Experts and Doctors on amino acid sequence in Belgium

Summary

Locale: Belgium
Topic: amino acid sequence

Top Publications

  1. Belles Boix E, Babiychuk E, Montagu M, Inze D, Kushnir S. CEF, a sec24 homologue of Arabidopsis thaliana, enhances the survival of yeast under oxidative stress conditions. J Exp Bot. 2000;51:1761-2 pubmed
    ..CEF is homologous to animal and yeast Sec24 proteins. These data suggest that CEF plays a protective role through protein transport during growth under pro-oxidant conditions. ..
  2. Gielens C, Idakieva K, De Maeyer M, Van den Bergh V, Siddiqui N, Compernolle F. Conformational stabilization at the active site of molluskan (Rapana thomasiana) hemocyanin by a cysteine-histidine thioether bridge A study by mass spectrometry and molecular modeling. Peptides. 2007;28:790-7 pubmed
    ..It is suggested that the role of the bridge is to fix the histidine in an orientation that is optimal for coordination of the Cu(A) atom...
  3. St landre M, Bosseloir Y, De Bruyn J, Maes P, Content J. Cloning and sequence analysis of the gene encoding an NADP-dependent alcohol dehydrogenase in Mycobacterium bovis BCG. Gene. 1992;121:79-86 pubmed
    ..Of the 22 strictly conserved residues in this group, 19 are also conserved in M. bovis BCG ADH (BCGADH)...
  4. Van Ranst M, Norga K, Masure S, Proost P, Vandekerckhove F, Auwerx J, et al. The cytokine-protease connection: identification of a 96-kD THP-1 gelatinase and regulation by interleukin-1 and cytokine inducers. Cytokine. 1991;3:231-9 pubmed
    ..The active enzyme produced by THP-1 cells consistently showed, however, a molecular mass different from that of normal granulocyte-, monocyte-, and tumor cell-derived gelatinases.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  5. De Jaegere S, Wuytack F, Eggermont J, Verboomen H, Casteels R. Molecular cloning and sequencing of the plasma-membrane Ca2+ pump of pig smooth muscle. Biochem J. 1990;271:655-60 pubmed
    ..It is suggested that these two polypeptides could result from a post-translational modification of one single enzyme. ..
  6. Tebabi P, Halleux S, Pays E. Nucleotide sequence of a full-length cDNA coding for the ribosomal L44 protein of Trypanosoma brucei. Nucleic Acids Res. 1990;18:2809 pubmed
  7. Libert F, Lefort A, Gerard C, Parmentier M, Perret J, Ludgate M, et al. Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies. Biochem Biophys Res Commun. 1989;165:1250-5 pubmed
    ..TSH binding was completely displaced by immunoglobulin preparations from patients with idiopathic myxoedema. ..
  8. Decroly E, VandenBranden M, Ruysschaert J, Cogniaux J, Jacob G, Howard S, et al. The convertases furin and PC1 can both cleave the human immunodeficiency virus (HIV)-1 envelope glycoprotein gp160 into gp120 (HIV-1 SU) and gp41 (HIV-I TM). J Biol Chem. 1994;269:12240-7 pubmed
    ..Transition state analog peptides were designed and tested in vitro for their ability to inhibit the PC1- or furin-mediated gp160 cleavage. The best inhibitor was decanoyl-Arg-Lys-Arg-Arg-psi [CH2NH]-Phe-Leu-Gly-Phe-NH2. ..
  9. Gaugler B, Brouwenstijn N, Vantomme V, Szikora J, Van der Spek C, Patard J, et al. A new gene coding for an antigen recognized by autologous cytolytic T lymphocytes on a human renal carcinoma. Immunogenetics. 1996;44:323-30 pubmed
    ..This represents the first identification of an antigen recognized by autologous CTL on a renal tumor. ..

