Genomes and Genes
Experts and Doctors on amino acid sequence in Australia
Topic: amino acid sequence
Publications236 found, 100 shown here
- Li Q, Hobbs M, Reeves P. The variation of dTDP-L-rhamnose pathway genes in Vibrio cholerae. Microbiology. 2003;149:2463-74 pubmed publisher..cholerae. The sequence relationships make it possible to identify sites of recombination and to distinguish DNA that has long been in V. cholerae and DNA that probably came into the species with the O antigen gene cluster...
- Khan A, Williams K, Molloy M, Nevalainen H. Purification and characterization of a serine protease and chitinases from Paecilomyces lilacinus and detection of chitinase activity on 2D gels. Protein Expr Purif. 2003;32:210-20 pubmed..Two of the proteins had similarities with endochitinases as shown by their N-terminal amino acid sequences. ..
- Menzies M, Ingham A. Identification and expression of Toll-like receptors 1-10 in selected bovine and ovine tissues. Vet Immunol Immunopathol. 2006;109:23-30 pubmed publisher..In bovine skin TLRs 2 and 7 were most abundant. In all tissues tested TLR4 expression was at the lower limit of detection...
- Shipman K, Robinson P, King B, Smith R, Nicholson R. Identification of a family of DNA-binding proteins with homology to RNA splicing factors. Biochem Cell Biol. 2006;84:9-19 pubmed..The 3 human CREAP proteins form a unique family with the potential to act as transcription factors that link to RNA processing. ..
- Hussain M, Asgari S. Inhibition of apoptosis by Heliothis virescens ascovirus (HvAV-3e): characterization of orf28 with structural similarity to inhibitor of apoptosis proteins. Apoptosis. 2008;13:1417-26 pubmed publisher..Nevertheless, RNA interference studies revealed that the gene is probably essential for virus pathology and replication...
- Kovalchuk N, Smith J, Pallotta M, Singh R, Ismagul A, Eliby S, et al. Characterization of the wheat endosperm transfer cell-specific protein TaPR60. Plant Mol Biol. 2009;71:81-98 pubmed publisher..Examination of a three dimensional model of TaPR60 suggested that this protein could be involved in binding of lipidic molecules. ..
- Chen S, Kurdyukov S, Kereszt A, Wang X, Gresshoff P, Rose R. The association of homeobox gene expression with stem cell formation and morphogenesis in cultured Medicago truncatula. Planta. 2009;230:827-40 pubmed publisher..In relation to SE, a role for WUS in the signalling involved in induction is discussed. ..
- Khan J, Ranganathan S. A multi-species comparative structural bioinformatics analysis of inherited mutations in alpha-D-mannosidase reveals strong genotype-phenotype correlation. BMC Genomics. 2009;10 Suppl 3:S33 pubmed publisher..The current study has identified five mutational hot-spot regions along the MAN2B1 gene. Structural mapping can thus provide a rational approach for predicting the phenotype of a disease, based on observed genotypic variations. ..
- Li N, Yun P, Jeffries C, Langley D, Gamsjaeger R, Church W, et al. The modular structure of haemagglutinin/adhesin regions in gingipains of Porphyromonas gingivalis. Mol Microbiol. 2011;81:1358-73 pubmed publisher..The data indicate replication of some biological functions over the three adhesin domains of Kgp while other functions are restricted. ..
- Dear T, Kefford R. The WDNM1 gene product is a novel member of the 'four-disulphide core' family of proteins. Biochem Biophys Res Commun. 1991;176:247-54 pubmed..Possible modulation in the level of this protein product could be related to overall proteinase activity of specific tumour cells which, in turn, could influence the invasive and metastatic potential of such cell populations. ..
- Chapman G, Rathjen P. Sequence and evolutionary conservation of the murine Gbx-2 homeobox gene. FEBS Lett. 1995;364:289-92 pubmed..The homeodomain differs at only three positions out of 60 and these can be used to subdivide the GBX class homeodomains into 2 sub-classes. ..
- Hailstones D, Gunning P. Regulation of nonmuscle myosin light chain 3 gene expression in response to exogenous MLC3nm mRNA. Cell Mol Biol Res. 1994;40:53-62 pubmed..The down regulation of the mRNA for endogenous isoform is not detected at low cell density, suggesting that the mechanism may be density dependent and related to myoblast differentiation. ..
