Experts and Doctors on activating transcription factor 3 in United States


Locale: United States
Topic: activating transcription factor 3

Top Publications

  1. Brewer K, Lee J, Downs H, Oaklander A, Yezierski R. Dermatomal scratching after intramedullary quisqualate injection: correlation with cutaneous denervation. J Pain. 2008;9:999-1005 pubmed publisher
    ..Self-injurious dermatomal scratching that develops in spinal-injured rats may reflect neuropathic itch and loss of protective pain sensations. ..
  2. Cui H, Li X, Han C, Wang Q, Wang H, Ding H, et al. The Stress-responsive Gene ATF3 Mediates Dichotomous UV Responses by Regulating the Tip60 and p53 Proteins. J Biol Chem. 2016;291:10847-57 pubmed publisher
    ..As a result, ATF3 rather protected the p53 wild-type cells from UV-induced apoptosis. Our results thus indicate that ATF3 regulates cell fates upon UV irradiation in a p53-dependent manner. ..
  3. Zigmond R, Vaccariello S. Activating transcription factor 3 immunoreactivity identifies small populations of axotomized neurons in rat cervical sympathetic ganglia after transection of the preganglionic cervical sympathetic trunk. Brain Res. 2007;1159:119-23 pubmed
  4. Hai T, Jalgaonkar S, Wolford C, Yin X. Immunohistochemical detection of activating transcription factor 3, a hub of the cellular adaptive-response network. Methods Enzymol. 2011;490:175-94 pubmed publisher
  5. Xu M, Aita M, Chavkin C. Partial infraorbital nerve ligation as a model of trigeminal nerve injury in the mouse: behavioral, neural, and glial reactions. J Pain. 2008;9:1036-48 pubmed publisher
    ..Our goal is to devise better treatments of trigeminal pain, and this will be facilitated by characterization of the underlying cellular and molecular neuropathological mechanisms in genetically designed mice. ..
  6. Ueki Y, Karl M, Sudar S, Pollak J, Taylor R, Loeffler K, et al. P53 is required for the developmental restriction in Müller glial proliferation in mouse retina. Glia. 2012;60:1579-89 pubmed publisher
    ..These data show that p53 plays an essential role in limiting the potential of Müller glia to re-enter the mitotic cycle as the retina matures during postnatal development. ..
  7. Li D, Yin X, Zmuda E, Wolford C, Dong X, White M, et al. The repression of IRS2 gene by ATF3, a stress-inducible gene, contributes to pancreatic beta-cell apoptosis. Diabetes. 2008;57:635-44 pubmed
    ..Because ATF3 is a stress-inducible gene, our work provides a direct link to explain how environmental stress factors can modulate IRS2 gene transcription. ..
  8. Albershardt T, Salerni B, Soderquist R, Bates D, Pletnev A, Kisselev A, et al. Multiple BH3 mimetics antagonize antiapoptotic MCL1 protein by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA. J Biol Chem. 2011;286:24882-95 pubmed publisher
    ..Our findings highlight a novel signaling pathway through which many BH3 mimetics inhibit MCL1 and suggest the potential use of these agents as adjuvants in combination with various chemotherapy strategies. ..
  9. Pan Y, Chen H, Thiaville M, Kilberg M. Activation of the ATF3 gene through a co-ordinated amino acid-sensing response programme that controls transcriptional regulation of responsive genes following amino acid limitation. Biochem J. 2007;401:299-307 pubmed

More Information


  1. Pan Y, Chen H, Kilberg M. Interaction of RNA-binding proteins HuR and AUF1 with the human ATF3 mRNA 3'-untranslated region regulates its amino acid limitation-induced stabilization. J Biol Chem. 2005;280:34609-16 pubmed
    ..The results demonstrated that coordinated regulation of mRNA stability by HuR and AUF1 proteins contributes to the observed increase in ATF3 expression following amino acid limitation. ..
  2. Yin X, DeWille J, Hai T. A potential dichotomous role of ATF3, an adaptive-response gene, in cancer development. Oncogene. 2008;27:2118-27 pubmed
    ..These results provided a correlative argument that it is advantageous for the malignant cancer cells to express ATF3, consistent with its oncogenic roles suggested by the MCF10CA1a cell data. ..
  3. Pan Y, Chen H, Siu F, Kilberg M. Amino acid deprivation and endoplasmic reticulum stress induce expression of multiple activating transcription factor-3 mRNA species that, when overexpressed in HepG2 cells, modulate transcription by the human asparagine synthetase promoter. J Biol Chem. 2003;278:38402-12 pubmed
    ..Collectively, the results provide evidence for a potential role of multiple predicted ATF3 isoforms in the transcriptional regulation of the ASNS gene in response to nutrient deprivation. ..
