Experts and Doctors on amino acid motifs in United States


Locale: United States
Topic: amino acid motifs

Top Publications

  1. Drachman J, Miyakawa Y, Luthi J, Dahlen D, Raney A, Geddis A, et al. Studies with chimeric Mpl/JAK2 receptors indicate that both JAK2 and the membrane-proximal domain of Mpl are required for cellular proliferation. J Biol Chem. 2002;277:23544-53 pubmed
    ..Although the nature of the signal transduction pathway is not yet known, this second proliferative event is likely to regulate c-myc expression. ..
  2. Seta K, Sadoshima J. Phosphorylation of tyrosine 319 of the angiotensin II type 1 receptor mediates angiotensin II-induced trans-activation of the epidermal growth factor receptor. J Biol Chem. 2003;278:9019-26 pubmed
    ..In summary, Tyr-319 of the AT1 receptor is phosphorylated in response to Ang II and plays a key role in mediating Ang II-induced transactivation of EGFR and cell proliferation, possibly through its interaction with SHP-2 and EGFR. ..
  3. Martinez Gomez N, Robers M, Downs D. Mutational analysis of ThiH, a member of the radical S-adenosylmethionine (AdoMet) protein superfamily. J Biol Chem. 2004;279:40505-10 pubmed
    ..Increased levels of AdoMet also corrected the thiamine requirement of members of the latter class. Residues required for in vivo function were identified and are discussed in the context of structures available for AdoMet enzymes. ..
  4. Xie L, Yamamoto B, Haoudi A, Semmes O, Green P. PDZ binding motif of HTLV-1 Tax promotes virus-mediated T-cell proliferation in vitro and persistence in vivo. Blood. 2006;107:1980-8 pubmed
  5. Wang H, Grant J, Doede C, Sadayappan S, Robbins J, Walker J. PKC-betaII sensitizes cardiac myofilaments to Ca2+ by phosphorylating troponin I on threonine-144. J Mol Cell Cardiol. 2006;41:823-33 pubmed
  6. Neumann G, Geisbert T, Ebihara H, Geisbert J, Daddario DiCaprio K, Feldmann H, et al. Proteolytic processing of the Ebola virus glycoprotein is not critical for Ebola virus replication in nonhuman primates. J Virol. 2007;81:2995-8 pubmed publisher
    ..We conclude that glycoprotein cleavage by subtilisin-like endoproteases is not critical for Ebola virus infectivity and virulence in nonhuman primates...
  7. Sakato M, Sakakibara H, King S. Chlamydomonas outer arm dynein alters conformation in response to Ca2+. Mol Biol Cell. 2007;18:3620-34 pubmed
  8. Asim M, Hafeez B, Siddiqui I, Gerlach C, Patz M, Mukhtar H, et al. Ligand-dependent corepressor acts as a novel androgen receptor corepressor, inhibits prostate cancer growth, and is functionally inactivated by the Src protein kinase. J Biol Chem. 2011;286:37108-17 pubmed publisher
    ..Thus, our studies indicate a role of LCoR as an AR corepressor and a tumor suppressor. Further, the decreased expression or inactivation of LCoR is as an important step toward PCa carcinogenesis in vivo. ..
  9. Parnell S, Puri S, Wallace D, Calvet J. Protein phosphatase-1? interacts with and dephosphorylates polycystin-1. PLoS ONE. 2012;7:e36798 pubmed publisher
    ..The results suggest that polycystin-1 forms a holoenzyme complex with PP1? via a conserved PP1-binding motif within the polycystin-1 C-tail, and that PKA-phosphorylated polycystin-1 serves as a substrate for the holoenzyme. ..

More Information

Publications379 found, 100 shown here

  1. Jadwin J, Ogiue Ikeda M, Machida K. The application of modular protein domains in proteomics. FEBS Lett. 2012;586:2586-96 pubmed publisher
  2. Yang L, Li Y, Ding Y, Choi K, Kazim A, Zhang Y. Prolidase directly binds and activates epidermal growth factor receptor and stimulates downstream signaling. J Biol Chem. 2013;288:2365-75 pubmed publisher
    ..In conclusion, PEPD is a ligand of EGFR and presents a novel mechanism of EGFR activation. ..
