Experts and Doctors on aging in Finland


Locale: Finland
Topic: aging

Top Publications

  1. Ahtiainen J, Walker S, Peltonen H, Holviala J, Sillanpää E, Karavirta L, et al. Heterogeneity in resistance training-induced muscle strength and mass responses in men and women of different ages. Age (Dordr). 2016;38:10 pubmed publisher
    ..Whether these changes are associated with, e.g., functional capacity and metabolic health improvements due to RT requires further studies. ..
  2. Salomaa V, Havulinna A, Koukkunen H, Kärjä Koskenkari P, Pietilä A, Mustonen J, et al. Aging of the population may not lead to an increase in the numbers of acute coronary events: a community surveillance study and modelled forecast of the future. Heart. 2013;99:954-9 pubmed publisher
    ..The ACS event rates and absolute numbers of cases have declined steeply in Finland. The declining trends are likely to continue in the future despite the aging of the population. ..
  3. Laine T, Lyytikäinen T, Yliaho M, Anttila M. Risk factors for post-weaning diarrhoea on piglet producing farms in Finland. Acta Vet Scand. 2008;50:21 pubmed publisher
    ..With increasing number of sows in the herds the risk of PWD increases and more attention should be paid to prevention of post-weaning diarrhoea. ..
  4. Koskinen E, Andersson M, Katila T. Effect of 19-norandrostenololylaurate on testicular growth in colts. Acta Vet Scand. 1997;38:51-7 pubmed
    ..Growth similar to that in control animals started after a delay of 4-5 months. TW in treated animals nearly reached TW in controls within 12 months of cessation of treatment. ..
  5. Salminen A, Kaarniranta K. Insulin/IGF-1 paradox of aging: regulation via AKT/IKK/NF-kappaB signaling. Cell Signal. 2010;22:573-7 pubmed publisher
    ..We will discuss the evidence that insulin/IGF-1 signaling can enhance the NF-kappaB signaling and subsequently potentiate the aging process and aggravate age-related degenerative diseases. ..
  6. Andressoo J, Hoeijmakers J, Mitchell J. Nucleotide excision repair disorders and the balance between cancer and aging. Cell Cycle. 2006;5:2886-8 pubmed
    ..In this review, we will discuss the connection between genome maintenance, aging and cancer in light of a new mouse model of XPD disease. ..
  7. Piltonen T, Koivunen R, Ruokonen A, Tapanainen J. Ovarian age-related responsiveness to human chorionic gonadotropin. J Clin Endocrinol Metab. 2003;88:3327-32 pubmed
    ..Despite that, circulating E(2) levels remain normal for years, possibly due to compensatory mechanisms, reflected by the gradual rise in serum FSH levels. ..
  8. Pöllänen E, Sipila S, Alen M, Ronkainen P, Ankarberg Lindgren C, Puolakka J, et al. Differential influence of peripheral and systemic sex steroids on skeletal muscle quality in pre- and postmenopausal women. Aging Cell. 2011;10:650-60 pubmed publisher
    ..We conclude that systemically delivered and peripherally produced sex steroids have distinct roles in the regulation of neuromuscular characteristics during aging. ..
  9. Kaasinen V, Vilkman H, Hietala J, NAgren K, Helenius H, Olsson H, et al. Age-related dopamine D2/D3 receptor loss in extrastriatal regions of the human brain. Neurobiol Aging. 2000;21:683-8 pubmed
    ..Further, the rate of D2/3R decline may be faster in the frontal cortex as compared to the temporal and thalamic regions. ..

More Information


  1. Tiihonen K, Ouwehand A, Rautonen N. Human intestinal microbiota and healthy ageing. Ageing Res Rev. 2010;9:107-16 pubmed publisher
    ..This mini-review will focus on the recent findings on the gut microbiota of the elderly and on the potential benefits of probiotics, prebiotics and synbiotics. ..
  2. Mutikainen S, Rantanen T, Alen M, Kauppinen M, Karjalainen J, Ortega Alonso A, et al. Electrocardiographic and other clinical correlates of walking ability in older women. Arch Gerontol Geriatr. 2010;51:216-21 pubmed publisher
    ..Resting ECG does not give clinically significant additional information for the assessment in subjects without overt cardiac disease. ..
