fundamental mechanisms of innate immune defense against microbial invasion...
  64. Saydam O, Steiner F, Vogt B, Schwyzer M. Host cell targets of immediate-early protein BICP22 of bovine herpesvirus 1. Vet Microbiol. 2006;113:185-92 pubmed
    ..Upon amplicon transduction of Vero cells and plasmid transfection, CREBL2 and ZNF38 both colocalized with BICP22 in distinct nuclear domains. ..
  65. Michalik L, Zoete V, Krey G, Grosdidier A, Gelman L, Chodanowski P, et al. Combined simulation and mutagenesis analyses reveal the involvement of key residues for peroxisome proliferator-activated receptor alpha helix 12 dynamic behavior. J Biol Chem. 2007;282:9666-77 pubmed
    ..Substitution of these residues suppresses PPARalpha constitutive activity, without changing PPARalpha ligand-dependent activation potential. ..
  66. Macagno A, Bernasconi N, Vanzetta F, Dander E, Sarasini A, Revello M, et al. Isolation of human monoclonal antibodies that potently neutralize human cytomegalovirus infection by targeting different epitopes on the gH/gL/UL128-131A complex. J Virol. 2010;84:1005-13 pubmed publisher
  67. Polkinghorne A, Vaughan L. Chlamydia abortus YhbZ, a truncated Obg family GTPase, associates with the Escherichia coli large ribosomal subunit. Microb Pathog. 2011;50:200-6 pubmed publisher
    ..coli obgE temperature-sensitive mutant, indicating the C-terminal acidic domain may have an additional role. This data supports a role for YhbZ linking the chlamydial stress response to ribosome function and cellular growth. ..
  68. Blyszczuk P, Berthonneche C, Behnke S, Glönkler M, Moch H, Pedrazzini T, et al. Nitric oxide synthase 2 is required for conversion of pro-fibrogenic inflammatory CD133(+) progenitors into F4/80(+) macrophages in experimental autoimmune myocarditis. Cardiovasc Res. 2013;97:219-29 pubmed publisher
    ..Modulating the in vivo differentiation fate of specific progenitors might become a novel approach for the treatment of inflammatory heart diseases. ..
  69. Sacconnay L, Smirlis D, Queiroz E, Wolfender J, Soares M, Carrupt P, et al. Structural insights of SIR2rp3 proteins as promising biotargets to fight against Chagas disease and leishmaniasis. Mol Biosyst. 2013;9:2223-30 pubmed publisher
    ..On the other hand, by extending the analysis to the channel rims, regions of difference between host and parasitic targets, useful for future selective drug design projects, were pointed out. ..
  70. Heitman J, Movva N, Hall M. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science. 1991;253:905-9 pubmed
    ..Such a complex may mediate nuclear entry of signals required for progression through the cell cycle. ..
  71. Maridor G, Krek W, Nigg E. Structure and developmental expression of chicken nucleolin and NO38: coordinate expression of two abundant non-ribosomal nucleolar proteins. Biochim Biophys Acta. 1990;1049:126-33 pubmed
    ..From these results we conclude, first, that the expression of nucleolin and NO38 is controlled coordinately, and, second, that regulation is likely to involve both transcriptional and posttranscriptional mechanisms. ..
  72. Muller M, Ruppert S, Schaffner W, Matthias P. A cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells. Nature. 1988;336:544-51 pubmed
    ..The nucleotide sequence shows homology to the homoeobox domain. Expression of this cDNA in HeLa cells is sufficient for a strong transcriptional activation of B-cell-specific promoters. ..
  73. Irminger Finger I, Nothiger R. The Drosophila melanogaster gene lethal(3)73Ah encodes a ring finger protein homologous to the oncoproteins MEL-18 and BMI-1. Gene. 1995;163:203-8 pubmed
    ..Its transcription is temporally and spatially regulated with maximal expression in adult females. In all stages the mRNA can be localized to the fat body and, in addition, to the ovaries of adult females. ..
  74. Pott U, Thiesen H, Colello R, Schwab M. A new Cys2/His2 zinc finger gene, rKr2, is expressed in differentiated rat oligodendrocytes and encodes a protein with a functional repressor domain. J Neurochem. 1995;65:1955-66 pubmed
  75. Verri T, Markovich D, Perego C, Norbis F, Stange G, Sorribas V, et al. Cloning of a rabbit renal Na-Pi cotransporter, which is regulated by dietary phosphate. Am J Physiol. 1995;268:F626-33 pubmed
    ..Thus rabbit proximal tubular BBMs contain two different Na-Pi cotransport systems: NaPi-1 (type I) and NaPi-6 (type II). Only the type II transport system seems to be under regulatory control in response to low-Pi dietary intake...
  76. Meier P, Koedood M, Philipp J, Fontana A, Mitchell P. Alternative mRNAs encode multiple isoforms of transcription factor AP-2 during murine embryogenesis. Dev Biol. 1995;169:1-14 pubmed
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