Experts and Doctors on enzyme inhibitors in Chengdu, Sichuan, China


Locale: Chengdu, Sichuan, China
Topic: enzyme inhibitors

Top Publications

  1. Hou W, Li Y, Zhang Q, Wei X, Peng A, Chen L, et al. Triterpene acids isolated from Lagerstroemia speciosa leaves as alpha-glucosidase inhibitors. Phytother Res. 2009;23:614-8 pubmed publisher
    ..The kinetics of inhibition of corosolic acid was also discussed. Results from this study might provide the scientific evidence for LSL for the treatment of diabetes in traditional medicine...
  2. Xian H, Wang F, Teng W, Yang D, Zhang M. Thyroid hormone induce a p53-dependent DNA damage through PI3K/Akt activation in sperm. Gene. 2017;615:1-7 pubmed publisher
    ..Our results highlight that inhibition of PI3K/Akt pathway or p53 degradation is important in maintaining sperm motility in a thyroxine receptor (TR)-dependent manner. ..
  3. Zheng B, Zhou R, Gong Y, Yang X, Shan Q. Proteasome inhibitor bortezomib overcomes P-gp-mediated multidrug resistance in resistant leukemic cell lines. Int J Lab Hematol. 2012;34:237-47 pubmed publisher
  4. Jin H, Zhou J, Pu T, Zhang A, Gao X, Tao K, et al. Synthesis of novel fenfuram-diarylether hybrids as potent succinate dehydrogenase inhibitors. Bioorg Chem. 2017;73:76-82 pubmed publisher
    ..Furthermore, it was shown that the 2-chlorophenyl group of compound 1c formed a ?-? stacking with D/Tyr-128 and a Cl-? interaction with B/His-249, which made compound 1c more active than fenfuram against SDH. ..
  5. Zhao L, Yu C, Zhou S, Lau W, Lau B, Luo Z, et al. Epigenetic repression of PDZ-LIM domain-containing protein 2 promotes ovarian cancer via NOS2-derived nitric oxide signaling. Oncotarget. 2016;7:1408-20 pubmed publisher
    ..These results suggest that PDLIM2 might be involved in ovarian cancer pathogenesis, which could serve as a promising therapeutic target for ovarian cancer patients. ..
  6. Su Y, Xie W, Wang C, Peng L, Zhou X, Ye L. JNK/P38 mitogen-activated protein kinase used for hepatocyte growth factor-induced proliferation, differentiation, and migration in human dental papilla cells. J Endod. 2012;38:1207-13 pubmed publisher
    ..This study investigated the signaling pathway used by HGF in human dental papilla cells (hDPCs) to identify the role of mitogen-activated protein kinase (MAPK) pathways in inducing cell proliferation, differentiation, and migration...
  7. Huang Y, Zhao Y, Gao X, Zhao Z, Jing Z, Zeng W, et al. Intestinal alpha-glucosidase inhibitory activity and toxicological evaluation of Nymphaea stellata flowers extract. J Ethnopharmacol. 2010;131:306-12 pubmed publisher
    ..In addition, NSF extract was studied to assess its possible acute oral toxicity and genotoxicity...
  8. Huang Y, Yang X, Wu Y, Jing W, Cai X, Tang W, et al. gamma-secretase inhibitor induces adipogenesis of adipose-derived stem cells by regulation of Notch and PPAR-gamma. Cell Prolif. 2010;43:147-56 pubmed publisher
    ..It may be due to depression of DLK-1/Pref-1 and promotion of de-PPAR-gamma activation, which work through inhibition of Notch-2-Hes-1 pathway by DAPT. ..
  9. Li D, Qu Y, Mao M, Zhang X, Li J, Ferriero D, et al. Involvement of the PTEN-AKT-FOXO3a pathway in neuronal apoptosis in developing rat brain after hypoxia-ischemia. J Cereb Blood Flow Metab. 2009;29:1903-13 pubmed publisher
    ..Our findings suggest that the PTEN-Akt-FOXO3a pathway is involved in neuronal apoptosis in neonatal rat brain after HI. Agents targeting PTEN may offer a promise to rescue neurons from HI brain damage. ..