- Lackmann M, Rajasekariah P, Iismaa S, Jones G, Cornish C, Hu S, et al. Identification of a chemotactic domain of the pro-inflammatory S100 protein CP-10. J Immunol. 1993;150:2981-91 pubmed
- Wood S, Pascoe W, Ru K, Yamada T, Hirchenhain J, Kemler R, et al. Cloning and expression analysis of a novel mouse gene with sequence similarity to the Drosophila fat facets gene. Mech Dev. 1997;63:29-38 pubmed..The strong sequence similarity to faf and the developmentally regulated expression pattern suggest that Fam and the ubiquitin pathway may play a role in determining cell fate in mammals, as has been established for Drosophila. ..
- Martin L, Shewan A, Millar C, Gould G, James D. Vesicle-associated membrane protein 2 plays a specific role in the insulin-dependent trafficking of the facilitative glucose transporter GLUT4 in 3T3-L1 adipocytes. J Biol Chem. 1998;273:1444-52 pubmed..These results suggest that the N terminus of VAMP2 plays a unique role in the insulin-dependent recruitment of GLUT4 from its intracellular storage compartment to the cell surface. ..
- Gecz J, Baker E, Donnelly A, Ming J, McDonald McGinn D, Spinner N, et al. Fibroblast growth factor homologous factor 2 (FHF2): gene structure, expression and mapping to the Börjeson-Forssman-Lehmann syndrome region in Xq26 delineated by a duplication breakpoint in a BFLS-like patient. Hum Genet. 1999;104:56-63 pubmed..The FHF2 gene localisation and tissue-specific expression pattern suggest it to be a candidate gene for familial cases of the BFLS syndrome and other syndromal and non-specific forms of X-linked mental retardation mapping to the region. ..
- Cowley J, Dimmock C, Spann K, Walker P. Detection of Australian gill-associated virus (GAV) and lymphoid organ virus (LOV) of Penaeus monodon by RT-nested PCR. Dis Aquat Organ. 2000;39:159-67 pubmed..The speed and sensitivity of the RT-nPCR make it a useful adjunct to TEM for diagnosing LOV/GAV infection of P. monodon, with the additional benefit that screening of gill biopsies may facilitate selection of LOV-free broodstock. ..
- Huang A, Scougall C, Lowenthal J, Jilbert A, Kotlarski I. Structural and functional homology between duck and chicken interferon-gamma. Dev Comp Immunol. 2001;25:55-68 pubmed..These findings indicate that DuIFN-gamma shares structural and functional identity with ChIFN-gamma, which is consistent with our previous results which demonstrated cross reactivity with other lymphokines from the two species. ..
- Hulett M, Hornby J, Ohms S, Zuegg J, Freeman C, Gready J, et al. Identification of active-site residues of the pro-metastatic endoglycosidase heparanase. Biochemistry. 2000;39:15659-67 pubmed..These data suggest that heparanase is a member of the clan A glycosyl hydrolases and has a common catalytic mechanism that involves two conserved acidic residues, a putative proton donor at Glu(225) and a nucleophile at Glu(343). ..
- Groth C, Nornes S, McCarty R, Tamme R, Lardelli M. Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene presenilin2. Dev Genes Evol. 2002;212:486-90 pubmed..pre2 expression is especially high in neural-crest-derived melanocytes. ..
- Heras B, Edeling M, Schirra H, Raina S, Martin J. Crystal structures of the DsbG disulfide isomerase reveal an unstable disulfide. Proc Natl Acad Sci U S A. 2004;101:8876-81 pubmed..This finding suggests that, rather than catalyzing disulfide rearrangement in unfolded substrates, DsbG may preferentially act later in the folding process to catalyze disulfide rearrangement in folded or partially folded proteins. ..
- Zhang Q, Hrmova M, Shirley N, Lahnstein J, Fincher G. Gene expression patterns and catalytic properties of UDP-D-glucose 4-epimerases from barley (Hordeum vulgare L.). Biochem J. 2006;394:115-24 pubmed..A three-dimensional model of the HvUGE revealed that its overall structural fold is highly conserved compared with the human UGE and provides a structural rationale for its ability to bind UDP-GlcNAc. ..