  3. Sun M, Grigsby I, Gorelick R, Mansky L, Musier Forsyth K. Retrovirus-specific differences in matrix and nucleocapsid protein-nucleic acid interactions: implications for genomic RNA packaging. J Virol. 2014;88:1271-80 pubmed publisher
    ..Taken together, these results are consistent with a role for deltaretrovirus MA proteins in viral RNA packaging...
  4. Reddy K, Bialkowska K, Fox J. Dynamic modulation of cytoskeletal proteins linking integrins to signaling complexes in spreading cells. Role of skelemin in initial integrin-induced spreading. J Biol Chem. 2001;276:28300-8 pubmed
  5. Ge G, Zhang Y, Steiglitz B, Greenspan D. Mammalian tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains. J Biol Chem. 2006;281:10786-98 pubmed
  6. Holmes S, Scarpinato K, McCulloch S, Schaaper R, Kunkel T. Specialized mismatch repair function of Glu339 in the Phe-X-Glu motif of yeast Msh6. DNA Repair (Amst). 2007;6:293-303 pubmed
  7. Barry A, Blackburn N. A selenocysteine variant of the human copper chaperone for superoxide dismutase. A Se-XAS probe of cluster composition at the domain 3-domain 3 dimer interface. Biochemistry. 2008;47:4916-28 pubmed publisher
  8. Papp Wallace K, Taracila M, Gatta J, Ohuchi N, Bonomo R, Nukaga M. Insights into ?-lactamases from Burkholderia species, two phylogenetically related yet distinct resistance determinants. J Biol Chem. 2013;288:19090-102 pubmed publisher
    ..The structural and biochemical analyses of PenA and PenI provide key insights into the hydrolytic mechanisms of ?-lactamases, which can lead to the rational design of novel agents against these pathogens. ..
  9. Zhu C, Dyer M, Uchikawa M, Kondoh H, Lagutin O, Oliver G. Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors. Development. 2002;129:2835-49 pubmed
    ..These specific alterations were not seen when the mutated form of Six3 cDNA was used in similar experimental approaches, indicating that Six3 interaction with Groucho proteins plays an essential role in vertebrate eye development. ..
  10. Higgs H. Actin nucleation: cortactin caught in the act. Curr Biol. 2002;12:R593-5 pubmed
    ..A variety of activators stimulate Arp2/3 complex to nucleate branched actin filament structures. New results provide important biochemical and structural information for activation by the proteins cortactin and N-WASP. ..
  11. Thoden J, Holden H. Molecular structure of galactokinase. J Biol Chem. 2003;278:33305-11 pubmed publisher
    ..Most likely these residues play key roles in catalysis. The structure of galactokinase described here serves as a model for understanding the functional consequences of point mutations known to result in Type II galactosemia in humans...
  12. Presgraves D, Balagopalan L, Abmayr S, Orr H. Adaptive evolution drives divergence of a hybrid inviability gene between two species of Drosophila. Nature. 2003;423:715-9 pubmed publisher
    ..These results show that a lethal hybrid incompatibility has evolved as a by-product of adaptive protein evolution...
  13. Ding W, Kim S, Nair A, Michael B, Boris Lawrie K, Tripp A, et al. Human T-cell lymphotropic virus type 1 p12I enhances interleukin-2 production during T-cell activation. J Virol. 2003;77:11027-39 pubmed
    ..These results are the first to indicate that HTLV-1, an etiologic agent associated with lymphoproliferative diseases, uses a conserved accessory protein to induce T-cell activation, an antecedent to efficient viral infection. ..
