Experts and Doctors on amino acid motifs in United Kingdom


Locale: United Kingdom
Topic: amino acid motifs

Top Publications

  1. Hickabottom M, Parker G, Freemont P, Crook T, Allday M. Two nonconsensus sites in the Epstein-Barr virus oncoprotein EBNA3A cooperate to bind the co-repressor carboxyl-terminal-binding protein (CtBP). J Biol Chem. 2002;277:47197-204 pubmed
  2. Bailly M. Ena/VASP family: new partners, bigger enigma. Dev Cell. 2004;7:462-3 pubmed
    ..Two new studies have uncovered a new family of proteins that can regulate actin dynamics both locally at the membrane interface and globally throughout the cell. ..
  3. Patterson H, Brannigan J, Cutting S, Wilson K, Wilkinson A, Ab E, et al. The structure of bypass of forespore C, an intercompartmental signaling factor during sporulation in Bacillus. J Biol Chem. 2005;280:36214-20 pubmed
    ..The sequence connecting the domains contains a conserved DISP motif to which mutations that affect BofC activity map. Possible roles for BofC in the sigma(K) checkpoint are discussed in the light of sequence and structure comparisons. ..
  4. Krachler A, Sharma A, Kleanthous C. Self-association of TPR domains: Lessons learned from a designed, consensus-based TPR oligomer. Proteins. 2010;78:2131-43 pubmed publisher
    ..Our study lays the foundations for understanding the structural basis for TPR domain self-association and how such self-association can be regulated in TPR domain-containing proteins. ..
  5. Yates L, Füzéry A, Bonet R, Campbell I, Gilbert R. Biophysical analysis of Kindlin-3 reveals an elongated conformation and maps integrin binding to the membrane-distal β-subunit NPXY motif. J Biol Chem. 2012;287:37715-31 pubmed publisher
    ..Overall these data support current biological, clinical, and mutational data on Kindlin-3/β-tail binding and provide novel insights into the overall conformation and interactions of Kindlin-3. ..
  6. Rickman C, Archer D, Meunier F, Craxton M, Fukuda M, Burgoyne R, et al. Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate. J Biol Chem. 2004;279:12574-9 pubmed
    ..Our results shed new light on the functional importance of the conserved polybasic synaptotagmin motif, suggesting that synaptotagmin interacts with the t-SNARE dimer to up-regulate the probability of SNARE-mediated membrane fusion. ..
  7. Eydmann T, Sommariva E, Inagawa T, Mian S, Klar A, Dalgaard J. Rtf1-mediated eukaryotic site-specific replication termination. Genetics. 2008;180:27-39 pubmed publisher
    ..Together our data establish that multiple protein DNA and protein-protein interactions between Rtf1 molecules and both the repeated motifs and the enhancer region of RTS1 are required for site-specific termination at the RTS1 element. ..
  8. Komander D, Patel M, Laurin M, Fradet N, Pelletier A, Barford D, et al. An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in Rac signaling. Mol Biol Cell. 2008;19:4837-51 pubmed publisher
    ..Significantly, although this does not affect DOCK180 GEF activity toward Rac in vivo, Rac signaling is impaired, implying additional roles for ELMO in mediating intracellular Rac signaling. ..
  9. Neyen C, Plüddemann A, Roversi P, Thomas B, Cai L, van der Westhuyzen D, et al. Macrophage scavenger receptor A mediates adhesion to apolipoproteins A-I and E. Biochemistry. 2009;48:11858-71 pubmed publisher

More Information

Publications122 found, 100 shown here

  1. Cevik V, Kidd B, Zhang P, Hill C, Kiddle S, Denby K, et al. MEDIATOR25 acts as an integrative hub for the regulation of jasmonate-responsive gene expression in Arabidopsis. Plant Physiol. 2012;160:541-55 pubmed publisher
    ..These results suggest an important role for MED25 as an integrative hub within the Mediator complex during the regulation of JA-associated gene expression. ..