More Information

Publications352 found, 100 shown here

  1. Schollen E, Pardon E, Heykants L, Renard J, Doggett N, Callen D, et al. Comparative analysis of the phosphomannomutase genes PMM1, PMM2 and PMM2psi: the sequence variation in the processed pseudogene is a reflection of the mutations found in the functional gene. Hum Mol Genet. 1998;7:157-64 pubmed
    ..Thus, mutations that occur at a slow rate in the active gene in the population have also accumulated in the pseudogene. ..
  2. Messens J, Hayburn G, Desmyter A, Laus G, Wyns L. The essential catalytic redox couple in arsenate reductase from Staphylococcus aureus. Biochemistry. 1999;38:16857-65 pubmed
    ..From the peptide-mass profiles, cysteines 82 and 89 were identified as the redox couple of ArsC necessary to reduce arsenate to arsenite...
  3. Schurmans S, Carrio R, Behrends J, Pouillon V, Merino J, Clement S. The mouse SHIP2 (Inppl1) gene: complementary DNA, genomic structure, promoter analysis, and gene expression in the embryo and adult mouse. Genomics. 1999;62:260-71 pubmed
    ..The subtle differences in the protein structure of SHIP2 and SHIP1 as well as their different patterns of expression are discussed. ..
  4. Taelman V, Opdecamp K, Avalosse B, Ryan K, Bellefroid E. Xath2, a bHLH gene expressed during a late transition stage of neurogenesis in the forebrain of Xenopus embryos. Mech Dev. 2001;101:199-202 pubmed
    ..Within the neuroepithelium of the dorsal telencephalon, Xath2 expression is detected in postmitotic cells located more laterally than those expressing several other related bHLH neuronal regulators. ..
  5. Dhaese P, De Greve H, Gielen J, Seurinck L, Van Montagu M, Schell J. Identification of sequences involved in the polyadenylation of higher plant nuclear transcripts using Agrobacterium T-DNA genes as models. EMBO J. 1983;2:419-26 pubmed
    ..Three other sites are located within the adjacent plant DNA, giving rise to hybrid T-DNA/plant DNA transcripts. The two most distal sites are probably dependent on a motif AATAAATAAA, found 29 bp away from the T-DNA/plant DNA junction...
  6. Donaton M, Holsbeeks I, Lagatie O, Van Zeebroeck G, Crauwels M, Winderickx J, et al. The Gap1 general amino acid permease acts as an amino acid sensor for activation of protein kinase A targets in the yeast Saccharomyces cerevisiae. Mol Microbiol. 2003;50:911-29 pubmed
  7. Verleyen P, Baggerman G, Wiehart U, Schoeters E, Van Lommel A, De Loof A, et al. Expression of a novel neuropeptide, NVGTLARDFQLPIPNamide, in the larval and adult brain of Drosophila melanogaster. J Neurochem. 2004;88:311-9 pubmed
    ..Based on this distribution pattern, IPNamide might be involved in phototransduction, in processing sensory stimuli, as well as in controlling the activity of the oesophagus. ..
  8. Lorquet F, Goffin P, Muscariello L, Baudry J, Ladero V, Sacco M, et al. Characterization and functional analysis of the poxB gene, which encodes pyruvate oxidase in Lactobacillus plantarum. J Bacteriol. 2004;186:3749-59 pubmed
    ..In agreement with the latter observation, the level of residual pyruvate oxidase activity with maltose limitation (0.2% maltose) was less than 10% of the wild-type level of activity. ..
  9. Bogaerts S, Vanlandschoot A, van Hengel J, van Roy F. Nuclear translocation of alphaN-catenin by the novel zinc finger transcriptional repressor ZASC1. Exp Cell Res. 2005;311:1-13 pubmed
    ..The interaction and nuclear cotranslocation of a neural alpha-catenin with a putative proto-oncogene product as reported here provides novel insights into the signaling functions of alpha-catenins. ..
