Experts and Doctors on viral proteins in Tianjin, Tianjin Shi, China


Locale: Tianjin, Tianjin Shi, China
Topic: viral proteins

Top Publications

  1. Yang H, Liang L, Lin S, Jia S. Isolation and characterization of a virulent bacteriophage AB1 of Acinetobacter baumannii. BMC Microbiol. 2010;10:131 pubmed publisher
    ..In this study, we described the isolation and characterization of one virulent bacteriophage AB1 capable of specifically infecting A. baumannii...
  2. Li Y, Zhang C, Chen X, Yu J, Wang Y, Yang Y, et al. ICP34.5 protein of herpes simplex virus facilitates the initiation of protein translation by bridging eukaryotic initiation factor 2alpha (eIF2alpha) and protein phosphatase 1. J Biol Chem. 2011;286:24785-92 pubmed publisher
    ..We propose that herpes simplex virus protein ICP34.5 bridges PP1 and eIF2? via their binding motifs and thereby facilitates the protein synthesis and viral replication. ..
  3. Zhao X, Huang S, Zhao J, He X, Li E, Li H, et al. Characterization of phiCFP-1, a virulent bacteriophage specific for Citrobacter freundii. J Med Virol. 2016;88:895-905 pubmed publisher
    ..Comparative genomics and recombination analyzes revealed close genetic relatedness among phiCFP-1, phiYeO3-12/vB_YenP_AP5 (from Yersinia enterocolitica O3), and phiSG-JL2 (from Salmonella enterica)...
  4. Wang L, Bao B, Song G, Chen C, Zhang X, Lu W, et al. Discovery of unsymmetrical aromatic disulfides as novel inhibitors of SARS-CoV main protease: Chemical synthesis, biological evaluation, molecular docking and 3D-QSAR study. Eur J Med Chem. 2017;137:450-461 pubmed publisher
    ..The present research therefore has provided some meaningful guidance to design and identify anti-SARS drugs with totally new chemical structures. ..
  5. Wang J, Tan J, Zhang X, Guo H, Zhang Q, Guo T, et al. BFV activates the NF-kappaB pathway through its transactivator (BTas) to enhance viral transcription. Virology. 2010;400:215-23 pubmed publisher
    ..Together, this study suggests that BFV activates the NF-kappaB pathway through BTas to enhance viral transcription...
  6. Xuan C, Qiao W, Li J, Peng G, Liu M, Chen Q, et al. BTat, a trans-acting regulatory protein, contributes to bovine immunodeficiency virus-induced apoptosis. Cell Microbiol. 2008;10:31-40 pubmed
    ..In addition, these results uncover a novel role for BTat in regulating microtubule dynamics in addition to its conventional role in regulating gene transcription...
  7. Zhang C, Tang J, Xie J, Zhang H, Li Y, Zhang J, et al. A conserved domain of herpes simplex virus ICP34.5 regulates protein phosphatase complex in mammalian cells. FEBS Lett. 2008;582:171-6 pubmed
    ..5 and PP1. These results suggest that concerted action between the PP1 binding domain and the effector domain of ICP34.5 is crucial for eIF2alpha dephosphorylation and viral protein synthesis. ..
  8. Wang J, Tan J, Guo H, Zhang Q, Jia R, Xu X, et al. Bovine foamy virus transactivator BTas interacts with cellular RelB to enhance viral transcription. J Virol. 2010;84:11888-97 pubmed publisher
    ..Thus, this study demonstrates the existence of a positive-feedback circuit in which BFV utilizes the host's NF-?B pathway through the RelB protein for efficient viral transcription...
  9. Liu B, Dong S, Li G, Wang W, Liu X, Wang Y, et al. Structural Insight into Nucleoprotein Conformation Change Chaperoned by VP35 Peptide in Marburg Virus. J Virol. 2017;91: pubmed publisher
    ..Finally, we discussed the high conservation and critical role of the VP35 binding pocket and its potential use for therapeutic development. ..