Experts and Doctors on apoptosis in Chengdu, Sichuan, China


Locale: Chengdu, Sichuan, China
Topic: apoptosis

Top Publications

  1. Yuan Z, Chen L, Fan L, Tang M, Yang G, Yang H, et al. Liposomal quercetin efficiently suppresses growth of solid tumors in murine models. Clin Cancer Res. 2006;12:3193-9 pubmed
    ..Our data indicated that pegylated liposomal quercetin can significantly improve the solubility and bioavailability of quercetin and can be a potential application in the treatment of tumor. ..
  2. Li J, Qu Y, Chen D, Zhang L, Zhao F, Luo L, et al. The neuroprotective role and mechanisms of TERT in neurons with oxygen-glucose deprivation. Neuroscience. 2013;252:346-58 pubmed publisher
    ..The underlying mechanisms may be associated with regulating Bcl-2/Bax expression ratio, attenuating ROS generation, and increasing mitochondrial membrane potential. ..
  3. Liu B, Peng H, Yao Q, Li J, Van Damme E, Balzarini J, et al. Bioinformatics analyses of the mannose-binding lectins from Polygonatum cyrtonema, Ophiopogon japonicus and Liparis noversa with antiproliferative and apoptosis-inducing activities. Phytomedicine. 2009;16:601-8 pubmed publisher
    ..Furthermore, our results demonstrate that these lectins induce apoptosis in MCF-7 cells via a caspase-dependent pathway...
  4. Yan F, Ruan X, Yang H, Yao S, Zhao X, Gou L, et al. Identification, characterization, and effects of Xenopus laevis PNAS-4 gene on embryonic development. J Biomed Biotechnol. 2010;2010:134764 pubmed publisher
    ..In addition, embryos microinjected with xPNAS-4 antisense morpholino oligonucleotides (MOs) exhibited a failure of head development and shortened axis...
  5. Yuan H, Niu L, Jiao K, Pei D, Pramanik C, Li J, et al. Revival of nitrogen-containing bisphosphonate-induced inhibition of osteoclastogenesis and osteoclast function by water-soluble microfibrous borate glass. Acta Biomater. 2016;31:312-325 pubmed publisher
    ..This ionic cocktail may have the potential to be further developed into a new adjunctive treatment for BRONJ. ..
  6. Xu M, Suo Y, Gong J, Zhang M, Yan L. Prolongation of liver allograft survival by dendritic cells modified with NF-kappaB decoy oligodeoxynucleotides. World J Gastroenterol. 2004;10:2361-8 pubmed
  7. Peng H, Lv H, Wang Y, Liu Y, Li C, Meng L, et al. Clematis montana lectin, a novel mannose-binding lectin from traditional Chinese medicine with antiviral and apoptosis-inducing activities. Peptides. 2009;30:1805-15 pubmed publisher
  8. Yu X, Ling W, Mi M. Relationship of impairment induced by intracellular S-adenosylhomocysteine accumulation with DNA methylation in human umbilical vein endothelial cells treated with 3-deazaadenosine. Int J Exp Pathol. 2009;90:638-48 pubmed publisher
    ..These findings suggest that SAH can act as the potential molecular biological marker in the promotion of atherogenesis. ..
  9. Li T, Zhang P, Liu J, Zhou R, Li Q, You Z, et al. Protective effects of hemoglobin-based oxygen carrier given to isolated heart during ischemia via attenuation of mitochondrial oxidative damage. Free Radic Biol Med. 2010;48:1079-89 pubmed publisher
    ..In conclusion, our results demonstrate the cardioprotective effect of HBOC on I/R heart and reveal that this protection was mediated in large part by attenuation of mitochondrial oxidative damage...

More Information

Publications266 found, 100 shown here

  1. Gong G, Qin Y, Huang W, Zhou S, Wu X, Yang X, et al. Protective effects of diosgenin in the hyperlipidemic rat model and in human vascular endothelial cells against hydrogen peroxide-induced apoptosis. Chem Biol Interact. 2010;184:366-75 pubmed publisher
  2. Huang R, Chen X, Huang Y, Chen N, Zeng H. The multikinase inhibitor sorafenib induces caspase-dependent apoptosis in PC-3 prostate cancer cells. Asian J Androl. 2010;12:527-34 pubmed publisher
    ..In conclusion, sorafenib induces apoptosis through a caspase-dependent mechanism with down-regulated anti-apoptotic proteins in androgen-independent prostate cancer cells in vitro. ..
