Experts and Doctors on molecular weight in Hangzhou, Zhejiang Sheng, China


Locale: Hangzhou, Zhejiang Sheng, China
Topic: molecular weight

Top Publications

  1. Zhou H, Jiang H, Yao T, Zeng S. Fragmentation study on the phenolic alkaloid neferine and its analogues with anti-HIV activities by electrospray ionization tandem mass spectrometry with hydrogen/deuterium exchange and its application for rapid identification of in vitro microsomal . Rapid Commun Mass Spectrom. 2007;21:2120-8 pubmed
    ..This is critical for screening and development of phenolic bisbenzyltetrahydroisoquinoline alkaloids with anti-HIV activities such as neferine and its analogues isoliensinine and liensinine. ..
  2. Zhang Y, Chen J, Lv Z, Nie Z, Zhang X, Wu X. Can 29kDa rhGM-CSF expressed by silkworm pupae bioreactor bring into effect as active cytokine through orally administration?. Eur J Pharm Sci. 2006;28:212-23 pubmed
    ..These results proved that BmrhGM-CSF, a 29kDa glycoprotein expressed by Silkworm pupae bioreactor, could bring into the effect as active cytokine through oral administration. ..
  3. Yunfei L, Haibin Q, Yiyu C. Identification of major constituents in the traditional Chinese medicine "QI-SHEN-YI-QI" dropping pill by high-performance liquid chromatography coupled with diode array detection-electrospray ionization tandem mass spectrometry. J Pharm Biomed Anal. 2008;47:407-12 pubmed publisher
    ..The proposed method contributes to the quality control of "QI-SHEN-YI-QI" dropping pill. ..
  4. He P, Zhang A, Wang X, Qu L, Li G, Li Y, et al. Structure elucidation and antioxidant activity of a novel polysaccharide from Polyporus umbellatus sclerotia. Int J Biol Macromol. 2016;82:411-7 pubmed publisher
    ..The antioxidant activity assay in vitro showed that PUP60S2 exerted a significant scavenging effect on DPPH, hydroxyl radical and superoxide radical in a dose-dependent manner. ..
  5. Zhu L, Zhang X, Xu L, Du C, Zhu B, Xu Y. Improved protein-adsorption resistance of polyethersulfone membranes via surface segregation of ultrahigh molecular weight poly(styrene-alt-maleic anhydride). Colloids Surf B Biointerfaces. 2007;57:189-97 pubmed
  6. Gong Y, Zhou Q, Gao C, Shen J. In vitro and in vivo degradability and cytocompatibility of poly(l-lactic acid) scaffold fabricated by a gelatin particle leaching method. Acta Biomater. 2007;3:531-40 pubmed
    ..The regions occupied initially by PLLA scaffold were filled later by collagen type II secreted by the chondrocytes, but with no evident basophilic proteoglycan. ..
  7. Du Y, Weng Q, Yuan H, Hu F. Synthesis and antitumor activity of stearate-g-dextran micelles for intracellular doxorubicin delivery. ACS Nano. 2010;4:6894-902 pubmed publisher
    ..In vivo antitumor activity results showed that Dex-SA/DOX micelles treatments effectively suppressed the tumor growth and reduced the toxicity against animal body compared with commercial doxorubicin injection. ..
  8. Zou S, Xie L, Liu Y, Kaleem I, Zhang G, Li C. N-linked glycosylation influences on the catalytic and biochemical properties of Penicillium purpurogenum ?-d-glucuronidase. J Biotechnol. 2012;157:399-404 pubmed publisher
  9. He L, Ji P, Cheng J, Wang Y, Qian H, Li W, et al. Structural characterization and immunostimulatory activity of a novel protein-bound polysaccharide produced by Hirsutella sinensis Liu, Guo, Yu & Zeng. Food Chem. 2013;141:946-53 pubmed publisher
    ..In terms of the pro-inflammatory cytokines assay (NO, TNF-?, IL-1? and NF-?B) using murine macrophages cell line (RAW264.7), HS002-II exhibited significant immunomodulatory activity by stimulating the I?B-NF-?B pathway. ..

More Information


  1. Jia Z, Shen D, Xu W. Synthesis and antibacterial activities of quaternary ammonium salt of chitosan. Carbohydr Res. 2001;333:1-6 pubmed
    ..Their antibacterial activities is increased as the concentration of acetic acid is increased. It was also found that the antibacterial activity of quaternized chitosan against E. coli is stronger than that of chitosan. ..
