Experts and Doctors on genomic instability in Copenhagen, Capital Region, Denmark

Summary

Locale: Copenhagen, Capital Region, Denmark
Topic: genomic instability

Top Publications

  1. Sørensen C, Syljuåsen R, Lukas J, Bartek J. ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage. Cell Cycle. 2004;3:941-5 pubmed
    ..DNA damage further activates and switches this pathway from its constitutively operating "surveillance mode" compatible with DNA replication into an "emergency" checkpoint response. ..
  2. Beck H, Nähse Kumpf V, Larsen M, O Hanlon K, Patzke S, Holmberg C, et al. Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption. Mol Cell Biol. 2012;32:4226-36 pubmed
  3. Hornstrup L, Frikke Schmidt R, Nordestgaard B, Tybjærg Hansen A. Genetic stabilization of transthyretin, cerebrovascular disease, and life expectancy. Arterioscler Thromb Vasc Biol. 2013;33:1441-7 pubmed publisher
    ..002-0.05). These results are compatible with an association between genetic stabilization of transthyretin and decreased risk of cerebrovascular disease, and with increased life expectancy in the general population. ..
  4. Køhler J, Jørgensen M, Beinoraité G, Thorsen M, Thon G. Concerted action of the ubiquitin-fusion degradation protein 1 (Ufd1) and Sumo-targeted ubiquitin ligases (STUbLs) in the DNA-damage response. PLoS ONE. 2013;8:e80442 pubmed publisher
    ..Broader functional relationships between Ufd1 and STUbLs conceivably affect numerous cellular processes beyond the DDR...
  5. Kriegenburg F, Jakopec V, Poulsen E, Nielsen S, Roguev A, Krogan N, et al. A chaperone-assisted degradation pathway targets kinetochore proteins to ensure genome stability. PLoS Genet. 2014;10:e1004140 pubmed publisher
  6. Schimmel J, Eifler K, Sigurðsson J, Cuijpers S, Hendriks I, Verlaan de Vries M, et al. Uncovering SUMOylation dynamics during cell-cycle progression reveals FoxM1 as a key mitotic SUMO target protein. Mol Cell. 2014;53:1053-66 pubmed publisher
    ..Cells deficient for FoxM1 SUMOylation showed increased levels of polyploidy. Our findings contribute to understanding the role of SUMOylation during cell-cycle progression. ..
  7. Juhl M, Tratwal J, Follin B, Søndergaard R, Kirchhoff M, Ekblond A, et al. Comparison of clinical grade human platelet lysates for cultivation of mesenchymal stromal cells from bone marrow and adipose tissue. Scand J Clin Lab Invest. 2016;76:93-104 pubmed publisher
    ..The ideal cell culture medium should be devoid of any animal derived components. We have evaluated whether human Platelet Lysate (hPL) could be an attractive alternative to animal supplements...
  8. Toledo L, Neelsen K, Lukas J. Replication Catastrophe: When a Checkpoint Fails because of Exhaustion. Mol Cell. 2017;66:735-749 pubmed publisher
  9. Liu D, Keijzers G, Rasmussen L. DNA mismatch repair and its many roles in eukaryotic cells. Mutat Res. 2017;773:174-187 pubmed publisher
    ..Although the molecular mechanism of MMR in the eukaryotic cell is still not completely understood, increased used of single-molecule analyses in the future may yield new insight into these unsolved questions. ..

More Information

Publications11

  1. Bahl M, Hansen L, Sørensen S. Persistence mechanisms of conjugative plasmids. Methods Mol Biol. 2009;532:73-102 pubmed publisher
    ..Finally, various molecular adaptations of plasmids to better match the genetic background of their bacterial host cell will be described. ..
  2. Toledo L, Altmeyer M, Rask M, Lukas C, Larsen D, Povlsen L, et al. ATR prohibits replication catastrophe by preventing global exhaustion of RPA. Cell. 2013;155:1088-103 pubmed publisher
    ..Because cancer cells commonly feature intrinsically high replication stress, this study also provides a molecular rationale for their hypersensitivity to ATR inhibitors. ..