Genomes and Genes
Experts and Doctors on action potentials in United Kingdom
Locale: United Kingdom
Topic: action potentials
Publications105 found, 100 shown here
- Straub V, Staras K, Kemenes G, Benjamin P. Endogenous and network properties of Lymnaea feeding central pattern generator interneurons. J Neurophysiol. 2002;88:1569-83 pubmed..This is an example of a CPG system where the initiation of each cycle appears to be determined by the intrinsic properties of a key interneuron, N1M, but most other features of the rhythm are probably determined by network interactions...
- Gentle M. Cutaneous sensory afferents recorded from the nervus intramandibularis of Gallus gallus var domesticus. J Comp Physiol A. 1989;164:763-74 pubmed..Both units had fibres conducting in the 50 m/s range with thresholds in the 0.1 to 10 g range. The results are discussed in relation to the receptors found in other avian species and mammalian peripheral sensory afferents. ..
- Brette F, Orchard C. No apparent requirement for neuronal sodium channels in excitation-contraction coupling in rat ventricular myocytes. Circ Res. 2006;98:667-74 pubmed..We conclude that neuronal INa is concentrated at the t-tubules, but there is no evidence of a requirement for these channels in normal excitation-contraction coupling in ventricular myocytes. ..
- Djouhri L, Koutsikou S, Fang X, McMullan S, Lawson S. Spontaneous pain, both neuropathic and inflammatory, is related to frequency of spontaneous firing in intact C-fiber nociceptors. J Neurosci. 2006;26:1281-92 pubmed..Overall, SFL was related to SA rate in intact C-nociceptors. Both L5 degeneration and chromic gut cause inflammation. Therefore, both SA and SFL/spontaneous pain after nerve injury (mSNA) may result from cumulative neuroinflammation. ..
- Jeewajee A, Lever C, Burton S, O KEEFE J, Burgess N. Environmental novelty is signaled by reduction of the hippocampal theta frequency. Hippocampus. 2008;18:340-8 pubmed
- Zhao C, Dreosti E, Lagnado L. Homeostatic synaptic plasticity through changes in presynaptic calcium influx. J Neurosci. 2011;31:7492-6 pubmed publisher..These results indicate that changes in the number and/or function of presynaptic calcium channels are major determinants of homeostatic changes in synaptic strength. ..
- Clayton E, Anggono V, Smillie K, Chau N, Robinson P, Cousin M. The phospho-dependent dynamin-syndapin interaction triggers activity-dependent bulk endocytosis of synaptic vesicles. J Neurosci. 2009;29:7706-17 pubmed publisher..The results reveal that the phospho-dependent dynamin-syndapin interaction recruits ADBE to massively increase SV endocytosis under conditions of elevated neuronal activity. ..
- Hennig M, Grady J, van Coppenhagen J, Sernagor E. Age-dependent homeostatic plasticity of GABAergic signaling in developing retinal networks. J Neurosci. 2011;31:12159-64 pubmed publisher..This demonstrates that homeostatic control of spontaneous retinal activity maintains specific network dynamic properties in an age-dependent manner, and suggests that the underlying mechanism is linked to GABA(A) signaling. ..
- Komukai K, Brette F, Pascarel C, Orchard C. Electrophysiological response of rat ventricular myocytes to acidosis. Am J Physiol Heart Circ Physiol. 2002;283:H412-22 pubmed..Acidosis increased I(Cl,ir); it is suggested that the acidosis-induced increase in I(Cl,ir) underlies the depolarization of the resting membrane potential. ..
- Moult P, Gladding C, Sanderson T, Fitzjohn S, Bashir Z, Molnar E, et al. Tyrosine phosphatases regulate AMPA receptor trafficking during metabotropic glutamate receptor-mediated long-term depression. J Neurosci. 2006;26:2544-54 pubmed..Together, these data suggest that activation of postsynaptic PTP results in tyrosine dephosphorylation of AMPARs and their removal from the synapse...
