Genomes and Genes
Experts and Doctors on amino acid sequence in Germany
Topic: amino acid sequence
Publications633 found, 100 shown here
- Hartlieb B, Modrof J, M hlberger E, Klenk H, Becker S. Oligomerization of Ebola virus VP30 is essential for viral transcription and can be inhibited by a synthetic peptide. J Biol Chem. 2003;278:41830-6 pubmed publisher..When E30pep-wt was transfected into EBOV-infected cells, the peptide inhibited viral replication suggesting that inhibition of VP30 oligomerization represents a target for EBOV antiviral drugs...
- Huemmerich D, Helsen C, Quedzuweit S, Oschmann J, Rudolph R, Scheibel T. Primary structure elements of spider dragline silks and their contribution to protein solubility. Biochemistry. 2004;43:13604-12 pubmed
- Galliano H, Cabane M, Eckerskorn C, Lottspeich F, Sandermann H, Ernst D. Molecular cloning, sequence analysis and elicitor-/ozone-induced accumulation of cinnamyl alcohol dehydrogenase from Norway spruce (Picea abies L.). Plant Mol Biol. 1993;23:145-56 pubmed..7% and 91.5%, respectively. Treatment of spruce cell cultures with elicitor, as well as of seedlings with ozone both markedly increased the CAD mRNA level. ..
- Kuhlmann J, Scheit K. Characterization of the gene for seminalplasmin, a secretory protein of the bovine seminal vesicle. Biochim Biophys Acta. 1993;1173:85-6 pubmed..1 kb is organized in four exons and three introns. Regulatory sequences involved in regulation of transcription could not be identified by simple sequence homologies. A putative promoter element TATAA is located 29 bp upstream of exon 1. ..
- Bechinger B. Structure and functions of channel-forming peptides: magainins, cecropins, melittin and alamethicin. J Membr Biol. 1997;156:197-211 pubmed
- Schneikert J, Hubner S, Martin E, Cato A. A nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activity. J Cell Biol. 1999;146:929-40 pubmed..These studies identify the [EEX(4)](8) sequence as a signature motif for inhibition of GR-mediated transactivation and demonstrate a specific nuclear action of a eukaryotic cochaperone in the regulation of GR activity. ..
- Altincicek B, Tenbaum S, Dressel U, Thormeyer D, Renkawitz R, Baniahmad A. Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita. J Biol Chem. 2000;275:7662-7 pubmed..Interestingly, a novel adrenal gland-specific mRNA of Alien was discovered. Thus, the impairment of Alien binding seems to play an important role in the pathogenesis mediated by DAX-1 mutants. ..
- Bethe G, Nau R, Wellmer A, Hakenbeck R, Reinert R, Heinz H, et al. The cell wall-associated serine protease PrtA: a highly conserved virulence factor of Streptococcus pneumoniae. FEMS Microbiol Lett. 2001;205:99-104 pubmed..Immunogenicity of PrtA, limited genetic variation, and the involvement in pneumococcal virulence demonstrated in in vivo experiments might identify PrtA as a promising candidate for a protein based vaccine...
- Löhr K, Möritz C, Contente A, Dobbelstein M. p21/CDKN1A mediates negative regulation of transcription by p53. J Biol Chem. 2003;278:32507-16 pubmed..Taken together, these results strongly suggest that increased expression of p21/CDKN1A is necessary and sufficient for the negative regulation of gene expression by p53. ..
- Schilling S, Niestroj A, Rahfeld J, Hoffmann T, Wermann M, Zunkel K, et al. Identification of human glutaminyl cyclase as a metalloenzyme. Potent inhibition by imidazole derivatives and heterocyclic chelators. J Biol Chem. 2003;278:49773-9 pubmed..The results reveal human QC as a metal-dependent transferase, suggesting that the active site-bound metal is a potential site for interaction with novel, highly potent competitive inhibitors. ..