  2. Conners R, Konarev A, Forsyth J, Lovegrove A, Marsh J, Joseph Horne T, et al. An unusual helix-turn-helix protease inhibitory motif in a novel trypsin inhibitor from seeds of Veronica (Veronica hederifolia L.). J Biol Chem. 2007;282:27760-8 pubmed
    ..The VhTI peptide shows that effective enzyme inhibitors can be constructed from simple helical motifs and provides a new scaffold on which to base the design of novel serine protease inhibitors...
  3. Basu S, Totty N, Irwin M, Sudol M, Downward J. Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis. Mol Cell. 2003;11:11-23 pubmed
    ..Akt phosphorylation of YAP may thus suppress the induction of the proapoptotic gene expression response following cellular damage. ..
  4. Reinicke A, Hutchinson J, Magee A, Mastroeni P, Trowsdale J, Kelly A. A Salmonella typhimurium effector protein SifA is modified by host cell prenylation and S-acylation machinery. J Biol Chem. 2005;280:14620-7 pubmed
    ..This is the only known example of a bacterial effector protein that is modified both by mammalian cell S-acylation and prenylation machinery. ..
  5. Guo C, Whitmarsh A. The beta-arrestin-2 scaffold protein promotes c-Jun N-terminal kinase-3 activation by binding to its nonconserved N terminus. J Biol Chem. 2008;283:15903-11 pubmed publisher
    ..These findings uncover molecular determinants of beta-arrestin-2 scaffold complex assembly and assign a previously unrecognized role for the unique extended N terminus of JNK3. ..
  6. Greaves J, Carmichael J, Chamberlain L. The palmitoyl transferase DHHC2 targets a dynamic membrane cycling pathway: regulation by a C-terminal domain. Mol Biol Cell. 2011;22:1887-95 pubmed publisher
    ..This study is the first to highlight dynamic cycling of a mammalian DHHC protein between clearly defined membrane compartments, and to identify domains that specify membrane targeting of this protein family. ..
  7. Newman E, Holmes R, Craig H, Klein K, Lingappa J, Malim M, et al. Antiviral function of APOBEC3G can be dissociated from cytidine deaminase activity. Curr Biol. 2005;15:166-70 pubmed
    ..Accordingly, we propose that APOBEC3G can achieve an anti-HIV-1 effect through an undescribed mechanism that is distinct from cytidine deamination. ..
  8. Liu H, Thaker Y, Stagg L, Schneider H, Ladbury J, Rudd C. SLP-76 sterile α motif (SAM) and individual H5 α helix mediate oligomer formation for microclusters and T-cell activation. J Biol Chem. 2013;288:29539-49 pubmed publisher
    ..Our data identified for the first time a role for the SAM domain in mediating SLP-76 self-association for T-cell function. ..
  9. Demonacos C, Krstic Demonacos M, La Thangue N. A TPR motif cofactor contributes to p300 activity in the p53 response. Mol Cell. 2001;8:71-84 pubmed
    ..Strap facilitates p53 activity in response to stress, in part through the stress-responsive accumulation of Strap protein and interfering with the MDM2-dependent downregulation of p53. ..
  10. Parsons M, Keppler M, Kline A, Messent A, Humphries M, Gilchrist R, et al. Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis. Mol Cell Biol. 2002;22:5897-911 pubmed
    ..Importantly, our findings outline a new concept as to how carcinoma cell chemotaxis is enhanced and provide a conceptual basis for interfering with tumor cell dissemination. ..
  11. Inagawa T, Yamada Inagawa T, Eydmann T, Mian I, WANG T, Dalgaard J. Schizosaccharomyces pombe Rtf2 mediates site-specific replication termination by inhibiting replication restart. Proc Natl Acad Sci U S A. 2009;106:7927-32 pubmed publisher
    ..Our results are consistent with a model in which Rtf2 stabilizes the replication fork stalled at RTS1 until completion of DNA synthesis by a converging replication fork initiated at a flanking origin. ..