- O Neil S, Heinrich T, Hales B, Hazell L, Holt D, Fischer K, et al. The chitinase allergens Der p 15 and Der p 18 from Dermatophagoides pteronyssinus. Clin Exp Allergy. 2006;36:831-9 pubmed..farinae chitinase allergens Der f 15 and Der f 18 and not to the groups 1 and 2 allergens as found for humans. Although the IgE response of humans to Der f 18 has been investigated there is no report on Der f 15-specific IgE in humans...
- Kubota T, Lewis B, Elliot D, Mackenzie P, Miners J. Critical roles of residues 36 and 40 in the phenol and tertiary amine aglycone substrate selectivities of UDP-glucuronosyltransferases 1A3 and 1A4. Mol Pharmacol. 2007;72:1054-62 pubmed..Thus, residues 36 and 40 of UGT1A3 and UGT1A4 are pivotal for the respective selectivities of these enzymes toward planar phenols and tertiary amines, although other regions of the proteins influence binding affinity and/or turnover. ..
- Kim M, Hamilton S, Guddat L, Overall C. Plant collagenase: unique collagenolytic activity of cysteine proteases from ginger. Biochim Biophys Acta. 2007;1770:1627-35 pubmed..The results support a role for ginger proteases as an alternative to papain, in commercial applications such as meat tenderization, where collagen is the target substrate. ..
- Zhou Y, Setz N, Niemietz C, Qu H, Offler C, Tyerman S, et al. Aquaporins and unloading of phloem-imported water in coats of developing bean seeds. Plant Cell Environ. 2007;30:1566-77 pubmed..The functional significance of aquaporins in nutrient and water transport in developing seeds is discussed. ..
- Lynagh T, Lynch J. A glycine residue essential for high ivermectin sensitivity in Cys-loop ion channel receptors. Int J Parasitol. 2010;40:1477-81 pubmed publisher..By providing a means of identifying ivermectin-sensitive receptors, this finding should help in characterising ivermectin-resistance mechanisms and identifying new anthelmintic targets. ..
- Parkin J, San Antonio J, Pedchenko V, Hudson B, Jensen S, Savige J. Mapping structural landmarks, ligand binding sites, and missense mutations to the collagen IV heterotrimers predicts major functional domains, novel interactions, and variation in phenotypes in inherited diseases affecting basement membranes. Hum Mutat. 2011;32:127-43 pubmed publisher..These maps further our understanding of basement membrane biology and disease, and suggest novel membrane interactions, functions, and therapeutic targets. ..
- Tu E, Waterhouse L, Duflou J, Bagnall R, Semsarian C. Genetic analysis of hyperpolarization-activated cyclic nucleotide-gated cation channels in sudden unexpected death in epilepsy cases. Brain Pathol. 2011;21:692-8 pubmed publisher..Our results support a pathogenic link between the heart and brain in SUDEP, mediated by the HCN neuro-cardiac ion channel genes. ..
- Rashid M, Newton M, Hoque M, Shatabda S, Pham D, Sattar A. Spiral search: a hydrophobic-core directed local search for simplified PSP on 3D FCC lattice. BMC Bioinformatics. 2013;14 Suppl 2:S16 pubmed publisher..The experimental results show that our spiral search algorithm outperforms the state-of-the-art local search algorithms for simplified protein structure prediction. We also experimentally show the effectiveness of the relay-restart. ..
- Ogierman M, Manning P. TCP pilus biosynthesis in Vibrio cholerae O1: gene sequence of tcpC encoding an outer membrane lipoprotein. FEMS Microbiol Lett. 1992;76:179-84 pubmed..Together with the lipoprotein signal sequence and the several hydrophobic domains it seems likely that TcpC is a surface-anchored trans-outer membrane lipoprotein. ..
- Faast R, Ogierman M, Stroeher U, Manning P. Nucleotide sequence of the structural gene, tcpA, for a major pilin subunit of Vibrio cholerae. Gene. 1989;85:227-31 pubmed..The TcpA protein shows some similarities to the major pilins of the methylated phenylalanine type or type-4 pili from other bacteria; however, it is sufficiently different that it may represent a new class...
