Genomes and Genes
Experts and Doctors on aging in United States
Locale: United States
Publications914 found, 100 shown here
- Thomas B, Liu P, Park D, van Osch M, Lu H. Cerebrovascular reactivity in the brain white matter: magnitude, temporal characteristics, and age effects. J Cereb Blood Flow Metab. 2014;34:242-7 pubmed publisher..These data suggest that characteristics of WM CVR are different from that of GM and caution should be used when interpreting pathologic WM CVR results. ..
- Lass J, Benetz B, Gal R, Kollman C, Raghinaru D, Dontchev M, et al. Donor age and factors related to endothelial cell loss 10 years after penetrating keratoplasty: Specular Microscopy Ancillary Study. Ophthalmology. 2013;120:2428-2435 pubmed publisher..Greater preoperative ECD and larger donor tissue size are associated with higher ECD at 10 years. ..
- Germain C, Vasquez E, Batsis J. Physical Activity, Central Adiposity, and Functional Limitations in Community-Dwelling Older Adults. J Geriatr Phys Ther. 2016;39:71-6 pubmed publisher..Additional research is needed to determine whether physical activity moderates long-term physical and functional limitations. ..
- Bracciali C, Guzzo G, Giacoma C, Dean J, SarÃ G. Fish functional traits are affected by hydrodynamics at small spatial scale. Mar Environ Res. 2016;113:116-23 pubmed publisher..Individuals smaller than 60-mm were more abundant under low-hydrodynamics. Morphometric analysis revealed that high-hydrodynamics were favored by fish with a more fusiform body shape and body traits developed for propellant swimming. ..
- Volovitz B, Welliver R, De Castro G, Krystofik D, Ogra P. The release of leukotrienes in the respiratory tract during infection with respiratory syncytial virus: role in obstructive airway disease. Pediatr Res. 1988;24:504-7 pubmed..abstract truncated at 250 words) ..
- Viner R, Ferrington D, Williams T, Bigelow D, SCHONEICH C. Protein modification during biological aging: selective tyrosine nitration of the SERCA2a isoform of the sarcoplasmic reticulum Ca2+-ATPase in skeletal muscle. Biochem J. 1999;340 ( Pt 3):657-69 pubmed
- Alnouti Y, Petrick J, Klaassen C. Tissue distribution and ontogeny of organic cation transporters in mice. Drug Metab Dispos. 2006;34:477-82 pubmed..Furthermore, low expression of the Octs in young animals may affect the pharmacokinetic behavior of drugs compared with that in adults. ..
- Wu M, Desai D, Kakarla S, Katta A, Paturi S, Gutta A, et al. Acetaminophen prevents aging-associated hyperglycemia in aged rats: effect of aging-associated hyperactivation of p38-MAPK and ERK1/2. Diabetes Metab Res Rev. 2009;25:279-86 pubmed publisher..8%; p<0.05) and reduced p38-MAPK and ERK1/2 hyperactivation (-50.4% and -35.4%, respectively; p<0.05). These results suggest that acetaminophen may be useful for the treatment of age-associated hyperglycemia. ..
- Kingan S, Garrigan D, Hartl D. Recurrent selection on the Winters sex-ratio genes in Drosophila simulans. Genetics. 2010;184:253-65 pubmed publisher..We discuss the possible causes of the maintenance of presence-absence polymorphism in the Winters sex-ratio genes. ..
- Li L, Smith A, Hagen T, Frei B. Vascular oxidative stress and inflammation increase with age: ameliorating effects of alpha-lipoic acid supplementation. Ann N Y Acad Sci. 2010;1203:151-9 pubmed publisher..Furthermore, LA reversed the age-dependent changes in aortic SOD activity and plasma MCP-1 levels. Hence, vascular oxidative stress and inflammation increase with age and are ameliorated by LA supplementation. ..
- Carrino D, Calabro A, Darr A, Dours Zimmermann M, Sandy J, Zimmermann D, et al. Age-related differences in human skin proteoglycans. Glycobiology. 2011;21:257-68 pubmed publisher..These age-related differences in proteoglycan patterns and catabolism may play a role in the age-related changes in the physical properties and injury response of human skin. ..
- Caires K, de Avila J, Cupp A, McLean D. VEGFA family isoforms regulate spermatogonial stem cell homeostasis in vivo. Endocrinology. 2012;153:887-900 pubmed publisher..Future in vivo and in vitro experimentation will focus on elucidating the mechanisms by which VEGFA isoforms regulate SSC homeostasis. ..