- Müller F, Bandeiras T, Urich T, Teixeira M, Gomes C, Kletzin A. Coupling of the pathway of sulphur oxidation to dioxygen reduction: characterization of a novel membrane-bound thiosulphate:quinone oxidoreductase. Mol Microbiol. 2004;53:1147-60 pubmed..The larger subunit appeared to be glycosylated and was identical to DoxA, and the smaller was identical to DoxD. Both subunits had been described previously as a part of the terminal quinol:oxygen oxidoreductase complex (cytochrome aa3)...
- Arndt V, Daniel C, Nastainczyk W, Alberti S, Hohfeld J. BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP. Mol Biol Cell. 2005;16:5891-900 pubmed..The presented data therefore establish multiple mechanisms to control the destructive activity of the CHIP ubiquitin ligase in human cells. ..
- K llner T, O Maille P, Gatto N, Boland W, Gershenzon J, Degenhardt J. Two pockets in the active site of maize sesquiterpene synthase TPS4 carry out sequential parts of the reaction scheme resulting in multiple products. Arch Biochem Biophys. 2006;448:83-92 pubmed publisher..Mutations in pocket II primarily inhibited the formation of bicylic compounds, suggesting that secondary cyclizations of the bisabolyl cation are catalyzed in pocket II...
- Lanfranco F, Gromoll J, von Eckardstein S, Herding E, Nieschlag E, Simoni M. Role of sequence variations of the GnRH receptor and G protein-coupled receptor 54 gene in male idiopathic hypogonadotropic hypogonadism. Eur J Endocrinol. 2005;153:845-52 pubmed..Mutations of the GnRHR and of the GPR54 gene are rare in IHH and should be investigated especially in cases with autosomal recessive transmission. Common SNPs of the GnRHR and GPR54 genes do not play any role in IHH. ..
- Mikolajka A, Yan X, Popowicz G, Smialowski P, Nigg E, Holak T. Structure of the N-terminal domain of the FOP (FGFR1OP) protein and implications for its dimerization and centrosomal localization. J Mol Biol. 2006;359:863-75 pubmed..The central part of the dimer contains the LisH domain. We further determined that the FOP LisH domain is part of a longer N-terminal segment that is required, albeit not sufficient, for dimerization and centrosomal localization of FOP. ..
- Rothballer A, Tzvetkov N, Zwickl P. Mutations in p97/VCP induce unfolding activity. FEBS Lett. 2007;581:1197-201 pubmed..Thus, p97 can exert unfoldase activity in vitro, provided that a single tyrosine residue is introduced into the D1 pore and that the N domain is deleted. ..
- Hofmann S, Franke A, Fischer A, Jacobs G, Nothnagel M, Gaede K, et al. Genome-wide association study identifies ANXA11 as a new susceptibility locus for sarcoidosis. Nat Genet. 2008;40:1103-6 pubmed publisher..Annexin A11 has complex and essential functions in several biological pathways, including apoptosis and proliferation. ..
- Haack T, Danhauser K, Haberberger B, Hoser J, Strecker V, Boehm D, et al. Exome sequencing identifies ACAD9 mutations as a cause of complex I deficiency. Nat Genet. 2010;42:1131-4 pubmed publisher..ACAD9 screening of 120 additional complex I-defective index cases led us to identify two additional unrelated cases and a total of five pathogenic ACAD9 alleles. ..
- Piontek A, Rossa J, Protze J, Wolburg H, Hempel C, GÃ¼nzel D, et al. Polar and charged extracellular residues conserved among barrier-forming claudins contribute to tight junction strand formation. Ann N Y Acad Sci. 2017;1397:143-156 pubmed publisher..These residues are all conserved among barrier-forming classic claudins. The results contribute to mechanistic understanding of claudin-based regulation of paracellular permeability. ..
- Schumacher A, Schröter H, Multhaup G, Nordheim A. Murine cyclophilin-S1: a variant peptidyl-prolyl isomerase with a putative signal sequence expressed in differentiating F9 cells. Biochim Biophys Acta. 1991;1129:13-22 pubmed..Specific subcellular localization of PPIases is postulated to contribute to functional specificities of this class of enzymes. ..
