Experts and Doctors on alzheimer disease in South Korea


Locale: South Korea
Topic: alzheimer disease

Top Publications

  1. An H, Son S, Cho S, Cho E, Choi B, Kim S. Large intracranial volume accelerates conversion to dementia in males and APOE4 non-carriers with mild cognitive impairment. Int Psychogeriatr. 2016;28:769-78 pubmed publisher
    ..This may be due to its influence on disease trajectory, which shortens the duration of the MCI stage. A longitudinal model of progression trajectory is proposed. ..
  2. Lee S, Kim S, Noh Y, Choi B, Noh G, Park W, et al. Pharmacokinetics of Memantine after a Single and Multiple Dose of Oral and Patch Administration in Rats. Basic Clin Pharmacol Toxicol. 2016;118:122-7 pubmed publisher
    ..However, drug exposure was similar to the oral formulation at each dose. Additionally, the memantine patch formulation displayed a smaller interindividual variability and lower accumulation than the oral formulation. ..
  3. Irwin J, Erisir A, Kwon I. Oral Triphenylmethane Food Dye Analog, Brilliant Blue G, Prevents Neuronal Loss in APPSwDI/NOS2-/- Mouse Model. Curr Alzheimer Res. 2016;13:663-77 pubmed
  4. Song J, Dibattista A, Sung Y, Ahn J, Turner R, Yang J, et al. A tetra(ethylene glycol) derivative of benzothiazole aniline ameliorates dendritic spine density and cognitive function in a mouse model of Alzheimer's disease. Exp Neurol. 2014;252:105-13 pubmed publisher
    ..This behavioral improvement corresponds to a decrease in soluble A? 40 levels. Taken together, these findings suggest that BTA-EG4 may be beneficial in ameliorating the synaptic loss seen in early AD. ..
  5. Van Giau V, An S. Emergence of exosomal miRNAs as a diagnostic biomarker for Alzheimer's disease. J Neurol Sci. 2016;360:141-52 pubmed publisher
    ..We also supply a comprehensive overview of the formation, function, and isolation of exosomes. ..
  6. Choi H, Seo E, Yi D, Sohn B, Choe Y, Byun M, et al. Amyloid-Independent Amnestic Mild Cognitive Impairment and Serum Apolipoprotein A1 Levels. Am J Geriatr Psychiatry. 2016;24:144-53 pubmed publisher
    ..Patients with aMCI- likely exhibit different clinical and pathophysiological characteristics than patients with aMCI+. Additionally, APOA1 may be an important contributor underlying amyloid-independent neurodegeneration. ..
  7. Yun H, Kim H, Park K, Shin J, Kang A, Il Lee K, et al. Placenta-derived mesenchymal stem cells improve memory dysfunction in an A?1-42-infused mouse model of Alzheimer's disease. Cell Death Dis. 2013;4:e958 pubmed publisher
  8. Yang H, Hwang J, Kwon D, Kim M, Kang S, Moon N, et al. Yuzu extract prevents cognitive decline and impaired glucose homeostasis in ?-amyloid-infused rats. J Nutr. 2013;143:1093-9 pubmed publisher
    ..In conclusion, yuzu treatment prevented the cognitive dysfunction and impaired energy and glucose homeostasis induced by ?-amyloid infusion. ..
  9. Choi D, Lee J, Peng J, Lee Y, Han J, Lee Y, et al. Obovatol improves cognitive functions in animal models for Alzheimer's disease. J Neurochem. 2012;120:1048-59 pubmed publisher

