Experts and Doctors on alcohol withdrawal seizures in United States


Locale: United States
Topic: alcohol withdrawal seizures

Top Publications

  1. Mark G, Finn D. The relationship between hippocampal acetylcholine release and cholinergic convulsant sensitivity in withdrawal seizure-prone and withdrawal seizure-resistant selected mouse lines. Alcohol Clin Exp Res. 2002;26:1141-52 pubmed
    ..Specifically, WSP mice may have lower sensitivity to cholinergic convulsants compared with WSR because of postsynaptic receptor desensitization brought on by higher activity of cholinergic neurons. ..
  2. Feng H, Faingold C. The effects of chronic ethanol administration on amygdala neuronal firing and ethanol withdrawal seizures. Neuropharmacology. 2008;55:648-53 pubmed publisher
  3. STEPANYAN T, Farook J, Kowalski A, Kaplan E, Barron S, Littleton J. Alcohol withdrawal-induced hippocampal neurotoxicity in vitro and seizures in vivo are both reduced by memantine. Alcohol Clin Exp Res. 2008;32:2128-35 pubmed publisher
    ..The potential role of memantine in treatment of alcoholism is deserving of further study. ..
  4. Olive M, Becker H. Effects of the mGluR2/3 agonist LY379268 and the mGluR5 antagonist MPEP on handling-induced convulsions during ethanol withdrawal in mice. Alcohol. 2008;42:191-7 pubmed publisher
  5. Becker H, Veatch L. Effects of lorazepam treatment for multiple ethanol withdrawals in mice. Alcohol Clin Exp Res. 2002;26:371-80 pubmed
  6. Faingold C. Role of GABA abnormalities in the inferior colliculus pathophysiology - audiogenic seizures. Hear Res. 2002;168:223-37 pubmed
    ..These neurotransmitter abnormalities result in excessive firing of ICc neurons that acts as the critical initiation mechanism for triggering seizures in response to intense acoustic stimuli. ..
  7. Becker H, Myrick H, Veatch L. Pregabalin is effective against behavioral and electrographic seizures during alcohol withdrawal. Alcohol Alcohol. 2006;41:399-406 pubmed
    ..Collectively, these results suggest that pregabalin may be an effective therapeutic agent for medical management of alcohol detoxification. ..
  8. Denmark D, Buck K. Molecular analyses and identification of promising candidate genes for loci on mouse chromosome 1 affecting alcohol physical dependence and associated withdrawal. Genes Brain Behav. 2008;7:599-608 pubmed publisher
    ..Thus, our results will be primary to further efforts to identify genes involved in a wide variety of behavioral responses to alcohol and may directly facilitate progress in human alcoholism genetics. ..
  9. Finn D, Gallaher E, Crabbe J. Differential change in neuroactive steroid sensitivity during ethanol withdrawal. J Pharmacol Exp Ther. 2000;292:394-405 pubmed
    ..These results suggest that sensitization to the anticonvulsant effect of 3alpha,5alpha-P during EtOH withdrawal does not generalize across all genotypes nor does it generalize to all of the pharmacological effects of 3alpha,5alpha-P...

