Experts and Doctors on amino acid oxidoreductases in United States


Locale: United States
Topic: amino acid oxidoreductases

Top Publications

  1. Hirai T, Visneski M, Kearns K, Zelis R, Musch T. Effects of NO synthase inhibition on the muscular blood flow response to treadmill exercise in rats. J Appl Physiol (1985). 1994;77:1288-93 pubmed
    ..1 (%SO + %FOG) + 16.4; r = 0.88, P < 0.001]. These results suggest that NO-mediated vasodilation contributes to the BF responses within and among the muscles of the rat's hindquarters during exercise. ..
  2. Bochkov Y, Hanson K, Keles S, Brockman Schneider R, Jarjour N, Gern J. Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma. Mucosal Immunol. 2010;3:69-80 pubmed publisher
    ..These findings suggest that differences in RV-induced gene expression profiles of cells from normal and mild asthmatic subjects could affect the acute inflammatory response to RV, and subsequent airway repair and remodeling. ..
  3. Liu C, Zhu P, Wang W, Li W, Shu Q, Chen Z, et al. Inhibition of lysyl oxidase by prostaglandin E2 via EP2/EP4 receptors in human amnion fibroblasts: Implications for parturition. Mol Cell Endocrinol. 2016;424:118-27 pubmed publisher
  4. Collard F, Zhang J, Nemet I, Qanungo K, Monnier V, Yee V. Crystal structure of the deglycating enzyme fructosamine oxidase (amadoriase II). J Biol Chem. 2008;283:27007-16 pubmed publisher
    ..In contrast, modification of other active site residues or of amino acids in the flexible active site loops has little effect, highlighting these regions as potential targets in designing an enzyme that will accept larger substrates. ..
  5. Liu G, Daneshgari F, Li M, Lin D, Lee U, Li T, et al. Bladder and urethral function in pelvic organ prolapsed lysyl oxidase like-1 knockout mice. BJU Int. 2007;100:414-8 pubmed
    ..Loxl1 (-/-) knockout mice can be used as an animal model for pelvic floor disorders. Further studies are needed to characterize the morphological and molecular alterations of the bladder and urethra. ..
  6. Lewis D, Rud K, Miller V. Cofactors of constitutive nitric oxide synthase and endothelium-dependent relaxations in canine femoral veins. J Cardiovasc Pharmacol. 1993;22:443-8 pubmed
    ..These data suggest that endothelium-dependent relaxations in canine femoral veins are mediated by factor(s) that are partly dependent on calmodulin or NADPH as cofactors for their production or release...
  7. Moon H, Finney J, Xu L, Moore D, Welch D, Mure M. MCF-7 cells expressing nuclear associated lysyl oxidase-like 2 (LOXL2) exhibit an epithelial-to-mesenchymal transition (EMT) phenotype and are highly invasive in vitro. J Biol Chem. 2013;288:30000-8 pubmed publisher
  8. Xu L, Go E, Finney J, Moon H, Lantz M, Rebecchi K, et al. Post-translational modifications of recombinant human lysyl oxidase-like 2 (rhLOXL2) secreted from Drosophila S2 cells. J Biol Chem. 2013;288:5357-63 pubmed publisher
    ..The catalytic domain of hLOX was not secreted from S2 cells using the same expression system. These results suggest that the N-glycan at Asn-644 of hLOXL2 enhances the solubility and stability of the LOX catalytic domain. ..
  9. Wood H, Lee U, Vurbic D, Sabanegh E, Ross J, Li T, et al. Sexual development and fertility of Loxl1-/- male mice. J Androl. 2009;30:452-9 pubmed publisher
    ..Although further studies are warranted, these findings suggest a subtle and likely multifactorial role of the LOXL1 protein in male sexual development and fertility. ..

