Experts and Doctors on actins in Japan


Locale: Japan
Topic: actins

Top Publications

  1. Abe H, Nagaoka R, Obinata T. Cytoplasmic localization and nuclear transport of cofilin in cultured myotubes. Exp Cell Res. 1993;206:1-10 pubmed
    ..Thus, we suggest that the phosphorylation of cofilin itself is not directly involved in its nuclear transport at least in myotubes. ..
  2. Asano K, Taniguchi S, Nakao A, Maruyama T, Watanabe T, Kurokawa K. Distribution of thromboxane A2 receptor mRNA along the mouse nephron segments. Biochem Biophys Res Commun. 1996;226:613-7 pubmed
    ..These results suggest the potential physiological roles of TXA2 in the entire renal tubule as well as in the glomerulus. ..
  3. Moriyama T, Kawada N, Ando A, Yamauchi A, Horio M, Nagata K, et al. Up-regulation of HSP47 in the mouse kidneys with unilateral ureteral obstruction. Kidney Int. 1998;54:110-9 pubmed
    ..Identification of the molecular mechanism of HSP47 induction during UUO may give an insight into the novel aspects of the molecular pathophysiology of interstitial fibrosis in obstructive nephropathy. ..
  4. Arai R, Nakano K, Mabuchi I. Subcellular localization and possible function of actin, tropomyosin and actin-related protein 3 (Arp3) in the fission yeast Schizosaccharomyces pombe. Eur J Cell Biol. 1998;76:288-95 pubmed
  5. Nwe T, Maruyama K, Shimada Y. Relation of nebulin and connectin (titin) to dynamics of actin in nascent myofibrils of cultured skeletal muscle cells. Exp Cell Res. 1999;252:33-40 pubmed
    ..Connectin formed a striated pattern before the formation of rh-actin/nebulin striations. It appears that connectin does not have any significant role in the accessibility of actin into nascent myofibrils. ..
  6. Numata O, Gonda K, Watanabe A, Kurasawa Y. Cytokinesis in Tetrahymena: determination of division plane and organization of contractile ring. Microsc Res Tech. 2000;49:127-35 pubmed
  7. Sameshima M, Kishi Y, Osumi M, Mahadeo D, Cotter D. Novel actin cytoskeleton: actin tubules. Cell Struct Funct. 2000;25:291-5 pubmed
    ..The complex organization of actin filaments, actin tubules and rods may be required for spores to achieve complete dormancy and maintain viability. ..
  8. Kishi Y, Sugo T, Mahadeo D, Cotter D, Sameshima M. S-Adenosyl-L-homocysteine hydrolase is sequestered into actin rods in Dictyostelium discoideum spores. FEBS Lett. 2001;508:433-7 pubmed
    ..discoideum. Recently SAHH is believed to be a target for antiviral chemotherapy and the suppression of T cells. Our finding may contribute to designing novel antiviral and immunosuppressive drugs. ..
  9. Fujita J, Ohtsuki Y, Suemitsu I, Yamadori I, Shigeto E, Shiode M, et al. Immunohistochemical distribution of epithelioid cell, myofibroblast, and transforming growth factor-beta1 in the granuloma caused by Mycobacterium avium intracellulare complex pulmonary infection. Microbiol Immunol. 2002;46:67-74 pubmed

More Information

Publications135 found, 100 shown here

  1. Zhao Q, Murakami Y, Tohda M, Obi R, Shimada Y, Matsumoto K. Chotosan, a kampo formula, ameliorates chronic cerebral hypoperfusion-induced deficits in object recognition behaviors and central cholinergic systems in mice. J Pharmacol Sci. 2007;103:360-73 pubmed
  2. Asano S, Hamao K, Hosoya H. Direct evidence for roles of phosphorylated regulatory light chain of myosin II in furrow ingression during cytokinesis in HeLa cells. Genes Cells. 2009;14:555-68 pubmed publisher
    ..These results suggest that the P-MRLC is essential for the progress of furrow ingression but not the retainment of F-actin and myosin II in the contractile ring of dividing HeLa cells. ..