- Price C, Scott R, Rusakov D, Capogna M. GABA(B) receptor modulation of feedforward inhibition through hippocampal neurogliaform cells. J Neurosci. 2008;28:6974-82 pubmed publisher..The NGFC-CA1 pyramidal cell connection therefore provides a unique and subtle mechanism to shape the integration time domain for signals arriving via a major excitatory input to CA1 pyramidal cells. ..
- Cheung G, Jupp O, Cousin M. Activity-dependent bulk endocytosis and clathrin-dependent endocytosis replenish specific synaptic vesicle pools in central nerve terminals. J Neurosci. 2010;30:8151-61 pubmed publisher..The differential replenishment of specific SV pools by independent SV retrieval modes illustrates how previously experienced neuronal activity impacts the capability of central nerve terminals to respond to future stimuli. ..
- Tatulian L, Delmas P, Abogadie F, Brown D. Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine. J Neurosci. 2001;21:5535-45 pubmed..In unclamped neurons, retigabine produced a hyperpolarization and reduced the number of action potentials produced by depolarizing current injections, without change in action potential configuration...
- Davies B, Kearns I, Ure J, Davies C, Lathe R. Loss of hippocampal serine protease BSP1/neuropsin predisposes to global seizure activity. J Neurosci. 2001;21:6993-7000 pubmed
- Cheung G, Cousin M. Adaptor protein complexes 1 and 3 are essential for generation of synaptic vesicles from activity-dependent bulk endosomes. J Neurosci. 2012;32:6014-23 pubmed publisher..Thus, adaptor protein complexes 1 and 3 play an essential dual role in generation of synaptic vesicles during activity-dependent bulk endocytosis. ..
- Deuchars S, Milligan C, Stornetta R, Deuchars J. GABAergic neurons in the central region of the spinal cord: a novel substrate for sympathetic inhibition. J Neurosci. 2005;25:1063-70 pubmed
- Burrows M. Neural control and coordination of jumping in froghopper insects. J Neurophysiol. 2007;97:320-30 pubmed..These features of the motor pattern and the coupling between motor neurons to the two hind legs ensure powerful movements to propel rapid jumping. ..
- Macgregor A, Yamasaki M, Rakovic S, Sanders L, Parkesh R, Churchill G, et al. NAADP controls cross-talk between distinct Ca2+ stores in the heart. J Biol Chem. 2007;282:15302-11 pubmed..The observations are consistent with a novel role for NAADP in cardiac muscle mediated by Ca(2+) release from bafilomycin-sensitive acidic stores, which in turn enhances SR Ca(2+) release by increasing SR Ca(2+) load. ..
- Shah M, Migliore M, Valencia I, Cooper E, Brown D. Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons. Proc Natl Acad Sci U S A. 2008;105:7869-74 pubmed publisher..These results indicate that axonal Kv7 channels, by controlling axonal RMP and action potential threshold, are fundamental for regulating the inherent firing properties of CA1 hippocampal neurons. ..
- Pavlov I, Savtchenko L, Song I, Koo J, Pimashkin A, Rusakov D, et al. Tonic GABAA conductance bidirectionally controls interneuron firing pattern and synchronization in the CA3 hippocampal network. Proc Natl Acad Sci U S A. 2014;111:504-9 pubmed publisher..Thus, our observations suggest that tonic GABAA conductance can bidirectionally control brain rhythms through changes in the excitability of interneurons and in the temporal structure of their firing patterns. ..
- Grieves R, Jenkins B, Harland B, Wood E, Dudchenko P. Place field repetition and spatial learning in a multicompartment environment. Hippocampus. 2016;26:118-34 pubmed publisher..Thus place field repetition, or lack thereof, in these compartments was not dependent on extra-maze cues. Together, these results imply that place field repetition constrains spatial learning. ..
- Tyrer N, Pozza M, Humbel U, Peters B, Bacon J. The tritocerebral commissure 'dwarf' (TCD): a major GABA-immunoreactive descending interneuron in the locust. J Comp Physiol A. 1988;164:141-50 pubmed..Since it is easily accessible for physiological recording, its roles in circuits for particular components of behaviour should be amenable to investigation. ..