- Sun J, Coughlin P, Salem H, Bird P. Production and characterization of recombinant human proteinase inhibitor 6 expressed in Pichia pastoris. Biochim Biophys Acta. 1995;1252:28-34 pubmed..No complex formation was observed with chymotrypsin, human leukocyte elastase, cathepsin G and tissue plasminogen activator, although PI-6 is apparently a substrate for chymotrypsin, leukocyte elastase and cathepsin G. ..
- Keightley M, Fuller P. Unique sequences in the guinea pig glucocorticoid receptor induce constitutive transactivation and decrease steroid sensitivity. Mol Endocrinol. 1994;8:431-9 pubmed..abstract truncated at 250 words) ..
- Sturm R, O Sullivan B, Box N, Smith A, Smit S, Puttick E, et al. Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family. Genomics. 1995;29:24-34 pubmed..The evidence also suggests that at least some of the introns within the TYR, TYRP1, and TYRP2 coding regions were gained after duplication and that intron slippage is unlikely to have occurred. ..
- Chang A, Dunham M, Jeffrey K, Reddel R. Molecular cloning and characterization of mouse stanniocalcin cDNA. Mol Cell Endocrinol. 1996;124:185-7 pubmed..As in human, the mRNA is expressed in many mouse tissues, suggesting that mammalian stanniocalcin has a paracrine rather than endocrine role. ..
- Chadwick B, Coelen R, Wilcox G, Sammels L, Kertayadnya G. Nucleotide sequence analysis of Jembrana disease virus: a bovine lentivirus associated with an acute disease syndrome. J Gen Virol. 1995;76 ( Pt 7):1637-50 pubmed..The significance of these changes is discussed in relation to the differences in pathogenicity between JDV and BIV...
- Schenk G, Layfield R, Candy J, Duggleby R, Nixon P. Molecular evolutionary analysis of the thiamine-diphosphate-dependent enzyme, transketolase. J Mol Evol. 1997;44:552-72 pubmed..Transketolase appears to be an ancient enzyme that has evolved slowly and might serve as a model for a molecular clock, at least within the mammalian clade. ..
- Aldred A, Prapunpoj P, Schreiber G. Evolution of shorter and more hydrophilic transthyretin N-termini by stepwise conversion of exon 2 into intron 1 sequences (shifting the 3' splice site of intron 1). Eur J Biochem. 1997;246:401-9 pubmed..Successive shifts in splice sites may be an evolutionary mechanism of general importance, since they can lead to stepwise changes in the properties of proteins. This could be a molecular mechanism for positive Darwinian selection. ..
- Ziman M, Fletcher S, Kay P. Alternate Pax7 transcripts are expressed specifically in skeletal muscle, brain and other organs of adult mice. Int J Biochem Cell Biol. 1997;29:1029-36 pubmed..It is possible that one of these transcripts may specify an alternate myogenic pathway involved in regeneration of damaged skeletal muscle in adult mice. ..
- Brinkworth R, Tort J, Brindley P, Dalton J. Phylogenetic relationships and theoretical model of human cathepsin W (lymphopain), a cysteine proteinase from cytotoxic T lymphocytes. Int J Biochem Cell Biol. 2000;32:373-84 pubmed..The signature residues of the cruzipain lineage are (cruzipain numbering) Asn 33, Trp 38, Ala 124, Leu 127, Leu 164, and Pro 174. ..
- Millar A, Mittova V, Kiddle G, Heazlewood J, Bartoli C, Theodoulou F, et al. Control of ascorbate synthesis by respiration and its implications for stress responses. Plant Physiol. 2003;133:443-7 pubmed
- Curry B, Roman S, Wallace C, Scott R, Miriami E, Aitken R. Identification and characterization of a novel splice variant of mouse and rat cytochrome b5/cytochrome b5 reductase. Genomics. 2004;83:425-38 pubmed..We postulate that cb5/cb5rdelta12 may function in a dominant negative fashion, limiting the amount of damage caused by the production of reactive oxygen species by cb5/cb5r. ..
- Robinson A, Wu P, Harrop S, Schaeffer P, Dosztanyi Z, Gillings M, et al. Integron-associated mobile gene cassettes code for folded proteins: the structure of Bal32a, a new member of the adaptable alpha+beta barrel family. J Mol Biol. 2005;346:1229-41 pubmed..These studies demonstrate the viability of direct sampling of mobile DNA as a route for the discovery of novel proteins. ..