  14. Hong M, Fuangthong M, Helmann J, Brennan R. Structure of an OhrR-ohrA operator complex reveals the DNA binding mechanism of the MarR family. Mol Cell. 2005;20:131-41 pubmed
    ..The structure of the OhrR-ohrA operator complex reveals the DNA binding mechanism of the entire MarR family and suggests a common inducer binding pocket. ..
  15. Erdeniz N, Dudley S, Gealy R, Jinks Robertson S, Liskay R. Novel PMS1 alleles preferentially affect the repair of primer strand loops during DNA replication. Mol Cell Biol. 2005;25:9221-31 pubmed
    ..In addition, the findings reinforce the current view that during mutation avoidance, MMR is associated with the replication apparatus. ..
  16. Umadevi N, Kumar S, Narayana N. Crystallization and preliminary X-ray diffraction studies of the WW4 domain of the Nedd4-2 ubiquitin-protein ligase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005;61:1084-6 pubmed
    ..43, c = 103.21 A. Analysis of the self-rotation function suggests the presence of four WW4 molecules in the asymmetric unit, with a high unit-cell solvent content of 74%. ..
  17. Sagermann M, Baase W, Matthews B. Sequential reorganization of beta-sheet topology by insertion of a single strand. Protein Sci. 2006;15:1085-92 pubmed
    ..Our results illustrate how sequence insertions can facilitate protein evolution through both local and nonlocal changes in structure. ..
  18. Mattison K, Wilbur J, So M, Brennan R. Structure of FitAB from Neisseria gonorrhoeae bound to DNA reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs. J Biol Chem. 2006;281:37942-51 pubmed publisher
    ..Interactions between two FitB molecules result in the formation of a tetramer of FitAB heterodimers, which binds to the 36-bp DNA fragment and provides an explanation for how FitB enhances the DNA binding affinity of FitA...
  19. Carroll K, Khadim F, Spadavecchia S, Palmeri D, Lukac D. Direct interactions of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50/Rta protein with the cellular protein octamer-1 and DNA are critical for specifying transactivation of a delayed-early promoter and stimulating viral reactivatio. J Virol. 2007;81:8451-67 pubmed
    ..We propose a model in which Rta transactivation of the promoter is specified by the combination of DNA binding and interactions with several cellular DNA binding proteins including Oct-1. ..
  20. Patel A, Dharmarajan V, Cosgrove M. Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide. J Biol Chem. 2008;283:32158-61 pubmed publisher
    ..These results are consistent with a model in which WDR5 recognizes Arg-3765 of MLL1, which is essential for the assembly and enzymatic activity of the MLL1 core complex. ..
  21. Suzuki Y, Yanagisawa M, Yagi H, Nakatani Y, Yu R. Involvement of beta1-integrin up-regulation in basic fibroblast growth factor- and epidermal growth factor-induced proliferation of mouse neuroepithelial cells. J Biol Chem. 2010;285:18443-51 pubmed publisher
    ..The mechanism underlying the proliferation through beta1-integrin would not be expected to be completely identical, however, for bFGF and EGF. ..
  22. Kiraly D, Stone K, Colangelo C, Abbott T, Wang Y, Mains R, et al. Identification of kalirin-7 as a potential post-synaptic density signaling hub. J Proteome Res. 2011;10:2828-41 pubmed publisher
    ..We postulate that the kinase convergence and divergence observed in Kal7 identify it as a key player in integration of the multiple inputs that regulate synaptic structure and function. ..
  23. Harrison M, Schmitt P, Pei Z, Schmitt A. Role of ubiquitin in parainfluenza virus 5 particle formation. J Virol. 2012;86:3474-85 pubmed publisher
    ..Collectively, these findings suggest that the monoubiquitination of the PIV5 M protein is important for proper virus assembly and for the budding of infectious particles...
  24. Kline C, Mayfield M, Blackburn N. HHM motif at the CuH-site of peptidylglycine monooxygenase is a pH-dependent conformational switch. Biochemistry. 2013;52:2586-96 pubmed publisher
    ..The data suggest a more general utility for the HHM motif as a copper- and pH-dependent conformational switch. ..