  3. Lu Y, Jin X, Chen Y, Li S, Yuan Y, Mai G, et al. Mesenchymal stem cells protect islets from hypoxia/reoxygenation-induced injury. Cell Biochem Funct. 2010;28:637-43 pubmed publisher
    ..This study provides an experimental basis for therapeutic strategies based on enhancing islet function. ..
  4. Luo D, Yang G, Liu J, Yang Y, Dong Q. Effects of varicocele on testosterone, apoptosis and expression of StAR mRNA in rat Leydig cells. Asian J Androl. 2011;13:287-91 pubmed publisher
    ..01). Our data show that varicocele did impair Leydig cell function by increasing apoptosis and suppressing the expression of the StAR protein...
  5. Gou L, Wang W, Tong A, Yao Y, Zhou Y, Yi C, et al. Proteomic identification of RhoA as a potential biomarker for proliferation and metastasis in hepatocellular carcinoma. J Mol Med (Berl). 2011;89:817-27 pubmed publisher
    ..Our data suggest that RhoA may serve as a potential biomarker and an attractive therapeutic target for HCC. ..
  6. Yuan Z, Wang F, Zhao Z, Zhao X, Qiu J, Nie C, et al. BIM-mediated AKT phosphorylation is a key modulator of arsenic trioxide-induced apoptosis in cisplatin-sensitive and -resistant ovarian cancer cells. PLoS ONE. 2011;6:e20586 pubmed publisher
  7. Guo N, Peng Z. MG132, a proteasome inhibitor, induces apoptosis in tumor cells. Asia Pac J Clin Oncol. 2013;9:6-11 pubmed publisher
    ..In this article we review the mechanism of the induction of apoptosis in order to provide information required for research. ..
  8. Yang Y, Tong Y, Gong M, Lu Y, Wang C, Zhou M, et al. Activation of PPARβ/δ protects pancreatic β cells from palmitate-induced apoptosis by upregulating the expression of GLP-1 receptor. Cell Signal. 2014;26:268-78 pubmed publisher
    ..Our study suggested that the anti-apoptotic action of GW may involve its transcriptional regulation of GLP-1R, and PPARβ/δ activation may represent a new therapeutic method for protecting pancreatic β cells from lipotoxicity. ..
  9. Wang X, Wang X, Chen H, Wu D, Chen J, Wang X, et al. Ghrelin inhibits doxorubicin cardiotoxicity by inhibiting excessive autophagy through AMPK and p38-MAPK. Biochem Pharmacol. 2014;88:334-50 pubmed publisher
  10. Yan J, Wang Q, Zheng X, Sun H, Zhou Y, Li D, et al. Luteolin enhances TNF-related apoptosis-inducing ligand's anticancer activity in a lung cancer xenograft mouse model. Biochem Biophys Res Commun. 2012;417:842-6 pubmed publisher
    ..Data from this study thus provide strong in vivo evidence supporting that luteolin is a potential sensitizer for TRAIL in anticancer therapy. ..
  11. Li Y, Hu Z, Chen B, Bu Q, Lu W, Deng Y, et al. Taurine attenuates methamphetamine-induced autophagy and apoptosis in PC12 cells through mTOR signaling pathway. Toxicol Lett. 2012;215:1-7 pubmed publisher
    ..Collectively, our study shows that taurine protects METH-induced PC12 cells damage by attenuating ROS production, apoptosis and autophagy, at least in part, via mTOR signaling pathway...
  12. Liu G, Wang C, Ding Z. Overexpression of the truncated form of Livin reveals a complex interaction with caspase-3. Int J Oncol. 2013;42:2037-45 pubmed publisher
    ..This second cleavage was possibly related to activated caspase-3. The resulted C-terminal fragment (livC) was an anti-apoptotic factor. Our study may help to deepen our understanding of the role of Livin in the regulation of cell death. ..
  13. Peng C, Ma J, Gao X, Tian P, Li W, Zhang L. High glucose induced oxidative stress and apoptosis in cardiac microvascular endothelial cells are regulated by FoxO3a. PLoS ONE. 2013;8:e79739 pubmed publisher
    ..Our data provide evidence that high glucose induced FoxO3a activation which suppressed ROS accumulation, and in parallel, resulted in apoptosis of CMECs. ..