- Kuhn K, Bertling W, Emmrich F. Cloning of a functional cDNA for human cytidine deaminase (CDD) and its use as a marker of monocyte/macrophage differentiation. Biochem Biophys Res Commun. 1993;190:1-7 pubmed..The mRNA can be induced in monocytes, the monocytoid cell line U937 and the myeloblastic line HL 60 by the differentiation inducer calcitriol. ..
- Kääb G, Brandl G, Marx A, Wekerle H, Bradl M. The myelin basic protein-specific T cell repertoire in (transgenic) Lewis rat/SCID mouse chimeras: preferential V beta 8.2 T cell receptor usage depends on an intact Lewis thymic microenvironment. Eur J Immunol. 1996;26:981-8 pubmed..They further suggest that the formation of the repertoire requires T cell differentiation in a syngeneic thymic microenvironment. ..
- Massmann S, Schurmann A, Joost H. Cloning of two splicing variants of the novel Ras-related GTPase Rab29 which is predominantly expressed in kidney. Biochim Biophys Acta. 1997;1352:48-55 pubmed..Thus, the C-terminus of Rab29 appears to harbor a structural element which is essential for the nucleotide exchange of the protein. ..
- Hänsler M, Ullmann G, Jakubke H. The application of papain, ficin and clostripain in kinetically controlled peptide synthesis in frozen aqueous solutions. J Pept Sci. 1995;1:283-7 pubmed..Enzyme-catalysed peptide syntheses were carried out under optimized reaction conditions (temperature, amino component concentration and pH before freezing) using the condensation of Bz-Arg-OEt and H-Leu-NH2 as a model reaction. ..
- Gong W, Roth S, Michel K, Gressner A. Isoforms and splice variant of transforming growth factor beta-binding protein in rat hepatic stellate cells. Gastroenterology. 1998;114:352-63 pubmed..The existence of different LTBP isoforms and splice variants in HSCs and myofibroblasts suggests multiple functions of the LTBP family in rat liver, which might not be restricted to the maintenance of TGF-beta latency. ..
- Patzer S, Hantke K. The ZnuABC high-affinity zinc uptake system and its regulator Zur in Escherichia coli. Mol Microbiol. 1998;28:1199-210 pubmed..High-affinity 65Zn2+ transport of the constitutive zur mutant was 10-fold higher than that of the uninduced parental strain. An in vivo titration assay suggested that Zur binds to the bidirectional promoter region of znuA and znuCB...
- Marie Cardine A, Verhagen A, Eckerskorn C, Schraven B. SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55. FEBS Lett. 1998;435:55-60 pubmed..Finally, we demonstrate that, as previously shown for SKAP55, SKAP-HOM interacts with the recently identified polypeptide SLAP-130. ..
- Muller K, Matzanke B, Schunemann V, Trautwein A, Hantke K. FhuF, an iron-regulated protein of Escherichia coli with a new type of [2Fe-2S] center. Eur J Biochem. 1998;258:1001-8 pubmed..The phenotype of fhuF mutants and the structural features of the FhuF protein suggest that FhuF is involved in the reduction of ferric iron in cytoplasmic ferrioxamine B. ..
- Hopfner K, Eichinger A, Engh R, Laue F, Ankenbauer W, Huber R, et al. Crystal structure of a thermostable type B DNA polymerase from Thermococcus gorgonarius. Proc Natl Acad Sci U S A. 1999;96:3600-5 pubmed..This archaeal B DNA polymerase structure provides a starting point for structure-based design of polymerases or ligands with applications in biotechnology and the development of antiviral or anticancer agents...
- Hage T, Sebald W, Reinemer P. Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface. Cell. 1999;97:271-81 pubmed..Novel insights on ligand binding in the cytokine receptor family and a paradigm for receptors of IL-2, IL-7, IL-9, and IL-15, which all utilize gamma c, are provided. ..