  4. Yin X, Wolford C, Chang Y, McConoughey S, Ramsey S, Aderem A, et al. ATF3, an adaptive-response gene, enhances TGF{beta} signaling and cancer-initiating cell features in breast cancer cells. J Cell Sci. 2010;123:3558-65 pubmed publisher
    ..Because ATF3 is an adaptive-response gene and is induced by various stromal signals, these findings have significant implications for how the tumor microenvironment might affect cancer development. ..
  5. Habecker B, Sachs H, Rohrer H, Zigmond R. The dependence on gp130 cytokines of axotomy induced neuropeptide expression in adult sympathetic neurons. Dev Neurobiol. 2009;69:392-400 pubmed publisher
    ..The increase in cholecystokinin after axotomy, however, does not require the action of these cytokines. ..
  6. Liu W, Iiizumi Gairani M, Okuda H, Kobayashi A, Watabe M, Pai S, et al. KAI1 gene is engaged in NDRG1 gene-mediated metastasis suppression through the ATF3-NFkappaB complex in human prostate cancer. J Biol Chem. 2011;286:18949-59 pubmed publisher
    ..Taken together, our result revealed a novel regulatory network of two metastasis suppressor genes, NDRG1 and KAI1, which together concerted metastasis-suppressive activities through an intrinsic transcriptional cascade. ..
  7. Kiryu Seo S, Ohno N, Kidd G, Komuro H, Trapp B. Demyelination increases axonal stationary mitochondrial size and the speed of axonal mitochondrial transport. J Neurosci. 2010;30:6658-66 pubmed publisher
    ..In response to insufficient ATP production, demyelinated axons increase the size of stationary mitochondrial sites and thereby balance ATP production with the increased energy needs of nerve conduction. ..
  8. Saul K, Koke J, Garcia D. Activating transcription factor 3 (ATF3) expression in the neural retina and optic nerve of zebrafish during optic nerve regeneration. Comp Biochem Physiol A Mol Integr Physiol. 2010;155:172-82 pubmed publisher
    ..We conclude ATF3 may be an important mediator of optic nerve regeneration-promoting gene expression in fish, a role which merits further investigation. ..
  9. Lu D, Wolfgang C, Hai T. Activating transcription factor 3, a stress-inducible gene, suppresses Ras-stimulated tumorigenesis. J Biol Chem. 2006;281:10473-81 pubmed
    ..Potential explanations for the controversy about the roles of ATF3 in cell cycle and cell death are discussed. ..
  10. Bakin A, Stourman N, Sekhar K, Rinehart C, Yan X, Meredith M, et al. Smad3-ATF3 signaling mediates TGF-beta suppression of genes encoding Phase II detoxifying proteins. Free Radic Biol Med. 2005;38:375-87 pubmed
  11. Fu L, Kilberg M. Elevated cJUN expression and an ATF/CRE site within the ATF3 promoter contribute to activation of ATF3 transcription by the amino acid response. Physiol Genomics. 2013;45:127-37 pubmed publisher
    ..The results indicate that both increased cJUN and the cis-acting ATF/CRE sequence within the ATF3 promoter contribute to the transcriptional activation of the gene during the AAR...
  12. Hartman M, Lu D, Kim M, Kociba G, Shukri T, Buteau J, et al. Role for activating transcription factor 3 in stress-induced beta-cell apoptosis. Mol Cell Biol. 2004;24:5721-32 pubmed
    ..Taken together, our results suggest ATF3 to be a novel regulator of stress-induced beta-cell apoptosis. ..
  13. Fernández Verdejo R, Vanwynsberghe A, Hai T, Deldicque L, Francaux M. Activating transcription factor 3 regulates chemokine expression in contracting C2C12 myotubes and in mouse skeletal muscle after eccentric exercise. Biochem Biophys Res Commun. 2017;492:249-254 pubmed publisher
    ..Our results also indicate that ATF3-independent mechanisms would regulate macrophage infiltration upon muscle-damaging exercise. The implications of chemokine regulation in skeletal muscle remain to be determined. ..
  14. Allen Jennings A, Hartman M, Kociba G, Hai T. The roles of ATF3 in glucose homeostasis. A transgenic mouse model with liver dysfunction and defects in endocrine pancreas. J Biol Chem. 2001;276:29507-14 pubmed
    ..Because ATF3 is a stress-inducible gene, these mice may represent a model to investigate the molecular mechanisms for some stress-associated diseases. ..