  14. Zhao Y, Bu Q, Zhou Y, Lv L, Yan G, Chen B, et al. Mechanism study of Aconitum-induced neurotoxicity in PC12 cells: involvement of dopamine release and oxidative damage. Neurotoxicology. 2010;31:752-7 pubmed publisher
    ..In conclusion, our results indicate that Aconitum can evoke dopamine release from dopaminergic neurons; excessive extracellular of dopamine can then create stresses on cellular antioxidant systems and induce neuron apoptosis...
  15. He Y, Huang J, Wang P, Shen X, Li S, Yang L, et al. Emodin potentiates the antiproliferative effect of interferon α/β by activation of JAK/STAT pathway signaling through inhibition of the 26S proteasome. Oncotarget. 2016;7:4664-79 pubmed publisher
    ..Therefore, emodin warrants further investigation as a new means to enhance the efficacy of IFN-α/β. ..
  16. Ye T, Zhu S, Zhu Y, Feng Q, He B, Xiong Y, et al. Cryptotanshinone induces melanoma cancer cells apoptosis via ROS-mitochondrial apoptotic pathway and impairs cell migration and invasion. Biomed Pharmacother. 2016;82:319-26 pubmed publisher
  17. Li Y, Li M, Wang L, Jiang Z, Li W, Li H. [Induction of apoptosis of cultured hepatocarcinoma cell by essential oil of Artemisia Annul L]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2004;35:337-9 pubmed
    ..The sub-G1 peak was exhibited by FCM, and the DNA ladder pattern was observed. These findings demonstrated that the essential oil of Artemisia annul L. could induce apoptosis of cultured SMMC-7721. ..
  18. Zeng L, Peng Z. [Growth inhibitory effects of THY1 gene on epithelial ovarian cancer SKOV3 cells]. Nan Fang Yi Ke Da Xue Xue Bao. 2007;27:84-7, 91 pubmed
    ..1(+)-THY1 can be expressed stably in human ovarian cancer cell line SKOV3. THY1 transfection can inhibit the growth of SKOV3 cells in vitro, suggesting the important role of THY1 gene in pathogenesis and development of ovarian cancer. ..
  19. Li T, Li J, Liu J, Zhang P, Wu W, Zhou R, et al. Polymerized placenta hemoglobin attenuates ischemia/reperfusion injury and restores the nitroso-redox balance in isolated rat heart. Free Radic Biol Med. 2009;46:397-405 pubmed publisher
    ..In conclusion, our results demonstrate that HBOCs protected isolated heart from I/R injury and this protection was associated with attenuation of NO-mediated myocardial apoptosis and restoration of the nitroso-redox balance. ..
  20. Chen X, Hu X, Wu S, Zhang Y, Xiao B, Shang H. RNA interference-mediated inhibition of wild-type Torsin A expression increases apoptosis caused by oxidative stress in cultured cells. Neurochem Res. 2010;35:1214-23 pubmed publisher
  21. He W, Meng T, Wu M, Shi B, Lu S, Li C. Perturbation of Fgf10 signal pathway in mouse embryonic palate by dexamethasone and vitamin B12 in vivo. J Pediatr Surg. 2010;45:2030-5 pubmed publisher
    ..The objective of this study was to assess whether dexamethasone and vitamin B(12) affected the Fgf10 signal pathway of mouse embryonic palate...
  22. Chen T, Guo Z, Li M, Li J, Jiao X, Zhang Y, et al. Tumour necrosis factor-like weak inducer of apoptosis (TWEAK), an important mediator of endothelial inflammation, is associated with the pathogenesis of Henoch-Schonlein purpura. Clin Exp Immunol. 2011;166:64-71 pubmed publisher
    ..TWEAK may act as a regulator of nuclear factor-?B (NF-?B) activation and chemokine production in human dermal microvascular endothelial cells, thus promoting leucocyte migration in cutaneous vasculitis. ..
  23. Wu B, Bao L, Sun Z, Li D, Zhang Y. [The OmpA-like protein Loa22 from Leptospira interrogans serovar lai induces apoptosis in A549 via Ca2+ signal pathway]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2011;42:298-302 pubmed
    ..To study the effect of Loa22 mature peptide on the apoptosis of A549 to explore the mechanism of pulmonary impairment in severe forms of leptospirosis...