  25. Frazier S, Cohen B, Lester H. An engineered glutamate-gated chloride (GluCl) channel for sensitive, consistent neuronal silencing by ivermectin. J Biol Chem. 2013;288:21029-42 pubmed publisher
    ..This receptor, named "GluClv2.0," is an improved tool for IVM-induced silencing. ..
  26. Tortorella M, Pratta M, Liu R, Abbaszade I, Ross H, Burn T, et al. The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage. J Biol Chem. 2000;275:25791-7 pubmed
    ..3) Aggrecanase-1 was not effective in cleaving glycosaminoglycan-free aggrecan. Taken together, these data suggest that the TSP-1 motif of aggrecanase-1 is critical for substrate recognition and cleavage. ..
  27. Yamane K, Wu X, Chen J. A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival. Mol Cell Biol. 2002;22:555-66 pubmed
    ..Taken together, the data presented here suggest that, like its putative counterparts in yeast species, TopBP1 may be involved in DNA damage and replication checkpoint controls. ..
  28. Anderson M, Fair K, Amero S, Nelson S, Harte P, Diaz M. A new family of cyclophilins with an RNA recognition motif that interact with members of the trx/MLL protein family in Drosophila and human cells. Dev Genes Evol. 2002;212:107-13 pubmed
    ..Over expression of Dcyp33 in DrosophilaSL1 cells results in down-regulation of AbdominalB Hoxgene expression, mirroring the effect of human Cyp33 on the expression of human HOXgenes. ..
  29. Cope G, Suh G, Aravind L, Schwarz S, Zipursky S, Koonin E, et al. Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1. Science. 2002;298:608-11 pubmed
    ..We propose that JAMM isopeptidases play important roles in a variety of physiological pathways. ..
  30. Bao L, Kimzey A, Sauter G, Sowadski J, Lu K, Wang D. Prevalent overexpression of prolyl isomerase Pin1 in human cancers. Am J Pathol. 2004;164:1727-37 pubmed
  31. Lu S, Symersky J, Li S, Carson M, Chen L, Meehan E, et al. Structural genomics of Caenorhabditis elegans: crystal structure of the tropomodulin C-terminal domain. Proteins. 2004;56:384-6 pubmed
  32. Richards G. Structural and functional analyses of phosphoglucose isomerase from Vibrio vulnificus and its lysyl aminopeptidase activity. Biochim Biophys Acta. 2004;1702:89-102 pubmed
    ..Together, these data provide a framework to account for PGI's LysAP activity and further demonstrate the structural complexity and functional importance of this molecule. ..
  33. Novotny M, Datta S, Biswas R, Hamilton T. Functionally independent AU-rich sequence motifs regulate KC (CXCL1) mRNA. J Biol Chem. 2005;280:30166-74 pubmed
    ..Collectively, these findings document the presence of multiple independent determinants of KC mRNA function and demonstrate that these operate via distinct mechanisms. ..
  34. Feller A, Hernandez J, Grotewold E. An ACT-like domain participates in the dimerization of several plant basic-helix-loop-helix transcription factors. J Biol Chem. 2006;281:28964-74 pubmed publisher
    ..These findings underscore the function of R as a docking site for multiple protein-protein interactions and provide evidence for the presence of a novel dimerization domain in multiple plant bHLH proteins...
  35. Fisk J, Ammerman M, Presnyak V, Read L. TbRGG2, an essential RNA editing accessory factor in two Trypanosoma brucei life cycle stages. J Biol Chem. 2008;283:23016-25 pubmed publisher
    ..This is the first example of an RNA editing accessory factor that functions in the mammalian infective T. brucei life cycle stage. ..
  36. Nelsen S, Christian J. Site-specific cleavage of BMP4 by furin, PC6, and PC7. J Biol Chem. 2009;284:27157-66 pubmed publisher
    ..These results suggest that PC7, or a convertase with similar substrate specificity, functions to selectively cleave the S1 site of pro-BMP4 in a developmentally regulated fashion. ..
