Experts and Doctors on amino acid sequence homology in United States


Locale: United States
Topic: amino acid sequence homology

Top Publications

  1. Likitvivatanavong S, Aimanova K, Gill S. Loop residues of the receptor binding domain of Bacillus thuringiensis Cry11Ba toxin are important for mosquitocidal activity. FEBS Lett. 2009;583:2021-30 pubmed publisher
    ..Cry11Ba binds the same regions to which anti-cadherin antibody binds, and this antibody competes with Cry11Ba binding suggesting a possible role of cadherin in toxication. ..
  2. Yuan C, Borchardt R. Photoaffinity labeling of human placental S-adenosylhomocysteine hydrolase with [2-3H]8-azido-adenosine. J Biol Chem. 1995;270:16140-6 pubmed
    ..The peptide Val319-Arg327 is adjacent to Leu330, which is proposed by a computer graphics model to interact with the C-6-NH2 group of Ado. ..
  3. Mahan S, McGuire T, Semu S, Bowie M, Jongejan F, Rurangirwa F, et al. Molecular cloning of a gene encoding the immunogenic 21 kDa protein of Cowdria ruminantium. Microbiology. 1994;140 ( Pt 8):2135-42 pubmed
    ..The antigenic conservation of the 21 kDa protein and its immunogenic nature are reasons for further testing of this recombinant protein in subunit diagnostic tests...
  4. Opperman T, Richardson J. Phylogenetic analysis of sequences from diverse bacteria with homology to the Escherichia coli rho gene. J Bacteriol. 1994;176:5033-43 pubmed
    ..Since functionally defective mutants for E. coli Rho exist in all three of these segments, they represent important parts of Rho that have undergone adaptive evolution...
  5. Strom M, Nunn D, Lory S. Posttranslational processing of type IV prepilin and homologs by PilD of Pseudomonas aeruginosa. Methods Enzymol. 1994;235:527-40 pubmed
    ..aeruginosa, such inhibitors may be useful tools in the study of the role these peptidases play in bacterial virulence. ..
  6. Rymond B. Convergent transcripts of the yeast PRP38-SMD1 locus encode two essential splicing factors, including the D1 core polypeptide of small nuclear ribonucleoprotein particles. Proc Natl Acad Sci U S A. 1993;90:848-52 pubmed
    ..These data establish Smd1p as a required component of the cellular splicing apparatus and a factor in snRNA maturation and stability. ..
  7. Liu T, Kim H, Arizmendi C, Kitano A, Patel M. Identification of two missense mutations in a dihydrolipoamide dehydrogenase-deficient patient. Proc Natl Acad Sci U S A. 1993;90:5186-90 pubmed
    ..The other point mutation was a nucleotide change from C to T, resulting in the substitution of Leu (CTG) for Pro-453 (CCG). These mutations appear to be significant in that they alter the active site and possibly the binding of FAD. ..
  8. Gayle M, Slack J, Bonnert T, Renshaw B, Sonoda G, Taguchi T, et al. Cloning of a putative ligand for the T1/ST2 receptor. J Biol Chem. 1996;271:5784-9 pubmed
    ..In searching for a ligand for T1/ST2, we have cloned a cell surface protein to which it binds. This protein is unable to initiate signal transduction by the T1/ST2 receptor in several in vitro assays. ..
  9. Croteau W, Davey J, Galton V, St Germain D. Cloning of the mammalian type II iodothyronine deiodinase. A selenoprotein differentially expressed and regulated in human and rat brain and other tissues. J Clin Invest. 1996;98:405-17 pubmed

More Information

Publications323 found, 100 shown here

  1. Matsui N, Sarkar G, Shuto T, Marrs J, Bronk J, Mizuno K, et al. Identification of a dual leucine zipper kinase involved in rat fracture repair. Biochem Biophys Res Commun. 1996;229:571-6 pubmed
    ..Since DLK has been shown to function in the mitogen activated signaling (MAP) pathway, these results provide the first evidence for the involvement of this signaling pathway in fracture healing. ..
