Experts and Doctors on antiviral agents in Tianjin, Tianjin Shi, China

Summary

Locale: Tianjin, Tianjin Shi, China
Topic: antiviral agents

Top Publications

  1. Zeng D, Ma Y, Zhang R, Nie Q, Cui Z, Wang Y, et al. Synthesis and structure-activity relationship of α-keto amides as enterovirus 71 3C protease inhibitors. Bioorg Med Chem Lett. 2016;26:1762-6 pubmed publisher
    ..32±0.26μM, 1.88±0.35μM and 1.52±0.31μM, respectively) and favorable CC50 values (CC50>100μM). α-Keto amide may represent a good choice as a warhead for EV71 3C(pro) inhibitor. ..
  2. Wang C, Zhong Y, Zhang Y, Liu J, Wang Y, Jia W, et al. A network analysis of the Chinese medicine Lianhua-Qingwen formula to identify its main effective components. Mol Biosyst. 2016;12:606-13 pubmed publisher
    ..7 cell. In summary, we have developed a novel approach to identify the main effective components in a Chinese medicine LQF and experimentally validated some of the predictions. ..
  3. Guo Y, Wang Y, Cao L, Wang P, Qing J, Zheng Q, et al. A Conserved Inhibitory Mechanism of a Lycorine Derivative against Enterovirus and Hepatitis C Virus. Antimicrob Agents Chemother. 2016;60:913-24 pubmed publisher
    ..We also documented the significant synergistic anti-EV71 and anti-HCV effects of 1-acetyllycorine with reported inhibitors, supporting potential combination therapy for the treatment of EV71 and HCV infections. ..
  4. Wang S, Cheng X, Dong W, Wang R, Chou K. Three new powerful oseltamivir derivatives for inhibiting the neuraminidase of influenza virus. Biochem Biophys Res Commun. 2010;401:188-91 pubmed publisher
    ..Or at the very least, the findings may stimulate new strategy or provide useful insights for working on the target vitally important to the health of human beings. ..
  5. Huang Y, Liu Y, Liu Y, Song H, Wang Q. C ring may be dispensable for β-carboline: Design, synthesis, and bioactivities evaluation of tryptophan analog derivatives based on the biosynthesis of β-carboline alkaloids. Bioorg Med Chem. 2016;24:462-73 pubmed publisher
    ..We also found that these compounds showed antifungal activities and insecticidal activities. ..
  6. Li L, Li Z, Wang K, Liu Y, Li Y, Wang Q. Synthesis and antiviral, insecticidal, and fungicidal activities of gossypol derivatives containing alkylimine, oxime or hydrazine moiety. Bioorg Med Chem. 2016;24:474-83 pubmed publisher
    ..The fungicidal results revealed that all of compounds exhibited good activity against Physalospora piricola. ..
  7. Gu C, Li J, Li J, Chao F. Inhibition of hepatitis B virus by D-fraction from Grifola frondosa: synergistic effect of combination with interferon-alpha in HepG2 2.2.15. Antiviral Res. 2006;72:162-5 pubmed
    ..This 9-fold increase in antiviral activity of IFN suggested that GF-D could synergize with IFN. These results indicate that GF-D, in combination with IFN, might provide a potentially effective therapy against chronic HBV infections...
  8. Wang Z, Feng A, Cui M, Liu Y, Wang L, Wang Q. First discovery and stucture-activity relationship study of phenanthroquinolizidines as novel antiviral agents against tobacco mosaic virus (TMV). PLoS ONE. 2012;7:e52933 pubmed publisher
    ..Present study provides fundamental support for development and optimization of phenanthroquinolizidine alkaloids as potential inhibitors of plant virus...
  9. Yu W, Goddard C, Clearfield E, Mills C, Xiao T, Guo H, et al. Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion. J Med Chem. 2011;54:5660-70 pubmed publisher
    ..4 ± 0.4 ?M, SI ? 36. The lead candidates, both 1a (PBHBV-001) and 3c (PBHBV-2-15), were well-tolerated in both normal and HBV-transgenic mice and exhibited acceptable pharmacokinetics and bioavailability in Sprague-Dawley rats. ..

