Experts and Doctors on alendronate in Hangzhou, Zhejiang Sheng, China

Summary

Locale: Hangzhou, Zhejiang Sheng, China
Topic: alendronate

Top Publications

  1. Ye Y, Hu S, Li L. Inhibition of farnesylpyrophosphate synthase prevents angiotensin II-induced hypertrophic responses in rat neonatal cardiomyocytes: involvement of the RhoA/Rho kinase pathway. FEBS Lett. 2009;583:2997-3003 pubmed publisher
    ..This study revealed that the inhibition of FPP synthase by alendronate reduces RhoA activation by diminishing geranylgeranylation which prevents Ang II-induced hypertrophic responses in neonatal cardiomyocytes. ..
  2. Li L, Chen G, Yang Y, Ye Y, Yao L, Hu S. Chronic inhibition of farnesyl pyrophosphate synthase attenuates cardiac hypertrophy and fibrosis in spontaneously hypertensive rats. Biochem Pharmacol. 2010;79:399-406 pubmed publisher
  3. Yang J, Zhu H, Chen G, Ye Y, Zhao C, Mou Y, et al. Inhibition of farnesyl pyrophosphate synthase attenuates angiotensin II-induced cardiac hypertrophy and fibrosis in vivo. Int J Biochem Cell Biol. 2013;45:657-66 pubmed publisher
    ..In conclusion, FPPS might play an important role in Ang II-induced cardiac hypertrophy and fibrosis in vivo, at least in part through RhoA, p-38 MAPK and TGF-?1. ..