  2. Blachly Dyson E, Song J, Wolfgang W, Colombini M, Forte M. Multicopy suppressors of phenotypes resulting from the absence of yeast VDAC encode a VDAC-like protein. Mol Cell Biol. 1997;17:5727-38 pubmed
    ..Thus, channel-forming activity does not seem to be either necessary or sufficient to restore growth on nonfermentable carbon sources, indicating that VDAC mediates cellular functions that do not depend on the ability to form channels. ..
  3. Cornell K, Riscoe M. Cloning and expression of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase: identification of the pfs gene product. Biochim Biophys Acta. 1998;1396:8-14 pubmed
    ..From this biochemical evidence we confirm our original assignment of the pfs gene as encoding MTA/SAH nucleosidase. ..
  4. Wang X, Smith D, Liu W, James C. GBAS, a novel gene encoding a protein with tyrosine phosphorylation sites and a transmembrane domain, is co-amplified with EGFR. Genomics. 1998;49:448-51 pubmed
    ..The associated amino acid sequence has identifiable signal peptide and transmembrane motifs, as well as two tyrosine phosphorylation sites that suggest that the encoded protein may be a substrate for tyrosine kinases. ..
  5. Wang C, Shi J, Davoodi Semiromi A, She J. Cloning of Aire, the mouse homologue of the autoimmune regulator (AIRE) gene responsible for autoimmune polyglandular syndrome type 1 (ASP1). Genomics. 1999;55:322-6 pubmed
    ..The coding region shares 77% nucleotide homology and 71% protein homology with human AIRE. As in its human homologue, Aire contains two PHD-type zinc-finger motifs, suggesting that the Aire protein may act as a transcription regulator. ..
  6. Sanchez M, Ullman B, Landfear S, Carter N. Cloning and functional expression of a gene encoding a P1 type nucleoside transporter from Trypanosoma brucei. J Biol Chem. 1999;274:30244-9 pubmed
    ..Genomic Southern blots suggest that there are multiple genes related in sequence to TbNT2, implying the existence of a family of nucleoside transporter genes in these parasites. ..
  7. Smith D, Renshaw B, Ketchem R, Kubin M, Garka K, Sims J. Four new members expand the interleukin-1 superfamily. J Biol Chem. 2000;275:1169-75 pubmed
    ..Protein structure modeling also suggests that the FIL1 genes are related to IL-1beta and IL-1ra. The novel genes form a cluster with the IL-1s on the long arm of human chromosome 2. ..
  8. West A, Llamas L, Snow P, Benzer S, Bjorkman P. Crystal structure of the ectodomain of Methuselah, a Drosophila G protein-coupled receptor associated with extended lifespan. Proc Natl Acad Sci U S A. 2001;98:3744-9 pubmed
    ..The Mth structure is analyzed in relation to predicted Mth homologs and potential ligand binding features. ..
  9. McGee J, Roe J, Sweat T, Wang X, Guikema J, Leach J. Rice phospholipase D isoforms show differential cellular location and gene induction. Plant Cell Physiol. 2003;44:1013-26 pubmed
    ..This combined information on structural features, expression profiles, and cellular localization will assist the basis for dissection of PLD isoform function in rice...
  10. Kim S, Mollet J, Dong J, Zhang K, Park S, Lord E. Chemocyanin, a small basic protein from the lily stigma, induces pollen tube chemotropism. Proc Natl Acad Sci U S A. 2003;100:16125-30 pubmed
    ..2 Da. Activity of the lily plantacyanin (named chemocyanin) is enhanced in the presence of stigma/stylar cysteine-rich adhesin, previously identified as a pollen tube adhesin in the lily style. ..
  11. Gagne J, Smalle J, Gingerich D, Walker J, Yoo S, Yanagisawa S, et al. Arabidopsis EIN3-binding F-box 1 and 2 form ubiquitin-protein ligases that repress ethylene action and promote growth by directing EIN3 degradation. Proc Natl Acad Sci U S A. 2004;101:6803-8 pubmed
    ..Collectively, our results show that the SCF(EBF1/EBF2)-dependent ubiquitination and subsequent removal of EIN3 is critical not only for proper ethylene signaling but also for growth in plants. ..