More Information

Publications18

  1. Zhang G, Li Y, Zheng S, Liu M, Li X, Tang H. Suppression of hepatitis B virus replication by microRNA-199a-3p and microRNA-210. Antiviral Res. 2010;88:169-75 pubmed publisher
    ..2.15 cells compared to HepG2 cells may play a role in regulating HBV replication and maintenance of a suitable level of virion production in persistent infection by targeting crucial HBV genes. ..
  2. Chang J, Wang Y, Shao L, Laberge R, Demaria M, Campisi J, et al. Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. Nat Med. 2016;22:78-83 pubmed publisher
    ..Thus, senolytic drugs may represent a new class of radiation mitigators and anti-aging agents. ..
  3. Feng B, Shang J, Wu S, Chen H, Han Y, Li Y, et al. [Efficacy and safety of pegylated interferon ?-2b injection (Y shape, 40 kD) in treatment of patients with genotype 1/6 chronic hepatitis C]. Zhonghua Gan Zang Bing Za Zhi. 2017;25:187-194 pubmed publisher
    ..9%?????????????????????????????93.8%?????????????????????96.30%?94.94%??????????????5.13%?5.06%? ??? peg-ifn???????????1/6?chc???????????peg-ifn?-2b?y??40 kd????????peg-ifn?-2a??????????. ..
  4. Yu X, Wei P, Wang Z, Liu Y, Wang L, Wang Q. Design, synthesis, antiviral activity and mode of action of phenanthrene-containing N-heterocyclic compounds inspired by the phenanthroindolizidine alkaloid antofine. Pest Manag Sci. 2016;72:371-8 pubmed publisher
    ..The present study lays a good foundation for us to find more efficient anti-plant virus reagents. ..
  5. Xing J, Han T, Liu L, Li Y, Li J, Li Y, et al. [Entecavir 1.0mg monotherapy or entecavir plus adefovir dipivoxil for patients with lamivudine-resistant chronic hepatitis B had suboptimal response to lamivudine plus adefovir dipivoxil]. Zhonghua Gan Zang Bing Za Zhi. 2011;19:828-32 pubmed publisher
    ..0 mg monotherapy, and it can achieve better virological and biochemical response. ..
  6. Yao X, Su Y, Liu C, Tan J, Liu L, Geng Y, et al. Establishment of an indicator cell line for monitoring bovine immunodeficiency virus infection and inhibitor susceptibility. J Virol Methods. 2010;163:25-30 pubmed publisher
    ..The BIV indicator cell line could also be used for the evaluation of the inhibitory effect of antiviral agents. The fusion inhibition effect of the heptad repeat 2 region of the BIV envelope protein could also be quantified...
  7. Xi Z, Zhang R, Yu Z, Ouyang D. The interaction between tylophorine B and TMV RNA. Bioorg Med Chem Lett. 2006;16:4300-4 pubmed
    ..This work may shed light on the possible molecular inhibition mechanism against TMV by tylophorine B, and provide clues in rational design of sequence-specific RNA binding antivirus drugs. ..
  8. Liu W, Wang H, Zhu B, Yin C, Chen S, Li J, et al. An activity-integrated strategy of the identification, screening and determination of potential neuraminidase inhibitors from Radix Scutellariae. PLoS ONE. 2017;12:e0175751 pubmed publisher
  9. Wang L, Bao B, Song G, Chen C, Zhang X, Lu W, et al. Discovery of unsymmetrical aromatic disulfides as novel inhibitors of SARS-CoV main protease: Chemical synthesis, biological evaluation, molecular docking and 3D-QSAR study. Eur J Med Chem. 2017;137:450-461 pubmed publisher
    ..The present research therefore has provided some meaningful guidance to design and identify anti-SARS drugs with totally new chemical structures. ..