  3. Sugita M, Nakano K, Sato M, Toyooka K, Numata O. The roles of actin cytoskeleton and microtubules for membrane recycling of a food vacuole in Tetrahymena thermophila. Cell Motil Cytoskeleton. 2009;66:371-7 pubmed publisher
    ..In addition, it was possible that microtubules might be involved in transportation of recycling vesicles of FV coated with F-actin. ..
  4. Tochio T, Tanaka H, Nakata S, Hosoya H. Fructose-1,6-bisphosphate aldolase A is involved in HaCaT cell migration by inducing lamellipodia formation. J Dermatol Sci. 2010;58:123-9 pubmed publisher
    ..We concluded that ALDOA is involved in keratinocyte migration following the induction of lamellipodia formation, and ALDOA-related migration is enhanced by EGF. ..
  5. Nakano K, Kuwayama H, Kawasaki M, Numata O, Takaine M. GMF is an evolutionarily developed Adf/cofilin-super family protein involved in the Arp2/3 complex-mediated organization of the actin cytoskeleton. Cytoskeleton (Hoboken). 2010;67:373-82 pubmed publisher
    ..Given the functional plasticity of ADF-H, GMF-family proteins possibly have changed their target from conventional actin to Arps through molecular evolution. ..
  6. Henmi Y, Tanabe K, Takei K. Disruption of microtubule network rescues aberrant actin comets in dynamin2-depleted cells. PLoS ONE. 2011;6:e28603 pubmed publisher
    ..This suggests that the alteration of microtubules by dynamin2 depletion reduced the length and the speed of the actin comet. ..
  7. Shiba Y, Sasaki Y, Kanno Y. 12-O-tetradecanoylphorbol-13-acetate disrupts actin filaments and focal contacts and enhances binding of fibronectin-coated latex beads to 3T3-L1 cells. Exp Cell Res. 1988;178:233-41 pubmed
  8. Hamaguchi A, Kim S, Ohta K, Yagi K, Yukimura T, Miura K, et al. Transforming growth factor-beta 1 expression and phenotypic modulation in the kidney of hypertensive rats. Hypertension. 1995;26:199-207 pubmed
    ..abstract truncated at 250 words) ..
  9. An H, Mogami K. Isolation of 88F actin mutants of Drosophila melanogaster and possible alterations in the mutant actin structures. J Mol Biol. 1996;260:492-505 pubmed
    ..On the basis of these phenotypes and the known atomic structure of actin, possible alterations in the structure of actin brought about by these mutations are discussed. ..
  10. Watabe S, Wada S, Saito S, Matsunaga S, Fusetani N, Ozaki H, et al. Cellular changes of rat embryonic fibroblasts by an actin-polymerization inhibitor, bistheonellide A, from a marine sponge. Cell Struct Funct. 1996;21:199-212 pubmed
    ..These results reveal that actin filaments are not only essential to cytokinesis but also for promoting the progression of cell cycle G1 to S phase. ..
  11. Soeno Y, Abe H, Kimura S, Maruyama K, Obinata T. Generation of functional beta-actinin (CapZ) in an E. coli expression system. J Muscle Res Cell Motil. 1998;19:639-46 pubmed
  12. Suzuki T, Mimuro H, Miki H, Takenawa T, Sasaki T, Nakanishi H, et al. Rho family GTPase Cdc42 is essential for the actin-based motility of Shigella in mammalian cells. J Exp Med. 2000;191:1905-20 pubmed
    ..These results suggest that Cdc42 activity is involved in initiating actin nucleation mediated by VirG-N-WASP-Arp2/3 complex formed on intracellular Shigella. ..
  13. Nagumo Y, Han J, Bellila A, Isoda H, Tanaka T. Cofilin mediates tight-junction opening by redistributing actin and tight-junction proteins. Biochem Biophys Res Commun. 2008;377:921-5 pubmed publisher
    ..These results strongly support the importance of cofilin in TJ opening, suggesting cofilin as a target for TJ permeability regulation in epithelial cells. ..