  12. Kerner J, Distler A, Minkler P, Parland W, Peterman S, Hoppel C. Phosphorylation of rat liver mitochondrial carnitine palmitoyltransferase-I: effect on the kinetic properties of the enzyme. J Biol Chem. 2004;279:41104-13 pubmed
    ..These observations identify a new mechanism for regulation of hepatic CPT-I by phosphorylation. ..
  13. Zito C, Antony E, Hunt J, Oliver D, Hingorani M. Role of a conserved glutamate residue in the Escherichia coli SecA ATPase mechanism. J Biol Chem. 2005;280:14611-9 pubmed
  14. Shao B, Fu X, McDonald T, Green P, Uchida K, O Brien K, et al. Acrolein impairs ATP binding cassette transporter A1-dependent cholesterol export from cells through site-specific modification of apolipoprotein A-I. J Biol Chem. 2005;280:36386-96 pubmed
    ..Thus, acrolein might contribute to atherogenesis by impairing cholesterol removal from the artery wall...
  15. Lee J, Bae E, Bingman C, Phillips G, Raines R. Structural basis for catalysis by onconase. J Mol Biol. 2008;375:165-77 pubmed
    ..No variant, however, was more toxic to human cancer cells than wild-type ONC. Together, these findings provide a cynosure for understanding catalysis of RNA cleavage in a system of high medicinal relevance. ..
  16. Komaba S, Coluccio L. Localization of myosin 1b to actin protrusions requires phosphoinositide binding. J Biol Chem. 2010;285:27686-93 pubmed publisher
    ..These results suggest that binding of Myo1b to phosphoinositides plays an important role in vivo by regulating localization to actin-enriched membrane projections. ..
  17. Margraf R, Roca A, Cox M. The deduced Vibrio cholerae RecA amino-acid sequence. Gene. 1995;152:135-6 pubmed
    ..The amino acid (aa) sequence of the protein product is very similar to other known RecA aa sequences. However, this sequence does not agree with a previously reported Vc RecA aa sequence [Ghosh et al., Nucleic Acids Res. 20 (1992) 372]...
  18. Henikoff S, Henikoff J. Protein family classification based on searching a database of blocks. Genomics. 1994;19:97-107 pubmed
    ..We also show how searching a database of blocks can be used to detect repeated domains and to find distinct cross-family relationships that were missed in searches of sequence databases. ..
  19. Li Y, Strohl W. Cloning, purification, and properties of a phosphotyrosine protein phosphatase from Streptomyces coelicolor A3(2). J Bacteriol. 1996;178:136-42 pubmed
    ..Apparent homologs of ptpA were detected in other streptomycetes by Southern hybridization; the biological functions of PtpA and its putative homologs in streptomycetes are not yet known. ..
  20. Wu J, Newton A. Isolation, identification, and transcriptional specificity of the heat shock sigma factor sigma32 from Caulobacter crescentus. J Bacteriol. 1996;178:2094-101 pubmed
    ..crescentus sigma32 appear to be very similar to those of its E. coli counterpart, the C. crescentus rpoH gene contains a novel promoter structure and may be positively autoregulated in response to environmental stress. ..
  21. Hammonds Odie L, Jackson T, Profit A, Blader I, Turck C, Prestwich G, et al. Identification and cloning of centaurin-alpha. A novel phosphatidylinositol 3,4,5-trisphosphate-binding protein from rat brain. J Biol Chem. 1996;271:18859-68 pubmed
    ..Given the specificity of binding and enrichment in brain, centaurin-alpha is a candidate PtdInsP3 receptor that may link the activation of phosphoinositide 3-kinase to downstream responses in the brain. ..