  2. Qiu M, Jiang H, Ren G, Huang J, Wang X. Effect of chitosan coatings on postharvest green asparagus quality. Carbohydr Polym. 2013;92:2027-32 pubmed publisher
  3. Yalin W, Yuanjiang P, Cuirong S. Isolation, purification and structural investigation of a water-soluble polysaccharide from Solanum lyratum Thunb. Int J Biol Macromol. 2005;36:241-5 pubmed
    ..The anomeric NMR and IR spectra measurements confirmed that the sugar residues were beta-glycosidically linked. ..
  4. Zheng Q, Chen J, Nie Z, Lv Z, Wang D, Zhang Y. Expression, purification and characterization of a three-domain Kazal-type inhibitor from silkworm pupae (Bombyx mori). Comp Biochem Physiol B Biochem Mol Biol. 2007;146:234-40 pubmed
    ..35 nM and the inhibitor seemed to form a 1:1 complex with subtilisin A. This is a first description of the structure and characterization of Kazal-type inhibitor with three domains cloned from silkworm pupae, B. mori. ..
  5. Dou J, Zhang H, Liu X, Zhang M, Zhai G. Preparation and evaluation in vitro and in vivo of docetaxel loaded mixed micelles for oral administration. Colloids Surf B Biointerfaces. 2014;114:20-7 pubmed publisher
    ..52 times compared to that of DTX solution. The current results encourage further development of DTX mixed polymeric micelles as the oral drug delivery system. ..
  6. Huang H, Yu H, Tang G, Wang Q, Li J. Low molecular weight polyethylenimine cross-linked by 2-hydroxypropyl-gamma-cyclodextrin coupled to peptide targeting HER2 as a gene delivery vector. Biomaterials. 2010;31:1830-8 pubmed publisher
  7. Jia J, Zhou Y, Lu J, Chen A, Li Y, Zheng G. Enzymatic hydrolysis of Alaska pollack (Theragra chalcogramma) skin and antioxidant activity of the resulting hydrolysate. J Sci Food Agric. 2010;90:635-40 pubmed publisher
    ..The aims of this study were to prepare peptides from Alaska pollack (Theragra chalcogramma) skin by enzymatic hydrolysis and to evaluate the antioxidant activity of the resulting hydrolysate...
  8. Zhou J, Wang J, Chen J, Wu J, Gong H, Teng Q, et al. Cloning, in vitro expression and bioactivity of duck interleukin-2. Mol Immunol. 2005;42:589-98 pubmed publisher
  9. Shi F, Xu Z, Cen P. Efficient production of poly-gamma-glutamic acid by Bacillus subtilis ZJU-7. Appl Biochem Biotechnol. 2006;133:271-82 pubmed
    ..The average molecular mass of gamma-PGA produced was about 1.24 x 106 Daltons. B. subtilis ZJU-7 is genetically stable and can synthesize levan instead of gamma-PGA without the addition of L-glutamic acid to the medium. ..
  10. Wu Y, Sun H, Qin F, Pan Y, Sun C. Effect of various extracts and a polysaccharide from the edible mycelia of Cordyceps sinensis on cellular and humoral immune response against ovalbumin in mice. Phytother Res. 2006;20:646-52 pubmed
    ..05 or p < 0.01). OVA-specific IgG, IgG1 and IgG2b antibody levels in serum were significantly enhanced by these extracts and PS compared with the OVA control group (p < 0.05, p < 0.01 or p < 0.001). ..
  11. Wang D, Zhang C. HearSNPV orf83 encodes a late, nonstructural protein with an active chitin-binding domain. Virus Res. 2006;117:237-43 pubmed
    ..8 kDa. The protein was first detected in the cytoplasm of infected HzAM1 cells at 12h p.i., and was transported later into the nucleus during infection. ..
  12. Wu N, Ye X, Guo X, Liao N, Yin X, Hu Y, et al. Depolymerization of fucosylated chondroitin sulfate from sea cucumber, Pearsonothuria graeffei, via 60Co irradiation. Carbohydr Polym. 2013;93:604-14 pubmed publisher
    ..Based on the collective findings, we propose that these fragments are potentially applicable as antithrombotic agents with reduced bleeding risk relative to native fCS-Pg. ..