- Brette F, Komukai K, Orchard C. Validation of formamide as a detubulation agent in isolated rat cardiac cells. Am J Physiol Heart Circ Physiol. 2002;283:H1720-8 pubmed..We conclude that formamide washout induces detubulation of single rat ventricular myocytes, leaving the t tubules within the cell, but without direct effects on cell proteins that might alter cell function. ..
- Widmer H, Ferrigan L, Davies C, Cobb S. Evoked slow muscarinic acetylcholinergic synaptic potentials in rat hippocampal interneurons. Hippocampus. 2006;16:617-28 pubmed..The current study suggests that synaptic release of ACh results in a complex and differential mAChR-mediated modulation of cellular excitability within the hippocampal interneuron population. ..
- Ainge J, Tamosiunaite M, Woergoetter F, Dudchenko P. Hippocampal CA1 place cells encode intended destination on a maze with multiple choice points. J Neurosci. 2007;27:9769-79 pubmed
- Harris J, Attwell D. The energetics of CNS white matter. J Neurosci. 2012;32:356-71 pubmed publisher..Finally, we show that mitochondria in optic nerve axons could sustain measured firing rates with a plausible density of glucose transporters in the nodal membrane, without the need for energy transfer from oligodendrocytes. ..
- Evans M, Sammons R, Lebron S, Dumitrescu A, Watkins T, Uebele V, et al. Calcineurin signaling mediates activity-dependent relocation of the axon initial segment. J Neurosci. 2013;33:6950-63 pubmed publisher..Together, these results emphasize calcineurin as a vital player in the regulation of intrinsic plasticity as governed by the AIS. ..
- Slaght S, Leresche N, Deniau J, Crunelli V, Charpier S. Activity of thalamic reticular neurons during spontaneous genetically determined spike and wave discharges. J Neurosci. 2002;22:2323-34 pubmed..The unmasking of these properties in the GAERS NRT confirms their unique association with spontaneous genetically determined SWDs and thus their likely involvement in the pathophysiological processes of the human condition. ..
- Liu S, Cull Candy S. Activity-dependent change in AMPA receptor properties in cerebellar stellate cells. J Neurosci. 2002;22:3881-9 pubmed..The activity-induced expression of GluR2-containing receptors significantly reduced the Ca(2+) permeability of AMPARs in stellate cells but did not slow the decay time course of synaptic currents. ..
- Moss A, Blackburn Munro G, Garry E, Blakemore J, Dickinson T, Rosie R, et al. A role of the ubiquitin-proteasome system in neuropathic pain. J Neurosci. 2002;22:1363-72 pubmed
- Nabatiyan A, Poulet J, de Polavieja G, Hedwig B. Temporal pattern recognition based on instantaneous spike rate coding in a simple auditory system. J Neurophysiol. 2003;90:2484-93 pubmed..Thus temporal filtering or "pattern recognition" occurs at an early stage in the auditory pathway. ..
- Threlfell S, Cragg S, Kallo I, Turi G, Coen C, Greenfield S. Histamine H3 receptors inhibit serotonin release in substantia nigra pars reticulata. J Neurosci. 2004;24:8704-10 pubmed..The potent regulation of 5-HT by H3Rs reported here not only elucidates HA function in the SNr but also raises the possibility of novel targets for basal ganglia therapies. ..
- Cuthbert P, Stanford L, Coba M, Ainge J, Fink A, Opazo P, et al. Synapse-associated protein 102/dlgh3 couples the NMDA receptor to specific plasticity pathways and learning strategies. J Neurosci. 2007;27:2673-82 pubmed..This provides a mechanism for discriminating patterns of synaptic activity that lead to long-lasting changes in synaptic strength as well as distinct aspects of cognition in the mammalian nervous system. ..
- Trevelyan A. The direct relationship between inhibitory currents and local field potentials. J Neurosci. 2009;29:15299-307 pubmed publisher..This association suggests that a significant component of HFOs reflects the last act of defiance in the face of an advancing ictal event. ..
- O Neill M, Schultz W. Risk prediction error coding in orbitofrontal neurons. J Neurosci. 2013;33:15810-4 pubmed publisher..A group of orbitofrontal neurons displayed a risk signal that tracked the discrepancy between current and predicted risk. Such neuronal signals may be involved in the updating of risk information. ..