More Information


  1. Aragon Martin J, Ritch R, Liebmann J, O Brien C, Blaaow K, Mercieca F, et al. Evaluation of LOXL1 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma. Mol Vis. 2008;14:533-41 pubmed
    ..To evaluate genetic susceptibility of lysyl oxidase-like 1 (LOXL1) gene polymorphisms to exfoliation syndrome (XFS) and exfoliation glaucoma (XFG) in a case-control cohort of American and European patients...
  2. Embury J, Charron C, Martynyuk A, Zori A, Liu B, Ali S, et al. PKU is a reversible neurodegenerative process within the nigrostriatum that begins as early as 4 weeks of age in Pah(enu2) mice. Brain Res. 2007;1127:136-50 pubmed
  3. Dong Y, Demaria S, Sun X, Santori F, Jesdale B, De Groot A, et al. HLA-A2-restricted CD8+-cytotoxic-T-cell responses to novel epitopes in Mycobacterium tuberculosis superoxide dismutase, alanine dehydrogenase, and glutamine synthetase. Infect Immun. 2004;72:2412-5 pubmed
    ..We report the identification of three novel HLA-A*0201-restricted CTL epitopes within mycobacterial superoxide dismutase (SodA), L-alanine dehydrogenase (AlaDH), and L-glutamine synthetase (GlnS) proteins. ..
  4. Huang J, Roby K, Pace J, Russell S, Hunt J. Cellular localization and hormonal regulation of inducible nitric oxide synthase in cycling mouse uterus. J Leukoc Biol. 1995;57:27-35 pubmed
    ..The data are consistent with the postulate that NO derived from uterine leukocytes and other types of cells plays a role in uterine cyclicity and preparation for pregnancy. ..
  5. Mohaupt M, Elzie J, Ahn K, Clapp W, Wilcox C, Kone B. Differential expression and induction of mRNAs encoding two inducible nitric oxide synthases in rat kidney. Kidney Int. 1994;46:653-65 pubmed
    ..We conclude that two iNOS isoforms are constitutively and heterogeneously expressed in the normal rat kidney, and that endotoxemia and cytokines differentially induce their expression. ..
  6. Navarrete R, Vara J, Hutchinson C. Purification of an inducible L-valine dehydrogenase of Streptomyces coelicolor A3(2). J Gen Microbiol. 1990;136:273-81 pubmed
    ..The time required for full induction was about 24 h and the level of induction was 2- to 23-fold. ..
  7. Núñez Palenius H, Cantliffe D, Huber D, Ciardi J, Klee H. Transformation of a muskmelon 'Galia' hybrid parental line (Cucumis melo L. var. reticulatus Ser.) with an antisense ACC oxidase gene. Plant Cell Rep. 2006;25:198-205 pubmed
    ..These transgenic muskmelon male parental lines have potential for use in the production of 'Galia' F1 hybrids with improved shelf life...
  8. Gallie D, Young T. The ethylene biosynthetic and perception machinery is differentially expressed during endosperm and embryo development in maize. Mol Genet Genomics. 2004;271:267-81 pubmed publisher
  9. Kim C, Liu Y, Thorne E, Yang H, Fukushige H, Gassmann W, et al. Activation of a stress-responsive mitogen-activated protein kinase cascade induces the biosynthesis of ethylene in plants. Plant Cell. 2003;15:2707-18 pubmed
    ..These results suggest that the induction of ethylene but not JA/MJ is involved in plant defense responses mediated by the NtMEK2-SIPK/WIPK pathway. ..
  10. Lee U, Gustilo Ashby A, Daneshgari F, Kuang M, Vurbic D, Lin D, et al. Lower urogenital tract anatomical and functional phenotype in lysyl oxidase like-1 knockout mice resembles female pelvic floor dysfunction in humans. Am J Physiol Renal Physiol. 2008;295:F545-55 pubmed publisher
    ..The increase in elastin clusters in the urethra of LOXL1-KO mice with POP suggests that elastin disorganization may lead to functional abnormalities. We conclude that LOXL1 warrants further investigation in the pathphysiology of FPFD. ..