- Subbiah R, Kondo M, Campbell T, Vandenberg J. Tryptophan scanning mutagenesis of the HERG K+ channel: the S4 domain is loosely packed and likely to be lipid exposed. J Physiol. 2005;569:367-79 pubmed..Further, we identified residues K525, R528 and K538 as being the most important for slow activation of the channels. ..
- Blackman L, Mitchell H, Hardham A. Characterisation of manganese superoxide dismutase from Phytophthora nicotianae. Mycol Res. 2005;109:1171-83 pubmed..Southern blots indicated that there is one copy of PnMnSOD2 in the P. nicotianae genome. PnMnSOD2 was expressed at similar levels in mycelia and germinated cysts but PnMnSOD2 transcripts were not detectable in zoospores. ..
- Kamhieh S, Hodgson J, Bode L, Ludwig H, Ward C, Flower R. No evidence of endemic Borna disease virus infection in Australian horses in contrast with endemic infection in other continents. Arch Virol. 2006;151:709-19 pubmed..7%) displaying low range positive results in the CIC assay, and no detectable BDV RNA. This pattern is inconsistent with endemic BDV infection and strongly contrasts with the pattern of endemic infection, particularly in Europe. ..
- Amon M, Ali M, Bender V, Chan Y, Toth I, Manolios N. Lipidation and glycosylation of a T cell antigen receptor (TCR) transmembrane hydrophobic peptide dramatically enhances in vitro and in vivo function. Biochim Biophys Acta. 2006;1763:879-88 pubmed..This study demonstrates that hydrophobic peptide activity is markedly enhanced in vitro and in vivo by conjugation to lipids or sugars. This may have practical applications in drug delivery and bioavailability of hydrophobic peptides. ..
- Vajjhala P, Catchpoole E, Nguyen C, Kistler C, Munn A. Vps4 regulates a subset of protein interactions at the multivesicular endosome. FEBS J. 2007;274:1894-907 pubmed..Our studies indicate that the MIT domain has a dual role in substrate binding and recruitment to endosomes and indicate that Vps4 disassembles the MVB sorting machinery by direct effects on multiple proteins. ..
- Ball H, Sanchez Perez A, Weiser S, Austin C, Astelbauer F, Miu J, et al. Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice. Gene. 2007;396:203-13 pubmed..This identification of INDOL1 may help to explain the regulation of the diversity of physiological and patho-physiological processes in which the kynurenine pathway is involved. ..
- Mitchell D, Minchin R. Cytosolic Aryl sulfotransferase 4A1 interacts with the peptidyl prolyl cis-trans isomerase Pin1. Mol Pharmacol. 2009;76:388-95 pubmed publisher..These modifications may also be important for enzyme activity, which explains why specific substrates for SULT4A1 have not yet been identified. ..
- Lau Q, Jobbins S, Belov K, Higgins D. Characterisation of four major histocompatibility complex class II genes of the koala (Phascolarctos cinereus). Immunogenetics. 2013;65:37-46 pubmed publisher..We detected greater variation in the ?1 than in the ?1 domains as well as evidence of positive selection in DAB. The present study provides a springboard to future investigation of the role of MHC in disease susceptibility in koalas...
- Lee P, Yeo G, Weiss A. A cell adhesive peptide from tropoelastin promotes sequential cell attachment and spreading via distinct receptors. FEBS J. 2017;284:2216-2230 pubmed publisher..We conclude that this region comprises a tropoelastin-derived, cell-interactive sequence that independently mediates potent cell binding and spreading via sequential recognition of GAG and integrin cell surface receptors. ..
- Robin C, Russell R, Medveczky K, Oakeshott J. Duplication and divergence of the genes of the alpha-esterase cluster of Drosophila melanogaster. J Mol Evol. 1996;43:241-52 pubmed..The distribution of indels also suggests a deeper node in the gene phylogeny that separates six genes at the two ends of the cluster from a block of five in the middle. ..