  37. Ogino T, Yadav S, Banerjee A. Histidine-mediated RNA transfer to GDP for unique mRNA capping by vesicular stomatitis virus RNA polymerase. Proc Natl Acad Sci U S A. 2010;107:3463-8 pubmed publisher
  38. Fedarovich A, Nicholas R, Davies C. Unusual conformation of the SxN motif in the crystal structure of penicillin-binding protein A from Mycobacterium tuberculosis. J Mol Biol. 2010;398:54-65 pubmed publisher
    ..Finally, the structure shows that one of the two threonines postulated to be targets for phosphorylation is inaccessible (Thr362), whereas the other (Thr437) is well placed on a surface loop near the active site. ..
  39. Dewan V, Wei M, Kleiman L, Musier Forsyth K. Dual role for motif 1 residues of human lysyl-tRNA synthetase in dimerization and packaging into HIV-1. J Biol Chem. 2012;287:41955-62 pubmed publisher
    ..Taken together, these data suggest that H7 of LysRS has a dual function. In its canonical role it maintains the synthetase dimer interface, whereas in its function in tRNA primer recruitment, it bridges interactions with HIV-1 Gag. ..
  40. Busman Sahay K, Drake L, Sitaram A, Marks M, Drake J. Cis and trans regulatory mechanisms control AP2-mediated B cell receptor endocytosis via select tyrosine-based motifs. PLoS ONE. 2013;8:e54938 pubmed publisher
  41. Sheppard N, Glover C, Terns R, Terns M. The CRISPR-associated Csx1 protein of Pyrococcus furiosus is an adenosine-specific endoribonuclease. RNA. 2016;22:216-24 pubmed publisher
    ..Collectively, the findings indicate that invader silencing by Type III-B CRISPR-Cas systems relies both on RNA and DNA nuclease activities from the Cmr effector complex as well as on the affiliated, trans-acting Csx1 endoribonuclease. ..
  42. Chaliotis A, Vlastaridis P, Mossialos D, Ibba M, Becker H, Stathopoulos C, et al. The complex evolutionary history of aminoacyl-tRNA synthetases. Nucleic Acids Res. 2017;45:1059-1068 pubmed publisher
    ..These tools also may help to identify organisms with alternative pathways that are involved in maintaining the fidelity of the genetic code. ..
  43. Haeseleer F, Palczewski K. Calmodulin and Ca2+-binding proteins (CaBPs): variations on a theme. Adv Exp Med Biol. 2002;514:303-17 pubmed
    ..CaBPs could be cell-type specific proteins that play a key role in the Ca2+ signaling of specialized retinal neurons. ..
  44. Lutkenhaus J, Sundaramoorthy M. MinD and role of the deviant Walker A motif, dimerization and membrane binding in oscillation. Mol Microbiol. 2003;48:295-303 pubmed
    ..The sequential interaction of MinD with these two proteins, which is dictated by the membrane, is critical to the oscillatory mechanism involved in spatial regulation of division...
  45. Tang W, Perry S. Binding site selection for the plant MADS domain protein AGL15: an in vitro and in vivo study. J Biol Chem. 2003;278:28154-9 pubmed
    ..One gene, DTA4 (for Downstream Target of AGL15-4), was identified by this method, and then confirmed as a direct target of AGL15 in vivo. ..
  46. Dhawan P, Peng X, Sutton A, MacDonald P, Croniger C, Trautwein C, et al. Functional cooperation between CCAAT/enhancer-binding proteins and the vitamin D receptor in regulation of 25-hydroxyvitamin D3 24-hydroxylase. Mol Cell Biol. 2005;25:472-87 pubmed
    ..These findings also indicate a novel role for C/EBPbeta in the cross talk between PTH and 1,25(OH)(2)D(3) that involves the regulation of VDR transcription. ..