  15. Hai T, Wolfgang C, Marsee D, Allen A, Sivaprasad U. ATF3 and stress responses. Gene Expr. 1999;7:321-35 pubmed
    ..Even less is understood about the physiological significance of inducing ATF3. We will discuss our preliminary results and some reports by other investigators in this regard. ..
  16. Chen B, Liang G, Whelan J, Hai T. ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms. J Biol Chem. 1994;269:15819-26 pubmed
    ..It is possible that ATF3 delta Zip is a physiologically important regulator and that it, together with ATF3, regulates the expression of specific target genes. ..
  17. Binder A, Grammer J, Herndon M, Stanton J, Nilson J. GnRH regulation of Jun and Atf3 requires calcium, calcineurin, and NFAT. Mol Endocrinol. 2012;26:873-86 pubmed publisher
    ..Together these data suggest that calcineurin and NFAT are new members of the gonadotrope transcriptional network that confer hormonal responsiveness to several key genes required for gonadotropin synthesis and secretion. ..
  18. Wang H, Jiang M, Cui H, Chen M, Buttyan R, Hayward S, et al. The stress response mediator ATF3 represses androgen signaling by binding the androgen receptor. Mol Cell Biol. 2012;32:3190-202 pubmed publisher
  19. Balasubramanian M, Shan J, Kilberg M. Dynamic changes in genomic histone association and modification during activation of the ASNS and ATF3 genes by amino acid limitation. Biochem J. 2013;449:219-29 pubmed publisher
    ..The results of the present study document changes in gene-associated nucleosome abundance and histone modifications in response to amino-acid-dependent transcription. ..
  20. Hai T, Wolford C, Chang Y. ATF3, a hub of the cellular adaptive-response network, in the pathogenesis of diseases: is modulation of inflammation a unifying component?. Gene Expr. 2010;15:1-11 pubmed
    ..Putting this in the context of the hub idea, we propose that modulation of inflammation by ATF3 is a unifying theme for the potential involvement of ATF3 in various diseases. ..
  21. Wolford C, McConoughey S, Jalgaonkar S, Leon M, Merchant A, Dominick J, et al. Transcription factor ATF3 links host adaptive response to breast cancer metastasis. J Clin Invest. 2013;123:2893-906 pubmed publisher
    ..In conclusion, we identified ATF3 as a regulator in myeloid cells that enhances breast cancer metastasis and has predictive value for clinical outcomes. ..
  22. Liang G, Wolfgang C, Chen B, Chen T, Hai T. ATF3 gene. Genomic organization, promoter, and regulation. J Biol Chem. 1996;271:1695-701 pubmed
    ..A possible mechanism implicating the C-Jun NH2-terminal kinase/stress-activated protein kinase (JNK/SAPK) stress-inducible signaling pathway in the induction of the ATF3 gene is discussed. ..
  23. Bandyopadhyay S, Wang Y, Zhan R, Pai S, Watabe M, Iiizumi M, et al. The tumor metastasis suppressor gene Drg-1 down-regulates the expression of activating transcription factor 3 in prostate cancer. Cancer Res. 2006;66:11983-90 pubmed
    ..Taken together, our results strongly suggest that Drg-1 suppresses metastasis of prostate tumor cells, at least in part, by inhibiting the invasive ability of the cells via down-regulation of the expression of the ATF3 gene. ..
  24. Hai T, Hartman M. The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis. Gene. 2001;273:1-11 pubmed
    ..Despite the diversity in the potential functions of these proteins, one common theme is their involvement in cellular responses to extracellular signals, indicating a role for these ATF proteins in homeostasis. ..
  25. Chen H, Pan Y, Dudenhausen E, Kilberg M. Amino acid deprivation induces the transcription rate of the human asparagine synthetase gene through a timed program of expression and promoter binding of nutrient-responsive basic region/leucine zipper transcription factors as well as localized his. J Biol Chem. 2004;279:50829-39 pubmed
    ..The data suggest that ATF3-FL and C/EBPbeta act as transcriptional suppressors for the ASNS gene to counterbalance the transcription rate activated by ATF4 following amino acid deprivation. ..
  26. Keeton A, Bortoff K, Franklin J, Messina J. Blockade of rapid versus prolonged extracellularly regulated kinase 1/2 activation has differential effects on insulin-induced gene expression. Endocrinology. 2005;146:2716-25 pubmed
  27. Gilchrist M, Thorsson V, Li B, Rust A, Korb M, Roach J, et al. Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4. Nature. 2006;441:173-8 pubmed
    ..Because ATF3 is itself induced by lipopolysaccharide, it seems to regulate TLR-stimulated inflammatory responses as part of a negative-feedback loop. ..