- de Blaquière G, Williams F, Blain P, Kelly S. A comparison of the electrophysiological effects of two organophosphates, mipafox and ecothiopate, on mouse limb muscles. Toxicol Appl Pharmacol. 1998;150:350-60 pubmed..The slow-twitch soleus appears more sensitive to prejunctional changes caused by OPs than the fast-twitch EDL. ..
- Cui Y, Giblin J, Clapp L, Tinker A. A mechanism for ATP-sensitive potassium channel diversity: Functional coassembly of two pore-forming subunits. Proc Natl Acad Sci U S A. 2001;98:729-34 pubmed..2 or Kir 6.1 expressed with SUR2B. In conclusion, Kir 6.1 and Kir 6.2 readily coassemble to produce functional channels, and such phenomena may contribute to the diversity of nucleotide-regulated potassium currents seen in native tissues...
- Wiegrebe L, Winter I. Temporal representation of iterated rippled noise as a function of delay and sound level in the ventral cochlear nucleus. J Neurophysiol. 2001;85:1206-19 pubmed..Their limited dynamic range together with the preservation of the temporal stimulus features in saturation may serve as a physiological basis for the perceived level independence of pitch...
- Crabtree J, Isaac J. New intrathalamic pathways allowing modality-related and cross-modality switching in the dorsal thalamus. J Neurosci. 2002;22:8754-61 pubmed..Moreover, TRN-mediated switching between dorsal thalamic nuclei could provide a mechanism for the selection of competing transmissions of sensory and/or motor information through the dorsal thalamus. ..
- Poulet J, Hedwig B. Corollary discharge inhibition of ascending auditory neurons in the stridulating cricket. J Neurosci. 2003;23:4717-25 pubmed..5 kHz stimuli. The hyperpolarization desensitized the response of AN1 to subsequent quieter stimuli. Therefore, the corollary discharge will reduce desensitization by suppressing the response of AN1 to self-generated sounds. ..
- Rong W, Gourine A, Cockayne D, Xiang Z, Ford A, Spyer K, et al. Pivotal role of nucleotide P2X2 receptor subunit of the ATP-gated ion channel mediating ventilatory responses to hypoxia. J Neurosci. 2003;23:11315-21 pubmed..We conclude that P2X receptors containing the P2X2 subunit play a pivotal role in carotid body function and in mediating ventilatory responses to hypoxia. ..
- Krug K, Cumming B, Parker A. Comparing perceptual signals of single V5/MT neurons in two binocular depth tasks. J Neurophysiol. 2004;92:1586-96 pubmed..The cortical circuitry must be able to make dynamic changes in the pools of neurons that underlie perceptual judgments according to the demands of the task. ..
- Burzomato V, Beato M, Groot Kormelink P, Colquhoun D, Sivilotti L. Single-channel behavior of heteromeric alpha1beta glycine receptors: an attempt to detect a conformational change before the channel opens. J Neurosci. 2004;24:10924-40 pubmed..Distinguishing between the two mechanisms will be important for our understanding of the structural dynamics of activation in the nicotinic superfamily and is important for our understanding of mutations in these receptors. ..
- Waller B, Vick S, Parr L, Bard K, Pasqualini M, Gothard K, et al. Intramuscular electrical stimulation of facial muscles in humans and chimpanzees: Duchenne revisited and extended. Emotion. 2006;6:367-82 pubmed
- Nolan M, Dudman J, Dodson P, Santoro B. HCN1 channels control resting and active integrative properties of stellate cells from layer II of the entorhinal cortex. J Neurosci. 2007;27:12440-51 pubmed
- Stagg M, Carter E, Sohrabi N, Siedlecka U, Soppa G, Mead F, et al. Cytoskeletal protein 4.1R affects repolarization and regulates calcium handling in the heart. Circ Res. 2008;103:855-63 pubmed publisher..1R in modulating the functional properties of several cardiac ion transporters with consequences on cardiac electrophysiology and with possible significant roles during normal cardiac function and disease. ..