  10. Wakula P, Beullens M, Van Eynde A, Ceulemans H, Stalmans W, Bollen M. The translation initiation factor eIF2beta is an interactor of protein phosphatase-1. Biochem J. 2006;400:377-83 pubmed
    ..The overexpression of wild-type eIF2beta or eIF2beta with a mutated RVxF-motif did not differentially affect the rate of translation, indicating that the binding of PP1 is not rate-limiting for translation under basal conditions. ..
  11. Sauvage E, Duez C, Herman R, Kerff F, Petrella S, Anderson J, et al. Crystal structure of the Bacillus subtilis penicillin-binding protein 4a, and its complex with a peptidoglycan mimetic peptide. J Mol Biol. 2007;371:528-39 pubmed publisher
    ..The adduct also reveals a binding pocket specific to the diaminopimelic acid, the third residue of the peptidoglycan stem pentapeptide of B. subtilis. This pocket is specific for this class of PBPs...
  12. Kwasigroch J, Wintjens R, Gilis D, Rooman M. SODa: an Mn/Fe superoxide dismutase prediction and design server. BMC Bioinformatics. 2008;9:257 pubmed publisher
    ..SODa is shown to outperform and to be more discriminative than traditional techniques based on pairwise sequence alignments. Moreover, the fact that it proposes selected mutations makes it a valuable tool for rational protein design. ..
  13. Verleyen P, Huybrechts J, Schoofs L. SIFamide illustrates the rapid evolution in Arthropod neuropeptide research. Gen Comp Endocrinol. 2009;162:27-35 pubmed publisher
    ..The immunoreactive patterns in the brain refer to a neuromodulatory role in combining visual, tactile and olfactory input. Eventually, targeted cell ablation and RNAi revealed that SIFamide modulates sexual behaviour in fruit flies. ..
  14. Vergauwen B, Van der Meeren R, Dansercoer A, Savvides S. Delineation of the Pasteurellaceae-specific GbpA-family of glutathione-binding proteins. BMC Biochem. 2011;12:59 pubmed publisher
    ..Our studies strongly implicate GbpA family SBPs in the priming step of ABC-transporter-mediated translocation of useful forms of glutathione across the inner membrane, and rule out a general role for GbpA proteins in heme acquisition. ..
  15. Besserer A, Burnotte E, Bienert G, Chevalier A, Errachid A, Grefen C, et al. Selective regulation of maize plasma membrane aquaporin trafficking and activity by the SNARE SYP121. Plant Cell. 2012;24:3463-81 pubmed
    ..Together with previous data demonstrating the role of SYP121 in regulating K(+) channel trafficking and activity, these results suggest that SYP121 SNARE contributes to the regulation of the cell osmotic homeostasis. ..
  16. Rolain T, Bernard E, Beaussart A, Degand H, Courtin P, Egge Jacobsen W, et al. O-glycosylation as a novel control mechanism of peptidoglycan hydrolase activity. J Biol Chem. 2013;288:22233-47 pubmed publisher
    ..To the best of our knowledge, this is the first time that O-glycosylation is shown to control the activity of a bacterial enzyme. ..
  17. Christiaens H, Leer R, Pouwels P, Verstraete W. Cloning and expression of a conjugated bile acid hydrolase gene from Lactobacillus plantarum by using a direct plate assay. Appl Environ Microbiol. 1992;58:3792-8 pubmed
    ..7 and 5.5. Optimum temperature ranged from 30 to 45 degrees C. Southern blot analysis indicated that the cloned gene has similarity with genomic DNA of bile acid hydrolase-active Lactobacillus spp. of intestinal origin...
  18. Van Damme J, Rampart M, Conings R, Decock B, Van Osselaer N, Willems J, et al. The neutrophil-activating proteins interleukin 8 and beta-thromboglobulin: in vitro and in vivo comparison of NH2-terminally processed forms. Eur J Immunol. 1990;20:2113-8 pubmed
    ..It can be concluded that the platelet factor beta TG, structurally related to the monokine IL8, can also play a role in neutrophil activation during inflammatory reactions. ..