- Turner J, Crossley M. The CtBP family: enigmatic and enzymatic transcriptional co-repressors. Bioessays. 2001;23:683-90 pubmed..Supplementary material for this article can be found on the BioEssays homepage at http://www.interscience.wiley.com/jpages/0265-9247/suppmat/v23_8.684. ..
- Thia K, Trapani J. The granzyme B gene is highly polymorphic in wild mice but essentially invariant in common inbred laboratory strains. Tissue Antigens. 2007;70:198-204 pubmed..Unlike the protease, the extended granzyme B recognition and cleavage site in Bid, a key pro-apoptotic substrate, was invariant. ..
- Boucherot A, Schreiber R, Kunzelmann K. Regulation and properties of KCNQ1 (K(V)LQT1) and impact of the cystic fibrosis transmembrane conductance regulator. J Membr Biol. 2001;182:39-47 pubmed..Thus, KCNQ1 expressed in Xenopus oocytes is regulated by cAMP and Ca2+ but is not affected by CFTR. ..
- Hayward D, Samuel G, Pontynen P, Catmull J, Saint R, Miller D, et al. Localized expression of a dpp/BMP2/4 ortholog in a coral embryo. Proc Natl Acad Sci U S A. 2002;99:8106-11 pubmed..A localized source of DPP/BMP2/4 may have already been used in axis formation in this ancestor, or it may have provided a means by which an axis could evolve in triploblastic animals. ..
- Buckley M, Loveland K, McKinstry W, Garson O, Goding J. Plasma cell membrane glycoprotein PC-1. cDNA cloning of the human molecule, amino acid sequence, and chromosomal location. J Biol Chem. 1990;265:17506-11 pubmed..Southern blots suggest a single copy gene. In situ chromosomal hybridization localizes the gene for human PC-1 to chromosome 6q22-q23, a common site for deletions in human lymphoid neoplasia. ..
- Bröer A, Klingel K, Kowalczuk S, Rasko J, Cavanaugh J, Broer S. Molecular cloning of mouse amino acid transport system B0, a neutral amino acid transporter related to Hartnup disorder. J Biol Chem. 2004;279:24467-76 pubmed..Thus, the human homologue of this transporter is an excellent functional and positional candidate for Hartnup disorder...
- Ranjit N, Zhan B, Hamilton B, Stenzel D, Lowther J, Pearson M, et al. Proteolytic degradation of hemoglobin in the intestine of the human hookworm Necator americanus. J Infect Dis. 2009;199:904-12 pubmed..americanus involves a network of distinct proteases, some of which act in an ordered fashion, providing a potential mechanism by which some of these hemoglobinases exert their efficacy as recombinant vaccines against hookworm infection...
- Guddat L, Vos S, Martin J, Keough D, de Jersey J. Crystal structures of free, IMP-, and GMP-bound Escherichia coli hypoxanthine phosphoribosyltransferase. Protein Sci. 2002;11:1626-38 pubmed..However, hypoxanthine does not have a 2-exocyclic atom and the HPRT-IMP structure suggests that hypoxanthine is likely to occupy a different position in the purine-binding pocket. ..
- Blitvich B, Scanlon D, Shiell B, Mackenzie J, Hall R. Identification and analysis of truncated and elongated species of the flavivirus NS1 protein. Virus Res. 1999;60:67-79 pubmed..in 1998), suggesting that deltaNS1 may be a translation product of defective viral RNA. ..
- Herd K, Mahalingam S, Mackay I, Nissen M, Sloots T, Tindle R. Cytotoxic T-lymphocyte epitope vaccination protects against human metapneumovirus infection and disease in mice. J Virol. 2006;80:2034-44 pubmed..These results demonstrate for the first time the efficacy of an hMPV CTL epitope vaccine in the control of hMPV infection in a murine model. ..
- Fusaro A, Corrêa R, Nakasugi K, Jackson C, Kawchuk L, Vaslin M, et al. The Enamovirus P0 protein is a silencing suppressor which inhibits local and systemic RNA silencing through AGO1 degradation. Virology. 2012;426:178-87 pubmed publisher..Therefore, despite the lack of any sequence similarity, the poleroviral and enamoviral SSPs have a conserved mode of action upon the RNA silencing machinery...