  47. Betti C, Villalobos M, Jiang Q, Cline E, Diaz M, Loredo G, et al. Cleavage of the MLL gene by activators of apoptosis is independent of topoisomerase II activity. Leukemia. 2005;19:2289-95 pubmed
    ..Inactivation of topoisomerase II by the catalytic inhibitor merbarone did not inhibit MLL cleavage, suggesting that the initial cleavage step for MLL rearrangement is not mediated by topoisomerase II. ..
  48. Franke J, Batts W, Ahne W, Kurath G, Winton J. Sequence motifs and prokaryotic expression of the reptilian paramyxovirus fusion protein. Arch Virol. 2006;151:449-64 pubmed
  49. Janovick J, Knollman P, Brothers S, Ayala Yáñez R, Aziz A, Conn P. Regulation of G protein-coupled receptor trafficking by inefficient plasma membrane expression: molecular basis of an evolved strategy. J Biol Chem. 2006;281:8417-25 pubmed
  50. Gui L, Wojciechowski K, Gildner C, Nedelkovska H, Hocking D. Identification of the heparin-binding determinants within fibronectin repeat III1: role in cell spreading and growth. J Biol Chem. 2006;281:34816-25 pubmed
  51. Nagy M, Wu H, Liu Z, Kedzierska Mieszkowska S, Zolkiewski M. Walker-A threonine couples nucleotide occupancy with the chaperone activity of the AAA+ ATPase ClpB. Protein Sci. 2009;18:287-93 pubmed publisher
    ..We postulate that AAA+ ATPases with the noncanonical Walker A might utilize distinct mechanisms to couple the ATPase cycle with their substrate-remodeling activity. ..
  52. Shell S, Li Z, Shkriabai N, Kvaratskhelia M, Brosey C, Serrano M, et al. Checkpoint kinase ATR promotes nucleotide excision repair of UV-induced DNA damage via physical interaction with xeroderma pigmentosum group A. J Biol Chem. 2009;284:24213-22 pubmed publisher
    ..Taken together, our results suggest that the ATR-XPA interaction mediated by the helix-turn-helix motif of XPA plays an important role in DNA-damage responses to promote cell survival and genomic stability after UV irradiation. ..
  53. Beagle B, Mi K, Johnson G. Phosphorylation of PPP(S/T)P motif of the free LRP6 intracellular domain is not required to activate the Wnt/beta-catenin pathway and attenuate GSK3beta activity. J Cell Biochem. 2009;108:886-95 pubmed publisher
  54. Jacob Y, Stroud H, Leblanc C, Feng S, Zhuo L, Caro E, et al. Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases. Nature. 2010;466:987-91 pubmed publisher
    ..Mutation of ATXR5 and ATXR6 also causes upregulation of transposon expression and has pleiotropic effects on plant development. These results uncover a novel pathway that prevents over-replication of heterochromatin in Arabidopsis. ..
  55. Mayers J, Fyfe I, Schuh A, Chapman E, Edwardson J, Audhya A. ESCRT-0 assembles as a heterotetrameric complex on membranes and binds multiple ubiquitinylated cargoes simultaneously. J Biol Chem. 2011;286:9636-45 pubmed publisher
    ..Based on these data, we present a revised model for ESCRT-0 function in cargo recruitment and concentration at the endosome. ..
  56. Schorzman A, Perera L, Cutalo Patterson J, Pedersen L, Pedersen L, Kunkel T, et al. Modeling of the DNA-binding site of yeast Pms1 by mass spectrometry. DNA Repair (Amst). 2011;10:454-65 pubmed publisher
    ..The proposed model defines the DNA-binding interface along a positively charged groove of the Pms1-NTD and complements prior mutagenesis studies of Escherichia coli and eukaryotic MutL. ..
  57. Martin Tumasz S, Richie A, Clos L, Brow D, Butcher S. A novel occluded RNA recognition motif in Prp24 unwinds the U6 RNA internal stem loop. Nucleic Acids Res. 2011;39:7837-47 pubmed publisher
    ..We propose a mechanistic and structural model of Prp24's annealing activity in which oRRM4 functions to destabilize the U6 ISL during U4/U6 assembly. ..