  22. Kelm R, Elder P, Strauch A, Getz M. Sequence of cDNAs encoding components of vascular actin single-stranded DNA-binding factor 2 establish identity to Puralpha and Purbeta. J Biol Chem. 1997;272:26727-33 pubmed
    ..This study implicates Puralpha and/or Purbeta in the control of vascular smooth muscle alpha-actin gene transcription. ..
  23. Ozols J. Determination of lumenal orientation of microsomal 50-kDa esterase/N-deacetylase. Biochemistry. 1998;37:10336-44 pubmed
    ..It is proposed here that such a motif may constitute a lumenal targeting signal for a set of single-membrane-spanning proteins that are otherwise structurally and functionally unrelated. ..
  24. Morris R, Bilyeu K, Laskey J, Cheikh N. Isolation of a gene encoding a glycosylated cytokinin oxidase from maize. Biochem Biophys Res Commun. 1999;255:328-33 pubmed
    ..The gene displays sequence homology with a putative oxidoreductase from Arabidopsis thaliana and with the fas5 gene from Rhodococcus fascians. ..
  25. Gallagher M, Burgess L, Brunden K. Characterization of multiple forms of the human glycine transporter type-2. Brain Res Mol Brain Res. 1999;70:101-15 pubmed
    ..Like rat GlyT2, the high-affinity uptake mediated by hGlyT2 was found to be insensitive to the GlyT1 inhibitor sarcosine. ..
  26. Gindullis F, Peffer N, Meier I. MAF1, a novel plant protein interacting with matrix attachment region binding protein MFP1, is located at the nuclear envelope. Plant Cell. 1999;11:1755-68 pubmed
    ..These data suggest that MFP1 and MAF1 are in vivo interaction partners and that both proteins are components of a nuclear substructure, previously undescribed in plants, that connects the nuclear envelope and the internal nuclear matrix...
  27. Seyfang A, Landfear S. Four conserved cytoplasmic sequence motifs are important for transport function of the Leishmania inositol/H(+) symporter. J Biol Chem. 2000;275:5687-93 pubmed
    ..We conclude that the conserved acidic residues Glu(187), Asp(300), and Glu(429) are critical for transport function of MIT. ..
  28. Born T, Smith D, Garka K, Renshaw B, Bertles J, Sims J. Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling. J Biol Chem. 2000;275:29946-54 pubmed
    ..The TIGIRR-1 and IL1RAPL cytoplasmic domains, however, were unable to signal as either IL-1R-like or AcP-like components, suggesting that they function as a new class of receptors within this family. ..
  29. McCauley D, Bronner Fraser M. Conservation of Pax gene expression in ectodermal placodes of the lamprey. Gene. 2002;287:129-39 pubmed
    ..These results suggest conservation of Pax genes and placodal structures in basal and derived vertebrates. ..
  30. van Leeuwen F, Gafken P, Gottschling D. Dot1p modulates silencing in yeast by methylation of the nucleosome core. Cell. 2002;109:745-56 pubmed
    ..Because Dot1p and histone H3 are conserved, similar mechanisms are likely at work in other eukaryotes. ..
  31. Boman A, Salo P, Hauglund M, Strand N, Rensink S, Zhdankina O. ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization. Mol Biol Cell. 2002;13:3078-95 pubmed
    ..Whereas mammalian GGAs must interact with ARF to localize to and function at the Golgi, interaction between yeast Ggas and Arf plays a minor role in Gga localization and function. ..
  32. Karpova O, Kuzmin E, Elthon T, Newton K. Differential expression of alternative oxidase genes in maize mitochondrial mutants. Plant Cell. 2002;14:3271-84 pubmed
    ..Significant expression of aox1 is detected only in NCS and CMS tassels. The induction pattern of maize aox genes could serve as a selective marker for diverse mitochondrial defects. ..
  33. Fei Y, Inoue K, Ganapathy V. Structural and functional characteristics of two sodium-coupled dicarboxylate transporters (ceNaDC1 and ceNaDC2) from Caenorhabditis elegans and their relevance to life span. J Biol Chem. 2003;278:6136-44 pubmed
    ..elegans may lead to decreased availability of dicarboxylates for cellular production of metabolic energy, thus creating a biological state similar to that of caloric restriction, and consequently leading to life span extension. ..