  3. Zhao C, Puurunen K, Schallert T, Sivenius J, Jolkkonen J. Behavioral effects of photothrombotic ischemic cortical injury in aged rats treated with the sedative-hypnotic GABAergic drug zopiclone. Behav Brain Res. 2005;160:260-6 pubmed
    ..In conclusion, zopiclone was not detrimental and even seemed to improve behavioral outcome without affecting ischemic damage in aged rats subjected to cortical photothrombosis. ..
  4. Overmyer M, Helisalmi S, Soininen H, Laakso M, Riekkinen P, Alafuzoff I. Reactive microglia in aging and dementia: an immunohistochemical study of postmortem human brain tissue. Acta Neuropathol. 1999;97:383-92 pubmed
  5. Salminen A, Kaarniranta K. Control of p53 and NF-?B signaling by WIP1 and MIF: role in cellular senescence and organismal aging. Cell Signal. 2011;23:747-52 pubmed publisher
    ..We will review the findings linking WIP1 and MIF to specific signaling responses of p53 and NF-?B and discuss their role in the regulation of cellular senescence and organismal aging. ..
  6. Salminen A, Kaarniranta K. Regulation of the aging process by autophagy. Trends Mol Med. 2009;15:217-24 pubmed publisher
    ..We discuss the possibility that these well-known stress resistance and longevity factors regulate the aging process via autophagy. ..
  7. Tiainen K, Luukkaala T, Hervonen A, Jylha M. Predictors of mortality in men and women aged 90 and older: a nine-year follow-up study in the Vitality 90+ study. Age Ageing. 2013;42:468-75 pubmed publisher
    ..Disability increases the likelihood of death more in men than women. At a very old age, women survive longer with moderate disability than do men. ..
  8. Salminen A, Kaarniranta K, Kauppinen A. Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: impact on the aging process. Ageing Res Rev. 2013;12:520-34 pubmed publisher
    ..We will review the role of Beclin 1 interactome in the crosstalk between apoptosis, autophagy and inflammasomes emphasizing that disturbances in Beclin 1-dependent autophagy can have a crucial impact on the aging process. ..
  9. Wigren H, Rytkönen K, Porkka Heiskanen T. Basal forebrain lactate release and promotion of cortical arousal during prolonged waking is attenuated in aging. J Neurosci. 2009;29:11698-707 pubmed publisher
    ..As the quality of waking is important in regulating the subsequent sleep, reduced cortical arousal during SD may contribute to the age-related reduction in sleep intensity. ..
  10. Järvelä J, Lopez Picon F, Plysjuk A, Ruohonen S, Holopainen I. Temporal profiles of age-dependent changes in cytokine mRNA expression and glial cell activation after status epilepticus in postnatal rat hippocampus. J Neuroinflammation. 2011;8:29 pubmed publisher
  11. Kalesnykas G, Roschier U, Puoliväli J, Wang J, Miettinen R. The effect of aging on the subcellular distribution of estrogen receptor-alpha in the cholinergic neurons of transgenic and wild-type mice. Eur J Neurosci. 2005;21:1437-42 pubmed
    ..We propose that this phenomenon is linked to those age-related processes known to be involved in inhibiting ERalpha binding to nuclei. ..
  12. Tuohimaa P. Vitamin D and aging. J Steroid Biochem Mol Biol. 2009;114:78-84 pubmed
  13. Pohjasvaara T, Erkinjuntti T, Vataja R, Kaste M. Dementia three months after stroke. Baseline frequency and effect of different definitions of dementia in the Helsinki Stroke Aging Memory Study (SAM) cohort. Stroke. 1997;28:785-92 pubmed
  14. Vilo S, Rautiainen P, Kaisti K, Aantaa R, Scheinin M, Manner T, et al. Pharmacokinetics of intravenous dexmedetomidine in children under 11 yr of age. Br J Anaesth. 2008;100:697-700 pubmed publisher
    ..Since the total plasma clearance of dexmedetomidine is independent of age, similar rates of infusion can be used in younger and older children to maintain a steady-state concentration of dexmedetomidine in plasma. ..
  15. Korhonen M, Cristea A, Alen M, HAkkinen K, Sipila S, Mero A, et al. Aging, muscle fiber type, and contractile function in sprint-trained athletes. J Appl Physiol (1985). 2006;101:906-17 pubmed
    ..However, the muscle characteristics were preserved at a high level in the oldest runners, underlining the favorable impact of sprint exercise on aging muscle. ..