- Hakim P, Gurung I, Pedersen T, Thresher R, Brice N, Lawrence J, et al. Scn3b knockout mice exhibit abnormal ventricular electrophysiological properties. Prog Biophys Mol Biol. 2008;98:251-66 pubmed publisher..Together, these findings associate the lack of the Scn3b gene with arrhythmic tendencies in intact perfused hearts and electrophysiological features similar to those in Scn5a(+/-) hearts. ..
- Atkinson S, Williams S. Postnatal development of dendritic synaptic integration in rat neocortical pyramidal neurons. J Neurophysiol. 2009;102:735-51 pubmed publisher..Thus an age-dependent increase in apical dendritic HCN channel density ensures that L5 pyramidal neurons develop from compact temporal integrators to compartmentalized integrators of basal and apical dendritic synaptic input. ..
- Kostarakos K, Hedwig B. Calling song recognition in female crickets: temporal tuning of identified brain neurons matches behavior. J Neurosci. 2012;32:9601-12 pubmed publisher..It is crucially linked to a change in auditory responsiveness during pulse intervals and based on fast interactions of inhibition and excitation...
- Bale M, Davies K, Freeman O, Ince R, Petersen R. Low-dimensional sensory feature representation by trigeminal primary afferents. J Neurosci. 2013;33:12003-12 pubmed publisher..Our results suggest that the first stage of the whisker system can be well approximated as a bank of linear filters, forming an overcomplete representation of a low-dimensional feature space. ..
- Lundgaard I, Luzhynskaya A, Stockley J, Wang Z, Evans K, Swire M, et al. Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes. PLoS Biol. 2013;11:e1001743 pubmed publisher..These data resolve controversies over the signalling regulating myelination and suggest novel roles for neuregulin in schizophrenia and in remyelination after white matter damage. ..
- Chimerel C, Riccio C, Murison K, Gribble F, Reimann F. Optogenetic Analysis of Depolarization-Dependent Glucagonlike Peptide-1 Release. Endocrinology. 2017;158:3426-3434 pubmed publisher..We conclude that cAMP elevation or cumulative membrane depolarization triggered by SSFO enhances the efficiency of light-triggered action potential firing, voltage-gated calcium entry, and GLP-1 secretion. ..
- Blethyn K, Hughes S, Toth T, Cope D, Crunelli V. Neuronal basis of the slow (<1 Hz) oscillation in neurons of the nucleus reticularis thalami in vitro. J Neurosci. 2006;26:2474-86 pubmed..In combination with previous work in thalamocortical neurons, this study suggests that the thalamus plays an important and active role in shaping the slow (<1 Hz) rhythm during deep sleep. ..
- Schuppe H, Cuttle M, Newland P. Nitric oxide modulates sodium taste via a cGMP-independent pathway. Dev Neurobiol. 2007;67:219-32 pubmed..The authors suggest that NO released from glandular cells modulates the responsiveness of chemosensory neurons to regulate NaCl intake, and hypothesize that NO may play a key role in the signaling of salt and sugars. ..
- Cruz A, Mallet N, Magill P, Brown P, Averbeck B. Effects of dopamine depletion on network entropy in the external globus pallidus. J Neurophysiol. 2009;102:1092-102 pubmed publisher..Thus it is possible that reduced information coding capacity within basal ganglia networks may contribute to the behavioral deficits accompanying PD. ..
- Holgado A, Terry J, Bogacz R. Conditions for the generation of beta oscillations in the subthalamic nucleus-globus pallidus network. J Neurosci. 2010;30:12340-52 pubmed publisher..These conditions describe changes in parameters that are consistent with those expected as a result of the development of Parkinson's disease, and predict manipulations that could inhibit the pathological oscillations. ..
- Krug K, Parker A. Neurons in dorsal visual area V5/MT signal relative disparity. J Neurosci. 2011;31:17892-904 pubmed publisher..This selectivity may be important for segmentation and depth order of moving visual features, particularly the processing of three-dimensional information in scenes viewed by an actively moving observer. ..
- Rorsman P, Braun M. Regulation of insulin secretion in human pancreatic islets. Annu Rev Physiol. 2013;75:155-79 pubmed publisher..Finally, we consider the pathophysiology of insulin secretion and the interactions between genetics and environmental factors that may explain the current diabetes epidemic. ..