  12. Gorleku O, Barns A, Prescott G, Greaves J, Chamberlain L. Endoplasmic reticulum localization of DHHC palmitoyltransferases mediated by lysine-based sorting signals. J Biol Chem. 2011;286:39573-84 pubmed publisher
    ..These results suggest that targeting of intrinsically active DHHC proteins to defined membrane compartments is an important factor contributing to spatially restricted patterns of substrate palmitoylation. ..
  13. Siniossoglou S, Hurt E, Pelham H. Psr1p/Psr2p, two plasma membrane phosphatases with an essential DXDX(T/V) motif required for sodium stress response in yeast. J Biol Chem. 2000;275:19352-60 pubmed
    ..Based on these data, we suggest that Psr1p/Psr2p, members of an emerging class of eukaryotic phosphatases, are novel regulators of salt stress response in yeast. ..
  14. Krugmann S, Jordens I, Gevaert K, Driessens M, Vandekerckhove J, Hall A. Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex. Curr Biol. 2001;11:1645-55 pubmed
    ..This IRSp53:Mena complex initiates actin filament assembly into filopodia. ..
  15. Bouche N, Scharlat A, Snedden W, Bouchez D, Fromm H. A novel family of calmodulin-binding transcription activators in multicellular organisms. J Biol Chem. 2002;277:21851-61 pubmed
    ..2 nm) in the presence of calcium. We suggest that CAMTAs comprise a conserved family of transcription factors in a wide range of multicellular eukaryotes, which possibly respond to calcium signaling by direct binding of calmodulin. ..
  16. Wang X, Li W, Parra J, Beugnet A, Proud C. The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation. Mol Cell Biol. 2003;23:1546-57 pubmed
    ..However, in 4E-BP3, replacement of the alanine at the position corresponding to S112 by serine or glutamate did not confer the ability to be released from eIF4E in response to insulin. ..
  17. Chaikuad A, Alfano I, Kerr G, Sanvitale C, Boergermann J, Triffitt J, et al. Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva. J Biol Chem. 2012;287:36990-8 pubmed publisher
    ..The presented ALK2 structure offers a valuable template for the further design of specific inhibitors of BMP signaling. ..
  18. Parmentier M, Woods D, Greig S, Phan P, Radovic A, Bryant P, et al. Rapsynoid/partner of inscuteable controls asymmetric division of larval neuroblasts in Drosophila. J Neurosci. 2000;20:RC84 pubmed
    ..Our data show that Raps is a novel protein involved in the control of asymmetric divisions of neuroblasts. ..
  19. Banfield M, Naylor R, Robertson A, Allen S, Dawbarn D, Brady R. Specificity in Trk receptor:neurotrophin interactions: the crystal structure of TrkB-d5 in complex with neurotrophin-4/5. Structure. 2001;9:1191-9 pubmed
    ..These features provide an explanation both for the limited crossreactivity observed between the range of neurotrophins and Trk receptors and for the high-affinity binding associated with respective ligand-receptor pairs. ..
  20. Teo H, Veprintsev D, Williams R. Structural insights into endosomal sorting complex required for transport (ESCRT-I) recognition of ubiquitinated proteins. J Biol Chem. 2004;279:28689-96 pubmed
    ..The structure provides a detailed framework for design of mutants that can specifically affect ESCRT-I-dependent sorting of ubiquitinated cargo without affecting Vps27-mediated delivery of cargo to endosomes. ..
  21. Swingler T, Bess K, Yao J, Stifani S, Jayaraman P. The proline-rich homeodomain protein recruits members of the Groucho/Transducin-like enhancer of split protein family to co-repress transcription in hematopoietic cells. J Biol Chem. 2004;279:34938-47 pubmed
    ..Finally, we show that a mutation in the PRH N-terminal domain that blocks the PRH-TLE1 interaction in vitro eliminates co-repression. We discuss these results in terms of the roles of PRH and TLE in cell differentiation and development. ..