  28. Lu D, Chen J, Hai T. The regulation of ATF3 gene expression by mitogen-activated protein kinases. Biochem J. 2007;401:559-67 pubmed
  29. Lopez A, Wang C, Huang C, Yaman I, Li Y, Chakravarty K, et al. A feedback transcriptional mechanism controls the level of the arginine/lysine transporter cat-1 during amino acid starvation. Biochem J. 2007;402:163-73 pubmed
    ..These results suggest that the transient increase in cat-1 transcription is due to transcriptional activation caused by ATF4 followed by transcriptional repression by ATF3 via a feedback mechanism. ..
  30. Zmuda E, Viapiano M, Grey S, Hadley G, Garcia Ocana A, Hai T. Deficiency of Atf3, an adaptive-response gene, protects islets and ameliorates inflammation in a syngeneic mouse transplantation model. Diabetologia. 2010;53:1438-50 pubmed publisher
    ..ATF3 plays a role in islet graft rejection by contributing to islet cell death and inflammatory responses at the graft sites. Silencing the ATF3 gene may provide therapeutic benefits in islet transplantation. ..
  31. Whitmore M, Iparraguirre A, Kubelka L, Weninger W, Hai T, Williams B. Negative regulation of TLR-signaling pathways by activating transcription factor-3. J Immunol. 2007;179:3622-30 pubmed
    ..ATF3 dysregulation merits further exploration in diseases such as type I diabetes and cancer, where altered innate immunity has been implicated in their pathogenesis. ..
  32. Litvak V, Ramsey S, Rust A, Zak D, Kennedy K, Lampano A, et al. Function of C/EBPdelta in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals. Nat Immunol. 2009;10:437-43 pubmed publisher
    ..Our results suggest a mechanism that enables the innate immune system to detect the duration of infection and to respond appropriately. ..
  33. Hyatt Sachs H, Schreiber R, Shoemaker S, Sabe A, Reed E, Zigmond R. Activating transcription factor 3 induction in sympathetic neurons after axotomy: response to decreased neurotrophin availability. Neuroscience. 2007;150:887-97 pubmed
  34. Young B, Girard B, Parsons R. Neurturin suppresses injury-induced neuronal activating transcription factor 3 expression in cultured guinea pig cardiac ganglia. J Comp Neurol. 2008;508:795-805 pubmed publisher
    ..It is proposed that the loss of target-derived neurturin is a potential mechanism stimulating injury-induced expression of ATF-3 in cardiac neurons. ..
  35. Mo P, Wang H, Lu H, Boyd D, Yan C. MDM2 mediates ubiquitination and degradation of activating transcription factor 3. J Biol Chem. 2010;285:26908-15 pubmed publisher
    ..Therefore, we provide the first evidence demonstrating that ATF3 is regulated by a posttranslational mechanism. ..
  36. Zmuda E, Qi L, Zhu M, Mirmira R, Montminy M, Hai T. The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction. Mol Endocrinol. 2010;24:1423-33 pubmed publisher
    ..In conclusion, our results support a model in which, before apoptosis becomes obvious, expression of ATF3 can be beneficial by helping beta-cells to cope with higher metabolic demand. ..
  37. Allen Jennings A, Hartman M, Kociba G, Hai T. The roles of ATF3 in liver dysfunction and the regulation of phosphoenolpyruvate carboxykinase gene expression. J Biol Chem. 2002;277:20020-5 pubmed
    ..Because ATF3 is a stress-inducible gene, these mice may provide a model to investigate the molecular mechanisms of some stress-associated liver diseases. ..
  38. Okamoto Y, Chaves A, Chen J, Kelley R, Jones K, Weed H, et al. Transgenic mice with cardiac-specific expression of activating transcription factor 3, a stress-inducible gene, have conduction abnormalities and contractile dysfunction. Am J Pathol. 2001;159:639-50 pubmed
    ..Taken together, our results indicate that expression of ATF3, a stress-inducible gene, in the heart leads to altered gene expression and impaired cardiac function. ..
  39. Wang H, Mo P, Ren S, Yan C. Activating transcription factor 3 activates p53 by preventing E6-associated protein from binding to E6. J Biol Chem. 2010;285:13201-10 pubmed publisher
    ..These results indicate that ATF3 plays a key role in a mechanism defending against HPV-induced carcinogenesis, and could serve as a novel therapeutic target for HPV-positive cancers. ..