  34. Schomburg F, Bizzell C, Lee D, Zeevaart J, Amasino R. Overexpression of a novel class of gibberellin 2-oxidases decreases gibberellin levels and creates dwarf plants. Plant Cell. 2003;15:151-63 pubmed
  35. Federici B, Bigot Y. Origin and evolution of polydnaviruses by symbiogenesis of insect DNA viruses in endoparasitic wasps. J Insect Physiol. 2003;49:419-32 pubmed
  36. Nguyen K, Hu X, Colton C, Chakrabarti R, Zhu M, Pei D. Characterization of a human peptide deformylase: implications for antibacterial drug design. Biochemistry. 2003;42:9952-8 pubmed
    ..These results suggest that HsPDF is likely an evolutional remnant without any functional role in protein formylation/deformylation and validates PDF as an excellent target for antibacterial drug design. ..
  37. Osman A, Niles E, LoVerde P. Expression of functional Schistosoma mansoni Smad4: role in Erk-mediated transforming growth factor beta (TGF-beta) down-regulation. J Biol Chem. 2004;279:6474-86 pubmed
    ..SmSmad4 was shown to complement a human Smad4 deficiency through the restoration of TGF-beta-responsiveness in MDA-MB-468 breast cancer cells. ..
  38. Park H, Park I, Kim E, Youn B, Fields K, Dunker A, et al. Comparing skeletal and cardiac calsequestrin structures and their calcium binding: a proposed mechanism for coupled calcium binding and protein polymerization. J Biol Chem. 2004;279:18026-33 pubmed
  39. Sambade M, Kane P. The yeast vacuolar proton-translocating ATPase contains a subunit homologous to the Manduca sexta and bovine e subunits that is essential for function. J Biol Chem. 2004;279:17361-5 pubmed
    ..Based on this evidence, we propose that Vma9p is a genuine subunit of the yeast V-ATPase and that e subunits may be a functionally essential part of all eukaryotic V-ATPases. ..
  40. Jiang H, Ma C, Lu Z, Kanost M. Beta-1,3-glucan recognition protein-2 (betaGRP-2)from Manduca sexta; an acute-phase protein that binds beta-1,3-glucan and lipoteichoic acid to aggregate fungi and bacteria and stimulate prophenoloxidase activation. Insect Biochem Mol Biol. 2004;34:89-100 pubmed
    ..sexta, these results indicate that a complex system of protein sensors is an integral component of the insect immune system and that different recognition molecules have overlapping binding specificity and functions. ..
  41. Gu Y, Lin Q, Childress C, Yang W. Identification of the region in Cdc42 that confers the binding specificity to activated Cdc42-associated kinase. J Biol Chem. 2004;279:30507-13 pubmed
    ..Thus, our studies have defined a specific ACK-binding region in Cdc42 and have provided a molecular basis for generating ACK binding-defective mutants of Cdc42 to delineate ACK-mediated signaling pathway. ..
  42. Cho H, Hamza A, Zhan C, Tai H. Key NAD+-binding residues in human 15-hydroxyprostaglandin dehydrogenase. Arch Biochem Biophys. 2005;433:447-53 pubmed
    ..These results suggest that Ile-17, Asn-91, and Val-186 are involved in the interaction with NAD(+) and contribute to the full catalytic activity of 15-PGDH. ..
  43. Chen Y, Gollnick P. Alanine scanning mutagenesis of anti-TRAP (AT) reveals residues involved in binding to TRAP. J Mol Biol. 2008;377:1529-43 pubmed publisher
    ..In vivo studies confirmed the importance of these residues on the top of AT in regulating TRAP mediated gene regulation...
  44. Horowitz Brown S, Zarnowski R, Sharpee W, Keller N. Morphological transitions governed by density dependence and lipoxygenase activity in Aspergillus flavus. Appl Environ Microbiol. 2008;74:5674-85 pubmed publisher
  45. Corcoran C, Montalbano J, Sun H, He Q, Huang Y, Sheikh M. Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains. J Biol Chem. 2009;284:21955-70 pubmed publisher
    ..It is therefore possible that Pirh2A and the novel Pirh2 isoforms identified in this study may also modulate p53 function by engaging MDM2. ..