- Kahana E, Kelley Moore J, Kahana B. Proactive aging: a longitudinal study of stress, resources, agency, and well-being in late life. Aging Ment Health. 2012;16:438-51 pubmed publisher..Findings suggest that older adults can maintain successful aging even in the face of health-related and social stressors by invoking accumulated resources to deal actively with the challenges of aging. ..
- Klein R, Lee K, Gangnon R, Klein B. Relation of smoking, drinking, and physical activity to changes in vision over a 20-year period: the Beaver Dam Eye Study. Ophthalmology. 2014;121:1220-8 pubmed publisher..To describe the relationships of lifestyle characteristics to changes in vision and incidence of visual impairment (VI) over a 20-year period in the Beaver Dam Eye Study (BDES)...
- Bakken T, Miller J, Ding S, Sunkin S, Smith K, Ng L, et al. A comprehensive transcriptional map of primate brain development. Nature. 2016;535:367-75 pubmed publisher..Human developmental expression trajectories are more similar to monkey than rodent, although approximately 9% of genes show human-specific regulation with evidence for prolonged maturation or neoteny compared to monkey. ..
- Arif A, Terenzi F, Potdar A, Jia J, Sacks J, China A, et al. EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice. Nature. 2017;542:357-361 pubmed publisher..Thus, EPRS and FATP1 are terminal mTORC1-S6K1 axis effectors that are critical for metabolic phenotypes. ..
- Zayas Santiago A, Cross S, Stanton J, Marmorstein A, Marmorstein L. Mutant Fibulin-3 Causes Proteoglycan Accumulation and Impaired Diffusion Across Bruch's Membrane. Invest Ophthalmol Vis Sci. 2017;58:3046-3054 pubmed publisher..Fibulin-3 ablation results in altered sizes of proteoglycans, altered distributions of MMP-2, MMP-9, and TIMP-3, and enhances diffusion across Bruch's membrane. ..
- Gaydos J, Stallknecht D, Kavanaugh D, Olson R, Fuchs E. Dynamics of maternal antibodies to hemorrhagic disease viruses (Reoviridae: Orbivirus) in white-tailed deer. J Wildl Dis. 2002;38:253-7 pubmed..This may be due to acquired immunity and the subsequent transfer of maternal antibodies, but it does not exclude innate resistance as a possible factor in the enzootic stability of EHD and BT viruses at this location. ..
- Adjan V, Centers A, Jennes L. Expression and activation of N-methyl-D-aspartate receptor subunit-1 receptor subunits in gonadotrophin-releasing hormone neurones of young and middle-aged mice during the luteinising hormone surge. J Neuroendocrinol. 2008;20:1147-54 pubmed publisher..However, both, the expression and activation of NMDAR1 receptor subunits are greatly reduced in the middle-aged animals, which could result in the absence of LH surges. ..
- Babizhayev M, Nikolayev G, Goryachev S, Bours J, Martin R. Hydration properties of the molecular chaperone alpha-crystallin in the bovine lens. Biochemistry (Mosc). 2003;68:1145-55 pubmed
- Lewis M, Phillips G, Bowser M, DeLuca S, Johnson H, Rosen T. Cocaine-exposed infant behavior during Still-Face: risk factor analyses. Am J Orthopsychiatry. 2009;79:60-70 pubmed publisher..Because this interaction was evident in this cohort at 24 months, future research is needed to determine at what age an interaction begins to emerge in this cohort. ..
- Rasband M, Peles E, Trimmer J, Levinson S, Lux S, Shrager P. Dependence of nodal sodium channel clustering on paranodal axoglial contact in the developing CNS. J Neurosci. 1999;19:7516-28 pubmed..In Shiverer, ankyrin-3/G labeling was abnormal, suggesting that its localization also depends on axoglial contact. ..
- Nakatsuka T, Furue H, Yoshimura M, Gu J. Activation of central terminal vanilloid receptor-1 receptors and alpha beta-methylene-ATP-sensitive P2X receptors reveals a converged synaptic activity onto the deep dorsal horn neurons of the spinal cord. J Neurosci. 2002;22:1228-37 pubmed..These convergent pathways may provide a mechanism of sensory integration for two chemically defined sensory inputs and may have implications in different sensory states. ..