  14. Sakurai T, Kurokawa H, Nonomura Y. The Ca2(+)-dependent actin filament-severing activity of 74-kDa protein (adseverin) resides in its NH2-terminal half. J Biol Chem. 1991;266:4581-5 pubmed
    ..The sequence homology and similar functional domain structure suggest a common structural basis for the calcium- and phospholipid-regulated actin-severing properties shared by adseverin, gelsolin, and villin. ..
  15. Iino S. Muscular innervation of the proximal duodenum of the guinea pig. Arch Histol Cytol. 2000;63:327-43 pubmed
    ..The functional significance of the proximal duodenum in relation to the electrical connection and neural cooperation of the musculature between the antrum and the duodenum is also discussed. ..
  16. Kinebuchi Y, Johkura K, Sasaki K, Imamura T, Mimura Y, Nishizawa O. Direct induction of layered tissues from mouse embryonic stem cells: potential for differentiation into urinary tract tissue. Cell Tissue Res. 2008;331:605-15 pubmed
    ..These findings suggest a new approach to urinary tract regeneration...
  17. Onozuka I, Kakinuma S, Kamiya A, Miyoshi M, Sakamoto N, Kiyohashi K, et al. Cholestatic liver fibrosis and toxin-induced fibrosis are exacerbated in matrix metalloproteinase-2 deficient mice. Biochem Biophys Res Commun. 2011;406:134-40 pubmed publisher
    ..Our study demonstrated, using 2 experimental murine models, that loss of MMP-2 exacerbates liver fibrosis, and suggested that MMP-2 suppresses tissue inhibitor of metalloproteinase 1 up-regulation during liver fibrosis. ..
  18. Yamochi W, Tanaka K, Nonaka H, Maeda A, Musha T, Takai Y. Growth site localization of Rho1 small GTP-binding protein and its involvement in bud formation in Saccharomyces cerevisiae. J Cell Biol. 1994;125:1077-93 pubmed
    ..These results suggest that Rho1 small GTP-binding protein binds to a specific site at the growth region of cells, where Rho1p exerts its function in controlling cell growth. ..
  19. Mashima T, Naito M, Noguchi K, Miller D, Nicholson D, Tsuruo T. Actin cleavage by CPP-32/apopain during the development of apoptosis. Oncogene. 1997;14:1007-12 pubmed
    ..Our present results indicate that actin is the substrate of CPP-32/apopain(-like) protease both in vitro and in vivo and suggest the role of actin in the control of cell growth and apoptosis. ..
  20. Honda H, Oda H, Nakamoto T, Honda Z, Sakai R, Suzuki T, et al. Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas. Nat Genet. 1998;19:361-5 pubmed
    ..These findings have defined Cas function in cardiovascular development, actin filament assembly and Src-induced transformation. ..
  21. Horigane M, Ogihara K, Nakajima Y, Honda H, Taylor D. Identification and expression analysis of an actin gene from the soft tick, Ornithodoros moubata (Acari: Argasidae). Arch Insect Biochem Physiol. 2007;64:186-99 pubmed
    ..In addition, actin expression analyzed by real-time PCR before and after blood feeding was not significantly different indicating OmAct2 is an appropriate internal control for the analysis of gene expression in these ticks...
  22. Kakinuma N, Zhu Y, Wang Y, Roy B, Kiyama R. Kank proteins: structure, functions and diseases. Cell Mol Life Sci. 2009;66:2651-9 pubmed publisher
    ..Their relationship to diseases such as cancer, and to neuronal and developmental disorders, will be an important subject of future study. ..
  23. Ishiwata A, Mimuro J, Mizukami H, Kashiwakura Y, Takano K, Ohmori T, et al. Liver-restricted expression of the canine factor VIII gene facilitates prevention of inhibitor formation in factor VIII-deficient mice. J Gene Med. 2009;11:1020-9 pubmed publisher
    ..These data suggest that AAV8 vector-mediated liver-restricted cFVIII gene expression is sufficient for immune hypo-responsiveness to transgene-derived cFVIII in fviii(-/-) mice. ..