More Information


  1. Strong M, Kaufman K, Crabbe J, Finn D. Sex differences in acute ethanol withdrawal severity after adrenalectomy and gonadectomy in Withdrawal Seizure-Prone and Withdrawal Seizure-Resistant mice. Alcohol. 2009;43:367-77 pubmed publisher
  2. Faingold C, Knapp D, Chester J, Gonzalez L. Integrative neurobiology of the alcohol withdrawal syndrome--from anxiety to seizures. Alcohol Clin Exp Res. 2004;28:268-78 pubmed
  3. Blednov Y, Benavidez J, Homanics G, Harris R. Behavioral characterization of knockin mice with mutations M287L and Q266I in the glycine receptor ?1 subunit. J Pharmacol Exp Ther. 2012;340:317-29 pubmed publisher
    ..Thus, in addition to reducing ethanol action on the GlyRs, these mutations reduced glycinergic inhibition, which may also alter sensitivity to GABAergic drugs...
  4. McMicken D, Liss J. Alcohol-related seizures. Emerg Med Clin North Am. 2011;29:117-24 pubmed publisher
    ..Benzodiazepines alone are sufficient to prevent AWS. The alcoholic patient with a documented history of ARS, who experiences a single seizure or a short burst of seizures should be treated with lorazepam, 2 mg intravenously...
  5. Karpyak V, Kim J, Biernacka J, Wieben E, Mrazek D, Black J, et al. Sequence variations of the human MPDZ gene and association with alcoholism in subjects with European ancestry. Alcohol Clin Exp Res. 2009;33:712-21 pubmed publisher
    ..Further functional genomic analysis of MPDZ variants and investigation of their association with a broader array of alcoholism-related phenotypes could reveal additional genetic markers of alcoholism. ..
  6. Hwa L, Chu A, Levinson S, Kayyali T, DeBold J, Miczek K. Persistent escalation of alcohol drinking in C57BL/6J mice with intermittent access to 20% ethanol. Alcohol Clin Exp Res. 2011;35:1938-47 pubmed publisher
    ..Intermittent 24-hour cycles of ethanol access and deprivation can generate high levels of voluntary ethanol drinking in rats...
  7. Philibin S, Cameron A, Metten P, Crabbe J. Motor impairment: a new ethanol withdrawal phenotype in mice. Behav Pharmacol. 2008;19:604-14 pubmed publisher
    ..The accelerating rotarod seems to be a simple behavioral measure of ethanol withdrawal that is suitable for comparing genotypes...
  8. Ningaraj N, Chen W, Schloss J, Faiman M, Wu J. S-methyl-N,N-diethylthiocarbamate sulfoxide elicits neuroprotective effect against N-methyl-D-aspartate receptor-mediated neurotoxicity. J Biomed Sci. 2001;8:104-13 pubmed
    ..These data demonstrate that DETC-MeSO produces the neuroprotective effect through antagonism of NMDA receptors in vivo...
  9. Kozell L, Belknap J, Hofstetter J, Mayeda A, Buck K. Mapping a locus for alcohol physical dependence and associated withdrawal to a 1.1 Mb interval of mouse chromosome 1 syntenic with human chromosome 1q23.2-23.3. Genes Brain Behav. 2008;7:560-7 pubmed publisher
    ..Thus, the fine mapping of this QTL and analyses of the genes within the QTL interval can inform developing models for genetic determinants of alcohol dependence in humans...
  10. Finn D, Douglass A, Beadles Bohling A, Tanchuck M, Long S, Crabbe J. Selected line difference in sensitivity to a GABAergic neurosteroid during ethanol withdrawal. Genes Brain Behav. 2006;5:53-63 pubmed
    ..These findings suggest that mice selectively bred for differences in EtOH withdrawal severity are differentially sensitive to ALLO during EtOH withdrawal...
  11. Faingold C. The Majchrowicz binge alcohol protocol: an intubation technique to study alcohol dependence in rats. Curr Protoc Neurosci. 2008;Chapter 9:Unit 9.28 pubmed publisher
    ..One specific behavior observed during ethanol withdrawal and described here is sound-induced (audiogenic) convulsive seizure. ..
  12. Farook J, Krazem A, Lewis B, Morrell D, Littleton J, Barron S. Acamprosate attenuates the handling induced convulsions during alcohol withdrawal in Swiss Webster mice. Physiol Behav. 2008;95:267-270 pubmed publisher
    ..05). This study supports the use of acamprosate during periods of alcohol withdrawal as well as during abstinence...
  13. Chen G, Kozell L, Hitzemann R, Buck K. Involvement of the limbic basal ganglia in ethanol withdrawal convulsivity in mice is influenced by a chromosome 4 locus. J Neurosci. 2008;28:9840-9 pubmed publisher
    ..This mouse QTL is syntenic with human chromosome 9p. Given the growing body of evidence that a gene(s) on chromosome 9p influences alcoholism, our results can facilitate human research on alcohol dependence and withdrawal...
  14. Veatch L, Wright T, Randall C. Only male mice show sensitization of handling-induced convulsions across repeated ethanol withdrawal cycles. Alcohol Clin Exp Res. 2007;31:477-85 pubmed
  15. Feng H, Yang L, Faingold C. Role of the amygdala in ethanol withdrawal seizures. Brain Res. 2007;1141:65-73 pubmed
    ..These findings suggest a critical role of the amygdala in the ETX seizure network in generating tonic convulsions during AGS...
  16. Kim J, Karpyak V, Biernacka J, Nam H, Lee M, Preuss U, et al. Functional role of the polymorphic 647 T/C variant of ENT1 (SLC29A1) and its association with alcohol withdrawal seizures. PLoS ONE. 2011;6:e16331 pubmed publisher
    ..Interestingly, in humans, the ENT1 (SLC29A1) gene contains a non-synonymous single nucleotide polymorphism (647 T/C; rs45573936) that might be involved in the functional change of ENT1...
  17. Voris J, Smith N, Rao S, Thorne D, Flowers Q. Gabapentin for the treatment of ethanol withdrawal. Subst Abus. 2003;24:129-32 pubmed
    ..Both sets of data suggest that gabapentin works well for the mild to moderate alcohol withdrawal patient...
  18. Schafer G, Crabbe J, Wiren K. Ethanol-regulated gene expression of neuroendocrine specific protein in mice: brain region and genotype specificity. Brain Res. 2001;897:139-49 pubmed
    ..Overall, the results indicate a complex pattern of ethanol-induced regulation of the putative mouse homologue of RTN1 and suggest that specific brain regional changes may be involved in the expression of physical dependence. ..
  19. Tanchuck M, Cozzoli D, He I, Kaufman K, Snelling C, Crabbe J, et al. Local changes in neurosteroid levels in the substantia nigra reticulata and the ventral tegmental area alter chronic ethanol withdrawal severity in male withdrawal seizure-prone mice. Alcohol Clin Exp Res. 2013;37:784-93 pubmed publisher
    ..Thus, EtOH withdrawal reduced sensitivity of GABAA Rs to GABAergic neurosteroids in 2 neuroanatomical substrates within the basal ganglia in WSP-1 male mice. ..