  19. Van Damme J, Van Beeumen J, Decock B, Van Snick J, De Ley M, Billiau A. Separation and comparison of two monokines with lymphocyte-activating factor activity: IL-1 beta and hybridoma growth factor (HGF). Identification of leukocyte-derived HGF as IL-6. J Immunol. 1988;140:1534-41 pubmed
    ..Both IL-1 and IL-6 possessed lymphocyte-activating factor activity, which could be neutralized only by an anti-serum against the corresponding cytokine. ..
  20. Hemerly A, Engler J, Bergounioux C, Van Montagu M, Engler G, Inze D, et al. Dominant negative mutants of the Cdc2 kinase uncouple cell division from iterative plant development. EMBO J. 1995;14:3925-36 pubmed
    ..Morphogenesis, histogenesis and developmental timing were unaffected. The results indicate that, in plants, the developmental controls defining shape can act independently from cell division rates. ..
  21. Vereecke D, Villarroel R, Van Montagu M, Desomer J. Cloning and sequence analysis of the gene encoding isocitrate lyase from Rhodococcus fascians. Gene. 1994;145:109-14 pubmed
    ..Comparison of the prokaryotic and eukaryotic Icl confirms the earlier proposal of Matsuoka and McFadden [J. Bacteriol. 143 (1988) 4528-4536] that the enzyme has enlarged during evolution. ..
  22. Samyn B, Van Craenenbroeck K, De Smet L, Vandenberghe I, Pettigrew G, Van Beeumen J. A reinvestigation of the covalent structure of Pseudomonas aeruginosa cytochrome c peroxidase. FEBS Lett. 1995;377:145-9 pubmed
    ..1995) FEBS Lett. 365, 152-154]. Based on this sequence, we propose a new model for the binding of the peroxide and the cytochrome electron donor to CCP which is in essence the reverse of the one proposed by Ellfolk et al. ..
  23. De Plaen E, Naerhuyzen B, de Smet C, Szikora J, Boon T. Alternative promoters of gene MAGE4a. Genomics. 1997;40:305-13 pubmed
    ..5 stimulated a high level of transcription in a melanoma cell line that does not express MAGE-4. This suggests that the tumor-specific expression of MAGE genes is not determined by the presence of specific transcription factors. ..
  24. Lurquin C, de Smet C, Brasseur F, Muscatelli F, Martelange V, De Plaen E, et al. Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins. Genomics. 1997;46:397-408 pubmed
    ..The transcription of MAGE-B1 and MAGE-B2 can be induced by 5-aza-2'-deoxycytidine, suggesting that the activation of these genes in tumors results from a demethylation process. ..
  25. el Alami M, Feller A, Pierard A, Dubois E. Characterisation of a tripartite nuclear localisation sequence in the regulatory protein Lys14 of Saccharomyces cerevisiae. Curr Genet. 2000;38:78-86 pubmed
    ..Simultaneous mutations in the three basic domains are required to completely abolish the entry into the nucleus and to impair the Lys14 function. ..
  26. Jagiello I, Van Eynde A, Vulsteke V, Beullens M, Boudrez A, Keppens S, et al. Nuclear and subnuclear targeting sequences of the protein phosphatase-1 regulator NIPP1. J Cell Sci. 2000;113 Pt 21:3761-8 pubmed
    ..This domain is also required for the nuclear retention of NIPP1 when active transport is blocked. Our data imply that the nuclear and subnuclear targeting of NIPP1 are controlled independently. ..
  27. Detheux M, Ständker L, Vakili J, Munch J, Forssmann U, Adermann K, et al. Natural proteolytic processing of hemofiltrate CC chemokine 1 generates a potent CC chemokine receptor (CCR)1 and CCR5 agonist with anti-HIV properties. J Exp Med. 2000;192:1501-8 pubmed
    ..It might also affect HIV-1 replication in infected individuals and play an important role in AIDS pathogenesis. ..