- Lisowsky T, Polosa P, Sagliano A, Roberti M, Gadaleta M, Cantatore P. Identification of human GC-box-binding zinc finger protein, a new Krüppel-like zinc finger protein, by the yeast one-hybrid screening with a GC-rich target sequence. FEBS Lett. 1999;453:369-74 pubmed..The new human protein identified in this study was therefore named GC-box-binding zinc finger protein). ..
- Diederichs K, Diez J, Greller G, Muller C, Breed J, Schnell C, et al. Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis. EMBO J. 2000;19:5951-61 pubmed..The structure and its relationship to function are discussed in the light of known mutations from the homologous Escherichia coli and Salmonella typhimurium proteins...
- Borghouts C, Werner A, Elthon T, Osiewacz H. Copper-modulated gene expression and senescence in the filamentous fungus Podospora anserina. Mol Cell Biol. 2001;21:390-9 pubmed..However, it is striking that the permeability of mitochondrial membranes in animal systems changes during apoptosis and that mitochondrial proteins with an important impact on this type of cellular death are released...
- Steinbacher S, Kaiser J, Wungsintaweekul J, Hecht S, Eisenreich W, Gerhardt S, et al. Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids. J Mol Biol. 2002;316:79-88 pubmed publisher..The protein forms homotrimers that tightly bind one zinc ion per subunit at the active site, which helps to position the substrate for direct attack of the 2-phosphate group on the beta-phosphate...
- Jozic D, Bourenkow G, Bartunik H, Scholze H, Dive V, Henrich B, et al. Crystal structure of the dinuclear zinc aminopeptidase PepV from Lactobacillus delbrueckii unravels its preference for dipeptides. Structure. 2002;10:1097-106 pubmed..The cocrystallized inhibitor illustrates the two roles of the two catalytic zinc ions, namely stabilization of the tetrahedral intermediate and activation of the catalytic water molecule...
- Pappalardo L, Janausch I, Vijayan V, Zientz E, Junker J, Peti W, et al. The NMR structure of the sensory domain of the membranous two-component fumarate sensor (histidine protein kinase) DcuS of Escherichia coli. J Biol Chem. 2003;278:39185-8 pubmed..The structure constitutes the first periplasmic domain of a two component sensory system and is distinctly different from the aspartate sensory domain of the Tar chemotaxis sensor. ..
- Wilson R, Battersby A, Csiszar A, Vogelsang E, Leptin M. A functional domain of Dof that is required for fibroblast growth factor signaling. Mol Cell Biol. 2004;24:2263-76 pubmed..In addition, we demonstrate that Dof is phosphorylated in the presence of an activated FGF receptor and that tyrosine residues could contribute to the function of the molecule. ..
- Bräuer A, Nitsch R, Savaskan N. Identification of macrophage/microglia activation factor (MAF) associated with late endosomes/lysosomes in microglial cells. FEBS Lett. 2004;563:41-8 pubmed..In conclusion, these results imply that MAF is involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion. ..
- Sell S, Hehl R. Functional dissection of a small anaerobically induced bZIP transcription factor from tomato. Eur J Biochem. 2004;271:4534-44 pubmed publisher..This correlates with the anaerobic down regulation of the 35S promoter in tomato and tobacco. These results may suggest that small bZIP proteins are involved in the negative regulation of gene expression under anaerobic conditions...
- Munch J, Schindler M, Wildum S, Rücker E, Bailer N, Knoop V, et al. Primary sooty mangabey simian immunodeficiency virus and human immunodeficiency virus type 2 nef alleles modulate cell surface expression of various human receptors and enhance viral infectivity and replication. J Virol. 2005;79:10547-60 pubmed..These differences in Nef function might contribute to the relatively low levels of immune activation observed in HIV-2-infected human individuals...