  24. Torashima Y, Uezono Y, Kanaide M, Ando Y, Enjoji A, Kanematsu T, et al. Presence of GABA(B) receptors forming heterodimers with GABA(B1) and GABA(B2) subunits in human lower esophageal sphincter. J Pharmacol Sci. 2009;111:253-9 pubmed
  25. Piyaviriyakul S, Shimizu K, Asakawa T, Kan T, Siripong P, Oku N. Anti-angiogenic activity and intracellular distribution of epigallocatechin-3-gallate analogs. Biol Pharm Bull. 2011;34:396-400 pubmed
    ..These results suggest that EGCG was incorporated into the HUVECs, that a portion of it entered into their mitochondria. ..
  26. Muramatsu T, Mizutani Y, Ohmori Y, Okumura J. Comparison of three nonviral transfection methods for foreign gene expression in early chicken embryos in ovo. Biochem Biophys Res Commun. 1997;230:376-80 pubmed
    ..The results suggest that as far as transient gene expression is concerned, electroporation would provide a useful and efficient nonviral means of foreign gene transfection to somatic cells of living chicken embryos in ovo. ..
  27. Higashi Fujime S, Hozumi T. Restoration of defective mechanochemical properties of cleaved actins by native tropomyosin: involvement of the 40-50 loop in subdomain 2 of actin in interaction with myosin and tropomyosin. Biochem Biophys Res Commun. 1997;237:121-5 pubmed
    ..These results suggested that the 40-50 loop in the small domain 2 of actin interacted directly or indirectly with tropomyosin and play a significant role in cross talk between myosin and native tropomyosin. ..
  28. Miki H, Sasaki T, Takai Y, Takenawa T. Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP. Nature. 1998;391:93-6 pubmed
    ..This activation seems to be caused by exposure of N-WASP's actin-depolymerizing region induced by Cdc42 binding. ..
  29. Mohri K, Takano Ohmuro H, Nakashima H, Hayakawa K, Endo T, Hanaoka K, et al. Expression of cofilin isoforms during development of mouse striated muscles. J Muscle Res Cell Motil. 2000;21:49-57 pubmed
    ..Only M-CF could be involved in actin dynamics in mature skeletal muscle, while both isoforms could be in the mature heart. ..
  30. Watanabe K, Baba K, Saito A, Hoshi N, Suzuki T. Pseudosarcomatous myofibroblastic tumor and myosarcoma of the urogenital tract. Arch Pathol Lab Med. 2001;125:1070-3 pubmed
    ..High-molecular-weight caldesmon and myogenin are useful for differentiating urogenital PMTs from myosarcomas. ..
  31. Imamura M, Masaki T. A novel nonmuscle alpha-actinin. Purification and characterization of chicken lung alpha-actinin. J Biol Chem. 1992;267:25927-33 pubmed
    ..This indicates that the 115-kDa protein is distinct from other nonmuscle alpha-actinins by its Ca2+ sensitivity. ..
  32. Shimada H, Taira M, Yamada K, Iizasa T, Tatibana M. Structure of the rat PRPS1 gene encoding phosphoribosylpyrophosphate synthetase subunit I. J Biol Chem. 1990;265:3956-60 pubmed
    ..A comparison of the promoter region for PRPS1 with those of other housekeeping genes revealed a homology resembling that of the beta-actin gene. ..
  33. Nishikawa S, Fujiwara K, Kitamura H. Formation of the tooth enamel rod pattern and the cytoskeletal organization in secretory ameloblasts of the rat incisor. Eur J Cell Biol. 1988;47:222-32 pubmed
    ..These observations suggest that the cytoskeletal organization in the ameloblast is involved in the formation of the enamel matrix pattern in the rat incisor...
  34. Koyama H, Kurokawa T, Nonami T, Nakao A, Sugiyama S, Murakami T, et al. Increases in the mitochondrial DNA replication and transcription in the remnant liver of rats. Biochem Biophys Res Commun. 1998;243:858-61 pubmed
  35. Nashida T, Yoshie S, Imai A, Shimomura H. Co-localization of rab4 with endocytosis-related proteins in the rat parotid glands. Arch Histol Cytol. 2003;66:45-52 pubmed
    ..Rab5A immunoreactivity was distributed all around the cytoplasm. These findings suggested that Rab4 participates in endocytosis at the apical membrane of parotid glands. ..