More Information


  1. Choi W, Choi C, Kim Y, Kim S, Na C, Lee H. HerDing: herb recommendation system to treat diseases using genes and chemicals. Database (Oxford). 2016;2016: pubmed publisher
    ..HerDing was built by integrating public databases and by applying a text-mining method. The HerDing website is free and open to all users, and there is no login requirement. Database URL: ..
  2. Mun M, Kim J, Choi J, Kim M, Jang W, Lee J, et al. Polymorphisms of small ubiquitin-related modifier genes are associated with risk of Alzheimer's disease in Korean: A case-control study. J Neurol Sci. 2016;364:122-7 pubmed publisher
    ..057, p-value=0.014). Furthermore, three combinations were associated with an increased risk of AD. Our data suggest that three individual polymorphisms and three combinations may be potential risk factors for AD in Korean population. ..
  3. Yi J, Park H, Lee S, Jung J, Kim B, Lee Y, et al. Cassia obtusifolia seed ameliorates amyloid β-induced synaptic dysfunction through anti-inflammatory and Akt/GSK-3β pathways. J Ethnopharmacol. 2016;178:50-7 pubmed publisher
    ..In the in vivo studies performed, COE ameliorated the Aβ-induced object recognition memory impairment. These results suggest that COE exhibits neuroprotective activities against Aβ-induced brain disorders. ..
  4. Dong H, Gim J, Yeo S, Kim H. Integrated late onset Alzheimer's disease (LOAD) susceptibility genes: Cholesterol metabolism and trafficking perspectives. Gene. 2017;597:10-16 pubmed publisher
    ..Additional experimental and bioinformatic approaches to integrate data from genetics, epigenetics, and molecular networks may further increase our understanding of LOAD in relation to cholesterol metabolism and trafficking. ..
  5. Chun Y, Kwon O, Chung S. O-GlcNAcylation of amyloid-? precursor protein at threonine 576 residue regulates trafficking and processing. Biochem Biophys Res Commun. 2017;490:486-491 pubmed publisher
    ..Thus, specific O-GlcNAcylation of APP at Thr 576 may be a novel and promising drug target for AD therapeutics. ..
  6. Yi D, Seo E, Han J, Sohn B, Byun M, Lee J, et al. Development of the Korean Adult Reading Test (KART) to estimate premorbid intelligence in dementia patients. PLoS ONE. 2017;12:e0181523 pubmed publisher
    ..In conclusion, the results support the validity of KART-predicted IQ as an index of premorbid IQ in individuals with AD. ..
  7. Lee K, Lee J, Kim K, Jhoo J, Lee D, Yoon J, et al. Influence of the apolipoprotein E type 4 allele on cerebral glucose metabolism in Alzheimer's disease patients. J Neuropsychiatry Clin Neurosci. 2003;15:78-83 pubmed
    ..These findings favor the hypothesis that APOE E4 is related mainly to the development of AD, not to its progression. ..
  8. Park K, Kim E, Han H, Shim Y, Kwon J, Ku B, et al. Efficacy and tolerability of rivastigmine patch therapy in patients with mild-to-moderate Alzheimer's dementia associated with minimal and moderate ischemic white matter hyperintensities: A multicenter prospective open-label clinical trial. PLoS ONE. 2017;12:e0182123 pubmed publisher NCT01380288. ..
  9. Kim W, Noh H, Lee Y, Jeon J, Shanmugavadivu A, McPhie D, et al. MiR-126 Regulates Growth Factor Activities and Vulnerability to Toxic Insult in Neurons. Mol Neurobiol. 2016;53:95-108 pubmed publisher
  10. Park S, Shin J, Jeong J, Song J, Jo Y, Kim E, et al. Down-regulation of mortalin exacerbates A?-mediated mitochondrial fragmentation and dysfunction. J Biol Chem. 2014;289:2195-204 pubmed publisher
    ..Taken together, our results suggest that down-regulation of mortalin may potentiate A?-mediated mitochondrial fragmentation and dysfunction in AD. ..
  11. Li L, Li W, Jung S, Lee Y, Kim Y. Protective effects of decursin and decursinol angelate against amyloid ?-protein-induced oxidative stress in the PC12 cell line: the role of Nrf2 and antioxidant enzymes. Biosci Biotechnol Biochem. 2011;75:434-42 pubmed
    ..Thus D and DA have therapeutic potential in treating AD and other oxidative stress-related diseases...
  12. Lee Y, Choi I, Ban J, Lee H, Lee U, Han S, et al. 4-O-methylhonokiol attenuated ?-amyloid-induced memory impairment through reduction of oxidative damages via inactivation of p38 MAP kinase. J Nutr Biochem. 2011;22:476-86 pubmed publisher
    ..These results suggest that 4-O-MH might prevent the development and progression of AD through the reduction of oxidative stress and neuronal cell death via inactivation of p38 MAP kinase pathway...
  13. Kim J, Bareiss S, Kim K, Tatum R, Han J, Jin Y, et al. Presenilin-1 inhibits delta-catenin-induced cellular branching and promotes delta-catenin processing and turnover. Biochem Biophys Res Commun. 2006;351:903-8 pubmed
    ..Together, our findings suggest that PS-1 can affect delta-catenin-induced morphogenesis possibly through the regulation of its processing and stability. ..
  14. Ha T, Cho D, Park S, Joo M, Lee B, Kong B, et al. Evaluating associations between 5-HTTLPR polymorphism and Alzheimer's disease for Korean patients. Dement Geriatr Cogn Disord. 2005;20:31-4 pubmed
    ..The 5-HTTLPR polymorphism was neither associated with AD nor with delusional/aggressive symptoms of AD. It was suggested that phenotypic expression of the 5-HTTLPR polymorphism might be varied according to ethnic differences. ..
  15. Kim J, Stewart R, Shin I, Jung J, Yoon J. Assessment of association between mitochondrial aldehyde dehydrogenase polymorphism and Alzheimer's disease in an older Korean population. Neurobiol Aging. 2004;25:295-301 pubmed
    ..058). Overall, these findings in a community population did not support a substantial role for ALDH2 genotype in the aetiology of dementia. ..