- Lee C, Illarionov B, Woo Y, Kemter K, Kim R, Eberhardt S, et al. Ligand binding properties of the N-terminal domain of riboflavin synthase from Escherichia coli. J Biochem Mol Biol. 2007;40:239-46 pubmed
- Daub H, Olsen J, Bairlein M, Gnad F, Oppermann F, Körner R, et al. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008;31:438-48 pubmed publisher..These results provide a vastly extended knowledge base for functional studies on kinases and their regulation through site-specific phosphorylation. ..
- Thoms S, Debelyy M, Connerth M, Daum G, Erdmann R. The putative Saccharomyces cerevisiae hydrolase Ldh1p is localized to lipid droplets. Eukaryot Cell. 2011;10:770-5 pubmed publisher..Ldh1p is not required for the function and biogenesis of peroxisomes, and targeting of Ldh1p to lipid droplets occurs independently of the PTS1 receptor Pex5p. ..
- Wohlrab S, Muller S, Schmidt A, Neubauer S, Kessler H, Leal Egaña A, et al. Cell adhesion and proliferation on RGD-modified recombinant spider silk proteins. Biomaterials. 2012;33:6650-9 pubmed publisher..Interestingly, the genetically created hybrid protein (with a linear RGD sequence) showed similar or slightly better cell adhesion properties as the silk protein chemically modified with the cyclic RGD peptide. ..
- Heuveling J, Frochaux V, Ziomkowska J, Wawrzinek R, Wessig P, Herrmann A, et al. Conformational changes of the bacterial type I ATP-binding cassette importer HisQMP2 at distinct steps of the catalytic cycle. Biochim Biophys Acta. 2014;1838:106-16 pubmed publisher..Together, our data suggest similar conformational changes during the transport cycle as described for the maltose ABC transporter of Escherichia coli, despite distinct structural differences between both systems. ..
- Kohli P, Bartram M, Habbig S, Pahmeyer C, Lamkemeyer T, Benzing T, et al. Label-free quantitative proteomic analysis of the YAP/TAZ interactome. Am J Physiol Cell Physiol. 2014;306:C805-18 pubmed publisher..Taken together, the stringent approach presented here could help to significantly sharpen the understanding of protein-protein networks. ..
- Neher R, Bedford T, Daniels R, Russell C, Shraiman B. Prediction, dynamics, and visualization of antigenic phenotypes of seasonal influenza viruses. Proc Natl Acad Sci U S A. 2016;113:E1701-9 pubmed publisher..To make timely model output readily available, we developed a web browser-based application that visualizes antigenic data on a continuously updated phylogeny. ..
- Spitzer M, Lorkowski S, Cullen P, Sczyrba A, Fuellen G. IsoSVM--distinguishing isoforms and paralogs on the protein level. BMC Bioinformatics. 2006;7:110 pubmed..It can be used to analyze, for example, EST data and database search results. Our software is freely available on the Web, under the name IsoSVM. ..
- Stoller G, Tradler T, Rücknagel K, Rahfeld J U -, Fischer G. An 11.8 kDa proteolytic fragment of the E. coli trigger factor represents the domain carrying the peptidyl-prolyl cis/trans isomerase activity. FEBS Lett. 1996;384:117-22 pubmed..3 microM(-1) s(-1) could be demonstrated when using Suc-Ala-Phe-Pro-Phe-NH-Np as a substrate. Moreover, as was observed for the complete, authentic TF the PPIase activity of the fragment was not inhibited by the peptidomacrolide FK506. ..
- Harms U, Thauer R. Methylcobalamin: coenzyme M methyltransferase isoenzymes MtaA and MtbA from Methanosarcina barkeri. Cloning, sequencing and differential transcription of the encoding genes, and functional overexpression of the mtaA gene in Escherichia coli. Eur J Biochem. 1996;235:653-9 pubmed..coli. 25% of the E. coli protein was found to be active methyltransferase which could be purified in two steps to apparent homogeneity with a 70% yield...
