Experts and Doctors on sprague dawley rats in Shanghai, Shanghai Shi, China

Summary

Locale: Shanghai, Shanghai Shi, China
Topic: sprague dawley rats

Top Publications

  1. Guo J, Tu Z. Comet electrophoresis of blood nucleated cells in genotoxicity assessment. Zhongguo Yao Li Xue Bao. 1999;20:975-8 pubmed
    ..Bleomycin and mitomycin C demonstrated a strong dose-dependent DNA damage. Comet assay as a tool to test the genotoxicity of suspected chemicals, is rapid, simple, sensitive, good reproducible, and inexpensive. ..
  2. Hu Z, Liu Q, Shang Q, Zheng M, Yang J, Zhang Y. Identification and characterization of a new member of serpin family- HongrES1 in rat epididymis. Cell Res. 2002;12:407-10 pubmed
    ..Such kind of expression pattern sugested that HongrES1 had potential function in male reproduction. ..
  3. Zhang X, Zhang H, Tu Y, Gao X, Zhou C, Jin M, et al. Identification of a novel protein for memory regulation in the hippocampus. Biochem Biophys Res Commun. 2005;334:418-24 pubmed
    ..Inhibition of HGN by antisense oligonucleotide in area CA1 results in enhanced performance in Morris water maze, as well as elevated long-term potentiation. These results suggest that HGN is involved in negative memory regulation. ..
  4. Hexige S, Guo J, Ma L, Sun Y, Liu X, Ma L, et al. Expression pattern of growth/differentiation factor 3 in human and murine cerebral cortex, hippocampus as well as cerebellum. Neurosci Lett. 2005;389:83-7 pubmed
    ..Present data suggested that GDF3 might play important roles in the central nervous system (CNS), especially in cerebral cortex, hippocampus and cerebellum, and it shed new light on further research of GDF3 in the central nervous system. ..
  5. Wu G, Huang F. Effects of venom defibrase on brain edema after intracerebral hemorrhage in rats. Acta Neurochir Suppl. 2005;95:381-7 pubmed
    ..Defibrase DF-521 batroxobin down-regulate ICAM-1 and complement C3d and C9 expression in the perihematomal area, and attenuate brain edema formation in ICH rats. ..
  6. Yanqing Z, Yu Min L, Jian Q, Bao Guo X, Chuan Zhen L. Fibronectin and neuroprotective effect of granulocyte colony-stimulating factor in focal cerebral ischemia. Brain Res. 2006;1098:161-9 pubmed
  7. Wang Z, Zhang Y, Zhao Z. Inhibition of tetanically sciatic stimulation-induced LTP of spinal neurons and Fos expression by disrupting glutamate transporter GLT-1. Neuropharmacology. 2006;51:764-72 pubmed
    ..In conclusion, glial GLT-1 may play an important role in tetanically sciatic stimulation-induced LTP of spinal nociceptive neurons via the regulation of extracellular levels of glutamate to an appropriate concentration. ..
  8. Ba M, Kong M, Ma G, Yang H, Lu G, Chen S, et al. Cellular and behavioral effects of 5-HT1A receptor agonist 8-OH-DPAT in a rat model of levodopa-induced motor complications. Brain Res. 2007;1127:177-84 pubmed
    ..Moreover, 8-OH-DPAT plus levodopa significantly reduced hyperphosphorylation of GluR1 at serine 845, which was closely associated with levodopa-induced motor complications. ..
  9. Qin Y, Xu G, Wang W. Dendritic abnormalities in retinal ganglion cells of three-month diabetic rats. Curr Eye Res. 2006;31:967-74 pubmed
    ..This plasticity of the surviving RGC dendrites may represent a compensatory response to the overall loss of RGCs in diabetes. ..

More Information

Publications218 found, 100 shown here

  1. Chen Q, He S, Hu X, Yu J, Zhou Y, Zheng J, et al. Differential roles of NR2A- and NR2B-containing NMDA receptors in activity-dependent brain-derived neurotrophic factor gene regulation and limbic epileptogenesis. J Neurosci. 2007;27:542-52 pubmed
    ..The specific requirement of NR2A and its downstream signaling for epileptogenesis implicates attractive new targets for the development of drugs that prevent epilepsy in patients with brain injury. ..
  2. Cai Y, Ma W, Li M, Guo J, Li Y, Wang L, et al. Glutamatergic vestibular neurons express Fos after vestibular stimulation and project to the NTS and the PBN in rats. Neurosci Lett. 2007;417:132-7 pubmed
  3. Guan Q, Zhan Q, He Y, Tan L. Changes in the prodynorphin gene and DARPP-32 state in 6-OHDA-lesioned rats following long-term treatment with l-dopa. Neurosci Lett. 2007;426:64-8 pubmed
    ..Collectively, these findings suggested that changes of the DARPP-32 phosphorylation state may be important for over-activation of the direct pathway. ..