  16. Gienapp P, Merilä J. Genetic and environmental effects on a condition-dependent trait: feather growth in Siberian jays. J Evol Biol. 2010;23:715-23 pubmed publisher
    ..Consequently, variation in feather growth rates as assessed with ptilochronological methods can provide information about heritable genetic differences in condition. ..
  17. Eerola J, Kananen L, Manninen K, Hellstrom O, Tienari P, Hovatta I. No evidence for shorter leukocyte telomere length in Parkinson's disease patients. J Gerontol A Biol Sci Med Sci. 2010;65:1181-4 pubmed publisher
    ..54). Furthermore, extremely short telomeres were not more frequent in PD patients than in controls, as suggested in an earlier study. Our results do not support the concept of accelerated leukocyte telomere shortening in PD. ..
  18. Perheentupa J. Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J Clin Endocrinol Metab. 2006;91:2843-50 pubmed
    ..Any child or young adult with one of the many disease components should be examined for others and consideration of AIRE mutation assay. ..
  19. von Bonsdorff M, Rantanen T, Törmäkangas T, Kulmala J, Hinrichs T, Seitsamo J, et al. Midlife work ability and mobility limitation in old age among non-disability and disability retirees--a prospective study. BMC Public Health. 2016;16:154 pubmed publisher
    ..Promoting work ability in midlife may lead to more independent, active aging, regardless of type of retirement. ..
  20. Sanz A, Stefanatos R. The mitochondrial free radical theory of aging: a critical view. Curr Aging Sci. 2008;1:10-21 pubmed
    ..g. insulin signalling). If MFRTA is true animals producing fewer mtROS must have the ability to live much longer than their experimental controls. ..
  21. Nummela O, Sulander T, Helakorpi S, Haapola I, Uutela A, Heinonen H, et al. Register-based data indicated nonparticipation bias in a health study among aging people. J Clin Epidemiol. 2011;64:1418-25 pubmed publisher
    ..In particular, health inequalities by gender and income differed between respondents and nonrespondents. Thus, nonresponse may lead to bias in analyses of health inequalities among aging people. ..
  22. Laukkarinen J, Kiudelis G, Lempinen M, Raty S, Pelli H, Sand J, et al. Increased prevalence of subclinical hypothyroidism in common bile duct stone patients. J Clin Endocrinol Metab. 2007;92:4260-4 pubmed
    ..At minimum, women older than 60 yr with CBD stones should be screened for borderline or overt subclinical hypothyroidism. ..
  23. Saransaari P, Oja S. Phencyclidine-binding sites in mouse cerebral cortex during development and ageing: effects of inhibitory amino acids. Mech Ageing Dev. 1993;68:125-36 pubmed
  24. Tolppanen A, Ngandu T, Kåreholt I, Laatikainen T, Rusanen M, Soininen H, et al. Midlife and late-life body mass index and late-life dementia: results from a prospective population-based cohort. J Alzheimers Dis. 2014;38:201-9 pubmed publisher
    ..Steeper decrease of BMI and low late-life BMI are associated with higher risk of dementia and AD. These findings highlight the importance of life-course perspective when assessing the association between BMI and cognition. ..
  25. Sallert M, Malkki H, Segerstrale M, Taira T, Lauri S. Effects of the kainate receptor agonist ATPA on glutamatergic synaptic transmission and plasticity during early postnatal development. Neuropharmacology. 2007;52:1354-65 pubmed
    ..These data show that GluR5 signaling mechanisms are developmentally regulated and suggest distinct functional role for KARs in the modulation of synaptic transmission and plasticity at different stages of development. ..
  26. Suorsa A, Hietala O, Pajunen A. Developmental expression of ornithine and S-adenosylmethionine decarboxylases in mouse brain. Biochem Biophys Res Commun. 1992;184:1114-8 pubmed
    ..These data suggest the development-dependent appearance of post-transcriptional regulation mechanisms. ..
  27. Parkkinen L, Soininen H, Alafuzoff I. Regional distribution of alpha-synuclein pathology in unimpaired aging and Alzheimer disease. J Neuropathol Exp Neurol. 2003;62:363-7 pubmed
    ..However, this was not inevitably associated with AD pathology, but was related to cognitive decline. Incidental LBs in the SN were described in the occasional subjects, with no alphaS pathology in the lower brainstem. ..