  22. Golbang A, Murthy M, Hamad A, Liu C, Cope G, Van t Hoff W, et al. A new kindred with pseudohypoaldosteronism type II and a novel mutation (564D>H) in the acidic motif of the WNK4 gene. Hypertension. 2005;46:295-300 pubmed
  23. McCartney C, McClafferty H, Huibant J, Rowan E, Shipston M, Rowe I. A cysteine-rich motif confers hypoxia sensitivity to mammalian large conductance voltage- and Ca-activated K (BK) channel alpha-subunits. Proc Natl Acad Sci U S A. 2005;102:17870-6 pubmed
    ..Because STREX splice-variant expression is tissue-specific and dynamically controlled, alternative splicing of BK channels provides a mechanism to control the plasticity of cellular responses to hypoxia. ..
  24. Weissman K, Hong H, Popovic B, Meersman F. Evidence for a protein-protein interaction motif on an acyl carrier protein domain from a modular polyketide synthase. Chem Biol. 2006;13:625-36 pubmed
    ..Our results accord with previous studies of discrete ACP proteins from fatty acid and aromatic polyketide biosynthesis, suggesting that helix II may also serve as a universal interaction motif in modular PKSs. ..
  25. Hughes M, Gretton S, Shelton H, Brown D, McCormick C, Angus A, et al. A conserved proline between domains II and III of hepatitis C virus NS5A influences both RNA replication and virus assembly. J Virol. 2009;83:10788-96 pubmed publisher
    ..These data point to critical roles for these proline residues at multiple stages in the HCV life cycle; however, they also caution against extrapolation of data from culture-adapted replicons to infectious virus. ..
  26. Urban S, Freeman M. Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain. Mol Cell. 2003;11:1425-34 pubmed
    ..These results provide an explanation of how rhomboid proteases achieve specificity, and allow some rhomboid substrates to be predicted from sequence information. ..
  27. Jennings M, Blankley R, Baron M, Golovanov A, Avis J. Specificity and autoregulation of Notch binding by tandem WW domains in suppressor of Deltex. J Biol Chem. 2007;282:29032-29042 pubmed publisher
    ..The highly conserved tandem arrangement of WW domains in Nedd4 proteins, and similar arrangements in more diverse proteins, suggests domain-domain communication may be integral to regulation of their associated cellular activities. ..
  28. Williams G, Wood A, Williams E, Gao Y, Mercado M, Katz A, et al. Ganglioside inhibition of neurite outgrowth requires Nogo receptor function: identification of interaction sites and development of novel antagonists. J Biol Chem. 2008;283:16641-52 pubmed publisher
    ..Furthermore, the results point to a rational strategy for developing novel ganglioside antagonists. ..
  29. Paszek P, Ryan S, Ashall L, Sillitoe K, Harper C, Spiller D, et al. Population robustness arising from cellular heterogeneity. Proc Natl Acad Sci U S A. 2010;107:11644-9 pubmed publisher
    ..Our analyses suggest in contrast, that this cellular variation might be advantageous and subject to evolutionary selection. Alternative types of therapy could perhaps be designed to modulate this cellular heterogeneity. ..
  30. Delorme V, McCabe P, Kim D, Leaver C. A matrix metalloproteinase gene is expressed at the boundary of senescence and programmed cell death in cucumber. Plant Physiol. 2000;123:917-27 pubmed
    ..Our results suggest that PCD occurs only at the culmination of the senescence program or that the processes are distinct with PCD being triggered at the end of senescence...
  31. Brown S, Hu N, Hombría J. Identification of the first invertebrate interleukin JAK/STAT receptor, the Drosophila gene domeless. Curr Biol. 2001;11:1700-5 pubmed
    ..This suggests that the vertebrate families evolved from a single ancestral receptor that also gave rise to dome. ..