  24. Jiang Z, Chai J, Chuang H, Li S, Wang T, Cheng Y, et al. Artesunate induces G0/G1 cell cycle arrest and iron-mediated mitochondrial apoptosis in A431 human epidermoid carcinoma cells. Anticancer Drugs. 2012;23:606-13 pubmed publisher
  25. Xue H, Huang X, He D, Lin S, Wang S, Niu T. [Effects of Marsdenia tenacissima extract on proliferation and apoptosis of hematologic neoplasm cell line cells]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2012;43:174-9 pubmed
  26. Gao X, Wang B, Wei X, Men K, Zheng F, Zhou Y, et al. Anticancer effect and mechanism of polymer micelle-encapsulated quercetin on ovarian cancer. Nanoscale. 2012;4:7021-30 pubmed publisher
    ..Our data suggested that QU/MPEG-PCL micelles were a novel nano-formulation of quercetin with a potential clinical application in ovarian cancer therapy. ..
  27. Liu H, Zhu Y, Zhang T, Zhao Z, Zhao Y, Cheng P, et al. Anti-tumor effects of atractylenolide I isolated from Atractylodes macrocephala in human lung carcinoma cell lines. Molecules. 2013;18:13357-68 pubmed publisher
  28. Xie G, Xie Y, Hu Y, Zhu Z. Cytotoxic sesquiterpenoids from Ligularia pleurocaulis. Phytochemistry. 2016;125:99-105 pubmed publisher
    ..2, 5.6 and 8.4 μM against MCF-7, HepG2 and A549, respectively. ..
  29. Shi W, Deng J, Tong R, Yang Y, He X, Lv J, et al. Molecular mechanisms underlying mangiferin-induced apoptosis and cell cycle arrest in A549 human lung carcinoma cells. Mol Med Rep. 2016;13:3423-32 pubmed publisher
    ..The present study clarified the molecular mechanisms underlying mangiferin-induced antitumor activities, and suggested that mangiferin may be considered a potential antineoplastic drug for the future treatment of cancer. ..
  30. Wang H, Mu D. [17??estradiol suppresses hyperoxia?induced apoptosis of oligodendrocyte precursor cells through paired?immunoglobulin?like receptor B]. Zhongguo Dang Dai Er Ke Za Zhi. 2016;18:650-5 pubmed
    ..E2 treatment markedly down-regulated the expression of PirB. E2 treatment or PirB silencing markedly decreased hyperoxia-induced apoptosis and increased cell viability in OPCs. E2 can protect OPCs from hyperoxia-induced apoptosis. ..
  31. Liu Y, Chen X, Yu J, Chi J, Long F, Yang H, et al. Deletion Of XIAP reduces the severity of acute pancreatitis via regulation of cell death and nuclear factor-κB activity. Cell Death Dis. 2017;8:e2685 pubmed publisher
    ..The critical role of XIAP in cell death and inflammation suggests that inhibition of XIAP represents a potential therapeutic strategy for the treatment of acute pancreatitis. ..
  32. Hu J, Chen L, Liu L, Chen X, Chen P, Yang G, et al. Liposomal honokiol, a potent anti-angiogenesis agent, in combination with radiotherapy produces a synergistic antitumor efficacy without increasing toxicity. Exp Mol Med. 2008;40:617-28 pubmed
    ..Liposomal honokiol can enhance tumor cell radiosensitivity in vitro and in vivo, indicating that radiotherapy combined with liposomal honokiol can lead to greater anti-tumor efficacy. ..
  33. Liu L, Deng H, Wang Y, Chen P, Yang Y, Yang H, et al. A novel strategy for tumour therapy combining cell apoptosis and active immunity induced by caspy2, a zebrafish caspase. J Cell Mol Med. 2009;13:2271-81 pubmed publisher
    ..In this study, we developed a novel anticancer strategy that combines both induction of apoptosis and immune response in mice-bearing tumours with a single caspy2 gene. This approach may provide an important way for treatment of cancer. ..