  58. Chartron J, VanderVelde D, Rao M, Clemons W. Get5 carboxyl-terminal domain is a novel dimerization motif that tethers an extended Get4/Get5 complex. J Biol Chem. 2012;287:8310-7 pubmed publisher
    ..Using solution x-ray scattering and the structures of all folded domains, we present a model of the full-length Get4/Get5 complex. ..
  59. Codding J, Israel B, Thorpe C. Protein substrate discrimination in the quiescin sulfhydryl oxidase (QSOX) family. Biochemistry. 2012;51:4226-35 pubmed publisher
    ..These aspects of protein substrate discrimination by QSOX family members are rationalized in terms of the stringent steric requirements for disulfide exchange reactions. ..
  60. Dharmarajan V, Lee J, Patel A, Skalnik D, Cosgrove M. Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases. J Biol Chem. 2012;287:27275-89 pubmed publisher
    ..These results highlight a new class of methylation inhibitors that may be useful for the treatment of MLL1-related malignancies. ..
  61. Ahsan N, Huang Y, Tovar Mendez A, Swatek K, Zhang J, Miernyk J, et al. A versatile mass spectrometry-based method to both identify kinase client-relationships and characterize signaling network topology. J Proteome Res. 2013;12:937-48 pubmed publisher
    ..Structural modeling revealed that phosphorylation of AtPPI-2 induces conformational changes that modulate TOPP binding. ..
  62. Geetha T, Rege S, Mathews S, Meakin S, White M, Babu J. Nerve growth factor receptor TrkA, a new receptor in insulin signaling pathway in PC12 cells. J Biol Chem. 2013;288:23807-13 pubmed publisher
    ..Moreover, expression of TrkA kinase-inactive mutant blocked the activation of Akt and Erk5 in response to insulin or NGF. Based on these data, we propose that TrkA participates in insulin signaling pathway in PC12 cells. ..
  63. Casu F, Duggan B, Hennig M. The arginine-rich RNA-binding motif of HIV-1 Rev is intrinsically disordered and folds upon RRE binding. Biophys J. 2013;105:1004-17 pubmed publisher
    ..RRE recognition triggers a crucial coil-to-helix transition employing an induced-fit mechanism. ..
  64. Huang T, Kudo N, Yoshida M, Miyamoto S. A nuclear export signal in the N-terminal regulatory domain of IkappaBalpha controls cytoplasmic localization of inactive NF-kappaB/IkappaBalpha complexes. Proc Natl Acad Sci U S A. 2000;97:1014-9 pubmed
    ..Our findings indicate that the dominant nuclear export over nuclear import contributes to the largely cytoplasmic localization of the inactive complexes to achieve efficient NF-kappaB activation by extracellular signals. ..
  65. Brunkow M, Jeffery E, Hjerrild K, Paeper B, Clark L, Yasayko S, et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet. 2001;27:68-73 pubmed
    ..In sf mice, a frameshift mutation results in a product lacking the forkhead domain. Genetic complementation demonstrates that the protein product of Foxp3, scurfin, is essential for normal immune homeostasis. ..
  66. Panaviene Z, Baker J, Nagy P. The overlapping RNA-binding domains of p33 and p92 replicase proteins are essential for tombusvirus replication. Virology. 2003;308:191-205 pubmed
    ..Interestingly, mutations within the RPR motif of p33 and p92 had different effects on RNA replication, suggesting different roles for the RNA-binding motifs of these proteins in tombusvirus replication...
  67. Lu X, Zhai C, Gopalakrishnan V, Buchanan B. Automatic annotation of protein motif function with Gene Ontology terms. BMC Bioinformatics. 2004;5:122 pubmed
    ..Empirical result demonstrated that the methods have a great potential for detecting and augmenting information about the functions of newly discovered candidate protein motifs. ..
