Experts and Doctors on active biological transport in Switzerland


Locale: Switzerland
Topic: active biological transport

Top Publications

  1. Roch Ramel F. Renal transport of organic anions. Curr Opin Nephrol Hypertens. 1998;7:517-24 pubmed
    ..Other apical transport mechanisms, sodium coupled transports and anion exchangers are involved in organic anion reabsorption. ..
  2. Frangne N, Eggmann T, Koblischke C, Weissenböck G, Martinoia E, Klein M. Flavone glucoside uptake into barley mesophyll and Arabidopsis cell culture vacuoles. Energization occurs by H(+)-antiport and ATP-binding cassette-type mechanisms. Plant Physiol. 2002;128:726-33 pubmed
    ..We propose that different vacuolar transporters may be responsible for the sequestration of species-specific/endogenous and nonspecific/xenobiotic secondary compounds in planta. ..
  3. Capponi A. The control by angiotensin II of cholesterol supply for aldosterone biosynthesis. Mol Cell Endocrinol. 2004;217:113-8 pubmed
  4. Anner B, Moosmayer M. Mercury inhibits Na-K-ATPase primarily at the cytoplasmic side. Am J Physiol. 1992;262:F843-8 pubmed
    ..The results show that the metal-binding interface of Na-K-ATPase molecule is profoundly implicated in active ion transport and that the intracellular part of the Na-K-ATPase molecule presents the primary target for mercury action. ..
  5. Saurer L, McCullough K, Summerfield A. In vitro induction of mucosa-type dendritic cells by all-trans retinoic acid. J Immunol. 2007;179:3504-14 pubmed
    ..Consequently, RA targeting of DC shows potential for promoting vaccine-induced mucosal immune responses via a parenteral route of immunization. ..
  6. Verrey F, Loffing J, Zecevic M, Heitzmann D, Staub O. SGK1: aldosterone-induced relay of Na+ transport regulation in distal kidney nephron cells. Cell Physiol Biochem. 2003;13:21-8 pubmed
  7. Kusch Poddar M, Drewe J, Fux I, Gutmann H. Evaluation of the immortalized human brain capillary endothelial cell line BB19 as a human cell culture model for the blood-brain barrier. Brain Res. 2005;1064:21-31 pubmed
    ..We conclude that BB19 cells might be feasible as a human in vitro model of the BBB for drug uptake studies. However, for the assessment of transport studies, further improvements of this model are necessary. ..
  8. Bogman K, Erne Brand F, Alsenz J, Drewe J. The role of surfactants in the reversal of active transport mediated by multidrug resistance proteins. J Pharm Sci. 2003;92:1250-61 pubmed
    ..The present analysis offers insight in the possible mechanisms of surfactant interactions with biological membranes and could help to identify specific drug formulations. ..
  9. Cosson P, Démollière C, Hennecke S, Duden R, Letourneur F. Delta- and zeta-COP, two coatomer subunits homologous to clathrin-associated proteins, are involved in ER retrieval. EMBO J. 1996;15:1792-8 pubmed
    ..Both proteins show significant homology to clathrin adaptor subunits. These results emphasize the role of coatomer in retrieval of dilysine-tagged proteins back to the ER, and the similarity between clathrin and coatomer coats. ..