  28. Simonet G, Claeys I, Broeck J. Structural and functional properties of a novel serine protease inhibiting peptide family in arthropods. Comp Biochem Physiol B Biochem Mol Biol. 2002;132:247-55 pubmed
    ..Northern blot analysis indicated that the genes encoding the SGPI precursors are differentially expressed in a time-, stage- and hormone-dependent manner. ..
  29. Cools J, Wlodarska I, Somers R, Mentens N, Pedeutour F, Maes B, et al. Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor. Genes Chromosomes Cancer. 2002;34:354-62 pubmed
    ..These results confirm the recurrent involvement of ALK in IMT and further demonstrate the diversity of ALK fusion partners, with the ability to homodimerize as a common characteristic. ..
  30. Rongvaux A, Shea R, Mulks M, Gigot D, Urbain J, Leo O, et al. Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis. Eur J Immunol. 2002;32:3225-34 pubmed
    ..The present findings are in keeping with the ubiquitous nature of this protein, and indicate that NAD biosynthesis may play an important role in lymphocyte activation. ..
  31. Vandenbussche M, Theissen G, Van de Peer Y, Gerats T. Structural diversification and neo-functionalization during floral MADS-box gene evolution by C-terminal frameshift mutations. Nucleic Acids Res. 2003;31:4401-9 pubmed
    ..3' terminal frameshift mutations might provide an important but so far unrecognized mechanism to generate novel functional C-terminal motifs instrumental to the functional diversification of transcription factor families. ..
  32. Vantus T, Vertommen D, Saelens X, Rykx A, De Kimpe L, Vancauwenbergh S, et al. Doxorubicin-induced activation of protein kinase D1 through caspase-mediated proteolytic cleavage: identification of two cleavage sites by microsequencing. Cell Signal. 2004;16:703-9 pubmed
    ..Our results indicate that doxorubicin-mediated apoptosis induces activation of PKD1 through a novel mechanism involving the caspase-mediated proteolysis. ..
  33. Laurent T, Mertens P, Dierick J, Letesson J, Lambert C, De Bolle X. Functional, molecular and structural characterisation of five anti-Brucella LPS mAb. Mol Immunol. 2004;40:1237-47 pubmed
    ..The analysis of their 3D structure gives new hypothesis of the epitopes recognised. ..
  34. Peelman F, Iserentant H, de Smet A, Vandekerckhove J, Zabeau L, Tavernier J. Mapping of binding site III in the leptin receptor and modeling of a hexameric leptin.leptin receptor complex. J Biol Chem. 2006;281:15496-504 pubmed
    ..The 2:4 hexameric leptin.LR complex offers a rational explanation for mutagenesis studies and residue conservation. ..
  35. Deprez L, Weckhuysen S, Peeters K, Deconinck T, Claeys K, Claes L, et al. Epilepsy as part of the phenotype associated with ATP1A2 mutations. Epilepsia. 2008;49:500-8 pubmed
    ..It may be worthwhile to screen patients with a combination of epilepsy and migraine and a positive family history of either migraine or epilepsy for mutations in the ATP1A2 gene. ..
  36. Roovers M, Oudjama Y, Kaminska K, Purta E, Caillet J, Droogmans L, et al. Sequence-structure-function analysis of the bifunctional enzyme MnmC that catalyses the last two steps in the biosynthesis of hypermodified nucleoside mnm5s2U in tRNA. Proteins. 2008;71:2076-85 pubmed publisher
    ..Interestingly, the N-terminal domain is capable of independent folding, while the isolated C-terminal domain is incapable of folding on its own, a situation similar to the one reported recently for the rRNA modification enzyme RsmC. ..
  37. Gauthier C, Clerisse F, Dommes J, Jaspar Versali M. Characterization and cloning of chitin deacetylases from Rhizopus circinans. Protein Expr Purif. 2008;59:127-37 pubmed publisher
    ..5-6 at 37 degrees C. It was strongly inhibited by Cu(2+). The isolation of several chitin deacetylase cDNAs from the same microorganism is discussed. ..