  68. Alpatov R, Munguba G, Caton P, Joo J, Shi Y, Shi Y, et al. Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene. Mol Cell Biol. 2004;24:10223-35 pubmed
    ..This interaction may reflect the existence of coupling factors involved in CtBP-mediated transcriptional regulation and mRNA processing events. ..
  69. Plummer L, Hildebrandt E, Porter S, Rogers V, McCracken J, Schmidt W. Mutational analysis of the ras converting enzyme reveals a requirement for glutamate and histidine residues. J Biol Chem. 2006;281:4596-605 pubmed
  70. Schiller M, Chakrabarti K, King G, Schiller N, Eipper B, Maciejewski M. Regulation of RhoGEF activity by intramolecular and intermolecular SH3 domain interactions. J Biol Chem. 2006;281:18774-86 pubmed
    ..This study establishes a novel molecular mechanism whereby intramolecular and intermolecular Kalirin SH3 domain/ligand interactions modulate GEF activity, a regulatory mechanism that is likely used by other RhoGEF family members. ..
  71. Mao L, Zheng W. Combining comparative genomics with de novo motif discovery to identify human transcription factor DNA-binding motifs. BMC Bioinformatics. 2006;7 Suppl 4:S21 pubmed
    ..The newly developed method can be used to extract regulatory signals in co-regulated genes, which can be derived from the microarray clustering analysis. ..
  72. Crouch E, Cox L, Morales K, Passarelli A. Inter-subunit interactions of the Autographa californica M nucleopolyhedrovirus RNA polymerase. Virology. 2007;367:265-74 pubmed
    ..Studies on protein-protein interactions may provide insight into the structural design of the complex and mechanistic aspects affecting late and very late gene expression. ..
  73. Faulhammer F, Kanjilal Kolar S, Knödler A, Lo J, Lee Y, Konrad G, et al. Growth control of Golgi phosphoinositides by reciprocal localization of sac1 lipid phosphatase and pik1 4-kinase. Traffic. 2007;8:1554-67 pubmed
    ..Sac1p and Pik1p/Frq1p are therefore elements of a unique machinery that synchronizes ER and Golgi function in response to different growth conditions. ..
  74. Nagaraj S, Rajendran A, Jackson C, Longtine M. Role of nucleotide binding in septin-septin interactions and septin localization in Saccharomyces cerevisiae. Mol Cell Biol. 2008;28:5120-37 pubmed publisher
    ..We find no evidence that nucleotide binding is specifically involved in the interaction of septins with septin-associated proteins. ..
  75. Wacker J, Feller D, Tang X, DeFino M, Namkung Y, Lyssand J, et al. Disease-causing mutation in GPR54 reveals the importance of the second intracellular loop for class A G-protein-coupled receptor function. J Biol Chem. 2008;283:31068-78 pubmed publisher
    ..Importantly, mutations that disrupt this key hydrophobic interface can manifest as human disease. ..
  76. Humbard M, Zhou G, Maupin Furlow J. The N-terminal penultimate residue of 20S proteasome alpha1 influences its N(alpha) acetylation and protein levels as well as growth rate and stress responses of Haloferax volcanii. J Bacteriol. 2009;191:3794-803 pubmed publisher
  77. Ham J, Majerczak D, Nomura K, Mecey C, Uribe F, He S, et al. Multiple activities of the plant pathogen type III effector proteins WtsE and AvrE require WxxxE motifs. Mol Plant Microbe Interact. 2009;22:703-12 pubmed publisher
  78. Zondlo S, Gao F, Zondlo N. Design of an encodable tyrosine kinase-inducible domain: detection of tyrosine kinase activity by terbium luminescence. J Am Chem Soc. 2010;132:5619-21 pubmed publisher
    ..These results indicate that tyrosine kinase-inducible domains may be used as sensors of tyrosine kinase and tyrosine phosphatase activity and in the detection of tyrosine kinase inhibitors...
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