  46. Chae K, Kieslich C, Morikis D, Kim S, Lord E. A gain-of-function mutation of Arabidopsis lipid transfer protein 5 disturbs pollen tube tip growth and fertilization. Plant Cell. 2009;21:3902-14 pubmed publisher
    ..Thus, Arabidopsis LTP5 plays a significant role in reproduction. ..
  47. Vijayakumar S, Salerno J. Molecular modeling of the 3-D structure of cytochrome P-450scc. Biochim Biophys Acta. 1992;1160:281-6 pubmed
    ..The most hydrophobic of these four external loops is proposed as a candidate for membrane attachment. ..
  48. Kim J, Delauney A, Verma D. Control of de novo purine biosynthesis genes in ureide-producing legumes: induction of glutamine phosphoribosylpyrophosphate amidotransferase gene and characterization of its cDNA from soybean and Vigna. Plant J. 1995;7:77-86 pubmed
  49. Boehlein S, Richards N, Schuster S. Glutamine-dependent nitrogen transfer in Escherichia coli asparagine synthetase B. Searching for the catalytic triad. J Biol Chem. 1994;269:7450-7 pubmed
    ..abstract truncated at 400 words) ..
  50. Ferguson B, Brockdorff N, Formstone E, Ngyuen T, Kronmiller J, Zonana J. Cloning of Tabby, the murine homolog of the human EDA gene: evidence for a membrane-associated protein with a short collagenous domain. Hum Mol Genet. 1997;6:1589-94 pubmed
    ..The predicted extracellular collagenous domain of this membrane protein may play a key role in epithelial-mesenchymal interactions, defects of which are thought to underlie the Ta/XLHED phenotype. ..
  51. Wyckoff E, Stoebner J, Reed K, Payne S. Cloning of a Vibrio cholerae vibriobactin gene cluster: identification of genes required for early steps in siderophore biosynthesis. J Bacteriol. 1997;179:7055-62 pubmed
    ..cholerae strain with a chromosomal mutation in vibA was constructed by marker exchange. This strain was unable to produce vibriobactin or DHBA, confirming that in V. cholerae VibA catalyzes an early step in vibriobactin biosynthesis...
  52. Liu Y, Ruoho A, Rao V, Hurley J. Catalytic mechanism of the adenylyl and guanylyl cyclases: modeling and mutational analysis. Proc Natl Acad Sci U S A. 1997;94:13414-9 pubmed
    ..The models predict that an Asp from one domain is a general base in the reaction, and that the transition state is stabilized by a conserved Asn-Arg pair on the other domain. ..
  53. Kemppainen R, Behrend E. Dexamethasone rapidly induces a novel ras superfamily member-related gene in AtT-20 cells. J Biol Chem. 1998;273:3129-31 pubmed
    ..The function of this gene is unknown; however, its wide distribution and rapid induction by Dex suggests the possibility of a role in glucocorticoid action in a variety of tissues. ..
  54. Czarnecka Verner E, Yuan C, Scharf K, Englich G, Gurley W. Plants contain a novel multi-member class of heat shock factors without transcriptional activator potential. Plant Mol Biol. 2000;43:459-71 pubmed
    ..Class A HSFs are primarily responsible for stress-inducible activation of heat shock genes whereas some of the inert class B HSFs may be specialized for repression, or down-regulation, of the heat shock response. ..
  55. Rothstein D, Spacciapoli P, Tran L, Xu T, Roberts F, Dalla Serra M, et al. Anticandida activity is retained in P-113, a 12-amino-acid fragment of histatin 5. Antimicrob Agents Chemother. 2001;45:1367-73 pubmed
    ..These results identify P-113 as a potential antimicrobial agent in the treatment of oral candidiasis. ..