  28. Jylhävä J, Eklund C, Jylha M, Hervonen A, Lehtimaki T, Karhunen P, et al. Complement factor H 402His variant confers an increased mortality risk in Finnish nonagenarians: the Vitality 90+ study. Exp Gerontol. 2009;44:297-9 pubmed publisher
    ..016). We propose that the increased mortality is inflammation-related and mediated by aberrant complement regulation by the CFH 402His variant. ..
  29. Sanz A, Soikkeli M, Portero Otin M, Wilson A, Kemppainen E, McIlroy G, et al. Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction. Proc Natl Acad Sci U S A. 2010;107:9105-10 pubmed publisher
    ..Our results support a central role of mitochondrial oxidative phosphorylation complex I in influencing longevity via oxidative stress, independently of pathways connected to nutrition and growth signaling. ..
  30. Niemelä K, Leinonen R, Laukkanen P. The effect of geriatric rehabilitation on physical performance and pain in men and women. Arch Gerontol Geriatr. 2011;52:e129-33 pubmed publisher
    ..The differences between the sexes in the experience of pain, disease symptoms and in the knee extension strength could provide a new perspective in the planning of more individual rehabilitation interventions. ..
  31. Björklund M, Ouwehand A, Forssten S, Nikkilä J, Tiihonen K, Rautonen N, et al. Gut microbiota of healthy elderly NSAID users is selectively modified with the administration of Lactobacillus acidophilus NCFM and lactitol. Age (Dordr). 2012;34:987-99 pubmed publisher
    ..In conclusion, putatively beneficial changes in microbiota were observed in the elderly subjects supplemented with the synbiotic product...
  32. Tuominen L, Salo J, Hirvonen J, Någren K, Laine P, Melartin T, et al. Temperament trait Harm Avoidance associates with ?-opioid receptor availability in frontal cortex: a PET study using [(11)C]carfentanil. Neuroimage. 2012;61:670-6 pubmed publisher
    ..The results have relevance in the research of vulnerability factors for affective disorders. ..
  33. Scialò F, Sriram A, Fernández Ayala D, Gubina N, Lõhmus M, Nelson G, et al. Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan. Cell Metab. 2016;23:725-34 pubmed publisher
    ..These results illustrate that the source of a ROS signal is vital in determining its effects on cellular physiology and establish that manipulation of ubiquinone redox state is a valid strategy to delay aging. ..
  34. Iivanainen A, Sainio K, Sariola H, Tryggvason K. Primary structure and expression of a novel human laminin alpha 4 chain. FEBS Lett. 1995;365:183-8 pubmed
    ..In situ hybridization analysis of human fetal and newborn tissues showed expression of the laminin in alpha 4 chain in certain mesenchymal cells in tissues such as smooth muscle and dermis. ..
  35. Riekkinen P, Schmidt B, Stefanski R, Kuitunen J, Riekkinen M. Metrifonate improves spatial navigation and avoidance behavior in scopolamine-treated, medial septum-lesioned and aged rats. Eur J Pharmacol. 1996;309:121-30 pubmed
    ..These results show that metrifonate may over a wide range of doses stimulate cognitive functioning, but during advanced aging neurobiological defects develop that may mask some of the therapeutic effects of metrifonate in rats. ..
  36. Ihanamäki T, Säämänen A, Suominen J, Pelliniemi L, Harley V, Vuorio E, et al. Expression of Sox9 and type IIA procollagen during ocular development and aging in transgenic Del1 mice with a mutation in the type II collagen gene. Eur J Ophthalmol. 2002;12:450-8 pubmed
  37. Minkeviciene R, Ihalainen J, Malm T, Matilainen O, Keksa Goldsteine V, Goldsteins G, et al. Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice. J Neurochem. 2008;105:584-94 pubmed
    ..Astrocyte activation as measured by glial acidic fibrillary protein was increased in middle-aged APdE9 mice. Blunted pre-synaptic glutamate response may contribute to memory deficit in middle-aged APdE9 mice. ..
  38. Reponen P, Sahlberg C, Huhtala P, Hurskainen T, Thesleff I, Tryggvason K. Molecular cloning of murine 72-kDa type IV collagenase and its expression during mouse development. J Biol Chem. 1992;267:7856-62 pubmed
    ..The mouse cDNA clones reported in this study may provide important tools unraveling the actual roles of these enzymes in vivo. ..