More Information


  1. Tsai C, Ziegler C. Coupling electron cryomicroscopy and X-ray crystallography to understand secondary active transport. Curr Opin Struct Biol. 2010;20:448-55 pubmed publisher
    ..In addition, 3D EM maps are better suited to investigate transporter activation because of the lipidic environment. ..
  2. Schramm H. A unique intracellular, extracellular and transmembrane circulation of potassium ions in the auditory inner ear as an anticarcinogenic principle? Part 1. Inflamm Allergy Drug Targets. 2010;9:109-19 pubmed
  3. Loffing J, Flores S, Staub O. Sgk kinases and their role in epithelial transport. Annu Rev Physiol. 2006;68:461-90 pubmed
    ..In this review we first discuss the molecular, cellular, and regulatory aspects of Sgk1 and its paralogs. We then discuss its roles in the physiology and pathophysiology of epithelial ion transport. ..
  4. Geisler M, Blakeslee J, Bouchard R, Lee O, Vincenzetti V, Bandyopadhyay A, et al. Cellular efflux of auxin catalyzed by the Arabidopsis MDR/PGP transporter AtPGP1. Plant J. 2005;44:179-94 pubmed
  5. Nagy R, Karandashov V, Chague V, Kalinkevich K, Tamasloukht M, Xu G, et al. The characterization of novel mycorrhiza-specific phosphate transporters from Lycopersicon esculentum and Solanum tuberosum uncovers functional redundancy in symbiotic phosphate transport in solanaceous species. Plant J. 2005;42:236-50 pubmed publisher
    ..Knock out of LePT4 in the tomato cv. MicroTom indicated considerable redundancy between LePT4 and other Pi transporters in tomato...
  6. Stauber A, Radanovic T, Stange G, Murer H, Wagner C, Biber J. Regulation of intestinal phosphate transport. II. Metabolic acidosis stimulates Na(+)-dependent phosphate absorption and expression of the Na(+)-P(i) cotransporter NaPi-IIb in small intestine. Am J Physiol Gastrointest Liver Physiol. 2005;288:G501-6 pubmed
  7. Molinari M, Eriksson K, Calanca V, Galli C, Cresswell P, Michalak M, et al. Contrasting functions of calreticulin and calnexin in glycoprotein folding and ER quality control. Mol Cell. 2004;13:125-35 pubmed
    ..Although not fully interchangeable during assistance of glycoprotein folding, calreticulin and calnexin may work, independently, as efficient and crucial factors for retention in the ER of nonnative polypeptides. ..
  8. Koehler C, Murphy M, Bally N, Leuenberger D, Oppliger W, Dolfini L, et al. Tim18p, a new subunit of the TIM22 complex that mediates insertion of imported proteins into the yeast mitochondrial inner membrane. Mol Cell Biol. 2000;20:1187-93 pubmed
    ..We suggest that Tim18p functions in the assembly and stabilization of the TIM22 complex but does not directly participate in protein insertion into the inner membrane. ..
  9. Pfeiffer R, Rossier G, Spindler B, Meier C, Kuhn L, Verrey F. Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family. EMBO J. 1999;18:49-57 pubmed
  10. Haucke V, Schatz G. Reconstitution of the protein insertion machinery of the mitochondrial inner membrane. EMBO J. 1997;16:4560-7 pubmed
    ..The protein insertion machinery can thus operate independently of the energy-transducing Tim44p-mhsp70 complex. ..
  11. Pizzagalli F, Varga Z, Huber R, Folkers G, Meier P, St Pierre M. Identification of steroid sulfate transport processes in the human mammary gland. J Clin Endocrinol Metab. 2003;88:3902-12 pubmed
  12. Schlumberger M, Müller A, Ehrbar K, Winnen B, Duss I, Stecher B, et al. Real-time imaging of type III secretion: Salmonella SipA injection into host cells. Proc Natl Acad Sci U S A. 2005;102:12548-53 pubmed
    ..Similar observations were made for the effector protein SopE. This visualization of type III secretion in real time explains the efficiency of host cell manipulation by means of this virulence system. ..
  13. Theisinger A, Grenacher B, Scharrer E. Na+ gradient-dependent transport of hypoxanthine by calf intestinal brush border membrane vesicles. J Comp Physiol B. 2003;173:165-70 pubmed
    ..These findings represent the first demonstration of active Na(+) gradient-dependent nucleobase transport in intestinal brush border membrane vesicles. ..
  14. Fotopoulos G, Harari A, Michetti P, Trono D, Pantaleo G, Kraehenbuhl J. Transepithelial transport of HIV-1 by M cells is receptor-mediated. Proc Natl Acad Sci U S A. 2002;99:9410-4 pubmed
    ..The follicle-associated epithelium covering human gut lymphoid follicles expresses CCR5, but not CXCR4, and lactosyl cerebroside, suggesting that HIV-1 infection may occur through M cells and enterocytes at these sites. ..
  15. Frischknecht R, Fejtova A, Viesti M, Stephan A, Sonderegger P. Activity-induced synaptic capture and exocytosis of the neuronal serine protease neurotrypsin. J Neurosci. 2008;28:1568-79 pubmed publisher
    ..Thereby, neurotrypsin may play a role in activity-dependent remodeling of the synaptic circuitry that is key to adaptive synaptic changes in the context of cognitive functions, such as learning and memory. ..
  16. Niederberger C, Gräub R, Schweingruber A, Fankhauser H, Rusu M, Poitelea M, et al. Exogenous inositol and genes responsible for inositol transport are required for mating and sporulation in Shizosaccharomyces pombe. Curr Genet. 1998;33:255-61 pubmed
    ..Mutant IM49 is also complemented by a multicopy suppressor gene (itr1) which codes for a putative hexose transporter with unknown substrate specifity. ..