Experts and Doctors on histones in Tianjin, Tianjin Shi, China


Locale: Tianjin, Tianjin Shi, China
Topic: histones

Top Publications

  1. Shan L, Li X, Liu L, Ding X, Wang Q, Zheng Y, et al. GATA3 cooperates with PARP1 to regulate CCND1 transcription through modulating histone H1 incorporation. Oncogene. 2014;33:3205-16 pubmed publisher
    ..Our results unveiled a molecular basis for the coordinated regulation between GATA3 and PARP1 in transcription activation, providing a mechanism for GATA3 in breast carcinogenesis. ..
  2. Zheng S, Sun M, Zhang K, Gu J, Guo Z, Tian S, et al. Profiling post-translational modifications of histones in neural differentiation of embryonic stem cells using liquid chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;1017-1018:36-44 pubmed publisher
    ..This study demonstrates that HPLC-MS-based quantitative proteomics has a considerable advantage on quantification of combinational PTMs and expands our understanding of HPTMs in the differentiation. ..
  3. Wu G, Wang N, Luo Y, Zhang Y, Wang P, Zhu Z, et al. Metabolic perturbation of epigenome by inhibiting S-adenosylhomocysteine hydrolase elicits senescence through DNA damage response in hepatoma cells. Tumour Biol. 2017;39:1010428317699117 pubmed publisher
    ..In conclusion, our study demonstrated that metabolic perturbation of chromatin status in oncogene-activated cancers could be an optional intervention to sensitize DNA damage response signaling. ..
  4. Hong W, Li J, Wang B, Chen L, Niu W, Yao Z, et al. Epigenetic involvement of Alien/ESET complex in thyroid hormone-mediated repression of E2F1 gene expression and cell proliferation. Biochem Biophys Res Commun. 2011;415:650-5 pubmed publisher
    ..Taken together, our data indicate that ESET is involved in TR?1-mediated transcription repression and provide a molecular basis of thyroid hormone-induced repression of proliferation. ..
  5. Dan J, Liu Y, Liu N, Chiourea M, Okuka M, Wu T, et al. Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing. Dev Cell. 2014;29:7-19 pubmed publisher
    ..Mechanistically, Rif1 interacts and stabilizes H3K9 methylation complex. Thus, Rif1 regulates telomere length homeostasis of ESCs by mediating heterochromatic silencing. ..
  6. Li X, Liu L, Yang S, Song N, Zhou X, Gao J, et al. Histone demethylase KDM5B is a key regulator of genome stability. Proc Natl Acad Sci U S A. 2014;111:7096-101 pubmed publisher
  7. Guo H, Chu Y, Wang L, Chen X, Chen Y, Cheng H, et al. PBX3 is essential for leukemia stem cell maintenance in MLL-rearranged leukemia. Int J Cancer. 2017;141:324-335 pubmed publisher
    ..Significantly, the differential expression of PBX3 in normal and malignant hematopoietic cells suggests PBX3 as a potential prognostic marker and therapeutic target for MLL-r leukemia. ..
  8. Sun L, Gao J, Dong X, Liu M, Li D, Shi X, et al. EB1 promotes Aurora-B kinase activity through blocking its inactivation by protein phosphatase 2A. Proc Natl Acad Sci U S A. 2008;105:7153-8 pubmed publisher
    ..These findings establish Aurora-B as an EB1-interacting protein and suggest that EB1 stimulates Aurora-B activity through antagonizing its dephosphorylation/inactivation by PP2A. ..
  9. Tian X, Xu J, Zhou H, Liu R, Chen J, Huang X. Thr 3 phosphorylated histone H3 concentrates at centromeric chromatin at metaphase. Biochem Biophys Res Commun. 2010;401:618-23 pubmed publisher
    ..These findings suggested that at metaphase Thr 3 phosphorylated histone H3 may also participate in kinetochore assembly to promote faithful chromosome segregation and serve as another recognition code for kinetochore proteins. ..

More Information


  1. Xuan C, Wang Q, Han X, Duan Y, Li L, Shi L, et al. RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene. Oncogene. 2013;32:3711-21 pubmed publisher
    ..Significantly, we showed that RBB suppresses cell proliferation and sensitizes cells to DNA damage-induced apoptosis. Our data indicate that RBB is a novel transcriptional repressor and an important regulator of p53 pathway. ..
  2. Si J, Yang J, Xue L, Yang C, Luo Y, Shi H, et al. Activation of NF-?B in basolateral amygdala is required for memory reconsolidation in auditory fear conditioning. PLoS ONE. 2012;7:e43973 pubmed publisher
    ..These findings indicate that NF-?B activity in the BLA is required for memory reconsolidation in AFC, suggesting that NF-?B might be a potential pharmacotherapy target for posttraumatic stress disorder. ..
  3. Xu C, Xu Y, Gursoy Yuzugullu O, Price B. The histone variant macroH2A1.1 is recruited to DSBs through a mechanism involving PARP1. FEBS Lett. 2012;586:3920-5 pubmed publisher
    ..These results reveal an unusual mechanism involving a direct association of macroH2A1.1 with PARylated chromatin which is critical for retaining 53BP1 at sites of damage. ..
  4. Zhang X, Zhao X, Fiskus W, Lin J, Lwin T, Rao R, et al. Coordinated silencing of MYC-mediated miR-29 by HDAC3 and EZH2 as a therapeutic target of histone modification in aggressive B-Cell lymphomas. Cancer Cell. 2012;22:506-523 pubmed publisher
    ..These findings define a MYC-mediated miRNA repression mechanism, shed light on MYC lymphomagenesis mechanisms, and reveal promising therapeutic targets for aggressive B-cell malignancies. ..
  5. Wang F, Liu M, Li X, Tang H. MiR-214 reduces cell survival and enhances cisplatin-induced cytotoxicity via down-regulation of Bcl2l2 in cervical cancer cells. FEBS Lett. 2013;587:488-95 pubmed publisher
    ..Taken together, these data suggest that miR-214 might be a candidate target for the development of novel therapeutic strategies to treat cervical cancer. ..
  6. Chu X, Qin X, Xu H, Li L, Wang Z, Li F, et al. Structural insights into Paf1 complex assembly and histone binding. Nucleic Acids Res. 2013;41:10619-29 pubmed publisher
    ..Our results shed light on the PAF1C assembly process and substrate recognition during various PAF1C-coordinated histone modifications. ..