  4. Feng N, Wu P, Li Q, Mei Y, Shi S, Yu J, et al. Oridonin-loaded poly(epsilon-caprolactone)-poly(ethylene oxide)-poly(epsilon-caprolactone) copolymer nanoparticles: preparation, characterization, and antitumor activity on mice with transplanted hepatoma. J Drug Target. 2008;16:479-85 pubmed
    ..Thus, ORI-PCL-PEO-PCL-NPs may be used as a promising delivery system for liver cancer treatment. ..
  5. Li F, Zhang Y, Jing X, Yan C, Shen X. The influence of forepaw palmar sensorimotor deprivation on learning and memory in young rats. Neurosci Res. 2009;63:17-23 pubmed publisher
    ..These findings indicate that palmar surface forepaw sensorimotor deprivation impairs subsequent learning and memory in young rats. Decreased hippocampal pyramidal cell numbers and altered NMDAR1 expression may underlie this impairment. ..
  6. Han P, Shen F, Xie H, Chen Y, Miao C, Mehta J, et al. The combination of atenolol and amlodipine is better than their monotherapy for preventing end-organ damage in different types of hypertension in rats. J Cell Mol Med. 2009;13:726-34 pubmed publisher
    ..The superior effect of the combination was observed in all four models of hypertension...
  7. Cang C, Zhang H, Zhang Y, Zhao Z. PKCepsilon-dependent potentiation of TTX-resistant Nav1.8 current by neurokinin-1 receptor activation in rat dorsal root ganglion neurons. Mol Pain. 2009;5:33 pubmed publisher
    ..These data suggest that activation of NK-1 receptor potentiates Na(v)1.8 sodium current via PKCepsilon-dependent signaling pathway, probably participating in the generation of inflammatory hyperalgesia. ..
  8. Gao S, Zhan Q, Li J, Yang Q, Li X, Chen W, et al. LC-MS/MS method for the simultaneous determination of ethyl gallate and its major metabolite in rat plasma. Biomed Chromatogr. 2010;24:472-8 pubmed publisher
    ..5 and 1.0 ng/mL. The intra-day and inter-day accuracy and precision of the assay were less than 8.0%. This method has been applied successfully to a pharmacokinetic study involving the intragastric administration of ethyl gallate to rats...
  9. Huang R, Ke W, Liu Y, Wu D, Feng L, Jiang C, et al. Gene therapy using lactoferrin-modified nanoparticles in a rotenone-induced chronic Parkinson model. J Neurol Sci. 2010;290:123-30 pubmed publisher
    ..The findings may have implications for long-term non-invasive gene therapy for neurodegenerative diseases in general. ..
  10. Du S, Qiang M, Zeng Z, Ke A, Ji Y, Zhang Z, et al. Inactivation of kupffer cells by gadolinium chloride protects murine liver from radiation-induced apoptosis. Int J Radiat Oncol Biol Phys. 2010;76:1225-34 pubmed publisher
    ..Selective inactivation of Kupffer cells with GdCl3 reduced radiation-induced cytokine production and protected the liver against acute radiation-induced damage. ..
  11. Huang J, Chen Y, Bian W, Yu J, Zhao Y, Liu X. Unilateral amyloid-beta25-35 injection into the rat amygdala increases the expressions of aberrant tau phosphorylation kinases. Chin Med J (Engl). 2010;123:1311-4 pubmed
    ..01). Unilateral injection of Abeta(25-35) into the rat amygdala increases the generation of aberrant phosphorylated tau by increasing GSK-3beta and P(38)MAPK gene expression, that accelerates the process of Alzhemer's disease. ..
  12. Zhao J, Pan H, Li T, Zhang Y, Wei J, Zhao Z. The sensitization of peripheral C-fibers to lysophosphatidic acid in bone cancer pain. Life Sci. 2010;87:120-5 pubmed publisher
    ..LPA and its downstream molecules possibly are promising therapeutic targets for treatment of cancer pain. ..
  13. Sun F, Lin X, Mao L, Ge W, Zhang L, Huang Y, et al. Neuroprotection by melatonin against ischemic neuronal injury associated with modulation of DNA damage and repair in the rat following a transient cerebral ischemia. J Pineal Res. 2002;33:48-56 pubmed
    ..The results suggest that neuroprotection by melatonin against ischemic injury may be related to modulation of apoptosis and DNA repair capacity. ..
  14. Hai J, Li S, Lin Q, Pan Q, Gao F, Ding M. Vascular endothelial growth factor expression and angiogenesis induced by chronic cerebral hypoperfusion in rat brain. Neurosurgery. 2003;53:963-70; discussion 970-2 pubmed
    ..An absence of corresponding astrocytic reactivity during angiogenesis may be an important factor accounting for structural deficits of the blood-brain barrier and the occurrence of normal-perfusion pressure breakthrough. ..
  15. Hou Q, Gao X, Zhang X, Kong L, Wang X, Bian W, et al. SNAP-25 in hippocampal CA1 region is involved in memory consolidation. Eur J Neurosci. 2004;20:1593-603 pubmed
    ..Together, the results suggest that SNAP-25 in the CA1 region is involved in memory consolidation. ..