  32. Callaghan A, Redko Y, Murphy L, Grossmann J, Yates D, Garman E, et al. "Zn-link": a metal-sharing interface that organizes the quaternary structure and catalytic site of the endoribonuclease, RNase E. Biochemistry. 2005;44:4667-75 pubmed
    ..One or both interfaces organize the active site, which is distinct from the primary site of RNA binding. ..
  33. Kittler J, Chen G, Honing S, Bogdanov Y, McAinsh K, Arancibia Carcamo I, et al. Phospho-dependent binding of the clathrin AP2 adaptor complex to GABAA receptors regulates the efficacy of inhibitory synaptic transmission. Proc Natl Acad Sci U S A. 2005;102:14871-6 pubmed
    ..Therefore phospho-dependent regulation of AP2 binding to GABA(A)Rs provides a mechanism to specify receptor cell surface number and the efficacy of inhibitory synaptic transmission. ..
  34. Jennings B, Pickles L, Wainwright S, Roe S, Pearl L, Ish Horowicz D. Molecular recognition of transcriptional repressor motifs by the WD domain of the Groucho/TLE corepressor. Mol Cell. 2006;22:645-55 pubmed
    ..Our structural and functional analysis explains the rigid conservation of the WRPW motif, the sequence flexibility of eh1 motifs, and other aspects of repressor recognition by Gro in vivo. ..
  35. Sweeney T, Cisnetto V, Bose D, Bailey M, Wilson J, Zhang X, et al. Foot-and-mouth disease virus 2C is a hexameric AAA+ protein with a coordinated ATP hydrolysis mechanism. J Biol Chem. 2010;285:24347-59 pubmed publisher
    ..Our results provide new insights into the structure and mechanism of picornavirus 2C proteins that will facilitate new investigations of their roles in infection. ..
  36. Andre J, Kerry L, Qi X, Hawkins E, Drizyte K, Ginger M, et al. An alternative model for the role of RP2 protein in flagellum assembly in the African trypanosome. J Biol Chem. 2014;289:464-75 pubmed publisher
  37. Collins B, McCoy A, Kent H, Evans P, Owen D. Molecular architecture and functional model of the endocytic AP2 complex. Cell. 2002;109:523-35 pubmed
    ..A model for AP2 recruitment and activation is proposed. ..
  38. Kerr N, Holmes F, Wynick D. Novel isoforms of the sodium channels Nav1.8 and Nav1.5 are produced by a conserved mechanism in mouse and rat. J Biol Chem. 2004;279:24826-33 pubmed
    ..Mutations of sodium channels within this cytoplasmic loop have previously been demonstrated to alter electrophysiological properties and cause cardiac arrhythmias and epilepsy. ..
  39. Parker J, Bielen A, Dikic I, Ulrich H. Contributions of ubiquitin- and PCNA-binding domains to the activity of Polymerase eta in Saccharomyces cerevisiae. Nucleic Acids Res. 2007;35:881-9 pubmed
    ..Like its mammalian homolog, budding yeast Polymerase eta itself is ubiquitylated in a manner dependent on its ubiquitin-binding domain. ..
  40. Kilkenny M, De Piccoli G, Perera R, Labib K, Pellegrini L. A conserved motif in the C-terminal tail of DNA polymerase α tethers primase to the eukaryotic replisome. J Biol Chem. 2012;287:23740-7 pubmed publisher
    ..These findings indicate that tethering of primase to the replisome by pol α is critical for the normal action of DNA replication forks in eukaryotic cells. ..
  41. Tottey S, Rondet S, Borrelly G, Robinson P, Rich P, Robinson N. A copper metallochaperone for photosynthesis and respiration reveals metal-specific targets, interaction with an importer, and alternative sites for copper acquisition. J Biol Chem. 2002;277:5490-7 pubmed
    ..Conversely, activity in Deltaatx1DeltactaA was less than in either respective single mutant, revealing that Atx1 can function without the major copper importer and consistent with a role in recycling endogenous copper. ..