- Walton J, Simon H, Frisina R. Age-related alterations in the neural coding of envelope periodicities. J Neurophysiol. 2002;88:565-78 pubmed..We postulate that this age-related difference in rate coding of SAM noise carriers is consistent with a loss, or imbalance, of excitatory and inhibitory neural mechanisms known to shape encoding of envelope periodicities in the IC...
- Bartke A, Brown Borg H. Life extension in the dwarf mouse. Curr Top Dev Biol. 2004;63:189-225 pubmed..An important role of IGF-1 and insulin in the control of mammalian longevity is consistent with the well-documented actions of homologous signaling pathways in invertebrates. ..
- Masternak M, Al Regaiey K, Bonkowski M, Panici J, Bartke A. Effect of every other day feeding diet on gene expression in normal and in long-lived Ames dwarf mice. Exp Gerontol. 2005;40:491-7 pubmed..The results indicate that EOD produces some changes in the insulin and IGF1 signaling pathways, and that these changes are consistent with EOD increasing insulin sensitivity. ..
- Lee J, Gordon S, Estrada R, Wang L, Siow D, Wattenberg B, et al. Balance of S1P1 and S1P2 signaling regulates peripheral microvascular permeability in rat cremaster muscle vasculature. Am J Physiol Heart Circ Physiol. 2009;296:H33-42 pubmed publisher..These data suggest that the balance between S1P(1) and S1P(2) signaling regulates the homeostasis of microvascular permeability in the peripheral circulation and, thus, may affect total peripheral vascular resistance. ..
- McClelland R, Nasir K, Budoff M, Blumenthal R, Kronmal R. Arterial age as a function of coronary artery calcium (from the Multi-Ethnic Study of Atherosclerosis [MESA]). Am J Cardiol. 2009;103:59-63 pubmed publisher..79 using arterial age, p = 0.006). In conclusion, arterial age provides a convenient transformation of CAC from Agatston units to a scale more easily appreciated by patients and treating physicians. ..
- Gao Q, Zhan P, Alander C, Kream B, Hao C, Breyer M, et al. Effects of global or targeted deletion of the EP4 receptor on the response of osteoblasts to prostaglandin in vitro and on bone histomorphometry in aged mice. Bone. 2009;45:98-103 pubmed publisher..We conclude that expression of the EP4 receptor in osteoblasts is critical for anabolic responses to PGE(2) in cell culture but may not be essential for maintenance of bone remodeling in vivo. ..
- Blagosklonny M. Molecular damage in cancer: an argument for mTOR-driven aging. Aging (Albany NY). 2011;3:1130-41 pubmed..I also discuss how random molecular damage, via rounds of multiplication and selection, brings about non-random hallmarks of cancer. ..
- Martin P, Kelly N, Kahana B, Kahana E, Willcox B, Willcox D, et al. Defining successful aging: a tangible or elusive concept?. Gerontologist. 2015;55:14-25 pubmed publisher..The extent of rapid social and technological change influencing views on successful aging also deserves more consideration. ..
- Ucar D, MÃ¡rquez E, Chung C, Marches R, Rossi R, Uyar A, et al. The chromatin accessibility signature of human immune aging stems from CD8+ T cells. J Exp Med. 2017;214:3123-3144 pubmed publisher..Thus, our study provides a unique and comprehensive approach to identifying candidate biomarkers and provides mechanistic insights into aging-associated immunodeficiency. ..
- Krefft T, Graff Radford N, Lucas J, Mortimer J. Normal pressure hydrocephalus and large head size. Alzheimer Dis Assoc Disord. 2004;18:35-7 pubmed..This was found in both males and females. Results suggest that a significant proportion of patients with NPH may have congenital hydrocephalus that becomes symptomatic later in life. ..
- Dremina E, Sharov V, SCHONEICH C. Protein tyrosine nitration in rat brain is associated with raft proteins, flotillin-1 and alpha-tubulin: effect of biological aging. J Neurochem. 2005;93:1262-71 pubmed..The putative mechanism of nitric oxide synthase (NOS) activity regulation by the level of caveolin expression and raft protein-protein interactions is discussed. ..