  34. Wang J, Yin Y, Hua H, Li M, Luo T, Xu L, et al. Blockade of GRP78 sensitizes breast cancer cells to microtubules-interfering agents that induce the unfolded protein response. J Cell Mol Med. 2009;13:3888-97 pubmed publisher
    ..Combination of compounds capable of suppressing GRP78 might be a novel approach for improving the effectiveness of microtubules-targeted chemotherapy. ..
  35. Li J, Liu X, Ran X, Chen J, Li X, Wu W, et al. Sterol regulatory element-binding protein-1c knockdown protected INS-1E cells from lipotoxicity. Diabetes Obes Metab. 2010;12:35-46 pubmed publisher
    ..SREBP-1c might be a major factor responsible for beta-cell lipotoxicity, and SREBP-1c knockdown could protect INS-1E cells from lipotoxicity, which is implicating a therapeutic potential for treating diabetes related to lipotoxicity. ..
  36. Sun W, Chen J, Wang Y, Zheng H. Autophagy protects breast cancer cells from epirubicin-induced apoptosis and facilitates epirubicin-resistance development. Autophagy. 2011;7:1035-44 pubmed
    ..Also, this finding indicates that the use of clinically applicable autophagy inhibitors might be one of the important strategies for breast cancer therapy. ..
  37. Fu L, Zhou C, Yao S, Yu J, Liu B, Bao J. Plant lectins: targeting programmed cell death pathways as antitumor agents. Int J Biochem Cell Biol. 2011;43:1442-9 pubmed publisher
    ..And, this research may, in turn, ultimately help cancer biologists and clinicians to exploit lectins as potential novel antitumor drugs in the future...
  38. Li D, Qu Y, Li J, Zhang L, Xiong T, Mu D. [Role of the FOXO3a transcription factor in neuronal apoptosis in neonatal rats with hypoxic-ischemic brain damage]. Zhongguo Dang Dai Er Ke Za Zhi. 2013;15:1023-7 pubmed
    ..HI induces FOXO3a translocation from cytoplasm to nucleus, and enhances protein expression of its target gene Bim in the neonatal rat brain. The upregulation of Bim expression might be related to neuronal apoptosis. ..
  39. Guan S, Li L, Zhu X, Yang Y, Zhang Z, Huang Y. An in vitro investigation of a detachable fork-like structure as efficient nuclear-targeted sub-unit in A2780 cell cultures. Int J Pharm. 2016;500:100-9 pubmed publisher
  40. Li H, Jiang W, Liu Y, Jiang J, Zhang Y, Wu P, et al. The metabolites of glutamine prevent hydroxyl radical-induced apoptosis through inhibiting mitochondria and calcium ion involved pathways in fish erythrocytes. Free Radic Biol Med. 2016;92:126-140 pubmed publisher
  41. Zou Y, Zhang J, Wang J, Peng L, Li G, Wang L. Erythropoietin Receptor Activation Protects the Kidney From Ischemia/Reperfusion-Induced Apoptosis by Activating ERK/p53 Signal Pathway. Transplant Proc. 2016;48:217-21 pubmed publisher
    ..These findings demonstrated that EPO pretreatment can attenuate renal IR injury by inhibiting apoptosis by promoting activation of the ERK/p53 signaling. ..
  42. Cao D, Wang X, Lei L, Ma L, Wang F, Wang C, et al. Synthesis, in vitro and in vivo evaluation of novel substituted N-(4-(2-(4-benzylpiperazin-1-yl)ethoxy)phenyl)-N-methyl-quinazolin-4-amines as potent antitumor agents. Bioorg Med Chem Lett. 2016;26:1931-5 pubmed publisher
    ..Importantly, 7a significantly inhibited tumor growths in HepG2 xenograft models without causing significant loss of body weight, suggesting that 7a is a promising new anticancer agent to be developed. ..
  43. Lan T, Zhao H, Xiang B, Wang J, Liu Y. Suture compression induced midpalatal suture chondrocyte apoptosis with increased caspase-3, caspase-9, Bad, Bak, Bax and Bid expression. Biochem Biophys Res Commun. 2017;489:179-186 pubmed publisher
    ..No expression of Bcl-2 and Bcl-xl was detected. Continuous compression force induces chondrocytes apoptosis in the mid-palatal suture. This process might be associated with the mitochondrial pathway. ..