  36. Miki M, Kouyama T. Domain motion in actin observed by fluorescence resonance energy transfer. Biochemistry. 1994;33:10171-7 pubmed
    ..In G-actin, the mean distance between probes was 2.79 nm with a full width at half-maximum of 3.91 nm, indicating a large number of conformational substates in solution.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  37. Miki H, Miura K, Takenawa T. N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases. EMBO J. 1996;15:5326-35 pubmed
    ..Collectively, we conclude that N-WASP transmits signals from tyrosine kinases to cause a polarized rearrangement of cortical actin filaments dependent on PIP2. ..
  38. Fukui Y, Masuda H, Takagi M, Takahashi K, Kiyokane K. The presence of h2-calponin in human keratinocyte. J Dermatol Sci. 1997;14:29-36 pubmed
    ..We demonstrated the presence of h2-calponin in human keratinocytes, and it might play a role in the structural organization of actin cytoskeleton at the cytoplasmic region of cell-to-cell junctions of keratinocytes. ..
  39. Kumai T, Asoh K, Tateishi T, Tanaka M, Watanabe M, Shimizu H, et al. Involvement of tyrosine hydroxylase up regulation in dexamethasone-induced hypertension of rats. Life Sci. 2000;67:1993-9 pubmed
    ..alpha-Methyl-p-tyrosine prevented the DEX-induced blood pressure increase. These results suggest that the catecholamine synthetic pathway may be involved in DEX-induced hypertension. ..
  40. Amano T, Tanabe K, Eto T, Narumiya S, Mizuno K. LIM-kinase 2 induces formation of stress fibres, focal adhesions and membrane blebs, dependent on its activation by Rho-associated kinase-catalysed phosphorylation at threonine-505. Biochem J. 2001;354:149-59 pubmed
    ..These results suggest that LIMK2 functions downstream of the Rho-ROCK signalling pathway and plays a role in reorganization of actin filaments and membrane structures, by phosphorylating cofilin/ADF proteins. ..
  41. Ozaki Kuroda K, Nakanishi H, Ohta H, Tanaka H, Kurihara H, Mueller S, et al. Nectin couples cell-cell adhesion and the actin scaffold at heterotypic testicular junctions. Curr Biol. 2002;12:1145-50 pubmed
    ..These results indicate that the nectin-afadin system plays essential roles in coupling cell-cell adhesion and the cortical actin scaffold at SspJs and in subsequent sperm morphogenesis. ..
  42. Nakamura F, Mino T, Yamamoto J, Naka M, Tanaka T. Identification of the regulatory site in smooth muscle calponin that is phosphorylated by protein kinase C. J Biol Chem. 1993;268:6194-201 pubmed
    ..Thus Thr184 is the preferred site of phosphorylation and is functionally the most important of the sites phosphorylated by protein kinase C in smooth muscle calponin. ..
  43. Wakabayashi Y, Takahashi Y, Kikkawa Y, Okano H, Mishima Y, Ushiki T, et al. A novel type of myosin encoded by the mouse deafness gene shaker-2. Biochem Biophys Res Commun. 1998;248:655-9 pubmed
    ..This suggests that the novel myosin gene is a strong candidate for DFNB3. ..
  44. Suzuki T, Mimuro H, Suetsugu S, Miki H, Takenawa T, Sasakawa C. Neural Wiskott-Aldrich syndrome protein (N-WASP) is the specific ligand for Shigella VirG among the WASP family and determines the host cell type allowing actin-based spreading. Cell Microbiol. 2002;4:223-33 pubmed
    ..Thus, our findings demonstrate that N-WASP is a specific ligand of VirG, which determines the host cell type allowing actin-based spreading of Shigella. ..