- Knyushko T, Sharov V, Williams T, SCHONEICH C, Bigelow D. 3-Nitrotyrosine modification of SERCA2a in the aging heart: a distinct signature of the cellular redox environment. Biochemistry. 2005;44:13071-81 pubmed
- Bowman A, Glendening C, Wittum T, Lejeune J, Stich R, Funk J. Prevalence of Yersinia enterocolitica in different phases of production on swine farms. J Food Prot. 2007;70:11-6 pubmed..1% (26.7% of which were ail positive), yet YE was never detected from the farrowing sows. These results represent the first on-farm description of YE in U.S. herds and provide the initial step for designing future studies of YE. ..
- Terenzi F, Brimacombe K, Penn M, Ladd A. CELF-mediated alternative splicing is required for cardiac function during early, but not later, postnatal life. J Mol Cell Cardiol. 2009;46:395-404 pubmed publisher..Our results suggest that CELF proteins are key players in the integrated gene expression program involved in postnatal cardiac remodeling and maturation. ..
- Chintala S, Novak E, Spernyak J, Mazurchuk R, Torres G, Patel S, et al. The Vps33a gene regulates behavior and cerebellar Purkinje cell number. Brain Res. 2009;1266:18-28 pubmed publisher..In general, the bf mutant may be a potentially new and useful model for understanding Purkinje cell development and function. ..
- Osterhage J, Friedman K. Chromosome end maintenance by telomerase. J Biol Chem. 2009;284:16061-5 pubmed publisher..This minireview provides an overview of telomerase structure, function, and regulation and the role of telomerase in human disease. ..
- Pacheco J, Beevers C, Benavides C, McGeary J, Stice E, Schnyer D. Frontal-limbic white matter pathway associations with the serotonin transporter gene promoter region (5-HTTLPR) polymorphism. J Neurosci. 2009;29:6229-33 pubmed publisher..5-HTTLPR genotype and age appear to independently influence the WM microstructure of the UF. The observed reduction in FA values among low-expressing 5-HTTLPR allele carriers may contribute to biased regulation of emotional stimuli. ..
- Garrett K, Pierce S, Embertson R, Stromberg A. Endoscopic evaluation of arytenoid function and epiglottic structure in Thoroughbred yearlings and association with racing performance at two to four years of age: 2,954 cases (1998-2001). J Am Vet Med Assoc. 2010;236:669-73 pubmed publisher..Yearlings with grade II.2 AF, an ES grade > II, or a short epiglottis typically had decreases in racing performance. These factors should be evaluated carefully when developing purchase recommendations. ..
- Hu X, Zhou X, He W, Yang J, Xiong W, Wong P, et al. BACE1 deficiency causes altered neuronal activity and neurodegeneration. J Neurosci. 2010;30:8819-29 pubmed publisher..The knowledge from this study is crucial for the development of BACE1 inhibitors for Alzheimer's therapy and to the applicative study of epilepsy. ..
- Grummer R, Wiltbank M, Fricke P, Watters R, Silva Del Rio N. Management of dry and transition cows to improve energy balance and reproduction. J Reprod Dev. 2010;56 Suppl:S22-8 pubmed..A current study is being performed in a large commercial dairy to examine the effects of eliminating the dry period on reproduction utilizing a large commercial dairy. ..
- Boparai R, Arum O, Khardori R, Bartke A. Glucose homeostasis and insulin sensitivity in growth hormone-transgenic mice: a cross-sectional analysis. Biol Chem. 2010;391:1149-55 pubmed publisher..In addition, they pose intriguing queries about the relationships between GH, endocrine control of metabolism, and aging. ..
- Shaffery J, Lopez J, Roffwarg H. Brain-derived neurotrophic factor (BDNF) reverses the effects of rapid eye movement sleep deprivation (REMSD) on developmentally regulated, long-term potentiation (LTP) in visual cortex slices. Neurosci Lett. 2012;513:84-8 pubmed publisher..The results suggest that REMSD blocks BDNF expression and also maturation of inhibitory processes in adolescent visual cortex. These data support REMS' function in brain development. ..
- Dennis S, Sheth U, Feldman J, English K, Priess J. C. elegans germ cells show temperature and age-dependent expression of Cer1, a Gypsy/Ty3-related retrotransposon. PLoS Pathog. 2012;8:e1002591 pubmed publisher..These studies introduce C. elegans as a model to study the interplay between retroelements and germ cell biology...
- Richdale K, Bullimore M, Sinnott L, Zadnik K. The Effect of Age, Accommodation, and Refractive Error on the Adult Human Eye. Optom Vis Sci. 2016;93:3-11 pubmed publisher..Further testing and development of accommodating intraocular lenses should account for differences in patients' preoperative refractive error. ..