  38. Bauvois C, Jacquamet L, Huston A, Borel F, Feller G, Ferrer J. Crystal structure of the cold-active aminopeptidase from Colwellia psychrerythraea, a close structural homologue of the human bifunctional leukotriene A4 hydrolase. J Biol Chem. 2008;283:23315-25 pubmed publisher
    ..This observation supports the hypothesis that this region of the LTA4H active site has evolved in order to fit the lipidic substrate. ..
  39. Willems P, Magri V, Cretnik M, Fasano M, Jakubowska A, Levanat S, et al. Characterization of the c.190T>C missense mutation in BRCA1 codon 64 (Cys64Arg). Int J Oncol. 2009;34:1005-15 pubmed
    ..190T>C mutation, revealed a genetic profile consistent with the hypothetic role of both polymorphisms. ..
  40. Cerf E, Sarroukh R, Tamamizu Kato S, Breydo L, Derclaye S, Dufrêne Y, et al. Antiparallel beta-sheet: a signature structure of the oligomeric amyloid beta-peptide. Biochem J. 2009;421:415-23 pubmed publisher
    ..We discuss our results in terms of a possible organization of the antiparallel beta-sheets in Abeta oligomers, which may be related to reported effects of these highly toxic species in the amyloid pathogenesis associated with AD. ..
  41. D Aloia M, Tamseddak K, Bonhomme D, Bonhomme F, Bernier G, Périlleux C. Gene activation cascade triggered by a single photoperiodic cycle inducing flowering in Sinapis alba. Plant J. 2009;59:962-73 pubmed publisher
    ..These patterns are integrated with previous observations concerning upregulation of SUPPRESSOR OF OVEREXPRESSION OF CO1 (SaSOC1) to provide a temporal and spatial map of floral transition in Sinapis...
  42. Van Damme P, Evjenth R, Foyn H, Demeyer K, De Bock P, Lillehaug J, et al. Proteome-derived peptide libraries allow detailed analysis of the substrate specificities of N(alpha)-acetyltransferases and point to hNaa10p as the post-translational actin N(alpha)-acetyltransferase. Mol Cell Proteomics. 2011;10:M110.004580 pubmed publisher
    ..Thus, complex formation of NatA might alter the substrate specificity profile as compared with its isolated catalytic subunits, and, furthermore, NatA or hNaa10p may function as a post-translational actin N(α)-acetyltransferase. ..
  43. Billiet L, Geerlings P, Messens J, Roos G. The thermodynamics of thiol sulfenylation. Free Radic Biol Med. 2012;52:1473-85 pubmed publisher
    ..The REE method is not limited to thiol sulfenylation, but can be broadly applied to understand protein redox biology in general. ..
  44. Nguyen Duc T, Peeters E, Muyldermans S, Charlier D, Hassanzadeh Ghassabeh G. Nanobody(R)-based chromatin immunoprecipitation/micro-array analysis for genome-wide identification of transcription factor DNA binding sites. Nucleic Acids Res. 2013;41:e59 pubmed publisher
  45. Mc Guire C, Wieghofer P, Elton L, Muylaert D, Prinz M, Beyaert R, et al. Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination. J Immunol. 2013;190:2896-903 pubmed publisher
    ..Together, our data indicate that MALT1 may be an interesting therapeutic target in the treatment of multiple sclerosis. ..
  46. Dams E, De Wolf M, Dierick W. Nucleotide sequence analysis of the CT operon of the Vibrio cholerae classical strain 569B. Biochim Biophys Acta. 1991;1090:139-41 pubmed
    ..The results prove the exactness of the amino acid CT B sequence published by Takao et al. (1985, Eur. J. Biochem. 146, 503-508). A comparison is made with already reported CT genes. ..