- Storck J, Zimmermann E. Regulation of the thrombin receptor response in human endothelial cells. Thromb Res. 1996;81:121-31 pubmed..Desensitisation is similar in thrombin and TRAP stimulated cells. We assumed a transport mechanism for intracellular stored vesicles for receptor resensitisation; a co-localisation with vWf in the Weibel-Palade bodies is improbable...
- Faix J, Dittrich W. DGAP1, a homologue of rasGTPase activating proteins that controls growth, cytokinesis, and development in Dictyostelium discoideum. FEBS Lett. 1996;394:251-7 pubmed..discoideum, ras or a related small GTP-binding protein is involved in regulating growth based on the phagocytosis of bacteria, and in coupling activities of the cell cortex to the organization of spindle and asters in mitotic cells. ..
- Gomis Rüth F, Gohlke U, Betz M, Knauper V, Murphy G, Lopez Otin C, et al. The helping hand of collagenase-3 (MMP-13): 2.7 A crystal structure of its C-terminal haemopexin-like domain. J Mol Biol. 1996;264:556-66 pubmed
- Knackmuss S, Bautz E, Petersen G. Identification of the gene coding for the largest subunit of RNA polymerase I (A) of Drosophila melanogaster. Mol Gen Genet. 1997;253:529-34 pubmed
- Hofmann M, Fieber C, Assmann V, Gottlicher M, Sleeman J, Plug R, et al. Identification of IHABP, a 95 kDa intracellular hyaluronate binding protein. J Cell Sci. 1998;111 ( Pt 12):1673-84 pubmed..Clearly, the sequence we have identified encodes a protein with properties substantially different to the RHAMM protein. We tentatively name the protein intracellular hyaluronic acid binding protein, IHABP. ..
- Killmann H, Herrmann C, Wolff H, Braun V. Identification of a new site for ferrichrome transport by comparison of the FhuA proteins of Escherichia coli, Salmonella paratyphi B, Salmonella typhimurium, and Pantoea agglomerans. J Bacteriol. 1998;180:3845-52 pubmed
- Derst C, Wischmeyer E, Preisig M ller R, Spauschus A, Konrad M, Hensen P, et al. A hyperprostaglandin E syndrome mutation in Kir1.1 (renal outer medullary potassium) channels reveals a crucial residue for channel function in Kir1.3 channels. J Biol Chem. 1998;273:23884-91 pubmed..3 channels the extracellular positively charged lysine is of crucial functional importance. The HPS phenotype in man can be explained by the lower expression of functional channels by the Kir1. 1a[N124K] mutant...
- Kohler C, Merkle T, Neuhaus G. Characterisation of a novel gene family of putative cyclic nucleotide- and calmodulin-regulated ion channels in Arabidopsis thaliana. Plant J. 1999;18:97-104 pubmed..Therefore, we propose that the identified genes constitute a family of plant cyclic nucleotide- and CaM-regulated ion channels. ..
- Tudzynski B. Biosynthesis of gibberellins in Gibberella fujikuroi: biomolecular aspects. Appl Microbiol Biotechnol. 1999;52:298-310 pubmed..This review gives a short overview of the well-known physiological and biochemical studies and concentrates mainly on the new molecular genetic data from GA research, including new information on the regulation of GA biosynthesis...
- Heermann R, Altendorf K, Jung K. The hydrophilic N-terminal domain complements the membrane-anchored C-terminal domain of the sensor kinase KdpD of Escherichia coli. J Biol Chem. 2000;275:17080-5 pubmed..These results highlight the importance of the N-terminal domain for the function of KdpD and provide evidence for an interaction of this domain and the transmitter domain of the sensor kinase. ..
- Konig J, Cui Y, Nies A, Keppler D. Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide. J Biol Chem. 2000;275:23161-8 pubmed..Thus, human OATP8 is a new uptake transporter in the basolateral hepatocyte membrane with an overlapping but distinct substrate specificity as compared with OATP2, which is localized to the same membrane domain. ..
- Tillmann H, Bernhard D, Eschrich K. Fructose-1,6-bisphosphatase genes in animals. Gene. 2002;291:57-66 pubmed..The question of what might be the advantage of having more than one gene coding for FbPase per haploid genome is discussed...