  42. Chai W, Beeson J, Lawson A. The structural motif in chondroitin sulfate for adhesion of Plasmodium falciparum-infected erythrocytes comprises disaccharide units of 4-O-sulfated and non-sulfated N-acetylgalactosamine linked to glucuronic acid. J Biol Chem. 2002;277:22438-46 pubmed
  43. Biekofsky R, Turjanski A, Estrin D, Feeney J, Pastore A. Ab initio study of NMR 15N chemical shift differences induced by Ca2+ binding to EF-hand proteins. Biochemistry. 2004;43:6554-64 pubmed
    ..The emerging hypothesis from our analysis is that this cooperative network of interactions is essential for stabilizing the "open" conformation of an EF-hand domain. ..
  44. Cai Z, Taddei A, Sheppard D. Differential sensitivity of the cystic fibrosis (CF)-associated mutants G551D and G1349D to potentiators of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel. J Biol Chem. 2006;281:1970-7 pubmed
    ..We conclude that G551D- and G1349D-CFTR have distinct pharmacological profiles and speculate that drug therapy for CF is likely to be mutation-specific. ..
  45. Kenny A, Cousins S, Pinho L, Stephenson F. The integrity of the glycine co-agonist binding site of N-methyl-D-aspartate receptors is a functional quality control checkpoint for cell surface delivery. J Biol Chem. 2009;284:324-33 pubmed publisher
    ..These findings demonstrate that integrity of the glycine co-agonist binding site is a functional checkpoint requisite for efficient cell surface trafficking of assembled NMDA receptors. ..
  46. Narayan V, Halada P, Hernychova L, Chong Y, Zakova J, Hupp T, et al. A multiprotein binding interface in an intrinsically disordered region of the tumor suppressor protein interferon regulatory factor-1. J Biol Chem. 2011;286:14291-303 pubmed publisher
    ..Interestingly, although NPM1, TRIM28, and YB-1 all bind to the Mf2 domain, they have differing amino acid specificities, demonstrating the degree of combinatorial diversity and specificity available through linear interaction motifs. ..
  47. Koo T, Malerba A, Athanasopoulos T, Trollet C, Boldrin L, Ferry A, et al. Delivery of AAV2/9-microdystrophin genes incorporating helix 1 of the coiled-coil motif in the C-terminal domain of dystrophin improves muscle pathology and restores the level of ?1-syntrophin and ?-dystrobrevin in skeletal muscles of mdx mice. Hum Gene Ther. 2011;22:1379-88 pubmed publisher
  48. Burton M, Kapetanaki S, Chernova T, Jamieson A, Dorlet P, Santolini J, et al. A heme-binding domain controls regulation of ATP-dependent potassium channels. Proc Natl Acad Sci U S A. 2016;113:3785-90 pubmed publisher
    ..We discuss the wider implications of these findings and we use the information to present hypotheses for mechanisms of heme-dependent regulation across other ion channels. ..
  49. Cheng K, Noble M, Skamnaki V, Brown N, Lowe E, Kontogiannis L, et al. The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition. J Biol Chem. 2006;281:23167-79 pubmed
    ..The notion of a flexible linker between the sites, which must have more than a minimal number of residues, provides an explanation for recognition and discrimination against different substrates. ..
  50. Merkouropoulos G, Andreasson E, Hess D, Boller T, Peck S. An Arabidopsis protein phosphorylated in response to microbial elicitation, AtPHOS32, is a substrate of MAP kinases 3 and 6. J Biol Chem. 2008;283:10493-9 pubmed publisher
  51. Hawrani A, Howe R, Walsh T, Dempsey C. Origin of low mammalian cell toxicity in a class of highly active antimicrobial amphipathic helical peptides. J Biol Chem. 2008;283:18636-45 pubmed publisher
    ..We highlight a significant role for tryptophan in promoting binding of amphipathic helical peptides to neutral bilayers, augmenting the arsenal of strategies to reduce mammalian toxicity in antimicrobial peptides. ..