  16. Tang F, Yue S, Luo Z, Feng D, Wang M, Qian C, et al. Role of N-methyl-D-aspartate receptor in hyperoxia-induced lung injury. Pediatr Pulmonol. 2005;40:437-44 pubmed
    ..We conclude that Glu may play an important role in hyperoxia-induced lung injury by activation of NMDA receptor. ..
  17. Lou L, Shou T, Li Z, Li W, Gu Y. Transhemispheric functional reorganization of the motor cortex induced by the peripheral contralateral nerve transfer to the injured arm. Neuroscience. 2006;138:1225-31 pubmed
    ..Possible mechanisms underlying the alternative changes in cortical functions were discussed in rats and in patients having similar operations. ..
  18. Zhang S, Ge J, Sun A, Xu D, Qian J, Lin J, et al. Comparison of various kinds of bone marrow stem cells for the repair of infarcted myocardium: single clonally purified non-hematopoietic mesenchymal stem cells serve as a superior source. J Cell Biochem. 2006;99:1132-47 pubmed
    ..We conclude that transplantation with single clonally purified MSCs seems to be more beneficial to the cardiac repair than with other stem cells after MI. ..
  19. Li H, Jiang T, Lin Y, Zhao Z, Zhang N. HGF protects rat mesangial cells from high-glucose-mediated oxidative stress. Am J Nephrol. 2006;26:519-30 pubmed
    ..HGF could function as an antioxidant factor and protect against HG-mediated oxidative stress by enhancing ROS scavenging and suppressing ROS production. ..
  20. Wang W, Wang L, Gao L, Wang W. Contribution of AMPA/kainate receptors in the rostral ventrolateral medulla to the hypotensive and sympathoinhibitory effects of clonidine. Am J Physiol Regul Integr Comp Physiol. 2007;293:R1232-8 pubmed
  21. Zhang H, Cang C, Kawasaki Y, Liang L, Zhang Y, Ji R, et al. Neurokinin-1 receptor enhances TRPV1 activity in primary sensory neurons via PKCepsilon: a novel pathway for heat hyperalgesia. J Neurosci. 2007;27:12067-77 pubmed
    ..These results reveal a novel mechanism of NK-1 in primary sensory neurons via a possible autocrine and paracrine action of SP. Activation of NK-1 in these neurons induces heat hyperalgesia via PKCepsilon-mediated potentiation of TRPV1. ..
  22. Cheng Z, Lan D, Wu P, Zhu Y, Dong Y, Ma L, et al. Neurosteroid dehydroepiandrosterone sulphate inhibits persistent sodium currents in rat medial prefrontal cortex via activation of sigma-1 receptors. Exp Neurol. 2008;210:128-36 pubmed
  23. Wan J, Zheng H, Chen Z, Xiao H, Shen Z, Zhou G. Preferential regeneration of photoreceptor from Müller glia after retinal degeneration in adult rat. Vision Res. 2008;48:223-34 pubmed
    ..These results suggest that degeneration may promote preferential differentiation of Müller glia to photoreceptors and provide a potential therapeutic strategy for retinal degenerative diseases. ..
  24. Chen M, Ni Y, Duan H, Qiu Y, Guo C, Jiao Y, et al. Mass spectrometry-based metabolic profiling of rat urine associated with general toxicity induced by the multiglycoside of Tripterygium wilfordii Hook. f. Chem Res Toxicol. 2008;21:288-94 pubmed publisher
  25. Li T, Han D, Chen J, Yu X, Zhang G. Neuroprotection against ischemic brain injury by knockdown of hematopietic progenitor kinase 1 expression. Neuroreport. 2008;19:647-51 pubmed publisher
    ..These results indicate that knockdown of HPK1 expression provides neuroprotection through downregulation activation of the MLK3-MKK7-JNK3 pathway following cerebral ischemia in the rat hippocampus CA1 subfield. ..
  26. Cao L, Zhou B, Yang X. Modulation by BNP of GABA receptors on ON-type rod bipolar cells is dependent on subcellular sites. Brain Res. 2008;1216:46-52 pubmed publisher
    ..All these results suggest that BNP-induced modulation of the activity of GABA receptors may be largely restricted to the inner retina. ..
  27. Liang Q, Zhou Q, Zhang M, Hou W, Cui X, Li C, et al. Prolonged upright posture induces degenerative changes in intervertebral discs in rat lumbar spine. Spine (Phila Pa 1976). 2008;33:2052-8 pubmed publisher
    ..Long-term and repeated assumption of the upright stance accelerates disc degeneration in rats. ..
  28. Tang M, Cui M, Dong Q, Ren H, Xiao B, Luo B, et al. The bradykinin B2 receptor mediates hypoxia/reoxygenation induced neuronal cell apoptosis through the ERK1/2 pathway. Neurosci Lett. 2009;450:40-4 pubmed publisher
    ..These results indicate that B2R plays an important role in protecting neurons from damage induced by H/R and this effect may function through the ERK1/2 pathway. ..