- Schumpert C, Anderson C, Dudycha J, Patel R. Involvement of Daphnia pulicaria Sir2 in regulating stress response and lifespan. Aging (Albany NY). 2016;8:402-17 pubmed..Sir2 knockdown severely reduced both the median lifespan as well as significantly increased mortality following heat shock. Our study provides the first characterization and functional study of Daphnia Sir2. ..
- Harper S, Brack A, MacDonnell S, Franti M, Olwin B, Bailey B, et al. Is Growth Differentiation Factor 11 a Realistic Therapeutic for Aging-Dependent Muscle Defects?. Circ Res. 2016;118:1143-50; discussion 1150 pubmed publisher..Finally, high [GDF11] causes reductions in body and heart weight in both young and old animals, suggestive of a cachexia effect. Our conclusion is that elevating blood levels of GDF11 in the aged might cause more harm than good. ..
- Kerner J, Turkaly P, Minkler P, Hoppel C. Aging skeletal muscle mitochondria in the rat: decreased uncoupling protein-3 content. Am J Physiol Endocrinol Metab. 2001;281:E1054-62 pubmed
- Gerhardt G, Cass W, Yi A, Zhang Z, Gash D. Changes in somatodendritic but not terminal dopamine regulation in aged rhesus monkeys. J Neurochem. 2002;80:168-77 pubmed
- Basha M, Wei W, Bakheet S, Benitez N, Siddiqi H, Ge Y, et al. The fetal basis of amyloidogenesis: exposure to lead and latent overexpression of amyloid precursor protein and beta-amyloid in the aging brain. J Neurosci. 2005;25:823-9 pubmed..These data suggested that environmental influences occurring during brain development predetermined the expression and regulation of APP later in life, potentially altering the course of amyloidogenesis. ..
- Croft M, Glasser A, Heatley G, McDonald J, Ebbert T, Dahl D, et al. Accommodative ciliary body and lens function in rhesus monkeys, I: normal lens, zonule and ciliary process configuration in the iridectomized eye. Invest Ophthalmol Vis Sci. 2006;47:1076-86 pubmed..Ciliary body centripetal movement may not be the limiting component in accommodation in the older eye. ..
- Grover S, Murthy R, Brar V, Chalam K. Normative data for macular thickness by high-definition spectral-domain optical coherence tomography (spectralis). Am J Ophthalmol. 2009;148:266-71 pubmed publisher..To establish normative data for the macular thickness by spectral-domain optical coherence tomography (SD-OCT) in subjects with no known retinal disease...
- Schulz D, Mirrione M, Henn F. Cognitive aspects of congenital learned helplessness and its reversal by the monoamine oxidase (MAO)-B inhibitor deprenyl. Neurobiol Learn Mem. 2010;93:291-301 pubmed publisher..did not alter locomotion/exploration or 'anxiety' in the open field. In conclusion, helplessness may be related to altered mechanisms of reinforcement learning and working memory, and to abnormalities in MAO-A and/or MAO-B functioning. ..
- Summers C, Bohman T, Gillam R, PENA E, Bedore L. Bilingual performance on nonword repetition in Spanish and English. Int J Lang Commun Disord. 2010;45:480-93 pubmed publisher..This knowledge may shift across levels of bilingualism. Further research is needed to understand this relationship, as it is likely to have implications for language teaching or intervention for children with language impairments. ..
- Burroughs S, Kaja S, Koulen P. Quantification of deficits in spatial visual function of mouse models for glaucoma. Invest Ophthalmol Vis Sci. 2011;52:3654-9 pubmed publisher..Given the similar increases in IOP and contrast sensitivity threshold and loss of visual acuity between these two DBA/2 substrains, we also conclude that DBA/2NHsd mice are a suitable alternative model for pigmentary glaucoma. ..
- Rodova M, Lu Q, Li Y, Woodbury B, Crist J, Gardner B, et al. Nfat1 regulates adult articular chondrocyte function through its age-dependent expression mediated by epigenetic histone methylation. J Bone Miner Res. 2011;26:1974-86 pubmed publisher..Age-dependent Nfat1 expression in articular chondrocytes is regulated by dynamic histone methylation, one of the epigenetic mechanisms that regulate gene transcription. ..