- Tiwari R, Reeve W, Dilworth M, Glenn A. Acid tolerance in Rhizobium meliloti strain WSM419 involves a two-component sensor-regulator system. Microbiology. 1996;142 ( Pt 7):1693-704 pubmed publisher..These data implicate a two-component sensor-regulator protein pair in acid tolerance in R. meliloti and suggest their involvement in pH sensing and/or response by these bacteria...
- Cox T, Bawden M, Martin A, May B. Human erythroid 5-aminolevulinate synthase: promoter analysis and identification of an iron-responsive element in the mRNA. EMBO J. 1991;10:1891-902 pubmed..These results suggest that the IRE motif in the ALAS mRNA is functional and imply that translation of the mRNA is controlled by cellular iron availability during erythropoiesis. ..
- Bawden M, Borthwick I, Healy H, Morris C, May B, Elliott W. Sequence of human 5-aminolevulinate synthase cDNA. Nucleic Acids Res. 1987;15:8563 pubmed
- Bennetts J, Rendtorff N, Simpson F, Tranebjaerg L, Wicking C. The coding region of TP53INP2, a gene expressed in the developing nervous system, is not altered in a family with autosomal recessive non-progressive infantile ataxia on chromosome 20q11-q13. Dev Dyn. 2007;236:843-52 pubmed..Our failure to detect causative mutations suggests that alterations in the coding region of TP53INP2 are not responsible for ataxia in this family, although we cannot rule out changes in non-coding elements of this gene. ..
- Dalrymple B, Swadling Y, Cybinski D, Xue G. Cloning of a gene encoding cinnamoyl ester hydrolase from the ruminal bacterium Butyrivibrio fibrisolvens E14 by a novel method. FEMS Microbiol Lett. 1996;143:115-20 pubmed..cellulosa, is not similar to CinI. CinI was expressed at high levels in the periplasmic fraction of E. coli TOPP2 and released ferulic acid from Fara [5-O-(trans-feruloyl)-arabinofuranose] prepared from wheat bran. ..
- Li D, Blasevich F, Theopold U, Schmidt O. Possible function of two insect phospholipid-hydroperoxide glutathione peroxidases. J Insect Physiol. 2003;49:1-9 pubmed..A possible function of a non-enzymatic extracellular PHGPx-like protein is discussed. ..
- Daly K, Digby M, Lefevre C, Mailer S, Thomson P, Nicholas K, et al. Analysis of the expression of immunoglobulins throughout lactation suggests two periods of immune transfer in the tammar wallaby (Macropus eugenii). Vet Immunol Immunopathol. 2007;120:187-200 pubmed..These two periods coincide with the birth of the young, and with its first emergence from the pouch. This increased expression may represent a strategy for maternal immunological protection of the pouch young. ..
- Sharma S, Dimasi D, Higginson K, Della N. RZF, a zinc-finger protein in the photoreceptors of human retina. Gene. 2004;342:219-29 pubmed
- Chan L, Wang C, Major J, Greenwood K, Lewis R, Craik D, et al. Isolation and characterization of peptides from Momordica cochinchinensis seeds. J Nat Prod. 2009;72:1453-8 pubmed publisher..Of the cell lines tested, MCoCC-1 is the most toxic against a human melanoma cell line (MM96L) and is nonhemolytic to human erythrocytes. The role of these peptides within the plant remains to be determined...
- Hime G, Lada H, Fietz M, Gillies S, Passmore A, Wicking C, et al. Functional analysis in Drosophila indicates that the NBCCS/PTCH1 mutation G509V results in activation of smoothened through a dominant-negative mechanism. Dev Dyn. 2004;229:780-90 pubmed..Another mutation at the same residue, G509R, did not exhibit dominant-negative activity, suggesting that simple removal of the glycine at 509 is not sufficient to impart dominant-negative function. ..
- Dun E, Hanan J, Beveridge C. Computational modeling and molecular physiology experiments reveal new insights into shoot branching in pea. Plant Cell. 2009;21:3459-72 pubmed publisher..Furthermore, we propose xylem-sap cytokinin promotes sustained bud outgrowth, rather than acting at the earlier stage of bud release. ..