  45. Zhang H, Shinmyo Y, Hirose A, Mito T, Inoue Y, Ohuchi H, et al. Extrachromosomal transposition of the transposable element Minos in embryos of the cricket Gryllus bimaculatus. Dev Growth Differ. 2002;44:409-17 pubmed
    ..These results strongly support the use of Minos transposons marked with the GbA3/4 promoter-eGFP for the genetic transformation of this emerging model insect species. ..
  46. Takayama M, Noguchi T, Yamashiro S, Mabuchi I. Microtuble organization in Xenopus eggs during the first cleavage and its role in cytokinesis. Cell Struct Funct. 2002;27:163-71 pubmed
    ..These results suggest that the astral microtubules play an important role in controlling the formation of the contractile ring in Xenopus eggs. ..
  47. Yoshiji H, Kuriyama S, Noguchi R, Ikenaka Y, Yoshii J, Yanase K, et al. Amelioration of liver fibrogenesis by dual inhibition of PDGF and TGF-beta with a combination of imatinib mesylate and ACE inhibitor in rats. Int J Mol Med. 2006;17:899-904 pubmed
    ..Since both agents are widely used in clinical practice, this combination therapy may provide a new strategy against liver fibrosis in the future. ..
  48. Yokoyama K, Kaji H, Nishimura K, Miyaji M. The role of microfilaments and microtubules in apical growth and dimorphism of Candida albicans. J Gen Microbiol. 1990;136:1067-75 pubmed
    ..Our results show that cytoplasmic microtubules are not essential for the elongation of filamentous cell tips but that microfilaments are apparently essential for this process...
  49. Iida K, Moriyama K, Matsumoto S, Kawasaki H, Nishida E, Yahara I. Isolation of a yeast essential gene, COF1, that encodes a homologue of mammalian cofilin, a low-M(r) actin-binding and depolymerizing protein. Gene. 1993;124:115-20 pubmed
    ..Gene disruption and tetrad analysis showed that gene COF1 is essential for yeast cell growth. Expression of the cDNA of porcine Cof or destrin (Des), the latter a Cof-related protein, complemented the cof1 null allele in yeast cells. ..
  50. Kurosaka D, Muraki Y, Inoue M, Katsura H. TGF-beta 2 increases alpha-smooth muscle actin expression in bovine retinal pigment epithelial cells. Curr Eye Res. 1996;15:1144-7 pubmed
    ..TGF-beta 2 increased the ratio of positive cells dose-dependently (p < 0.0001), while a neutralizing antibody against TGF-beta 2 blocked this effect. TGF-beta 2 induced expression of alpha-SMA in bovine RPE cells. ..
  51. Yokomori H. New insights into the dynamics of sinusoidal endothelial fenestrae in liver sinusoidal endothelial cells. Med Mol Morphol. 2008;41:1-4 pubmed publisher
    ..Currently, the majority of fenestral studies are focused on finding ways to increase the liver sieve's porosity, which is reduced through pathological mechanisms. ..
  52. Kyozuka K, Chun J, Puppo A, Gragnaniello G, Garante E, Santella L. Actin cytoskeleton modulates calcium signaling during maturation of starfish oocytes. Dev Biol. 2008;320:426-35 pubmed publisher
    ..Our results suggest that the cortical actin cytoskeleton of starfish oocytes plays critical roles both in generating Ca2+ signals and in regulating cortical granule exocytosis...
  53. Matsumura S, Sakurai K, Shinomiya T, Fujitani N, Key K, Ohashi M. Biochemical and immunohistochemical characterization of the isoforms of myosin and actin in human placenta. Placenta. 2011;32:347-55 pubmed publisher
    ..The vascular tissue appears to be composed of both smooth muscle-type and nonmuscle-type isoforms of contractile proteins. ..
  54. Maruyama Y, Ebihara T, Nishiyama H, Suga M, Sato C. Immuno EM-OM correlative microscopy in solution by atmospheric scanning electron microscopy (ASEM). J Struct Biol. 2012;180:259-70 pubmed publisher
    ..Based on this work, ASEM correlative microscopy promises to allow the dynamics of various protein complexes to be investigated in the near future. ..