  29. Wu H, Wei L, Bao Y, Lu J, Huang P, Liu Y, et al. Fenofibrate reduces serum retinol-binding protein-4 by suppressing its expression in adipose tissue. Am J Physiol Endocrinol Metab. 2009;296:E628-34 pubmed publisher
  30. Zhou Y, Zheng M, Shi Q, Zhang L, Zhen W, Chen W, et al. An epididymis-specific secretory protein HongrES1 critically regulates sperm capacitation and male fertility. PLoS ONE. 2008;3:e4106 pubmed publisher
    ..These results identify HongrES1 as a novel and critical molecule in the regulation of sperm capacitation and male fertility. ..
  31. Huang Y, Chi F, Han Z, Yang J, Gao W, Li Y. New ectopic vestibular hair cell-like cells induced by Math1 gene transfer in postnatal rats. Brain Res. 2009;1276:31-8 pubmed publisher
    ..Our study might pave the way for further in vivo studies on vestibular Math1 adenoviral vector gene transfer. ..
  32. Liu F, Zheng X, Li B. The anterior cingulate cortex is involved in retrieval of long-term/long-lasting but not short-term memory for step-through inhibitory avoidance in rats. Neurosci Lett. 2009;460:175-9 pubmed publisher
    ..Thus, the ACC is required for the retrieval of long-term/long-lasting IA memory, but is dispensable for short-term one. ..
  33. Dou F, Huang L, Yu P, Zhu H, Wang X, Zou J, et al. Temporospatial expression and cellular localization of oligodendrocyte myelin glycoprotein (OMgp) after traumatic spinal cord injury in adult rats. J Neurotrauma. 2009;26:2299-311 pubmed publisher
    ..Thus, our study has provided evidence for temporospatial expression and cellular localization of OMgp following SCI and suggested that this molecule may contribute to the overall inhibition of axonal regeneration. ..
  34. Zhou H, Chen W, Zhu D, Wu L, Zhang J, Han W, et al. The PDE1A-PKCalpha signaling pathway is involved in the upregulation of alpha-smooth muscle actin by TGF-beta1 in adventitial fibroblasts. J Vasc Res. 2010;47:9-15 pubmed publisher
    ..Our study thus unveils a novel signaling mechanism underlying TGF-beta(1)-induced adventitial myofibroblast formation. ..
  35. Zhang L, Liu Q, Zhou Y, Zhang Y. Baculo-expression and enzymatic characterization of CES7 esterase. Acta Biochim Biophys Sin (Shanghai). 2009;41:731-6 pubmed
    ..The recombinant protein had carboxylesterase activity hydrolyzing cholesterol ester and choline ester. CES7 as carboxylesterase might be involved in ester hydrolysis, sperm maturation, and storage in male reproductive tract. ..
  36. Liang Y, Huang L, Yang J. Differential expression of ryanodine receptor in the developing rat cochlea. Eur J Histochem. 2009;53:249-60 pubmed
    ..Morphological and Ca imaging results suggested that RyRs expression is related to cochlear maturity, and may play an important role in its function. ..
  37. He M, Zhang Z, Guan C, Xia D, Yuan X. Leading tip drives soma translocation via forward F-actin flow during neuronal migration. J Neurosci. 2010;30:10885-98 pubmed publisher
    ..Thus, the tip of the leading process actively pulls the soma forward during neuronal migration through a myosin II-dependent forward F-actin flow along the leading process. ..
  38. Wu Z, Qiu L. Effect of nitric oxide on iron-mediated cytotoxicity in primary cultured renal proximal tubules. Cell Biochem Funct. 2001;19:237-47 pubmed
    ..The hydroxyl group is the major mediator in our model and the pro-oxidant role of NO is probably due to its ability to promote the Fenton reaction and form both ONOO(-) and *OH via its interaction with ROS. ..
  39. Yang J, Yin M. [Effect of 5 polycyclic aromatic hydrocarbons on estrogen receptor binding in rats]. Wei Sheng Yan Jiu. 2002;31:154-6 pubmed
    ..05). The results from this study indicate that penzo(a)pyrene, 7,12-dimethyl benz(a) anthracene and pentacene have significant estrogenic activity. ..
  40. Chen Y, Shen Z, Chen W. [Molecular mechanism of epimedium flavonoids in immune homeostasis remodeling in aged rats revealed by lymphocyte gene expression profile]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004;24:59-62 pubmed
    ..To elucidate the gene regulatory pattern of Epimedium flavonoids (EF) in immune homeostasis remodeling in the aged rats...
  41. Zhou Z, Xu C, Guo Q, Hu Y, Zhang Y, Wang Y. Spatial and temporal expression of germ cell nuclear factor in murine epididymis. Asian J Androl. 2004;6:23-8 pubmed
    ..GCNF could be found in the nuclei of the principal, apical, narrow, clear and halo cells. GCNF may play an important role in epididymal differentiation and development and in sperm maturation. ..