- Dangerfield C, Kay D, Burrage K. Modeling ion channel dynamics through reflected stochastic differential equations. Phys Rev E Stat Nonlin Soft Matter Phys. 2012;85:051907 pubmed..This framework could easily be extended to other biochemical reaction networks. ..
- Skrzypiec A, Shah R, Schiavon E, Baker E, Skene N, Pawlak R, et al. Stress-induced lipocalin-2 controls dendritic spine formation and neuronal activity in the amygdala. PLoS ONE. 2013;8:e61046 pubmed publisher..Thus, amygdala-specific neuronal responses to Lcn-2 may represent a mechanism for behavioural adaptation to psychological stress. ..
- Tong H, Kopp Scheinpflug C, Pilati N, Robinson S, Sinclair J, Steinert J, et al. Protection from noise-induced hearing loss by Kv2.2 potassium currents in the central medial olivocochlear system. J Neurosci. 2013;33:9113-21 pubmed publisher..This safeguards efferent MOC firing during high-intensity sounds and is crucial in the mediation of protection after auditory overexposure. ..
- Li M, Hothi S, Salvage S, Jeevaratnam K, Grace A, Huang C. Arrhythmic effects of Epac-mediated ryanodine receptor activation in Langendorff-perfused murine hearts are associated with reduced conduction velocity. Clin Exp Pharmacol Physiol. 2017;44:686-692 pubmed publisher..We thus demonstrate for the first time that acute RyR2 activation reversibly induces VT in specific association with reduced CV. ..
- SHEETS L, He X, Olt J, Schreck M, Petralia R, Wang Y, et al. Enlargement of Ribbons in Zebrafish Hair Cells Increases Calcium Currents But Disrupts Afferent Spontaneous Activity and Timing of Stimulus Onset. J Neurosci. 2017;37:6299-6313 pubmed publisher..These observations suggest that varying ribbon size alone can influence sensory encoding, and give further insight into how hair cells transduce signals that cover a wide dynamic range of stimuli. ..
- Witchel H, Hancox J. Familial and acquired long qt syndrome and the cardiac rapid delayed rectifier potassium current. Clin Exp Pharmacol Physiol. 2000;27:753-66 pubmed..Until such time, awareness of the QT-prolongation risk of particular agents is important for the clinician. ..
- Ingham N, Hart H, McAlpine D. Spatial receptive fields of inferior colliculus neurons to auditory apparent motion in free field. J Neurophysiol. 2001;85:23-33 pubmed..In addition, the data indicate that the sequential activation of an array of speakers to produce apparent auditory motion may not be an optimal stimulus paradigm to separate the temporal and spatial aspects of auditory motion processing...
- Baker S, Spinks R, Jackson A, Lemon R. Synchronization in monkey motor cortex during a precision grip task. I. Task-dependent modulation in single-unit synchrony. J Neurophysiol. 2001;85:869-85 pubmed
- Traub R, Bibbig R, Piechotta A, Draguhn R, Schmitz D. Synaptic and nonsynaptic contributions to giant ipsps and ectopic spikes induced by 4-aminopyridine in the hippocampus in vitro. J Neurophysiol. 2001;85:1246-56 pubmed..We conclude that in 4-AP, axonal gap junctions could, at least in principle, account in part for both the large IPSPs, and for the antidromic activity in pyramidal neurons...
- Krug K, Akerman C, Thompson I. Responses of neurons in neonatal cortex and thalamus to patterned visual stimulation through the naturally closed lids. J Neurophysiol. 2001;85:1436-43 pubmed..This could have important implications for the self-organization of visual cortex...
- Allen N, Rossi D, Attwell D. Sequential release of GABA by exocytosis and reversed uptake leads to neuronal swelling in simulated ischemia of hippocampal slices. J Neurosci. 2004;24:3837-49 pubmed..These data show that ischemia releases GABA initially by exocytosis and then by reversal of GAT-1 transporters and that the resulting Cl- influx through GABA(A) receptor channels causes potentially neurotoxic cell swelling. ..