  55. Daimon E, Shibukawa Y, Wada Y. Calponin 3 regulates stress fiber formation in dermal fibroblasts during wound healing. Arch Dermatol Res. 2013;305:571-84 pubmed publisher
    ..These findings indicate that CNN3 participates in actin stress fiber remodeling, which is required for cell motility and contraction of dermal fibroblasts in the wound healing process. ..
  56. Atomi Y, Yamada S, Nishida T. Early changes of alpha B-crystallin mRNA in rat skeletal muscle to mechanical tension and denervation. Biochem Biophys Res Commun. 1991;181:1323-30 pubmed
    ..Based upon these Northern blot analysis of alpha B-crystallin, nerve innervation and external load on muscle are essential regulatory factors on the expression of the mRNA of alpha B-crystallin in rat skeletal muscle. ..
  57. Kambe F, Tsukahara S, Kato T, Seo H. The POU-domain protein Oct-1 is widely expressed in adult rat organs. Biochim Biophys Acta. 1993;1171:307-10 pubmed
    ..Our results show that the POU-domain of Oct-1 has been highly conserved during vertebrate evolution and that Oct-1 mRNA is widely expressed in various organs of adult rat. ..
  58. Yoshiyama M, Takeuchi K, Omura T, Izutani S, Nakamura Y, Akioka K, et al. Effect of diltiazem on cardiac remodeling in rats assessed by Doppler echocardiography and mRNA expression. Cardiovasc Drugs Ther. 1999;13:249-58 pubmed
    ..In conclusion, diltiazem prevents cardiac dysfunction and morphological change due to left ventricular remodeling after experimental myocardial infarction. ..
  59. Hirota T, Morisaki T, Nishiyama Y, Marumoto T, Tada K, Hara T, et al. Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor. J Cell Biol. 2000;149:1073-86 pubmed
    ..These findings suggest that h-warts/LATS1 and zyxin play a crucial role in controlling mitosis progression by forming a regulatory complex on mitotic apparatus. ..
  60. Kasahara T, Miyazaki T, Nitta H, Ono A, Miyagishima T, Nagao T, et al. Evaluation of methods for duration of preservation of RNA quality in rat liver used for transcriptome analysis. J Toxicol Sci. 2006;31:509-19 pubmed
  61. Koike S, Keino Masu K, Masu M. Deficiency of autotaxin/lysophospholipase D results in head cavity formation in mouse embryos through the LPA receptor-Rho-ROCK pathway. Biochem Biophys Res Commun. 2010;400:66-71 pubmed publisher
    ..These results reveal the signal transduction defects that underlie the abnormalities in Enpp2(-/-) embryos. ..
  62. Obata Y, Nishino T, Kushibiki T, Tomoshige R, Xia Z, Miyazaki M, et al. HSP47 siRNA conjugated with cationized gelatin microspheres suppresses peritoneal fibrosis in mice. Acta Biomater. 2012;8:2688-96 pubmed publisher
    ..Additionally, RNA interference combined with CGMs as a drug-delivery system may lead to new strategies for knocking down specific genes in vivo. ..
  63. Shono M, Yoshioka R, Chatani Y, Hirai Y. Ectopic expression of syntaxin3 affects behaviors of B16 melanoma by controlling actin dynamics. Cell Struct Funct. 2013;38:97-107 pubmed
    ..This t-SNARE protein may act as a regulator of the actin dynamics, rather than a direct vesicle fusion mediator, to determine the fundamental properties of melanocytes. ..
  64. Kanazawa T, Nakamura S, Momoi M, Yamaji T, Takematsu H, Yano H, et al. Inhibition of cytokinesis by a lipid metabolite, psychosine. J Cell Biol. 2000;149:943-50 pubmed
  65. Watanabe S, De Zan T, Ishizaki T, Yasuda S, Kamijo H, Yamada D, et al. Loss of a Rho-regulated actin nucleator, mDia2, impairs cytokinesis during mouse fetal erythropoiesis. Cell Rep. 2013;5:926-32 pubmed publisher
    ..They also demonstrate that cytokinesis and enucleation utilize different mechanisms. ..