  42. Zhang J, Zhang X, Gao J, Shen P, Ma E, Gu H, et al. [Impact of antipyretic and purgative herbs on intestinal mucosal barrier and inflammatory response in treatment of acute cholangitis in rats]. Zhong Xi Yi Jie He Xue Bao. 2005;3:211-5 pubmed
  43. Li T, Fan Y, Luo Y, Xiao B, Lu C. In vivo delivery of a XIAP (BIR3-RING) fusion protein containing the protein transduction domain protects against neuronal death induced by seizures. Exp Neurol. 2006;197:301-8 pubmed
    ..The significance of these findings in the treatment of epilepsy still needs to be extensively studied. ..
  44. Yu X, Wu D, Yuan J, Zhang R, Hu Z. Gastroprotective effect of fructus evodiae water extract on ethanol-induced gastric lesions in rats. Am J Chin Med. 2006;34:1027-35 pubmed
    ..These results suggested that FE prevented ethanol-induced gastric mucosal lesions by strengthening the mucosal barrier integrity and increasing gastric mucosal nitric oxide (NO) synthesis. ..
  45. Jin Y, Zhong Y, Yang X. Natriuretic peptides are localized to rat retinal amacrine cells. Neurosci Lett. 2007;421:106-9 pubmed
    ..Together with a previous immunocytochemical study, showing that NPR-B is present in cultured rat GABAergic ACs, our results further suggest that NPs produced in ACs may also modulate their own activity. ..
  46. Yao J, Sun X, Wang Y, Xu G, Qian J. Math5 promotes retinal ganglion cell expression patterns in retinal progenitor cells. Mol Vis. 2007;13:1066-72 pubmed
    ..001). Transfection by pIRES2-EGFP-Math5 could change the expression of Delta-1, Hes1, and Brn-3b. Math5 may up-regulate RGC expression patterns in RPCs and change the expression of Math5-associated genes. ..
  47. Lu J, Li G, Lan M, Zhang S, Fan W, Wang H, et al. Pax4 paired domain mediates direct protein transduction into mammalian cells. Endocrinology. 2007;148:5558-65 pubmed
    ..These data suggest that Pax4 protein transduction could be a safe and valuable strategy for protecting islet cell growth in culture from apoptosis and promoting islet cell differentiation. ..
  48. Li T, Qiu Y, Mao J, Yang P, Rui Y, Chen W. Protective effects of Guizhi-Fuling-Capsules on rat brain ischemia/reperfusion injury. J Pharmacol Sci. 2007;105:34-40 pubmed
    ..These results suggested that GZFLC may be beneficial for the treatment of brain ischemia-reperfusion injury partly due to its anti-inflammatory properties. ..
  49. Jia Y, Wei W, Ma B, Xu Y, Liu W, Wang Y, et al. Activation of p38 MAPK by reactive oxygen species is essential in a rat model of stress-induced gastric mucosal injury. J Immunol. 2007;179:7808-19 pubmed
    ..Our findings suggested that inhibition of p38 activation might be a potential strategy for the prophylaxis and treatment of stress ulceration. ..
  50. Wu X, Zhou Q, Huang L, Sun A, Wang K, Zou Y, et al. Ageing-exaggerated proliferation of vascular smooth muscle cells is related to attenuation of Jagged1 expression in endothelial cells. Cardiovasc Res. 2008;77:800-8 pubmed
    ..Ageing enhanced VSMC proliferation, at least in part, through impairing Jagged1 expression in the EC after vascular injury. ..
  51. Zhang P, Liu Y, Feng N, Xu J. Preparation and evaluation of self-microemulsifying drug delivery system of oridonin. Int J Pharm. 2008;355:269-76 pubmed publisher
    ..The absorption of oridonin from SMEDDS showed a 2.2-fold increase in relative bioavailability compared with that of the suspension. Our studies demonstrated the promising use of SMEDDS for the delivery of oridonin by the oral route. ..
  52. Xie H, Dong Z, Ma F, Bauer W, Wang X, Wu G. Involvement of serotonin 2A receptors in the analgesic effect of tramadol in mono-arthritic rats. Brain Res. 2008;1210:76-83 pubmed publisher
    ..The increase in this receptor mRNA in the chronic study may contribute to the sustaining effect of tramadol long-term treatments in clinical practice. ..
  53. Yao Y, Wu W, Liu A, Deng S, Bi K, Liu X, et al. Interaction of salvianolic acids and notoginsengnosides in inhibition of ADP-induced platelet aggregation. Am J Chin Med. 2008;36:313-28 pubmed
    ..The influence of combination on the absorption and/or metabolism of SA may be one of the reasons for the synergism of SA and NG in vivo. ..
  54. Wang H, Wang Y, Liang Y, Liu Y, Peng W. [Wenyang Huoxue Recipe up-regulates the expression of angiopoietin-1 mRNA in rats with chronic aristolochic acid nephropathy]. Zhong Xi Yi Jie He Xue Bao. 2008;6:508-11 pubmed publisher
    ..Renal pathology showed that renal damage in WYHXR-treated group was significantly reduced as compared with the CAM group. WYHXR can up-regulate the expression of Ang-l mRNA, which may be its action mechanism in protecting the kidneys. ..