- Tellam J, McIntosh S, James D. Molecular identification of two novel Munc-18 isoforms expressed in non-neuronal tissues. J Biol Chem. 1995;270:5857-63 pubmed..It is likely, based on these findings, that unique Munc-18/syntaxin interactions may play an important role in generating a combinatorial mechanism for the regulation of vesicle transport in mammalian cells. ..
- Weber B, Blanch L, Clements P, Scott H, Hopwood J. Cloning and expression of the gene involved in Sanfilippo B syndrome (mucopolysaccharidosis III B). Hum Mol Genet. 1996;5:771-7 pubmed..This will allow correction studies with NAG deficient Sanfilippo B cell lines and facilitate the development of enzyme replacement therapy for these patients. ..
- Dhillon J, Cowley J, Wang Y, Walker P. RNA polymerase (L) gene and genome terminal sequences of ephemeroviruses bovine ephemeral fever virus and Adelaide River virus indicate a close relationship to vesiculoviruses. Virus Res. 2000;70:87-95 pubmed..An extended phylogenetic analysis using the block III sequence, confirmed the relationship of these ephemeroviruses to vesiculo- and lyssaviruses and to other single-stranded (-) RNA viruses...
- Kenning M, Gentle A, McBrien N. Expression and cDNA sequence of matrix metalloproteinase-2 (MMP-2) in a mammalian model of human disease processes: Tupaia belangeri. DNA Seq. 2004;15:332-7 pubmed..The tree shrew is a species close to the primate line and is an emerging animal model for a variety of human diseases, including hepatitis and myopia that feature MMP-2 mediated remodelling of the extracellular matrix...
- Craik D, Daly N. NMR as a tool for elucidating the structures of circular and knotted proteins. Mol Biosyst. 2007;3:257-65 pubmed..In this review the role of NMR in defining the structures of cyclotides is described. ..
- Upton Z, Webb H, Hale K, Yandell C, McMurtry J, Francis G, et al. Identification of vitronectin as a novel insulin-like growth factor-II binding protein. Endocrinology. 1999;140:2928-31 pubmed
- Brymora A, Valova V, Larsen M, Roufogalis B, Robinson P. The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene. J Biol Chem. 2001;276:29792-7 pubmed..Phospholipase D bound RalA in a nucleotide-independent manner. This places the RalA signaling system in mammalian nerve terminals, where the exocyst may act as an effector for activated RalA in directing sites of exocytosis. ..
- Deane J, Mackay J, Kwan A, Sum E, Visvader J, Matthews J. Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4. EMBO J. 2003;22:2224-33 pubmed..These findings constitute the first molecular definition of LIM-mediated protein-protein interactions and suggest a mechanism by which ldb1 can bind a variety of LIM domains that share low sequence homology. ..
- Ma G, Roberts H, Sarjan M, Featherstone N, Lahnstein J, Akhurst R, et al. Is the mature endotoxin Cry1Ac from Bacillus thuringiensis inactivated by a coagulation reaction in the gut lumen of resistant Helicoverpa armigera larvae?. Insect Biochem Mol Biol. 2005;35:729-39 pubmed publisher..We propose a resistance mechanism against toxins based on a systemic immune-induction that can be transmitted to the next generation by a maternal effect...
- Scott N, Bogema D, Connolly A, Falconer L, Djordjevic S, Cordwell S. Mass spectrometric characterization of the surface-associated 42 kDa lipoprotein JlpA as a glycosylated antigen in strains of Campylobacter jejuni. J Proteome Res. 2009;8:4654-64 pubmed publisher..This is the first study to identify N-linked glycosylation of a surface-exposed C. jejuni virulence factor and to show strain variation in glycosylation sites. ..
- Loudon J, Loughlin R. Mutagenesis and regulation of the cysJ promoter of Escherichia coli K-12. Gene. 1992;122:17-25 pubmed..By comparison of the sequences of four cys promoters, a possible CysB-binding site was found which included the region shown to be required for the positive regulation of the cysJ promoter. ..
- Thomas P, Johnson B, Rathjen J, Rathjen P. Sequence, genomic organization, and expression of the novel homeobox gene Hesx1. J Biol Chem. 1995;270:3869-75 pubmed..Expression in adult mice was not detected. These sites of expression are consistent with a role for Hesx1 in the regulation of developmental decisions in the early mouse embryo and during fetal hematopoiesis. ..