  52. Royle S, Bobanovic L, Murrell Lagnado R. Identification of a non-canonical tyrosine-based endocytic motif in an ionotropic receptor. J Biol Chem. 2002;277:35378-85 pubmed
    ..Similar motifs are present in other receptors and may be important for the control of their functional expression. ..
  53. Cavalier Smith T, Chao E. Phylogeny of choanozoa, apusozoa, and other protozoa and early eukaryote megaevolution. J Mol Evol. 2003;56:540-63 pubmed
  54. Blundell C, Almond A, Mahoney D, DeAngelis P, Campbell I, Day A. Towards a structure for a TSG-6.hyaluronan complex by modeling and NMR spectroscopy: insights into other members of the link module superfamily. J Biol Chem. 2005;280:18189-201 pubmed
    ..Here, we propose a mechanism for ternary complex formation that generates higher order helical structures, as may exist in cartilage aggregates. ..
  55. Tewari R, Spaccapelo R, Bistoni F, Holder A, Crisanti A. Function of region I and II adhesive motifs of Plasmodium falciparum circumsporozoite protein in sporozoite motility and infectivity. J Biol Chem. 2002;277:47613-8 pubmed
    ..These data shed new light on the role of the CS protein in sporozoite motility and infectivity. ..
  56. Sullivan M, Hornig N, Porstmann T, Uhlmann F. Studies on substrate recognition by the budding yeast separase. J Biol Chem. 2004;279:1191-6 pubmed
    ..This suggests that separase recognizes both a cleavage site consensus sequence as well as features outside the cleavage site. ..
  57. Dunoyer P, Thomas C, Harrison S, Revers F, Maule A. A cysteine-rich plant protein potentiates Potyvirus movement through an interaction with the virus genome-linked protein VPg. J Virol. 2004;78:2301-9 pubmed
    ..We conclude that PVIP functions as an ancillary factor to support potyvirus movement in plants. ..
  58. Gonzalez B, Schell M, Letcher A, Veprintsev D, Irvine R, Williams R. Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase. Mol Cell. 2004;15:689-701 pubmed
    ..This lobe embraces all of the phosphates of Ins(1,4,5)P3 in a positively charged pocket, explaining the enzyme's substrate specificity and its inability to phosphorylate PtdIns(4,5)P2, the membrane-resident analog of Ins(1,4,5)P3. ..
  59. Hamada F, Bienz M. The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF. Dev Cell. 2004;7:677-85 pubmed
    ..Our evidence indicates that APC is an adaptor between beta-catenin and CtBP and that CtBP lowers the availability of free nuclear beta-catenin for binding to TCF by sequestering APC/beta-catenin complexes. ..
  60. Hughes T, Brady H. Expression of axin2 is regulated by the alternative 5'-untranslated regions of its mRNA. J Biol Chem. 2005;280:8581-8 pubmed
    ..We discuss this complex regulation in the context of the function of Axin2 as a tumor suppressor. ..
  61. Loewen C, Levine T. A highly conserved binding site in vesicle-associated membrane protein-associated protein (VAP) for the FFAT motif of lipid-binding proteins. J Biol Chem. 2005;280:14097-104 pubmed
    ..Finally, we found that human VAP-A could substitute for Scs2 but that it functioned poorly, suggesting that other factors modulate the binding of Scs2 to proteins with FFAT motifs. ..
  62. Baldwin S, Yao S, Hyde R, Ng A, Foppolo S, Barnes K, et al. Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes. J Biol Chem. 2005;280:15880-7 pubmed
    ..However, it was strongly dependent upon pH, and the optimum pH value of 5.5 probably reflected the location of the transporter in acidic, intracellular compartments. ..
  63. Eckert M, Meek S, Ball K. A novel repressor domain is required for maximal growth inhibition by the IRF-1 tumor suppressor. J Biol Chem. 2006;281:23092-102 pubmed
    ..The data link IRF-1 regulatory domains to its growth inhibitory activity and provide information about how differential gene regulation may contribute to IRF-1 tumor suppressor activity. ..