  55. Zhou X, Wu K, Liang B, Fu X, Luo Z. TrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesis. Proc Natl Acad Sci U S A. 2008;105:17181-6 pubmed publisher
    ..Thus depolarization- or BDNF-dependent dendrite development may be mediated by GGT-induced prenylation of Rho GTPases. ..
  56. Zhang Y, Wang Y, Zhang Q, Liu X, Liu X, Jiao L, et al. Interaction of Mint2 with TrkA is involved in regulation of nerve growth factor-induced neurite outgrowth. J Biol Chem. 2009;284:12469-79 pubmed publisher
    ..Taken together, our data provide evidence that Mint2 is a novel TrkA-regulating protein that affects NGF-induced neurite outgrowth, possibly through a mechanism involving retention of TrkA in the Golgi apparatus. ..
  57. Kong M, Ba M, Song L, Liu Z. Comparative effects of acute or chronic administration of levodopa to 6-OHDA-lesioned rats on the expression and phosphorylation of N-methyl-D-aspartate receptor NR1 subunits in the striatum. Neurochem Res. 2009;34:1513-21 pubmed publisher
    ..Activated NMDA receptor NR1-mediated mechanisms are involved in the persistent expression of the motor response alterations that appear during chronic levodopa therapy of parkinsonian rats and continue after treatment withdrawal. ..
  58. Chen Y, Ma Y, Ma W. Pharmacokinetics and bioavailability of cinnamic acid after oral administration of Ramulus Cinnamomi in rats. Eur J Drug Metab Pharmacokinet. 2009;34:51-6 pubmed
    ..The results showed that plasma CA in RC group might partly come from transformation of CNMA in RC. ..
  59. Zhang S, Xu M, Miao Q, Poo M, Zhang X. Endocannabinoid-dependent homeostatic regulation of inhibitory synapses by miniature excitatory synaptic activities. J Neurosci. 2009;29:13222-31 pubmed publisher
    ..Thus, mEPSCs contribute to the maintenance of inhibitory synaptic function and the absence of mEPSCs results in presynaptic suppression of inhibitory synapses via protein synthesis-dependent elevation of eCB signaling. ..
  60. Xiong A, Yang L, He Y, Zhang F, Wang J, Han H, et al. Identification of metabolites of adonifoline, a hepatotoxic pyrrolizidine alkaloid, by liquid chromatography/tandem and high-resolution mass spectrometry. Rapid Commun Mass Spectrom. 2009;23:3907-16 pubmed publisher
    ..These metabolites are all involved in both phase I and phase II metabolic processes and the principal in vivo metabolism pathways of adonifoline were proposed. ..
  61. Sui L, Ren W, Li B. Administration of thyroid hormone increases reelin and brain-derived neurotrophic factor expression in rat hippocampus in vivo. Brain Res. 2010;1313:9-24 pubmed publisher
    ..These findings suggest that association of transcriptional coactivators and RNA Pol II with gene promoters may be a possible mechanism explaining T3-induced reelin and BDNF expression in the hippocampus of young adult rats. ..
  62. Cheng L, Lu N, Zhang Y, Zhao Z. Ryanodine receptors contribute to the induction of nociceptive input-evoked long-term potentiation in the rat spinal cord slice. Mol Pain. 2010;6:1 pubmed publisher
    ..These data indicate that activation of presynaptic RyRs play a crucial role in the induction of LTP in the spinal pain pathway, probably through enhancement of transmitter release. ..
  63. Ji L, Liu T, Wang Z. Pyrrolizidine alkaloid clivorine induced oxidative injury on primary cultured rat hepatocytes. Hum Exp Toxicol. 2010;29:303-9 pubmed publisher
    ..Taken together, our results demonstrated that clivorine induced toxicity on primary cultured rat hepatocytes by causing the damage on cellular redox balance. ..
  64. Wu F, Bian J, Miao X, Huang S, Xu X, Gong D, et al. Intrathecal siRNA against Toll-like receptor 4 reduces nociception in a rat model of neuropathic pain. Int J Med Sci. 2010;7:251-9 pubmed
    ..g., TNF-alpha and IL-1 beta). These findings suggest that suppression of TLR4 mediated by intrathecally administered siRNA may be a new strategy for the treatment of neuropathic pain. ..
  65. Zhang R, Lu C, Ren H, Xiao B. Metabolic changes of arachidonic acid after cerebral ischemia-reperfusion in diabetic rats. Exp Neurol. 2003;184:746-52 pubmed
    ..A reduction of arachidonic acid metabolites mediated by inhibitors of its metabolites could be helpful in preventing ischemic brain injury in diabetic rats. ..
  66. Wang Z, Li G, Tang W, Yin M. Neuroprotective effects of stearic acid against toxicity of oxygen/glucose deprivation or glutamate on rat cortical or hippocampal slices. Acta Pharmacol Sin. 2006;27:145-50 pubmed
    ..Stearic acid can protect brain slices (cortical or hippocampal) against injury induced by OGD or glutamate. Its neuroprotective effect may be mainly mediated by the activation of PPAR-gamma. ..