- Onifer S, Quintero J, Gerhardt G. Cutaneous and electrically evoked glutamate signaling in the adult rat somatosensory system. J Neurosci Methods. 2012;208:146-54 pubmed publisher..With the use of MEAs, these results show, for the first time, somatosensory-pathway specific changes in glutamate levels during peripheral cutaneous and electrical stimulation. ..
- Umino Y, Solessio E. Loss of scotopic contrast sensitivity in the optomotor response of diabetic mice. Invest Ophthalmol Vis Sci. 2013;54:1536-43 pubmed publisher..Ins2(Akita/+) mice exhibit a uniform loss in optomotor contrast sensitivity to all spatial frequencies that, unexpectedly, can be explained as being secondary to a retinal or central loss in sensitivity to high temporal frequencies. ..
- Montgomery S, Narrow W, Mastrangelo M, Olschowka J, O Banion M, Bowers W. Chronic neuron- and age-selective down-regulation of TNF receptor expression in triple-transgenic Alzheimer disease mice leads to significant modulation of amyloid- and Tau-related pathologies. Am J Pathol. 2013;182:2285-97 pubmed publisher..In aggregate, these data further support the development of cell-, stage-, and/or receptor-specific anti-TNF-? therapeutics for AD. ..
- Badke M, Pyle G, Shea T, Miedaner J. Outcomes in vestibular ablative procedures. Otol Neurotol. 2002;23:504-9 pubmed..Preoperative vestibular SOT score is highly associated with the emotional, physical, and functional domains of perceived handicap and quality of life after the surgery. ..
- Bell D, Van Zant G. Stem cells, aging, and cancer: inevitabilities and outcomes. Oncogene. 2004;23:7290-6 pubmed
- Keil A, Freund A. Changes in the sensitivity to appetitive and aversive arousal across adulthood. Psychol Aging. 2009;24:668-80 pubmed publisher..e., the relationship between displeasure and arousal). These results extend previous work on emotional development, adding information as to the role of emotional intensity for affective experience in different age groups. ..
- Travison T, Shackelton R, Araujo A, Morley J, Williams R, Clark R, et al. Frailty, serum androgens, and the CAG repeat polymorphism: results from the Massachusetts Male Aging Study. J Clin Endocrinol Metab. 2010;95:2746-54 pubmed publisher..Longitudinal analyses are needed to confirm these conclusions. ..
- Burns J, Cronk B, Anderson H, Donnelly J, Thomas G, Harsha A, et al. Cardiorespiratory fitness and brain atrophy in early Alzheimer disease. Neurology. 2008;71:210-6 pubmed publisher..Cardiorespiratory fitness may moderate AD-related brain atrophy or a common underlying AD-related process may impact both brain atrophy and cardiorespiratory fitness. ..
- Jiang L, Fang J, Moore D, Gogichaeva N, Galeva N, Michaelis M, et al. Age-associated changes in synaptic lipid raft proteins revealed by two-dimensional fluorescence difference gel electrophoresis. Neurobiol Aging. 2010;31:2146-59 pubmed publisher..Differential levels of representative identified proteins were confirmed by immunoblot analysis. Our findings provide novel pathways in investigations of mechanisms that may contribute to altered neuronal function in aging brain. ..
- Blagosklonny M. Hormesis does not make sense except in the light of TOR-driven aging. Aging (Albany NY). 2011;3:1051-62 pubmed..Hormesis B includes ischemic preconditioning and, in part, physical exercise, heat shock, hypoxia and medical interventions. ..
- Lee B, Cho G, Norgren R, Junier M, Hill D, Tapia V, et al. TTF-1, a homeodomain gene required for diencephalic morphogenesis, is postnatally expressed in the neuroendocrine brain in a developmentally regulated and cell-specific fashion. Mol Cell Neurosci. 2001;17:107-26 pubmed
- Zabka A, Behan M, Mitchell G. Selected contribution: Time-dependent hypoxic respiratory responses in female rats are influenced by age and by the estrus cycle. J Appl Physiol (1985). 2001;91:2831-8 pubmed..05), whereas XII LTF increased in middle-aged female rats during diestrus only. Age and gender influence time-dependent hypoxic phrenic and XII responses in a complex manner...
- Spicer S, Schulte B. Pathologic changes of presbycusis begin in secondary processes and spread to primary processes of strial marginal cells. Hear Res. 2005;205:225-40 pubmed..The reduced ATP level may cause cytotoxic alteration of the cytosolic Na(+)/K(+) ratio first in MC secondary processes and later in the primaries, with consequent degeneration of these structures...
