Experts and Doctors on ppar gamma in Chengdu, Sichuan, China


Locale: Chengdu, Sichuan, China
Topic: ppar gamma

Top Publications

  1. Huang Y, Yang X, Wu Y, Jing W, Cai X, Tang W, et al. gamma-secretase inhibitor induces adipogenesis of adipose-derived stem cells by regulation of Notch and PPAR-gamma. Cell Prolif. 2010;43:147-56 pubmed publisher
    ..It may be due to depression of DLK-1/Pref-1 and promotion of de-PPAR-gamma activation, which work through inhibition of Notch-2-Hes-1 pathway by DAPT. ..
  2. Ba K, Yang X, Wu L, Wei X, Fu N, Fu Y, et al. Jagged-1-mediated activation of notch signalling induces adipogenesis of adipose-derived stem cells. Cell Prolif. 2012;45:538-44 pubmed publisher
    ..The results led to the conclusion that activation of Notch signalling had stimulated adipogenesis of mASCs in the presence of adipogenic medium by promoting expression of PPAR-?. ..
  3. Liao Z, Dong J, Wu W, Yang T, Wang T, Guo L, et al. Resolvin D1 attenuates inflammation in lipopolysaccharide-induced acute lung injury through a process involving the PPAR?/NF-?B pathway. Respir Res. 2012;13:110 pubmed publisher
    ..These results suggest that RvD1 may attenuate lung inflammation of LPS-induced acute lung injury by suppressing NF-?B activation through a mechanism partly dependent on PPAR? activation. ..
  4. Forootan F, Forootan S, Gou X, Yang J, Liu B, Chen D, et al. Fatty acid activated PPARγ promotes tumorigenicity of prostate cancer cells by up regulating VEGF via PPAR responsive elements of the promoter. Oncotarget. 2016;7:9322-39 pubmed publisher
  5. Kang X, Yang Z, Sheng J, Liu J, Xie Q, Zheng W, et al. Oleanolic acid prevents cartilage degeneration in diabetic mice via PPAR? associated mitochondrial stabilization. Biochem Biophys Res Commun. 2017;490:834-840 pubmed publisher
    ..And the reversed SOD2 expression and activity may be ascribed to decreased SOD2 protein degradation by OLA treatment, via PPPA?. In conclusion, OLA protected against the high-glucose-induced cartilage injury via PPAR?/SOD2 pathway. ..
  6. Gao Y, Xue J, Li X, Jia Y, Hu J. Metformin regulates osteoblast and adipocyte differentiation of rat mesenchymal stem cells. J Pharm Pharmacol. 2008;60:1695-700 pubmed publisher
    ..The reciprocal relationship between osteoblastic and adipogenic differentiation suggests that metformin may regulate osteoblastic and adipogenic differentiation through inhibition of PPARgamma. ..
  7. Yang L, Zhou J, Ma Q, Wang C, Chen K, Meng W, et al. Knockdown of PPAR ? gene promotes the growth of colon cancer and reduces the sensitivity to bevacizumab in nude mice model. PLoS ONE. 2013;8:e60715 pubmed publisher
    ..This study indicates that PPAR ? attenuates colon carcinogenesis. ..
  8. Wang X, Huang N, Yang M, Wei D, Tai H, Han X, et al. FTO is required for myogenesis by positively regulating mTOR-PGC-1α pathway-mediated mitochondria biogenesis. Cell Death Dis. 2017;8:e2702 pubmed publisher
    ..Summarily, our findings provide the first evidence for the contribution of FTO for skeletal muscle differentiation and a new insight to study the physiologic significance of RNA methylation. ..
  9. Li G, Ning C, Ma Y, Jin L, Tang Q, Li X, et al. miR-26b Promotes 3T3-L1 Adipocyte Differentiation Through Targeting PTEN. DNA Cell Biol. 2017;36:672-681 pubmed publisher
    ..Taken together, these results demonstrate that miR-26b might participate in regulating adipogenic differentiation in 3T3-L1 cells by inhibiting the PTEN expression, further highlighting the importance of miRNA in adipogenesis. ..

More Information


  1. Wu L, Cai X, Dong H, Jing W, Huang Y, Yang X, et al. Serum regulates adipogenesis of mesenchymal stem cells via MEK/ERK-dependent PPARgamma expression and phosphorylation. J Cell Mol Med. 2010;14:922-32 pubmed publisher
    ..These data suggested that activation of the MEK/ERK signalling pathway by high serum concentration promoted PPARgamma expression and phosphorylation, and subsequently enhanced adipogenic differentiation of MSCs. ..
  2. Chen X, Bing Z, He J, Jiang L, Luo X, Su Y, et al. Downregulation of peroxisome proliferator-activated receptor-gamma expression in hypertensive atrial fibrillation. Clin Cardiol. 2009;32:337-45 pubmed publisher
    ..01). In hypertensive patients, increased inflammatory cytokines were associated with increased incidence of AF and atrial remodeling; PPARgamma may be involved in the pathogenesis of AF by regulation of inflammation. ..