  56. Kurepa J, Walker J, Smalle J, Gosink M, Davis S, Durham T, et al. The small ubiquitin-like modifier (SUMO) protein modification system in Arabidopsis. Accumulation of SUMO1 and -2 conjugates is increased by stress. J Biol Chem. 2003;278:6862-72 pubmed
  57. Lu B, Liu T, Crosby J, Thomas Wohlever J, Lee I, Suzuki C. The ATP-dependent Lon protease of Mus musculus is a DNA-binding protein that is functionally conserved between yeast and mammals. Gene. 2003;306:45-55 pubmed
    ..In addition, the evolutionary conservation of mitochondrial Lon function is demonstrated by the ability of mouse Lon to substitute for the yeast protein in vivo. ..
  58. Valles S, Perera O, Strong C. Purification, biochemical characterization, and cDNA cloning of a glutathione S-transferase from the red imported fire ant, Solenopsis invicta. Insect Biochem Mol Biol. 2003;33:981-8 pubmed
    ..Comparison of the deduced amino acid sequence with GSTs from other species revealed that the enzyme was most closely related to sigma class GSTs. ..
  59. Gu W, Jackman J, Lohan A, Gray M, Phizicky E. tRNAHis maturation: an essential yeast protein catalyzes addition of a guanine nucleotide to the 5' end of tRNAHis. Genes Dev. 2003;17:2889-901 pubmed
    ..Surprisingly, despite its varied activities, Thg1p contains no recognizable catalytic or functional domains. ..
  60. McPherson C, Eipper B, Mains R. Multiple novel isoforms of Trio are expressed in the developing rat brain. Gene. 2005;347:125-35 pubmed
    ..Trio/duet is expressed in adult cortex and cerebellum. In the rat brain, each of these Trio isoforms is expressed at a higher level than full length Trio. ..
  61. Hogenkamp D, Arakane Y, Zimoch L, Merzendorfer H, Kramer K, Beeman R, et al. Chitin synthase genes in Manduca sexta: characterization of a gut-specific transcript and differential tissue expression of alternately spliced mRNAs during development. Insect Biochem Mol Biol. 2005;35:529-40 pubmed
  62. Weasner B, Salzer C, Kumar J. Sine oculis, a member of the SIX family of transcription factors, directs eye formation. Dev Biol. 2007;303:756-71 pubmed
    ..Taken together, these results shed new light on the role that so plays in eye specification. ..
  63. Smith S, McCann R. A C-terminal dimerization motif is required for focal adhesion targeting of Talin1 and the interaction of the Talin1 I/LWEQ module with F-actin. Biochemistry. 2007;46:10886-98 pubmed
  64. Backiel J, Juárez O, Zagorevski D, Wang Z, Nilges M, Barquera B. Covalent binding of flavins to RnfG and RnfD in the Rnf complex from Vibrio cholerae. Biochemistry. 2008;47:11273-84 pubmed publisher
    ..In contrast, in NqrC and NqrB the flavins are located in a cytoplasmic loop. This topological analysis suggests that there may be mechanistic differences between the Rnf and Na+-NQR complexes. ..
  65. Chen B, Liu P, Wang S, Ge Q, Zhan H, Mohler W, et al. ?-Catulin CTN-1 is required for BK channel subcellular localization in C. elegans body-wall muscle cells. EMBO J. 2010;29:3184-95 pubmed publisher
    ..These results suggest that CTN-1 plays an important role in BK channel function by mediating channel subcellular localization. ..
  66. Loijens J, Boronenkov I, Parker G, Anderson R. The phosphatidylinositol 4-phosphate 5-kinase family. Adv Enzyme Regul. 1996;36:115-40 pubmed
    ..The concept of localized complexes containing particular PIP5K isoforms that control the composition of different polyphosphoinositide pools will likely be important as the family of PIP5K isoforms grows. ..
  67. Chen C, Wieland T, Simon M. RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling. Proc Natl Acad Sci U S A. 1996;93:12885-9 pubmed
    ..This specific interaction further rationalizes the kinetics of the phototransduction cascade and provides a general hypothesis to explain the mechanism of interaction of RGS proteins with other G proteins. ..