  44. Yang W, Li G, Zhou Q, Liu W, Chen N, Gong J. [The frequency of API2-MALT1 fusion gene variants in MALT lymphoma and its correlation with apoptosis of MALT lymphoma]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005;22:35-9 pubmed
    ..A1446-M1123 was noted to be probably the main type of API2-MALT1 variant in MALT lymphoma of Chinese. API2-MALT1 transcript was confirmed to be associated with the levels of apoptosis and API2 of MALT lymphoma. ..
  45. Gou L, Tong A, Yan F, Yuan Z, He F, Wang W, et al. Altered protein-expressing profile in hPNAS4-induced apoptosis in A549 human lung adenocarcinoma cells. J Cell Biochem. 2009;108:1211-9 pubmed publisher
    ..Our data provide molecular evidence and possible associated pathway in hPNAS4-induced apoptosis through proteomic strategy, which should be contributed to further investigation on biological function of hPNAS4. ..
  46. Xie Y, Chen S, Wang C, Tang C. SOM230 combined with celecoxib prolongs the survival in nude mice with HepG-2 xenografts. Cancer Biol Ther. 2011;12:86-92 pubmed publisher
    ..This impressive strategy appears promising as a systemic therapy for patients with hepatocellular carcinoma (HCC). ..
  47. Liu P, Gou M, Yi T, Qi X, Xie C, Zhou S, et al. The enhanced antitumor effects of biodegradable cationic heparin-polyethyleneimine nanogels delivering HSulf-1 gene combined with cisplatin on ovarian cancer. Int J Oncol. 2012;41:1504-12 pubmed publisher
    ..Collectively, these observations provide evidence that HPEI nanogels delivering HSulf-1 combined with DDP may have a promising application in the therapy of human ovarian cancer. ..
  48. Chen C, Jiang X, Hu Y, Zhang Z. The protective role of resveratrol in the sodium arsenite-induced oxidative damage via modulation of intracellular GSH homeostasis. Biol Trace Elem Res. 2013;155:119-31 pubmed publisher
  49. Cheng L, Tian F, Tang L, Chen G, Luo Z, Ren J, et al. Repression of Farnesoid X receptor contributes to biliary injuries of liver grafts through disturbing cholangiocyte bile acid transport. Am J Transplant. 2013;13:3094-102 pubmed publisher
    ..These findings indicated that FXR repression under ischemic/hypoxic conditions contributed to biliary epithelial damages by disturbing BA transporting of cholangiocytes after LT. ..
  50. Feng J, Xue S, Pang Q, Rang Z, Cui F. miR-141-3p inhibits fibroblast proliferation and migration by targeting GAB1 in keloids. Biochem Biophys Res Commun. 2017;490:302-308 pubmed publisher
    ..All data suggested that miR-141-3p decreased the proliferation and migration of keloid fibroblasts by repressing GAB1 expression, providing a useful target for keloid management. ..
  51. Yin W, Chen N, Zhang Y, Zeng H, Chen X, He Y, et al. Survivin nuclear labeling index: a superior biomarker in superficial urothelial carcinoma of human urinary bladder. Mod Pathol. 2006;19:1487-97 pubmed
    ..6-26.7, P=0.0080) as well as progression-free survival (RR=4.4, 95% confidence interval=1.3-14.6, P=0.0151). We conclude that BIRC5-N is a superior biologic and prognostic marker for Ta/T1 urothelial carcinomas of urinary bladder. ..
  52. Ling B, Liang S, Xu Y, Zhao X, Tang M, Liu X, et al. Differential proteomic analysis of HeLa cells treated with Honokiol using a quantitative proteomic strategy. Amino Acids. 2008;35:115-22 pubmed
    ..The changed proteins were classified into 9 different categories, which covered a broad variety of cellular functions. In conclusion, HNK performs cytotoxicity to HeLa cells through co-operating of many proteins and different pathways. ..
  53. Liu Z, Liu B, Zhang Z, Zhou T, Bian H, Min M, et al. A mannose-binding lectin from Sophora flavescens induces apoptosis in HeLa cells. Phytomedicine. 2008;15:867-75 pubmed publisher
    ..Also, bioinformatics analyses showed that this lectin is speculated to bind a certain mannose-containing receptor on cancer cell surface thereby initiating downstream caspase cascade...