  39. Merenmies J, Rauvala H. Molecular cloning of the 18-kDa growth-associated protein of developing brain. J Biol Chem. 1990;265:16721-4 pubmed
  40. Liakka K. The integrin subunits alpha 2, alpha 3, alpha 4, alpha 5, alpha 6, alpha V, beta 1 and beta 3 in fetal, infant and adult human spleen as detected by immunohistochemistry. Differentiation. 1994;56:183-90 pubmed
    ..abstract truncated at 250 words)..
  41. Aro H, Alm J, Moritz N, Makinen T, Lankinen P. Low BMD affects initial stability and delays stem osseointegration in cementless total hip arthroplasty in women: a 2-year RSA study of 39 patients. Acta Orthop. 2012;83:107-14 pubmed publisher
    ..We compared migration of hydroxyapatite-coated femoral stems in women with or without low systemic BMD...
  42. Stenholm S, Tiainen K, Rantanen T, Sainio P, Heliovaara M, Impivaara O, et al. Long-term determinants of muscle strength decline: prospective evidence from the 22-year mini-Finland follow-up survey. J Am Geriatr Soc. 2012;60:77-85 pubmed publisher
    ..Efforts should be made to recognize persons at risk in a timely manner and target early interventions to middle-aged persons to slow down muscle strength decline and prevent future functional limitations and disability. ..
  43. Jaatinen R, Laitinen M, Vuojolainen K, Aaltonen J, Louhio H, Heikinheimo K, et al. Localization of growth differentiation factor-9 (GDF-9) mRNA and protein in rat ovaries and cDNA cloning of rat GDF-9 and its novel homolog GDF-9B. Mol Cell Endocrinol. 1999;156:189-93 pubmed
  44. Nummela O, Seppänen M, Uutela A. The effect of loneliness and change in loneliness on self-rated health (SRH): a longitudinal study among aging people. Arch Gerontol Geriatr. 2011;53:163-7 pubmed publisher
    ..In addition, favorable SRH is indicated not only by the absence of loneliness at both measurement points, but also by decreased loneliness. Preventing loneliness is important for health promotion. ..
  45. Rantone T, Grönlund J, Jalonen J, Ekblad U, Kääpä P, Kero P, et al. Comparison of the effects of antenatal magnesium sulphate and ritodrine exposure on circulatory adaptation in preterm infants. Clin Physiol Funct Imaging. 2002;22:13-7 pubmed
    ..This early vascular stabilizing effect of antenatal MgSO4 exposure may contribute to a lowered risk of cerebral vascular catastrophes, in the vulnerable areas of the brain, among the preterm infants with respiratory distress syndrome...
  46. Sanz A, Fernandez Ayala D, Stefanatos R, Jacobs H. Mitochondrial ROS production correlates with, but does not directly regulate lifespan in Drosophila. Aging (Albany NY). 2010;2:200-23 pubmed
    ..In summary, these results do not systematically support the predictions of the MFRTA. Accordingly, MFRTA should be revised to accommodate these findings. ..
  47. Siitari H, Alatalo R, Halme P, Buchanan K, Kilpimaa J. Color signals in the black grouse (Tetrao tetrix): signal properties and their condition dependency. Am Nat. 2007;169 Suppl 1:S81-92 pubmed publisher
  48. Korolainen M, Auriola S, Nyman T, Alafuzoff I, Pirttila T. Proteomic analysis of glial fibrillary acidic protein in Alzheimer's disease and aging brain. Neurobiol Dis. 2005;20:858-70 pubmed
    ..Mechanisms, structures and functional consequences of modification of GFAP isoforms remain to be clarified. ..
  49. Huuskonen A, Khalili H, Kiljala J, Joki Tokola E, Nousiainen J. Effects of vegetable fats versus lard in milk replacers on feed intake, digestibility, and growth in Finnish Ayrshire bull calves. J Dairy Sci. 2005;88:3575-81 pubmed
  50. Mologni L, Moza M, Lalowski M, Carpen O. Characterization of mouse myotilin and its promoter. Biochem Biophys Res Commun. 2005;329:1001-9 pubmed
    ..Finally, endogenous myotilin is induced at later stages of Z-disc assembly in C(2)C(12) cells indicating conservation between mouse and human promoter region. ..
  51. Pertovaara M, Raitala A, Lehtimaki T, Karhunen P, Oja S, Jylha M, et al. Indoleamine 2,3-dioxygenase activity in nonagenarians is markedly increased and predicts mortality. Mech Ageing Dev. 2006;127:497-9 pubmed
    ..Thus, increased IDO activity might be a mechanism involved in the decline of T cell responses in immunosenescence. ..