  64. Smith M, Pozo K, Brickley K, Stephenson F. Mapping the GRIF-1 binding domain of the kinesin, KIF5C, substantiates a role for GRIF-1 as an adaptor protein in the anterograde trafficking of cargoes. J Biol Chem. 2006;281:27216-28 pubmed
    ..These findings support a role for GRIF-1 as a kinesin adaptor molecule requisite for the anterograde delivery of defined cargoes such as mitochondria and/or vesicles incorporating beta2 subunit-containing GABAA receptors, in the brain. ..
  65. Grenha R, Rzechorzek N, Brannigan J, de Jong R, Ab E, Diercks T, et al. Structural characterization of Spo0E-like protein-aspartic acid phosphatases that regulate sporulation in bacilli. J Biol Chem. 2006;281:37993-8003 pubmed
    ..The implications of the structures for interactions between the phosphatases and their substrate Spo0A approximately P are discussed. ..
  66. Wayne G, Deng S, Amour A, Borman S, Matico R, Carter H, et al. TIMP-3 inhibition of ADAMTS-4 (Aggrecanase-1) is modulated by interactions between aggrecan and the C-terminal domain of ADAMTS-4. J Biol Chem. 2007;282:20991-8 pubmed
    ..The results of this study therefore indicate that the cartilage environment can modulate the function of enzyme-inhibitor systems and could have relevance for therapeutic approaches to aggrecanase modulation. ..
  67. Alves Silva J, Sánchez Soriano N, Beaven R, Klein M, Parkin J, Millard T, et al. Spectraplakins promote microtubule-mediated axonal growth by functioning as structural microtubule-associated proteins and EB1-dependent +TIPs (tip interacting proteins). J Neurosci. 2012;32:9143-58 pubmed publisher
    ..From our data we deduce a model that relates the different features of the spectraplakin C terminus to the two functions of Shot during axonal growth. ..
  68. Hudson B, Due Hansen M, Christiansen E, Hansen A, MacKenzie A, Murdoch H, et al. Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor. J Biol Chem. 2013;288:17296-312 pubmed publisher
  69. Bulstrode H, Johnstone E, Marqués Torrejón M, Ferguson K, Bressan R, Blin C, et al. Elevated FOXG1 and SOX2 in glioblastoma enforces neural stem cell identity through transcriptional control of cell cycle and epigenetic regulators. Genes Dev. 2017;31:757-773 pubmed publisher
    ..Thus, FOXG1 and SOX2 operate in complementary but distinct roles to fuel unconstrained self-renewal in GBM stem cells via transcriptional control of core cell cycle and epigenetic regulators. ..
  70. Boname J, Stevenson P. MHC class I ubiquitination by a viral PHD/LAP finger protein. Immunity. 2001;15:627-36 pubmed
    ..Thus, gamma-herpesviruses have adapted the cellular PHD/LAP motif to immune evasion, apparently for the catalysis of MHC class I ubiquitination...
  71. Burgar H, Burns H, Elsden J, Lalioti M, Heath J. Association of the signaling adaptor FRS2 with fibroblast growth factor receptor 1 (Fgfr1) is mediated by alternative splicing of the juxtamembrane domain. J Biol Chem. 2002;277:4018-23 pubmed
    ..Activation of signaling pathways from FRS2 is likely to be regulated by controlling the Fgfr1/FRS2 interaction through alternative splicing of the VT motif of Fgfr1. ..
  72. O Reilly D, Quinn C, El Shanawany T, Gordon S, Greaves D. Multiple Ets factors and interferon regulatory factor-4 modulate CD68 expression in a cell type-specific manner. J Biol Chem. 2003;278:21909-19 pubmed
    ..We propose that expression of CD68 in myeloid cells requires the Ets transcription factors Elf-1 and PU.1 and CD68 expression is down-regulated in lymphoid cells by combinatorial interactions between PU.1 and IRF-4. ..
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