  47. Van Ostade X, Tavernier J, Prange T, Fiers W. Localization of the active site of human tumour necrosis factor (hTNF) by mutational analysis. EMBO J. 1991;10:827-36 pubmed
    ..Our results favor a model in which each TNF molecule has three receptor-interaction sites (between the three subunits), thus allowing signal transmission by receptor clustering. ..
  48. Van Beeumen J, Van Kuilenburg A, Van Bun S, Van den Bogert C, Tager J, Muijsers A. Demonstration of two isoforms of subunit VIIa of cytochrome c oxidase from human skeletal muscle. Implications for mitochondrial myopathies. FEBS Lett. 1990;263:213-6 pubmed
    ..These findings may have important implications for the elucidation of genetic diseases in man in which a deficiency of cytochrome c oxidase is restricted to certain tissues. ..
  49. Foury F. Cloning and sequencing of the nuclear gene MIP1 encoding the catalytic subunit of the yeast mitochondrial DNA polymerase. J Biol Chem. 1989;264:20552-60 pubmed
    ..4) The MIP1 protein exhibits sequence similarities with both eukaryotic nuclear DNA polymerases and reverse transcriptases. There is no significant resemblance with prokaryotic DNA polymerases. ..
  50. Dartois V, De Backer O, Colson C. Sequence of the Salmonella typhimurium StyLT1 restriction-modification genes: homologies with EcoP1 and EcoP15 type-III R-M systems and presence of helicase domains. Gene. 1993;127:105-10 pubmed
    ..In addition, the StyLT1 restriction endonuclease (ENase), like other type-I and type-III ENases, contains sequence motifs characteristic of superfamily-II helicases, which may be involved in DNA unwinding at the cleavage site. ..
  51. Marine J, Bellefroid E, Pendeville H, Martial J, Pieler T. A role for Xenopus Gli-type zinc finger proteins in the early embryonic patterning of mesoderm and neuroectoderm. Mech Dev. 1997;63:211-25 pubmed
  52. Eggermont J. The exon-intron architecture of human chloride channel genes is not conserved. Biochim Biophys Acta. 1998;1397:156-60 pubmed
    ..Thus, the CLCN6 type of alternative splicing and the ensuing structural diversity is not conserved within the CLC gene family. ..
  53. Van Laer L, Huizing E, Verstreken M, van Zuijlen D, Wauters J, Bossuyt P, et al. Nonsyndromic hearing impairment is associated with a mutation in DFNA5. Nat Genet. 1998;20:194-7 pubmed
    ..The mutation co-segregated with deafness in the family and causes skipping of exon 8, resulting in premature termination of the open reading frame. As no physiological function could be assigned, the gene was designated DFNA5. ..
  54. Amery L, Brees C, Baes M, Setoyama C, Miura R, Mannaerts G, et al. C-terminal tripeptide Ser-Asn-Leu (SNL) of human D-aspartate oxidase is a functional peroxisome-targeting signal. Biochem J. 1998;336 ( Pt 2):367-71 pubmed
  55. Duez C, Thamm I, Sapunaric F, Coyette J, Ghuysen J. The division and cell wall gene cluster of Enterococcus hirae S185. DNA Seq. 1998;9:149-61 pubmed
    ..coli encode the ligases Ddl, MurC, MurE and MurF and the integral membrane protein FtsW. The encoded E. hirae and E. coli proteins share 25% to 50% identity except FtsL and FtsQ (approximately = 14% identity). ..
  56. van Grunsven L, Papin C, Avalosse B, Opdecamp K, Huylebroeck D, Smith J, et al. XSIP1, a Xenopus zinc finger/homeodomain encoding gene highly expressed during early neural development. Mech Dev. 2000;94:189-93 pubmed
    ..At later stages of development transcripts are detected primarily within the neural tube and neural crest. In the adult, XSIP1 expression is detected at variable levels in several organs. ..