- Scherer M, Wei H, Liese R, Fischer R. Aspergillus nidulans catalase-peroxidase gene (cpeA) is transcriptionally induced during sexual development through the transcription factor StuA. Eukaryot Cell. 2002;1:725-35 pubmed..The Hülle cell-specific expression was dependent on the developmental regulator StuA, suggesting an activating function of this helix-loop-helix transcription factor. ..
- Selenko P, Gregorovic G, Sprangers R, Stier G, Rhani Z, Kramer A, et al. Structural basis for the molecular recognition between human splicing factors U2AF65 and SF1/mBBP. Mol Cell. 2003;11:965-76 pubmed..This molecular recognition establishes a paradigm for protein binding by a subfamily of noncanonical RRMs. ..
- Tobaben S, Varoqueaux F, Brose N, Stahl B, Meyer G. A brain-specific isoform of small glutamine-rich tetratricopeptide repeat-containing protein binds to Hsc70 and the cysteine string protein. J Biol Chem. 2003;278:38376-83 pubmed..The modular structure of SGTs allows them to recruit client proteins to Hsc70 and to direct the resulting complex toward downstream proteins that take over the respective client proteins. ..
- Steller S, Sokoll A, Wilde C, Bernhard F, Franke P, Vater J. Initiation of surfactin biosynthesis and the role of the SrfD-thioesterase protein. Biochemistry. 2004;43:11331-43 pubmed..Menkhaus et al. (1993) J. Biol. Chem. 268, 7678-7684], thus enhancing surfactin formation. ..
- Marg B, Schweimer K, Sticht H, Oesterhelt D. A two-alpha-helix extra domain mediates the halophilic character of a plant-type ferredoxin from halophilic archaea. Biochemistry. 2005;44:29-39 pubmed publisher..salinarum, and the ability to efficiently reconstitute the iron-sulfur cluster only at high salt concentrations...
- Kutzleb C, Busmann A, Wendland M, Maronde E. Discovery of novel regulatory peptides by reverse pharmacology: spotlight on chemerin and the RF-amide peptides metastin and QRFP. Curr Protein Pept Sci. 2005;6:265-78 pubmed
- Nitz I, Döring F, Schrezenmeir J, Burwinkel B. Identification of new acyl-CoA binding protein transcripts in human and mouse. Int J Biochem Cell Biol. 2005;37:2395-405 pubmed..Given the fact that the new variant is highly expressed in adipose tissue and a PPARgamma target, it might be relevant for diseases like diabetes and obesity. ..
- Schwake M, Athanasiadu D, Beimgraben C, Blanz J, Beck C, Jentsch T, et al. Structural determinants of M-type KCNQ (Kv7) K+ channel assembly. J Neurosci. 2006;26:3757-66 pubmed
- Fedorov R, Witte G, Urbanke C, Manstein D, Curth U. 3D structure of Thermus aquaticus single-stranded DNA-binding protein gives insight into the functioning of SSB proteins. Nucleic Acids Res. 2006;34:6708-17 pubmed..A model for binding this region to the chi subunit of DNA polymerase III is proposed. It explains at a molecular level the reason for the ssb113 phenotype observed in Escherichia coli. ..
- Mann K. The chicken egg white proteome. Proteomics. 2007;7:3558-68 pubmed..The list of egg white proteins provided is by far the most comprehensive at present and is intended to serve as a starting point for the isolation and functional characterization of interesting new proteins. ..
- Böhmer C, Böhmer M, Bölker M, Sandrock B. Cdc42 and the Ste20-like kinase Don3 act independently in triggering cytokinesis in Ustilago maydis. J Cell Sci. 2008;121:143-8 pubmed..We propose, that Don3 is involved in establishing a landmark, at which the Cdc42-dependent actomyosin ring formation will occur. ..