- Papaioannou S, Marsden D, Franks C, Walker R, Holden Dye L. Role of a FMRFamide-like family of neuropeptides in the pharyngeal nervous system of Caenorhabditis elegans. J Neurobiol. 2005;65:304-19 pubmed..Overall, this study demonstrates the impressive neurochemical complexity of the simple circuit that regulates feeding in the nematode, C. elegans. ..
- Fang X, Djouhri L, McMullan S, Berry C, Waxman S, Okuse K, et al. Intense isolectin-B4 binding in rat dorsal root ganglion neurons distinguishes C-fiber nociceptors with broad action potentials and high Nav1.9 expression. J Neurosci. 2006;26:7281-92 pubmed..We conclude that strongly IB4+ DRG neurons are exclusively C-nociceptor type and that high Nav1.9 expression may contribute to their distinct membrane properties. ..
- Katzner S, Busse L, Carandini M. GABAA inhibition controls response gain in visual cortex. J Neurosci. 2011;31:5931-41 pubmed publisher..It controls the sensitivity of V1 neurons by adjusting their response gain, without affecting their input gain. ..
- Wijekoon J, Dudek P. VLSI circuits implementing computational models of neocortical circuits. J Neurosci Methods. 2012;210:93-109 pubmed publisher..The paper presents experimental results obtained from the fabricated devices, and discusses the advantages and disadvantages of the analogue circuit approach to computational neural modelling. ..
- Klyuch B, Dale N, Wall M. Deletion of ecto-5'-nucleotidase (CD73) reveals direct action potential-dependent adenosine release. J Neurosci. 2012;32:3842-7 pubmed publisher..Our findings are a major step in understanding the mechanisms of adenosine release and are likely to have implications for all aspects of physiology where adenosine plays a key modulatory role. ..
- Zecharia A, Yu X, GÃ¶tz T, Ye Z, Carr D, Wulff P, et al. GABAergic inhibition of histaminergic neurons regulates active waking but not the sleep-wake switch or propofol-induced loss of consciousness. J Neurosci. 2012;32:13062-75 pubmed..GABA(B) receptors on histaminergic neurons were dispensable for all behaviors examined. Synaptic inhibition of histaminergic cells by GABA(A) receptors, however, was essential for habituation to a novel environment. ..
- Douchamps V, Jeewajee A, Blundell P, Burgess N, Lever C. Evidence for encoding versus retrieval scheduling in the hippocampus by theta phase and acetylcholine. J Neurosci. 2013;33:8689-704 pubmed publisher..Also consistent with cholinergic enhancement of encoding, scopolamine attenuated the formation of distinct spatial representations in a new environment, reducing the extent of place cell "remapping." ..
- Edwards I, Bruce G, Lawrenson C, Howe L, Clapcote S, Deuchars S, et al. Na+/K+ ATPase ?1 and ?3 isoforms are differentially expressed in ?- and ?-motoneurons. J Neurosci. 2013;33:9913-9 pubmed publisher..The selective expression of NKA?3 in ?-motoneurons and muscle spindle afferents, which may affect excitability of these neurons, has implications in motor control and disease states associated with NKA?3 dysfunction. ..
- Connelly W, Crunelli V, Errington A. Variable Action Potential Backpropagation during Tonic Firing and Low-Threshold Spike Bursts in Thalamocortical But Not Thalamic Reticular Nucleus Neurons. J Neurosci. 2017;37:5319-5333 pubmed publisher..Therefore, backpropagating spikes in these cells can only influence signaling in the proximal part of the dendritic tree. ..
- Grubb M, Thompson I. Visual response properties in the dorsal lateral geniculate nucleus of mice lacking the beta2 subunit of the nicotinic acetylcholine receptor. J Neurosci. 2004;24:8459-69 pubmed
- Mee C, Pym E, Moffat K, Baines R. Regulation of neuronal excitability through pumilio-dependent control of a sodium channel gene. J Neurosci. 2004;24:8695-703 pubmed..We show, through use of anemone toxin (ATX II), that alteration in persistent I(Na) is sufficient to regulate membrane excitability in these two motoneurons. ..