  66. Zu Y, Shigesada K, Nishida E, Kubota I, Kohno M, Hanaoka M, et al. 65-kilodalton protein phosphorylated by interleukin 2 stimulation bears two putative actin-binding sites and two calcium-binding sites. Biochemistry. 1990;29:8319-24 pubmed
    ..These results suggest that p65 belongs to actin-binding proteins. ..
  67. Emori Y, Saigo K. Calpain localization changes in coordination with actin-related cytoskeletal changes during early embryonic development of Drosophila. J Biol Chem. 1994;269:25137-42 pubmed
    ..These results indicate that calpain is involved in the dynamic changes in the embryonic cytoskeleton, especially actin-related structures, during early embryogenesis prior to cellularization. ..
  68. Kiwaki K, Kanegae Y, Saito I, Komaki S, Nakamura K, Miyazaki J, et al. Correction of ornithine transcarbamylase deficiency in adult spf(ash) mice and in OTC-deficient human hepatocytes with recombinant adenoviruses bearing the CAG promoter. Hum Gene Ther. 1996;7:821-30 pubmed
    ..Thus, the adenoviral vector with an efficient promoter such as CAG, can be given further consideration for possible gene therapy in humans with OTC deficiency. ..
  69. Ikeda T, Sawada N, Satoh M, Mori M. Induction of tyrosine aminotransferase of primary cultured rat hepatocytes depends on the organization of microtubules. J Cell Physiol. 1998;175:41-9 pubmed
    ..These studies suggest that the organization of cytoplasmic microtubules may participate in the shape-related regulation of cell function. ..
  70. Watanabe N, Kato T, Fujita A, Ishizaki T, Narumiya S. Cooperation between mDia1 and ROCK in Rho-induced actin reorganization. Nat Cell Biol. 1999;1:136-43 pubmed
    ..Thus Rho may induce the formation of different actin structures affected by the balance between mDia1 and ROCK signalling. ..
  71. Matsumoto K, Yamamoto T, Hisayoshi T, Asano G. Intravenous leiomyomatosis of the uterus with multiple pulmonary metastases associated with large bullae-like cyst formation. Pathol Int. 2001;51:396-401 pubmed
    ..From these findings, an intravenous leiomyomatosis associated with multiple pulmonary metastases was diagnosed. ..
  72. Muramatsu Y, Lejukole H, Taniguchi Y, Konfortov B, Yamada T, Yasue H, et al. Chromosomal assignments of expressed sequence tags for ACTG1, AHSG, COL1A1, GNAS1, and RPLP1 expressed abundantly in the bovine foetus. Anim Genet. 2002;33:230-1 pubmed
  73. Hiruma H, Katakura T, Takahashi S, Ichikawa T, Kawakami T. Glutamate and amyloid beta-protein rapidly inhibit fast axonal transport in cultured rat hippocampal neurons by different mechanisms. J Neurosci. 2003;23:8967-77 pubmed
    ..Full-length Abeta may be effective when it represents a structure in which these active residues can access the cell membrane. Our results may provide insight into the early pathogenetic mechanisms of AD. ..
  74. Oyama Y, Kawai Kowase K, Sekiguchi K, Sato M, Sato H, Yamazaki M, et al. Homeobox protein Hex facilitates serum responsive factor-mediated activation of the SM22alpha gene transcription in embryonic fibroblasts. Arterioscler Thromb Vasc Biol. 2004;24:1602-7 pubmed
    ..These findings will provide the clue for understanding the mechanisms by which bone marrow-derived SMC precursor cells undergo differentiation. ..
  75. Morita M, Nakamura M. Dynamic behavior of plastids related to environmental response. Curr Opin Plant Biol. 2012;15:722-8 pubmed publisher
  76. Kubota Y, Tsuyama K, Takabayashi Y, Haruta N, Maruyama R, Iida N, et al. The PAF1 complex is involved in embryonic epidermal morphogenesis in Caenorhabditis elegans. Dev Biol. 2014;391:43-53 pubmed publisher
    ..Thus, although the PAF1C is universally expressed in C. elegans embryos, its epidermal function is crucial for the viability of this animal. ..
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