  54. Wang Y, Tang X, Zhou Q, Che G, Chen X, Zhu D. [An experimental study on targeting suicide gene therapy for lung cancer with HSV-TK driven by hTERT promoter]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2008;39:701-5 pubmed
    ..7%, 14.3%, 7.0% and 8.0% respectively). TK gene driven by hTERT promoter could express selectively in lung cancer cell. Lung cancer cell could be specifically inhibited by HSV-TK/GCV driven by hTERT promoter in vitro and in vivo. ..
  55. Yang L, Zheng X, Sun H, Zhong Y, Wang Q, He H, et al. Catalase suppression-mediated H(2)O(2) accumulation in cancer cells by wogonin effectively blocks tumor necrosis factor-induced NF-?B activation and sensitizes apoptosis. Cancer Sci. 2011;102:870-6 pubmed publisher
    ..Our data provide important insights into the molecular mechanism underlying wogonin's anticancer activity, and suggest this common flavonoid could be used as a TNF adjuvant for cancer therapy. ..
  56. Liu D, Huang Y, Zeng J, Chen B, Huang N, Guo N, et al. Down-regulation of JAK1 by RNA interference inhibits growth of the lung cancer cell line A549 and interferes with the PI3K/mTOR pathway. J Cancer Res Clin Oncol. 2011;137:1629-40 pubmed publisher
    ..The knockdown of JAK1 significantly inhibits tumourigenicity of the A549 cell line and demonstrates that crosstalk between the JAK1 and PI3K/mTOR pathways is involved. ..
  57. Xia L, Luo Q, Lin H, Zhang J, Guo H, He C. The effect of different treatment time of millimeter wave on chondrocyte apoptosis, caspase-3, caspase-8, and MMP-13 expression in rabbit surgically induced model of knee osteoarthritis. Rheumatol Int. 2012;32:2847-56 pubmed publisher
    ..But only a decreasing trend of caspase-8 expression was found. ..
  58. Huang N, Zhu J, Liu D, Li Y, Chen B, He Y, et al. Overexpression of Bcl-2-associated death inhibits A549 cell growth in vitro and in vivo. Cancer Biother Radiopharm. 2012;27:164-8 pubmed publisher
    ..Taken together, our results indicate that overexpression of BAD inhibits the growth of A549 cells in vitro and in vivo, through inhibiting cell proliferation and inducing apoptosis. Thus, BAD could be a potential therapeutic target. ..
  59. Zhang C, Liu L, Yu Y, Chen B, Tang C, Li X. Antitumor effects of ginsenoside Rg3 on human hepatocellular carcinoma cells. Mol Med Rep. 2012;5:1295-8 pubmed publisher
  60. He H, Fan P, Yin T, Chen Q, Shi H, Liu S, et al. Local delivery of recombinant adenovirus expressing hepatitis B virus X protein and interleukin-12 results in antitumor effects via inhibition of hepatoma cell growth and intervention of tumor microenvironment. Int J Mol Med. 2012;30:599-605 pubmed publisher
  61. Qiu S, Du Y, Wang L, Hu C. Chromaffin cells of the adrenal gland in the beagle dog. Anat Histol Embryol. 2013;42:144-50 pubmed publisher
    ..Terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL) assay for detecting the apoptotic signalling identified the apoptosis of the chromaffin cells in the capsule. ..
  62. Zhou R, Huang W, Ma C, Zhou Y, Yao Y, Wang Y, et al. HOCl oxidation-modified CT26 cell vaccine inhibits colon tumor growth in a mouse model. Asian Pac J Cancer Prev. 2012;13:4037-43 pubmed
    ..It may thus represent a promising approach for the immunotherapy of colorectal cancer. ..
  63. Li C, Wang Y, Wang H, Shi Z, An N, Liu Y, et al. Molecular mechanisms of Lycoris aurea agglutinin-induced apoptosis and G2 /M cell cycle arrest in human lung adenocarcinoma A549 cells, both in vitro and in vivo. Cell Prolif. 2013;46:272-82 pubmed publisher
    ..Lycoris is aurea agglutinin (LAA) has attracted rising attention due to its remarkable bioactivities. Here, we aimed at investigating its anti-tumor activities...