  13. Zhou L, Lai Z, Lu M, Gong X, Xie Y. Expression and hydroxylamine cleavage of thymosin alpha 1 concatemer. J Biomed Biotechnol. 2008;2008:736060 pubmed publisher
    ..This study provides a description of the preparation of a bioactive Talpha1, which may prove useful in future biomedical research...
  14. Yu P, Chen Y. Purification and characterization of a novel neutral and heat-tolerant phytase from a newly isolated strain Bacillus nealsonii ZJ0702. BMC Biotechnol. 2013;13:78 pubmed publisher
    ..These properties suggest that this phytase is a suitable alternative to fungal phytases for the hydrolysis of phytic acid and phytates in food and feed processing industries. ..
  15. Zhang X, Zhang M, Zheng C, Liu J, Hu H. Identification of two hsp90 genes from the marine crab, Portunus trituberculatus and their specific expression profiles under different environmental conditions. Comp Biochem Physiol C Toxicol Pharmacol. 2009;150:465-73 pubmed publisher
    ..These results suggested there were at least two Hsp90s in P. trituberculatus, which played differing roles in physiological and stressful conditions. ..
  16. He L, Ji P, Gong X, Li W, Cheng J, Qian H, et al. Physico-chemical characterization, antioxidant and anticancer activities in vitro of a novel polysaccharide from Melia toosendan Sieb. Et Zucc fruit. Int J Biol Macromol. 2011;49:422-7 pubmed publisher
    ..It is strongly evidenced that pMTPS-3 purified from the crude polysaccharides of Melia toosendan Sieb. Et Zucc could be explored as a potential antioxidant and therapeutics...
  17. Shao P, Chen M, Pei Y, Sun P. In intro antioxidant activities of different sulfated polysaccharides from chlorophytan seaweeds Ulva fasciata. Int J Biol Macromol. 2013;59:295-300 pubmed publisher
    ..The antioxidant activities of UFP were not a function of a single factor but a combination of several factors...
  18. Wang J, Sun Z, Zhou Y, Wang Q, Ye J, Chen Z, et al. Screening of a xylanase clone from a fosmid library of rumen microbiota in Hu sheep. Anim Biotechnol. 2012;23:156-73 pubmed publisher
    ..The C-terminal helped increase the stability of the xylanase but decreased the activity to some degree. The C-terminal ?-sandwich could bind avicel, but no conserved domain could be found. It may be a novel carbohydrate-binding module...
  19. Wang Y, Li L, Li B, Wu G, Tang Q, Ibrahim M, et al. Action of chitosan against Xanthomonas pathogenic bacteria isolated from Euphorbia pulcherrima. Molecules. 2012;17:7028-41 pubmed publisher
    ..Overall, this study showed that membrane and biofilm play an important role in the antibacterial mechanism of chitosan...
  20. Wu S, Zhang H, Yu X, Chen J. Identification and cloning of a gene encoding dichloromethane dehalogenase from a methylotrophic bacterium, Bacillus circulans WZ-12 CCTCC M 207006. Bioprocess Biosyst Eng. 2009;32:845-52 pubmed publisher
    ..strain DM11. The Michaelis-Menten constant of DCM dehalogenase was markedly lower than that of standard DCM dehalogenases...
  21. Zhao L, Ma Z, Zhu J, Yu X, Weng D. Characterization of polysaccharide from Astragalus radix as the macrophage stimulator. Cell Immunol. 2011;271:329-34 pubmed publisher
    ..Blocking NF-?B with specific inhibitor resulted in decreased levels of NO and TNF-?. The results suggested that APS possess potent immunomodulatory activity by stimulating macrophage and could be used as an immunotherapeutic adjuvant...
  22. Wang X, Zhang B, Xu H, Cui Y, Xu Y, Zhang M, et al. ODV-associated proteins of the Pieris rapae granulovirus. J Proteome Res. 2011;10:2817-27 pubmed publisher
  23. Chen Q, Yan C, Yan Q, Feng L, Chen J, Qian K. The novel MGC13096 protein is correlated with proliferation. Cell Biochem Funct. 2008;26:141-5 pubmed
  24. Wang Z, Ke B, Xu Z. Covalent immobilization of redox enzyme on electrospun nonwoven poly(acrylonitrile-co-acrylic acid) nanofiber mesh filled with carbon nanotubes: a comprehensive study. Biotechnol Bioeng. 2007;97:708-20 pubmed
    ..The effect of MWCNTs incorporation on another redox enzyme, peroxidase, was also studied and it was found that the activity increased by 68% in comparison of composite one with neat preparation. ..