  52. Maatta J, Buki K, Gu G, Alanne M, Vääräniemi J, Liljenbäck H, et al. Inactivation of estrogen receptor ? in bone-forming cells induces bone loss in female mice. FASEB J. 2013;27:478-88 pubmed publisher ..
  53. Strandberg T, Pitkala K, Tilvis R, O Neill D, Erkinjuntti T. Geriatric syndromes--vascular disorders?. Ann Med. 2013;45:265-73 pubmed publisher
    ..Further disentangling of the mechanisms of vascular ageing may offer therapies for vascular diseases and geriatric syndromes alike...
  54. Akinola L, Poutanen M, Vihko R, Vihko P. Expression of 17beta-hydroxysteroid dehydrogenase type 1 and type 2, P450 aromatase, and 20alpha-hydroxysteroid dehydrogenase enzymes in immature, mature, and pregnant rats. Endocrinology. 1997;138:2886-92 pubmed
    ..The relatively constitutive expression of the enzyme at all physiological stages of the animals suggests a general role for the enzyme in the inactivation of circulating sex steroids. ..
  55. Karlstedt K, Ahman M, Anichtchik O, Soinila S, Panula P. Expression of the H3 receptor in the developing CNS and brown fat suggests novel roles for histamine. Mol Cell Neurosci. 2003;24:614-22 pubmed
  56. Rantakokko J, Aro H, Savontaus M, Vuorio E. Mouse cathepsin K: cDNA cloning and predominant expression of the gene in osteoclasts, and in some hypertrophying chondrocytes during mouse development. FEBS Lett. 1996;393:307-13 pubmed
    ..Association of cathepsin K production with degradation of bone and cartilage matrix suggests that this enzyme and its mRNA levels could serve as markers for matrix degradation in diseases affecting these tissues. ..
  57. Joronen K, Salminen H, Glumoff V, Savontaus M, Vuorio E. Temporospatial expression of tissue inhibitors of matrix metalloproteinases-1, -2 and -3 during development, growth and aging of the mouse skeleton. Histochem Cell Biol. 2000;114:157-65 pubmed
    ..These findings suggest that the capacity of articular cartilage chondrocytes to inhibit MMP activities by local production of TIMPs is limited, which may be of consequence during osteoarthritic cartilage degeneration. ..
  58. Bjorklund M, Siverina I, Heikkinen T, Tanila H, Sallinen J, Scheinin M, et al. Spatial working memory improvement by an alpha2-adrenoceptor agonist dexmedetomidine is not mediated through alpha2C-adrenoceptor. Prog Neuropsychopharmacol Biol Psychiatry. 2001;25:1539-54 pubmed
    ..Further, this study confirms our earlier finding that the presence of alpha2C-adrenoceptors is not necessary for the spatial working memory enhancing effect of alpha2-adrenoceptor agonists. ..
  59. Hyttinen M, Arokoski J, Parkkinen J, Lammi M, Lapveteläinen T, Mauranen K, et al. Age matters: collagen birefringence of superficial articular cartilage is increased in young guinea-pigs but decreased in older animals after identical physiological type of joint loading. Osteoarthritis Cartilage. 2001;9:694-701 pubmed
    ..It can be hypothesized further that with time the inferior property of the collagen network predisposes the older runners to earlier OA than in controls. ..
  60. Louhija J, Miettinen H, Kontula K, Tikkanen M, Miettinen T, Tilvis R. Aging and genetic variation of plasma apolipoproteins. Relative loss of the apolipoprotein E4 phenotype in centenarians. Arterioscler Thromb. 1994;14:1084-9 pubmed
    ..24 versus 3.43 mmol/L; P < .05).(ABSTRACT TRUNCATED AT 250 WORDS) ..
  61. Salminen A, Kauppinen A, Suuronen T, Kaarniranta K. SIRT1 longevity factor suppresses NF-kappaB -driven immune responses: regulation of aging via NF-kappaB acetylation?. Bioessays. 2008;30:939-42 pubmed publisher
    ..Longevity factors, such as SIRT1 and its activators, might regulate the efficiency of the NF-kappaB signaling, the major outcome of which is inflamm-aging via proinflammatory responses. ..