  67. Shan L, Liu R, Shen Y, Zhang W, Zhang C, Wu D, et al. Gastroprotective effect of a traditional Chinese herbal drug "Baishouwu" on experimental gastric lesions in rats. J Ethnopharmacol. 2006;107:389-94 pubmed
    ..This study demonstrates the gastroprotective property of Baishouwu for the first time. ..
  68. Fan H, Fan F, Bao L, Pei G. SNAP-25/syntaxin 1A complex functionally modulates neurotransmitter gamma-aminobutyric acid reuptake. J Biol Chem. 2006;281:28174-84 pubmed
    ..Thus our findings delineate a further molecular mechanism for the regulation of GABA reuptake by a target SNARE complex and suggest a direct coordination between GABA release and reuptake. ..
  69. Zhang Y, Cai G, Ni X, Sun J. The role of ERK activation in the neuronal excitability in the chronically compressed dorsal root ganglia. Neurosci Lett. 2007;419:153-7 pubmed
    ..Taken together, the excitation of CCD neurons might be attributed to the CCD-induced activation of ERK, which suppressed the A-type fast inactivating potassium conductance in CCD neurons. ..
  70. Yu Z, Wang D, Lin S. [Effects of TX0201 abstracted from heart-regulating formula on spatial learning and regulation of Bax mRNA, Bcl-2 mRNA level in brain of rat with Alzheimer's disease]. Zhongguo Zhong Yao Za Zhi. 2007;32:839-42 pubmed
    ..TX0201 could ameliorate the learning and memory ability of these model rats by alleviating neuron apoptosis by means of regulating the abnormal expression of Bax mRNA in brain. ..
  71. Su D, Wang Z, Zheng Y, Zhao Y, Wang X. Dose-dependent neuroprotection of delta opioid peptide [D-Ala2, D-Leu5] enkephalin in neuronal death and retarded behavior induced by forebrain ischemia in rats. Neurosci Lett. 2007;423:113-7 pubmed
  72. Lin Y, Zhang N, Guo H, Kong D, Jiang T, Liang W, et al. Recombinant tissue factor pathway inhibitor induces apoptosis in cultured rat mesangial cells via its Kunitz-3 domain and C-terminal through inhibiting PI3-kinase/Akt pathway. Apoptosis. 2007;12:2163-73 pubmed
    ..Our findings suggest that rTFPI has the potential usefulness in inducing apoptosis of MsCs under inflammatory conditions. ..
  73. Zhao M, Chen J, Wang W, Wang L, Ma L, Shen H, et al. Psychological stress induces hypoferremia through the IL-6-hepcidin axis in rats. Biochem Biophys Res Commun. 2008;373:90-3 pubmed publisher
    ..These changes were blocked by the injection of IL-6 monoclonal antibody. In conclusion, the IL-6-hepcidin axis is up-regulated by psychological stress in rats, resulting in hypoferremia and increase of hepatic iron storage. ..
  74. Zhang M, Zhou Q, Liang Q, Li C, Holz J, Tang D, et al. IGF-1 regulation of type II collagen and MMP-13 expression in rat endplate chondrocytes via distinct signaling pathways. Osteoarthritis Cartilage. 2009;17:100-6 pubmed publisher
    ..In rat endplate chondrocytes the PI3K pathway mainly transduces IGF-1 effect on col2 expression while the ERK pathway mediates IGF-1 effect on MMP-13 expression. ..
  75. Xiao L, Chen Y. Culture condition and embryonic stage dependent silence of glucocorticoid receptor expression in hippocampal neurons. J Steroid Biochem Mol Biol. 2008;111:147-55 pubmed publisher
  76. Sheng H, Sun T, Cong B, He P, Zhang Y, Yan J, et al. Corticotropin-releasing hormone stimulates SGK-1 kinase expression in cultured hippocampal neurons via CRH-R1. Am J Physiol Endocrinol Metab. 2008;295:E938-46 pubmed publisher
    ..Our results suggest that CRH act on CRH-R1 to stimulate SGK-1 mRNA and protein expression in cultured hippocampal neurons via a mechanism that is involved in AC/PKA signaling pathways. ..
  77. Zhang F, Feng Y, Zhou R, Zhang Y, Chen B. [Observation on the central afferent pathway of "Guanyuan" (CV 4) under normal and pathological states and the influence of electroacupuncture]. Zhen Ci Yan Jiu. 2008;33:147-53 pubmed
    ..05). Following OVX, PRV-IR positive cells in neuroendocrine-related nuclei of hypothalamus reduced significantly in number; EA of "Guanyuan" (CV 4) can promote the recovery of these neurons in above mentioned nuclei. ..