  64. Mi Y, He M, Liu B. [MiR-133b Affect the Proliferation and Drug Sensitivity in A549 Lung Cancer Stem Cells by Targeting PKM2]. Zhongguo Fei Ai Za Zhi. 2017;20:376-381 pubmed publisher
    ..05?????miR-133b???????????????PKM2?????P<0.05??DDP??12 h?miR-133b mimics????????????????P<0.05??miR-133b mimics+DDP?PKM2?????????????miR-133b inhibitor??P<0.05???? ???miR-133b??????PKM2???????????????????????????DDP?????. ..
  65. Yuan S, Wang X, Wei Y. [Anticancer effect of tanshinone and its mechanisms]. Ai Zheng. 2003;22:1363-6 pubmed
  66. Li M, Wang Y, Guo R, Bai Y, Yu Z. Glucocorticoids impair microglia ability to induce T cell proliferation and Th1 polarization. Immunol Lett. 2007;109:129-37 pubmed
    ..Our data suggest that the inhibitory effects of GC on the APC function of microglia may contribute to the stress-induced suppression of T cell response in the CNS. ..
  67. Du X, Lang J, Xu J, Lu Y, Wen Y, Zhao J, et al. Vesicular stomatitis virus matrix protein gene enhances the antitumor effects of radiation via induction of apoptosis. Apoptosis. 2008;13:1205-14 pubmed publisher
    ..This study suggests that Lip-MP enhanced the antitumor activity of radiation by increasing the induction of apoptosis. ..
  68. Duan Z, Zhu X, Zhang Y, Wang Y, Liu Y, Guo H, et al. [Effects of circadian gene mPer1 on therapeutic sensitivity of adriamycin]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2008;39:925-8 pubmed
    ..To study the effects of mPer1 gene on the response of mammary carcinoma EMT6 cells to Adriamycin in vitro...
  69. Zhuang Z, Jian P, Longjiang L, Bo H, Wenlin X. Oral cancer cells with different potential of lymphatic metastasis displayed distinct biologic behaviors and gene expression profiles. J Oral Pathol Med. 2010;39:168-75 pubmed publisher
    ..Additionally, the differentially expressed gene profiles in cancer progression may be helpful in exploring therapeutic targets and provide the foundation for further functional validation of these specific candidate genes for OSCC. ..
  70. Wang Y, Li D, Shi H, Wen Y, Yang L, Xu N, et al. Intratumoral expression of mature human neutrophil peptide-1 mediates antitumor immunity in mice. Clin Cancer Res. 2009;15:6901-11 pubmed publisher
  71. Lu H, Pang W, Hu Y, Yang H, Huang C, Jiang Y. Effects of intracellular zinc depletion on the expression of VDAC in cultured hippocampal neurons. Nutr Neurosci. 2011;14:80-7 pubmed publisher
    ..Present results implicate a possibility that up-regulation of VDAC1 and down-regulation of VDAC2 may participate in hippocampal neuron injury induced by zinc deficiency. ..
  72. Zhang L, Gao X, Men K, Wang B, Zhang S, Qiu J, et al. Gene therapy for C-26 colon cancer using heparin-polyethyleneimine nanoparticle-mediated survivin T34A. Int J Nanomedicine. 2011;6:2419-27 pubmed publisher
    ..This research suggests that HPEI nanoparticle-mediated ms-T34A may have a promising role in C-26 colon carcinoma therapy. ..
  73. Zhao F, Qu Y, Xiong T, Duan Z, Ye Q, Mu D. The neuroprotective role of TERT via an antiapoptotic mechanism in neonatal rats after hypoxia-ischemia brain injury. Neurosci Lett. 2012;515:39-43 pubmed publisher
    ..Our results indicate that TERT might function as an anti-apoptotic protein by inhibiting activation of caspase-3, while further studies are needed to evaluate underlying mechanisms. ..
  74. Chen X, Wu Y, Jiang Y, Zhou Y, Wang Y, Yao Y, et al. Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling. J Mol Med (Berl). 2012;90:1311-9 pubmed publisher
    ..Taken together, our findings suggested that ISL could inhibit the growth of MM via blocking IL-6 signaling and might serve as a promising therapeutic agent for treatment of MM. ..
  75. Du X, He S, Jiang Y, Wei L, Hu W. Adiponectin prevents islet ischemia-reperfusion injury through the COX2-TNFα-NF-κB-dependent signal transduction pathway in mice. J Endocrinol. 2013;218:75-84 pubmed publisher
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