  62. Jalava N, Lopez Picon F, Kukko Lukjanov T, Holopainen I. Changes in microtubule-associated protein-2 (MAP2) expression during development and after status epilepticus in the immature rat hippocampus. Int J Dev Neurosci. 2007;25:121-31 pubmed
    ..Moreover, high-molecular weight MAP2s may play a role in nerve cell survival during cell stress. ..
  63. Alakärppä K, Tupala E, Mantere T, Särkioja T, Rasanen P, Tarhanen J, et al. Effect of alcohol abuse on human brain histamine and tele-methylhistamine. Inflamm Res. 2002;51 Suppl 1:S40-1 pubmed
  64. Leinonen M, Nieminen P, Kotaniemi Talonen L, Malila N, Tarkkanen J, Laurila P, et al. Age-specific evaluation of primary human papillomavirus screening vs conventional cytology in a randomized setting. J Natl Cancer Inst. 2009;101:1612-23 pubmed publisher
    ..Among women aged 35 years or older, primary HPV DNA screening with cytology triage is also more specific than conventional screening and decreases colposcopy referrals and follow-up tests. ..
  65. Salminen A, Suuronen T, Huuskonen J, Kaarniranta K. NEMO shuttle: a link between DNA damage and NF-kappaB activation in progeroid syndromes?. Biochem Biophys Res Commun. 2008;367:715-8 pubmed publisher
    ..The NEMO shuttle may link genotoxic stress to the activation of the innate immunity system and cause premature aging via inflamm-aging process. ..
  66. Hamalainen T, Poutanen M, Huhtaniemi I. Age- and sex-specific promoter function of a 2-kilobase 5'-flanking sequence of the murine luteinizing hormone receptor gene in transgenic mice. Endocrinology. 1999;140:5322-9 pubmed
  67. Panhelainen A, Korpi E. Evidence for a role of inhibition of orexinergic neurons in the anxiolytic and sedative effects of diazepam: A c-Fos study. Pharmacol Biochem Behav. 2012;101:115-24 pubmed publisher
    ..On the other hand, the ventral hippocampus, basolateral amygdala, ventral tegmental area and prefrontal cortex were sensitive even to the mild injection stress, but not to the anxiolytic dose of DZ. ..
  68. von Bonsdorff M, Huuhtanen P, Tuomi K, Seitsamo J. Predictors of employees' early retirement intentions: an 11-year longitudinal study. Occup Med (Lond). 2010;60:94-100 pubmed publisher
    ..In addition, negative perceptions about work predicted early retirement intentions among men. Adverse work- or health-related factors detected in middle age predicted subsequent early retirement intentions. ..
  69. Rossi J, Tomac A, Saarma M, Airaksinen M. Distinct roles for GFRalpha1 and GFRalpha2 signalling in different cranial parasympathetic ganglia in vivo. Eur J Neurosci. 2000;12:3944-52 pubmed
    ..These results indicate that GDNF and NRTN have distinct functions in developing parasympathetic neurons, and suggest heterogeneity among and within different parasympathetic ganglia. ..
  70. Rasi K, Piuhola J, Czabanka M, Sormunen R, Ilves M, Leskinen H, et al. Collagen XV is necessary for modeling of the extracellular matrix and its deficiency predisposes to cardiomyopathy. Circ Res. 2010;107:1241-52 pubmed publisher
    ..Collagen (Col) XV is preferentially expressed in the ECM of cardiac muscle and microvessels...
  71. Kopra O, Vesa J, von Schantz C, Manninen T, Minye H, Fabritius A, et al. A mouse model for Finnish variant late infantile neuronal ceroid lipofuscinosis, CLN5, reveals neuropathology associated with early aging. Hum Mol Genet. 2004;13:2893-906 pubmed
    ..Since the Cln5-/- mice do not exhibit significant brain atrophy, these mice could serve as models for studies on molecular processes associated with advanced aging. ..
  72. Jolanki O. Moral argumentation in talk about health and old age. Health (London). 2004;8:483-503 pubmed
    ..Finally, the results are discussed in relation to cultural discourses of old age and health, and their moral implications. ..
  73. Härkönen K, Huhtaniemi I, Mäkinen J, Hübler D, Irjala K, Koskenvuo M, et al. The polymorphic androgen receptor gene CAG repeat, pituitary-testicular function and andropausal symptoms in ageing men. Int J Androl. 2003;26:187-94 pubmed