  78. Wang L, Hu B, Wong W, Lu P, Wu W, Xu X. Glial and axonal responses in areas of Wallerian degeneration of the corticospinal and dorsal ascending tracts after spinal cord dorsal funiculotomy. Neuropathology. 2009;29:230-41 pubmed publisher
    ..Information obtained in this study should be useful for designing experiments aimed at modifying this region to accommodate endogenous or exogenous repair following SCI...
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    ..Our results suggested that DIDS is beneficial in rat model of gastric injury through mechanisms that involve inhibiting inflammatory cell infiltration and lipid peroxidation and up-regulating the COX-2/PGE2 pathway. ..
  81. Xu J, Yan H, Yang B, Tong L, Zou Y, Tian Y. Effects of lead exposure on hippocampal metabotropic glutamate receptor subtype 3 and 7 in developmental rats. J Negat Results Biomed. 2009;8:5 pubmed publisher
  82. Liu H, Li S, Zhang Y, Yan Y, Li Y. Dynamic regulation of glutamic acid decarboxylase 65 gene expression in rat testis. Acta Biochim Biophys Sin (Shanghai). 2009;41:545-53 pubmed
    ..The above results suggested that GAD65 gene expression is dynamically regulated at multiple levels during post-natal testis maturation. ..
  83. Guo C, Pan Q, Cheng T, Jiang B, Chen G, Li D. Changes in microRNAs associated with hepatic stellate cell activation status identify signaling pathways. FEBS J. 2009;276:5163-76 pubmed publisher
    ..These findings provide in vitro and in vivo evidence that the mitochondrial pathway of apoptosis plays a significant role in the progression of liver fibrogenesis via HSC activation. ..
  84. Feng D, Chen E, Li X, Liu Y, Wang Y. Standardizing optic nerve crushes with an aneurysm clip. Neurol Res. 2010;32:476-81 pubmed publisher
    ..The present findings suggest that Yasargil aneurysm clip effectively produces permanent injury to the optic nerve with evidence from retrograde tracing of RGCs and may provide a standard technique for optic nerve crush studies. ..
  85. Liu X, Pan L, Chen P, Zhu Y. Leonurine improves ischemia-induced myocardial injury through antioxidative activity. Phytomedicine. 2010;17:753-9 pubmed publisher
    ..Taken together, our results demonstrated that leonurine attenuated myocardium injury during MI via antioxidative and anti-apoptotic effects and leonurine might become a useful adjuvant cardioprotective agent. ..
  86. Xu B, Zhang W, Yang J, Xu H, Deng X, Zhang Y. Dexmedetomidine blocks thermal hyperalgesia and spinal glial activation in rat model of monoarthritis. Acta Pharmacol Sin. 2010;31:523-30 pubmed publisher
    ..Systemic dexmedetomidine inhibits the activation of spinal glia, which is possibly associated with its antihyperalgesia in monoarthritic rats. ..
  87. Liu G, Li Y, Sun J, Cui L, Zhang W, Cao Y. [Repair of calvarial defects with human umbilical cord blood derived mesenchymal stem cells and demineralized bone matrix in athymic rats]. Zhonghua Zheng Xing Wai Ke Za Zhi. 2010;26:34-8 pubmed
    ..Tissue-engineered bone composed of osteogenically-induced human UCB-MSCs on DBM scaffolds could successfully repair the critical-sized calvarial defects in athymic rat models. ..
  88. Tan Z, Peng Y, Song H, Zheng J, Yu X. N-cadherin-dependent neuron-neuron interaction is required for the maintenance of activity-induced dendrite growth. Proc Natl Acad Sci U S A. 2010;107:9873-8 pubmed publisher
    ..In summary, these results identify a previously unexplored and specific function for activity-induced, N-cadherin-mediated neuron-neuron contacts in the maintenance of dendrite arbors. ..
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    ..Treadmill pre-training has a significant neuroprotective function against ischemia/reperfusion injury, by suppressing glutamate release resulting from cerebral ischemia, and this effect may be mediated by downregulation of mGluR1. ..
  90. Li Q, Song X, Zou J, Wang G, Kremneva E, Li X, et al. Attenuation of microRNA-1 derepresses the cytoskeleton regulatory protein twinfilin-1 to provoke cardiac hypertrophy. J Cell Sci. 2010;123:2444-52 pubmed publisher
  91. Yu L, Zhang Z, Zhang H, Ding J. Biodegradability and biocompatibility of thermoreversible hydrogels formed from mixing a sol and a precipitate of block copolymers in water. Biomacromolecules. 2010;11:2169-78 pubmed publisher
    ..As such, the thermosensitive hydrogel of copolymer mixture is confirmed to be a promising candidate of an injectable biomaterial for drug delivery and tissue engineering. ..
  92. Zhang F, Wu Y, Jia J, Hu Y. Pre-ischemic treadmill training induces tolerance to brain ischemia: involvement of glutamate and ERK1/2. Molecules. 2010;15:5246-57 pubmed publisher
    ..This study suggests that pre-ischemic treadmill training might induce neuroprotection by inhibiting the phospho-ERK1/2 over-activation and reducing excessive glutamate release. ..