More Information


  1. He H, Wang X, Zheng X, Sun H, Shi X, Zhong Y, et al. Concurrent blockade of the NF-kappaB and Akt pathways potently sensitizes cancer cells to chemotherapeutic-induced cytotoxicity. Cancer Lett. 2010;295:38-43 pubmed publisher
    ..These data suggest that NF-kappaB and Akt cooperatively attenuate therapeutic-induced cytotoxicity and concurrently blocking these pathways is an effective strategy for improving the anticancer efficacy of therapeutics. ..
  2. Tang Y, Sun F, Li X, Zhou Y, Yin S, Zhou X. Porphyromonas endodontalis lipopolysaccharides induce RANKL by mouse osteoblast in a way different from that of Escherichia coli lipopolysaccharide. J Endod. 2011;37:1653-8 pubmed publisher
    ..The receptor activator of nuclear factor-?B ligand (RANKL) has been proven to be the key regulator of bone remodeling. This study investigated P. endodontalis LPS-induced RANKL production and LPS signaling in mouse osteoblasts...
  3. Peng H, Lv H, Wang Y, Liu Y, Li C, Meng L, et al. Clematis montana lectin, a novel mannose-binding lectin from traditional Chinese medicine with antiviral and apoptosis-inducing activities. Peptides. 2009;30:1805-15 pubmed publisher
  4. Lu W, Cheng F, Yan W, Li X, Yao X, Song W, et al. Selective targeting p53WT lung cancer cells harboring homozygous p53 Arg72 by an inhibitor of CypA. Oncogene. 2017;36:4719-4731 pubmed publisher
    ..Collectively, this study demonstrates that pharmacologic inhibition of CypA offers a potential therapeutic strategy via specific activation of p53-72R in NSCLC. ..
  5. Sun X, Zhou H, Luo X, Li S, Yu D, Hua J, et al. Neuroprotection of brain-derived neurotrophic factor against hypoxic injury in vitro requires activation of extracellular signal-regulated kinase and phosphatidylinositol 3-kinase. Int J Dev Neurosci. 2008;26:363-70 pubmed publisher
  6. Li F, Zhou Y, Cheng N, Mao H, Jiang L, Li N, et al. Epidermal growth factor receptor as a target for anti-proliferative treatment of proliferative cholangitis in hepatolithiasis. J Surg Res. 2011;166:87-94 pubmed publisher
    ..Thus, the aim of this study was to determine whether epidermal growth factor receptor inhibitor (AG-1478) could inhibit hyperplasia and lithogenic potentiality of PC...
  7. Cheng R, Cheng L, Shao M, Yang H, Wang F, Hu T, et al. Roles of lysophosphatidic acid and the Rho-associated kinase pathway in the migration of dental pulp cells. Exp Cell Res. 2010;316:1019-27 pubmed publisher
    ..LPA and ROCK inhibition induced activation of another Rho GTPase, Rac, which may explain how LPA and ROCK inhibition increases cellmigration and lamellipodium formation. ..
  8. Zhang J, Zhou B, Liu Y, Chen K, Bao P, Wang Y, et al. Wnt inhibitory factor-1 functions as a tumor suppressor through modulating Wnt/?-catenin signaling in neuroblastoma. Cancer Lett. 2014;348:12-9 pubmed publisher
    ..These results provide support that WIF-1 is downregulated and functions as a tumor suppressor by antagonizing Wnt/?-catenin signaling in neuroblastoma, suggesting a potential role as a therapeutic target in neuroblastoma. ..
  9. Chen L, Wang T, Wang X, Sun B, Li J, Liu D, et al. Blockade of advanced glycation end product formation attenuates bleomycin-induced pulmonary fibrosis in rats. Respir Res. 2009;10:55 pubmed publisher