- Deane R, Sagare A, Hamm K, Parisi M, LaRue B, Guo H, et al. IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. J Neurosci. 2005;25:11495-503 pubmed..Our data suggest that the FcRn pathway at the BBB plays a crucial role in IgG-assisted Abeta removal from the aging brain. ..
- de la Torre J. Alzheimer's disease prevalence can be lowered with non-invasive testing. J Alzheimers Dis. 2008;14:353-9 pubmed..This clinical approach may have an important impact in reducing the number of new AD and VaD cases and lessen the catastrophic socio-economic burden these dementias are expected to have on the US healthcare system in the near future. ..
- Stanley E, Fadel J. Aging-related deficits in orexin/hypocretin modulation of the septohippocampal cholinergic system. Synapse. 2012;66:445-52 pubmed publisher..Alterations in orexin regulation of septohippocampal cholinergic activity may contribute to age-related dysfunctions in arousal, learning, and memory. ..
- Blagosklonny M. Answering the ultimate question "what is the proximal cause of aging?". Aging (Albany NY). 2012;4:861-77 pubmed..I discuss that these arguments actually support a new theory. Are any questions remaining? And might accumulation of molecular damage still play a peculiar role in aging? ..
- Ramsaran A, Westbrook S, Stanton M. Ontogeny of object-in-context recognition in the rat. Behav Brain Res. 2016;298:37-47 pubmed publisher..e., distal spatial cues) in the OiC task is not equivalent to that of their older counterparts. Implications for the development of contextual memory and its related neural substrates are discussed. ..
- Thomas H, Thurston R. A biopsychosocial approach to women's sexual function and dysfunction at midlife: A narrative review. Maturitas. 2016;87:49-60 pubmed publisher..Overall, holistic, biopsychosocial approaches to women's sexual function are necessary to fully understand and treat this key component of midlife women's well-being. ..
- Dong J, Pinto J, Guo X, Alonso A, TRANAH G, Cauley J, et al. The Prevalence of Anosmia and Associated Factors Among U.S. Black and White Older Adults. J Gerontol A Biol Sci Med Sci. 2017;72:1080-1086 pubmed publisher..Anosmia is common in older adults, particularly among blacks. Further studies are needed to identify risk factors for anosmia and to investigate racial disparities in this sensory deficit. ..
- Chen J, Flannery J, LaVail M, Steinberg R, Xu J, Simon M. bcl-2 overexpression reduces apoptotic photoreceptor cell death in three different retinal degenerations. Proc Natl Acad Sci U S A. 1996;93:7042-7 pubmed..Apoptosis was induced in normal photoreceptors by very high levels of bcl-2. We conclude that bcl-2 is an important regulator of photoreceptor cell death in retinal degenerations. ..
- Dhahbi J, Mote P, Wingo J, Rowley B, Cao S, Walford R, et al. Caloric restriction alters the feeding response of key metabolic enzyme genes. Mech Ageing Dev. 2001;122:1033-48 pubmed..The data are consistent with the idea that CR continuously promotes the turnover and replacement of extrahepatic proteins. ..
- Sadoun E, Reed M. Impaired angiogenesis in aging is associated with alterations in vessel density, matrix composition, inflammatory response, and growth factor expression. J Histochem Cytochem. 2003;51:1119-30 pubmed..6 x 10(3) +/- 7.3 x 10(3)) to 19d (34.9 x 10(3) +/- 17 x 10(3)). We conclude that angiogenesis in aging is not merely delayed, but is altered due to multiple impairments. ..
- Ambati J, Anand A, Fernandez S, Sakurai E, Lynn B, Kuziel W, et al. An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice. Nat Med. 2003;9:1390-7 pubmed..These models implicate macrophage dysfunction in AMD pathogenesis and may be useful as a platform for validating therapies. ..
- Getchell T, Peng X, Green C, Stromberg A, Chen K, Mattson M, et al. In silico analysis of gene expression profiles in the olfactory mucosae of aging senescence-accelerated mice. J Neurosci Res. 2004;77:430-52 pubmed
- Chelvarajan R, Collins S, Van Willigen J, Bondada S. The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function. J Leukoc Biol. 2005;77:503-12 pubmed..As aged MPhi have a reduced number of cells expressing Toll-like receptor 4 and CD14, the imbalance in cytokine production might be partly a result of fewer cells expressing key components of the LPS receptor complex. ..