  11. Tang L, Hutchinson C. Sequence, transcriptional, and functional analyses of the valine (branched-chain amino acid) dehydrogenase gene of Streptomyces coelicolor. J Bacteriol. 1993;175:4176-85 pubmed
    ..2% L-valine to the medium provokes approximately 32 and 80% increases in actinorhodin production in vdh+ and vdh strains, respectively. ..
  12. Mehta J, Lopez L, Chen L, Cox O. Alterations in nitric oxide synthase activity, superoxide anion generation, and platelet aggregation in systemic hypertension, and effects of celiprolol. Am J Cardiol. 1994;74:901-5 pubmed
    ..02), while heart rate was unchanged (73 +/- 11 vs 69 +/- 10 beats/min). Epinphrine and adenosine diphosphate-induced platelet aggregation was also increased in hypertensive subjects.(ABSTRACT TRUNCATED AT 250 WORDS)..
  13. Fujihara M, Ito N, Pace J, Watanabe Y, Russell S, Suzuki T. Role of endogenous interferon-beta in lipopolysaccharide-triggered activation of the inducible nitric-oxide synthase gene in a mouse macrophage cell line, J774. J Biol Chem. 1994;269:12773-8 pubmed
    ..These data thus suggest that endogenous IFN-beta, but not TNF-alpha, produced by LPS-stimulated J774 cells specifically contributes, probably in an auto/paracrine fashion, to the activation of the i-NOS gene expression by LPS. ..
  14. Aung T, Ozaki M, Lee M, Schlötzer Schrehardt U, Thorleifsson G, Mizoguchi T, et al. Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci. Nat Genet. 2017;49:993-1004 pubmed publisher
    ..3 (TMEM136), 6p21 (AGPAT1), 3p24 (RBMS3) and 5q23 (near SEMA6A). These findings provide biological insights into the pathology of XFS and highlight a potential role for naturally occurring rare LOXL1 variants in disease biology. ..
  15. Zheng J, Yang T, Zhou J, Xu M, Zhang X, Rao Z, et al. Efficient production of d-amino acid oxidase in Escherichia coli by a trade-off between its expression and biomass using N-terminal modification. Bioresour Technol. 2017;243:716-723 pubmed publisher
    ..Finally, the N-terminus disordered region of RtDAAO (HSQK) was replaced with HHHG and the variant enzyme activity reached 80.7U/mL (with a 40 percent of inactive DAAO reduced) in a 7.5L fermenter in 24h. ..
  16. Maccarana M, Svensson R, Knutsson A, Giannopoulos A, Pelkonen M, Weis M, et al. Asporin-deficient mice have tougher skin and altered skin glycosaminoglycan content and structure. PLoS ONE. 2017;12:e0184028 pubmed publisher
    ..Also, decorin and biglycan were doubled in Aspn-/- skin. Overall, asporin deficiency changes skin glycosaminoglycan composition, and decorin and biglycan content, which may explain the changes in skin mechanical properties. ..
  17. Sun D, Setlow P. Cloning, nucleotide sequence, and regulation of the Bacillus subtilis nadB gene and a nifS-like gene, both of which are essential for NAD biosynthesis. J Bacteriol. 1993;175:1423-32 pubmed
    ..However, nadB transcription and nadB-lacZ expression were decreased, at most, only slightly by a deletion in nifS. The possible role of the nifS gene product in NAD biosynthesis is discussed. ..
  18. Jamai A, Salome P, Schilling S, Weber A, McClung C. Arabidopsis photorespiratory serine hydroxymethyltransferase activity requires the mitochondrial accumulation of ferredoxin-dependent glutamate synthase. Plant Cell. 2009;21:595-606 pubmed publisher
    ..The requirement of protein-protein interactions and complex formation for photorespiratory SHMT activity demonstrates more complicated regulation of this crucial high flux pathway than anticipated. ..