- Kaschani F, Gu C, Niessen S, Hoover H, Cravatt B, van der Hoorn R. Diversity of serine hydrolase activities of unchallenged and botrytis-infected Arabidopsis thaliana. Mol Cell Proteomics. 2009;8:1082-93 pubmed publisher..Besides the down-regulation of several Arabidopsis Ser hydrolase activities during Botrytis infection, we detected the activities of Botrytis-derived cutinases and lipases, which are thought to contribute to pathogenicity. ..
- Weidlich D, Wiesemann N, Heuveling J, Wardelmann K, Landmesser H, Sani K, et al. Residues of a proposed gate region in type I ATP-binding cassette import systems are crucial for function as revealed by mutational analysis. Biochim Biophys Acta. 2013;1828:2164-72 pubmed publisher..Our study provides the first experimental evidence in favor of a crucial role of residues from the proposed gate region in type I ABC importer function. ..
- Upadhyaya S, Ayelet G, Paul G, King D, Paton D, Mahapatra M. Genetic basis of antigenic variation in foot-and-mouth disease serotype A viruses from the Middle East. Vaccine. 2014;32:631-8 pubmed publisher..Comparisons of capsid sequences identified substitutions in neutralising antigenic sites (1, 2 and 4), which either individually or together underpin these observed antigenic phenotypes. ..
- Schmidt M, Kroger B, Jacob E, Seulberger H, Subkowski T, Otter R, et al. Molecular characterization of human and bovine endothelin converting enzyme (ECE-1). FEBS Lett. 1994;356:238-43 pubmed..The catalytic activity of the recombinant enzyme is the same as that determined for the natural enzyme. The data suggest that the characterized enzyme represents the functional human endothelin converting enzyme ECE-1. ..
- Richardson J, Kroger B, Hoeffken W, Sadler J, Pereira P, Huber R, et al. Crystal structure of the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor. EMBO J. 2000;19:5650-60 pubmed..This specific anticoagulant ability of haemadin makes it an ideal candidate for an antithrombotic agent, as well as a starting point for the design of novel antithrombotics. ..
- Micka B, Marahiel M. The DNA-binding protein HBsu is essential for normal growth and development in Bacillus subtilis. Biochimie. 1992;74:641-50 pubmed..A comparative sequence analysis of HBsu with 18 homologous histonelike proteins of diverse origin demonstrated their high conservation throughout evolution. ..
- Schurmann A, Brauers A, Massmann S, Becker W, Joost H. Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases. J Biol Chem. 1995;270:28982-8 pubmed..It is suggested that RagA and RagB are the mammalian homologues of Gtr1 and that they represent a novel subfamily of Ras-homologous GTP binding proteins. ..
- Schurig H, Rutkat K, Rachel R, Jaenicke R. Octameric enolase from the hyperthermophilic bacterium Thermotoga maritima: purification, characterization, and image processing. Protein Sci. 1995;4:228-36 pubmed publisher..Fluoride and phosphate cause competitive inhibition with a Ki of 0.14 mM. The enzyme shows high intrinsic thermal stability, with a thermal transition at 90 and 94 degrees C in the absence and in the presence of Mg2+...
- Schrautemeier B, Neveling U, Schmitz S. Distinct and differently regulated Mo-dependent nitrogen-fixing systems evolved for heterocysts and vegetative cells of Anabaena variabilis ATCC 29413: characterization of the fdxH1/2 gene regions as part of the nif1/2 gene clusters. Mol Microbiol. 1995;18:357-69 pubmed..Accordingly, its expression has become an obligate late event in the developmental programme of heterocyst differentiation, irrespective of aerobic or anaerobic growth conditions. ..
- von Nickisch Rosenegk E, Krieger J, Kubick S, Laage R, Strobel J, Strotmann J, et al. Cloning of biogenic amine receptors from moths (Bombyx mori and Heliothis virescens). Insect Biochem Mol Biol. 1996;26:817-27 pubmed..As revealed by in situ hybridization, this receptor type is expressed in the central nervous system and antennae of moth. ..
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