Experts and Doctors on acetyl coa c acyltransferase in United States
Locale: United States
Topic: acetyl coa c acyltransferase
MacInnes A, Fairman D, Binding P, Rhodes J, Wyatt M, Phelan A, et al
. The antianginal agent trimetazidine does not exert its functional benefit via inhibition of mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ Res. 2003;93:e26-32 pubmed
..The full text of this article is available online at http://www.circresaha.org. ..
Nissen S, Tuzcu E, Brewer H, Sipahi I, Nicholls S, Ganz P, et al
. Effect of ACAT inhibition on the progression of coronary atherosclerosis. N Engl J Med. 2006;354:1253-63 pubmed
..ACAT inhibition is not an effective strategy for limiting atherosclerosis and may promote atherogenesis. (ClinicalTrials.gov number, NCT00268515.). ..
Nicholls S, Sipahi I, Schoenhagen P, Wisniewski L, Churchill T, Crowe T, et al
. Intravascular ultrasound assessment of novel antiatherosclerotic therapies: rationale and design of the Acyl-CoA:Cholesterol Acyltransferase Intravascular Atherosclerosis Treatment Evaluation (ACTIVATE) Study. Am Heart J. 2006;152:67-74 pubmed
..In this study, IVUS will be used to assess whether ACAT inhibition modifies progression of atherosclerotic plaque. ..
Gu L, Zhang G, Kombu R, Allen F, Kutz G, Brewer W, et al
. Parenteral and enteral metabolism of anaplerotic triheptanoin in normal rats. II. Effects on lipolysis, glucose production, and liver acyl-CoA profile. Am J Physiol Endocrinol Metab. 2010;298:E362-71 pubmed publisher
..Our data suggest that triheptanoin, administered either intravenously or intraduodenally, could be used for intensive care and nutritional support of metabolically decompensated long-chain fatty acid oxidation disorders. ..
Korotkova N, Lidstrom M. Connection between poly-beta-hydroxybutyrate biosynthesis and growth on C(1) and C(2) compounds in the methylotroph Methylobacterium extorquens AM1. J Bacteriol. 2001;183:1038-46 pubmed
..These results suggest that beta-hydroxybutyryl-CoA is an intermediate in the unknown pathway that converts acetyl-CoA to glyoxylate in methylotrophs and Streptomyces spp...
Afitlhile M, Fukushige H, Nishimura M, Hildebrand D. A defect in glyoxysomal fatty acid beta-oxidation reduces jasmonic acid accumulation in Arabidopsis. Plant Physiol Biochem. 2005;43:603-9 pubmed
..Thus, reduced levels of JA in the wounded tissues of the mutant were attributed to the defect in a thiolase protein...