  68. Cvitkovitch D, Gutierrez J, Bleiweis A. Role of the citrate pathway in glutamate biosynthesis by Streptococcus mutans. J Bacteriol. 1997;179:650-5 pubmed
    ..Indeed, S. mutans JH1005 was shown to assimilate ammonia as a sole source of nitrogen in minimal medium devoid of organic nitrogen sources. ..
  69. Yang Z, Yu C. Organizations and gene duplications of the human and mouse MHC complement gene clusters. Exp Clin Immunogenet. 2000;17:1-17 pubmed
    ..The modular duplications of human and mouse RP-C4-CYP21-TNX (RCCX) are sharply different as SKI2W2 is absent in the human MCGC, and TNXA and RP2 are smaller in size but higher in sequence conservation in humans. ..
  70. Wu L. ZAS: C2H2 zinc finger proteins involved in growth and development. Gene Expr. 2002;10:137-52 pubmed
    ..The ZAS, endothelin, and transcription factor AP2 genes form several linkage groups. Knowledge of the chromosomal locations of these genes provides valuable clues to the evolution of the vertebrate genome. ..
  71. Edwards S, Li C, Levy D, Brown J, Snow P, Campbell J. Saccharomyces cerevisiae DNA polymerase epsilon and polymerase sigma interact physically and functionally, suggesting a role for polymerase epsilon in sister chromatid cohesion. Mol Cell Biol. 2003;23:2733-48 pubmed
    ..We also show that trf5 Delta mutants, like trf4 Delta mutants, are defective in DNA repair and sister chromatid cohesion. ..
  72. Yano J, Rachochy V, Van Houten J. Glycosyl phosphatidylinositol-anchored proteins in chemosensory signaling: antisense manipulation of Paramecium tetraurelia PIG-A gene expression. Eukaryot Cell. 2003;2:1211-9 pubmed
    ..They also show specific defects in chemoresponse to glutamate and folate. Other cellular functions, such as growth and mating, seem to be normal...
  73. Pessi G, Kociubinski G, Mamoun C. A pathway for phosphatidylcholine biosynthesis in Plasmodium falciparum involving phosphoethanolamine methylation. Proc Natl Acad Sci U S A. 2004;101:6206-11 pubmed
    ..We show that miltefosine can also inhibit parasite proliferation within human erythrocytes. The importance of this enzyme in P. falciparum membrane biogenesis makes it a potential target for malaria chemotherapy. ..
  74. Jansen R, Wojciechowski M, Sanniyasi E, Lee S, Daniell H. Complete plastid genome sequence of the chickpea (Cicer arietinum) and the phylogenetic distribution of rps12 and clpP intron losses among legumes (Leguminosae). Mol Phylogenet Evol. 2008;48:1204-17 pubmed publisher
    ..The availability of the complete chickpea plastid genome sequence also provides valuable information on intergenic spacer regions among legumes and endogenous regulatory sequences for plastid genetic engineering...
  75. Burns L, Adams C, Riley S, Jutras B, Bowman A, Chenail A, et al. BpaB, a novel protein encoded by the Lyme disease spirochete's cp32 prophages, binds to erp Operator 2 DNA. Nucleic Acids Res. 2010;38:5443-55 pubmed publisher
    ..BpaB competed for binding to erp Operator 2 with a second B. burgdorferi DNA-binding protein, EbfC. Thus, cellular levels of free BpaB and EbfC could potentially control erp transcription levels...
  76. Takahara K, Lyons G, Greenspan D. Bone morphogenetic protein-1 and a mammalian tolloid homologue (mTld) are encoded by alternatively spliced transcripts which are differentially expressed in some tissues. J Biol Chem. 1994;269:32572-8 pubmed
    ..In situ hybridizations found punctate signals for all three forms localized to trophoblast giant cells in 17.5-day mouse placenta, with highest levels of expression, especially for BMP-1, near the maternal interface. ..
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