  57. Georlette D, Jónsson Z, Van Petegem F, Chessa J, Van Beeumen J, Hubscher U, et al. A DNA ligase from the psychrophile Pseudoalteromonas haloplanktis gives insights into the adaptation of proteins to low temperatures. Eur J Biochem. 2000;267:3502-12 pubmed
    ..Besides being useful for investigation of the adaptation of enzymes to extreme temperatures, P. haloplanktis DNA ligase, which is very efficient at low temperatures, offers a novel tool for biotechnology. ..
  58. Nilius B, Vennekens R, Prenen J, Hoenderop J, Droogmans G, Bindels R. The single pore residue Asp542 determines Ca2+ permeation and Mg2+ block of the epithelial Ca2+ channel. J Biol Chem. 2001;276:1020-5 pubmed publisher
    ..Mutations of two neighboring negatively charged residues, i.e. Glu(535) and Asp(550), had only minor effects on Ca(2+) permeation properties...
  59. Lambeir A, Proost P, Durinx C, Bal G, Senten K, Augustyns K, et al. Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family. J Biol Chem. 2001;276:29839-45 pubmed
    ..The data not only provide insight into the selectivity of the enzyme for specific chemokines, but they also contribute to the general understanding of CD26/dipeptidyl peptidase IV secondary substrate specificity. ..
  60. Chen Y, Vandenbussche F, Rouge P, Proost P, Peumans W, Van Damme E. A complex fruit-specific type-2 ribosome-inactivating protein from elderberry (Sambucus nigra) is correctly processed and assembled in transgenic tobacco plants. Eur J Biochem. 2002;269:2897-906 pubmed
    ..Bioassays further demonstrated that none of the transgenic lines exhibited a decreased sensitivity to infection with tobacco mosaic virus suggesting that the elderberry type-2 RIP SNA-If does not act as an antiviral agent in planta...
  61. Conway E, Van de Wouwer M, Pollefeyt S, Jurk K, Van Aken H, De Vriese A, et al. The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogen-activated protein kinase pathways. J Exp Med. 2002;196:565-77 pubmed
    ..These data suggest that TM has antiinflammatory properties in addition to its role in coagulation and fibrinolysis. ..
  62. Heyninck K, Kreike M, Beyaert R. Structure-function analysis of the A20-binding inhibitor of NF-kappa B activation, ABIN-1. FEBS Lett. 2003;536:135-40 pubmed
    ..These results suggest that A20 and ABIN-1 probably act independently of their mutual interaction. ..
  63. Van Langenhove T, Van der Zee J, Sleegers K, Engelborghs S, Vandenberghe R, Gijselinck I, et al. Genetic contribution of FUS to frontotemporal lobar degeneration. Neurology. 2010;74:366-71 pubmed publisher
    ..At this point, the biologic relevance of this mutation remains elusive. Screening of additional FTLD patient cohorts will be needed to further elucidate the contribution of FUS mutations to FTLD pathogenesis. ..
  64. Zimon M, Baets J, Auer Grumbach M, Berciano J, Garcia A, Lopez Laso E, et al. Dominant mutations in the cation channel gene transient receptor potential vanilloid 4 cause an unusual spectrum of neuropathies. Brain. 2010;133:1798-809 pubmed publisher
    ..This finding is relatively unusual in the context of hereditary neuropathies and has important implications for diagnostic testing and genetic counselling. ..
  65. Van den Ende W, Coopman M, Clerens S, Vergauwen R, Le Roy K, Lammens W, et al. Unexpected presence of graminan- and levan-type fructans in the evergreen frost-hardy eudicot Pachysandra terminalis (Buxaceae): purification, cloning, and functional analysis of a 6-SST/6-SFT enzyme. Plant Physiol. 2011;155:603-14 pubmed publisher
    ..Our data suggest that the fructan syndrome in P. terminalis can be considered as a recent evolutionary event. Putative connections between abiotic stress and fructans are discussed...
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