  25. Chen J, Shi Y, Adams M, Zheng H, Qin B, Chen J. Characterisation of an isolate of Narcissus degeneration virus from Chinese narcissus (Narcissus tazetta var. chinensis). Arch Virol. 2007;152:441-8 pubmed
    ..Sequence comparisons and phylogenetic analysis showed that the Chinese virus was different from all previously sequenced potyviruses but distantly related to onion yellow dwarf and shallot yellow stripe viruses...
  26. Nie X, Shi B, Ding Y, Tao W. Preparation of a chemically sulfated polysaccharide derived from Grifola frondosa and its potential biological activities. Int J Biol Macromol. 2006;39:228-33 pubmed
  27. Quan H, Qiong Yao Y, Jiang S, Chang Yun X, Ze Jie L, Pu Ming H. Structural characterization and antioxidant activities of 2 water-soluble polysaccharide fractions purified from tea (Camellia sinensis) flower. J Food Sci. 2011;76:C462-71 pubmed publisher
  28. Zhang J, Zheng Y, Shen Y. Purification and characterization of 3-ketovalidoxylamine A C-N lyase produced by Stenotrophomonas maltrophilia. Appl Biochem Biotechnol. 2010;162:966-74 pubmed publisher
    ..The enzyme has C-N lyase activity and C-O lyase activity, and need 3-keto groups. The apparent K (m) value for p-nitrophenyl-3-ketovalidamine was 0.14 mM...
  29. He J, Ru Q, Dong D, SUN P. Chemical characteristics and antioxidant properties of crude water soluble polysaccharides from four common edible mushrooms. Molecules. 2012;17:4373-87 pubmed publisher
    ..The studied mushroom species could potentially be used in part of well-balanced diets and as a source of antioxidant compounds. ..
  30. Jin R, Lv Z, Chen Q, Quan Y, Zhang H, Li S, et al. Safety and immunogenicity of H5N1 influenza vaccine based on baculovirus surface display system of Bombyx mori. PLoS ONE. 2008;3:e3933 pubmed publisher
    ..375 mg/kg in rats and 3.2 mg/kg in cynomolgus monkeys. Our work showed the vaccine may be a candidate for a highly effective, cheap, and safe influenza vaccine for use in humans...
  31. Wang C, Yang J, Zhu L, Yan L, Lu D, Zhang Q, et al. Never deem lightly the "less harmful" low-molecular-weight PAH, NPAH, and OPAH - Disturbance of the immune response at real environmental levels. Chemosphere. 2017;168:568-577 pubmed publisher
    ..During infection, AhR ligands caused immunosuppression and this potency for TPAHs may be higher in AhR activator than that in AhR inactivator. ..
  32. Zhou J, Hu N, Wu Y, Pan Y, Sun C. Preliminary studies on the chemical characterization and antioxidant properties of acidic polysaccharides from Sargassum fusiforme. J Zhejiang Univ Sci B. 2008;9:721-7 pubmed publisher
    ..The results show that the antioxidant ability of SFPS-2 was higher than that of SFPS-1, probably correlating with the molecular weight and uronic acid content...
  33. Shi M, Chen Y, Huang F, Liu P, Zhou X, Chen X. Characterization of a novel gene encoding ankyrin repeat domain from Cotesia vestalis polydnavirus (CvBV). Virology. 2008;375:374-82 pubmed publisher
    ..The protein was confirmed to be present within the nuclear region in hemocytes of the parasitized P. xylostella larvae at 48 h p.p. using confocal laser scanning microscopy. ..
  34. Cao Y, Liao L, Xu X, Oren A, Wang C, Zhu X, et al. Characterization of alcohol dehydrogenase from the haloalkaliphilic archaeon Natronomonas pharaonis. Extremophiles. 2008;12:471-6 pubmed publisher
    ..0. Zn2+ significantly inhibited activity. The Km value for acetaldehyde was higher than that for ethanol. It was concluded that the physiological role of this enzyme is likely the catalysis of the oxidation of ethanol to acetaldehyde...
  35. Chen L, Chen J, Zhang H, Chen S. Complete nucleotide sequences of three dsRNA segments from Raphanus sativus-root cv. Yidianhong [corrected] with leaf yellow edge symptoms. Arch Virol. 2006;151:2077-83 pubmed publisher
    ..Taken together, these results along with those described in the previous report, suggest that more than one partitivirus was co-infecting radish leaves...